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Ninib Baryawno forskargrupp

Stöd forskning inom Institutionen för Kvinnor och barns hälsa

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Publikationer

Alla gruppmedlemmars publikationer

Article: CANCER LETTERS. 2025;625:217769
Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progression
Milosevic J; Fransson S; Svensson J; Otte J; Olsen TK; Sveinbjornsson B; Hertwig F; Bartenhagen C; Abel F; Reinsbach SE; Djos A; Javanmardi N; Shi Y; Hehir-Kwa JY; Mensenkamp A; Tytgat GAM; Holmberg J; Molenaar JJ; Jongmans M; Fischer M; Baryawno N; Gisselsson D; Martinsson T; Kogner P; Johnsen JI
Article: MOLECULAR CANCER RESEARCH. 2025;23(7):653-665
Single-Cell and Spatial Transcriptomics Reveal a Tumor-Associated Macrophage Subpopulation that Mediates Prostate Cancer Progression and Metastasis
Mei S; Zhang H; Hirz T; Jeffries NE; Xu Y; Baryawno N; Wu S; Wu C-L; Patnaik A; Saylor PJ; Sykes DB; Dahl DM
Article: PLOS ONE. 2025;20(4):e0321020
Solute carrier family 2 member 2 (glucose transporter 2): a common factor of hepatocyte and hepatocellular carcinoma differentiation
Kim Y; Yeuni Y; Heo HJ; Kim ES; Myung K; Baryawno N; Kim YH; Oh C-K
Doctoral thesis: 2025
Delineating cellular heterogeneity of neuroblastoma for identifying therapeutically targetable vulnerabilities
Embaie BT
Article: CANCER RESEARCH. 2025;85(6):1015-1034
Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State
Embaie BT; Sarkar H; Alchahin AM; Otte J; Olsen TK; Tummler C; Kameneva P; Artemov AV; Akkuratova N; Adameyko I; Stukenborg J-B; Wickstrom M; Kogner P; Johnsen JI; Mei S; Kharchenko PV; Baryawno N
Doctoral thesis: 2025
Characterization of the immune cell landscape in neuroblastoma : for the discovery of novel therapeutics
Verhoeven M
Article: PLOS ONE. 2025;20(1):e0315981
Uncovering NK cell sabotage in gut diseases via single cell transcriptomics
Lee H; Ko DS; Heo HJ; Baek SE; Kim EK; Kwon EJ; Kang J; Yu Y; Baryawno N; Kim K; Lee D; Kim YH
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2024;741:151075
ERRα is dispensable for hematopoietic stem cell function in the bone marrow
Bae HE; Baryawno N; Kim BS; Yoon S; Oh S-O; Jo E-K; Kim CD; Lee D
Article: CANCERS. 2024;16(24):4162
DHODH Inhibition Suppresses MYC and Inhibits the Growth of Medulloblastoma in a Novel In Vivo Zebrafish Model
Tsea I; Olsen TK; Polychronopoulos PA; Tummler C; Sykes DB; Baryawno N; Dyberg C
Journal article: NEURO-ONCOLOGY ADVANCES. 2024;6(1):vdae172
Genomic tumor evolution dictates human medulloblastoma progression
Ruchiy Y; Tsea I; Preka E; Verhoeven BM; Olsen TK; Mei S; Sinha I; Blomgren K; Carlson L-M; Dyberg C; Johnsen JI; Baryawno N
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(19):10517
27-Hydroxycholesterol Negatively Affects the Function of Bone Marrow Endothelial Cells in the Bone Marrow
Woo S-Y; Shim W-S; Lee H; Baryawno N; Song P; Kim BS; Yoon S; Oh S-O; Lee D
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(19):10381
Blockade of mTORC1 via Rapamycin Suppresses 27-Hydroxycholestrol-Induced Inflammatory Responses
Kang N; Kim J; Kwon M; Son Y; Eo S-K; Baryawno N; Kim BS; Yoon S; Oh S-O; Lee D; Kim K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2024;134(21):e175310
Epigenetic regulation of cell state by H2AFY governs immunogenicity in high-risk neuroblastoma
Nagarajan D; Parracho RT; Corujo D; Xie M; Kutkaite G; Olsen TK; Bedos MR; Salehi M; Baryawno N; Menden MP; Chen X; Buschbeck M; Mao Y
Journal article: CANCER RESEARCH. 2024;84(17):b060
Clonal composition of αβ and γδ T cells in primary human neuroblastoma tumors - Is every child unique?
