Elias Arnérs forskargrupp

Publikationer

Alla gruppmedlemmars publikationer

Article: INTERNATIONAL JOURNAL FOR PARASITOLOGY: DRUGS AND DRUG RESISTANCE. 2024;26:100564
Evaluating the amoeba thioredoxin reductase selenoprotein as potential drug target for treatment of Acanthamoeba infections
Loufouma-Mbouaka A; Andor A; Leitsch D; Perez-Serrano J; Arner ESJ; Walochnik J; Martin-Perez T
Journal article: INTERNATIONAL JOURNAL FOR PARASITOLOGY: DRUGS AND DRUG RESISTANCE. 2024;26:100564
Evaluating the amoeba thioredoxin reductase selenoprotein as potential drug target for treatment of Acanthamoeba infections.
Loufouma-Mbouaka A; Andor A; Leitsch D; Pérez-Serrano J; Arnér ESJ; Walochnik J; Martín-Pérez T
Review: CURRENT OPINION IN CHEMICAL BIOLOGY. 2024;83:102522
Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system
Dagnell M; Arner ESJ
Article: EMBO JOURNAL. 2024;43(13):2789-2812
TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation
Marti-Andres P; Finamor I; Torres-Cuevas I; Perez S; Rius-Perez S; Colino-Lage H; Guerrero-Gomez D; Morato E; Marina A; Michalska P; Leon R; Cheng Q; Juranyi EP; Borbenyi-Galambos K; Millan I; Nagy P; Miranda-Vizuete A; Schmidt EE; Martinez-Ruiz A; Arner ESJ; Sastre J
Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2024;218:23
SELENOCYSTEINE VARIANT OF HUMAN PEROXIREDOXIN 2 IS MORE ACTIVE THAN THE WILD TYPE ENZYME
Andor A; Pato ZA; Mohanraj M; Biri-Kovacs B; Kolonics A; Cheng Q; Arner ESJ
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2024;218:8
BEYOND REDUCTION: UNVEILING TRP14'S DUAL ROLE IN CYSTEINE HOMEOSTASIS AND REDOX DYNAMICS
Marti-Andres P; Finamor I; Torres I; Perez S; Rius-Perez S; Colino-Lage H; Guerrero-Gomez D; Morato E; Marina A; Michalska P; Leon R; Cheng Q; Petra Juranyi E; Borbenyi-Galambos K; Millan I; Nagy P; Miranda-Vizuete A; Schmidt EE; Martinez-Ruiz A; Arner ESJ; Sastre J
Article: GENOME BIOLOGY AND EVOLUTION. 2024;16(3):evae041
Ancient Loss of Catalytic Selenocysteine Spurred Convergent Adaptation in a Mammalian Oxidoreductase
Rees J; Sarangi G; Cheng Q; Floor M; Andres AM; Oliva Miguel B; Villa-Freixa J; Arner ESJ; Castellano S
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2024;146(8):5204-5214
Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology
Zeisel L; Felber JG; Scholzen KC; Schmitt C; Wiegand AJ; Komissarov L; Arner ESJ; Thorn-Seshold O
Review: ADVANCES IN CANCER RESEARCH. 2024;162:1-44
Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis.
Arnér ESJ; Schmidt EE
Article: REDOX BIOCHEM CHEM. 2023;5-6:100015
Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children.
Cheff DM; Skröder H; Akhtar E; Cheng Q; Hall MD; Raqib R; Kippler M; Vahter M; Arnér ESJ
Article: REDOX BIOLOGY. 2023;67:102915
Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells
Blandino G; Fiorani M; Canonico B; De Matteis R; Guidarelli A; Montanari M; Buffi G; Coppo L; Arner ESJ; Cantoni O
Article: REDOX BIOLOGY. 2023;67:102897
TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone
Andor A; Mohanraj M; Pato ZA; Uri K; Biri-Kovacs B; Cheng Q; Arner ESJ
Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;208:S118-S119
Beware of the kat among the proteins
Coppo L; Scholz A; Nolan E; Hernandez M; Wang X; Mishra P; Schnell R; Izumi A; Cheng Y; Dagnel M; Cheng Q; Arner E
Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;208:S10
Selenium in control of cell death - unresolved questions regarding the potential roles of glutathione peroxidases and thioredoxin reductases
Arner E
Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;208:S102-S103
The anticancer compounds auranofin, TRi-1 and TRi-2 have distinct cytotoxicity profiles with regards to thioredoxin reductase inhibition
Gencheva R; Cheng Q; Arner E
Preprint: CHEMRXIV. 2023
Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents
Zeisel L; Felber JG; Scholzen KC; Schmitt C; Wiegand AJ; Komissarov L; Arnér ESJ; Thorn-Seshold O
Article: REDOX BIOLOGY. 2023;64:102806
Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant
Roveri A; Di Giacinto F; Rossetto M; Cozza G; Cheng Q; Miotto G; Zennaro L; Paolo MLD; Arner ESJ; De Spirito M; Maiorino M; Ursini F
Article: REDOX BIOLOGY. 2023;63:102719
Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4
Cheff DM; Cheng Q; Guo H; Travers J; Klumpp-Thomas C; Shen M; Arner ESJ; Hall MD
Article: REDOX BIOLOGY. 2023;62:102703
The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
Cheff DM; Huang C; Scholzen KC; Gencheva R; Ronzetti MH; Cheng Q; Hall MD; Arner ESJ
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2023;201:37-38
IS THERE A SUBSTRATE SPECIFICITY OF GLUTATHIONE PEROXIDASE ISOFORMS?
Schwarz M; Cheng Q; Loeser A; Arner ESJ; Kipp AP
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2023;201:39
THE ANTICANCER COMPOUNDS AURANOFIN, TRI-1 AND TRI-2 HAVE DISTINCT CYTOTOXICITY PROFILES WITH REGARDS TO THIOREDOXIN REDUCTASE INHIBITION
Gencheva R; Cheng Q; Arner E
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2023;201:15
TRP14 IS THE CELLULAR CYSTINE REDUCTASE AND ALSO REDUCES CYSTEINYLATED PROTEINS
Marti-Andres P; Isabela; Perez S; Rius-Perez S; Torres-Cuevas I; Colino-Lage H; Guerrero-Gomez D; Morato E; Marina A; Michalska P; Leon R; Cheng Q; Miranda-Vizuete A; Schmidt EE; Martinez-Ruiz A; Arner ESJ; Sastre J
Article: REDOX BIOLOGY. 2023;59:102593
Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides
Schwarz M; Loeser A; Cheng Q; Wichmann-Costaganna M; Schaedel P; Werz O; Arner ESJ; Kipp AP
Preprint: CHEMRXIV. 2023
Bifunctional, piperazine-fused cyclic disulfides for oxidoreductase-activated cellular proagents
Zeisel L; Felber JG; Scholzen KC; Schmitt C; Wiegand AJ; Komissarov L; Arnér ESJ; Thorn-Seshold O
Preprint: BIORXIV. 2023
Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase
Rees J; Sarangi G; Cheng Q; Floor M; Andrés A; Miguel BO; Villà-Freixa J; Arnér ESJ; Castellano S
Article: FRONTIERS IN MICROBIOLOGY. 2023;14:1198473
Novel gold(III)-dithiocarbamate complex targeting bacterial thioredoxin reductase: antimicrobial activity, synergy, toxicity, and mechanistic insights
Ratia C; Ballen V; Gabasa Y; Soengas RG; Velasco-de Andres M; Iglesias MJ; Cheng Q; Lozano F; Arner ESJ; Lopez-Ortiz F; Soto SM
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S50
Probing Toxic Metals and Metalloids in Redox Biology using Synchrotron X-rays
George G; Pickering I; Rengifo EM; Dolgova N; Cheng Q; Arner E
Review: FREE RADICAL BIOLOGY AND MEDICINE. 2022;190:320-338
Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases
Gencheva R; Cheng Q; Arner ESJ
Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2022;189:32-33
A mechanistic dissection of HyPer7, an ultrasensitive pH-independent biosensor
Daria E; Ekaterina B; Gerardo F-S; Qing C; Elias A; Joris M
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(6):e004458
Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress
Renken S; Nakajima T; Magalhaes I; Mattsson J; Lundqvist A; Arner ESJ; Kiessling R; Wickstrom SL
Article: ELIFE. 2022;11:e74549
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
James J; Chen Y; Hernandez CM; Forster F; Dagnell M; Cheng Q; Saei AA; Gharibi H; Lahore GF; astrand A; Malhotra R; Malissen B; Zubarev RA; Arner ESJ; Holmdahl R
Article: CHEM. 2022;8(5):1493-1517
Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe
Zeisel L; Felber JG; Scholzen KC; Poczka L; Cheff D; Maier MS; Cheng Q; Shen M; Hall MD; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O
Article: REDOX BIOLOGY. 2022;51:102278
Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus
Fata F; Gencheva R; Cheng Q; Lullo R; Ardini M; Silvestri I; Gabriele F; Ippoliti R; Bulman CA; Sakanari JA; Williams DL; Arner ESJ; Angelucci F
Article: NATURE COMMUNICATIONS. 2022;13(1):1754
Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically
Felber JG; Poczka L; Scholzen KC; Zeisel L; Maier MS; Busker S; Theisen U; Brandstaedter C; Becker K; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O
Preprint: CHEMRXIV. 2022
Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe
Zeisel L; Felber JG; Poczka L; Scholzen K; Cheff D; Maier MS; Cheng Q; Shen M; Hall MD; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2022;180:68
Development of a chemical probe that selectively images the activity of mammalian Thioredoxin Reductase 1
Zeisel L; Felber J; Poczka L; Scholzen K; Maier M; Cheng Q; Arner E; Thorn-Seshold J; Thorn-Seshold O
Preprint: CHEMRXIV. 2022
Cyclic 5-Membered Disulfides Are Not Selective Substrates of Thioredoxin Reductase, but Are Opened Nonspecifically
Felber J; Poczka L; Scholzen K; Zeisel L; Maier MS; Busker S; Theisen U; Brandstädter C; Becker K; Arnér E; Ahlfeld J; Thorn-Seshold O
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2022;62:177-196
Thioredoxin Reductase Inhibition for Cancer Therapy
Gencheva R; Arner ESJ
Book chapter: REDOX CHEMISTRY AND BIOLOGY OF THIOLS. 2022;p. 197-218
Chapter 10 Thioredoxin and glutathione reductases
Arnér ESJ
Article: METHODS IN ENZYMOLOGY. 2022;662:95-118
Expressing recombinant selenoproteins using redefinition of a single UAG codon in an RF1-depleted E. coli host strain.
