Molekylär kartläggning av nervsystemet vid hälsa och sjukdom – Jan Mulders grupp

Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2024;78:54-63

Substance P, NPY, CCK and their receptors in five brain regions in major depressive disorder with transcriptomic analysis of locus coeruleus neurons.

Barde S; Aguila J; Zhong W; Solarz A; Mei I; Prud'homme J; Palkovits M; Turecki G; Mulder J; Uhlén M; Nagy C; Mechawar N; Hedlund E; Hökfelt T

Article: EUROPEAN JOURNAL OF NEUROLOGY. 2023;30(10):3142-3148

Myoclonus in patients with COVID-19: Findings of autoantibodies against brain structures in cerebrospinal fluid.

Lindqvist I; Cunningham JL; Mulder J; Feresiadou A; Rostami E; Virhammar J; Kumlien E

Article: CELL. 2023;186(17):3726-3743.e24

Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex.

Chen A; Sun Y; Lei Y; Li C; Liao S; Meng J; Bai Y; Liu Z; Liang Z; Zhu Z; Yuan N; Yang H; Wu Z; Lin F; Wang K; Li M; Zhang S; Yang M; Fei T; Zhuang Z; Huang Y; Zhang Y; Xu Y; Cui L; Zhang R; Han L; Sun X; Chen B; Li W; Huangfu B; Ma K; Ma J; Li Z; Lin Y; Wang H; Zhong Y; Zhang H; Yu Q; Wang Y; Liu X; Peng J; Liu C; Chen W; Pan W; An Y; Xia S; Lu Y; Wang M; Song X; Liu S; Wang Z; Gong C; Huang X; Yuan Y; Zhao Y; Chai Q; Tan X; Liu J; Zheng M; Li S; Huang Y; Hong Y; Huang Z; Li M; Jin M; Li Y; Zhang H; Sun S; Gao L; Bai Y; Cheng M; Hu G; Liu S; Wang B; Xiang B; Li S; Li H; Chen M; Wang S; Li M; Liu W; Liu X; Zhao Q; Lisby M; Wang J; Fang J; Lin Y; Xie Q; Liu Z; He J; Xu H; Huang W; Mulder J; Yang H; Sun Y; Uhlen M; Poo M; Wang J; Yao J; Wei W; Li Y; Shen Z; Liu L; Liu Z; Xu X; Li C

Article: SCIENTIFIC REPORTS. 2022;12(1):21817

A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging.

Kovács T; Szinyákovics J; Billes V; Murányi G; Varga VB; Bjelik A; Légrádi Á; Szabó M; Sándor S; Kubinyi E; Szekeres-Paracky C; Szocsics P; Lőke J; Mulder J; Gulyás B; Renner É; Palkovits M; Gulya K; Maglóczky Z; Vellai T

Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6748

Author Correction: Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level.

Wang F; Ding P; Liang X; Ding X; Brandt CB; Sjöstedt E; Zhu J; Bolund S; Zhang L; de Rooij LPMH; Luo L; Wei Y; Zhao W; Lv Z; Haskó J; Li R; Qin Q; Jia Y; Wu W; Yuan Y; Pu M; Wang H; Wu A; Xie L; Liu P; Chen F; Herold J; Kalucka J; Karlsson M; Zhang X; Helmig RB; Fagerberg L; Lindskog C; Pontén F; Uhlen M; Bolund L; Jessen N; Jiang H; Xu X; Yang H; Carmeliet P; Mulder J; Chen D; Lin L; Luo Y

Article: ACTA NEUROPATHOLOGICA. 2022;144(4):651-676

Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging.

Gilvesy A; Husen E; Magloczky Z; Mihaly O; Hortobágyi T; Kanatani S; Heinsen H; Renier N; Hökfelt T; Mulder J; Uhlen M; Kovacs GG; Adori C

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(33):e2123146119

The neuropeptide landscape of human prefrontal cortex.

Zhong W; Barde S; Mitsios N; Adori C; Oksvold P; Feilitzen KV; O'Leary L; Csiba L; Hortobágyi T; Szocsics P; Mechawar N; Maglóczky Z; Renner É; Palkovits M; Uhlén M; Mulder J; Hökfelt T

Article: NATURE COMMUNICATIONS. 2022;13(1):3620

Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level.

Wang F; Ding P; Liang X; Ding X; Brandt CB; Sjöstedt E; Zhu J; Bolund S; Zhang L; de Rooij LPMH; Luo L; Wei Y; Zhao W; Lv Z; Haskó J; Li R; Qin Q; Jia Y; Wu W; Yuan Y; Pu M; Wang H; Wu A; Xie L; Liu P; Chen F; Herold J; Kalucka J; Karlsson M; Zhang X; Helmig RB; Fagerberg L; Lindskog C; Pontén F; Uhlen M; Bolund L; Jessen N; Jiang H; Xu X; Yang H; Carmeliet P; Mulder J; Chen D; Lin L; Luo Y

Article: CELL. 2022;185(10):1777-1792.e21

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays.

