Elias Arnérs forskargrupp

Publikationer

Alla gruppmedlemmars publikationer

• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2025;239:230-241

  Patient-derived TXNIP-deficient primary cells exhibit NRF2 activation linked to upregulation of glyoxalase 1 (GLO1)

  Maimaiti S; Dagnell M; Coppo L; Arner ESJ
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2025;:S0891-5849(25)00985-2

  Development of novel analogs of the TRi-1 and TRi-2 selenoprotein thioredoxin reductase inhibitors with initial assessment of their cytotoxicity profiles.

  Jović M; Gencheva R; Scholzen KC; Cheng Q; Selaković Ž; Arnér ESJ; Opsenica IM
• Article: REDOX BIOLOGY. 2025;85:103741

  The inhibition of TXNRD1 by methylglyoxal impairs the intracellular control of Mycobacterium tuberculosis

  Li H; Liu R; Kathamuthu GR; Gencheva R; Gong Z; Scholz AT; Alzrigat M; Coppo L; Arner ESJ; Rottenberg ME
• Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2025;64(35):e202508911

  Bicyclic Selenenyl Sulfides with Tuned Bioreductive Step Rates Reveal Constraints for Probes Targeting Thioredoxin Reductase

  Zeisel L; Weissenhorn LD; Scholzen KC; Madabeni A; Orian L; Arner ESJ; Thorn-Seshold O
• Article: G3-GENES GENOMES GENETICS. 2025;15(8):jkaf102

  The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans

  Valenzuela-Villatoro M; Gomez-Orte E; Guerrero-Gomez D; Cheng Q; Zheleva A; Mora-Lorca JA; Petrovic D; O'Neil NJ; Ceron J; Hatakeyama A; Onami S; Ordonez-Luque A; Ayuso C; Askjaer P; Filipovic MR; Arner ESJ; Cabello J; Miranda-Vizuete A
• Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2025;1872(6):119967

  Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria

  Fiorani M; Buffi G; Bagherlou N; Canonico B; De Matteis R; Guidarelli A; Montanari M; Battistelli M; Papa S; Coppo L; Cerioni L; Spina A; Cantoni O
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2025;233:317-329

  Selenium supplementation protects cancer cells from the oxidative stress and cytotoxicity induced by the combination of ascorbate and menadione sodium bisulfite

  Gencheva R; Coppo L; Arner ESJ; Ren X
• Article: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. 2025;88:127624

  Cellular activity of the cytosolic selenoprotein thioredoxin reductase 1 (TXNRD1) is modulated by copper and zinc levels in the cell culture medium

  Scholzen KC; Arner ESJ
• Article: FEBS OPEN BIO. 2025;15(3):379-382

  Young, female and scientist: exploring barriers, challenges and opportunities

  Derosiers N; Bernaerts E; Braun JL; Pozo Garcia V; Gencheva R; Paredes Garcia A; Tsagakis I
• Preprint: CHEMRXIV. 2025

  Bicyclic selenenyl sulfides tune stepwise rates of thiol/selenol addition, resolution, and cyclisation, to reveal cellular constraints for bioreductive probes targeting mammalian thioredoxin reductase

  Zeisel L; Dessen-Weissenhorn L; Scholzen KC; Madabeni A; Orian L; Arnér ESJ; Thorn-Seshold O
• Preprint: CHEMRXIV. 2025

  Selective Arylation of Se vs. S by Gold Compounds: Consequences for GPx Inhibition and A375 Sensitivity

  Kanavos I; Nakahata D; Barrett M; Ferreira dos Santos A; Zubiria-Ulacia M; Pieslinger G; da Silva Teixeira AB; Rocha C; Eberle J; Lobinski R; Matxain J; Hall M; Friedmann Angeli JP; Arnér E; Ronga L; de Paiva R
• Preprint: BIORXIV. 2025

  The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans

  Valenzuela-Villatoro M; Guerrero-Gómez D; Gómez-Orte E; Cheng Q; Zheleva A; Mora-Lorca JA; Petrovic D; O’Neil NJ; Cerón J; Hatakeyama A; Onami S; Filipovic M; Arnér ESJ; Cabello J; Miranda-Vizuete A
• Review: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2024;12(12):e009409

  Reactive oxygen species: Janus-faced molecules in the era of modern cancer therapy

  O'Reilly A; Zhao W; Wickstrom S; Arner ESJ; Kiessling R
• Journal article: INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE. 2024;26:100564

  Evaluating the amoeba thioredoxin reductase selenoprotein as potential drug target for treatment of Acanthamoeba infections.

  Loufouma-Mbouaka A; Andor A; Leitsch D; Pérez-Serrano J; Arnér ESJ; Walochnik J; Martín-Pérez T
• Review: CURRENT OPINION IN CHEMICAL BIOLOGY. 2024;83:102522

  Endogenous electrophiles and peroxymonocarbonate can link tyrosine phosphorylation cascades with the cytosolic TXNRD1 selenoprotein and the KEAP1/NRF2 system

  Dagnell M; Arner ESJ
• Article: INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE. 2024;26:100564

  Evaluating the amoeba thioredoxin reductase selenoprotein as potential drug target for treatment of Acanthamoeba infections

  Loufouma-Mbouaka A; Andor A; Leitsch D; Perez-Serrano J; Arner ESJ; Walochnik J; Martin-Perez T
• Doctoral thesis: 2024

  Mechanisms of action of thioredoxin reductase inhibitors in the context of cancer

  Gencheva R
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2024;224:s30

  No Evidence of Thioredoxin-interacting Protein (TXNIP) Inhibiting Thioredoxin1 (Trx1)

  Maimaiti S; Coppo L; Dagnel M; Arner E
• Article: EMBO JOURNAL. 2024;43(13):2789-2812

  TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation

  Marti-Andres P; Finamor I; Torres-Cuevas I; Perez S; Rius-Perez S; Colino-Lage H; Guerrero-Gomez D; Morato E; Marina A; Michalska P; Leon R; Cheng Q; Juranyi EP; Borbenyi-Galambos K; Millan I; Nagy P; Miranda-Vizuete A; Schmidt EE; Martinez-Ruiz A; Arner ESJ; Sastre J
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2024;218:8

  BEYOND REDUCTION: UNVEILING TRP14'S DUAL ROLE IN CYSTEINE HOMEOSTASIS AND REDOX DYNAMICS

  Marti-Andres P; Finamor I; Torres I; Perez S; Rius-Perez S; Colino-Lage H; Guerrero-Gomez D; Morato E; Marina A; Michalska P; Leon R; Cheng Q; Petra Juranyi E; Borbenyi-Galambos K; Millan I; Nagy P; Miranda-Vizuete A; Schmidt EE; Martinez-Ruiz A; Arner ESJ; Sastre J
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2024;218:23

  SELENOCYSTEINE VARIANT OF HUMAN PEROXIREDOXIN 2 IS MORE ACTIVE THAN THE WILD TYPE ENZYME

  Andor A; Pato ZA; Mohanraj M; Biri-Kovacs B; Kolonics A; Cheng Q; Arner ESJ
• Article: SCIENTIFIC REPORTS. 2024;14(1):11850

  Unraveling the role of natriuretic peptide clearance receptor (NPR3) in glomerular diseases

  Dabaghie D; Charrin E; Tonelius P; Rosengren B; Korkut G; Granqvist AB; Lal M; Patrakka J
• Preprint: BIORXIV. 2024

  A distinctive tumor compartment in pancreatic lobules defined by nascent stroma and classical tumor cell phenotype

  Söderqvist S; Viljamaa A; Geyer N; Strell C; Hekmati N; Engstrand J; Sparrelid E; Salmén C; Heuchel R; Zacharouli A; Ghorbani P; Harrizi S; Hamidi Y; Khorosjutina O; Milanova S; Schmierer B; Bozóky B; Moro CF; Gerling M
• Article: GENOME BIOLOGY AND EVOLUTION. 2024;16(3):evae041

  Ancient Loss of Catalytic Selenocysteine Spurred Convergent Adaptation in a Mammalian Oxidoreductase

  Rees J; Sarangi G; Cheng Q; Floor M; Andres AM; Oliva Miguel B; Villa-Freixa J; Arner ESJ; Castellano S
• Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2024;146(8):5204-5214

  Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology

  Zeisel L; Felber JG; Scholzen KC; Schmitt C; Wiegand AJ; Komissarov L; Arner ESJ; Thorn-Seshold O
• Journal article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2024;136(3)

  Ultralight Ultrafast Enzymes**

  Zhang X; Meng Z; Beusch CM; Gharibi H; Cheng Q; Lyu H; Di Stefano L; Wang J; Saei AA; Végvári Á; Gaetani M; Zubarev RA
• Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2024;63(3):e202316488

  Ultralight Ultrafast Enzymes

  Zhang X; Meng Z; Beusch CM; Gharibi H; Cheng Q; Lyu H; Di Stefano L; Wang J; Saei AA; Vegvari A; Gaetani M; Zubarev RA
• Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2024;326(1):H166-H179

  Ischemia-reperfusion myocardial infarction induces remodeling of left cardiac-projecting stellate ganglia neurons

  Barrett MS; Bauer TC; Li M-H; Hegarty DM; Mota CMD; Amaefuna CJ; Ingram SL; Habecker BA; Aicher SA
• Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2024;162:1-44

  Unresolved questions regarding cellular cysteine sources and their possible relationships to ferroptosis.

  Arnér ESJ; Schmidt EE
• Article: REDOX BIOCHEM CHEM. 2023;5-6:100015

  Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children.

  Cheff DM; Skröder H; Akhtar E; Cheng Q; Hall MD; Raqib R; Kippler M; Vahter M; Arnér ESJ
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;208:s118-s119

  Beware of the kat among the proteins

  Coppo L; Scholz A; Nolan E; Hernandez M; Wang X; Mishra P; Schnell R; Izumi A; Cheng Y; Dagnel M; Cheng Q; Arner E
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;208:s102-s103

  The anticancer compounds auranofin, TRi-1 and TRi-2 have distinct cytotoxicity profiles with regards to thioredoxin reductase inhibition

  Gencheva R; Cheng Q; Arner E
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;208:s10

  Selenium in control of cell death - unresolved questions regarding the potential roles of glutathione peroxidases and thioredoxin reductases

  Arner E
• Article: REDOX BIOLOGY. 2023;67:102915

  Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells

  Blandino G; Fiorani M; Canonico B; De Matteis R; Guidarelli A; Montanari M; Buffi G; Coppo L; Arner ESJ; Cantoni O
• Article: REDOX BIOLOGY. 2023;67:102897

  TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone

  Andor A; Mohanraj M; Pato ZA; Uri K; Biri-Kovacs B; Cheng Q; Arner ESJ
• Preprint: CHEMRXIV. 2023

  Piperazine-fused cyclic disulfides: high-performance bioreduction-activated cores for bifunctional probes and reagents

  Zeisel L; Felber JG; Scholzen KC; Schmitt C; Wiegand AJ; Komissarov L; Arnér ESJ; Thorn-Seshold O
• Article: JCI INSIGHT. 2023;8(17):e167656

  Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations

  Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
• Article: REDOX BIOLOGY. 2023;64:102806

  Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant

  Roveri A; Di Giacinto F; Rossetto M; Cozza G; Cheng Q; Miotto G; Zennaro L; Paolo MLD; Arner ESJ; De Spirito M; Maiorino M; Ursini F
• Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S50

  Probing Toxic Metals and Metalloids in Redox Biology using Synchrotron X-rays

  George G; Pickering I; Rengifo EM; Dolgova N; Cheng Q; Arner E
• Article: REDOX BIOLOGY. 2023;63:102719

  Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4

  Cheff DM; Cheng Q; Guo H; Travers J; Klumpp-Thomas C; Shen M; Arner ESJ; Hall MD
• Article: FRONTIERS IN MICROBIOLOGY. 2023;14:1198473

  Novel gold(III)-dithiocarbamate complex targeting bacterial thioredoxin reductase: antimicrobial activity, synergy, toxicity, and mechanistic insights

  Ratia C; Ballen V; Gabasa Y; Soengas RG; Velasco-de Andres M; Iglesias MJ; Cheng Q; Lozano F; Arner ESJ; Lopez-Ortiz F; Soto SM
• Article: REDOX BIOLOGY. 2023;62:102703

  The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

  Cheff DM; Huang C; Scholzen KC; Gencheva R; Ronzetti MH; Cheng Q; Hall MD; Arner ESJ
• Article: ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 2023;79(Pt 6):545-555

  Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans

  Mazurkewich S; Scholzen KC; Brusch RH; Poulsen J-CN; Theibich Y; Huttner S; Olsson L; Larsbrink J; Lo Leggio L
• Article: ANTIOXIDANTS. 2023;12(6):1180

  Disruption of Bacterial Thiol-Dependent Redox Homeostasis by Magnolol and Honokiol as an Antibacterial Strategy

  Ouyang Y; Tang X; Zhao Y; Zuo X; Ren X; Wang J; Zou L; Lu J
• Doctoral thesis: 2023

  Targeting glutathione peroxidases : identifying environmental modulators, and screening for novel small molecule inhibitors

  Cheff D
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2023;201:39

  THE ANTICANCER COMPOUNDS AURANOFIN, TRI-1 AND TRI-2 HAVE DISTINCT CYTOTOXICITY PROFILES WITH REGARDS TO THIOREDOXIN REDUCTASE INHIBITION

  Gencheva R; Cheng Q; Arner E
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2023;201:15

  TRP14 IS THE CELLULAR CYSTINE REDUCTASE AND ALSO REDUCES CYSTEINYLATED PROTEINS

  Marti-Andres P; Isabela; Perez S; Rius-Perez S; Torres-Cuevas I; Colino-Lage H; Guerrero-Gomez D; Morato E; Marina A; Michalska P; Leon R; Cheng Q; Miranda-Vizuete A; Schmidt EE; Martinez-Ruiz A; Arner ESJ; Sastre J
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2023;201:37-38

  IS THERE A SUBSTRATE SPECIFICITY OF GLUTATHIONE PEROXIDASE ISOFORMS?

  Schwarz M; Cheng Q; Loeser A; Arner ESJ; Kipp AP
• Review: ANTIOXIDANTS & REDOX SIGNALING. 2023;38(13):920-958

  Does Risk of Hyperhomocysteinemia Depend on Thiol-Disulfide Exchange Reactions of Albumin and Homocysteine?

  Coppo L; Scheggi S; DeMontis G; Priora R; Frosali S; Margaritis A; Summa D; Di Giuseppe D; Ulivelli M; Di Simplicio P
• Article: MOLECULAR THERAPY. 2023;31(3):825-846

  Photoreceptor laminin drives differentiation of human pluripotent stem cells to photoreceptor progenitors that partially restore retina function

  Tay HG; Andre H; Chrysostomou V; Adusumalli S; Guo J; Ren X; Tan WS; Tor JE; Moreno-Moral A; Plastino F; Bartuma H; Cai Z; Tun SBB; Barathi VA; Wei GTS; Grenci G; Chong LY; Holmgren A; Kvanta A; Guy CJ; Petretto E; Tryggvason K
• Doctoral thesis: 2023

  Identification of genes and pathways involved in the development and progression of glomerular diseases

  Dabaghie D
• Article: COMMUNICATIONS BIOLOGY. 2023;6(1):208

  Soluble Klotho protects against glomerular injury through regulation of ER stress response

  Charrin E; Dabaghie D; Sen I; Unnersjoe Jess D; Moller-Hackbarth K; Burmakin M; Mencke R; Zambrano S; Patrakka J; Olauson H
• Article: REDOX BIOLOGY. 2023;59:102593

  Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides

  Schwarz M; Loeser A; Cheng Q; Wichmann-Costaganna M; Schaedel P; Werz O; Arner ESJ; Kipp AP
• Preprint: CHEMRXIV. 2023

  Bifunctional, piperazine-fused cyclic disulfides for oxidoreductase-activated cellular proagents

  Zeisel L; Felber JG; Scholzen KC; Schmitt C; Wiegand AJ; Komissarov L; Arnér ESJ; Thorn-Seshold O
• Preprint: BIORXIV. 2023

  Ancient loss of catalytic selenocysteine spurred convergent adaptation in a mammalian oxidoreductase

  Rees J; Sarangi G; Cheng Q; Floor M; Andrés A; Miguel BO; Villà-Freixa J; Arnér ESJ; Castellano S
• Article: REDOX BIOLOGY. 2022;57:102510

  Modulating antioxidant systems as a therapeutic approach to retinal degeneration

  Ren X; Leveillard T
• Journal article: BIOMOLECULES. 2022;12(10):1504

  High-Resolution Ribosome Profiling Reveals Gene-Specific Details of UGA Re-Coding in Selenoprotein Biosynthesis

  Bohleber S; Fradejas-Villar N; Zhao W; Reuter U; Schweizer U
• Article: TRANSLATIONAL LUNG CANCER RESEARCH. 2022;11(10):2064-2078

  Plasma RNA profiling unveils transcriptional signatures associated with resistance to osimertinib in EGFR T790M positive non-small cell lung cancer patients

  Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
• Conference publication: DIABETOLOGIA. 2022;65(SUPPL 1):S389-S390

  Therapeutic blocking of NPRC, a podocyte - expressed target, is kidney protective in diabetic nephropathy

  Dabaghie D; Charrin E; Lal M; Patrakka J
• Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2022;17(9):S156