Verhoeven BM; Ye K; Stenman J; Kogner P; Johnsen JI; Reina OB; Kreslavskiy T; Baryawno N
Article: CANCER RESEARCH COMMUNICATIONS. 2024;4(9):2553-2564
Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis
Ek T; Ibrahim RR; Vogt H; Georgantzi K; Trager C; Gaarder J; Djos A; Rahmqvist I; Mellstroem E; Pujol-Calderon F; Vannas C; Hansson L; Fagman H; Treis D; Fransson S; Osterlund T; Chuang T-P; Verhoeven BM; Stahlberg A; Palmer RH; Hallberg B; Martinsson T; Kogner P; Dalin M
Article: MOLECULAR CANCER. 2024;23(1):180
Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma
Olsen TK; Otte J; Mei S; Embaie BT; Kameneva P; Cheng H; Gao T; Zachariadis V; Tsea I; Bjorklund A; Kryukov E; Hou Z; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Fard SS; Johnsen JI; Kogner P; Adameyko I; Enge M; Kharchenko PV; Baryawno N
Article: JCI INSIGHT. 2024;9(6):e173337
Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic
Mei S; Alchahin AM; Embaie BT; Gavriliuc IM; Verhoeven BM; Zhao T; Li X; Jeffries NE; Pepich A; Sarkar H; Olsen TK; Wickstrom M; Stenman J; Reina-Bedoya O; Kharchenko PV; Saylor PJ; Johnsen JI; Sykes DB; Kogner P; Baryawno N
Article: CANCER CELL. 2024;42(2):283-300.e8
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy
Wienke J; Visser LL; Kholosy WM; Keller KM; Barisa M; Poon E; Munnings-Tomes S; Himsworth C; Calton E; Rodriguez A; Bernardi R; Ham FVD; Hooff SRV; Matser YAH; Tas ML; Langenberg KPS; Lijnzaad P; Borst AL; Zappa E; Bergsma FJ; Strijker JGM; Verhoeven BM; Mei S; Kramdi A; Restuadi R; Sanchez-Bernabeu A; Cornel AM; Holstege FCP; Gray JC; Tytgat GAM; Scheijde-Vermeulen MA; Wijnen MHWA; Dierselhuis MP; Straathof K; Behjati S; Wu W; Heck AJR; Koster J; Nierkens S; Janoueix-Lerosey I; Krijger RRD; Baryawno N; Chesler L; Anderson J; Caron HN; Margaritis T; Noesel MMV; Molenaar JJ
Article: JOURNAL OF NUCLEAR MEDICINE. 2024;65(2):294-299
Noninvasive PET Detection of CD69-Positive Immune Cells Before Signs of Clinical Disease in Inflammatory Arthritis
Puuvuori E; Shen Y; Hulsart-Billstrom G; Mitran B; Zhang B; Cheung P; Wegrzyniak O; Ingvast S; Persson J; Stahl S; Korsgren O; Lofblom J; Wermeling F; Eriksson O
Article: GENOME MEDICINE. 2024;16(1):1
Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions
Mei S; Alchahin AM; Tsea I; Kfoury Y; Hirz T; Jeffries NE; Zhao T; Xu Y; Zhang H; Sarkar H; Wu S; Subtelny AO; Johnsen JI; Zhang Y; Salari K; Wu C-L; Randolph MA; Scadden DT; Dahl DM; Shin J; Kharchenko PV; Saylor PJ; Sykes DB; Baryawno N
Article: NEURO-ONCOLOGY ADVANCES. 2024;6(1):vdae172
Genomic tumor evolution dictates human medulloblastoma progression.