Chen A; Liao S; Cheng M; Ma K; Wu L; Lai Y; Qiu X; Yang J; Xu J; Hao S; Wang X; Lu H; Chen X; Liu X; Huang X; Li Z; Hong Y; Jiang Y; Peng J; Liu S; Shen M; Liu C; Li Q; Yuan Y; Wei X; Zheng H; Feng W; Wang Z; Liu Y; Wang Z; Yang Y; Xiang H; Han L; Qin B; Guo P; Lai G; Muñoz-Cánoves P; Maxwell PH; Thiery JP; Wu Q-F; Zhao F; Chen B; Li M; Dai X; Wang S; Kuang H; Hui J; Wang L; Fei J-F; Wang O; Wei X; Lu H; Wang B; Liu S; Gu Y; Ni M; Zhang W; Mu F; Yin Y; Yang H; Lisby M; Cornall RJ; Mulder J; Uhlén M; Esteban MA; Li Y; Liu L; Xu X; Wang J

Article: NATURE. 2022;604(7907):723-731

Cell transcriptomic atlas of the non-human primate Macaca fascicularis.

Han L; Wei X; Liu C; Volpe G; Zhuang Z; Zou X; Wang Z; Pan T; Yuan Y; Zhang X; Fan P; Guo P; Lai Y; Lei Y; Liu X; Yu F; Shangguan S; Lai G; Deng Q; Liu Y; Wu L; Shi Q; Yu H; Huang Y; Cheng M; Xu J; Liu Y; Wang M; Wang C; Zhang Y; Xie D; Yang Y; Yu Y; Zheng H; Wei Y; Huang F; Lei J; Huang W; Zhu Z; Lu H; Wang B; Wei X; Chen F; Yang T; Du W; Chen J; Xu S; An J; Ward C; Wang Z; Pei Z; Wong C-W; Liu X; Zhang H; Liu M; Qin B; Schambach A; Isern J; Feng L; Liu Y; Guo X; Liu Z; Sun Q; Maxwell PH; Barker N; Muñoz-Cánoves P; Gu Y; Mulder J; Uhlen M; Tan T; Liu S; Yang H; Wang J; Hou Y; Xu X; Esteban MA; Liu L

Article: BMC BIOLOGY. 2022;20(1):25

Genome-wide annotation of protein-coding genes in pig.

Karlsson M; Sjöstedt E; Oksvold P; Sivertsson Å; Huang J; Álvez MB; Arif M; Li X; Lin L; Yu J; Ma T; Xu F; Han P; Jiang H; Mardinoglu A; Zhang C; von Feilitzen K; Xu X; Wang J; Yang H; Bolund L; Zhong W; Fagerberg L; Lindskog C; Pontén F; Mulder J; Luo Y; Uhlen M

Article: NPJ PRECISION ONCOLOGY. 2021;5(1):97

FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation.

Gultekin O; Gonzalez-Molina J; Hardell E; Moyano-Galceran L; Mitsios N; Mulder J; Kokaraki G; Isaksson A; Sarhan D; Lehti K; Carlson JW

Article: SCIENCE ADVANCES. 2021;7(31):eabh2169

A single-cell type transcriptomics map of human tissues.

Karlsson M; Zhang C; Méar L; Zhong W; Digre A; Katona B; Sjöstedt E; Butler L; Odeberg J; Dusart P; Edfors F; Oksvold P; von Feilitzen K; Zwahlen M; Arif M; Altay O; Li X; Ozcan M; Mardinoglu A; Fagerberg L; Mulder J; Luo Y; Ponten F; Uhlén M; Lindskog C

Article: SCIENCE ADVANCES. 2021;7(30):eabg5733

Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.

Adori C; Daraio T; Kuiper R; Barde S; Horvathova L; Yoshitake T; Ihnatko R; Valladolid-Acebes I; Vercruysse P; Wellendorf AM; Gramignoli R; Bozoky B; Kehr J; Theodorsson E; Cancelas JA; Mravec B; Jorns C; Ellis E; Mulder J; Uhlén M; Bark C; Hökfelt T

Article: KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY. 2021;29(7):2228-2236

Increased levels of inflammatory markers in the subscapularis tendon and joint capsule in patients with subacromial impingement.

Farfaras S; Roshani L; Mulder J; Mitsios N; Hallström EK; Kartus J-T

Article: COMMUNICATIONS BIOLOGY. 2021;4(1):717

A porcine brain-wide RNA editing landscape.

Huang J; Lin L; Dong Z; Yang L; Zheng T; Gu W; Zhang Y; Yin T; Sjöstedt E; Mulder J; Uhlén M; Kristiansen K; Bolund L; Luo Y

Editorial comment: AMERICAN JOURNAL OF PSYCHIATRY. 2021;178(6):485-489

Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19.

Mulder J; Feresiadou A; Fällmar D; Frithiof R; Virhammar J; Rasmusson A; Rostami E; Kumlien E; Cunningham JL

Letter: BRAIN BEHAVIOR AND IMMUNITY. 2021;94:473-474

Indirect immunofluorescence for detecting anti-neuronal autoimmunity in CSF after COVID-19 - Possibilities and pitfalls.

Mulder J; Lindqvist I; Rasmusson AJ; Husén E; Rönnelid J; Kumlien E; Rostami E; Virhammar J; Cunningham JL

Article: ACTA NEUROPATHOLOGICA. 2021;141(5):681-696

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease.

