Cancerns cellbiologi – Staffan Strömblads forskargrupp

Gruppen undersöker hur ECM:s mekaniska egenskaper påverkar olika cellulära funktioner under cancerutveckling och progression.

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Institutionen för medicin, Huddinge

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Publikationer

Utvalda publikationer

Article: CELL COMMUNICATION AND SIGNALING. 2025;23(1):269
Matrix stiffness-induced IKBKE and MAPK8 signaling drives a phenotypic switch from DCIS to invasive breast cancer
Yan F; Goransson S; Olofsson H; Vogiatzakis C; Acharekar A; Stromblad S
Article: MOLECULAR SYSTEMS BIOLOGY. 2023;19(6):e11490
Multisite assessment of reproducibility in high-content cell migration imaging data
Hu J; Serra-Picamal X; Bakker G-J; Van Troys M; Winograd-Katz S; Ege N; Gong X; Didan Y; Grosheva I; Polansky O; Bakkali K; Van Hamme E; van Erp M; Vullings M; Weiss F; Clucas J; Dowbaj AM; Sahai E; Ampe C; Geiger B; Friedl P; Bottai M; Stromblad S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2023;654:73-79
An extracellular matrix stiffness-induced breast cancer cell transcriptome resembles the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC)
Goransson S; Chen S; Olofsson H; Larsson O; Stromblad S
Article: SCIENCE ADVANCES. 2022;8(12):eabl3667
Local temporal Rac1-GTP nadirs and peaks restrict cell protrusions and retractions
Hu J; Gong X; Stromblad S
Article: MOLECULAR & CELLULAR ONCOLOGY. 2020;7(2):1684129
New control of the senescence barrier in breast cancer
Costa TDF; Stromblad S
Article: SCIENTIFIC REPORTS. 2019;9(1):14436
Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion
Rabieifar P; Zhuang T; Costa TDF; Zhao M; Stromblad S
Article: NATURE COMMUNICATIONS. 2019;10(1):3589
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Costa TDF; Zhuang T; Lorent J; Turco E; Olofsson H; Masia-Balague M; Zhao M; Rabieifar P; Robertson N; Kuiper R; Sjolund J; Spiess M; Hernandez-Varas P; Rabenhorst U; Roswall P; Ma R; Gong X; Hartman J; Pietras K; Adams PD; Defilippi P; Stromblad S
Article: JOURNAL OF CELL BIOLOGY. 2019;218(7):2086-2095
Clathrin-containing adhesion complexes
Lock JG; Baschieri F; Jones MC; Humphries JD; Montagnac G; Stromblad S; Humphries MJ
Article: NATURE CELL BIOLOGY. 2018;20(11):1290-1302
Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis.
Lock JG; Jones MC; Askari JA; Gong X; Oddone A; Olofsson H; Göransson S; Lakadamyali M; Humphries MJ; Strömblad S
Article: EMBO JOURNAL. 2018;37(17):e98994
KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration
Gong X; Didan Y; Lock JG; Stromblad S
Article: JOURNAL OF CELL BIOLOGY. 2018;217(6):1929-1940
Active and inactive β1 integrins segregate into distinct nanoclusters in focal adhesions
Spiess M; Hernandez-Varas P; Oddone A; Olofsson H; Blom H; Waithe D; Lock JG; Lakadamyali M; Stromblad S
Article: JOURNAL OF IMMUNOLOGY. 2018;200(5):1790-1801
Inflammation-Sensitive Myosin-X Functionally Supports Leukocyte Extravasation by Cdc42-Mediated ICAM-1-Rich Endothelial Filopodia Formation
Kroon J; Schaefer A; van Rijssel J; Hoogenboezem M; van Alphen F; Hordijk P; Stroes ESG; Stromblad S; van Rheenen J; van Buul JD
Article: METHODS IN MOLECULAR BIOLOGY. 2018;1749:119-134
Using Systems Microscopy to Understand the Emergence of Cell Migration from Cell Organization.
Strömblad S; Lock JG
Article: ONCOTARGET. 2017;8(44):77061-77074
Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization
Zhao M; Spiess M; Johansson HJ; Olofsson H; Hu J; Lehtio J; Stromblad S
Article: SCIENTIFIC REPORTS. 2017;7(1):7031
Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development
Zhao M; Rabieifar P; Costa TDF; Zhuang T; Minden A; Lohr M; Heuchel R; Stromblad S
Article: ONCOGENE. 2016;35(15):1955-1964
RING finger protein 31 promotes p53 degradation in breast cancer cells
Zhu J; Zhao C; Zhuang T; Jonsson P; Sinha I; Williams C; Stromblad S; Dahlman-Wright K
Article: ELIFE. 2016;5:e11384
An analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modes
Shafqat-Abbasi H; Kowalewski JM; Kiss A; Gong X; Hernandez-Varas P; Berge U; Jafari-Mamaghani M; Lock JG; Stromblad S
Article: PLOS ONE. 2015;10(8):e0135204
Disentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions
Kowalewski JM; Shafqat-Abbasi H; Jafari-Mamaghani M; Ganebo BE; Gong X; Stromblad S; Lock JG
Article: NATURE COMMUNICATIONS. 2015;6:7524
A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime
Hernandez-Varas P; Berge U; Lock JG; Stromblad S
Review: EXPERIMENTAL CELL RESEARCH. 2013;319(11):1663-1670
Cell to extracellular matrix interactions and their reciprocal nature in cancer
van Dijk M; Goransson SA; Stromblad S
Review: SEMINARS IN CANCER BIOLOGY. 2008;18(1):65-76
Cell-matrix adhesion complexes:: Master control machinery of cell migration
Lock JG; Wehrle-Haller B; Stroemblad S
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(13):4587-4597
Cell attachment to the extracellular matrix induces proteasomal degradation of p21^CIP1 via Cdc42/Rac1 signaling
Bao WJ; Thullberg M; Zhang HQ; Onischenko A; Strömblad S
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Finansiering