  Plasma Profiling Unveils Transcriptional Signatures Associated with Resistance to Osimertinib in Non-Small Cell Lung Cancer

  Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
• Journal article: JOURNAL OF THORACIC ONCOLOGY. 2022;17(9):s156

  P2.13-03 Plasma Profiling Unveils Transcriptional Signatures Associated with Resistance to Osimertinib in Non-Small Cell Lung Cancer

  Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
• Review: FREE RADICAL BIOLOGY AND MEDICINE. 2022;190:320-338

  Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases

  Gencheva R; Cheng Q; Arner ESJ
• Article: ANTIOXIDANTS. 2022;11(9):1643

  Mitochondrial Glrx2 Knockout Augments Acetaminophen-Induced Hepatotoxicity in Mice

  Li J; Tang X; Wen X; Ren X; Zhang H; Du Y; Lu J
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2022;189:32-33

  A mechanistic dissection of HyPer7, an ultrasensitive pH-independent biosensor

  Daria E; Ekaterina B; Gerardo F-S; Qing C; Elias A; Joris M
• Article: TOXICS. 2022;10(8):433

  N-Acetylcysteine or Sodium Selenite Prevent the p38-Mediated Production of Proinflammatory Cytokines by Microglia during Exposure to Mercury (II)

  Branco V; Coppo L; Aschner M; Carvalho C
• Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2022;722:109212

  The optimized quantum dot mediated thermometry reveals isoform specific differences in efficiency of myosin extracted from muscle mini bundles

  Li M; Coppo L; Jena BP; Larsson L
• Article: SCIENCE ADVANCES. 2022;8(23):eabn7063

  Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks

  Jeppsson K; Sakata T; Nakato R; Milanova S; Shirahige K; Bjorkegren C
• Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022;63(7)

  The potential role of rod-derived cone viability factor long (RdCVFL) in treating retinitis pigmentosa as a thioredoxin-like protein

  Ren X; Holmgren A; Arner ESJ; Leveillard TD
• Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(6):e004458

  Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress

  Renken S; Nakajima T; Magalhaes I; Mattsson J; Lundqvist A; Arner ESJ; Kiessling R; Wickstrom SL
• Article: ELIFE. 2022;11:e74549

  Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

  James J; Chen Y; Hernandez CM; Forster F; Dagnell M; Cheng Q; Saei AA; Gharibi H; Lahore GF; astrand A; Malhotra R; Malissen B; Zubarev RA; Arner ESJ; Holmdahl R
• Article: CHEM. 2022;8(5):1493-1517

  Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe

  Zeisel L; Felber JG; Scholzen KC; Poczka L; Cheff D; Maier MS; Cheng Q; Shen M; Hall MD; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O
• Article: TRANSLATIONAL LUNG CANCER RESEARCH. 2022;11(5):722-734

  Elevated expression of miR-494-3p is associated with resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer

  Kazmierczak D; Eide IJZ; Gencheva R; Lai Y; Lewensohn R; Tsakonas G; Grundberg O; de Petris L; McGowan M; Brustugun OT; Ekman S; Hydbring P
• Article: PHYSIOLOGICAL REPORTS. 2022;10(10):e15334

  Distinct morphology of cardiac- and brown adipose tissue-projecting neurons in the stellate ganglia of mice

  Barrett MS; Hegarty DM; Habecker BA; Aicher SA
• Article: REDOX BIOLOGY. 2022;51:102277

  Mitochondrial depletion of glutaredoxin 2 induces metabolic dysfunction-associated fatty liver disease in mice

  Scalcon V; Folda A; Lupo MG; Tonolo F; Pei N; Battisti I; Ferri N; Arrigoni G; Bindoli A; Holmgren A; Coppo L; Rigobello MP
• Review: ANTIOXIDANTS & REDOX SIGNALING. 2022;36(13):1037-1050

  Thiol-Based Antioxidants and the Epithelial/Mesenchymal Transition in Cancer

  Ogata FT; Simoes Sato AY; Coppo L; Arai RJ; Stern AI; Pequeno Monteiro H
• Article: REDOX BIOLOGY. 2022;51:102278

  Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus

  Fata F; Gencheva R; Cheng Q; Lullo R; Ardini M; Silvestri I; Gabriele F; Ippoliti R; Bulman CA; Sakanari JA; Williams DL; Arner ESJ; Angelucci F
• Article: NATURE COMMUNICATIONS. 2022;13(1):1754

  Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically

  Felber JG; Poczka L; Scholzen KC; Zeisel L; Maier MS; Busker S; Theisen U; Brandstaedter C; Becker K; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O
• Doctoral thesis: 2022

  Mechanisms behind Smc5/6 transcriptional regulation and cohesin-mediated chromosome organisation

  Milanova S
• Preprint: CHEMRXIV. 2022

  Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe

  Zeisel L; Felber JG; Poczka L; Scholzen K; Cheff D; Maier MS; Cheng Q; Shen M; Hall MD; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O
• Article: ANALYST. 2022;147(5):834-840

  A fluorescent probe for specifically measuring the overall thioredoxin and glutaredoxin reducing activity in bacterial cells

  Zuo X; Zhao Y; Zhao J; Ouyang Y; Qian W; Hou Y; Yu C; Ren X; Zou L; Fang J; Lu J
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2022;180:68

  Development of a chemical probe that selectively images the activity of mammalian Thioredoxin Reductase 1

  Zeisel L; Felber J; Poczka L; Scholzen K; Maier M; Cheng Q; Arner E; Thorn-Seshold J; Thorn-Seshold O
• Preprint: CHEMRXIV. 2022

  Cyclic 5-Membered Disulfides Are Not Selective Substrates of Thioredoxin Reductase, but Are Opened Nonspecifically

  Felber J; Poczka L; Scholzen K; Zeisel L; Maier MS; Busker S; Theisen U; Brandstädter C; Becker K; Arnér E; Ahlfeld J; Thorn-Seshold O
• Article: SCIENCE ADVANCES. 2022;8(1):eabm1148

  A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans

  Coppo L; Mishra P; Siefert N; Holmgren A; Paabo S; Zeberg H
• Preprint: BIORXIV. 2022

  The Emergence of the Metabolic Signaling of the Nucleoredoxin-like Genes during Evolution

  Aït-Ali N; Blond F; Clérin E; Morshedian A; Cesar Q; Delalande F; Koyanagi M; Birck C; Han J; Ren X; van Dorsselaer A; Terakita A; Fain GL; Léveillard T
• Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2022;62:177-196

  Thioredoxin Reductase Inhibition for Cancer Therapy

  Gencheva R; Arner ESJ
• Book chapter: REDOX CHEMISTRY AND BIOLOGY OF THIOLS. 2022;p. 197-218

  Chapter 10 Thioredoxin and glutathione reductases

  Arnér ESJ
• Article: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2022;662:95-118

  Expressing recombinant selenoproteins using redefinition of a single UAG codon in an RF1-depleted E. coli host strain.

  Cheng Q; Arnér ESJ
• Article: ANTIOXIDANTS. 2021;11(1):12

  Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis

  Aoun M; Cai X; Xu B; Lahore GF; Bonner MY; He Y; Backdahl L; Holmdahl R
• Preprint: RESEARCH SQUARE. 2021

  Ultralight ultrafast enzymes

  Zhang X; Meng Z; Beusch C; Gharibi H; Cheng Q; Stefano L; Wang J; Saei A; Vegvari A; Gaetani M; Zubarev R
• Preprint: BIORXIV. 2021

  Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation

  James J; Chen Y; Hernandez C; Forster F; Dagnell M; Cheng Q; Saei A; Gharibi H; Lahore GF; Åstrand A; Malhotra R; Malissen B; Zubarev R; Arnér ESJ; Holmdahl R
• Article: REDOX BIOLOGY. 2021;48:102184

  Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin

  Sabatier P; Beusch CM; Gencheva R; Cheng Q; Zubarev R; Arner ESJ
• Article: ECLINICALMEDICINE. 2021;42:101180

  Evaluation of dithiothreitol-oxidizing capacity (DOC) as a serum biomarker for chronic hepatitis B in patients exhibiting normal alanine aminotransferase levels: a pilot study towards better monitoring of disease

  Yang L; Zhang Y; Zhang K; Liu Z; He T; Zheng X; Li L; Arner ESJ; Zhang Z; Zhang J
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2021;177:s66

  TRP14 deficiency markedly reduces the inflammatory response in acute pancreatitis through Nrf2 activation

  Marti-Andres P; Perez S; Finamor I; Torres-Cuevas I; Rius-Perez S; Martinez-Ruiz A; Schmidt E; Arner ESJ; Sastre J
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2021;177:s128

  S-Adenosyl methionine administration enhances nitrosative stress in acute pancreatitis leading to blockade of the trans-sulfuration pathway and accumulation of homocysteine

  Rius-Perez S; Torres-Cuevas I; Perez S; Marti-Andres P; Talens R; Paradela A; Guerrero L; Franco L; Lopez-Rodas G; Torres L; Corrales F; Sastre J
• Journal article: REDOX BIOLOGY. 2021;48:102188

  Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4

  Fradejas-Villar N; Zhao W; Reuter U; Doengi M; Ingold I; Bohleber S; Conrad M; Schweizer U
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2021;177:s101

  Blockade of IL-6 abrogates pancreatic and lung damage caused by acute pancreatitis in PGC-1α knock-out mice

  Rius-Pérez S; Pérez S; Martí-Andrés P; Finamor I; Prieto I; García R; Monsalve M; Sastre J
• Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(21):11454

  The Effect of tRNA[Ser]Sec Isopentenylation on Selenoprotein Expression.

  Fradejas-Villar N; Bohleber S; Zhao W; Reuter U; Kotter A; Helm M; Knoll R; McFarland R; Taylor RW; Mo Y; Miyauchi K; Sakaguchi Y; Suzuki T; Schweizer U
• Review: ORPHANET JOURNAL OF RARE DISEASES. 2021;16(1):446

  Development of therapies for rare genetic disorders of GPX4: roadmap and opportunities

  Cheff DM; Muotri AR; Stockwell BR; Schmidt EE; Ran Q; Kartha RV; Johnson SC; Mittal P; Arner ESJ; Wigby KM; Hall MD; Ramesh SK
• Preprint: MEDRXIV. 2021

  Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

  Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
• Article: KIDNEY INTERNATIONAL. 2021;100(4):809-823

  Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor-κB signaling pathway

  Moller-Hackbarth K; Dabaghie D; Charrin E; Zambrano S; Genove G; Li X; Wernerson A; Lal M; Patrakka J
• Article: GEROSCIENCE. 2021;43(5):2289-2304

  Changes in the SARS-CoV-2 cellular receptor ACE2 levels in cardiovascular patients: a potential biomarker for the stratification of COVID-19 patients.

  Fagyas M; Bánhegyi V; Úri K; Enyedi A; Lizanecz E; Mányiné IS; Mártha L; Fülöp GÁ; Radovits T; Pólos M; Merkely B; Kovács Á; Szilvássy Z; Ungvári Z; Édes I; Csanádi Z; Boczán J; Takács I; Szabó G; Balla J; Balla G; Seferovic P; Papp Z; Tóth A
• Article: REDOX BIOLOGY. 2021;46:102070

  Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein

  Cheng Q; Roveri A; Cozza G; Bordin L; Rohn I; Schwerdtle T; Kipp A; Ursini F; Maiorino M; Miotto G; Arner ESJ
• Article: BRAIN STRUCTURE & FUNCTION. 2021;226(7):2387-2399

  Expression of type one cannabinoid receptor in different subpopulation of kisspeptin neurons and kisspeptin afferents to GnRH neurons in female mice.

  Wilheim T; Nagy K; Mohanraj M; Ziarniak K; Watanabe M; Sliwowska J; Kalló I
• Article: CELL HOST & MICROBE. 2021;29(8):1316-1332.e12

  Global mapping of Salmonella enterica-host protein-protein interactions during infection

  Walch P; Selkrig J; Knodler LA; Rettel M; Stein F; Fernandez K; Vieitez C; Potel CM; Scholzen K; Geyer M; Rottner K; Steele-Mortimer O; Savitski MM; Holden DW; Typas A
• Preprint: CHEMRXIV. 2021

  Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe

  Zeisel L; Felber JG; Poczka L; Scholzen K; Maier MS; Cheng Q; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O
• Preprint: CHEMRXIV. 2021

  Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe

  Zeisel L; Felber JG; Poczka L; Scholzen K; Maier MS; Cheng Q; Arnér ESJ; Thorn-Seshold J; Thorn-Seshold O
• Article: REDOX BIOLOGY. 2021;43:101975

  Glutaredoxin: Discovery, redox defense and much more

  Ogata FT; Branco V; Vale FF; Coppo L
• Article: JOURNAL OF ORGANOMETALLIC CHEMISTRY. 2021;943:121822

  Metallocenyl derivatives of ebselen are selective and competitive inhibitors of thioredoxin reductase

  Koh WX; Coppo L; Ganguly R; Holmgren A; Leong WK
• Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2021;143(23):8791-8803

  Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif

  Felber JG; Zeisel L; Poczka L; Scholzen K; Busker S; Maier MS; Theisen U; Brandstaedter C; Becker K; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O
• Article: ANTIOXIDANTS & REDOX SIGNALING. 2021;34(17):1355-1367

  Selenium Status in Diet Affects Acetaminophen-Induced HepatotoxicityviaInterruption of Redox Environment

  Li J; Cheng P; Li S; Zhao P; Han B; Ren X; Zhong JL; Lloyd MD; Pourzand C; Holmgren A; Lu J
• Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2021;2021:6621292

  Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases

  Hossain MF; Bodnar Y; Klein C; Salas CO; Arner ESJ; Gellert M; Lillig CH
• Journal article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2021;36(Supplement_1):gfab104.0021

  MO263KLOTHO IS PROTECTIVE IN THE CONTEXT OF ACUTE GLOMERULAR INJURY BUT IS NOT EXPRESSED IN PODOCYTES

  Charrin E; Dabaghie D; Mencke R; Sen I; Möller-Hackbarth K; Zambrano S; Olauson H; Patrakka J
• Other: REDOX BIOLOGY. 2021;41:101991

  In Memoriam Arne Holmgren (1940-2020)

  Arner ESJ
• Other: FREE RADICAL BIOLOGY AND MEDICINE. 2021;167:III-IV

  In Memoriam Arne Holmgren (1940-2020)

  Arner ESJ
• Conference publication: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2021;36

  KLOTHO IS PROTECTIVE IN THE CONTEXT OF ACUTE GLOMERULAR INJURY BUT IS NOT EXPRESSED IN PODOCYTES

  Charrin E; Dabaghie D; Mencke R; Sen I; Moller-Hackbarth K; Zambrano S; Olauson H; Patrakka J
• Editorial comment: SCIENCE ADVANCES. 2021;7(17):eabe7006

  Comment on "Evidence that the ProPerDP method is inadequate for protein persulfidation detection due to lack of specificity"

  Doka E; Arner ESJ; Schmidt EE; Dick TP; van der Vliet A; Yang J; Szatmari R; Ditroi T; Wallace JL; Cirino G; Olson K; Motohashi H; Fukuto JM; Pluth MD; Feelisch M; Akaike T; Wink DA; Ignarro LJ; Nagy P
• Article: JOURNAL OF MEDICINAL CHEMISTRY. 2021;64(8):4913-4946

  Discovery and Optimization of 2H-1λ²-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer

  Rohde JM; Karavadhi S; Pragani R; Liu L; Fang Y; Zhang W; McIver A; Zheng H; Liu Q; Davis MI; Urban DJ; Lee TD; Cheff DM; Hollingshead M; Henderson MJ; Martinez NJ; Brimacombe KR; Yasgar A; Zhao W; Klumpp-Thomas C; Michael S; Covey J; Moore WJ; Stott GM; Li Z; Simeonov A; Jadhav A; Frye S; Hall MD; Shen M; Wang X; Patnaik S; Boxer MB
• Article: NATURE COMMUNICATIONS. 2021;12(1):2141

  Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

  He B; Chen P; Zambrano S; Dabaghie D; Hu Y; Moller-Hackbarth K; Unnersjoe-Jess D; Korkut GG; Charrin E; Jeansson M; Bintanel-Morcillo M; Witasp A; Wennberg L; Wernerson A; Schermer B; Benzing T; Ernfors P; Betsholtz C; Lal M; Sandberg R; Patrakka J
• Preprint: PREPRINTS.ORG. 2021

  Development of Therapies for Rare Genetic Disorders of GPX4: Roadmap and Opportunities

  Cheff D; Muotri A; Stockwell B; Schmidt E; Ran Q; Kartha R; Johnson S; Mittal P; Arnér E; Wigby K; Hall M; Ramesh S
• Corrigendum: CHEMISTRYSELECT. 2021;6(12):2893

  S-Denitrosylation by the C-Terminal Swinging Arm of R1 Subunit: A Novel Mechanism to Restore Ribonucleotide Reductase Activity (vol 6, pg 1845, 2021)

  Sengupta R; Coppo L; Sircar E; Mishra P; Holmgren A
• Preprint: CHEMRXIV. 2021

  Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif

  Felber J; Zeisel L; Poczka L; Scholzen K; Busker S; Maier M; Theisen U; Brandstädter C; Becker K; Arnér E; Thorn-Seshold J; Thorn-Seshold O
• Preprint: CHEMRXIV. 2021