Gerrits E; Brouwer N; Kooistra SM; Woodbury ME; Vermeiren Y; Lambourne M; Mulder J; Kummer M; Möller T; Biber K; Dunnen WFAD; De Deyn PP; Eggen BJL; Boddeke EWGM

Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2021;41(3):617-629

The cellular basis of increased PET hypoxia tracer uptake in focal cerebral ischemia with comparison between [18F]FMISO and [64Cu]CuATSM.

Little PV; Arnberg F; Jussing E; Lu L; Ingemann Jensen A; Mitsios N; Mulder J; Tran TA; Holmin S

Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):401

Exploring autoantibody signatures in brain tissue from patients with severe mental illness.

Just D; Månberg A; Mitsios N; Stockmeier CA; Rajkowska G; Uhlén M; Mulder J; Feuk L; Cunningham JL; Nilsson P; Carlström EL

Review: ESMO OPEN. 2020;5(4):e000856

Combinations in the first-line treatment of patients with advanced/metastatic renal cell cancer: regulatory aspects.

Moscetti L; Hennik P; Bolstad B; Camarero J; Josephson F; Melchiorri D; Sommerfelt Grønvold M; Sjoberg J; Botezatu M; Mulder J; Meulendijks D; Trullas Jimeno A; Zafiropoulos N; Bergh J; Enzmann H; Pignatti F

Article: JOURNAL OF NEUROSCIENCE METHODS. 2020;339:108708

A manual multiplex immunofluorescence method for investigating neurodegenerative diseases.

Ehrenberg AJ; Morales DO; Piergies AMH; Li SH; Tejedor JS; Mladinov M; Mulder J; Grinberg LT

Article: SCIENCE. 2020;367(6482):1090

An atlas of the protein-coding genes in the human, pig, and mouse brain.

Sjöstedt E; Zhong W; Fagerberg L; Karlsson M; Mitsios N; Adori C; Oksvold P; Edfors F; Limiszewska A; Hikmet F; Huang J; Du Y; Lin L; Dong Z; Yang L; Liu X; Jiang H; Xu X; Wang J; Yang H; Bolund L; Mardinoglu A; Zhang C; von Feilitzen K; Lindskog C; Pontén F; Luo Y; Hökfelt T; Uhlén M; Mulder J

Article: SCIENTIFIC REPORTS. 2020;10(1):1880

Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury.

Lyu C; Lyu G-W; Mulder J; Uhlén M; Cai X-H; Hökfelt T; Sten Shi T-J

Article: EMBO JOURNAL. 2020;39(1):e100882

Life-long impairment of glucose homeostasis upon prenatal exposure to psychostimulants.

Korchynska S; Krassnitzer M; Malenczyk K; Prasad RB; Tretiakov EO; Rehman S; Cinquina V; Gernedl V; Farlik M; Petersen J; Hannes S; Schachenhofer J; Reisinger SN; Zambon A; Asplund O; Artner I; Keimpema E; Lubec G; Mulder J; Bock C; Pollak DD; Romanov RA; Pifl C; Groop L; Hökfelt TG; Harkany T

Article: JOURNAL OF PAIN RESEARCH. 2020;13:419-429

G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury.

Lyu C; Lyu G-W; Mulder J; Martinez A; Shi T-JS

Article: SCIENCE. 2019;366(6472):eaax9198

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.

Uhlen M; Karlsson MJ; Zhong W; Tebani A; Pou C; Mikes J; Lakshmikanth T; Forsström B; Edfors F; Odeberg J; Mardinoglu A; Zhang C; von Feilitzen K; Mulder J; Sjöstedt E; Hober A; Oksvold P; Zwahlen M; Ponten F; Lindskog C; Sivertsson Å; Fagerberg L; Brodin P

Article: SCIENCE SIGNALING. 2019;12(609):eaaz0274

The human secretome.

Uhlén M; Karlsson MJ; Hober A; Svensson A-S; Scheffel J; Kotol D; Zhong W; Tebani A; Strandberg L; Edfors F; Sjöstedt E; Mulder J; Mardinoglu A; Berling A; Ekblad S; Dannemeyer M; Kanje S; Rockberg J; Lundqvist M; Malm M; Volk A-L; Nilsson P; Månberg A; Dodig-Crnkovic T; Pin E; Zwahlen M; Oksvold P; von Feilitzen K; Häussler RS; Hong M-G; Lindskog C; Ponten F; Katona B; Vuu J; Lindström E; Nielsen J; Robinson J; Ayoglu B; Mahdessian D; Sullivan D; Thul P; Danielsson F; Stadler C; Lundberg E; Bergström G; Gummesson A; Voldborg BG; Tegel H; Hober S; Forsström B; Schwenk JM; Fagerberg L; Sivertsson Å

Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995

Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.

Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Wärnberg F; Östman A

Article: BRAIN RESEARCH. 2019;1711:140-145

In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [18F]MNI-659.

Svedberg MM; Varnäs K; Varrone A; Mitsios N; Mulder J; Gulyás B; Beaumont V; Munoz-Sanjuan I; Zaleska MM; Schmidt CJ; Halldin C; Mrzljak L

Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2018;293(48):18477-18493

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.

