Post-transkriptionell reglering i mitokondrier – Joanna Rorbachs grupp

Mitokondriell dysfunktion är en viktig bidragande orsak till metaboliska och neurodegenerativa sjukdomar, åldrande och cancer. Flera nyckelfaktorer som reglerar mitokondriernas genuttryck är förknippade med en rad olika sjukdomar hos människor. Målet med vår forskning är att bättre förstå de post-transkriptionella regleringsnätverk som kontrollerar genuttryck i mitokondrier.

En del av:

Institutionen för medicinsk biokemi och biofysik

Publikationer
Medarbetare och kontakt

Publikationer

Utvalda publikationer

Article: NATURE COMMUNICATIONS. 2025;16(1):4080
T cell toxicity induced by tigecycline binding to the mitochondrial ribosome
Shao Q; Khawaja A; Nguyen MD; Singh V; Zhang J; Liu Y; Nordin J; Adori M; Innis CA; Dopico XC; Rorbach J
Journal article: NUCLEIC ACIDS RESEARCH. 2024;52(16):9710-9726
The human mitochondrial translation factor TACO1 alleviates mitoribosome stalling at polyproline stretches
Brischigliaro M; Kruger A; Moran JC; Antonicka H; Ahn A; Shoubridge EA; Rorbach J; Barrientos A
Article: NATURE COMMUNICATIONS. 2024;15(1):5664
GTPBP8 plays a role in mitoribosome formation in human mitochondria
Cipullo M; Gese GV; Gopalakrishna S; Krueger A; Lobo V; Pirozhkova MA; Marks J; Palenikova P; Shiriaev D; Liu Y; Misic J; Cai Y; Nguyen MD; Abdelbagi A; Li X; Minczuk M; Hafner M; Benhalevy D; Sarshad AA; Atanassov I; Hallberg BM; Rorbach J
Article: JCI INSIGHT. 2023;8(17):e167656
Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations
Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
Article: NUCLEIC ACIDS RESEARCH. 2023;51(2):891-907
Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria
Remes C; Khawaja A; Pearce SF; Dinan AM; Gopalakrishna S; Cipullo M; Kyriakidis V; Zhang J; Dopico XC; Yukhnovets O; Atanassov I; Firth AE; Cooperman B; Rorbach J
Article: NATURE COMMUNICATIONS. 2023;14(1):30
Human mitochondria require mtRF1 for translation termination at non-canonical stop codons
Kruger A; Remes C; Shiriaev DI; Liu Y; Spahr H; Wibom R; Atanassov I; Nguyen MD; Cooperman BS; Rorbach J
Article: NATURE. 2022;606(7914):603-608
Mechanism of mitoribosomal small subunit biogenesis and preinitiation
Itoh Y; Khawaja A; Laptev I; Cipullo M; Atanassov I; Sergiev P; Rorbach J; Amunts A
Article: NATURE COMMUNICATIONS. 2021;12(1):3673
Structural basis for late maturation steps of the human mitoribosomal large subunit
Cipullo M; Gese GV; Khawaja A; Haellberg BM; Rorbach J
Article: NUCLEIC ACIDS RESEARCH. 2021;49(1):354-370
Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly
Cipullo M; Pearce SF; Sanchez IGL; Gopalakrishna S; Kruger A; Schober F; Busch JD; Li X; Wredenberg A; Atanassov I; Rorbach J
Article: NATURE COMMUNICATIONS. 2020;11(1):2932
Distinct pre-initiation steps in human mitochondrial translation
Khawaja A; Itoh Y; Remes C; Spahr H; Yukhnovets O; Hoefig H; Amunts A; Rorbach J

Medarbetare och kontakt

Gruppledare

Joanna Rorbach
Senior Forskare
E-postadress joanna.rorbach@ki.se

Alla medarbetare i gruppen

Sirui Chen
Forskningsassistent
E-postadress sirui.chen@ki.se
Shreekara Gopalakrishna
Postdoktor
E-postadress shreekara.gopalakrishna@ki.se
Anas Khawaja
Forskningsspecialist
E-postadress anas.khawaja@ki.se
Daria Kovalchuk
Doktorand, Marie Curie
E-postadress daria.kovalchuk@ki.se
Annika Krüger
Anknuten till Forskning
E-postadress annika.kruger@ki.se
Khac Huy Ngo
Anknuten till Forskning
E-postadress khac.huy.ngo@ki.se
Minh Duc Nguyen
Anknuten till Forskning
E-postadress minh.duc.nguyen@ki.se
Jakub Pagacz
Postdoktorala Studier
E-postadress jakub.pagacz@ki.se
Vlad-Julian Piljukov
Postdoktorala Studier
E-postadress vladjulian.piljukov@ki.se
Joanna Rorbach
Senior Forskare
E-postadress joanna.rorbach@ki.se
Qiuya Shao
Forskningsassistent
E-postadress qiuya.shao@ki.se
Shaghayegh Sheikh
Postdoktorala Studier
E-postadress shaghayegh.sheikh@ki.se
Dmitrii Igorevich Shiriaev
E-postadress dmitrii.shiriaev@ki.se
Vivek Singh
Postdoktor
E-postadress vivek.singh@ki.se
Julius Wilming
Forskningsassistent
E-postadress julius.wilming@ki.se

Besöksadress

Karolinska Institutet, Biomedicum 9D, floor 9, Solnavägen 9, Stockholm, 171 65, Sweden