Cheng Q; Arnér ESJ
Conference publication: INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE. 2022;63(7)
The potential role of rod-derived cone viability factor long (RdCVFL) in treating retinitis pigmentosa as a thioredoxin-like protein
Ren X; Holmgren A; Arner ESJ; Leveillard TD
Preprint: BIORXIV. 2021
Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation
James J; Chen Y; Hernandez C; Forster F; Dagnell M; Cheng Q; Saei A; Gharibi H; Lahore GF; Åstrand A; Malhotra R; Malissen B; Zubarev R; Arnér ESJ; Holmdahl R
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2021;177:s66
TRP14 deficiency markedly reduces the inflammatory response in acute pancreatitis through Nrf2 activation
Marti-Andres P; Perez S; Finamor I; Torres-Cuevas I; Rius-Perez S; Martinez-Ruiz A; Schmidt E; Arner ESJ; Sastre J
Article: ECLINICALMEDICINE. 2021;42:101180
Evaluation of dithiothreitol-oxidizing capacity (DOC) as a serum biomarker for chronic hepatitis B in patients exhibiting normal alanine aminotransferase levels: a pilot study towards better monitoring of disease
Yang L; Zhang Y; Zhang K; Liu Z; He T; Zheng X; Li L; Arner ESJ; Zhang Z; Zhang J
Article: REDOX BIOLOGY. 2021;48:102184
Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin
Sabatier P; Beusch CM; Gencheva R; Cheng Q; Zubarev R; Arner ESJ
Review: ORPHANET JOURNAL OF RARE DISEASES. 2021;16(1):446
Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities
Cheff DM; Muotri AR; Stockwell BR; Schmidt EE; Ran Q; Kartha RV; Johnson SC; Mittal P; Arner ESJ; Wigby KM; Hall MD; Ramesh SK
Article: REDOX BIOLOGY. 2021;46:102070
Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein
Cheng Q; Roveri A; Cozza G; Bordin L; Rohn I; Schwerdtle T; Kipp A; Ursini F; Maiorino M; Miotto G; Arner ESJ
Preprint: CHEMRXIV. 2021
Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe
Zeisel L; Felber JG; Poczka L; Scholzen K; Maier MS; Cheng Q; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O
Preprint: CHEMRXIV. 2021
Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe
Zeisel L; Felber JG; Poczka L; Scholzen K; Maier MS; Cheng Q; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2021;143(23):8791-8803
Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif
Felber JG; Zeisel L; Poczka L; Scholzen K; Busker S; Maier MS; Theisen U; Brandstaedter C; Becker K; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O
Other: REDOX BIOLOGY. 2021;41:101991
In Memoriam Arne Holmgren (1940-2020)
Arner ESJ
Other: FREE RADICAL BIOLOGY AND MEDICINE. 2021;167:III-IV
In Memoriam Arne Holmgren (1940-2020)
Arner ESJ
Editorial comment: SCIENCE ADVANCES. 2021;7(17):eabe7006
Comment on "Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity"
Doka E; Arner ESJ; Schmidt EE; Dick TP; van der Vliet A; Yang J; Szatmari R; Ditroi T; Wallace JL; Cirino G; Olson K; Motohashi H; Fukuto JM; Pluth MD; Feelisch M; Akaike T; Wink DA; Ignarro LJ; Nagy P
Preprint: PREPRINTS.ORG. 2021
Development of Therapies for Rare Genetic Disorders of GPX4: Roadmap and Opportunities
Cheff D; Muotri A; Stockwell B; Schmidt E; Ran Q; Kartha R; Johnson S; Mittal P; Arnér E; Wigby K; Hall M; Ramesh S
Preprint: CHEMRXIV. 2021
Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif
Felber J; Zeisel L; Poczka L; Scholzen K; Busker S; Maier M; Theisen U; Brandstädter C; Becker K; Arnér E; Thorn-Seshold J; Thorn-Seshold O
Preprint: CHEMRXIV. 2021
Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif
Felber J; Zeisel L; Poczka L; Scholzen K; Busker S; Maier MS; Theisen U; Brandstädter C; Becker K; Arnér E; Thorn-Seshold J; Thorn-Seshold O
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2021;165:6-7
The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth factor responses
Arner E
Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2021;165:5-6
The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth factor responses
Arnér E
Article: NATURE COMMUNICATIONS. 2021;12(1):1296
System-wide identification and prioritization of enzyme substrates by thermal analysis
Saei AA; Beusch CM; Sabatier P; Wells JA; Gharibi H; Meng Z; Chernobrovkin A; Rodin S; Nareoja K; Thorsell A-G; Karlberg T; Cheng Q; Lundstrom SL; Gaetani M; Vegvari A; Arner ESJ; Schuler H; Zubarev RA
Preprint: RESEARCH SQUARE. 2021
SIESTA as a universal unbiased proteomics approach for identification and prioritization of enzyme substrates
Saei AA; Beusch C; Sabatier P; Wells JA; Gharibi H; Meng Z; Chernobrovkin A; Rodin S; Näreoja K; Thorsell A-G; Karlberg T; Cheng Q; Lundström S; Gaetani M; Végvári Á; Arnér ESJ; Schüler H; Zubarev R
Article: ANTIOXIDANTS. 2021;10(1):111
Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H₂O₂ Together with Bicarbonate
Dagnell M; Cheng Q; Arner ESJ
Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;264:289-309
Effects of Mammalian Thioredoxin Reductase Inhibitors.
