Angiogenes, cancer, metabola sjukdomar, hjärt-kärlsjukdom, ögonsjukdomar – Yihai Caos forskargrupp

Publikationer

Utvalda publikationer

• Article: GUT. 2025;:gutjnl-2024-334618

  Pericyte drives the formation of circulating tumour cell-neutrophil clusters to promote colorectal cancer metastasis

  Wang S; Ye G; Xu X; Lin Y; Li X; Zhang Z; Qi M; Tan L; Cheng M; Zhang H; Pan J; Lin C; Huang D; Deng R; Li X; Wang G; Qiu S; Chu X; Chen Y; Zeng H; Zhang J; Wang C; Shuai H; Shi C; Yuan X; Cao Y; Chen M; Huang M; Ye W; Zhang D
• Article: CELL METABOLISM. 2025;37(5):1075-1088.e7

  Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation

  Wu W; Sui W; Chen S; Guo Z; Jing X; Wang X; Wang Q; Yu X; Xiong W; Ji J; Yang L; Zhang Y; Jiang W; Yu G; Liu S; Tao W; Zhao C; Zhang Y; Chen Y; Zhang C; Cao Y
• Article: ADVANCED SCIENCE. 2024;11(48):e2409726

  Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AML

  Shao G; Wang X; Zheng Y; Ma J; Wang L; Yan Z; Sun Z; Zhang S; Wu H; Lv Y; Huang H; Li J; Zhu T; Yang B; Wang N; Chen T; Guo X; Jin Y; Kang J; Wang H; Cao Y; Fu C
• Article: CELL DISCOVERY. 2024;10(1):106

  NUMB dysfunction defines a novel mechanism underlying hyperuricemia and gout

  Chi J; Chen Y; Li C; Liu S; Che K; Kong Z; Guo Z; Chu Y; Huang Y; Yang L; Sun C; Wang Y; Lv W; Zhang Q; Guo H; Zhao H; Yang Z; Xu L; Wang P; Dong B; Hu J; Liu S; Wang F; Zhao Y; Qi M; Xin Y; Nan H; Zhao X; Zhang W; Xiao M; Si K; Wang Y; Cao Y
• Article: ADVANCED SCIENCE. 2024;11(38):e2402332

  Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues

  Chen R; Cheng T; Xie S; Sun X; Chen M; Zhao S; Ruan Q; Ni X; Rao M; Quan X; Chen K; Zhang S; Cheng T; Xu Y; Chen Y; Yang Y; Cao Y
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(6):e2305947121

  Effective treatment of optic neuropathies by intraocular delivery of MSC-sEVs through augmenting the G-CSF- macrophage pathway

  Yi W; Xue Y; Qing W; Cao Y; Zhou L; Xu M; Sun Z; Li Y; Mai X; Shi L; He C; Zhang F; Duh EJ; Cao Y; Liu X
• Article: NATURE COMMUNICATIONS. 2023;14(1):7610

  Mirabegron displays anticancer effects by globally browning adipose tissues

  Sun X; Sui W; Mu Z; Xie S; Deng J; Li S; Seki T; Wu J; Jing X; He X; Wang Y; Li X; Yang Y; Huang P; Ge M; Cao Y
• Article: ADVANCED SCIENCE. 2023;10(24):e2301505

  Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism

  Wu J; Jing X; Du Q; Sun X; Holgersson K; Gao J; He X; Hosaka K; Zhao C; Tao W; FitzGerald GA; Yang Y; Jensen LD; Cao Y
• Article: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):305

  VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

  Lee C; Chen R; Sun G; Liu X; Lin X; He C; Xing L; Liu L; Jensen LD; Kumar A; Langer HF; Ren X; Zhang J; Huang L; Yin X; Kim J; Zhu J; Huang G; Li J; Lu W; Chen W; Liu J; Hu J; Sun Q; Lu W; Fang L; Wang S; Kuang H; Zhang Y; Tian G; Mi J; Kang B-A; Narazaki M; Prodeus A; Schoonjans L; Ornitz DM; Gariepy J; Eelen G; Dewerchin M; Yang Y; Ou J-S; Mora A; Yao J; Zhao C; Liu Y; Carmeliet P; Cao Y; Li X
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(29):e2303740120

  KRAS mutation-driven angiopoietin 2 bestows anti-VEGF resistance in epithelial carcinomas

  Hosaka K; Andersson P; Wu J; He X; Du Q; Jing X; Seki T; Gao J; Zhang Y; Sun X; Huang P; Yang Y; Ge M; Cao Y
• Review: NATURE REVIEWS DRUG DISCOVERY. 2023;22(6):476-495

  Targeting angiogenesis in oncology, ophthalmology and beyond

  Cao Y; Langer R; Ferrara N
• Article: CANCER COMMUNICATIONS. 2023;43(6):637-660

  Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors

  Hosaka K; Wang C; Zhang S; Lv X; Seki T; Zhang Y; Jing X; Wu J; Du Q; He X; Fan Y; Li X; Kondo M; Yoshihara M; Qian H; Shi L; Zhu P; Xu Y; Yang Y; Cheng T; Cao Y
• Article: NATURE METABOLISM. 2022;4(12):1674-1683