Strakova K; Kowalski-Jahn M; Gybel T; Valnohova J; Dhople VM; Harnos J; Bernatik O; Ganji RS; Zdrahal Z; Mulder J; Lindskog C; Bryja V; Schulte G

Article: CEREBRAL CORTEX. 2018;28(9):3129-3142

Neuronal Expression of Opioid Gene is Controlled by Dual Epigenetic and Transcriptional Mechanism in Human Brain.

Bazov I; Sarkisyan D; Kononenko O; Watanabe H; Taqi MM; Stålhandske L; Verbeek DS; Mulder J; Rajkowska G; Sheedy D; Kril J; Sun X; Syvänen A-C; Yakovleva T; Bakalkin G

Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(9):3757-3768

Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity.

Zhang M-D; Su J; Adori C; Cinquina V; Malenczyk K; Girach F; Peng C; Ernfors P; Löw P; Borgius L; Kiehn O; Watanabe M; Uhlén M; Mitsios N; Mulder J; Harkany T; Hökfelt T

Article: EPILEPSIA. 2018;59(8):1507-1517

The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue.

Weidner LD; Kannan P; Mitsios N; Kang SJ; Hall MD; Theodore WH; Innis RB; Mulder J

Letter: ACTA NEUROPATHOLOGICA. 2017;134(4):675-677

A specific antibody to detect transcription factor T-Pit: a reliable marker of corticotroph cell differentiation and a tool to improve the classification of pituitary neuroendocrine tumours.

Sjöstedt E; Bollerslev J; Mulder J; Lindskog C; Pontén F; Casar-Borota O

Article: EMBO JOURNAL. 2017;36(14):2107-2125

A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.

Malenczyk K; Girach F; Szodorai E; Storm P; Segerstolpe Å; Tortoriello G; Schnell R; Mulder J; Romanov RA; Borók E; Piscitelli F; Di Marzo V; Szabó G; Sandberg R; Kubicek S; Lubec G; Hökfelt T; Wagner L; Groop L; Harkany T

Article: CEREBRAL CORTEX. 2017;27(6):3360-3377

Injury Leads to the Appearance of Cells with Characteristics of Both Microglia and Astrocytes in Mouse and Human Brain.

Wilhelmsson U; Andersson D; de Pablo Y; Pekny R; Ståhlberg A; Mulder J; Mitsios N; Hortobágyi T; Pekny M; Pekna M

Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2017;37(6):2062-2075

An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.

Kannan P; Schain M; Kretzschmar WW; Weidner L; Mitsios N; Gulyás B; Blom H; Gottesman MM; Innis RB; Hall MD; Mulder J

Article: SCIENCE. 2017;356(6340):eaal3321

A subcellular map of the human proteome.

Thul PJ; Åkesson L; Wiking M; Mahdessian D; Geladaki A; Ait Blal H; Alm T; Asplund A; Björk L; Breckels LM; Bäckström A; Danielsson F; Fagerberg L; Fall J; Gatto L; Gnann C; Hober S; Hjelmare M; Johansson F; Lee S; Lindskog C; Mulder J; Mulvey CM; Nilsson P; Oksvold P; Rockberg J; Schutten R; Schwenk JM; Sivertsson Å; Sjöstedt E; Skogs M; Stadler C; Sullivan DP; Tegel H; Winsnes C; Zhang C; Zwahlen M; Mardinoglu A; Pontén F; von Feilitzen K; Lilley KS; Uhlén M; Lundberg E

Article: CELLULAR SIGNALLING. 2017;32:93-103

FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis.

Hot B; Valnohova J; Arthofer E; Simon K; Shin J; Uhlén M; Kostenis E; Mulder J; Schulte G

Article: NUCLEAR MEDICINE AND BIOLOGY. 2017;46:50-53

Development of [11C]/[3H]THK-5351 - A potential novel carbon-11 tau imaging PET radioligand.

Stepanov V; Svedberg M; Jia Z; Krasikova R; Lemoine L; Okamura N; Furumoto S; Mitsios N; Mulder J; Långström B; Nordberg A; Halldin C

Article: NATURE NEUROSCIENCE. 2017;20(2):176-188

Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.

Romanov RA; Zeisel A; Bakker J; Girach F; Hellysaz A; Tomer R; Alpár A; Mulder J; Clotman F; Keimpema E; Hsueh B; Crow AK; Martens H; Schwindling C; Calvigioni D; Bains JS; Máté Z; Szabó G; Yanagawa Y; Zhang M-D; Rendeiro A; Farlik M; Uhlén M; Wulff P; Bock C; Broberger C; Deisseroth K; Hökfelt T; Linnarsson S; Horvath TL; Harkany T

Article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2017;1861(2):246-255

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain.

Kononenko O; Bazov I; Watanabe H; Gerashchenko G; Dyachok O; Verbeek DS; Alkass K; Druid H; Andersson M; Mulder J; Svenningsen ÅF; Rajkowska G; Stockmeier CA; Krishtal O; Yakovleva T; Bakalkin G

Article: PROTEOMICS CLINICAL APPLICATIONS. 2016;10(12):1242-1253

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.