Arnér ESJ
Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2021;2021:6621292
Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases
Hossain MF; Bodnar Y; Klein C; Salas CO; Arner ESJ; Gellert M; Lillig CH
Preprint: CHEMRXIV. 2020
Cyclic 5-Membered Disulfides Are Not Selective Substrates of Thioredoxin Reductase, but Are Opened Nonspecifically by Thiols
Felber J; Poczka L; Busker S; Theisen U; Zeisel L; Maier MS; Loy K; Brandstädter C; Scholzen K; Becker K; Arnér E; Ahlfeld J; Thorn-Seshold O
Preprint: CHEMRXIV. 2020
Cyclic 5-Membered Disulfides Are Not Selective Substrates of Thioredoxin Reductase, but Are Opened Nonspecifically by Thiols
Felber J; Poczka L; Busker S; Theisen U; Zeisel L; Maier MS; Loy K; Brandstädter C; Scholzen K; Becker K; Arnér E; Ahlfeld J; Thorn-Seshold O
Article: REDOX BIOLOGY. 2020;36:101646
To inhibit TrxR1 is to inactivate STAT3-Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors
Busker S; Page B; Arner ESJ
Article: BREAST CANCER RESEARCH. 2020;22(1):80
Identification and targeting of selective vulnerability rendered by tamoxifen resistance
Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arner ESJ; Hartman J; Selivanova G
Article: NEUROTHERAPEUTICS. 2020;17(3):1142-1152
Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate
Carlstrom KE; Chinthakindi PK; Espinosa B; Al Nimer F; Arner ESJ; Arvidsson PI; Piehl F; Johansson K
Article: GENOME RESEARCH. 2020;30(7):1060-1072
Functional annotation of human long noncoding RNAs via molecular phenotyping
Ramilowski JA; Yip CW; Agrawal S; Chang J-C; Ciani Y; Kulakovskiy IV; Mendez M; Ooi JLC; Ouyang JF; Parkinson N; Petri A; Roos L; Severin J; Yasuzawa K; Abugessaisa I; Akalin A; Antonov IV; Arner E; Bonetti A; Bono H; Borsari B; Brombacher F; Cameron CJF; Cannistraci CV; Cardenas R; Cardon M; Chang H; Dostie J; Ducoli L; Favorov A; Fort A; Garrido D; Gil N; Gimenez J; Guler R; Handoko L; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto K; Hayatsu N; Heutink P; Hirose T; Imada EL; Itoh M; Kaczkowski B; Kanhere A; Kawabata E; Kawaji H; Kawashima T; Kelly ST; Kojima M; Kondo N; Koseki H; Kouno T; Kratz A; Kurowska-Stolarska M; Kwon ATJ; Leek J; Lennartsson A; Lizio M; Lopez-Redondo F; Luginbuhl J; Maeda S; Makeev VJ; Marchionni L; Medvedeva YA; Minoda A; Mueller F; Munoz-Aguirre M; Murata M; Nishiyori H; Nitta KR; Noguchi S; Noro Y; Nurtdinov R; Okazaki Y; Orlando V; Paquette D; Parr CJC; Rackham OJL; Rizzu P; Martinez DFS; Sandelin A; Sanjana P; Semple CAM; Shibayama Y; Sivaraman DM; Suzuki T; Szumowski SC; Tagami M; Taylor MS; Terao C; Thodberg M; Thongjuea S; Tripathi V; Ulitsky I; Verardo R; Vorontsov IE; Yamamoto C; Young RS; Baillie JK; Forrest ARR; Guigo R; Hoffman MM; Hon CC; Kasukawa T; Kauppinen S; Kere J; Lenhard B; Schneider C; Suzuki H; Yagi K; de Hoon MJL; Shin JW; Carninci P
Article: REDOX BIOLOGY. 2020;32:101491
Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Saei AA; Gullberg H; Sabatier P; Beusch CM; Johansson K; Lundgren B; Arvidsson PI; Arner ESJ; Zubarev RA
Article: SCIENCE ADVANCES. 2020;6(12):eaax7945
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grander D; Arner ESJ; Tamm KP; Page BDG
Article: ACS INFECTIOUS DISEASES. 2020;6(3):393-405
Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis
Lyu H; Petukhov PA; Banta PR; Jadhav A; Lea WA; Cheng Q; Arner ESJ; Simeonov A; Thatcher GRJ; Angelucci F; Williams DL
Article: INORGANIC CHEMISTRY. 2020;59(5):2711-2718
Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase
Pickering IJ; Cheng Q; Rengifo EM; Nehzati S; Dolgova NV; Kroll T; Sokaras D; George GN; Arner ESJ
Review: ESSAYS IN BIOCHEMISTRY. 2020;64(1):45-53
Common modifications of selenocysteine in selenoproteins
Arner ESJ
Article: SCIENCE ADVANCES. 2020;6(1):eaax8358
Control of protein function through oxidation and reduction of persulfidated states
Doka E; Ida T; Dagnell M; Abiko Y; Luong NC; Balog N; Takata T; Espinosa B; Nishimura A; Cheng Q; Funato Y; Miki H; Fukuto JM; Prigge JR; Schmidt EE; Arner ESJ; Kumagai Y; Akaike T; Nagy P
Book chapter: OXIDATIVE STRESS. 2020;p. 639-667
Chapter 31 Perspectives of TrxR1-based cancer therapies
Arnér ESJ
Article: REDOX BIOLOGY. 2020;28:101335
Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone
Shu N; Cheng Q; Arner ESJ; Davies MJ
Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):17501
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system (vol 9, 9841, 2019)
Selvaraju K; Mofers A; Pellegrini P; Salomonsson J; Ahlner A; Morad V; Hillert E-K; Espinosa B; Arner ESJ; Jensen L; Malmstrom J; Turkina MV; D'Arcy P; Walters MA; Sunnerhagen M; Linder S
Book chapter: SELENIUM RESEARCH FOR ENVIRONMENT AND HUMAN HEALTH: PERSPECTIVES, TECHNOLOGIES AND ADVANCEMENTS. 2019;p. 153-154
New developments in recombinant selenoprotein production
Cheng Q; Arnér ESJ
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2019;31(9):664-670
Which Antioxidant System Shapes Intracellular H₂O₂ Gradients?
Mishina NM; Bogdanova YA; Ermakova YG; Panova AS; Kotova DA; Bilan DS; Steinhorn B; Arner ES; Michel T; Belousov VV
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(33):12330-12338
Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades
Dagnell M; Cheng Q; Rizvi SHM; Pace PE; Boivin B; Winterbourn CC; Arner ESJ
Article: SCIENTIFIC REPORTS. 2019;9(1):9841
Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system
Selvaraju K; Mofers A; Pellegrini P; Salomonsson J; Ahlner A; Morad V; Hillert E-K; Espinosa B; Arner ESJ; Jensen L; Malmstrom J; Turkina MV; D'Arcy P; Walters MA; Sunnerhagen M; Linder S
Article: BIOCHIMIE. 2019;162:46-54
Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug
Zhang X; Selvaraju K; Saei AA; D'Arcy P; Zubarev RA; Arner ESJ; Linder S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(23):11408-11417
TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy
McLoughlin MR; Orlicky DJ; Prigge JR; Krishna P; Talago EA; Cavigli IR; Eriksson S; Miller CG; Kundert JA; Sayin VI; Sabol RA; Heinemann J; Brandenberger LO; Iverson SV; Bothner B; Papagiannakopoulos T; Shearn CT; Arner ESJ; Schmidt EE
Article: DIABETES. 2019;68(4):709-723
Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate
Katsu-Jimenez Y; Vazquez-Calvo C; Maffezzini C; Halldin M; Peng X; Freyer C; Wredenberg A; Gimenez-Cassina A; Wedell A; Arner ESJ
Review: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(4):544-553
Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways
Espinosa B; Arner ESJ
Article: METHODS IN MOLECULAR BIOLOGY. 2019;2007:51-77
ProPerDP: A Protein Persulfide Detection Protocol.
Dóka É; Arnér ESJ; Schmidt EE; Nagy P
Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;127:248-261
NADPH-dependent and -independent disulfide reductase systems
Miller CG; Holmgren A; Arner ESJ; Schmidt EE
Editorial comment: FREE RADICAL BIOLOGY AND MEDICINE. 2018;127:1-2
Selenium and selenoproteins in (redox) signaling, diseases, and animal models-200 year anniversary issue
Brigelius-Flohe R; Arner ESJ
Editorial comment: BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2018;1862(11):2331-2332
Selenium research in biochemistry and biophysics-200 year anniversary issue Preface
Arner ESJ; Brigelius-Flohe R
Published conference paper: BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2018;1862(11):2511-2517
Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase
Gencheva R; Cheng Q; Arner ESJ
Preprint: BIORXIV. 2018
System-wide identification and prioritization of enzyme substrates by thermal analysis (SIESTA)
Saei AA; Beusch C; Sabatier P; Wells JA; Chernobrovkin A; Rodin S; Näreoja K; Thorsell A-G; Karlberg T; Cheng Q; Lundström S; Gaetani M; Végvári Á; Arnér ESJ; Schüler H; Zubarev R
Article: ACS CHEMICAL BIOLOGY. 2018;13(8):2190-2202
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry
Silvestri I; Lyu H; Fata F; Boumis G; Miele AE; Ardini M; Ippoliti R; Bellelli A; Jadhav A; Lea WA; Simeonov A; Cheng Q; Arner ESJ; Thatcher GRJ; Petukhov PA; Williams DL; Angelucci F
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S46-S47
Thioredoxin related protein of 14 kDa (TRP14, TXNDC17) represses Nrf2 and NFκB activities and augments HIF activation
Fernandez BE; Pader I; Cebula M; Johansson K; Arner E
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S46
Screening for novel inhibitors of glutathione peroxidase
Cheff DM; Cheng Q; Hall MD; Arner E
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S31
Specific irreversible targeting of the selenoprotein thioredoxin reductase 1 in cancer therapy
Arner ESJ
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S34
Thioredoxin-related protein of 14 kDa may directly reduce protein cysteinylation motifs
Marti-Andres P; Finamor I; Espinosa B; Perez S; Rius-Perez S; Talens-Visconti R; Leon R; Martinez-Ruiz A; Arner ESJ; Sastre J
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S36
Bicarbonate is required for hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxin
Dagnell M; Cheng Q; Pace PE; Hampton MB; Winterbourn CC; Arner ESJ
Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(428):eaaf7444
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Stafford WC; Peng X; Olofsson MH; Zhang X; Luci DK; Lu L; Cheng Q; Tresaugues L; Dexheimer TS; Coussens NP; Augsten M; Ahlzen H-SM; Orwar O; Ostman A; Stone-Elander S; Maloney DJ; Jadhav A; Simeonov A; Linder S; Arner ESJ
Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;115:484-496
The A to Z of modulated cell patterning by mammalian thioredoxin reductases
Dagnell M; Schmidt EE; Arner ESJ
Article: CELL. 2018;172(3):409-422.e21
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Ingold I; Berndt C; Schmitt S; Doll S; Poschmann G; Buday K; Roveri A; Peng X; Freitas FP; Seibt T; Mehr L; Aichler M; Walch A; Lamp D; Jastroch M; Miyamoto S; Wurst W; Ursini F; Amer ESJ; Fradejas-Villar N; Schweizer U; Zischka H; Angeli JPF; Conrad M
Article: METHODS IN MOLECULAR BIOLOGY. 2018;1661:301-309
Selective Evaluation of Thioredoxin Reductase Enzymatic Activities.
Arnér ESJ
Article: METHODS IN MOLECULAR BIOLOGY. 2018;1661:231-240
Overexpression of Recombinant Selenoproteins in E. coli.
