Wilhelm lab

Vårt mål är att förstå de mekanismer som reglerar cancer och hur samspelet mellan tumörceller, den omgivande stödvävnaden (stroma) och infiltrerande immunceller styr tumörutvecklingen. Vi använder omprogrammeringstekniker för att skapa sjukdomsrelevanta stamcellsmodeller som efterliknar sjukdomen. På så sätt kan vi identifiera de mekanismer som gör att friska celler blir cancerceller och hitta nya mål för utveckling av framtida behandlingar.

En del av:

Institutionen för mikrobiologi, tumör- och cellbiologi

Publikationer
Medarbetare och kontakt

Publikationer

Utvalda publikationer

Article: NEURO-ONCOLOGY. 2025;27(3):779-794
Development of an orthotopic medulloblastoma zebrafish model for rapid drug testing
van Bree N; Oppelt A-S; Lindstroem S; Zhou L; Boutin L; Coyle B; Swartling FJ; Johnsen JI; Braeutigam L; Wilhelm M
Preprint: BIORXIV. 2024
EphA2 and Phosphoantigen-Mediated Selective Killing of Medulloblastoma by γδT Cells Preserves Neuronal and Stem Cell Integrity
Boutin L; Liu M; Merville JD; Bedoya-Reina O; Wilhelm M
Article: NEURO-ONCOLOGY. 2024;26(9):1685-1699
High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in sonic hedgehog-medulloblastoma
Zhou L; van Bree N; Boutin L; Ryu J; Moussaud S; Liu M; Otrocka M; Olsson M; Falk A; Wilhelm M
Preprint: BIORXIV. 2024
High-throughput neural stem cell-based drug screening identifies S6K1 inhibition as a selective vulnerability in SHH-medulloblastoma
Zhou L; van Bree N; Boutin L; Moussaud S; Otrocka M; Falk A; Wilhelm M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(10):e2017089118
TAp73 represses NF-κB-mediated recruitment of tumor-associated macrophages in breast cancer
Wolfsberger J; Sakil HAM; Zhou L; van Bree N; Baldisseri E; Ferreira SDS; Zubillaga V; Stantic M; Fritz N; Hartman J; Rolny C; Wilhelm MT
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(33):20127-20138
Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells
Susanto E; Navarro AM; Zhou L; Sundstrom A; van Bree N; Stantic M; Moslem M; Tailor J; Rietdijk J; Zubillaga V; Huebner J-M; Weishaupt H; Wolfsberger J; Alafuzoff I; Nordgren A; Magnaldo T; Siesjo P; Johnsen JI; Kool M; Tammimies K; Darabi A; Swartling FJ; Falk A; Wilhelm M
Article: CELL DEATH & DISEASE. 2020;11(1):52
p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids
Navarro AM; Pronk RJ; van der Geest AT; Oliynyk G; Nordgren A; Arsenian-Henriksson M; Falk A; Wilhelm M
Article: STEM CELL RESEARCH. 2019;34:101356
Generation of induced pluripotent stem cell lines from two Neuroblastoma patients carrying a germline ALK R1275Q mutation
Navarro AM; Day K; Kogner P; Wilhelm M; Falk A
Article: ONCOGENE. 2018;37(27):3729-3739
ΔNp73 enhances HIF-1α protein stability through repression of the ECV complex
Stantic M; Wolfsberger J; Sakil HAM; Wilhelm MT
Review: CELL DEATH DISCOVERY. 2018;4:7
Modeling cancer using patient-derived induced pluripotent stem cells to understand development of childhood malignancies
Navarro AM; Susanto E; Falk A; Wilhelm M
Article: CELLULAR ONCOLOGY. 2017;40(6):631-638
ΔNp73 regulates the expression of the multidrug-resistance genes ABCB1 and ABCB5 in breast cancer and melanoma cells - a short report
Sakil HAM; Stantic M; Wolfsberger J; Brage SE; Hansson J; Wilhelm MT
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(1):220-225
TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity
Stantic M; Sakil HAM; Zirath H; Fang T; Sanz G; Fernandez-Woodbridge A; Marin A; Susanto E; Mak TW; Henriksson MA; Wilhelm MT

Medarbetare och kontakt

Gruppledare

Margareta Wilhelm
Professor
Telefon +46852482823
E-postadress margareta.wilhelm@ki.se

Alla medarbetare i gruppen

Mercè Baulenas Farrés
Postdoktorala Studier
E-postadress merce.baulenas.farres@ki.se
Gunnar Bjursell
Anknuten till Forskning
Telefon +46852486645
E-postadress gunnar.k.bjursell@ki.se
Benedek Bozoky
Anknuten till Forskning
E-postadress benedek.bozoky@ki.se
Suhas Darekar
Senior Forskningsspecialist
E-postadress suhas.darekar@ki.se
Eskil Degsell
Anknuten till Forskning
E-postadress eskil.degsell@ki.se
Barbro Ehlin Henriksson
Annan Grund
E-postadress barbro.ehlin.henriksson@ki.se
Ingemar Ernberg
Professor, Senior
E-postadress ingemar.ernberg@ki.se
Konstantinos Fragkoulis
Doktorand
E-postadress konstantinos.fragkoulis@ki.se
Maureen Fredriks
Doktorand
E-postadress maureen.fredriks@ki.se
Margaux Viviane Marie Gaborieau
Doktorand
E-postadress margaux.gaborieau@ki.se
Tara Hessa
Anknuten till Forskning
E-postadress tara.hessa@ki.se
Sonia Lain
Professor Emeritus
E-postadress sonia.lain@ki.se
Barbara Lasut-Szyszka
Postdoktorala Studier
E-postadress barbara.lasutszyszka@ki.se
Kaisa Lehti
Forskare
Telefon +46852485254
E-postadress kaisa.lehti@ki.se
Mingzhi Liu
Doktorand
E-postadress mingzhi.liu@ki.se
Manon Louazon
Annan Grund
E-postadress manon.louazon@ki.se
Michele Masucci
Anknuten till Forskning | Doktorand
E-postadress michele.masucci@ki.se
Mridini Prashant Mehta
Anknuten till Forskning
E-postadress mridini.prashant.mehta@ki.se
Muhammad Mushtaq
Anknuten till Forskning
E-postadress muhammad.mushtaq@ki.se
Roland Möllby
Professor Emeritus
Telefon +46852487175
E-postadress roland.mollby@ki.se
Ann-Sophie Oppelt
Doktorand
E-postadress annsophie.oppelt@ki.se
Iurii Petrov
Postdoktorala Studier
E-postadress iurii.petrov@ki.se
Sylvain Peuget
Forskningsspecialist
E-postadress sylvain.peuget@ki.se
Ivanna Prylutska
Postdoktorala Studier
E-postadress ivanna.prylutska@ki.se
Eric Scarfone
Anknuten till Forskning
E-postadress eric.scarfone@ki.se
Galina Selivanova
Professor, Senior
Telefon +46852486302
E-postadress galina.selivanova@ki.se
Victoria Valvo
Postdoktorala Studier
E-postadress victoria.valvo@ki.se
Yiming Xia
Doktorand
E-postadress yiming.xia@ki.se