  Selective, Modular Probes for Thioredoxins Enabled by Rational Tuning of a Unique Disulfide Structure Motif

  Felber J; Zeisel L; Poczka L; Scholzen K; Busker S; Maier MS; Theisen U; Brandstädter C; Becker K; Arnér E; Thorn-Seshold J; Thorn-Seshold O
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2021;165:6-7

  The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth factor responses

  Arner E
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2021;165:5-6

  The selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1) as a main regulator of growth factor responses

  Arnér E
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2021;165:36

  Nitration of cystathionine β-synthase in acute pancreatitis

  Rius-Perez S; Perez S; Torres-Cuevas I; Marti-Andres P; Talens-Visconti R; Paradela A; Guerrero L; Franco L; Lopez-Rodas G; Torres L; Corrales F; Sastre J
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2021;165:36

  Obesity causes PGC-1α deficiency in exocrine pancreas leading to IL-6 upregulation via NF-κB in acute pancreatitis

  Rius-Pérez S; Pérez S; Martí-Andrés P; Finamor I; Prieto I; García R; Monsalve M; Sastre J
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51(3):682-693

  Genetic dissection of a major haplotype associated with arthritis reveal FcγR2b and FcγR3 to act additively

  Vaartjes D; Klaczkowska D; Cragg MS; Nandakumar KS; Backdahl L; Holmdahl R
• Article: ANTIOXIDANTS. 2021;10(3):359

  Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption

  Miller CG; Kundert JA; Prigge JR; Amato JA; Perez AE; Coppo L; Rizzo GN; Kavanaugh MP; Orlicky DJ; Shearn CT; Schmidt EE
• Preprint: RESEARCH SQUARE. 2021

  SIESTA as a universal unbiased proteomics approach for identification and prioritization of enzyme substrates 

  Saei AA; Beusch C; Sabatier P; Wells JA; Gharibi H; Meng Z; Chernobrovkin A; Rodin S; Näreoja K; Thorsell A-G; Karlberg T; Cheng Q; Lundström S; Gaetani M; Végvári Á; Arnér ESJ; Schüler H; Zubarev R
• Article: NATURE COMMUNICATIONS. 2021;12(1):1296

  System-wide identification and prioritization of enzyme substrates by thermal analysis

  Saei AA; Beusch CM; Sabatier P; Wells JA; Gharibi H; Meng Z; Chernobrovkin A; Rodin S; Nareoja K; Thorsell A-G; Karlberg T; Cheng Q; Lundstrom SL; Gaetani M; Vegvari A; Arner ESJ; Schuler H; Zubarev RA
• Article: CHEMISTRYSELECT. 2021;6(8):1845-1851

  S-Denitrosylation by the C-Terminal Swinging Arm of R1 Subunit: A Novel Mechanism to Restore Ribonucleotide Reductase Activity

  Sengupta R; Coppo L; Sircar E; Mishra P; Holmgren A
• Article: NATURE COMMUNICATIONS. 2021;12(1):610

  Endophilin A2 deficiency protects rodents from autoimmune arthritis by modulating T cell activation

  Norin U; Rintisch C; Meng L; Forster F; Ekman D; Tuncel J; Klocke K; Backlund J; Yang M; Bonner MY; Lahore GF; James J; Shchetynsky K; Bergquist M; Gjertsson I; Hubner N; Backdahl L; Holmdahl R
• Article: ANTIOXIDANTS. 2021;10(1):111

  Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H₂O₂ Together with Bicarbonate

  Dagnell M; Cheng Q; Arner ESJ
• Journal article: FRONTIERS IN NEUROSCIENCE. 2021;15:652099

  The Neurobiology of Selenium: Looking Back and to the Future.

  Schweizer U; Bohleber S; Zhao W; Fradejas-Villar N
• Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;264:289-309

  Effects of Mammalian Thioredoxin Reductase Inhibitors.

  Arnér ESJ
• Preprint: CHEMRXIV. 2020

  Cyclic 5-Membered Disulfides Are Not Selective Substrates of Thioredoxin Reductase, but Are Opened Nonspecifically by Thiols

  Felber J; Poczka L; Busker S; Theisen U; Zeisel L; Maier MS; Loy K; Brandstädter C; Scholzen K; Becker K; Arnér E; Ahlfeld J; Thorn-Seshold O
• Preprint: CHEMRXIV. 2020

  Cyclic 5-Membered Disulfides Are Not Selective Substrates of Thioredoxin Reductase, but Are Opened Nonspecifically by Thiols

  Felber J; Poczka L; Busker S; Theisen U; Zeisel L; Maier MS; Loy K; Brandstädter C; Scholzen K; Becker K; Arnér E; Ahlfeld J; Thorn-Seshold O
• Preprint: BIORXIV. 2020

  Transcription and replication organize cohesin-dependent chromosome loops

  Jeppsson K; Sakata T; Nakato R; Milanova S; Shirahige K; Björkegren C
• Article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(19):10984-11011

  Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

  Rai G; Urban DJ; Mott BT; Hu X; Yang S-M; Benavides GA; Johnson MS; Squadrito GL; Brimacombe KR; Lee TD; Cheff DM; Zhu H; Henderson MJ; Pohida K; Sulikowski GA; Dranow DM; Kabir M; Shah P; Padilha E; Tao D; Fang Y; Christov PP; Kim K; Jana S; Muttil P; Anderson T; Kunda NK; Hathaway HJ; Kusewitt DF; Oshima N; Cherukuri M; Davies DR; Norenberg JP; Sklar LA; Moore WJ; Dang CV; Stott GM; Neckers L; Flint AJ; Darley-Usmar VM; Simeonov A; Waterson AG; Jadhav A; Hall MD; Maloney DJ
• Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2020;33(9):2441-2445

  Inhibition of Thioredoxin Reductase by Triosmium Carbonyl Clusters

  Koh WX; Coppo L; Holmgren A; Kong JW; Leong WK
• Article: REDOX BIOLOGY. 2020;36:101646

  To inhibit TrxR1 is to inactivate STAT3-Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors

  Busker S; Page B; Arner ESJ
• Article: BREAST CANCER RESEARCH. 2020;22(1):80

  Identification and targeting of selective vulnerability rendered by tamoxifen resistance

  Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arner ESJ; Hartman J; Selivanova G
• Article: ANTIOXIDANTS & REDOX SIGNALING. 2020;33(3):145-165

  Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation

  Rius-Perez S; Perez S; Marti-Andres P; Monsalve M; Sastre J
• Article: GENOME RESEARCH. 2020;30(7):1060-1072

  Functional annotation of human long noncoding RNAs via molecular phenotyping

  Ramilowski JA; Yip CW; Agrawal S; Chang J-C; Ciani Y; Kulakovskiy IV; Mendez M; Ooi JLC; Ouyang JF; Parkinson N; Petri A; Roos L; Severin J; Yasuzawa K; Abugessaisa I; Akalin A; Antonov IV; Arner E; Bonetti A; Bono H; Borsari B; Brombacher F; Cameron CJF; Cannistraci CV; Cardenas R; Cardon M; Chang H; Dostie J; Ducoli L; Favorov A; Fort A; Garrido D; Gil N; Gimenez J; Guler R; Handoko L; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto K; Hayatsu N; Heutink P; Hirose T; Imada EL; Itoh M; Kaczkowski B; Kanhere A; Kawabata E; Kawaji H; Kawashima T; Kelly ST; Kojima M; Kondo N; Koseki H; Kouno T; Kratz A; Kurowska-Stolarska M; Kwon ATJ; Leek J; Lennartsson A; Lizio M; Lopez-Redondo F; Luginbuhl J; Maeda S; Makeev VJ; Marchionni L; Medvedeva YA; Minoda A; Mueller F; Munoz-Aguirre M; Murata M; Nishiyori H; Nitta KR; Noguchi S; Noro Y; Nurtdinov R; Okazaki Y; Orlando V; Paquette D; Parr CJC; Rackham OJL; Rizzu P; Martinez DFS; Sandelin A; Sanjana P; Semple CAM; Shibayama Y; Sivaraman DM; Suzuki T; Szumowski SC; Tagami M; Taylor MS; Terao C; Thodberg M; Thongjuea S; Tripathi V; Ulitsky I; Verardo R; Vorontsov IE; Yamamoto C; Young RS; Baillie JK; Forrest ARR; Guigo R; Hoffman MM; Hon CC; Kasukawa T; Kauppinen S; Kere J; Lenhard B; Schneider C; Suzuki H; Yagi K; de Hoon MJL; Shin JW; Carninci P
• Article: NEUROTHERAPEUTICS. 2020;17(3):1142-1152

  Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

  Carlstrom KE; Chinthakindi PK; Espinosa B; Al Nimer F; Arner ESJ; Arvidsson PI; Piehl F; Johansson K
• Article: PLOS GENETICS. 2020;16(6):e1008788

  Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease

  Backdahl L; Aoun M; Norin U; Holmdahl R
• Article: SLAS DISCOVERY. 2020;25(5):491-497

  Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences

  Roth JS; Lee TD; Cheff DM; Gosztyla ML; Asawa RR; Danchik C; Michael S; Simeonov A; Klumpp-Thomas C; Wilson KM; Hall MD
• Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2020;28(10):115422

  Predictive models for estimating cytotoxicity on the basis of chemical structures

  Sun H; Wang Y; Cheff DM; Hall MD; Shen M
• Article: REDOX BIOLOGY. 2020;32:101491

  Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin

  Saei AA; Gullberg H; Sabatier P; Beusch CM; Johansson K; Lundgren B; Arvidsson PI; Arner ESJ; Zubarev RA
• Article: BIOCHEMICAL PHARMACOLOGY. 2020;175:113873

  Inhibition of thioredoxin reductase 1 correlates with platinum-based chemotherapeutic induced tissue injury

  Cheng P; Liu H; Li Y; Pi P; Jiang Y; Zang S; Li X; Fu A; Ren X; Xu J; Holmgren A; Lu J
• Review: CURRENT MEDICINAL CHEMISTRY. 2020;27(12):1922-1939

  Targeting Bacterial Antioxidant Systems for Antibiotics Development

  Ren X; Zou L; Holmgren A
• Article: SCIENCE ADVANCES. 2020;6(12):eaax7945

  Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

  Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grander D; Arner ESJ; Tamm KP; Page BDG
• Article: ACS INFECTIOUS DISEASES. 2020;6(3):393-405

  Characterization of Lead Compounds Targeting the Selenoprotein Thioredoxin Glutathione Reductase for Treatment of Schistosomiasis

  Lyu H; Petukhov PA; Banta PR; Jadhav A; Lea WA; Cheng Q; Arner ESJ; Simeonov A; Thatcher GRJ; Angelucci F; Williams DL
• Article: INORGANIC CHEMISTRY. 2020;59(5):2711-2718

  Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase

  Pickering IJ; Cheng Q; Rengifo EM; Nehzati S; Dolgova NV; Kroll T; Sokaras D; George GN; Arner ESJ
• Review: ESSAYS IN BIOCHEMISTRY. 2020;64(1):45-53

  Common modifications of selenocysteine in selenoproteins

  Arner ESJ
• Article: FRONTIERS IN MICROBIOLOGY. 2020;10:3016

  Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase

  Dong C; Zhou J; Wang P; Li T; Zhao Y; Ren X; Lu J; Wang J; Holmgren A; Zou L
• Article: SCIENCE ADVANCES. 2020;6(1):eaax8358

  Control of protein function through oxidation and reduction of persulfidated states

  Doka E; Ida T; Dagnell M; Abiko Y; Luong NC; Balog N; Takata T; Espinosa B; Nishimura A; Cheng Q; Funato Y; Miki H; Fukuto JM; Prigge JR; Schmidt EE; Arner ESJ; Kumagai Y; Akaike T; Nagy P
• Book chapter: OXIDATIVE STRESS. 2020;p. 639-667

  Chapter 31 Perspectives of TrxR1-based cancer therapies

  Arnér ESJ
• Article: REDOX BIOLOGY. 2020;28:101335

  Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone

  Shu N; Cheng Q; Arner ESJ; Davies MJ
• Article: REDOX BIOLOGY. 2020;28:101324

  Blockade of the trans-sulfuration pathway in acute pancreatitis due to nitration of cystathionine β-synthase

  Rius-Perez S; Perez S; Torres-Cuevas I; Marti-Andres P; Talens-Visconti R; Paradela A; Guerrero L; Franco L; Lopez-Rodas G; Torres L; Corrales F; Sastre J
• Article: SLAS DISCOVERY. 2020;25(1):9-20

  Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

  Lee OW; Austin S; Gamma M; Cheff DM; Lee TD; Wilson KM; Johnson J; Travers J; Braisted JC; Guha R; Klumpp-Thomas C; Shen M; Hall MD
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2019;145:S21

  Targeting of the Selenoprotein Thioredoxin Reductase-1 by p-benzoquinone

  Shu N; Amer E; Cheng Q; Davies M
• Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):17501

  Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system (vol 9, 9841, 2019)

  Selvaraju K; Mofers A; Pellegrini P; Salomonsson J; Ahlner A; Morad V; Hillert E-K; Espinosa B; Arner ESJ; Jensen L; Malmstrom J; Turkina MV; D'Arcy P; Walters MA; Sunnerhagen M; Linder S
• Article: EXPERIMENTAL ANIMALS. 2019;68(4):435-442

  Neuron-specific Mafb knockout causes growth retardation accompanied by an impaired growth hormone/insulin-like growth factor I axis.

  Maimaiti S; Koshida R; Ojima M; Kulathunga K; Oishi H; Takahashi S
• Book chapter: SELENIUM RESEARCH FOR ENVIRONMENT AND HUMAN HEALTH: PERSPECTIVES, TECHNOLOGIES AND ADVANCEMENTS. 2019;p. 153-154

  New developments in recombinant selenoprotein production

  Cheng Q; Arnér ESJ
• Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(39):14185-14200

  Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations.

  Zhao W; Bohleber S; Schmidt H; Seeher S; Howard MT; Braun D; Arndt S; Reuter U; Wende H; Birchmeier C; Fradejas-Villar N; Schweizer U
• Article: ANTIOXIDANTS & REDOX SIGNALING. 2019;31(9):664-670

  Which Antioxidant System Shapes Intracellular H₂O₂ Gradients?

  Mishina NM; Bogdanova YA; Ermakova YG; Panova AS; Kotova DA; Bilan DS; Steinhorn B; Arner ES; Michel T; Belousov VV
• Article: MOLECULAR AND CELLULAR BIOLOGY. 2019;39(17):e00080-e00019

  MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition.

  Xiafukaiti G; Maimaiti S; Ogata K; Kuno A; Kudo T; Shawki HH; Oishi H; Takahashi S
• Article: METALLOMICS. 2019;11(9):1490-1497

  The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase

  Li J; Zuo X; Cheng P; Ren X; Sun S; Xu J; Holmgren A; Lu J
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(34):12708-12716

  Glutathione-glutaredoxin is an efficient electron donor system for mammalian p53R2-R1-dependent ribonucleotide reductase

  Sengupta R; Coppo L; Mishra P; Holmgren A
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(33):12330-12338

  Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades

  Dagnell M; Cheng Q; Rizvi SHM; Pace PE; Boivin B; Winterbourn CC; Arner ESJ
• Article: SCIENTIFIC REPORTS. 2019;9(1):9841

  Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system

  Selvaraju K; Mofers A; Pellegrini P; Salomonsson J; Ahlner A; Morad V; Hillert E-K; Espinosa B; Arner ESJ; Jensen L; Malmstrom J; Turkina MV; D'Arcy P; Walters MA; Sunnerhagen M; Linder S
• Article: FEBS LETTERS. 2019;593(14):1799-1806

  Characterization of mammalian glutaredoxin isoforms as S-denitrosylases

  Ren X; Sengupta R; Lu J; Lundberg JO; Holmgren A
• Article: BIOCHIMIE. 2019;162:46-54

  Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug

  Zhang X; Selvaraju K; Saei AA; D'Arcy P; Zubarev RA; Arner ESJ; Linder S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(23):11408-11417

  TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy

  McLoughlin MR; Orlicky DJ; Prigge JR; Krishna P; Talago EA; Cavigli IR; Eriksson S; Miller CG; Kundert JA; Sayin VI; Sabol RA; Heinemann J; Brandenberger LO; Iverson SV; Bothner B; Papagiannakopoulos T; Shearn CT; Arner ESJ; Schmidt EE
• Article: SCIENTIFIC REPORTS. 2019;9(1):5656

  Inhibition of the thioredoxin system by PX-12 (1-methylpropyl 2-imidazolyl disulfide) impedes HIV-1 infection in TZM-bl cells

  Lundberg M; Mattsson A; Reiser K; Holmgren A; Curbo S
• Article: DIABETES. 2019;68(4):709-723

  Absence of TXNIP in Humans Leads to Lactic Acidosis and Low Serum Methionine Linked to Deficient Respiration on Pyruvate

  Katsu-Jimenez Y; Vazquez-Calvo C; Maffezzini C; Halldin M; Peng X; Freyer C; Wredenberg A; Gimenez-Cassina A; Wedell A; Arner ESJ
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2019;134:350-358

  The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress

  Ren X; Santhosh SM; Coppo L; Ogata FT; Lu J; Holmgren A
• Article: ANALYTICAL BIOCHEMISTRY. 2019;568:24-30

  Enzymatic glutaredoxin-dependent method to determine glutathione and protein S-glutathionylation using fluorescent eosin-glutathione

  Coppo L; Ogata FT; Santhosh SM; Sventelius T; Holmgren A
• Review: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(4):544-553

  Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways

  Espinosa B; Arner ESJ
• Article: MOLECULAR NEUROBIOLOGY. 2019;56(2):1167-1187

  The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization.