Cheng Q; Arnér ESJ
Conference publication: FEBS OPEN BIO. 2018;8:58
Selenoproteins as unique regulators of redox signaling pathways
Arner ES
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2017;112:24
Selenium utilization by GPX4 was an evolutionary requirement to prevent hydroperoxide-induced ferroptosis
Ingold I; Berndt C; Schmitt S; Doll S; Poschmann G; Roveri A; Peng X; Freitas FP; Aichler M; Jastroch M; Ursini F; Arner ESJ; Fradejas-Villar N; Schweizer U; Zischka H; Angeli JPF; Conrad M
Book chapter: HYDROGEN PEROXIDE METABOLISM IN HEALTH AND DISEASE. 2017;p. 387-402
H 2 O 2 , Thioredoxin, and Signaling
Arnér ESJ
Article: EBIOMEDICINE. 2017;24:257-266
Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes
Qin X-Y; Hara M; Arner E; Kawaguchi Y; Inoue I; Tatsukawa H; Furutani Y; Nagatsuma K; Matsuura T; Wei F; Kikuchi J; Sone H; Daub C; Kawaji H; Lassmann T; Itoh M; Suzuki H; Carninci P; Hayashizaki Y; Kokudo N; Forrest ARR; Kojima S
Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(10):1564-1569
Abdominal subcutaneous adipose tissue cellularity in men and women
Andersson DP; Arner E; Hogling DE; Ryden M; Arner P
Article: NATURE BIOTECHNOLOGY. 2017;35(9):872-878
An integrated expression atlas of miRNAs and their promoters in human and mouse
de Rie D; Abugessaisa I; Alam T; Arner E; Arner P; Ashoor H; Astrom G; Babina M; Bertin N; Burroughs AM; Carlisle AJ; Daub CO; Detmar M; Deviatiiarov R; Fort A; Gebhard C; Goldowitz D; Guhl S; Ha TJ; Harshbarger J; Hasegawa A; Hashimoto K; Herlyn M; Heutink P; Hitchens KJ; Hon CC; Huang E; Ishizu Y; Kai C; Kasukawa T; Klinken P; Lassmann T; Lecellier C-H; Lee W; Lizio M; Makeev V; Mathelier A; Medvedeva YA; Mejhert N; Mungall CJ; Noma S; Ohshima M; Okada-Hatakeyama M; Persson H; Rizzu P; Roudnicky F; Saetrom P; Sato H; Severin J; Shin JW; Swoboda RK; Tarui H; Toyoda H; Vitting-Seerup K; Winteringham L; Yamaguchi Y; Yasuzawa K; Yoneda M; Yumoto N; Zabierowski S; Zhang PG; Wells CA; Summers KM; Kawaji H; Sandelin A; Rehli M; Hayashizaki Y; Carninci P; Forrest ARR; de Hoon MJL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(35):14371-14380
Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H₂O₂ exposure
Dagnell M; Pace PE; Cheng Q; Frijhoff J; Ostman A; Arner ESJ; Hampton MB; Winterbourn CC
Article: SCIENTIFIC DATA. 2017;4:170112
Data Descriptor: FANTOM5 CAGE profiles of human and mouse samples
Noguchi S; Arakawa T; Fukuda S; Furuno M; Hasegawa A; Hori F; Ishikawa-Kato S; Kaida K; Kaiho A; Kanamori-Katayama M; Kawashima T; Kojima M; Kubosaki A; Manabe R-I; Murata M; Nagao-Sato S; Nakazato K; Ninomiya N; Nishiyori-Sueki H; Noma S; Saijyo E; Saka A; Sakai M; Simon C; Suzuki N; Tagami M; Watanabe S; Yoshida S; Arner P; Axton RA; Babina M; Baillie JK; Barnett TC; Beckhouse AG; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Carlisle AJ; Clevers HC; Davis CA; Detmar M; Dohi T; Edge ASB; Edinger M; Ehrlund A; Ekwall K; Endoh M; Enomoto H; Eslami A; Fagiolini M; Fairbairn L; Farach-Carson MC; Faulkner GJ; Ferrai C; Fisher ME; Forrester LM; Fujita R; Furusawa J-I; Geijtenbeek TB; Gingeras T; Goldowitz D; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Hasegawa Y; Herlyn M; Heutink P; Hitchens KJ; Hume DA; Ikawa T; Ishizu Y; Kai C; Kawamoto H; Kawamura YI; Kempfle JS; Kenna TJ; Kere J; Khachigian LM; Kitamura T; Klein S; Klinken SP; Knox AJ; Kojima S; Koseki H; Koyasu S; Lee W; Lennartsson A; Mackay-sim A; Mejhert N; Mizuno Y; Morikawa H; Morimoto M; Moro K; Morris KJ; Motohashi H; Mummery CL; Nakachi Y; Nakahara F; Nakamura T; Nakamura Y; Nozaki T; Ogishima S; Ohkura N; Ohno H; Ohshima M; Okada-Hatakeyama M; Okazaki Y; Orlando V; Ovchinnikov DA; Passier R; Patrikakis M; Pombo A; Pradhan-Bhatt S; Qin X-Y; Rehli M; Rizzu P; Roy S; Sajantila A; Sakaguchi S; Sato H; Satoh H; Savvi S; Saxena A; Schmidl C; Schneider C; Schulze-Tanzil GG; Schwegmann A; Sheng G; Shin JW; Sugiyama D; Sugiyama T; Summers KM; Takahashi N; Takai J; Tanaka H; Tatsukawa H; Tomoiu A; Toyoda H; van de Wetering M; van den Berg LM; Verardo R; Vijayan D; Wells CA; Winteringham LN; Wolvetang E; Yamaguchi Y; Yamamoto M; Yanagi-Mizuochi C; Yoneda M; Yonekura Y; Zhang PG; Zucchelli S; Abugessaisa I; Arner E; Harshbarger J; Kondo A; Lassmann T; Lizio M; Sahin S; Sengstag T; Severin J; Shimoji H; Suzuki M; Suzuki H; Kawai J; Kondo N; Itoh M; Daub CO; Kasukawa T; Kawaji H; Carninci P; Forrest ARR; Hayashizaki Y
Article: REDOX BIOLOGY. 2017;12:403-409
Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells
Kipp AP; Deubel S; Arner ESJ; Johansson K
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2017;108:S8-S9
Molecular Mechanisms of Regulated Cell Pattering by the Mammalian Thioredoxin System
Arner ES
Article: CELL REPORTS. 2017;19(13):2771-2781
Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
Prigge JR; Coppo L; Martin SS; Ogata F; Miller CG; Bruschwein MD; Orlicky DJ; Shearn CT; Kundert JA; Lytchier J; Herr AE; Mattsson A; Taylor MP; Gustafsson TN; Arner ESJ; Holmgren A; Schmidt EE
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2017;106:270-277
Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy
Kudin AP; Baron G; Zsurka G; Hampel KG; Elger CE; Grote A; Weber Y; Lerche H; Thiele H; Nuernberg P; Schulz H; Ruppert A-K; Sander T; Cheng Q; Arner ESJ; Schomburg L; Seeher S; Fradejas-Villar N; Schweizer U; Kunz WS
Article: BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2017;1861(5):1177-1189
Rutin protects against H₂O₂-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress
Sthijns MMJPE; Schiffers PM; Janssen GM; Lemmens KJA; Ides B; Vangrieken P; Bouwman FG; Mariman EC; Pader I; Arner ESJ; Johansson K; Bast A; Haenen GRMM
Corrigendum: CELL DEATH AND DISEASE. 2017;8(4):e2751
APR-246/PRIMA-1^MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase (vol 4, e881, 2013)
Peng X; Zhang M-Q; Conserva F; Hosny G; Selivanova G; Bykov VJN; Arner ESJ; Wiman KG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(13):5476-5487
Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation
Cheng Q; Arner ESJ
Article: EMBO JOURNAL. 2017;36(5):693-702
Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER
Poet GJ; Oka OBV; van Lith M; Cao Z; Robinson PJ; Pringle MA; Arner ESJ; Bulleid NJ
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2017;26(6):229-246
Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution
Johansson K; Cebula M; Rengby O; Dreij K; Carlstrom KE; Sigmundsson K; Piehl F; Arner ESJ
Book chapter: ENCYCLOPEDIA OF CANCER. 2017;p. 4508-4511
Thioredoxin System
Arnér ESJ; Holmgren A
Book chapter: SELENIUM IN PLANTS: PLANT ECOPHYSIOLOGY. 2017;p. 123-139
Selenium Metabolism in Herbivores and Higher Trophic Levels Including Mammals
Schomburg L; Arnér ESJ
Review: ADVANCES IN CANCER RESEARCH. 2017;136:139-151
Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy
Arner ESJ
Article: EJNMMI RESEARCH. 2016;6(1):58
Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake
Cheng Q; Wallberg H; Grafstrom J; Lu L; Thorell J-O; Olofsson MH; Linder S; Johansson K; Tegnebratt T; Arner ESJ; Stone-Elander S; Ahlzen H-SM; Stahl S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(46):24036-24040
Selenoprotein Gene Nomenclature
Gladyshev VN; Arner ES; Berry MJ; Brigelius-Flohe R; Bruford EA; Burk RF; Carlson BA; Castellano S; Chavatte L; Conrad M; Copeland PR; Diamond AM; Driscoll DM; Ferreiro A; Flohe L; Green FR; Guigo R; Handy DE; Hatfield DL; Hesketh J; Hoffmann PR; Holmgren A; Hondal RJ; Howard MT; Huang K; Kim H-Y; Kim IY; Koehrle J; Krol A; Kryukov GV; Lee BJ; Lee BC; Lei XG; Liu Q; Lescure A; Lobanov AV; Loscalzo J; Maiorino M; Mariotti M; Sandeep Prabhu K; Rayman MP; Rozovsky S; Salinas G; Schmidt EE; Schomburg L; Schweizer U; Simonovic M; Sunde RA; Tsuji PA; Tweedie S; Ursini F; Whanger PD; Zhang Y
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S6
THIOREDOXIN REDUCTASE 1 (TrxR1) LINKS CELLULAR SIGNALING PATHWAYS CONTROLLING CELLULAR PHENOTYPE TO H₂O₂ MODULATION, NITROSYLATION, AND PERSULFIDATION PATHWAYS