Ruchiy Y; Tsea I; Preka E; Verhoeven BM; Olsen TK; Mei S; Sinha I; Blomgren K; Carlson L-M; Dyberg C; Johnsen JI; Baryawno N
Article: ONCOIMMUNOLOGY. 2023;12(1):2184130
Macrophage infiltration promotes regrowth in MYCN-amplified neuroblastoma after chemotherapy
Valind A; Verhoeven BM; Enoksson J; Karlsson J; Christensson G; Manas A; Aaltonen K; Jansson C; Bexell D; Baryawno N; Gisselsson D; Hagerling C
Review: CANCERS. 2023;15(19):4734
Recent Advances in Single-Cell RNA-Sequencing of Primary and Metastatic Clear Cell Renal Cell Carcinoma
Alchahin AM; Tsea I; Baryawno N
Article: JCI INSIGHT. 2023;8(17):e167858
Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo.
Massengale M; Massengale JL; Benson CR; Baryawno N; Oki T; Steinhauser ML; Wang A; Balani D; Oh LS; Randolph MA; Gill TJ; Kronenberg HM; Scadden DT
Article: JOURNAL OF NUCLEAR MEDICINE. 2023;64(3):423-429
PET Imaging of Neutrophil Elastase with 11C-GW457427 in Acute Respiratory Distress Syndrome in Pigs
Puuvuori E; Chiodaroli E; Estrada S; Cheung P; Lubenow N; Sigfridsson J; Romelin H; Ingvast S; Elgland M; Liggieri F; Korsgren O; Perchiazzi G; Eriksson O; Antoni G
Article: NATURE COMMUNICATIONS. 2023;14(1):663
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses
Hirz T; Mei S; Sarkar H; Kfoury Y; Wu S; Verhoeven BM; Subtelny AO; Zlatev DV; Wszolek MW; Salari K; Murray E; Chen F; Macosko EZ; Wu C-L; Scadden DT; Dahl DM; Baryawno N; Saylor PJ; Kharchenko PV; Sykes DB
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S211-S212
SINGLE CELL ANALYSIS OF HUMAN BONE METASTATIC NEUROBLASTOMA UNRAVELS EMERGING IMMUNE CELL POPULATIONS IN THE BONE MARROW
Alchahin A; Embaie BT; Mei S; Verhoeven BM; Olsen T; Kharchenko P; Johnsen JI; Kogner P; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S215
SINGLE-CELL TRANSCRIPTOMICS REVEAL TUMOR CELL DIVERSITY IN NEUROBLASTOMA TRANSGENIC MOUSE AND ORGANOID MODELS
Embaie BT; Sarkar H; Alchahin A; Otte J; Olsen T; Mei S; Kharchenko P; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S226
SCHWANN CELL PRECURSORS IS THE CELL-OF-ORIGIN IN HUMAN NEUROBLASTOMA
Otte J; Olsen T; Mei S; Kameneva P; Embaie BT; Bjorklund A; Johansson A; Sundstrom E; Martinsson T; Fransson S; Stenman J; Cheng H; Zachariadis V; Enge M; Johnsen JI; Kogner P; Adameyko I; Kharchenko P; Baryawno N
Conference publication: PEDIATRIC BLOOD & CANCER. 2022;69:S229-S230
INVESTIGATING THE INTERACTIONS OF DISTINCT TUMOR SUBPOPULATIONS IN HUMAN NEUROBLASTOMA USING SINGLE-CELL RNASEQ AND NOVEL SPATIAL MULTI-OMICS
Tsea I; Olsen T; Otte J; Mei S; Embaie BT; Kogner P; Johnsen JI; Baryawno N; Fard S
Article: CELL DEATH & DISEASE. 2022;13(10):916
Role of reactive oxygen species in regulating 27-hydroxycholesterol-induced apoptosis of hematopoietic progenitor cells and myeloid cell lines
Woo S-Y; Lee H; Park SM; Choi H-S; Kim J; Kwon M; Sohn J; Nam JH; Kim H-S; Song P; Baryawno N; Kim Y-H; Kim K; Lee D
Article: NATURE COMMUNICATIONS. 2022;13(1):5747
A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma
Alchahin AM; Mei S; Tsea I; Hirz T; Kfoury Y; Dahl D; Wu C-L; Subtelny AO; Wu S; Scadden DT; Shin JH; Saylor PJ; Sykes DB; Kharchenko PV; Baryawno N
Book chapter: NANOTECHNOLOGY FOR DIABETES MANAGEMENT. 2022;p. 262-291
In Vivo Imaging of the Pancreas and Gut Hormone Receptors
Eriksson O; Hulsart-Billström G; Mitran B; Puuvuori E; Velikyan I