  Mohanraj M; Sekar P; Liou H-H; Chang S-F; Lin W-W
• Article: BIOCHEMISTRY. 2019;58(3):166-170

  Rossmann-Fold Methyltransferases: Taking a "β-Turn" around Their Cofactor, S-Adenosylmethionine.

  Chouhan BPS; Maimaiti S; Gade M; Laurino P
• Article: METHODS IN MOLECULAR BIOLOGY. 2019;2007:51-77

  ProPerDP: A Protein Persulfide Detection Protocol.

  Dóka É; Arnér ESJ; Schmidt EE; Nagy P
• Article: INTERNATIONAL JOURNAL OF OBESITY. 2019;43(1):158-168

  Role of obesity in the release of extracellular nucleosomes in acute pancreatitis: a clinical and experimental study

  Perez S; Finamor I; Marti-Andres P; Pereda J; Campos A; Domingues R; Haj F; Sabater L; de-Madaria E; Sastre J
• Article: JOURNAL OF PATHOLOGY. 2019;247(1):48-59

  Obesity causes PGC-1α deficiency in the pancreas leading to marked IL-6 upregulation via NF-κB in acute pancreatitis

  Perez S; Rius-Perez S; Finamor I; Marti-Andres P; Prieto I; Garcia R; Monsalve M; Sastre J
• Article: ACS CENTRAL SCIENCE. 2018;4(12):1727-1741

  Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

  Kearney SE; Zahoránszky-Kőhalmi G; Brimacombe KR; Henderson MJ; Lynch C; Zhao T; Wan KK; Itkin Z; Dillon C; Shen M; Cheff DM; Lee TD; Bougie D; Cheng K; Coussens NP; Dorjsuren D; Eastman RT; Huang R; Iannotti MJ; Karavadhi S; Klumpp-Thomas C; Roth JS; Sakamuru S; Sun W; Titus SA; Yasgar A; Zhang Y-Q; Zhao J; Andrade RB; Brown MK; Burns NZ; Cha JK; Mevers EE; Clardy J; Clement JA; Crooks PA; Cuny GD; Ganor J; Moreno J; Morrill LA; Picazo E; Susick RB; Garg NK; Goess BC; Grossman RB; Hughes CC; Johnston JN; Joullie MM; Kinghorn AD; Kingston DGI; Krische MJ; Kwon O; Maimone TJ; Majumdar S; Maloney KN; Mohamed E; Murphy BT; Nagorny P; Olson DE; Overman LE; Brown LE; Snyder JK; Porco JA; Rivas F; Ross SA; Sarpong R; Sharma I; Shaw JT; Xu Z; Shen B; Shi W; Stephenson CRJ; Verano AL; Tan DS; Tang Y; Taylor RE; Thomson RJ; Vosburg DA; Wu J; Wuest WM; Zakarian A; Zhang Y; Ren T; Zuo Z; Inglese J; Michael S; Simeonov A; Zheng W; Shinn P; Jadhav A; Boxer MB; Hall MD; Xia M; Guha R; Rohde JM
• Article: CANCER CELL. 2018;34(6):922-938.e7

  Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling

  Iniguez AB; Alexe G; Wang EJ; Roti G; Pate S; Chen L; Kitara S; Conway A; Robichaud AL; Stolte B; Bandopadhayay P; Goodale A; Pantel S; Lee Y; Cheff DM; Hall MD; Guha R; Davis MI; Menard M; Nasholm N; Weiss WA; Qi J; Beroukhim R; Piccioni F; Johannessen C; Stegmaier K
• Published conference paper: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2018;1862(11):2511-2517

  Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase

  Gencheva R; Cheng Q; Arner ESJ
• Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;127:248-261

  NADPH-dependent and -independent disulfide reductase systems

  Miller CG; Holmgren A; Arner ESJ; Schmidt EE
• Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;127:238-247

  Selenocysteine in mammalian thioredoxin reductase and application of ebselen as a therapeutic

  Ren X; Zou L; Lu J; Holmgren A
• Editorial comment: FREE RADICAL BIOLOGY AND MEDICINE. 2018;127:1-2

  Selenium and selenoproteins in (redox) signaling, diseases, and animal models-200 year anniversary issue

  Brigelius-Flohe R; Arner ESJ
• Editorial comment: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2018;1862(11):2331-2332

  Selenium research in biochemistry and biophysics-200 year anniversary issue Preface

  Arner ESJ; Brigelius-Flohe R
• Corrigendum: JOURNAL OF MEDICINAL CHEMISTRY. 2018;61(19):8944

  Correction to A Drug of Such Damned Nature. Challenges and Opportunities in Translational Platinum Drug Research.

  Cheff DM; Hall MD
• Article: PHYTOMEDICINE. 2018;49:41-51

  Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway.

  Chio C-C; Tai Y-T; Mohanraj M; Liu S-H; Yang S-T; Chen R-M
• Preprint: BIORXIV. 2018

  System-wide identification and prioritization of enzyme substrates by thermal analysis (SIESTA)

  Saei AA; Beusch C; Sabatier P; Wells JA; Chernobrovkin A; Rodin S; Näreoja K; Thorsell A-G; Karlberg T; Cheng Q; Lundström S; Gaetani M; Végvári Á; Arnér ESJ; Schüler H; Zubarev R
• Article: NATURE COMMUNICATIONS. 2018;9(1):3785

  14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface

  Karlberg T; Hornyak P; Pinto AF; Milanova S; Ebrahimi M; Lindberg M; Pullen N; Nordstrom A; Loverli E; Caraballo R; Wong EV; Nareoja K; Thorsell A-G; Elofsson M; De la Cruz EM; Bjorkegren C; Schuler H
• Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;125:72-80

  Association of NOX2 subunits genetic variants with autoimmune diseases

  Zhong J; Olsson LM; Urbonaviciute V; Yang M; Backdahl L; Holmdahl R
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2018;293(35):13750-13765

  High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2.

  Coussens NP; Kales SC; Henderson MJ; Lee OW; Horiuchi KY; Wang Y; Chen Q; Kuznetsova E; Wu J; Chakka S; Cheff DM; Cheng KC-C; Shinn P; Brimacombe KR; Shen M; Simeonov A; Lal-Nag M; Ma H; Jadhav A; Hall MD
• Article: SCIENTIFIC REPORTS. 2018;8(1):12671

  Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

  Haffo L; Lu J; Bykov VJN; Martin SS; Ren X; Coppo L; Wiman KG; Holmgren A
• Article: ACS CHEMICAL BIOLOGY. 2018;13(8):2190-2202

  Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry

  Silvestri I; Lyu H; Fata F; Boumis G; Miele AE; Ardini M; Ippoliti R; Bellelli A; Jadhav A; Lea WA; Simeonov A; Cheng Q; Arner ESJ; Thatcher GRJ; Petukhov PA; Williams DL; Angelucci F
• Article: SCIENTIFIC REPORTS. 2018;8(1):11131

  Synergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production

  Zou L; Wang J; Gao Y; Ren X; Rottenberg ME; Lu J; Holmgren A
• Conference publication: FEBS OPEN BIO. 2018;8:58

  Selenoproteins as unique regulators of redox signaling pathways

  Arner ES
• Preprint: BIORXIV. 2018

  14-3-3 proteins activatePseudomonasexotoxins-S and –T by chaperoning a hydrophobic surface

  Karlberg T; Hornyak P; Filipa Pinto A; Milanova S; Ebrahimi M; Lindberg M; Püllen N; Nordström A; Löverli E; Caraballo R; Wong E; Näreoja K; Thorsell A-G; Elofsson M; De La Cruz E; Björkegren C; Schüler H
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S36

  Bicarbonate is required for hydrogen peroxide-dependent inactivation of PTP1B in presence of the Trx system and peroxiredoxin

  Dagnell M; Cheng Q; Pace PE; Hampton MB; Winterbourn CC; Arner ESJ
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S31

  Specific irreversible targeting of the selenoprotein thioredoxin reductase 1 in cancer therapy

  Arner ESJ
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S34

  Thioredoxin-related protein of 14 kDa may directly reduce protein cysteinylation motifs

  Marti-Andres P; Finamor I; Espinosa B; Perez S; Rius-Perez S; Talens-Visconti R; Leon R; Martinez-Ruiz A; Arner ESJ; Sastre J
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S46-S47

  Thioredoxin related protein of 14 kDa (TRP14, TXNDC17) represses Nrf2 and NFκB activities and augments HIF activation

  Fernandez BE; Pader I; Cebula M; Johansson K; Arner E
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:S46

  Screening for novel inhibitors of glutathione peroxidase

  Cheff DM; Cheng Q; Hall MD; Arner E
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:s153

  Chronic aspartame intake causes deficient glutathione synthesis and induces cxcll up-regulation in mice liver

  Finamor I; Perez S; Azzolin C; Rius S; Marti-Andres P; Sastre J; Amalia Pavanato M
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2018;120:s143

  Time-course of thiol oxidation of protein phosphatases during cerulein-induced acute pancreatitis

  Rius-Perez S; Perez S; Marti-Andres P; Finamor I; Talens-Visconti R; Cuadrado A; Toledano MB; Sastre J
• Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2018;26(8):1727-1739

  Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

  Rohde JM; Brimacombe KR; Liu L; Pacold ME; Yasgar A; Cheff DM; Lee TD; Rai G; Baljinnyam B; Li Z; Simeonov A; Hall MD; Shen M; Sabatini DM; Boxer MB
• Article: DRUG METABOLISM AND DISPOSITION. 2018;46(5):592-599

  Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity.

  Nieskens TTG; Peters JGP; Dabaghie D; Korte D; Jansen K; Van Asbeck AH; Tavraz NN; Friedrich T; Russel FGM; Masereeuw R; Wilmer MJ
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(428):eaaf7444

  Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

  Stafford WC; Peng X; Olofsson MH; Zhang X; Luci DK; Lu L; Cheng Q; Tresaugues L; Dexheimer TS; Coussens NP; Augsten M; Ahlzen H-SM; Orwar O; Ostman A; Stone-Elander S; Maloney DJ; Jadhav A; Simeonov A; Linder S; Arner ESJ
• Review: FREE RADICAL BIOLOGY AND MEDICINE. 2018;115:484-496

  The A to Z of modulated cell patterning by mammalian thioredoxin reductases

  Dagnell M; Schmidt EE; Arner ESJ
• Article: CELL. 2018;172(3):409-422.e21

  Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

  Ingold I; Berndt C; Schmitt S; Doll S; Poschmann G; Buday K; Roveri A; Peng X; Freitas FP; Seibt T; Mehr L; Aichler M; Walch A; Lamp D; Jastroch M; Miyamoto S; Wurst W; Ursini F; Amer ESJ; Fradejas-Villar N; Schweizer U; Zischka H; Angeli JPF; Conrad M
• Book chapter: OXIDATIVE FOLDING OF PROTEINS: CHEMICAL BIOLOGY. 2018;p. 355-378

  CHAPTER 4.4 Thioredoxin and Cellular Redox Systems: Beyond Protein Disulfide Bond Reduction

  Ren X; Lu J; Holmgren A
• Article: METHODS IN MOLECULAR BIOLOGY. 2018;1661:301-309

  Selective Evaluation of Thioredoxin Reductase Enzymatic Activities.

  Arnér ESJ
• Article: METHODS IN MOLECULAR BIOLOGY. 2018;1661:231-240

  Overexpression of Recombinant Selenoproteins in E. coli.

  Cheng Q; Arnér ESJ
• Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(22):9184-9204

  Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)

  Rai G; Brimacombe KR; Mott BT; Urban DJ; Hu X; Yang S-M; Lee TD; Cheff DM; Kouznetsova J; Benavides GA; Pohida K; Kuenstner EJ; Luci DK; Lukacs CM; Davies DR; Dranow DM; Zhu H; Sulikowski G; Moore WJ; Stott GM; Flint AJ; Hall MD; Darley-Usmar VM; Neckers LM; Dang CV; Waterson AG; Simeonov A; Jadhav A; Maloney DJ
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2017;112:24

  Selenium utilization by GPX4 was an evolutionary requirement to prevent hydroperoxide-induced ferroptosis

  Ingold I; Berndt C; Schmitt S; Doll S; Poschmann G; Roveri A; Peng X; Freitas FP; Aichler M; Jastroch M; Ursini F; Arner ESJ; Fradejas-Villar N; Schweizer U; Zischka H; Angeli JPF; Conrad M
• Review: ANTIOXIDANTS & REDOX SIGNALING. 2017;27(13):989-1010

  Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System

  Ren X; Zou L; Zhang X; Branco V; Wang J; Carvalho C; Holmgren A; Lu J
• Book chapter: HYDROGEN PEROXIDE METABOLISM IN HEALTH AND DISEASE. 2017;p. 387-402

  H 2 O 2 , Thioredoxin, and Signaling

  Arnér ESJ
• Article: SCIENTIFIC REPORTS. 2017;7(1):12758

  Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

  Urban DJ; Martinez NJ; Davis MI; Brimacombe KR; Cheff DM; Lee TD; Henderson MJ; Titus SA; Pragani R; Rohde JM; Liu L; Fang Y; Karavadhi S; Shah P; Lee OW; Wang A; McIver A; Zheng H; Wang X; Xu X; Jadhav A; Simeonov A; Shen M; Boxer MB; Hall MD
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(40):10737-10742

  Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK

  Jiang Y; Lin X; Tang Z; Lee C; Tian G; Du Y; Yin X; Ren X; Huang L; Ye Z; Chen W; Zhang F; Mi J; Gao Z; Wang S; Chen Q; Xing L; Wang B; Cao Y; Sessa WC; Ju R; Liu Y; Li X
• Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(10):1564-1569

  Abdominal subcutaneous adipose tissue cellularity in men and women

  Andersson DP; Arner E; Hogling DE; Ryden M; Arner P
• Article: EBIOMEDICINE. 2017;24:257-266

  Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes

  Qin X-Y; Hara M; Arner E; Kawaguchi Y; Inoue I; Tatsukawa H; Furutani Y; Nagatsuma K; Matsuura T; Wei F; Kikuchi J; Sone H; Daub C; Kawaji H; Lassmann T; Itoh M; Suzuki H; Carninci P; Hayashizaki Y; Kokudo N; Forrest ARR; Kojima S
• Article: REDOX BIOLOGY. 2017;13:278-287

  Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

  Branco V; Coppo L; Sola S; Lu J; Rodrigues CMP; Holmgren A; Carvalho C
• Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1239

  Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

  Diotallevi M; Checconi P; Palamara AT; Celestino I; Coppo L; Holmgren A; Abbas K; Peyrot F; Mengozzi M; Ghezzi P
• Article: NATURE BIOTECHNOLOGY. 2017;35(9):872-878

  An integrated expression atlas of miRNAs and their promoters in human and mouse

  de Rie D; Abugessaisa I; Alam T; Arner E; Arner P; Ashoor H; Astrom G; Babina M; Bertin N; Burroughs AM; Carlisle AJ; Daub CO; Detmar M; Deviatiiarov R; Fort A; Gebhard C; Goldowitz D; Guhl S; Ha TJ; Harshbarger J; Hasegawa A; Hashimoto K; Herlyn M; Heutink P; Hitchens KJ; Hon CC; Huang E; Ishizu Y; Kai C; Kasukawa T; Klinken P; Lassmann T; Lecellier C-H; Lee W; Lizio M; Makeev V; Mathelier A; Medvedeva YA; Mejhert N; Mungall CJ; Noma S; Ohshima M; Okada-Hatakeyama M; Persson H; Rizzu P; Roudnicky F; Saetrom P; Sato H; Severin J; Shin JW; Swoboda RK; Tarui H; Toyoda H; Vitting-Seerup K; Winteringham L; Yamaguchi Y; Yasuzawa K; Yoneda M; Yumoto N; Zabierowski S; Zhang PG; Wells CA; Summers KM; Kawaji H; Sandelin A; Rehli M; Hayashizaki Y; Carninci P; Forrest ARR; de Hoon MJL
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(35):14371-14380

  Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H₂O₂ exposure

  Dagnell M; Pace PE; Cheng Q; Frijhoff J; Ostman A; Arner ESJ; Hampton MB; Winterbourn CC
• Article: SCIENTIFIC DATA. 2017;4:170112