Arner ESJ
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S47
Thioredoxin Reductase 1 Directly Protects Protein Tyrosine Phosphatase 1B from Inactivation by H₂O₂
Dagnell M; Pace P; Cheng Q; Frijhoff J; Ostman A; Arner E; Hampton M; Winterbourn C
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;99:426-435
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms
Zhang L; Cheng Q; Zhang L; Wang Y; Merrill GF; Ilani T; Fass D; Arner ESJ; Zhang J
Article: SCIENTIFIC REPORTS. 2016;6:33274
Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors
Miraglia E; Nylen F; Johansson K; Arner E; Cebula M; Farmand S; Ottosson H; Stromberg R; Gudmundsson GH; Agerberth B; Bergman P
Conference publication: TOXICOLOGY LETTERS. 2016;258:S124-S125
Rutin protects against endothelial dysfunction and induces nrf2-mediated adaptation in huvecs exposed to oxidative stress
Sthijns M; Schiffers P; Janssen G; Lemmens K; Ides B; Vangrieken P; Bouwman F; Mariman E; Pader I; Arner E; Johansson K; Bast A; Haenen G
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;97:375-385
Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance
Engelman R; Ziv T; Arner ESJ; Benhar M
Article: ONCOTARGET. 2016;7(26):40233-40251
Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
Kaminska KK; Bertrand HC; Tajima H; Stafford WC; Cheng Q; Chen W; Wells G; Arner ESJ; Chew E-H
Article: SCIENTIFIC REPORTS. 2016;6:28080
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness
Peng X; Gimenez-Cassina A; Petrus P; Conrad M; Ryden M; Arner ESJ
Article: MOLECULAR PHARMACEUTICS. 2016;13(6):2010-2025
Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells
van Gisbergen MW; Cebula M; Zhang J; Ottosson-Wadlund A; Dubois L; Lambin P; Tew KD; Townsend DM; Haenen GRMM; Drittij-Repders M-J; Saneyoshi H; Araki M; Shishido Y; Ito Y; Arner ESJ; Abe H; Morgenstern R; Johansson K
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;94:110-120
Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities
Xu J; Cheng Q; Arner ESJ
Book chapter: SELENIUM. 2016;p. 199-209
Thioredoxin Reductase 1 as an Anticancer Drug Target
Schmidt EE; Arnér ESJ
Article: SCIENCE ADVANCES. 2016;2(1):e1500968
A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems
Doka E; Pader I; Biro A; Johansson K; Cheng Q; Ballago K; Prigge JR; Pastor-Flores D; Dick TP; Schmidt EE; Arner ESJ; Nagy P
Review: PHYSIOLOGICAL REVIEWS. 2016;96(1):307-364
PARADOXICAL ROLES OF ANTIOXIDANT ENZYMES: BASIC MECHANISMS AND HEALTH IMPLICATIONS
Lei XG; Zhu J-H; Cheng W-H; Bao Y; Ho Y-S; Reddi AR; Holmgren A; Arner ESJ
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2015;23(10):823-853
TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System
Cebula M; Schmidt EE; Arner ESJ
Article: ONCOTARGET. 2015;6(18):16488-16506
Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells
Sachweh MCC; Stafford WC; Drummond CJ; McCarthy AR; Higgins M; Campbell J; Brodin B; Arner ESJ; Lain S
Article: NATURE COMMUNICATIONS. 2015;6:6479
Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver
Eriksson S; Prigge JR; Talago EA; Arner ESJ; Schmidt EE
Article: CELL DEATH AND DISEASE. 2015;6(1):e1616
The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death
Xu J; Eriksson SE; Cebula M; Sandalova T; Hedstrom E; Pader I; Cheng Q; Myers CR; Antholine WE; Nagy P; Hellman U; Selivanova G; Lindqvist Y; Arner ESJ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1840(7):2105-2111
Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury
Sun K; Eriksson SE; Tan Y; Zhang L; Arner ESJ; Zhang J
Article: MOLECULAR PHARMACOLOGY. 2014;85(6):932-945
The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death
Wang X; Stafford W; Mazurkiewicz M; Fryknas M; Brjnic S; Zhang X; Gullbo J; Larsson R; Arner ESJ; D'Arcy P; Linder S
Article: CELL DEATH AND DISEASE. 2014;5(5):e1235
Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H₂O₂
Peng X; Mandal PK; Kaminskyy VO; Lindqvist A; Conrad M; Arner ESJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(19):6964-6969
Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase
Pader I; Sengupta R; Cebula M; Xu J; Lundberg JO; Holmgren A; Johansson K; Arner ESJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(19):6976-6981
Redox active motifs in selenoproteins
Li F; Lutz PB; Pepelyayeva Y; Arner ESJ; Bayse CA; Rozovsky S
Article: ACTA OTO-LARYNGOLOGICA. 2014;134(5):448-454
Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures
Dammeyer P; Hellberg V; Wallin I; Laurell G; Shoshan M; Ehrsson H; Arner ESJ; Kirkegaard M
Article: BLOOD. 2014;123(17):e46-e57
High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis
Prasad P; Ronnerblad M; Arner E; Itoh M; Kawaji H; Lassmann T; Daub CO; Forrest ARR; Lennartsson A; Ekwall K
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;69:67-76
Sepp1^UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1
Kurokawa S; Eriksson S; Rose KL; Wu S; Motley AK; Hill S; Winfrey VP; McDonald WH; Capecchi MR; Atkins JF; Arner ESJ; Hill KE; Burk RF
Article: CELL DEATH AND DIFFERENTIATION. 2014;21(4):612-623
sROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis
Shi Y; Nikulenkov F; Zawacka-Pankau J; Li H; Gabdoulline R; Xu J; Eriksson S; Hedstroem E; Issaeva N; Kel A; Arner ESJ; Selivanova G
Book chapter: ENCYCLOPEDIA OF CANCER. 2014;p. 1-4
Thioredoxin System
Arnér ESJ; Holmgren A
Article: NUCLEIC ACIDS RESEARCH (NAR). 2013;41(21):9800-9811
Wobble decoding by the Escherichia coli selenocysteine insertion machinery
Xu J; Croitoru V; Rutishauser D; Cheng Q; Arner ESJ
Article: CELL DEATH AND DISEASE. 2013;4(10):e881
APR-246/PRIMA-1^MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase
Peng X; Zhang M-Q; Conserva F; Hosny G; Selivanova G; Bykov VJN; Arner ESJ; Wiman KG
Book chapter: SELENIUM IN THE ENVIRONMENT AND HUMAN HEALTH. 2013;p. 167-169
The selenoprotein thioredoxin reductase as a key regulator of cellular signaling pathways
Arnér E
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2013;63:369-380
A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification
Iverson SV; Eriksson S; Xu J; Prigge JR; Talago EA; Meade TA; Meade ES; Capecchi MR; Arner ESJ; Schmidt EE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13398-13403
Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling
Dagnell M; Frijhoff J; Pader I; Augsten M; Boivin B; Xu J; Mandal PK; Tonks NK; Hellberg C; Conrad M; Arner ESJ; Ostman A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2013;60:183-194
Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping
Myers JM; Cheng Q; Antholine WE; Kalyanaraman B; Filipovska A; Arner ESJ; Myers CR
Editorial comment: BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2013;1830(6):III-IV
BBA General Subjects - Changing of the Guard at the Publishing Palace
Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(16):11312-11324
Multilevel Regulation of 2-Cys Peroxiredoxin Reaction Cycle by S-Nitrosylation
Engelman R; Weisman-Shomer P; Ziv T; Xu J; Arner ESJ; Benhar M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(14):10002-10011
The Rare TXNRD1_v3 ("v3") Splice Variant of Human Thioredoxin Reductase 1 Protein Is Targeted to Membrane Rafts by N-Acylation and Induces Filopodia Independently of Its Redox Active Site Integrity
Cebula M; Moolla N; Capovilla A; Arner ESJ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1830(3):2562-2573
Site-specifically ¹¹C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death
Cheng Q; Lu L; Grafstrom J; Olofsson MH; Thorell J-O; Samen E; Johansson K; Ahlzen H-S; Linder S; Arner ESJ; Stone-Elander S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;430(1):90-94
Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells
Ekstrom L; Johansson M; Monostory K; Rundlof A-K; Arner ESJ; Bjorkhem-Bergman L
Article: ANTIOXIDANTS AND REDOX SIGNALING. 2012;17(10):1407-1416
Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury.
