Ubiquitinligaser vid cancer — mekanismer, resistens och målstyrd proteindegradation – Olle Sangfelts forskargrupp

Publikationer

Utvalda publikationer

• Article: MOLECULAR CELL. 2023;83(20):3720-3739.e8

  FBXL12 degrades FANCD2 to regulate replication recovery and promote cancer cell survival under conditions of replication stress

  Brunner A; Li Q; Fisicaro S; Kourtesakis A; Viiliainen J; Johansson HJ; Pandey V; Mayank AK; Lehtio J; Wohlschlegel JA; Spruck C; Rantala JK; Orre LM; Sangfelt O
• Preprint: BIORXIV. 2023

  Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia

  Malyukova A; Lahnalampi M; Falqués-Costa T; Pölönen P; Sipola M; Mehtonen J; Teppo S; Viiliainen J; Lohi O; Hagström-Andersson AK; Heinäniemi M; Sangfelt O
• Article: ONCOGENE. 2021;40(13):2367-2381

  A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma

  Cheung BB; Kleynhans A; Mittra R; Kim PY; Holien JK; Nagy Z; Ciampa OC; Seneviratne JA; Mayoh C; Raipuria M; Gadde S; Massudi H; Wong IPL; Tan O; Gong A; Suryano A; Diakiw SM; Liu B; Arndt GM; Liu T; Kumar N; Sangfelt O; Zhu S; Norris MD; Haber M; Carter DR; Parker MW; Marshall GM
• Article: CELL. 2021;184(2):352-369.e23

  FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

  Shen JZ; Qiu Z; Wu Q; Finlay D; Garcia G; Sun D; Rantala J; Barshop W; Hope JL; Gimple RC; Sangfelt O; Bradley LM; Wohlschlegel J; Rich JN; Spruck C
• Article: SCIENTIFIC REPORTS. 2020;10(1):22334

  K63-linked ubiquitylation induces global sequestration of mitochondria

  Richard TJC; Herzog LK; Vornberger J; Rahmanto AS; Sangfelt O; Salomons FA; Dantuma NP
• Article: GENOME MEDICINE. 2020;12(1):99

  Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities

  Mehtonen J; Teppo S; Lahnalampi M; Kokko A; Kaukonen R; Oksa L; Bouvy-Liivrand M; Malyukova A; Makinen A; Laukkanen S; Makinen PI; Rounioja S; Ruusuvuori P; Sangfelt O; Lund R; Lonnberg T; Lohi O; Heinaniemi M
• Article: NEOPLASIA. 2020;22(9):390-398

  Ex vivo assessment of targeted therapies in a rare metastatic epithelial-myoepithelial carcinoma

  Makela R; Arjonen A; Rahmanto AS; Harma V; Lehtio J; Kuopio T; Helleday T; Sangfelt O; Kononen J; Rantala JK
• Article: ELIFE. 2020;9:e57894

  PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

  Brunner A; Rahmanto AS; Johansson H; Franco M; Viiliainen J; Gazi M; Frings O; Fredlund E; Spruck C; Lehtio J; Rantala JK; Larsson L-G; Sangfelt O
• Article: EMBO JOURNAL. 2016;35(20):2192-2212

  FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

  Rahmanto AS; Savov V; Brunner A; Bolin S; Weishaupt H; Malyukova A; Rosen G; Cancer M; Hutter S; Sundstrom A; Kawauchi D; Jones DTW; Spruck C; Taylor MD; Cho Y-J; Pfister SM; Kool M; Korshunov A; Swartling FJ; Sangfelt O
• Article: EMBO MOLECULAR MEDICINE. 2013;5(7):1067-1086

  CDK-mediated activation of the SCF^FBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer

  Cepeda D; Ng H-F; Sharifi HR; Mahmoudi S; Soto Cerrato V; Fredlund E; Magnusson K; Nilsson H; Malyukova A; Rantala J; Klevebring D; Vinals F; Bhaskaran N; Zakaria SM; Rahmanto AS; Grotegut S; Nielsen ML; Szigyarto CA-K; Sun D; Lerner M; Navani S; Widschwendter M; Uhlen M; Jirstrom K; Ponten F; Wohlschlegel J; Grander D; Spruck C; Larsson L-G; Sangfelt O
• Article: NATURE COMMUNICATIONS. 2012;3:976

  Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

  Arabi A; Ullah K; Branca RMM; Johansson J; Bandarra D; Haneklaus M; Fu J; Aries I; Nilsson P; Den Boer ML; Pokrovskaja K; Grander D; Xiao G; Rocha S; Lehtio J; Sangfelt O
• Article: CANCER RESEARCH. 2007;67(12):5611-5616

  The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling

  Malyukova A; Dohda T; von der Lehr N; Akhondi S; Corcoran M; Heyman M; Spruck C; Grander D; Lendahl U; Sangfelt O
• Article: NATURE. 2001;413(6853):316-322

  Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

  Strohmaier H; Spruck CH; Kaiser P; Won KA; Sangfelt O; Reed SI

Medarbetare och kontakt

Gruppledare

• 

  Olov Sangfelt

  Senior Forskare | Docent

  Telefon +46852486395

  E-postadress olle.sangfelt@ki.se

Alla medarbetare i gruppen

• Andrä Walter Brunner

  Forskningsspecialist

  E-postadress andra.brunner@ki.se
• Jinjiang Chou

  Postdoktor

  E-postadress jinjiang.chou@ki.se
• Aljona Maljukova

  Anknuten till Forskning

  E-postadress aljona.maljukova@ki.se