  Data Descriptor: FANTOM5 CAGE profiles of human and mouse samples

  Noguchi S; Arakawa T; Fukuda S; Furuno M; Hasegawa A; Hori F; Ishikawa-Kato S; Kaida K; Kaiho A; Kanamori-Katayama M; Kawashima T; Kojima M; Kubosaki A; Manabe R-I; Murata M; Nagao-Sato S; Nakazato K; Ninomiya N; Nishiyori-Sueki H; Noma S; Saijyo E; Saka A; Sakai M; Simon C; Suzuki N; Tagami M; Watanabe S; Yoshida S; Arner P; Axton RA; Babina M; Baillie JK; Barnett TC; Beckhouse AG; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Carlisle AJ; Clevers HC; Davis CA; Detmar M; Dohi T; Edge ASB; Edinger M; Ehrlund A; Ekwall K; Endoh M; Enomoto H; Eslami A; Fagiolini M; Fairbairn L; Farach-Carson MC; Faulkner GJ; Ferrai C; Fisher ME; Forrester LM; Fujita R; Furusawa J-I; Geijtenbeek TB; Gingeras T; Goldowitz D; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Hasegawa Y; Herlyn M; Heutink P; Hitchens KJ; Hume DA; Ikawa T; Ishizu Y; Kai C; Kawamoto H; Kawamura YI; Kempfle JS; Kenna TJ; Kere J; Khachigian LM; Kitamura T; Klein S; Klinken SP; Knox AJ; Kojima S; Koseki H; Koyasu S; Lee W; Lennartsson A; Mackay-sim A; Mejhert N; Mizuno Y; Morikawa H; Morimoto M; Moro K; Morris KJ; Motohashi H; Mummery CL; Nakachi Y; Nakahara F; Nakamura T; Nakamura Y; Nozaki T; Ogishima S; Ohkura N; Ohno H; Ohshima M; Okada-Hatakeyama M; Okazaki Y; Orlando V; Ovchinnikov DA; Passier R; Patrikakis M; Pombo A; Pradhan-Bhatt S; Qin X-Y; Rehli M; Rizzu P; Roy S; Sajantila A; Sakaguchi S; Sato H; Satoh H; Savvi S; Saxena A; Schmidl C; Schneider C; Schulze-Tanzil GG; Schwegmann A; Sheng G; Shin JW; Sugiyama D; Sugiyama T; Summers KM; Takahashi N; Takai J; Tanaka H; Tatsukawa H; Tomoiu A; Toyoda H; van de Wetering M; van den Berg LM; Verardo R; Vijayan D; Wells CA; Winteringham LN; Wolvetang E; Yamaguchi Y; Yamamoto M; Yanagi-Mizuochi C; Yoneda M; Yonekura Y; Zhang PG; Zucchelli S; Abugessaisa I; Arner E; Harshbarger J; Kondo A; Lassmann T; Lizio M; Sahin S; Sengstag T; Severin J; Shimoji H; Suzuki M; Suzuki H; Kawai J; Kondo N; Itoh M; Daub CO; Kasukawa T; Kawaji H; Carninci P; Forrest ARR; Hayashizaki Y
• Article: REDOX BIOLOGY. 2017;12:403-409

  Time- and cell-resolved dynamics of redox-sensitive Nrf2, HIF and NF-κB activities in 3D spheroids enriched for cancer stem cells

  Kipp AP; Deubel S; Arner ESJ; Johansson K
• Article: ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2017;51(15):8805-8814

  Cancer Risk Assessment of Airborne PAHs Based on in Vitro Mixture Potency Factors

  Dreij K; Mattsson A; Jarvis IWH; Lim H; Hurkmans J; Gustafsson J; Bergvall C; Westerholm R; Johansson C; Stenius U
• Article: EMBO MOLECULAR MEDICINE. 2017;9(8):1165-1178

  Synergistic antibacterial effect of silver and ebselen against multidrug-resistant Gram-negative bacterial infections

  Zou L; Lu J; Wang J; Ren X; Zhang L; Gao Y; Rottenberg ME; Holmgren A
• Article: REDOX BIOLOGY. 2017;12:634-647

  Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells

  Rodriguez-Garcia A; Hevia D; Mayo JC; Gonzalez-Menendez P; Coppo L; Lu J; Holmgren A; Sainz RM
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2017;108:S8-S9

  Molecular Mechanisms of Regulated Cell Pattering by the Mammalian Thioredoxin System

  Arner ES
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2017;108:s15

  Acute pancreatitis and cystinosis as experimental models of disulfide stress characterized by protein cysteinylation

  Finamor I; Perez S; Marti-Andres P; Gil A; Moreno M-L; Ruis-Perez S; Leon R; McBean G; Martinez-Ruiz A; Sastre J
• Article: CELL REPORTS. 2017;19(13):2771-2781

  Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase

  Prigge JR; Coppo L; Martin SS; Ogata F; Miller CG; Bruschwein MD; Orlicky DJ; Shearn CT; Kundert JA; Lytchier J; Herr AE; Mattsson A; Taylor MP; Gustafsson TN; Arner ESJ; Holmgren A; Schmidt EE
• Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(11):4517-4532

  A Drug of Such Damned Nature.¹ Challenges and Opportunities in Translational Platinum Drug Research

  Cheff DM; Hall MD
• Article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2017;1861(5):1177-1189

  Rutin protects against H₂O₂-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress

  Sthijns MMJPE; Schiffers PM; Janssen GM; Lemmens KJA; Ides B; Vangrieken P; Bouwman FG; Mariman EC; Pader I; Arner ESJ; Johansson K; Bast A; Haenen GRMM
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2017;106:270-277

  Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy

  Kudin AP; Baron G; Zsurka G; Hampel KG; Elger CE; Grote A; Weber Y; Lerche H; Thiele H; Nuernberg P; Schulz H; Ruppert A-K; Sander T; Cheng Q; Arner ESJ; Schomburg L; Seeher S; Fradejas-Villar N; Schweizer U; Kunz WS
• Corrigendum: CELL DEATH & DISEASE. 2017;8(4):e2751

  APR-246/PRIMA-1^MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase (vol 4, e881, 2013)

  Peng X; Zhang M-Q; Conserva F; Hosny G; Selivanova G; Bykov VJN; Arner ESJ; Wiman KG
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(13):5476-5487

  Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation

  Cheng Q; Arner ESJ
• Doctoral thesis: 2017

  Thioredoxin and glutaredoxin systems under oxidative and nitrosative stress

  Ren X
• Article: EMBO JOURNAL. 2017;36(5):693-702

  Cytosolic thioredoxin reductase 1 is required for correct disulfide formation in the ER

  Poet GJ; Oka OBV; van Lith M; Cao Z; Robinson PJ; Pringle MA; Arner ESJ; Bulleid NJ
• Article: ANTIOXIDANTS & REDOX SIGNALING. 2017;26(6):229-246

  Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution

  Johansson K; Cebula M; Rengby O; Dreij K; Carlstrom KE; Sigmundsson K; Piehl F; Arner ESJ
• Book chapter: ORGANOSELENIUM COMPOUNDS IN BIOLOGY AND MEDICINE. 2017;p. 303-316

  Chapter 11 Ebselen and Thioredoxin Systems in Human Health, Disease and Therapeutic Potential

  Lu J; Ren X; Zou L; Holmgren A
• Book chapter: ENCYCLOPEDIA OF CANCER. 2017;p. 4508-4511

  Thioredoxin System

  Arnér ESJ; Holmgren A
• Book chapter: SELENIUM IN PLANTS: PLANT ECOPHYSIOLOGY. 2017;p. 123-139

  Selenium Metabolism in Herbivores and Higher Trophic Levels Including Mammals

  Schomburg L; Arnér ESJ
• Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2017;136:139-151

  Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy

  Arner ESJ
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(46):24036-24040

  Selenoprotein Gene Nomenclature

  Gladyshev VN; Arner ES; Berry MJ; Brigelius-Flohe R; Bruford EA; Burk RF; Carlson BA; Castellano S; Chavatte L; Conrad M; Copeland PR; Diamond AM; Driscoll DM; Ferreiro A; Flohe L; Green FR; Guigo R; Handy DE; Hatfield DL; Hesketh J; Hoffmann PR; Holmgren A; Hondal RJ; Howard MT; Huang K; Kim H-Y; Kim IY; Koehrle J; Krol A; Kryukov GV; Lee BJ; Lee BC; Lei XG; Liu Q; Lescure A; Lobanov AV; Loscalzo J; Maiorino M; Mariotti M; Sandeep Prabhu K; Rayman MP; Rozovsky S; Salinas G; Schmidt EE; Schomburg L; Schweizer U; Simonovic M; Sunde RA; Tsuji PA; Tweedie S; Ursini F; Whanger PD; Zhang Y
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S47

  Thioredoxin Reductase 1 Directly Protects Protein Tyrosine Phosphatase 1B from Inactivation by H₂O₂

  Dagnell M; Pace P; Cheng Q; Frijhoff J; Ostman A; Arner E; Hampton M; Winterbourn C
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S6

  THIOREDOXIN REDUCTASE 1 (TrxR1) LINKS CELLULAR SIGNALING PATHWAYS CONTROLLING CELLULAR PHENOTYPE TO H₂O₂ MODULATION, NITROSYLATION, AND PERSULFIDATION PATHWAYS

  Arner ESJ
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;99:426-435

  Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms

  Zhang L; Cheng Q; Zhang L; Wang Y; Merrill GF; Ilani T; Fass D; Arner ESJ; Zhang J
• Article: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM. 2016;17(4):1470320316668435

  Circulating ACE2 activity correlates with cardiovascular disease development.

  Úri K; Fagyas M; Kertész A; Borbély A; Jenei C; Bene O; Csanádi Z; Paulus WJ; Édes I; Papp Z; Tóth A; Lizanecz E
• Conference publication: TOXICOLOGY LETTERS. 2016;258:S124-S125

  Rutin protects against endothelial dysfunction and induces nrf2-mediated adaptation in huvecs exposed to oxidative stress

  Sthijns M; Schiffers P; Janssen G; Lemmens K; Ides B; Vangrieken P; Bouwman F; Mariman E; Pader I; Arner E; Johansson K; Bast A; Haenen G
• Article: SCIENTIFIC REPORTS. 2016;6:33274

  Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors

  Miraglia E; Nylen F; Johansson K; Arner E; Cebula M; Farmand S; Ottosson H; Stromberg R; Gudmundsson GH; Agerberth B; Bergman P
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;97:375-385

  Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance

  Engelman R; Ziv T; Arner ESJ; Benhar M
• Article: EJNMMI RESEARCH. 2016;6(1):58

  Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake

  Cheng Q; Wallberg H; Grafstrom J; Lu L; Thorell J-O; Olofsson MH; Linder S; Johansson K; Tegnebratt T; Arner ESJ; Stone-Elander S; Ahlzen H-SM; Stahl S
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2016;96:s62

  γ-Glutamyl cysteine suppresses TNF-α up-regulation via protein phosphatases in acute pancreatitis

  Perez S; Finamor I; Rius-Perez S; Marti-Andres P; Talens R; Sastre J
• Article: ONCOTARGET. 2016;7(26):40233-40251

  Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads

  Kaminska KK; Bertrand HC; Tajima H; Stafford WC; Cheng Q; Chen W; Wells G; Arner ESJ; Chew E-H
• Article: SCIENTIFIC REPORTS. 2016;6:28080

  Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

  Peng X; Gimenez-Cassina A; Petrus P; Conrad M; Ryden M; Arner ESJ
• Article: MOLECULAR PHARMACEUTICS. 2016;13(6):2010-2025

  Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells

  van Gisbergen MW; Cebula M; Zhang J; Ottosson-Wadlund A; Dubois L; Lambin P; Tew KD; Townsend DM; Haenen GRMM; Drittij-Repders M-J; Saneyoshi H; Araki M; Shishido Y; Ito Y; Arner ESJ; Abe H; Morgenstern R; Johansson K
• Article: AMINO ACIDS. 2016;48(6):1477-1489

  Homocysteinemia control by cysteine in cerebral vascular patients after methionine loading test: evidences in physiological and pathological conditions in cerebro-vascular and multiple sclerosis patients

  Ulivelli M; Priora R; Di Giuseppe D; Coppo L; Summa D; Margaritis A; Frosali S; Bartalini S; Martini G; Cerase A; Di Simplicio P
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2016;94:110-120

  Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities

  Xu J; Cheng Q; Arner ESJ
• Article: ANALYTICAL BIOCHEMISTRY. 2016;499:24-33

  Determination of glutaredoxin enzyme activity and protein S-glutathionylation using fluorescent eosin-glutathione

  Coppo L; Montano SJ; Padilla AC; Holmgren A
• Article: FEMS YEAST RESEARCH. 2016;16(2):fow007

  PUFA-induced cell death is mediated by Yca1p-dependent and -independent pathways, and is reduced by vitamin C in yeast.

  Johansson M; Chen X; Milanova S; Santos C; Petranovic D
• Article: PLOS PATHOGENS. 2016;12(2):e1005442

  Nitric Oxide Protects against Infection-Induced Neuroinflammation by Preserving the Stability of the Blood-Brain Barrier

  Olivera GC; Ren X; Vodnala SK; Lu J; Coppo L; Leepiyasakulchai C; Holmgren A; Kristensson K; Rottenberg ME
• Book chapter: SELENIUM. 2016;p. 199-209

  Thioredoxin Reductase 1 as an Anticancer Drug Target

  Schmidt EE; Arnér ESJ
• Article: SCIENCE ADVANCES. 2016;2(1):e1500968

  A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

  Doka E; Pader I; Biro A; Johansson K; Cheng Q; Ballago K; Prigge JR; Pastor-Flores D; Dick TP; Schmidt EE; Arner ESJ; Nagy P
• Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):228-247

  Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation

  Holmdahl R; Sareila O; Olsson LM; Backdahl L; Wing K
• Review: PHYSIOLOGICAL REVIEWS. 2016;96(1):307-364

  PARADOXICAL ROLES OF ANTIOXIDANT ENZYMES: BASIC MECHANISMS AND HEALTH IMPLICATIONS

  Lei XG; Zhu J-H; Cheng W-H; Bao Y; Ho Y-S; Reddi AR; Holmgren A; Arner ESJ
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2015;89:192-200

  Oxidation of structural cysteine residues in thioredoxin 1 by aromatic arsenicals enhances cancer cell cytotoxicity caused by the inhibition of thioredoxin reductase 1

  Zhang X; Lu J; Ren X; Du Y; Zheng Y; Ioannou PV; Holmgren A
• Review: ANTIOXIDANTS & REDOX SIGNALING. 2015;23(10):823-853

  TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System

  Cebula M; Schmidt EE; Arner ESJ
• Article: ONCOTARGET. 2015;6(18):16488-16506

  Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells

  Sachweh MCC; Stafford WC; Drummond CJ; McCarthy AR; Higgins M; Campbell J; Brodin B; Arner ESJ; Lain S
• Article: JOURNAL OF CHEMICAL EDUCATION. 2015;92(5):903-906

  Simultaneous Determination of Pyridoxine and Riboflavin in Energy Drinks by High-Performance Liquid Chromatography with Fluorescence Detection

  Marti-Andres P; Escuder-Gilabert L; Martin-Biosca Y; Sagrado S; Medina-Hernandez MJ
• Article: ANTIOXIDANTS & REDOX SIGNALING. 2015;22(11):938-950

  Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis

  Hellfritsch J; Kirsch J; Schneider M; Fluege T; Wortmann M; Frijhoff J; Dagnell M; Fey T; Esposito I; Koelle P; Pogoda K; Angeli JPF; Ingold I; Kuhlencordt P; Ostman A; Pohl U; Conrad M; Beck H
• Article: NATURE COMMUNICATIONS. 2015;6:6479

  Dietary methionine can sustain cytosolic redox homeostasis in the mouse liver

  Eriksson S; Prigge JR; Talago EA; Arner ESJ; Schmidt EE
• Article: ENVIRONMENTAL SCIENCE & TECHNOLOGY. 2015;49(5):3101-3109

  Detection of benz[j]aceanthrylene in urban air and evaluation of its genotoxic potential.

  Lim H; Mattsson Å; Jarvis IWH; Bergvall C; Bottai M; Morales DA; Kummrow F; Umbuzeiro GA; Stenius U; Westerholm R; Dreij K
• Article: CELL DEATH & DISEASE. 2015;6(1):e1616

  The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death

  Xu J; Eriksson SE; Cebula M; Sandalova T; Hedstrom E; Pader I; Cheng Q; Myers CR; Antholine WE; Nagy P; Hellman U; Selivanova G; Lindqvist Y; Arner ESJ
• Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2014;92(9):983-994

  Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats

  Buschmann I; Hackbusch D; Gatzke N; Duelsner A; Trappiel M; Dagnell M; Ostman A; van Huijsduijnen RH; Kappert K
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(33):12157-12162

  Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal

  Salzano S; Checconi P; Hanschmann E-M; Lillig CH; Bowler LD; Chan P; Vaudry D; Mengozzi M; Coppo L; Sacre S; Atkuri KR; Sahaf B; Herzenberg LA; Herzenberg LA; Mullen L; Ghezzi P
• Article: JOURNAL OF CHROMATOGRAPHY A. 2014;1355:100-106

  Benzo[a]pyrene-specific online high-performance liquid chromatography fractionation of air particulate extracts - a tool for evaluating biological interactions.

  Lim H; Bergvall C; Jarvis I; Mattsson Å; Dreij K; Stenius U; Westerholm R
• Review: TOXICOLOGY. 2014;321:27-39

  Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment.