Locy ML; Rogers LK; Prigge JR; Schmidt EE; Arnér ESJ; Tipple TE
Article: BIOCHEMICAL JOURNAL. 2012;447(1):167-174
Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase
Peng X; Xu J; Arner ESJ
Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(9):1446-1453
HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled Sel-tagged affibody molecule.
Wållberg H; Grafström J; Cheng Q; Lu L; Martinsson Ahlzén H-S; Samén E; Thorell J-O; Johansson K; Dunås F; Olofsson MH; Stone-Elander S; Arnér ESJ; Ståhl S
Article: BIOCHEMICAL PHARMACOLOGY. 2012;83(6):815-820
Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase
Xu J; Arner ESJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2012;52(4):803-810
Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1
Prigge JR; Eriksson S; Iverson SV; Meade TA; Capecchi MR; Arner ESJ; Schmidt EE
Article: PLOS ONE. 2012;7(1):e30528
Biochemical discrimination between selenium and sulfur 2: mechanistic investigation of the selenium specificity of human selenocysteine lyase.
Johansson A-L; Collins R; Arnér ESJ; Brzezinski P; Högbom M
Article: PLOS ONE. 2012;7(8):e42151
Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts.
Cheng Q; Lu L; Grafström J; Olofsson MH; Thorell J-O; Samén E; Johansson K; Ahlzén H-S; Stone-Elander S; Linder S; Arnér ESJ; Sel-tag Imaging Project
Article: PLOS ONE. 2012;7(1):e30581
Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase.
Collins R; Johansson A-L; Karlberg T; Markova N; van den Berg S; Olesen K; Hammarström M; Flores A; Schüler H; Schiavone LH; Brzezinski P; Arnér ESJ; Högbom M
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2011;51:S113
Thioredoxin Reductase Inhibition Induces Nrf2-mediated Antioxidant Responses in Murine Transformed Clara Cells
Locy ML; Rogers LK; Nelin LD; Prigge JR; Schmidt EE; Arner ESJ; Tipple TE
Conference publication: TOXICOLOGY LETTERS. 2011;205:S55
Chelating agents regenerate mammalian thioredoxin reductase inhibited by mercury: Comparison with selenite effects on treatment of mercury poisoning
Carvalho C; Lu J; Arner E; Holmgren A
Other: ANTIOXIDANTS AND REDOX SIGNALING. 2011;15(3):845-851
Redox Pioneer: Professor Arne Holmgren
Arner ESJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(9):1114-1123
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay
Prast-Nielsen S; Dexheimer TS; Schultz L; Stafford WC; Cheng Q; Xu J; Jadhav A; Arner ESJ; Simeonov A
Journal article: CHEMINFORM. 2011;42(17):no
ChemInform Abstract: Human Protein Atlas of Redox Systems — What Can Be Learnt?
Dammeyer P; Arner ESJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(6):689-699
Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors
Rackham O; Shearwood A-MJ; Thyer R; McNamara E; Davies SMK; Callus BA; Miranda-Vizuete A; Berners-Price SJ; Cheng Q; Arner ESJ; Filipovska A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(3):1064-1069
Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans
Stenvall J; Fierro-Gonzalez JC; Swoboda P; Saamarthy K; Cheng Q; Cacho-Valadez B; Arner ESJ; Persson OP; Miranda-Vizuete A; Tuck S
Book chapter: ENCYCLOPEDIA OF CANCER. 2011;p. 3670-3671
Thioredoxin System
Arnér ESJ; Holmgren A
Book chapter: SELENIUM. 2011;p. 1-19
History of Selenium Research
Arnér ESJ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1810(1):111-138
Human Protein Atlas of redox systems - What can be learnt?
Dammeyer P; Arner ESJ
Article: THE FASEB JOURNAL. 2011;25(1):370-381
Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning
Carvalho CML; Lu J; Zhang X; Arner ESJ; Holmgren A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2010;49(11):1765-1778
Noble metal targeting of thioredoxin reductase - covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin
Prast-Nielsen S; Cebula M; Pader I; Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(28):21708-21723
The Selenium-independent Inherent Pro-oxidant NADPH Oxidase Activity of Mammalian Thioredoxin Reductase and Its Selenium-dependent Direct Peroxidase Activities
Cheng Q; Antholine WE; Myers JM; Kalyanaraman B; Arner ESJ; Myers CR
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1296-1303
Selenoproteins-What unique properties can arise with selenocysteine in place of cysteine?
Arner ESJ
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2010;49:S98-S99
The Interactions of Thioredoxin Reductase with Quinones and Acrolein: Covalent Adducts and Stimulation of NADPH Oxidase Activity
Myers CR; Cheng Q; Myers JM; Antholine WE; Arner ESJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;47(11):1661-1671
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy
Eriksson SE; Prast-Nielsen S; Flaberg E; Szekely L; Arner ESJ
Article: CELL CYCLE. 2009;8(21):3584-3591
p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA
Hedstrom E; Eriksson S; Zawacka-Pankau J; Arner ESJ; Selivanova G
Editorial comment: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1790(11):1387-1388
Special issue on selenoprotein expression and function Preface
Lillig CH; Arner E
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2009;52(20):6474-6483
Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis
Rai G; Sayed AA; Lea WA; Luecke HF; Chakrapani H; Prast-Nielsen S; Jadhav A; Leister W; Shen M; Inglese J; Austin CP; Keefer L; Arner ESJ; Simeonov A; Maloney DJ; Williams DL; Thomas CJ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1793(10):1588-1596
The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia
Damdimopoulou PE; Miranda-Vizuete A; Arner ESJ; Gustafsson J-A; Damdimopoulos AE
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1790(6):495-526
Focus on mammalian thioredoxin reductases - Important selenoproteins with versatile functions
Arner ESJ
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2009;64(6):919-926
Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice
Thunberg S; Neimert-Andersson T; Cheng Q; Wermeling F; Bergstrom U; Swedin L; Dahlen S-E; Arner E; Scheynius A; Karlsson MCI; Gafvelin G; van Hage M; Gronlund H
Article: EXPERIMENTAL CELL RESEARCH. 2009;315(8):1360-1371
Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1
Wallenborg K; Vlachos P; Eriksson S; Huijbregts L; Arner ESJ; Joseph B; Hermanson O
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;46(7):893-904
Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1
Rengby O; Cheng Q; Vahter M; Jornvall H; Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(6):3998-4008
Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1
Cheng Q; Sandalova T; Lindqvist Y; Arner ESJ
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2009;101(1):37-47
Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity
Hellberg V; Wallin I; Eriksson S; Hernlund E; Jerremalm E; Berndtsson M; Eksborg S; Arner ESJ; Shoshan M; Ehrsson H; Laurell G
Book chapter: ENCYCLOPEDIA OF CANCER. 2009;p. 2954-2956
Thioredoxin System
Arnér ESJ; Holmgren A
Conference publication: CANCER RESEARCH. 2009;69
Evaluation of plain platinum, palladium and gold salts as inhibitors of mammalian thioredoxin reductase: Implications for clinically used drugs and the development of new anticancer agents
Prast-Nielsen S; Arner E
Conference publication: FREE RADICAL RESEARCH. 2009;43:63
Drug-specific responses to cytotoxic agents mediated by high levels of thioredoxin reductase 1 in human A549 cancer cells
Eriksson S; Prast-Nielsen S; Flaberg E; Szekely L; Arner E
Article: BIOCHEMICAL PHARMACOLOGY. 2008;76(9):1097-1109
The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation
Cox AG; Brown KK; Arner ESJ; Hampton MB
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2008;45(4):494-502
Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated
Brown KK; Eriksson SE; Arner ESJ; Hampton MB
Article: PLOS ONE. 2008;3(4):e1846
Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells
Anestal K; Prast-Nielsen S; Cenas N; Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(5):2814-2821
Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1
Dammeyer P; Damdimopoulos AE; Nordman T; Jimenez A; Miranda-Vizuete A; Arner ESJ
Journal article: PLOS MEDICINE. 2007;4(8):1418
Thioredoxin glutathione reductase from Schistosoma mansoni:: An essential parasite enzyme and a key drug target (vol 4, art no e206, 2007)
Kuntz AN; Davioud-Charvet E; Sayed AA; Califf LL; Dessolin J; Arner ESJ; Williams DL
Article: PLOS MEDICINE. 2007;4(6):e206-1086
Thioredoxin glutathione reductase from schistosoma mansoni:: An essential parasite enzyme and a key drug target