Forskningsbidrag

Cell-matrixinteraktioner i cancer
Vetenskapsrådet
1 January 2026 - 1 January 2029
Vilka pre-invasiva tumörer ska behandlas eller följas upp?
Radiumhemmets forskningsfonder
1 January 2025 - 1 January 2027
Cell-matrixinteraktioner i cancer
Cancerfonden
1 January 2024 - 1 January 2026
SWEEPICS: SWEPT LASERS FOR NON-INVASIVE DIAGNOSTICS
European Commission
1 December 2023 - 31 August 2027
Swept lasers have enabled paradigm-shifts in biomedical imaging and diagnostics. The SWEEPICS project will research and develop the next generation of swept source lasers with flexible pulse modulation capability, high power output, multi-wavelength coherent output and multi-application potential. SWEEPICS will develop new laser-based systems: a high-speed, high resolution multiphoton high content screening system, a multimodal non-invasive imaging system based on high-speed photoacoustics and multiphoton microscopy, and a smart microscope for accelerated acquisition&diagnostics. The inter-disciplinary consortium of European partners will showcase the SWEEPICS technology in cutting-edge use cases based on novel vascular organoids for animal-free drug-testing and infection studies. This disruptive SWEEPICS technology will rapidly generate high-resolution diagnostic imaging in three-dimension, where the high imaging depth permits penetrating millimeter deep into tissue-like organoids and imaging at high temporal and spatial resolution in order to allow for a drastic reduction of animal testing and increased speed of diagnostic results. It will allow the study of dynamic processes in real-time and at multiple length scales, enabling researchers to observe how cells and tissues respond to viral infections or pathogen-induced inflammation, while also permitting a high-throughput enabled discovery of novel diagnostic biomarkers. Overall, this technology represents a major breakthrough in capable laser technology for high accuracy and throughput medical diagnostics and is poised to make significant contributions to the European laser and biomedical technology landscape.