Remnestål J; Just D; Mitsios N; Fredolini C; Mulder J; Schwenk JM; Uhlén M; Kultima K; Ingelsson M; Kilander L; Lannfelt L; Svenningsson P; Nellgård B; Zetterberg H; Blennow K; Nilsson P; Häggmark-Månberg A

Article: PROTEOMICS. 2016;16(22):2911-2920

Mass spectrometric analysis of synaptosomal membrane preparations for the determination of brain receptors, transporters and channels.

Sialana FJ; Gulyassy P; Májek P; Sjöstedt E; Kis V; Müller AC; Rudashevskaya EL; Mulder J; Bennett KL; Lubec G

Corrigendum: BRAIN STRUCTURE & FUNCTION. 2016;221(7):3843

Erratum to: Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord.

Zhang M-D; Barde S; Szodorai E; Josephson A; Mitsios N; Watanabe M; Attems J; Lubec G; Kovács GG; Uhlén M; Mulder J; Harkany T; Hökfelt T

Article: BRAIN STRUCTURE & FUNCTION. 2016;221(7):3803-3823

Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord.

Zhang M-D; Barde S; Szodorai E; Josephson A; Mitsios N; Watanabe M; Attems J; Lubec G; Kovács GG; Uhlén M; Mulder J; Harkany T; Hökfelt T

Article: ONCOTARGET. 2016;7(27):41948-41958

Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer.

Mezheyeuski A; Bradic Lindh M; Guren TK; Dragomir A; Pfeiffer P; Kure EH; Ikdahl T; Skovlund E; Corvigno S; Strell C; Pietras K; Ponten F; Mulder J; Qvortrup C; Portyanko A; Tveit KM; Glimelius B; Sorbye H; Östman A

Article: SCIENCE. 2016;353(6294):78-82

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.

Ståhl PL; Salmén F; Vickovic S; Lundmark A; Navarro JF; Magnusson J; Giacomello S; Asp M; Westholm JO; Huss M; Mollbrink A; Linnarsson S; Codeluppi S; Borg Å; Pontén F; Costea PI; Sahlén P; Mulder J; Bergmann O; Lundeberg J; Frisén J

Article: BRAIN STRUCTURE & FUNCTION. 2016;221(3):1279-1290

Acute neuroinflammation in a clinically relevant focal cortical ischemic stroke model in rat: longitudinal positron emission tomography and immunofluorescent tracking.

Tóth M; Little P; Arnberg F; Häggkvist J; Mulder J; Halldin C; Gulyás B; Holmin S

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(8):2188-2193

Anoctamin 2 identified as an autoimmune target in multiple sclerosis.

Ayoglu B; Mitsios N; Kockum I; Khademi M; Zandian A; Sjöberg R; Forsström B; Bredenberg J; Lima Bomfim I; Holmgren E; Grönlund H; Guerreiro-Cacais AO; Abdelmagid N; Uhlén M; Waterboer T; Alfredsson L; Mulder J; Schwenk JM; Olsson T; Nilsson P

Article: DRUG METABOLISM AND DISPOSITION. 2016;44(2):275-282

Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.

Weidner LD; Fung KL; Kannan P; Moen JK; Kumar JS; Mulder J; Innis RB; Gottesman MM; Hall MD

Article: FRONTIERS IN NEUROLOGY. 2016;7:23

Lesion Size Is Exacerbated in Hypoxic Rats Whereas Hypoxia-Inducible Factor-1 Alpha and Vascular Endothelial Growth Factor Increase in Injured Normoxic Rats: A Prospective Cohort Study of Secondary Hypoxia in Focal Traumatic Brain Injury.

Thelin EP; Frostell A; Mulder J; Mitsios N; Damberg P; Aski SN; Risling M; Svensson M; Morganti-Kossmann MC; Bellander B-M

Article: EXPERIMENTAL CELL RESEARCH. 2015;339(2):280-288

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes.

Dijksterhuis JP; Arthofer E; Marinescu VD; Nelander S; Uhlén M; Pontén F; Mulder J; Schulte G

Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2015;354(3):384-393

The Inhibitor Ko143 Is Not Specific for ABCG2.

Weidner LD; Zoghbi SS; Lu S; Shukla S; Ambudkar SV; Pike VW; Mulder J; Gottesman MM; Innis RB; Hall MD

Article: MOLECULAR PAIN. 2015;11:44

G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.

Lyu C; Mulder J; Barde S; Sahlholm K; Zeberg H; Nilsson J; Århem P; Hökfelt T; Fried K; Shi T-JS

Article: ACTA NEUROPATHOLOGICA. 2015;129(4):541-563

Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease.

Ádori C; Glück L; Barde S; Yoshitake T; Kovacs GG; Mulder J; Maglóczky Z; Havas L; Bölcskei K; Mitsios N; Uhlén M; Szolcsányi J; Kehr J; Rönnbäck A; Schwartz T; Rehfeld JF; Harkany T; Palkovits M; Schulz S; Hökfelt T

Article: STROKE. 2015;46(3):835-842

Imaging of a clinically relevant stroke model: glucose hypermetabolism revisited.