Kuntz AN; Davioud-Charvet E; Sayed AA; Califf LL; Dessolin J; Arner ESJ; Williams DL
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2007;459(2):178-188
Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney
Crosley LK; Meplan C; Nicol F; Rundlof AK; Arner ESJ; Hesketh JE; Arthur JR
Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2007;73(2):432-441
Titration and conditional knockdown of the prfB gene in Escherichia coli:: Effects on growth and overproduction of the recombinant mammalian selenoprotein thioredoxin reductase
Rengby O; Arner ESJ
Article: CHEMBIOCHEM. 2006;7(12):1976-1981
Selenolthiol and dithiol C-terminal tetrapeptide motifs for one-step purification and labeling of recombinant proteins produced in E. coli
Cheng Q; Johansson L; Thorell J-O; Fredriksson A; Samen E; Stone-Elander S; Arner ESJ
Editorial comment: SEMINARS IN CANCER BIOLOGY. 2006;16(6):419
The thioredoxin system in cancer -: iniroduction to a thematic volume of Seminars in Cancer Biology
Arner ESJ; Holmgren A
Review: SEMINARS IN CANCER BIOLOGY. 2006;16(6):420-426
The thioredoxin system in cancer
Arner ESJ; Holmgren A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2006;41(4):649-656
Studies of an active site mutant of the selenoprotein thioredoxin reductase:: The Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme
Johansson L; Arscott LD; Ballou DP; Williams CHJ; Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(9):5593-5603
Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells
Cenas N; Prast S; Nivinskas H; Sarlauskas J; Arnér ESJ
Conference publication: FREE RADICAL RESEARCH. 2006;40:S51
Selenium compromised thioredoxin reductase-derived apoptotic proteins (SecTRAPs): Potent killers of cancer cells
Arner ESJ
Book chapter: SELENIUM. 2006;p. 221-230
Biotechnology of selenocysteine
Johansson L; Arnér ESJ
Article: NATURE PROTOCOLS. 2006;1(2):604-613
Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with ¹¹C
Cheng Q; Stone-Elander S; Arner ESJ
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1726(1):1-13
Selenocysteine in proteins -: properties and biotechnological use
Johansson L; Gafvelin G; Arnér ESJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2005;39(5):696-703
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
Witte AB; Anestål K; Jerremalm E; Ehrsson H; Arnér ESJ
Journal article: AFCS-NATURE MOLECULE PAGES. 2005
Thioredoxin reductase 1
Arnér E
Article: THE FEBS JOURNAL. 2005;272(13):3449-3460
A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation
Johansson L; Svensson L; Bergström U; Jacobsson-Ekman G; Arnér ESJ; van Hage M; Bucht A; Gafvelin G
Conference publication: JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS. 2005;48:S38
EVALUATION OF NOVEL SELENOLTHIOL AND DITHIOL SEL-TAG VARIANTS FOR PURIFICATION AND ¹¹C-LABELING OF RECOMBINANT PROTEINS PRODUCED IN E. COLI
Cheng Q; Johansson L; Fredriksson A; Thorell J-O; Stone-Elander S; Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(52):54510-54517
Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells -: Effect on cell growth and differentiation
Nalvarte I; Damdimopoulos AE; Nystöm C; Nordman T; Miranda-Vizuete A; Olsson JM; Eriksson L; Björnstedt M; Arnér ESJ; Spyrou G
Article: NATURE METHODS. 2004;1(1):61-66
Exploiting the 21st amino acid -: purifying and labeling proteins by selenolate targeting
Johansson L; Chen CY; Thorell JO; Fredriksson A; Stone-Elander S; Gafvelin G; Arnér ESJ
Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2004;70(9):5159-5167
Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis
Rengby O; Johansson L; Carlson LA; Serini E; Vlamis-Gardikas A; Kårsnäs P; Arnér ESJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;321(1):94-101
Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli
Jiang ZH; Arnér ESJ; Mu Y; Johansson L; Shi JM; Zhao SQ; Liu SJ; Wang RY; Zhang TZ; Yan GL; Liu JQ; Shen JC; Luo GM
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2004;37(1):71-85
Thioredoxin reductase 1 is upregulated in atherosclerotic plaques:: Specific induction of the promoter in human macrophages by oxidized low-density lipoproteins
Furman C; Rundlöf AK; Larigauderie G; Jaye M; Bricca G; Copin C; Kandoussi AM; Fruchart JC; Arnér ESJ; Rouis M
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2004;36(5):641-656
Evidence for intriguingly complex transcription of human thioredoxin reductase 1
Rundlöf AK; Janard M; Miranda-Vizuete A; Arnér ESJ
Review: ANTIOXIDANTS AND REDOX SIGNALING. 2004;6(1):41-52
Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events
Rundlöf AK; Arnér ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(4):2583-2592
Interactions of quinones with thioredoxin reductase -: A challenge to the antioxidant role of the mammalian selenoprotein
Cenas N; Nivinskas H; Anusevicius Z; Sarlauskas J; Lederer F; Arnér ESJ
Conference publication: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2004;197(3):180
The major dust mite allergen Der p 2 is differentially distributed after intratracheal delivery in sensitised and non-sensitised mice
Svensson L; Johansson L; Arnér E; Bergström U; van Hage-Hamsten M; Bucht A; Gafvelin G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(22):12618-12623
Active sites of thioredoxin reductases:: Why selenoproteins?
Gromer S; Johansson L; Bauer H; Arscott LD; Rauch S; Ballou DP; Williams CH; Schirmer RH; Arnér ESJ
Book chapter: CELLULAR IMPLICATIONS OF REDOX SIGNALING. 2003;p. 27-45
Selenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox Signaling
Arnér ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(18):15966-15972
Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine
Anestål K; Arnér ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(4):2141-2146
The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone -: A novel mechanism for defense against oxidative stress
Xia L; Nordman T; Olsson JM; Damdimopoulos A; Björkhem-Bergman L; Nalvarte I; Eriksson LC; Arnér ESJ; Spyrou G; Björnstedt M
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2003;35:S124
Induction of apoptosis in cancer cells by selenium compromised thioredoxin reductase
Anestål K; Arnér E
Published conference paper: BIOFACTORS. 2003;18(1-4):45-50
Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase
Nordman T; Xia L; Björkhem-Bergman L; Damdimopoulos A; Nalvarte I; Arnér ESJ; Spyrou G; Eriksson LC; Björnstedt M; Olsson JM
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):291
The thioredoxin reductase/thioredoxin system is upregulated in atherosclerotic plaques:: Specific induction in human macrophages by oxidized low density lipoproteins
Furman C; Rundlöf AK; Jaye M; Searfoss G; Yue KT; Larigauderie G; Copin C; Kandoussi AM; Fruchart JC; Arnér ESJ; Rouis M
Book chapter: ENCYCLOPEDIA OF MOLECULAR BIOLOGY. 2002;p.
Glutaredoxin
Holmgren A; Arnér ESJ; Berndt KD
Book chapter: WILEY ENCYCLOPEDIA OF MOLECULAR MEDICINE. 2002;p.
Glutaredoxin
Holmgren A; Arnér ESJ; Berndt KD
Book chapter: WILEY ENCYCLOPEDIA OF MOLECULAR MEDICINE. 2002;p.
Thioredoxin
Arnér ESJ; Holmgren A
Book chapter: WILEY ENCYCLOPEDIA OF MOLECULAR MEDICINE. 2002;p.
Thioredoxin Reductase
Arnér ESJ; Holmgren A
Book chapter: ENCYCLOPEDIA OF MOLECULAR BIOLOGY. 2002;p.
Thioredoxin Reductase
Holmgren A; Arnér ESJ; Berndt KD
Book chapter: ENCYCLOPEDIA OF MOLECULAR BIOLOGY. 2002;p.
Thioredoxin
Holmgren A; Arnér ESJ; Berndt KD
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2002;33:S301
The mammalian thioredoxin system
Arnér ESJ
Review: METHODS IN ENZYMOLOGY. 2002;347:226-235
Recombinant expression of mammalian selenocysteine-containing thioredoxin reductase and other selenoproteins in Escherichia coli
Arnér ESJ
Review: FREE RADICAL BIOLOGY AND MEDICINE. 2001;31(11):1287-1312
Reactive oxygen species, antioxidants, and the mammalian thioredoxin system
Nordberg J; Arnér ESJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2001;31(10):1170-1178
Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex
Arnér ESJ; Nakamura H; Sasada T; Yodoi J; Holmgren A; Spyrou G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(32):30542-30551
The core promoter of human thioredoxin reductase 1
Rundlöf AK; Carlsten M; Arnér ESJ
Article: CURRENT PROTOCOLS IN TOXICOLOGY / EDITORIAL BOARD, MAHIN D. MAINES (EDITOR-IN-CHIEF) ... [ET AL.]. 2001;Chapter 7:Unit-7.4.
Measurement of thioredoxin and thioredoxin reductase.