Article: JCI INSIGHT. 2022;7(17):e153836
DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma
Olsen TK; Dyberg C; Embaie BT; Alchahin A; Milosevic J; Ding J; Otte J; Tummler C; Myrberg IH; Westerhout EM; Koster J; Versteeg R; Ding H-F; Kogner P; Johnsen JI; Sykes DB; Baryawno N
Preprint: BIORXIV. 2022
A new transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma
Alchahin AM; Mei S; Tsea I; Hirz T; Kfoury Y; Dahl D; Wu C-L; Subtelny AO; Wu S; Scadden DT; Shin JH; Saylor PJ; Sykes DB; Kharchenko PV; Baryawno N
Article: CELL REPORTS MEDICINE. 2022;3(6):100657
The immune cell atlas of human neuroblastoma
Verhoeven BM; Mei S; Olsen TK; Gustafsson K; Valind A; Lindstrom A; Gisselsson D; Fard SS; Hagerling C; Kharchenko PV; Kogner P; Johnsen JI; Baryawno N
Conference publication: CANCER RESEARCH. 2022;82(12)
Single-cell landscape of the TH-MYCN neuroblastoma mouse model
Embaie BT; Alchahin A; Olsen TK; Sarkar H; Mei S; Baryawno N
Conference publication: CANCER RESEARCH. 2022;82(12)
Transcriptomic landscape of medulloblastoma reveals pathways of tumor-stroma remodelling
Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
Journal article: CANCER RESEARCH. 2022;82(12_Supplement):1677
Abstract 1677: Transcriptomic landscape of medulloblastoma reveals pathways of tumor-stroma remodelling
Tsea I; Ruchiy Y; Verhoeven M; Sinha I; Blomgren K; Carlson LM; Johnsen JI; Dyberg C; Baryawno N
Article: SCIENTIFIC REPORTS. 2022;12(1):7519
Oxime derivative TFOBO promotes cell death by modulating reactive oxygen species and regulating NADPH oxidase activity in myeloid leukemia
Jo A; Kwak J-H; Woo S-Y; Kim B-Y; Son Y; Choi H-S; Kim J; Kwon M; Cho H-R; Eo S-K; Nam JH; Kim H-S; Baryawno N; Lee D; Kim K
Journal article: EJNMMI RESEARCH. 2022;12(1):19
PET-CT imaging of pulmonary inflammation using [⁶⁸Ga]Ga-DOTA-TATE
Puuvuori E; Liggieri F; Velikyan I; Chiodaroli E; Sigfridsson J; Romelin H; Ingvast S; Korsgren O; Hulsart-Billstrom G; Perchiazzi G; Eriksson O
Article: AMERICAN JOURNAL OF CANCER RESEARCH. 2022;12(12):5532-5551
Original Risk stratification of patients with right-sided colorectal cancer based on the tumor-infiltrating M1 macrophage
Lim DM; Kang J; Woo S-Y; Choi H-S; Kwon M; Kim J; Park HR; Jung K; Baryawno N; Kim H-S; Lee D; Kim YH
Journal article: SCIENTIFIC REPORTS. 2021;11(1):24466
Potential of [¹¹C]UCB-J as a PET tracer for islets of Langerhans
Puuvuori E; Rokka J; Carlsson P-O; Li Z; Eriksson J; Eriksson O
Article: ELIFE. 2021;10:e66512
External signals regulate continuous transcriptional states in hematopoietic stem cells
Fast EM; Sporrij A; Manning M; Rocha EL; Yang S; Zhou Y; Guo J; Baryawno N; Barkas N; Scadden D; Camargo F; Zon LI
Article: CANCER CELL. 2021;39(11):1464-1478.e8
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment
Kfoury Y; Baryawno N; Severe N; Mei S; Gustafsson K; Hirz T; Brouse T; Scadden EW; Igolkina AA; Kokkaliaris K; Choi BD; Barkas N; Randolph MA; Shin JH; Saylor PJ; Scadden DT; Sykes DB; Kharchenko PV
Conference publication: PEDIATRIC BLOOD & CANCER. 2021;68:S224-S225
Single-Cell Transcriptomic Landscape of Transgenic Mouse Model of Neuroblastoma
Embaie BT; Alchahin A; Olsen T; Mei S; Gavriliuc I; Baryawno N
Article: CANCERS. 2021;13(21):5493
High Expression of PPM1D Induces Tumors Phenotypically Similar to TP53 Loss-of-Function Mutations in Mice