Arnberg F; Grafström J; Lundberg J; Nikkhou-Aski S; Little P; Damberg P; Mitsios N; Mulder J; Lu L; Söderman M; Stone-Elander S; Holmin S

Article: SCIENCE. 2015;347(6220):1260419

Proteomics. Tissue-based map of the human proteome.

Uhlén M; Fagerberg L; Hallström BM; Lindskog C; Oksvold P; Mardinoglu A; Sivertsson Å; Kampf C; Sjöstedt E; Asplund A; Olsson I; Edlund K; Lundberg E; Navani S; Szigyarto CA-K; Odeberg J; Djureinovic D; Takanen JO; Hober S; Alm T; Edqvist P-H; Berling H; Tegel H; Mulder J; Rockberg J; Nilsson P; Schwenk JM; Hamsten M; von Feilitzen K; Forsberg M; Persson L; Johansson F; Zwahlen M; von Heijne G; Nielsen J; Pontén F

Article: EMBO JOURNAL. 2015;34(1):36-54

A secretagogin locus of the mammalian hypothalamus controls stress hormone release.

Romanov RA; Alpár A; Zhang M-D; Zeisel A; Calas A; Landry M; Fuszard M; Shirran SL; Schnell R; Dobolyi Á; Oláh M; Spence L; Mulder J; Martens H; Palkovits M; Uhlen M; Sitte HH; Botting CH; Wagner L; Linnarsson S; Hökfelt T; Harkany T

Article: PLOS ONE. 2015;10(6):e0130028

Defining the Human Brain Proteome Using Transcriptomics and Antibody-Based Profiling with a Focus on the Cerebral Cortex.

Sjöstedt E; Fagerberg L; Hallström BM; Häggmark A; Mitsios N; Nilsson P; Pontén F; Hökfelt T; Uhlén M; Mulder J

Article: CEREBRAL CORTEX. 2014;24(12):3277-3288

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.

Keimpema E; Zheng K; Barde SS; Berghuis P; Dobszay MB; Schnell R; Mulder J; Luiten PGM; Xu ZD; Runesson J; Langel Ü; Lu B; Hökfelt T; Harkany T

Article: EJNMMI RESEARCH. 2014;4(1):34

Evaluation of efficacy of a new MEK inhibitor, RO4987655, in human tumor xenografts by [(18)F] FDG-PET imaging combined with proteomic approaches.

Tegnebratt T; Ruge E; Bader S; Ishii N; Aida S; Yoshimura Y; Ooi C-H; Lu L; Mitsios N; Meresse V; Mulder J; Pawlak M; Venturi M; Tessier J; Stone-Elander S

Article: JOURNAL OF PROTEOME RESEARCH. 2014;13(11):4607-4619

Affinity proteomic profiling of plasma, cerebrospinal fluid, and brain tissue within multiple sclerosis.

Byström S; Ayoglu B; Häggmark A; Mitsios N; Hong M-G; Drobin K; Forsström B; Fredolini C; Khademi M; Amor S; Uhlén M; Olsson T; Mulder J; Nilsson P; Schwenk JM

Article: EJNMMI RESEARCH. 2014;4(1):17

Visualization of angiogenesis during cancer development in the polyoma middle T breast cancer model: molecular imaging with (R)-[11C]PAQ.

Samén E; Lu L; Mulder J; Thorell J-O; Damberg P; Tegnebratt T; Holmgren L; Rundqvist H; Stone-Elander S

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(12):E1149-E1158

Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury.

Zhang M-D; Tortoriello G; Hsueh B; Tomer R; Ye L; Mitsios N; Borgius L; Grant G; Kiehn O; Watanabe M; Uhlén M; Mulder J; Deisseroth K; Harkany T; Hökfelt TGM

Article: CIRCULATION-HEART FAILURE. 2014;7(2):359-366

Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support.

Liem DA; Nsair A; Setty SP; Cadeiras M; Wang D; Maclellan R; Lotz C; Lin AJ; Tabaraki J; Li H; Ge J; Odeberg J; Ponten F; Larson E; Mulder J; Lundberg E; Weiss JN; Uhlen M; Ping P; Deng MC

Article: MOLECULAR & CELLULAR PROTEOMICS. 2014;13(2):397-406

Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

Fagerberg L; Hallström BM; Oksvold P; Kampf C; Djureinovic D; Odeberg J; Habuka M; Tahmasebpoor S; Danielsson A; Edlund K; Asplund A; Sjöstedt E; Lundberg E; Szigyarto CA-K; Skogs M; Takanen JO; Berling H; Tegel H; Mulder J; Nilsson P; Schwenk JM; Lindskog C; Danielsson F; Mardinoglu A; Sivertsson A; von Feilitzen K; Forsberg M; Zwahlen M; Olsson I; Navani S; Huss M; Nielsen J; Ponten F; Uhlén M

Article: JOURNAL OF PROTEOME RESEARCH. 2013;12(6):2439-2448

Contribution of antibody-based protein profiling to the human Chromosome-centric Proteome Project (C-HPP).