  Jarvis IWH; Dreij K; Mattsson Å; Jernström B; Stenius U
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1840(7):2105-2111

  Serum thioredoxin reductase levels increase in response to chemically induced acute liver injury

  Sun K; Eriksson SE; Tan Y; Zhang L; Arner ESJ; Zhang J
• Article: MOLECULAR PHARMACOLOGY. 2014;85(6):932-945

  The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

  Wang X; Stafford W; Mazurkiewicz M; Fryknas M; Brjnic S; Zhang X; Gullbo J; Larsson R; Arner ESJ; D'Arcy P; Linder S
• Article: CELL DEATH & DISEASE. 2014;5(5):e1235

  Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H₂O₂

  Peng X; Mandal PK; Kaminskyy VO; Lindqvist A; Conrad M; Arner ESJ
• Article: BMC GENOMICS. 2014;15(1):391

  Identification of candidate risk gene variations by whole-genome sequence analysis of four rat strains commonly used in inflammation research

  Backdahl L; Ekman D; Jagodic M; Olsson T; Holmdahl R
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(19):6964-6969

  Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase

  Pader I; Sengupta R; Cebula M; Xu J; Lundberg JO; Holmgren A; Johansson K; Arner ESJ
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(19):6976-6981

  Redox active motifs in selenoproteins

  Li F; Lutz PB; Pepelyayeva Y; Arner ESJ; Bayse CA; Rozovsky S
• Article: ACTA OTO-LARYNGOLOGICA. 2014;134(5):448-454

  Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures

  Dammeyer P; Hellberg V; Wallin I; Laurell G; Shoshan M; Ehrsson H; Arner ESJ; Kirkegaard M
• Review: ANTIOXIDANTS & REDOX SIGNALING. 2014;20(13):1994-2010

  Regulation of Protein Tyrosine Phosphatase Oxidation in Cell Adhesion and Migration

  Frijhoff J; Dagnell M; Godfrey R; Ostman A
• Article: BLOOD. 2014;123(17):e46-e57

  High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis

  Prasad P; Ronnerblad M; Arner E; Itoh M; Kawaji H; Lassmann T; Daub CO; Forrest ARR; Lennartsson A; Ekwall K
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;69:67-76

  Sepp1^UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

  Kurokawa S; Eriksson S; Rose KL; Wu S; Motley AK; Hill S; Winfrey VP; McDonald WH; Capecchi MR; Atkins JF; Arner ESJ; Hill KE; Burk RF
• Article: CELL DEATH AND DIFFERENTIATION. 2014;21(4):612-623

  sROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

  Shi Y; Nikulenkov F; Zawacka-Pankau J; Li H; Gabdoulline R; Xu J; Eriksson S; Hedstroem E; Issaeva N; Kel A; Arner ESJ; Selivanova G
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2014;68:268-277

  The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation

  Frijhoff J; Dagnell M; Augsten M; Beltrami E; Giorgio M; Ostman A
• Published conference paper: AMINO ACIDS. 2014;46(2):429-439

  The control of hyperhomocysteinemia through thiol exchange mechanisms by mesna

  Di Giuseppe D; Priora R; Coppo L; Ulivelli M; Bartalini S; Summa D; Margaritis A; Frosali S; Di Simplicio P
• Book chapter: ENCYCLOPEDIA OF CANCER. 2014;p. 1-4

  Thioredoxin System

  Arnér ESJ; Holmgren A
• Article: PLOS ONE. 2014;9(4):e87843

  New perspectives in the renin-angiotensin-aldosterone system (RAAS) I: endogenous angiotensin converting enzyme (ACE) inhibition.

  Fagyas M; Úri K; Siket IM; Daragó A; Boczán J; Bányai E; Édes I; Papp Z; Tóth A
• Article: PLOS ONE. 2014;9(4):e87845

  New perspectives in the renin-angiotensin-aldosterone system (RAAS) IV: circulating ACE2 as a biomarker of systolic dysfunction in human hypertension and heart failure.

  Úri K; Fagyas M; Mányiné Siket I; Kertész A; Csanádi Z; Sándorfi G; Clemens M; Fedor R; Papp Z; Édes I; Tóth A; Lizanecz E
• Article: PLOS ONE. 2014;9(4):e87844

  New perspectives in the renin-angiotensin-aldosterone system (RAAS) II: albumin suppresses angiotensin converting enzyme (ACE) activity in human.

  Fagyas M; Úri K; Siket IM; Fülöp GÁ; Csató V; Daragó A; Boczán J; Bányai E; Szentkirályi IE; Maros TM; Szerafin T; Édes I; Papp Z; Tóth A
• Article: PLOS ONE. 2014;9(4):e93719

  New perspectives in the renin-angiotensin-aldosterone system (RAAS) III: endogenous inhibition of angiotensin converting enzyme (ACE) provides protection against cardiovascular diseases.

  Fagyas M; Úri K; Siket IM; Daragó A; Boczán J; Bányai E; Édes I; Papp Z; Tóth A
• Article: NUCLEIC ACIDS RESEARCH. 2013;41(21):9800-9811

  Wobble decoding by the Escherichia coli selenocysteine insertion machinery

  Xu J; Croitoru V; Rutishauser D; Cheng Q; Arner ESJ
• Article: CELL DEATH & DISEASE. 2013;4(10):e881

  APR-246/PRIMA-1^MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

  Peng X; Zhang M-Q; Conserva F; Hosny G; Selivanova G; Bykov VJN; Arner ESJ; Wiman KG
• Book chapter: SELENIUM IN THE ENVIRONMENT AND HUMAN HEALTH. 2013;p. 167-169

  The selenoprotein thioredoxin reductase as a key regulator of cellular signaling pathways

  Arnér E
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2013;63:369-380

  A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

  Iverson SV; Eriksson S; Xu J; Prigge JR; Talago EA; Meade TA; Meade ES; Capecchi MR; Arner ESJ; Schmidt EE
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13398-13403

  Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling

  Dagnell M; Frijhoff J; Pader I; Augsten M; Boivin B; Xu J; Mandal PK; Tonks NK; Hellberg C; Conrad M; Arner ESJ; Ostman A
• Article: CELL COMMUNICATION AND SIGNALING. 2013;11:49

  Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

  Krueger J; Trappiel M; Dagnell M; Stawowy P; Meyborg H; Boehm C; Bhanot S; Ostman A; Kintscher U; Kappert K
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(7):1239-1248

  The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats

  Hoffmann MH; Bruns H; Baeckdahl L; Neregard P; Niederreiter B; Herrmann M; Catrina AI; Agerberth B; Holmdahl R
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2013;60:183-194

  Redox activation of Fe(III)-thiosemicarbazones and Fe(III)-bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping

  Myers JM; Cheng Q; Antholine WE; Kalyanaraman B; Filipovska A; Arner ESJ; Myers CR
• Editorial comment: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2013;1830(6):III-IV

  BBA General Subjects - Changing of the Guard at the Publishing Palace

  Arner ESJ
• Doctoral thesis: 2013

  Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling

  Dagnell M
• Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:51.14

  Adoptive transfers reveal dual roles in the protection against arthritis induction in the DACP rat

  Norin U; Rintisch C; Tuncel J; Backdahl L; Ekman D; Holmdahl R
• Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:51.4

  Defining epigenome responses in T-cell arthritogenicity: in search for effectors of autoimmunity

  Backdahl L; Holmdahl R
• Journal article: GASTROENTEROLOGY. 2013;144(5):s-193

  1032 Host-Environment Interactions Shape the Risk for Ulcerative Colitis: Results From a Twin Epigenome-Wide Association Study

  Haesler R; Feng Z; Bäckdahl L; Spehlmann ME; Franke A; Teschendorff A; Rakyan V; Down TA; Wilson GA; Feber A; Beck S; Schreiber S; Rosenstiel PC
• Article: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(12):1385-1399

  Neuroendocrine Profile in a Rat Model of Psychosocial Stress: Relation to Oxidative Stress

  Colaianna M; Schiavone S; Zotti M; Tucci P; Morgese MG; Baeckdahl L; Holmdahl R; Krause K-H; Cuomo V; Trabace L
• Review: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(12):1463-1474

  Hydrogen Peroxide As an Immunological Transmitter Regulating Autoreactive T Cells

  Holmdahl R; Sareila O; Pizzolla A; Winter S; Hagert C; Jaakkola N; Kelkka T; Olsson LM; Wing K; Backdahl L
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(16):11312-11324

  Multilevel Regulation of 2-Cys Peroxiredoxin Reaction Cycle by S-Nitrosylation

  Engelman R; Weisman-Shomer P; Ziv T; Xu J; Arner ESJ; Benhar M
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(14):10002-10011

  The Rare TXNRD1_v3 ("v3") Splice Variant of Human Thioredoxin Reductase 1 Protein Is Targeted to Membrane Rafts by N-Acylation and Induces Filopodia Independently of Its Redox Active Site Integrity

  Cebula M; Moolla N; Capovilla A; Arner ESJ
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1830(3):2562-2573

  Site-specifically ¹¹C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death

  Cheng Q; Lu L; Grafstrom J; Olofsson MH; Thorell J-O; Samen E; Johansson K; Ahlzen H-S; Linder S; Arner ESJ; Stone-Elander S
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;430(1):90-94

  Simvastatin inhibits the core promoter of the TXNRD1 gene and lowers cellular TrxR activity in HepG2 cells

  Ekstrom L; Johansson M; Monostory K; Rundlof A-K; Arner ESJ; Bjorkhem-Bergman L
• Article: ANTIOXIDANTS & REDOX SIGNALING. 2012;17(10):1407-1416

  Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury.

  Locy ML; Rogers LK; Prigge JR; Schmidt EE; Arnér ESJ; Tipple TE
• Journal article: GENOME RESEARCH. 2012;22(11):2130-2137

  A functional methylome map of ulcerative colitis.

  Häsler R; Feng Z; Bäckdahl L; Spehlmann ME; Franke A; Teschendorff A; Rakyan VK; Down TA; Wilson GA; Feber A; Beck S; Schreiber S; Rosenstiel P
• Article: BIOCHEMICAL JOURNAL. 2012;447(1):167-174

  Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase

  Peng X; Xu J; Arner ESJ
• Article: JOURNAL OF NUCLEAR MEDICINE. 2012;53(9):1446-1453

  HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled Sel-tagged affibody molecule.

  Wållberg H; Grafström J; Cheng Q; Lu L; Martinsson Ahlzén H-S; Samén E; Thorell J-O; Johansson K; Dunås F; Olofsson MH; Stone-Elander S; Arnér ESJ; Ståhl S
• Article: PLOS ONE. 2012;7(8):e42151

  Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts.

  Cheng Q; Lu L; Grafström J; Olofsson MH; Thorell J-O; Samén E; Johansson K; Ahlzén H-S; Stone-Elander S; Linder S; Arnér ESJ; Sel-tag Imaging Project
• Article: BLOOD. 2012;119(19):4499-4511

  Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/PTPRJ

  Godfrey R; Arora D; Bauer R; Stopp S; Mueller JP; Heinrich T; Boehmer S-A; Dagnell M; Schnetzke U; Scholl S; Ostman A; Boehmer F-D
• Article: TRANSLATIONAL PSYCHIATRY. 2012;2(5):e111

  NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology

  Schiavone S; Jaquet V; Sorce S; Dubois-Dauphin M; Hultqvist M; Backdahl L; Holmdahl R; Colaianna M; Cuomo V; Trabace L; Krause K-H
• Article: BIOCHEMICAL PHARMACOLOGY. 2012;83(6):815-820

  Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase

  Xu J; Arner ESJ
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2012;52(4):803-810

  Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1

  Prigge JR; Eriksson S; Iverson SV; Meade TA; Capecchi MR; Arner ESJ; Schmidt EE
• Article: PLOS ONE. 2012;7(1):e30528

  Biochemical discrimination between selenium and sulfur 2: mechanistic investigation of the selenium specificity of human selenocysteine lyase.

  Johansson A-L; Collins R; Arnér ESJ; Brzezinski P; Högbom M
• Article: PLOS ONE. 2012;7(1):e30581

  Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase.

  Collins R; Johansson A-L; Karlberg T; Markova N; van den Berg S; Olesen K; Hammarström M; Flores A; Schüler H; Schiavone LH; Brzezinski P; Arnér ESJ; Högbom M
• Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2011;51:S123

  FLT3-ITD Mediated Transformation in Acute Myeloid Leukemia Involves Oxidation of the FLT3 Antagonist PTP, DEP-1: a Novel Redox Circuit in Cancer Cells

  Godfrey R; Arora D; Bauer R; Stopp S; Heinrich T; Mueller JP; Dagnell M; Scholl S; Oestman A; Boehmer F-D
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2011;51:S113

  Thioredoxin Reductase Inhibition Induces Nrf2-mediated Antioxidant Responses in Murine Transformed Clara Cells

  Locy ML; Rogers LK; Nelin LD; Prigge JR; Schmidt EE; Arner ESJ; Tipple TE
• Article: BIOCHEMICAL SOCIETY TRANSACTIONS. 2011;39(5):1268-1272

  Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism

  Coppo L; Ghezzi P
• Article: ANTI-CANCER DRUGS. 2011;22(8):732-740

  Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy

  Wang L; Fu J-N; Wang J-Y; Jin C-J; Ren X-Y; Tan Q; Li J; Yin H-W; Xiong K; Wang T-Y; Liu X-M; Zeng H-H
• Article: PHARMACOLOGICAL RESEARCH. 2011;64(3):289-297

  In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways

  Priora R; Margaritis A; Frosali S; Coppo L; Summa D; Di Giuseppe D; Aldinucci C; Pessina G; Di Stefano A; Di Simplicio P
• Conference publication: TOXICOLOGY LETTERS. 2011;205:S55

  Chelating agents regenerate mammalian thioredoxin reductase inhibited by mercury: Comparison with selenite effects on treatment of mercury poisoning

  Carvalho C; Lu J; Arner E; Holmgren A
• Other: ANTIOXIDANTS & REDOX SIGNALING. 2011;15(3):845-851

  Redox Pioneer: Professor Arne Holmgren

  Arner ESJ
• Article: INVESTIGATIONAL NEW DRUGS. 2011;29(4):627-636

  Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest

  Fu J-N; Li J; Tan Q; Yin H-W; Xiong K; Wang T-Y; Ren X-Y; Zeng H-H
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2011;3(83):83ra40

  Functional Regulatory T Cells Produced by Inhibiting Cyclic Nucleotide Phosphodiesterase Type 3 Prevent Allograft Rejection

  Feng G; Nadig SN; Backdahl L; Beck S; Francis RS; Schiopu A; Whatcott A; Wood KJ; Bushell A
• Article: CELLULAR SIGNALLING. 2011;23(5):820-826

  Hypoxia followed by re-oxygenation induces oxidation of tyrosine phosphatases

  Sandin A; Dagnell M; Gonon A; Pernow J; Stangl V; Aspenstrom P; Kappert K; Ostman A
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(9):1114-1123

  Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay

  Prast-Nielsen S; Dexheimer TS; Schultz L; Stafford WC; Cheng Q; Xu J; Jadhav A; Arner ESJ; Simeonov A
• Journal article: CHEMINFORM. 2011;42(17):no

  ChemInform Abstract: Human Protein Atlas of Redox Systems — What Can Be Learnt?

  Dammeyer P; Arner ESJ
• Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2011;183(8):1092-1102

  Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases

  ten Freyhaus H; Dagnell M; Leuchs M; Vantler M; Berghausen EM; Caglayan E; Weissmann N; Dahal BK; Schermuly RT; Oestman A; Kappert K; Rosenkranz S
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(6):689-699

  Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors

  Rackham O; Shearwood A-MJ; Thyer R; McNamara E; Davies SMK; Callus BA; Miranda-Vizuete A; Berners-Price SJ; Cheng Q; Arner ESJ; Filipovska A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(3):1064-1069

  Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans

  Stenvall J; Fierro-Gonzalez JC; Swoboda P; Saamarthy K; Cheng Q; Cacho-Valadez B; Arner ESJ; Persson OP; Miranda-Vizuete A; Tuck S
• Book chapter: ENCYCLOPEDIA OF CANCER. 2011;p. 3670-3671

  Thioredoxin System

  Arnér ESJ; Holmgren A
• Book chapter: SELENIUM. 2011;p. 1-19

  History of Selenium Research

  Arnér ESJ
• Journal article: PLOS ONE. 2011;6(10):e26002

  Genome-wide screen for differential DNA methylation associated with neural cell differentiation in mouse.

  Cortese R; Lewin J; Bäckdahl L; Krispin M; Wasserkort R; Eckhardt F; Beck S
• Article: PHARMACOLOGICAL RESEARCH. 2011;63(1):77-84

  The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions

  Margaritis A; Priora R; Frosali S; Di Giuseppe D; Summa D; Coppo L; Di Stefano A; Di Simplicio P
• Article: DIFFERENTIATION. 2011;81(1):49-56

  Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity

  Yin H; Li J; Xiong K; Wang L; Wang T; Tan Q; Fu J; Ren X; Zeng H
• Article: FASEB JOURNAL. 2011;25(1):370-381

  Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning

  Carvalho CML; Lu J; Zhang X; Arner ESJ; Holmgren A
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1810(1):111-138

  Human Protein Atlas of redox systems - What can be learnt?