Milosevic J; Fransson S; Gulyas M; Olsen TK; Gallo-Oller G; Treis D; Elfman LHM; Wilhelm M; Martinsson T; Baryawno N; Kogner P; Johnsen JI
Journal article: SCIENTIFIC REPORTS. 2021;11(1):19151
Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69
Persson J; Puuvuori E; Zhang B; Velikyan I; Aberg O; Muller M; Nygren P-A; Stahl S; Korsgren O; Eriksson O; Lofblom J
Article: NATURE METHODS. 2021;18(8):912-920
An unsupervised method for physical cell interaction profiling of complex tissues
Andrews N; Serviss JT; Geyer N; Andersson AB; Dzwonkowska E; Sutevski I; Heijboer R; Baryawno N; Gerling M; Enge M
Article: NATURE GENETICS. 2021;53(5):694-706
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin
Kameneva P; Artemov AV; Kastriti ME; Faure L; Olsen TK; Otte J; Erickson A; Semsch B; Andersson ER; Ratz M; Frisen J; Tischler AS; de Krijger RR; Bouderlique T; Akkuratova N; Vorontsova M; Gusev O; Fried K; Sundstrom E; Mei S; Kogner P; Baryawno N; Kharchenko PV; Adameyko I
Article: BIOMEDICINES. 2021;9(4):434
PET Imaging of GPR44 by Antagonist [¹¹C]MK-7246 in Pigs
Cheung P; Zhang B; Puuvuori E; Estrada S; Amin MA; Ye S; Korsgren O; Odell LR; Eriksson J; Eriksson O
Journal article: BMJ OPEN DIABETES RESEARCH & CARE. 2021;9(1):e002083
Exploring the GLP-1-GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography
Manell E; Puuvuori E; Svensson A; Velikyan I; Hulsart-Billstrom G; Hedenqvist P; Holst JJ; Waern MJ; Eriksson O
Review: FRONTIERS IN ONCOLOGY. 2021;10:624079
MYCN Function in Neuroblastoma Development
Otte J; Dyberg C; Pepich A; Johnsen JI
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(49):31386-31397
Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways
Sender V; Hentrich K; Pathak A; Ler ATQ; Embaie BT; Lundstrom SL; Gaetani M; Bergstrand J; Nakamoto R; Sham L-T; Widengren J; Normark S; Henriques-Normark B
Article: CLINICAL CANCER RESEARCH. 2020;26(21):5747-5758
The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia.
Verbeke D; Demeyer S; Prieto C; de Bock CE; De Bie J; Gielen O; Jacobs K; Mentens N; Verhoeven BM; Uyttebroeck A; Boeckx N; De Keersmaecker K; Maertens J; Segers H; Cools J
Article: BLOOD. 2020;136(11):1303-1316
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Yusuf RZ; Saez B; Sharda A; van Gastel N; Yu VWC; Baryawno N; Scadden EW; Acharya S; Chattophadhyay S; Huang C; Viswanathan V; S'aulis D; Cobert J; Sykes DB; Keibler MA; Das S; Hutchinson JN; Churchill M; Mukherjee S; Lee D; Mercier F; Doench J; Bullinger L; Logan DJ; Schreiber S; Stephanopoulos G; Rizzo WB; Scadden DT
Article: CELL METABOLISM. 2020;32(3):391-403.e6
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance
van Gastel N; Spinelli JB; Sharda A; Schajnovitz A; Baryawno N; Rhee C; Oki T; Grace E; Soled HJ; Milosevic J; Sykes DB; Hsu PP; Vander Heiden MG; Vidoudez C; Trauger SA; Haigis MC; Scadden DT
Article: NATURE. 2020;579(7797):111-117
Lipid availability determines fate of skeletal progenitor cells via SOX9
van Gastel N; Stegen S; Eelen G; Schoors S; Carlier A; Daniels VW; Baryawno N; Przybylski D; Depypere M; Stiers P-J; Lambrechts D; Van Looveren R; Torrekens S; Sharda A; Agostinis P; Lambrechts D; Maes F; Swinnen JV; Geris L; Van Oosterwyck H; Thienpont B; Carmeliet P; Scadden DT; Carmeliet G
Article: SCIENTIFIC REPORTS. 2019;9(1):17365
FGF Signalling in the Self-Renewal of Colon Cancer Organoids.