Fagerberg L; Oksvold P; Skogs M; Algenäs C; Lundberg E; Pontén F; Sivertsson A; Odeberg J; Klevebring D; Kampf C; Asplund A; Sjöstedt E; Al-Khalili Szigyarto C; Edqvist P-H; Olsson I; Rydberg U; Hudson P; Ottosson Takanen J; Berling H; Björling L; Tegel H; Rockberg J; Nilsson P; Navani S; Jirström K; Mulder J; Schwenk JM; Zwahlen M; Hober S; Forsberg M; von Feilitzen K; Uhlén M

Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2013;304(8):R675-R682

Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent fashion after renal denervation in rats.

Mulder J; Hökfelt T; Knuepfer MM; Kopp UC

Article: MOLECULAR PAIN. 2012;8:80

Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.

Shi T-JS; Xiang Q; Zhang M-D; Tortoriello G; Hammarberg H; Mulder J; Fried K; Wagner L; Josephson A; Uhlén M; Harkany T; Hökfelt T

Review: CELLULAR SIGNALLING. 2012;24(2):378-387

The renaissance of Ca2+-binding proteins in the nervous system: secretagogin takes center stage.

Alpár A; Attems J; Mulder J; Hökfelt T; Harkany T

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(44):18108-18113

Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse.

Lindfors C; Nilsson IAK; Garcia-Roves PM; Zuberi AR; Karimi M; Donahue LR; Roopenian DC; Mulder J; Uhlén M; Ekström TJ; Davisson MT; Hökfelt TGM; Schalling M; Johansen JE

Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2011;519(7):1219-1257

Characterization of NPY Y2 receptor protein expression in the mouse brain. II. Coexistence with NPY, the Y1 receptor, and other neurotransmitter-related molecules.

Stanić D; Mulder J; Watanabe M; Hökfelt T

Article: BRAIN. 2011;134(Pt 4):1041-1060

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease.

Mulder J; Zilberter M; Pasquaré SJ; Alpár A; Schulte G; Ferreira SG; Köfalvi A; Martín-Moreno AM; Keimpema E; Tanila H; Watanabe M; Mackie K; Hortobágyi T; de Ceballos ML; Harkany T

Article: GLIA. 2011;59(1):119-131

WNT signaling in activated microglia is proinflammatory.

Halleskog C; Mulder J; Dahlström J; Mackie K; Hortobágyi T; Tanila H; Kumar Puli L; Färber K; Harkany T; Schulte G

Article: SCIENCE SIGNALING. 2010;3(131):ra54

Increased abundance of opioid receptor heteromers after chronic morphine administration.

Gupta A; Mulder J; Gomes I; Rozenfeld R; Bushlin I; Ong E; Lim M; Maillet E; Junek M; Cahill CM; Harkany T; Devi LA

Published conference paper: EUROPEAN JOURNAL OF NEUROSCIENCE. 2010;31(12):2166-2177

Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon.

Mulder J; Spence L; Tortoriello G; Dinieri JA; Uhlén M; Shui B; Kotlikoff MI; Yanagawa Y; Aujard F; Hökfelt T; Hurd YL; Harkany T

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22492-22497

Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons.

Mulder J; Zilberter M; Spence L; Tortoriello G; Uhlén M; Yanagawa Y; Aujard F; Hökfelt T; Harkany T

Article: JOURNAL OF NEUROCHEMISTRY. 2009;110(4):1330-1338

GABA action in immature neocortical neurons directly depends on the availability of ketone bodies.

Rheims S; Holmgren CD; Chazal G; Mulder J; Harkany T; Zilberter T; Zilberter Y

Review: CHEMBIOCHEM. 2009;10(10):1591-1598

The polarised life of the endocannabinoid system in CNS development.

Anavi-Goffer S; Mulder J

Article: MOLECULAR & CELLULAR PROTEOMICS. 2009;8(7):1612-1622

Tissue profiling of the mammalian central nervous system using human antibody-based proteomics.

Mulder J; Björling E; Jonasson K; Wernérus H; Hober S; Hökfelt T; Uhlén M

Review: JOURNAL OF COMPARATIVE NEUROLOGY. 2009;513(1):1-20

Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems.

Fetissov SO; Bensing S; Mulder J; Le Maitre E; Hulting A-L; Harkany T; Ekwall O; Sköldberg F; Husebye ES; Perheentupa J; Rorsman F; Kämpe O; Hökfelt T

Article: BIOLOGICAL SIGNALS. 2009;17(3):203-212

Expression of p-Akt in sensory neurons and spinal cord after peripheral nerve injury.

Shi T-JS; Huang P; Mulder J; Ceccatelli S; Hokfelt T

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(25):8760-8765

Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning.

Mulder J; Aguado T; Keimpema E; Barabás K; Ballester Rosado CJ; Nguyen L; Monory K; Marsicano G; Di Marzo V; Hurd YL; Guillemot F; Mackie K; Lutz B; Guzmán M; Lu H-C; Galve-Roperh I; Harkany T

Published conference paper: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2008;286(1-2 Suppl 1):S84-S90

Endocannabinoid functions controlling neuronal specification during brain development.

