Jiri Barteks grupp

Article: NEURO-ONCOLOGY. 2023;25(6):1058-1072

Small molecule-mediated disruption of ribosome biogenesis synergizes with FGFR inhibitors to suppress glioma cell growth.

Zisi A; Kanellis DC; Moussaud S; Karlsson I; Carén H; Bräutigam L; Bartek J; Lindström MS

Article: SCIENCE ADVANCES. 2021;7(32):eabf7561

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output.

Kanellis DC; Espinoza JA; Zisi A; Sakkas E; Bartkova J; Katsori A-M; Boström J; Dyrskjøt L; Broholm H; Altun M; Elsässer SJ; Lindström MS; Bartek J

Article: GENES & DEVELOPMENT. 2020;34(15-16):1065-1074

Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution.

Björkman A; Johansen SL; Lin L; Schertzer M; Kanellis DC; Katsori A-M; Christensen ST; Luo Y; Andersen JS; Elsässer SJ; Londono-Vallejo A; Bartek J; Schou KB

Article: CELL DEATH AND DIFFERENTIATION. 2020;27(2):773-789

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity.

Espinoza JA; Zisi A; Kanellis DC; Carreras-Puigvert J; Henriksson M; Hühn D; Watanabe K; Helleday T; Lindström MS; Bartek J

Article: CANCER RESEARCH. 2018;78(20):5901-5916

Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype.

Goudarzi KM; Espinoza JA; Guo M; Bartek J; Nistér M; Lindström MS; Hägerstrand D

Article: NATURE. 2017;552(7684):194-199

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.

Skrott Z; Mistrik M; Andersen KK; Friis S; Majera D; Gursky J; Ozdian T; Bartkova J; Turi Z; Moudry P; Kraus M; Michalova M; Vaclavkova J; Dzubak P; Vrobel I; Pouckova P; Sedlacek J; Miklovicova A; Kutt A; Li J; Mattova J; Driessen C; Dou QP; Olsen J; Hajduch M; Cvek B; Deshaies RJ; Bartek J

Article: NATURE CELL BIOLOGY. 2016;18(7):777-789

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Galanos P; Vougas K; Walter D; Polyzos A; Maya-Mendoza A; Haagensen EJ; Kokkalis A; Roumelioti F-M; Gagos S; Tzetis M; Canovas B; Igea A; Ahuja AK; Zellweger R; Havaki S; Kanavakis E; Kletsas D; Roninson IB; Garbis SD; Lopes M; Nebreda A; Thanos D; Blow JJ; Townsend P; Sørensen CS; Bartek J; Gorgoulis VG

Article: JOURNAL OF CELL BIOLOGY. 2016;212(3):281-288

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.

Moudry P; Watanabe K; Wolanin KM; Bartkova J; Wassing IE; Watanabe S; Strauss R; Troelsgaard Pedersen R; Oestergaard VH; Lisby M; Andújar-Sánchez M; Maya-Mendoza A; Esashi F; Lukas J; Bartek J

Article: CELL. 2015;162(1):146-159

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

Dietlein F; Kalb B; Jokic M; Noll EM; Strong A; Tharun L; Ozretić L; Künstlinger H; Kambartel K; Randerath WJ; Jüngst C; Schmitt A; Torgovnick A; Richters A; Rauh D; Siedek F; Persigehl T; Mauch C; Bartkova J; Bradley A; Sprick MR; Trumpp A; Rad R; Saur D; Bartek J; Wolf J; Büttner R; Thomas RK; Reinhardt HC

Article: NATURE. 2015;521(7553):541-544

REV7 counteracts DNA double-strand break resection and affects PARP inhibition.

Xu G; Chapman JR; Brandsma I; Yuan J; Mistrik M; Bouwman P; Bartkova J; Gogola E; Warmerdam D; Barazas M; Jaspers JE; Watanabe K; Pieterse M; Kersbergen A; Sol W; Celie PHN; Schouten PC; van den Broek B; Salman A; Nieuwland M; de Rink I; de Ronde J; Jalink K; Boulton SJ; Chen J; van Gent DC; Bartek J; Jonkers J; Borst P; Rottenberg S

Article: CELL. 2014;158(3):633-646

ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress.

Kumar A; Mazzanti M; Mistrik M; Kosar M; Beznoussenko GV; Mironov AA; Garrè M; Parazzoli D; Shivashankar GV; Scita G; Bartek J; Foiani M

Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2013;20(12):1425-1433

JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks.

Watanabe S; Watanabe K; Akimov V; Bartkova J; Blagoev B; Lukas J; Bartek J

Article: CELL. 2013;155(5):1088-1103

ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

Toledo LI; Altmeyer M; Rask M-B; Lukas C; Larsen DH; Povlsen LK; Bekker-Jensen S; Mailand N; Bartek J; Lukas J

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