Otte J; Dizdar L; Behrens B; Goering W; Knoefel WT; Wruck W; Stoecklein NH; Adjaye J
Article: CELL STEM CELL. 2019;25(4):570-583.e7
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping
Severe N; Karabacak NM; Gustafsson K; Baryawno N; Courties G; Kfoury Y; Kokkaliaris KD; Rhee C; Lee D; Scadden EW; Garcia-Robledo JE; Brouse T; Nahrendorf M; Toner M; Scadden DT
Article: CANCERS. 2019;11(9):E1371-1371
Bispecific GRPR-Antagonistic Anti-PSMA/GRPR Heterodimer for PET and SPECT Diagnostic Imaging of Prostate Cancer
Mitran B; Varasteh Z; Abouzayed A; Rinne SS; Puuvuori E; De Rosa M; Larhed M; Tolmachev V; Orlova A; Rosenstrom U
Article: CELL. 2019;177(7):1915-1932.e16
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia
Baryawno N; Przybylski D; Kowalczyk MS; Kfoury Y; Severe N; Gustafsson K; Kokkaliaris KD; Mercier F; Tabaka M; Hofree M; Dionne D; Papazian A; Lee D; Ashenberg O; Subramanian A; Vaishnav ED; Rozenblatt-Rosen O; Regev A; Scadden DT
Article: BRITISH JOURNAL OF DERMATOLOGY. 2019;180(5):1150-1160
Gene expression profiling in aggressive digital papillary adenocarcinoma sheds light on the architecture of a rare sweat gland carcinoma.
Surowy HM; Giesen AK; Otte J; Büttner R; Falkenstein D; Friedl H; Meier F; Petzsch P; Wachtmeister T; Westphal D; Wieczorek D; Wruck W; Adjaye J; Rütten A; Redler S
Article: STEM CELL RESEARCH & THERAPY. 2019;10(1):100
Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature.
Spitzhorn L-S; Megges M; Wruck W; Rahman MS; Otte J; Degistirici Ö; Meisel R; Sorg RV; Oreffo ROC; Adjaye J
Article: CANCER RESEARCH. 2018;78(18):5300-5314
Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer
Ubellacker JM; Baryawno N; Severe N; DeCristo MJ; Sceneay J; Hutchinson JN; Haider M-T; Rhee CS; Qin Y; Gregory WM; Garrido-Castro AC; Holen I; Brown JE; Coleman RE; Scadden DT; McAllister SS
Article: GENOME BIOLOGY. 2018;19(1):78
dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments
Petukhov V; Guo J; Baryawno N; Severe N; Scadden DT; Samsonova MG; Kharchenko PV
Journal article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(6):2651
Bone marrow drives central nervous system regeneration after radiation injury (vol 128, pg 281, 2018)
Dietrich J; Baryawno N; Nayyar N; Valtis YK; Yang B; Ly I; Besnard A; Severe N; Gustafsson KU; Andronesi OC; Batchelor TT; Sahay A; Scadden DT
Journal article: NEUROLOGY. 2018;90(15_supplement)
Bone Marrow is a Critical Mediator of Central Nervous System Regeneration after Radiation Injury (S23.003)
Dietrich J; Baryawno N; Nayyar N; Valtis Y; Yang B; Ly I; Besnard A; Severe N; Gustafsson K; Andronesi O; Batchelor T; Sahay A; Scadden D
Article: CURRENT PROTOCOLS IN MOLECULAR BIOLOGY. 2018;122(1):e57
Introduction to Single-Cell RNA Sequencing.