Harkany T; Keimpema E; Barabás K; Mulder J

Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2007;293(4):R1561-R1572

Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of alpha1- and alpha2-adrenoceptors on renal sensory nerve fibers.

Kopp UC; Cicha MZ; Smith LA; Mulder J; Hökfelt T

Article: MOLECULAR ENDOCRINOLOGY. 2007;21(7):1685-1698

GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.

Egerod KL; Holst B; Petersen PS; Hansen JB; Mulder J; Hökfelt T; Schwartz TW

Article: NEUROSCIENCE. 2007;146(4):1689-1703

Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system.

Mulder J; Wernérus H; Shi T-J; Pontén F; Hober S; Uhlén M; Hökfelt T

Article: SCIENCE. 2007;316(5828):1212-1216

Hardwiring the brain: endocannabinoids shape neuronal connectivity.

Berghuis P; Rajnicek AM; Morozov YM; Ross RA; Mulder J; Urbán GM; Monory K; Marsicano G; Matteoli M; Canty A; Irving AJ; Katona I; Yanagawa Y; Rakic P; Lutz B; Mackie K; Harkany T

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(3):949-954

Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1.

Bensing S; Fetissov SO; Mulder J; Perheentupa J; Gustafsson J; Husebye ES; Oscarson M; Ekwall O; Crock PA; Hökfelt T; Hulting A-L; Kämpe O

Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2006;23(4):1063-1070

Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra.

Martín-Ibañez R; Jenstad M; Berghuis P; Edwards RH; Hioki H; Kaneko T; Mulder J; Canals JM; Ernfors P; Chaudhry FA; Harkany T

Article: BRAIN RESEARCH BULLETIN. 2005;67(1-2):117-125

Input from the medial septum regulates adult hippocampal neurogenesis.

Van der Borght K; Mulder J; Keijser JN; Eggen BJL; Luiten PGM; Van der Zee EA

Article: BEHAVIOURAL BRAIN RESEARCH. 2005;163(1):33-41

Galantamine-induced behavioral recovery after sublethal excitotoxic lesions to the rat medial septum.

Mulder J; Harkany T; Czollner K; Cremers TIFH; Keijser JN; Nyakas C; Luiten PGM

Article: AMINO ACIDS. 2005;28(4):377-387

Regional distribution of biogenic amines, amino acids and cholinergic markers in the CNS of the C57BL/6 strain.

Van Dam D; Marescau B; Cremers T; Mulder J; Engelborghs S; De Deyn PP

Article: NEUROCHEMISTRY INTERNATIONAL. 2005;46(5):409-422

Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models.

Van Dam D; Marescau B; Engelborghs S; Cremers T; Mulder J; Staufenbiel M; De Deyn PP

Article: DEVELOPMENTAL NEUROBIOLOGY. 2004;60(4):463-472

Neonatal handling increases sensitivity to acute neurodegeneration in adult rats.

Horvath KM; Harkany T; Mulder J; Koolhaas JM; Luiten PGM; Meerlo P

Article: JOURNAL OF NEUROENDOCRINOLOGY. 2003;15(5):498-507

Chronic excess of corticosterone increases serotonergic fibre degeneration in aged rats.

Nyakas C; Mulder J; Felszeghy K; Keijser JN; Mehra R; Luiten PGM

Article: NEUROREPORT. 2002;13(6):767-772

Distinct subsets of nucleus basalis neurons exhibit similar sensitivity to excitotoxicity.

Harkany T; Varga C; Grosche J; Mulder J; Luiten PGM; Hortobágyi T; Penke B; Härtig W

Article: NEUROSCIENCE. 2002;110(3):489-504

17beta-estradiol enhances cortical cholinergic innervation and preserves synaptic density following excitotoxic lesions to the rat nucleus basalis magnocellularis.

Horvath KM; Hårtig W; Van der Veen R; Keijser JN; Mulder J; Ziegert M; Van der Zee EA; Harkany T; Luiten PGM

Article: NEUROREPORT. 2001;12(17):3767-3772

Cortical cholinergic decline parallels the progression of Borna virus encephalitis.

Gies U; Görcs TJ; Mulder J; Planz O; Stitz L; Bilzer T; Luiten PG; Harkany T

Article: NEUROSCIENCE. 2001;108(4):629-642

Oral post-lesion administration of 5-HT(1A) receptor agonist repinotan hydrochloride (BAY x 3702) attenuates NMDA-induced delayed neuronal death in rat magnocellular nucleus basalis.

Harkany T; Mulder J; Horvath KM; Keijser J; van der Meeberg EK; Nyakas C; Luiten PG

Article: NEUROSCIENCE. 2001;108(4):611-627

Short-term consequences of N-methyl-D-aspartate excitotoxicity in rat magnocellular nucleus basalis: effects on in vivo labelling of cholinergic neurons.

Harkany T; Grosche J; Mulder J; Horvath KM; Keijser J; Hortobágyi T; Luiten PG; Härtig W

Article: NEUROBIOLOGY OF DISEASE. 1999;6(2):109-121

N-Methyl-D-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neurons against beta-amyloid neurotoxicity.

Harkany T; Mulder J; Sasvári M; Abrahám I; Kónya C; Zarándi M; Penke B; Luiten PG; Nyakas C

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