Arnér ES; Holmgren A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(48):37474-37480
Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma
Pekkari K; Gurunath R; Arnér ESJ; Holmgren A
Review: THE FEBS JOURNAL. 2000;267(20):6102-6109
Physiological functions of thioredoxin and thioredoxin reductase
Arnér ESJ; Holmgren A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(11):5854-5859
Structure and mechanism of mammalian thioredoxin reductase:: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence
Zhong LW; Arnér ESJ; Holmgren A
Journal article: BIOCHEMICAL JOURNAL. 2000;347(3):661
Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region
RUNDLÖF A-K; CARLSTEN M; GIACOBINI MMJ; ARNÉR ESJ
Article: BIOCHEMICAL JOURNAL. 2000;347(Pt 3):661-668
Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′untranslated region
Rundlöf AK; Carlsten M; Giacobini MMJ; Arnér ESJ
Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;292(5):1003-1016
High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes
Arnér ESJ; Sarioglu H; Lottspeich F; Holmgren A; Böck A
Article: BIOFACTORS. 1999;10(2-3):219-226
Superoxide production by dinitrophenyl-derivatized thioredoxin reductase -: a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes
Arnér ESJ
Review: METHODS IN ENZYMOLOGY. 1999;300:226-239
Preparation and assay of mammalian thioredoxin and thioredoxin reductase
Arner ESJ; Zhong LW; Holmgren A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(18):10835-10842
Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue
Nordberg J; Zhong L; Holmgren A; Arnér ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(15):8581-8591
Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue
Zhon LW; Arnér ESJ; Ljung J; Åslund F; Holmgren A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;225(1):268-274
Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase
Arner ESJ; Nordberg J; Holmgren A
Review: LEUKEMIA AND LYMPHOMA. 1996;21(3-4):225-231
On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment
Arner ESJ
Other: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(8):3479-3482
1-CHLORO-2,4-DINITROBENZENE IS AN IRREVERSIBLE INHIBITOR OF HUMAN THIOREDOXIN REDUCTASE - LOSS OF THIOREDOXIN DISULFIDE REDUCTASE-ACTIVITY IS ACCOMPANIED BY A LARGE INCREASE IN NADPH OXIDASE ACTIVITY
ARNER ESJ; BJORNSTEDT M; HOLMGREN A
Article: EUROPEAN JOURNAL OF CANCER. 1995;31A(2):202-208
EXPRESSION OF DEOXYCYTIDINE KINASE AND PHOSPHORYLATION OF 2-CHLORODEOXYADENOSINE IN HUMAN NORMAL AND TUMOR-CELLS AND TISSUES
SPASOKOUKOTSKAJA T; ARNER ESJ; BROSJO O; GUNVEN P; JULIUSSON G; LILIEMARK J; ERIKSSON S
Review: PHARMACOLOGY AND THERAPEUTICS. 1995;67(2):155-186
MAMMALIAN DEOXYRIBONUCLEOSIDE KINASES
ARNER ESJ; ERIKSSON S
Journal article: BRITISH JOURNAL OF HAEMATOLOGY. 1994;87(4):715-718
PHOSPHORYLATION OF 2-CHLORODEOXYADENOSINE (CDA) IN EXTRACTS OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF LEUKEMIC PATIENTS
ARNER ESI; SPASOKOUKOTSKAJA T; JULIUSSON G; LILIEMARK J; ERIKSSON S
Journal article: ADVANCES IN ENZYME REGULATION. 1994;34:13-25
PROPERTIES AND LEVELS OF DEOXYNUCLEOSIDE KINASES IN NORMAL AND TUMOR-CELLS - IMPLICATIONS FOR CHEMOTHERAPY
ERIKSSON S; ARNER E; SPASOKOUKOTSKAJA T; WANG LY; KARLSSON A; BROSJO O; GUNVEN P; JULUSSON G; LILIEMARK J
Book chapter: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1994;p. 201-204
Mitochondrial versus cytosolic activities of deoxyribonucleoside salvage enzymes.
Söderlund JC; Arnér ES
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1993;197(3):1499-1504
DEOXYCYTIDINE AND 2',3'-DIDEOXYCYTIDINE METABOLISM IN HUMAN MONOCYTE-DERIVED MACROPHAGES A STUDY OF BOTH ANABOLIC AND CATABOLIC PATHWAYS
ARNER ESJ; ERIKSSON S
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1993;268(30):22847-22852
SUBSTRATE-SPECIFICITY OF MITOCHONDRIAL 2'-DEOXYGUANOSINE KINASE - EFFICIENT PHOSPHORYLATION OF 2-CHLORODEOXYADENOSINE
WANG LY; KARLSSON A; ARNER ESJ; ERIKSSON S
Journal article: INTERNATIONAL JOURNAL OF CLINICAL PHARMACY. 1993;15(Suppl 4):f15-f30
Abstracts of poster presentations
Agostinho AB; Rosi F; Tabucchi A; Carlucci F; Pizzichini M; Arnér ESJ; Eriksson S; Barankiewicz J; Trembacz H; Zwierzchowski L; Bergman AM; van Haperen VWTR; Veerman G; Vermorken JB; Peters GJ; Bory C; Chantin C; Rocca JL; Bzowska A; Ananlev AV; Ramzaeva N; Alksins E; Maurins JA; Kulikowska E; Shugar D; Davies PM; Fairbanks LD; Simmonds HA; De Graaf TW; Van Dijk W; de Jong D; Huysmans F; De Abreu R; Monnens L; Dijkman H; van Liebergen F; Assmann K; Duley JA; Hanefeld F; Fabianowska-Majewska K; Duley AJ; Greger J; Wasiak T; Gathof BS; Ried T; Zwieauer K; Gresser U; Griesmacher A; Weigel G; Müller MM; Gross M; Empl W; Guisan B; Roch-Ramel F; Harley EH; Baumgarten I; Kaletha K; Nagel-Starczynowska G; Karlsson A; Lambooy L; Boerbooms A; De Abreu R; van de Putte L; Stolk J; vd Pulte L; Komissarov AA; Romanova DV; Debabov VG; Kozlov AM; Sokolov VB; Aksinenko AY; Fetisov VI; Komoriya K; Osada Y; Hasegawa M; Kondo S; Couch RC; Griffin TB; Lakaschus G; Löffler HG; Löffler M; Jiménez ML; Salinero MA; Guilarte JS; Matesanz JP; Medina LV; Galiana JR; Marlewski M; Smolenski RT; Swierczynski J; Rutkowski B; Zydowo MM; Micheli V; Pescaglini M; Sestini S; Jacomelli G; Magagnoli C; Pompucci G; Hayek G; Mimouni M; Boptemps F; Van den Berghe G; Miranda ME; Mateos FA; Herrero E; González A; Puig JG; Miscetti P; Minelli A; Proietti A; Moroni M; Mezzasoma I; Moro JF; Noam I; Cameron JS; McBride MB; Mathew CGP; Ogg CS; Puig JG; Miranda ME; Mateos FA; Luzi L; Noordhuis P; Kazemier K; Kaspers GJL; Overgaard-Hansen K; Marcussen M; Klenow H; Pelatti A; Quaratino CP; D'Amario C; Tentarelli R; Giacomello A; Rocchigiani M; Iacomelli G; Pandolfi ML; Arezzini L; Terzuoli L; Pagani R; Di Sciascio N; Colosimo A; Ranieri-Paggi M; Ronca F; Brown PE; Moir AJG; Raggi A; Schwendel A; Grune T; Siems WG; Holzhuetter HG; Sebesta I; Krijt J; Vondrak K; Kmoch S; Hrebicek M; Senatore G; Del Lucchese G; Martini C; Lucacchini A; Siems WG; Mertsch K; Blasig I; Grune T; Skladanowski AC; Hoffmann CS; Krass JD; Makarewicz W; Jastorff B; Slingerland RJ; Bodlaender JM; Van Lenthe H; Elzinga L; Van Kuilenburg ABP; Voûte PA; Van Gennip AH; Smid K; van der Wilt CL; Aherne GW; Pinedo HM; Sorqi ML; Rucci C; Zoppini A; Staub M; Sasvári-Székely M; Spasokukockaja T; Hrabák A; Stolk JN; De Abreu RA; De Koning DGM; Lambooy LHM; Kerstens PJSM; Boerbooms AMT; van de Putte LBA; Szüts P; Szirovicza É; åbrahám CS; Havass Z; Jezewska MM; Van Acker KJ; Eyskens FJ; Verkerk RH; Scharpé SS; van Kuppevelt TH; Veerkamp JH; Sabina RL; Van Laar JAM; Mayhew E; Durrani FA; Peters GJ; Rustum YM; Wang JZ; Leoncini R; Vannoni D; Marinello E
Journal article: ANALYTICAL BIOCHEMISTRY. 1993;210(1):102-105
CATABOLISM OF DEOXYCYTIDINE IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS AND ITS INTERFERENCE WITH THE DETERMINATION OF INSITU THYMIDYLATE SYNTHASE ACTIVITY
ARNER ESJ; ERIKSSON S
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1992;188(2):712-718
SELECTIVE ASSAYS FOR THYMIDINE KINASE-1 AND KINASE-2 AND DEOXYCYTIDINE KINASE AND THEIR ACTIVITIES IN EXTRACTS FROM HUMAN-CELLS AND TISSUES
ARNER ESJ; SPASOKOUKOTSKAJA T; ERIKSSON S
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1992;267(16):10968-10975
THYMIDINE AND 3'-AZIDO-3'-DEOXYTHYMIDINE METABOLISM IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES AND MONOCYTE-DERIVED MACROPHAGES - A STUDY OF BOTH ANABOLIC AND CATABOLIC PATHWAYS
ARNER ESJ; VALENTIN A; ERIKSSON S
Journal article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1991;309B:239-243
Expression and substrate specificities of human thymidine kinase 1, thymidine kinase 2 and deoxycytidine kinase.
Eriksson S; Munch-Petersen B; Kierdaszuk B; Arnér E
Journal article: EXPERIMENTAL CELL RESEARCH. 1988;178(2):335-342
DEOXYCYTIDINE KINASE IS CONSTITUTIVELY EXPRESSED IN HUMAN-LYMPHOCYTES - CONSEQUENCES FOR COMPARTMENTATION EFFECTS, UNSCHEDULED DNA-SYNTHESIS, AND VIRAL REPLICATION IN RESTING CELLS
ARNER ESJ; FLYGAR M; BOHMAN C; WALLSTROM B; ERIKSSON S
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1984;774(1):26-34
MAXIMAL FLUX RESPONSES AFTER MULTIPLE CHALLENGES WITH VASOPRESSIN
RUBIN MS; KING CF; WEISSMAN JD; GERSHATOR D; ARNER E; MASUR SK
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