Olsen TK; Baryawno N
Article: CELL. 2018;172(1-2):191-204.e10
Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell
Hoggatt J; Singh P; Tate TA; Chou B-K; Datari SR; Fukuda S; Liu L; Kharchenko PV; Schajnovitz A; Baryawno N; Mercier FE; Boyer J; Gardner J; Morrow DM; Scadden DT; Pelus LM
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(1):281-293
Bone marrow drives central nervous system regeneration after radiation injury
Dietrich J; Baryawno N; Nayyar N; Valtis YK; Yang B; Ly I; Besnard A; Severe N; Gustafsson KU; Andronesi OC; Batchelor TT; Sahay A; Scadden DT
Article: SCIENCE. 2017;358(6367):eaal5081
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF^high neutrophils
Engblom C; Pfirschke C; Zilionis R; Martins JDS; Bos SA; Courties G; Rickelt S; Severe N; Baryawno N; Faget J; Savova V; Zemmour D; Kline J; Siwicki M; Garris C; Pucci F; Liao H-W; Lin Y-J; Newton A; Yaghi OK; Iwamoto Y; Tricot B; Wojtkiewicz GR; Nahrendorf M; Cortez-Retamozo V; Meylan E; Hynes RO; Demay M; Klein A; Bredella MA; Scadden DT; Weissleder R; Pittet MJ
Review: FEBS LETTERS. 2017;591(15):2226-2240
New insights into human primordial germ cells and early embryonic development from single-cell analysis.
Otte J; Wruck W; Adjaye J
Editorial comment: CELL STEM CELL. 2017;20(5):590-592
Hematopoiesis: Reconciling Historic Controversies about the Niche
Baryawno N; Severe N; Scadden DT
Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(4):1405-1413
Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells
Kalaitzidis D; Lee D; Efeyan A; Kfoury Y; Nayyar N; Sykes DB; Mercier FE; Papazian A; Baryawno N; Victora GD; Neuberg D; Sabatini DM; Scadden DT
Journal article: CELL. 2017;168(5):944-945
Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells (vol 167, pg 1310, 2016)
Yu VWC; Yusuf RZ; Oki T; Wu J; Saez B; Wang X; Cook C; Baryawno N; Ziller MJ; Lee E; Gu H; Meissner A; Lin CP; Kharchenko PV; Scadden DT
Journal article: BLOOD. 2016;128(22):430
Distinct Stress Responses of Bone Marrow Stromal Cell Subgroups Defined by Unbiased Single-Cell Mass-Cytometry Analysis
Severe N; Karabacak M; Baryawno N; Gustafsson K; Kfoury YS; Toner M; Scadden DT
Article: CELL. 2016;167(5):1310-1322.e17
Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells
Yu VWC; Yusuf RZ; Oki T; Wu J; Saez B; Wang X; Cook C; Baryawno N; Ziller MJ; Lee E; Gu H; Meissner A; Lin CP; Kharchenko PV; Scadden DT
Article: CELL STEM CELL. 2016;19(4):530-543
Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators
Silberstein L; Goncalves KA; Kharchenko PV; Turcotte R; Kfoury Y; Mercier F; Baryawno N; Severe N; Bachand J; Spencer JA; Papazian A; Lee D; Chitteti BR; Srour EF; Hoggatt J; Tate T; Lo Celso C; Ono N; Nutt S; Heino J; Sipila K; Shioda T; Osawa M; Lin CP; Hu G-F; Scadden DT
Article: MOLECULAR & CELLULAR ONCOLOGY. 2016;3(2):e1131356
Wingless/β-catenin signaling as a modulator of chemoresistance in cancer
Johnsen JI; Wickstrom M; Baryawno N
Article: NATURE COMMUNICATIONS. 2015;6:8904
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance
Wickstrom M; Dyberg C; Milosevic J; Einvik C; Calero R; Sveinbjornsson B; Sanden E; Darabi A; Siesjo P; Kool M; Kogner P; Baryawno N; Johnsen JI
Article: BMC GENOMICS. 2015;16:925
Combined ultra-low input mRNA and whole-genome sequencing of human embryonic stem cells.