  Dammeyer P; Arner ESJ
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2010;49(11):1765-1778

  Noble metal targeting of thioredoxin reductase - covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin

  Prast-Nielsen S; Cebula M; Pader I; Arner ESJ
• Doctoral thesis: 2010

  Development of a Sel-tag for multimodality imaging and studies of mammalian thioredoxin reductase 1

  Cheng Q
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15774-15779

  12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

  Conrad M; Sandin A; Foerster H; Seiler A; Frijhoff J; Dagnell M; Bornkamm GW; Radmark O; van Huijsduijnen RH; Aspenstrom P; Boehmer F; Ostman A
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(28):21708-21723

  The Selenium-independent Inherent Pro-oxidant NADPH Oxidase Activity of Mammalian Thioredoxin Reductase and Its Selenium-dependent Direct Peroxidase Activities

  Cheng Q; Antholine WE; Myers JM; Kalyanaraman B; Arner ESJ; Myers CR
• Article: INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2010;391(1-2):292-304

  Preparation of tri-block copolymer micelles loading novel organoselenium anticancer drug BBSKE and study of tissue distribution of copolymer micelles by imaging in vivo method

  Liu M; Fu J; Li J; Wang L; Tan Q; Ren X; Peng Z; Zeng H
• Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1296-1303

  Selenoproteins-What unique properties can arise with selenocysteine in place of cysteine?

  Arner ESJ
• Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2010;242(3):333-343

  The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats

  Priora R; Coppo L; Margaritis A; Di Giuseppe D; Frosali S; Summa D; Heo J; Di Simplicio P
• Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2010;49:S98-S99

  The Interactions of Thioredoxin Reductase with Quinones and Acrolein: Covalent Adducts and Stimulation of NADPH Oxidase Activity

  Myers CR; Cheng Q; Myers JM; Antholine WE; Arner ESJ
• Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2010;473:149-159

  MEASUREMENT OF MIXED DISULFIDES INCLUDING GLUTATHIONYLATED PROTEINS

  Priora R; Coppo L; Salzano S; Di Simplicio P; Ghezzi P
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2009;68(12):1925-1932

  Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data

  Backdahl L; Guo JP; Jagodic M; Becanovic K; Ding B; Olsson T; Lorentzen JC
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;47(11):1661-1671

  High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

  Eriksson SE; Prast-Nielsen S; Flaberg E; Szekely L; Arner ESJ
• Article: CELL CYCLE. 2009;8(21):3584-3591

  p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA

  Hedstrom E; Eriksson S; Zawacka-Pankau J; Arner ESJ; Selivanova G
• Editorial comment: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1790(11):1387-1388

  Special issue on selenoprotein expression and function Preface

  Lillig CH; Arner E
• Article: JOURNAL OF MEDICINAL CHEMISTRY. 2009;52(20):6474-6483

  Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis

  Rai G; Sayed AA; Lea WA; Luecke HF; Chakrapani H; Prast-Nielsen S; Jadhav A; Leister W; Shen M; Inglese J; Austin CP; Keefer L; Arner ESJ; Simeonov A; Maloney DJ; Williams DL; Thomas CJ
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1793(10):1588-1596

  The human thioredoxin reductase-1 splice variant TXNRD1_v3 is an atypical inducer of cytoplasmic filaments and cell membrane filopodia

  Damdimopoulou PE; Miranda-Vizuete A; Arner ESJ; Gustafsson J-A; Damdimopoulos AE
• Article: ALLERGY. 2009;64(6):919-926

  Prolonged antigen-exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice

  Thunberg S; Neimert-Andersson T; Cheng Q; Wermeling F; Bergstrom U; Swedin L; Dahlen S-E; Arner E; Scheynius A; Karlsson MCI; Gafvelin G; van Hage M; Gronlund H
• Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1790(6):495-526

  Focus on mammalian thioredoxin reductases - Important selenoproteins with versatile functions

  Arner ESJ
• Article: EPIGENETICS. 2009;4(4):248-254

  Gene body methylation of the dimethylarginine dimethylamino-hydrolase 2 (Ddah2) gene is an epigenetic biomarker for neural stem cell differentiation.

  Bäckdahl L; Herberth M; Wilson G; Tate P; Campos LS; Cortese R; Eckhardt F; Beck S
• Conference publication: CANCER RESEARCH. 2009;69

  Evaluation of plain platinum, palladium and gold salts as inhibitors of mammalian thioredoxin reductase: Implications for clinically used drugs and the development of new anticancer agents

  Prast-Nielsen S; Arner E
• Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2009;50(4):337-348

  Exposure of HepG2 Cells to Low Levels of PAH-Containing Extracts from Contaminated Soils Results in Unpredictable Genotoxic Stress Responses

  Mattsson A; Lundstedt S; Stenius U
• Article: EXPERIMENTAL CELL RESEARCH. 2009;315(8):1360-1371

  Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1

  Wallenborg K; Vlachos P; Eriksson S; Huijbregts L; Arner ESJ; Joseph B; Hermanson O
• Article: CHINESE JOURNAL OF CANCER. 2009;28(5):472-477

  [Correlation of plasma thioredoxin reductase activity to growth of H22 hepatocellular carcinoma xenografts in Kunming mice].

  Tan Q; Ren X-Y; Li J; Wang F; Deng S-J; Zeng H-H
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;46(7):893-904

  Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1

  Rengby O; Cheng Q; Vahter M; Jornvall H; Arner ESJ
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(6):3998-4008

  Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1

  Cheng Q; Sandalova T; Lindqvist Y; Arner ESJ
• Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;177(1):40-47

  H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides

  Mattsson A; Jernstrom B; Cotgreave IA; Bajak E
• Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2009;101(1):37-47

  Cisplatin and Oxaliplatin Toxicity: Importance of Cochlear Kinetics as a Determinant for Ototoxicity

  Hellberg V; Wallin I; Eriksson S; Hernlund E; Jerremalm E; Berndtsson M; Eksborg S; Arner ESJ; Shoshan M; Ehrsson H; Laurell G
• Book chapter: ENCYCLOPEDIA OF CANCER. 2009;p. 2954-2956

  Thioredoxin System

  Arnér ESJ; Holmgren A
• Conference publication: FREE RADICAL RESEARCH. 2009;43:63

  Drug-specific responses to cytotoxic agents mediated by high levels of thioredoxin reductase 1 in human A549 cancer cells

  Eriksson S; Prast-Nielsen S; Flaberg E; Szekely L; Arner E
• Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2009;41(1):176-184

  Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation.

  Bäckdahl L; Bushell A; Beck S
• Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(12):1742-1749

  Cellular distribution of the C-type II lectin dendritic cell immunoreceptor (DCIR) and its expression in the rheumatic joint: identification of a subpopulation of DCIR plus T cells

  Eklow C; Makrygiannakis D; Backdahl L; Padyukov L; Ulfgren A-K; Lorentzen JC; Malmstrom V
• Doctoral thesis: 2008

  Polycyclic aromatic hydrocarbons : DNA damage and cell signaling

  Mattsson Å
• Published conference paper: POLYCYCLIC AROMATIC COMPOUNDS. 2008;28(4-5):392-401

  H2AX, MDM2 AND P53 PHOSPHORYLATION ARE DIFFERENTLY AFFECTED BY BAY- AND FJORD-REGION DIOL EPOXIDES DERIVED FROM CARCINOGENIC POLYCYCLIC AROMATIC HYDROCARBONS

  Mattsson A; Malmlof M; Seidel A; Stenius U; Jernstrom B
• Article: BIOCHEMICAL PHARMACOLOGY. 2008;76(9):1097-1109

  The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation

  Cox AG; Brown KK; Arner ESJ; Hampton MB
• Article: GENOME RESEARCH. 2008;18(9):1518-1529

  An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs).

  Rakyan VK; Down TA; Thorne NP; Flicek P; Kulesha E; Gräf S; Tomazou EM; Bäckdahl L; Johnson N; Herberth M; Howe KL; Jackson DK; Miretti MM; Fiegler H; Marioni JC; Birney E; Hubbard TJP; Carter NP; Tavaré S; Beck S
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2008;45(4):494-502

  Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated

  Brown KK; Eriksson SE; Arner ESJ; Hampton MB
• Article: NATURE BIOTECHNOLOGY. 2008;26(7):779-785

  A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis.

  Down TA; Rakyan VK; Turner DJ; Flicek P; Li H; Kulesha E; Gräf S; Johnson N; Herrero J; Tomazou EM; Thorne NP; Bäckdahl L; Herberth M; Howe KL; Jackson DK; Miretti MM; Marioni JC; Birney E; Hubbard TJP; Durbin R; Tavaré S; Beck S
• Article: BMC MEDICAL GENOMICS. 2008;1:19

  Generation of a genomic tiling array of the human major histocompatibility complex (MHC) and its application for DNA methylation analysis.

  Tomazou EM; Rakyan VK; Lefebvre G; Andrews R; Ellis P; Jackson DK; Langford C; Francis MD; Bäckdahl L; Miretti M; Coggill P; Ottaviani D; Sheer D; Murrell A; Beck S
• Article: ARTHRITIS & RHEUMATOLOGY. 2008;58(5):1343-1353

  Profound and paradoxical impact on arthritis and autoimmunity of the rat antigen-presenting lectin-like receptor complex

  Guo JP; Backdahl L; Marta M; Mathsson L; Ronnelid J; Lorentzen JC
• Article: PLOS ONE. 2008;3(4):e1846

  Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells

  Anestal K; Prast-Nielsen S; Cenas N; Arner ESJ
• Corrigendum: CANCER RESEARCH. 2008;68(4):1245

  The FBXW7 gene is mutated in a variety of human tumors (vol 67, pg 9006, 2007)

  Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Capeda D; Fiegl H; Dafou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(5):2814-2821

  Induction of cell membrane protrusions by the N-terminal glutaredoxin domain of a rare splice variant of human thioredoxin reductase 1

  Dammeyer P; Damdimopoulos AE; Nordman T; Jimenez A; Miranda-Vizuete A; Arner ESJ
• Article: CANCER RESEARCH. 2007;67(19):9006-9012

  FBXW7/hCDC4 is a general tumor suppressor in human cancer

  Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Cepeda D; Fiegl H; Dofou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C
• Journal article: PLOS MEDICINE. 2007;4(8):1418

  Thioredoxin glutathione reductase from Schistosoma mansoni:: An essential parasite enzyme and a key drug target (vol 4, art no e206, 2007)

  Kuntz AN; Davioud-Charvet E; Sayed AA; Califf LL; Dessolin J; Arner ESJ; Williams DL
• Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(8):2620-2632

  Association of arthritis with a gene complex encoding C-type lectin-like receptors

  Lorentzen JC; Flornes L; Eklow C; Backdahl L; Ribbhammar U; Guo JP; Smolnikova M; Dissen E; Seddighzadeh M; Brookes AJ; Alfredsson L; Klareskog L; Padyukov L; Fossum S
• Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:293-294

  The APLEC gene complex regulates multiple forms of rat polyarthritis and multiple disease phenotypes

  Guo J; Backdahl L; Ribbhammar U; Lorentzen JC
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2007;43(1):100-110

  Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2

  Weibrecht I; Boehmer S-A; Dagnell M; Kappert K; Ostman A; Boehmer F-D
• Article: PLOS MEDICINE. 2007;4(6):e206-1086

  Thioredoxin glutathione reductase from schistosoma mansoni:: An essential parasite enzyme and a key drug target

  Kuntz AN; Davioud-Charvet E; Sayed AA; Califf LL; Dessolin J; Arner ESJ; Williams DL
• Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2007;459(2):178-188

  Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney

  Crosley LK; Meplan C; Nicol F; Rundlof AK; Arner ESJ; Hesketh JE; Arthur JR
• Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2007;73(2):432-441

  Titration and conditional knockdown of the prfB gene in Escherichia coli:: Effects on growth and overproduction of the recombinant mammalian selenoprotein thioredoxin reductase

  Rengby O; Arner ESJ
• Article: CHEMBIOCHEM. 2006;7(12):1976-1981

  Selenolthiol and dithiol C-terminal tetrapeptide motifs for one-step purification and labeling of recombinant proteins produced in E. coli

  Cheng Q; Johansson L; Thorell J-O; Fredriksson A; Samen E; Stone-Elander S; Arner ESJ
• Review: SEMINARS IN CANCER BIOLOGY. 2006;16(6):420-426

  The thioredoxin system in cancer

  Arner ESJ; Holmgren A
• Editorial comment: SEMINARS IN CANCER BIOLOGY. 2006;16(6):419

  The thioredoxin system in cancer -: iniroduction to a thematic volume of Seminars in Cancer Biology

  Arner ESJ; Holmgren A
• Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2006;72(10):6554-6559

  Generation of useful insertionally blocked sterol degradation pathway mutants of fast-growing mycobacteria and cloning, characterization, and expression of the terminal oxygenase of the 3-ketosteroid 9alpha-hydroxylase in Mycobacterium smegmatis mc(2)155.

  Andor A; Jekkel A; Hopwood DA; Jeanplong F; Ilkoy E; Kónya A; Kurucz I; Ambrus G
• Conference publication: ARTHRITIS & RHEUMATOLOGY. 2006;54(9):S301

  A gene complex encoding C-type lectin-like receptors associates with arthritis in both rats and humans.

  Lorentzen JC; Flornes L; Eklöw C; Bäckdahl L; Ribbhammar U; Guo JP; Dissen E; Seddighzadeh M; Ulfgren A-K; Smolnikova M; Brookes AJ; Alfredsson L; Klareskog L; Padyukov L; Fossum S
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2006;41(4):649-656

  Studies of an active site mutant of the selenoprotein thioredoxin reductase:: The Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme

  Johansson L; Arscott LD; Ballou DP; Williams CHJ; Arner ESJ
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;346(1):45-50

  Inhibition of the MDR1 transporter by new phenothiazine derivatives.

  Kónya A; Andor A; Sátorhelyi P; Németh K; Kurucz I
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(9):5593-5603

  Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells

  Cenas N; Prast S; Nivinskas H; Sarlauskas J; Arnér ESJ
• Conference publication: FREE RADICAL RESEARCH. 2006;40:S51

  Selenium compromised thioredoxin reductase-derived apoptotic proteins (SecTRAPs): Potent killers of cancer cells

  Arner ESJ
• Book chapter: SELENIUM. 2006;p. 221-230

  Biotechnology of selenocysteine

  Johansson L; Arnér ESJ
• Article: NATURE PROTOCOLS. 2006;1(2):604-613

  Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with ¹¹C

  Cheng Q; Stone-Elander S; Arner ESJ
• Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1726(1):1-13

  Selenocysteine in proteins - properties and biotechnological use

  Johansson L; Gafvelin G; Arnér ESJ
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2005;39(5):696-703

  Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds

  Witte AB; Anestål K; Jerremalm E; Ehrsson H; Arnér ESJ
• Journal article: AFCS-NATURE MOLECULE PAGES. 2005

  Thioredoxin reductase 1

  Arnér E
• Article: FEBS JOURNAL. 2005;272(13):3449-3460

  A mouse model for in vivo tracking of the major dust mite allergen Der p 2 after inhalation

  Johansson L; Svensson L; Bergström U; Jacobsson-Ekman G; Arnér ESJ; van Hage M; Bucht A; Gafvelin G
• Conference publication: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2005;48:S38

  EVALUATION OF NOVEL SELENOLTHIOL AND DITHIOL SEL-TAG VARIANTS FOR PURIFICATION AND ¹¹C-LABELING OF RECOMBINANT PROTEINS PRODUCED IN E. COLI

  Cheng Q; Johansson L; Fredriksson A; Thorell J-O; Stone-Elander S; Arner ESJ
• Doctoral thesis: 2005

  Genetic dissection of experimental arthritis in the DA rat

  Bäckdahl L
• Article: BIOLOGICAL CHEMISTRY. 2005;386(4):333-337

  Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA

  Hofer T; Badouard C; Bajak E; Ravanat JL; Mattsson Å; Cotgreave IA
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(52):54510-54517

  Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells - Effect on cell growth and differentiation

  Nalvarte I; Damdimopoulos AE; Nystöm C; Nordman T; Miranda-Vizuete A; Olsson JM; Eriksson L; Björnstedt M; Arnér ESJ; Spyrou G
• Article: NATURE METHODS. 2004;1(1):61-66

  Exploiting the 21st amino acid - purifying and labeling proteins by selenolate targeting

  Johansson L; Chen CY; Thorell JO; Fredriksson A; Stone-Elander S; Gafvelin G; Arnér ESJ
• Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2004;154(1-2):20

  An advanced intercross line resolves Eae18 into two narrow QTLs syntenic to multiple sclerosis candidate loci

  Jagodic M; Becanovic K; Sheng JR; Wu X; Bäckdahl L; Lorentzen JC; Wallström E; Olsson T
• Article: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2004;70(9):5159-5167

  Assessment of production conditions for efficient use of Escherichia coli in high-yield heterologous recombinant selenoprotein synthesis

  Rengby O; Johansson L; Carlson LA; Serini E; Vlamis-Gardikas A; Kårsnäs P; Arnér ESJ
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;321(1):94-101

  Expression of selenocysteine-containing glutathione S-transferase in Escherichia coli

  Jiang ZH; Arnér ESJ; Mu Y; Johansson L; Shi JM; Zhao SQ; Liu SJ; Wang RY; Zhang TZ; Yan GL; Liu JQ; Shen JC; Luo GM
• Article: JOURNAL OF IMMUNOLOGY. 2004;173(2):1366-1373

  An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci

  Jagodic M; Becanovic K; Sheng JR; Wu XC; Bäckdahl L; Lorentzen JC; Wallström E; Olsson T
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2004;37(1):71-85

  Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: Specific induction of the promoter in human macrophages by oxidized low-density lipoproteins

  Furman C; Rundlöf AK; Larigauderie G; Jaye M; Bricca G; Copin C; Kandoussi AM; Fruchart JC; Arnér ESJ; Rouis M
• Conference publication: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2004;197(3):180

  The major dust mite allergen Der p 2 is differentially distributed after intratracheal delivery in sensitised and non-sensitised mice

  Svensson L; Johansson L; Arnér E; Bergström U; van Hage-Hamsten M; Bucht A; Gafvelin G
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):24152-24162

  Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway

  Thyrell L; Hjortsberg L; Arulampalam V; Panaretakis T; Uhles S; Dagnell M; Zhivotovsky B; Leibiger I; Grandér D; Pokrovskaja K
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2004;36(5):641-656

  Evidence for intriguingly complex transcription of human thioredoxin reductase 1

  Rundlöf AK; Janard M; Miranda-Vizuete A; Arnér ESJ
• Review: ANTIOXIDANTS & REDOX SIGNALING. 2004;6(1):41-52

  Regulation of the mammalian selenoprotein thioredoxin reductase 1 in relation to cellular phenotype, growth, and signaling events

  Rundlöf AK; Arnér ESJ
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(4):2583-2592

  Interactions of quinones with thioredoxin reductase -: A challenge to the antioxidant role of the mammalian selenoprotein

  Cenas N; Nivinskas H; Anusevicius Z; Sarlauskas J; Lederer F; Arnér ESJ
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(22):12618-12623

  Active sites of thioredoxin reductases: Why selenoproteins?