Mertes F; Lichtner B; Kuhl H; Blattner M; Otte J; Wruck W; Timmermann B; Lehrach H; Adjaye J
Review: COCHRANE DATABASE OF SYSTEMATIC REVIEWS. 2015;2015(5):CD009863
Water infusion versus air insufflation for colonoscopy.
Hafner S; Zolk K; Radaelli F; Otte J; Rabenstein T; Zolk O
Journal article: CELL RESEARCH. 2014;24(10):1151-1152
Blood loses it when nerves go bad
Baryawno N; Scadden DT
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;450(4):1600-1605
Effects of epigenetic modificators in combination with small molecule inhibitors of receptor tyrosine kinases on medulloblastoma growth
Marino A-M; Frijhoff J; Calero R; Baryawno N; Ostman A; Johnsen JI
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(10):2351-2361
Frequent detection of human cytomegalovirus in neuroblastoma: A novel therapeutic target?
Wolmer-Solberg N; Baryawno N; Rahbar A; Fuchs D; Odeberg J; Taher C; Wilhelmi V; Milosevic J; Mohammad A-A; Martinsson T; Sveinbjornsson B; Johnsen JI; Kogner P; Soederberg-Naucler C
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;132(7):1516-1524
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo
Wickstrom M; Dyberg C; Shimokawa T; Milosevic J; Baryawno N; Fuskevag OM; Larsson R; Kogner P; Zaphiropoulos PG; Johnsen JI
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2013;42(4):1239-1248
Expression of TWEAK/Fn14 in neuroblastoma: Implications in tumorigenesis
Pettersen I; Baryawno N; Abel F; Bakkelund WH; Zykova SN; Winberg J-O; Moens U; Rasmuson A; Kogner P; Johnsen JI; Sveinbjornsson B
Article: ONCOTARGET. 2011;2(12):1329-1338
Is human cytomegalovirus a target in cancer therapy?
Johnsen JI; Baryawno N; Soderberg-Naucler C
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;129(12):2958-2965
Effects of small molecule inhibitors of PI3K/Akt/mTOR signaling on neuroblastoma growth in vitro and in vivo
Segerstrom L; Baryawno N; Sveinbjornsson B; Wickstrom M; Elfman L; Kogner P; Johnsen JI
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(10):4043-4055
Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target
Baryawno N; Rahbar A; Wolmer-Solberg N; Taher C; Odeberg J; Darabi A; Khan Z; Sveinbjornsson B; Fuskevag O-M; Segerstrom L; Nordenskjold M; Siesjo P; Kogner P; Johnsen JI; Soderberg-Naucler C
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):208-212
Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models
Marino A-M; Sofiadis A; Baryawno N; Johnsen JI; Larsson C; Vukojevic V; Ekstrom TJ
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;38(3):843-849
Differential forms of p53 in medulloblastoma primary tumors, cell lines and xenografts
Philipova T; Baryawno N; Hartmann W; Pietsch T; Drud H; Johnsen JI; Ekstrom TJ
Article: CELL CYCLE. 2010;9(13):2548-2554
Medulloblastoma A disease with disorganized developmental signaling cascades
Baryawno N; Sveinbjornsson B; Kogner P; Johnsen JI
Doctoral thesis: 2010
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
Baryawno N
Article: CANCER RESEARCH. 2010;70(1):266-276
Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
Baryawno N; Sveinbjornsson B; Eksborg S; Chen C-S; Kogner P; Johnsen JI
Article: FASEB JOURNAL. 2008;22(10):3525-3536
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
Sveinbjornsson B; Rasmuson A; Baryawno N; Wan M; Pettersen I; Ponthan F; Orrego A; Haeggstrom JZ; Johnsen JI; Kogner P
Article: NEURO-ONCOLOGY. 2008;10(5):661-674
Tumor-growth-promoting cyclooxygenase-2 prostaglandin E₂ pathway provides medulloblastoma therapeutic targets
Baryawno N; Sveinbjornsson B; Eksborg S; Orrego A; Segerstrom L; Oqvist CO; Holm S; Gustavsson B; Kagedal B; Kogner P; Johnsen JI
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