  Gromer S; Johansson L; Bauer H; Arscott LD; Rauch S; Ballou DP; Williams CHJ; Schirmer RH; Arnér ESJ
• Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):291

  The thioredoxin reductase/thioredoxin system is upregulated in atherosclerotic plaques:: Specific induction in human macrophages by oxidized low density lipoproteins

  Furman C; Rundlöf AK; Jaye M; Searfoss G; Yue KT; Larigauderie G; Copin C; Kandoussi AM; Fruchart JC; Arnér ESJ; Rouis M
• Conference publication: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):S228

  High resolution mapping of an arthritis-susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes

  Ribbhammar U; Flornes L; Bäckdahl L; Luthman H; Fossum S; Lorentzen JC
• Article: HUMAN MOLECULAR GENETICS. 2003;12(17):2087-2096

  High resolution mapping of an arthritis susceptibility locus on rat chromosome 4, and characterization of regulated phenotypes

  Ribbhammar U; Flornes L; Bäckdahl L; Luthman H; Fossum S; Lorentzen JC
• Book chapter: CELLULAR IMPLICATIONS OF REDOX SIGNALING. 2003;p. 27-45

  Selenocysteine Insertion and Reactivity: Mammalian Thioredoxin Reductases in Relation to Cellular Redox Signaling

  Arnér ESJ
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(7):1907-1916

  Paradoxical effects of arthritis-regulating chromosome 4 regions on myelin oligodendrocyte glycoprotein-induced encephalomyelitis in congenic rats

  Becanovic K; Bäckdahl L; Wallström E; Aboul-Enein F; Lassmann H; Olsson T; Lorentzen JC
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(18):15966-15972

  Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine

  Anestål K; Arnér ESJ
• Article: ARTHRITIS & RHEUMATOLOGY. 2003;48(2):551-559

  Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains

  Bäckdahl L; Ribbhammar U; Lorentzen JC
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(4):2141-2146

  The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone -: A novel mechanism for defense against oxidative stress

  Xia L; Nordman T; Olsson JM; Damdimopoulos A; Björkhem-Bergman L; Nalvarte I; Eriksson LC; Arnér ESJ; Spyrou G; Björnstedt M
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2003;35:S124

  Induction of apoptosis in cancer cells by selenium compromised thioredoxin reductase

  Anestål K; Arnér E
• Published conference paper: BIOFACTORS. 2003;18(1-4):45-50

  Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase

  Nordman T; Xia L; Björkhem-Bergman L; Damdimopoulos A; Nalvarte I; Arnér ESJ; Spyrou G; Eriksson LC; Björnstedt M; Olsson JM
• Book chapter: ENCYCLOPEDIA OF MOLECULAR BIOLOGY. 2002;p.

  Glutaredoxin

  Holmgren A; Arnér ESJ; Berndt KD
• Book chapter: WILEY ENCYCLOPEDIA OF MOLECULAR MEDICINE. 2002;p.

  Glutaredoxin

  Holmgren A; Arnér ESJ; Berndt KD
• Book chapter: WILEY ENCYCLOPEDIA OF MOLECULAR MEDICINE. 2002;p.

  Thioredoxin

  Arnér ESJ; Holmgren A
• Book chapter: WILEY ENCYCLOPEDIA OF MOLECULAR MEDICINE. 2002;p.

  Thioredoxin Reductase

  Arnér ESJ; Holmgren A
• Book chapter: ENCYCLOPEDIA OF MOLECULAR BIOLOGY. 2002;p.

  Thioredoxin Reductase

  Holmgren A; Arnér ESJ; Berndt KD
• Book chapter: ENCYCLOPEDIA OF MOLECULAR BIOLOGY. 2002;p.

  Thioredoxin

  Holmgren A; Arnér ESJ; Berndt KD
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2002;33:S301

  The mammalian thioredoxin system

  Arnér ESJ
• Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2002;347:226-235

  Recombinant expression of mammalian selenocysteine-containing thioredoxin reductase and other selenoproteins in Escherichia coli

  Arnér ESJ
• Review: FREE RADICAL BIOLOGY AND MEDICINE. 2001;31(11):1287-1312

  Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

  Nordberg J; Arnér ESJ
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2001;31(10):1170-1178

  Analysis of the inhibition of mammalian thioredoxin, thioredoxin reductase, and glutaredoxin by cis-diamminedichloroplatinum (II) and its major metabolite, the glutathione-platinum complex

  Arnér ESJ; Nakamura H; Sasada T; Yodoi J; Holmgren A; Spyrou G
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(32):30542-30551

  The core promoter of human thioredoxin reductase 1

  Rundlöf AK; Carlsten M; Arnér ESJ
• Article: CURRENT PROTOCOLS IN TOXICOLOGY / EDITORIAL BOARD, MAHIN D. MAINES (EDITOR-IN-CHIEF) ... [ET AL.]. 2001;Chapter 7:Unit-7.4.

  Measurement of thioredoxin and thioredoxin reductase.

  Arnér ES; Holmgren A
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(48):37474-37480

  Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma

  Pekkari K; Gurunath R; Arnér ESJ; Holmgren A
• Review: FEBS JOURNAL. 2000;267(20):6102-6109

  Physiological functions of thioredoxin and thioredoxin reductase

  Arnér ESJ; Holmgren A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(11):5854-5859

  Structure and mechanism of mammalian thioredoxin reductase:: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

  Zhong LW; Arnér ESJ; Holmgren A
• Journal article: BIOCHEMICAL JOURNAL. 2000;347(3):661

  Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′ untranslated region

  RUNDLÖF A-K; CARLSTEN M; GIACOBINI MMJ; ARNÉR ESJ
• Article: BIOCHEMICAL JOURNAL. 2000;347(Pt 3):661-668

  Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5′untranslated region

  Rundlöf AK; Carlsten M; Giacobini MMJ; Arnér ESJ
• Article: JOURNAL OF MOLECULAR BIOLOGY. 1999;292(5):1003-1016

  High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes

  Arnér ESJ; Sarioglu H; Lottspeich F; Holmgren A; Böck A
• Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 1999;300:226-239

  Preparation and assay of mammalian thioredoxin and thioredoxin reductase

  Arner ESJ; Zhong LW; Holmgren A
• Article: BIOFACTORS. 1999;10(2-3):219-226

  Superoxide production by dinitrophenyl-derivatized thioredoxin reductase -: a model for the mechanism and correlation to immunostimulation by dinitrohalobenzenes

  Arnér ESJ
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(18):10835-10842

  Mammalian thioredoxin reductase is irreversibly inhibited by dinitrohalobenzenes by alkylation of both the redox active selenocysteine and its neighboring cysteine residue

  Nordberg J; Zhong L; Holmgren A; Arnér ESJ
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(15):8581-8591

  Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue

  Zhon LW; Arnér ESJ; Ljung J; Åslund F; Holmgren A
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1996;225(1):268-274

  Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase

  Arner ESJ; Nordberg J; Holmgren A
• Review: LEUKEMIA & LYMPHOMA. 1996;21(3-4):225-231

  On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment

  Arner ESJ
• Other: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(8):3479-3482

  1-CHLORO-2,4-DINITROBENZENE IS AN IRREVERSIBLE INHIBITOR OF HUMAN THIOREDOXIN REDUCTASE - LOSS OF THIOREDOXIN DISULFIDE REDUCTASE-ACTIVITY IS ACCOMPANIED BY A LARGE INCREASE IN NADPH OXIDASE ACTIVITY

  ARNER ESJ; BJORNSTEDT M; HOLMGREN A
• Review: PHARMACOLOGY & THERAPEUTICS. 1995;67(2):155-186

  MAMMALIAN DEOXYRIBONUCLEOSIDE KINASES

  ARNER ESJ; ERIKSSON S
• Article: EUROPEAN JOURNAL OF CANCER. 1995;31A(2):202-208

  EXPRESSION OF DEOXYCYTIDINE KINASE AND PHOSPHORYLATION OF 2-CHLORODEOXYADENOSINE IN HUMAN NORMAL AND TUMOR-CELLS AND TISSUES

  SPASOKOUKOTSKAJA T; ARNER ESJ; BROSJO O; GUNVEN P; JULIUSSON G; LILIEMARK J; ERIKSSON S
• Journal article: BRITISH JOURNAL OF HAEMATOLOGY. 1994;87(4):715-718

  PHOSPHORYLATION OF 2-CHLORODEOXYADENOSINE (CDA) IN EXTRACTS OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF LEUKEMIC PATIENTS

  ARNER ESI; SPASOKOUKOTSKAJA T; JULIUSSON G; LILIEMARK J; ERIKSSON S
• Journal article: ADVANCES IN ENZYME REGULATION. 1994;34:13-25

  PROPERTIES AND LEVELS OF DEOXYNUCLEOSIDE KINASES IN NORMAL AND TUMOR-CELLS - IMPLICATIONS FOR CHEMOTHERAPY

  ERIKSSON S; ARNER E; SPASOKOUKOTSKAJA T; WANG LY; KARLSSON A; BROSJO O; GUNVEN P; JULUSSON G; LILIEMARK J
• Book chapter: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1994;p. 201-204

  Mitochondrial versus cytosolic activities of deoxyribonucleoside salvage enzymes.

  Söderlund JC; Arnér ES
• Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1993;197(3):1499-1504

  DEOXYCYTIDINE AND 2',3'-DIDEOXYCYTIDINE METABOLISM IN HUMAN MONOCYTE-DERIVED MACROPHAGES A STUDY OF BOTH ANABOLIC AND CATABOLIC PATHWAYS

  ARNER ESJ; ERIKSSON S
• Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1993;268(30):22847-22852

  SUBSTRATE-SPECIFICITY OF MITOCHONDRIAL 2'-DEOXYGUANOSINE KINASE - EFFICIENT PHOSPHORYLATION OF 2-CHLORODEOXYADENOSINE

  WANG LY; KARLSSON A; ARNER ESJ; ERIKSSON S
• Journal article: INTERNATIONAL JOURNAL OF CLINICAL PHARMACY. 1993;15(Suppl 4):f15-f30

  Abstracts of poster presentations

  Agostinho AB; Rosi F; Tabucchi A; Carlucci F; Pizzichini M; Arnér ESJ; Eriksson S; Barankiewicz J; Trembacz H; Zwierzchowski L; Bergman AM; van Haperen VWTR; Veerman G; Vermorken JB; Peters GJ; Bory C; Chantin C; Rocca JL; Bzowska A; Ananlev AV; Ramzaeva N; Alksins E; Maurins JA; Kulikowska E; Shugar D; Davies PM; Fairbanks LD; Simmonds HA; De Graaf TW; Van Dijk W; de Jong D; Huysmans F; De Abreu R; Monnens L; Dijkman H; van Liebergen F; Assmann K; Duley JA; Hanefeld F; Fabianowska-Majewska K; Duley AJ; Greger J; Wasiak T; Gathof BS; Ried T; Zwieauer K; Gresser U; Griesmacher A; Weigel G; Müller MM; Gross M; Empl W; Guisan B; Roch-Ramel F; Harley EH; Baumgarten I; Kaletha K; Nagel-Starczynowska G; Karlsson A; Lambooy L; Boerbooms A; De Abreu R; van de Putte L; Stolk J; vd Pulte L; Komissarov AA; Romanova DV; Debabov VG; Kozlov AM; Sokolov VB; Aksinenko AY; Fetisov VI; Komoriya K; Osada Y; Hasegawa M; Kondo S; Couch RC; Griffin TB; Lakaschus G; Löffler HG; Löffler M; Jiménez ML; Salinero MA; Guilarte JS; Matesanz JP; Medina LV; Galiana JR; Marlewski M; Smolenski RT; Swierczynski J; Rutkowski B; Zydowo MM; Micheli V; Pescaglini M; Sestini S; Jacomelli G; Magagnoli C; Pompucci G; Hayek G; Mimouni M; Boptemps F; Van den Berghe G; Miranda ME; Mateos FA; Herrero E; González A; Puig JG; Miscetti P; Minelli A; Proietti A; Moroni M; Mezzasoma I; Moro JF; Noam I; Cameron JS; McBride MB; Mathew CGP; Ogg CS; Puig JG; Miranda ME; Mateos FA; Luzi L; Noordhuis P; Kazemier K; Kaspers GJL; Overgaard-Hansen K; Marcussen M; Klenow H; Pelatti A; Quaratino CP; D'Amario C; Tentarelli R; Giacomello A; Rocchigiani M; Iacomelli G; Pandolfi ML; Arezzini L; Terzuoli L; Pagani R; Di Sciascio N; Colosimo A; Ranieri-Paggi M; Ronca F; Brown PE; Moir AJG; Raggi A; Schwendel A; Grune T; Siems WG; Holzhuetter HG; Sebesta I; Krijt J; Vondrak K; Kmoch S; Hrebicek M; Senatore G; Del Lucchese G; Martini C; Lucacchini A; Siems WG; Mertsch K; Blasig I; Grune T; Skladanowski AC; Hoffmann CS; Krass JD; Makarewicz W; Jastorff B; Slingerland RJ; Bodlaender JM; Van Lenthe H; Elzinga L; Van Kuilenburg ABP; Voûte PA; Van Gennip AH; Smid K; van der Wilt CL; Aherne GW; Pinedo HM; Sorqi ML; Rucci C; Zoppini A; Staub M; Sasvári-Székely M; Spasokukockaja T; Hrabák A; Stolk JN; De Abreu RA; De Koning DGM; Lambooy LHM; Kerstens PJSM; Boerbooms AMT; van de Putte LBA; Szüts P; Szirovicza É; åbrahám CS; Havass Z; Jezewska MM; Van Acker KJ; Eyskens FJ; Verkerk RH; Scharpé SS; van Kuppevelt TH; Veerkamp JH; Sabina RL; Van Laar JAM; Mayhew E; Durrani FA; Peters GJ; Rustum YM; Wang JZ; Leoncini R; Vannoni D; Marinello E
• Journal article: ANALYTICAL BIOCHEMISTRY. 1993;210(1):102-105

  CATABOLISM OF DEOXYCYTIDINE IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS AND ITS INTERFERENCE WITH THE DETERMINATION OF INSITU THYMIDYLATE SYNTHASE ACTIVITY

  ARNER ESJ; ERIKSSON S
• Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1992;188(2):712-718

  SELECTIVE ASSAYS FOR THYMIDINE KINASE-1 AND KINASE-2 AND DEOXYCYTIDINE KINASE AND THEIR ACTIVITIES IN EXTRACTS FROM HUMAN-CELLS AND TISSUES

  ARNER ESJ; SPASOKOUKOTSKAJA T; ERIKSSON S
• Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1992;267(16):10968-10975

  THYMIDINE AND 3'-AZIDO-3'-DEOXYTHYMIDINE METABOLISM IN HUMAN PERIPHERAL-BLOOD LYMPHOCYTES AND MONOCYTE-DERIVED MACROPHAGES - A STUDY OF BOTH ANABOLIC AND CATABOLIC PATHWAYS

  ARNER ESJ; VALENTIN A; ERIKSSON S
• Journal article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1991;309B:239-243

  Expression and substrate specificities of human thymidine kinase 1, thymidine kinase 2 and deoxycytidine kinase.

  Eriksson S; Munch-Petersen B; Kierdaszuk B; Arnér E
• Journal article: EXPERIMENTAL CELL RESEARCH. 1988;178(2):335-342

  DEOXYCYTIDINE KINASE IS CONSTITUTIVELY EXPRESSED IN HUMAN-LYMPHOCYTES - CONSEQUENCES FOR COMPARTMENTATION EFFECTS, UNSCHEDULED DNA-SYNTHESIS, AND VIRAL REPLICATION IN RESTING CELLS

  ARNER ESJ; FLYGAR M; BOHMAN C; WALLSTROM B; ERIKSSON S
• Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1984;774(1):26-34

  MAXIMAL FLUX RESPONSES AFTER MULTIPLE CHALLENGES WITH VASOPRESSIN

  RUBIN MS; KING CF; WEISSMAN JD; GERSHATOR D; ARNER E; MASUR SK
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