  COVID-19 instigates adipose browning and atrophy through VEGF in small mammals

  Jing X; Wu J; Dong C; Gao J; Seki T; Kim C; Urgard E; Hosaka K; Yang Y; Long S; Huang P; Zheng J; Szekely L; Zhang Y; Tao W; Coquet J; Ge M; Chen Y; Adner M; Cao Y
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(673):eabn9061

  Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia

  Xie S; Jiang C; Wu M; Ye Y; Wu B; Sun X; Lv X; Chen R; Yu W; Sun Q; Wu Y; Que R; Li H; Yang L; Liu W; Zuo J; Jensen LD; Huang G; Cao Y; Yang Y
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(40):e2203307119

  Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo

  Du Q; Wu J; Fischer C; Seki T; Jing X; Gao J; He X; Hosaka K; Tong L; Yasue A; Miyake M; Sobajima M; Oyadomari S; Sun X; Yang Y; Zhou Q; Ge M; Tao W; Yao S; Cao Y
• Corrigendum: NATURE METABOLISM. 2022;4(10):1421

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(10):e005308

  Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells

  Neo SY; Jing X; Tong L; Tong D; Gao J; Chen Z; De Los Santos MC; Burduli N; Ferreira SDS; Wagner AK; Alici E; Rolny C; Cao Y; Lundqvist A
• Article: NATURE. 2022;608(7922):421-428

  Brown-fat-mediated tumour suppression by cold-altered global metabolism

  Seki T; Yang Y; Sun X; Lim S; Xie S; Guo Z; Xiong W; Kuroda M; Sakaue H; Hosaka K; Jing X; Yoshihara M; Qu L; Li X; Chen Y; Cao Y
• Article: NATURE METABOLISM. 2022;4(6):739-758

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2112696119

  Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer

  Kong N; Zhang R; Wu G; Sui X; Wang J; Kim NY; Blake S; De D; Xie T; Cao Y; Tao W
• Article: SCIENCE ADVANCES. 2022;8(2):eabi8683

  Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging

  Xu X; Mu L; Li L; Liang J; Zhang S; Jia L; Yang X; Dai Y; Zhang J; Wang Y; Niu S; Xia G; Yang Y; Zhang Y; Cao Y; Zhang H
• Article: GUT. 2022;71(1):129-147

  Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism

  Sun X; He X; Zhang Y; Hosaka K; Andersson P; Wu J; Wu J; Jing X; Du Q; Hui X; Ding B; Guo Z; Hong A; Liu X; Wang Y; Ji Q; Beyaert R; Yang Y; Li Q; Cao Y
• Journal article: ADVANCED SCIENCE. 2021;8(21)

  Interleukin‐33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage‐Mediated Shedding Mechanism (Adv. Sci. 21/2021)

  Wu J; Chen Z; Wickström SL; Gao J; He X; Jing X; Wu J; Du Q; Yang M; Chen Y; Zhang D; Yin X; Guo Z; Jensen L; Yang Y; Tao W; Lundqvist A; Kiessling R; Cao Y
• Review: JOURNAL OF CLINICAL INVESTIGATION. 2019;129(8):3006-3017

  Adipocyte and lipid metabolism in cancer drug resistance

  Cao Y
• Article: CELL METABOLISM. 2018;28(1):104-117.e5

  Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance

  Iwamoto H; Abe M; Yang Y; Cui D; Seki T; Nakamura M; Hosaka K; Lim S; Wu J; He X; Sun X; Lu Y; Zhou Q; Shi W; Torimura T; Nie G; Li Q; Cao Y
• Editorial comment: CELL METABOLISM. 2018;27(6):1163-1165

  Obesity Protects Cancer from Drugs Targeting Blood Vessels

  Cao Y
• Review: NATURE REVIEWS ENDOCRINOLOGY. 2014;10(9):530-539

  VEGF-targeted cancer therapeutics - paradoxical effects in endocrine organs

  Cao Y
• Review: CELL METABOLISM. 2013;18(4):478-489

  Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity

  Cao Y
• Article: SCIENCE. 2013;341(6141):84-87

  Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

  Molina DM; Jafari R; Ignatushchenko M; Seki T; Larsson EA; Dan C; Sreekumar L; Cao Y; Nordlund P
• Article: CELL METABOLISM. 2013;18(1):118-129

  Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis

  Dong M; Yang X; Lim S; Cao Z; Honek J; Lu H; Zhang C; Seki T; Hosaka K; Wahlberg E; Yang J; Zhang L; Lanne T; Sun B; Li X; Liu Y; Zhang Y; Cao Y
• Review: SCIENCE TRANSLATIONAL MEDICINE. 2011;3(114):114rv3

  Forty-Year Journey of Angiogenesis Translational Research

  Cao Y; Arbiser J; D'Amato RJ; D'Amore PA; Ingber DE; Kerbel R; Klagsbrun M; Lim S; Moses MA; Zetter B; Dvorak H; Langer R
• Article: NATURE MEDICINE. 2011;18(1):100-110

  PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells

  Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E-M; Andersson P; Sasahara M; Larsson O; Galter D; Gao R; Hosaka K; Cao Y
• Article: NATURE REVIEWS CLINICAL ONCOLOGY. 2010;7(10):604-608

  Off-tumor target-beneficial site for antiangiogenic cancer therapy?

  Cao Y
• Article: NATURE REVIEWS DRUG DISCOVERY. 2010;9(2):107-115

  Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

  Cao Y
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2010;2(15):15ps3

  Optimizing the Delivery of Cancer Drugs that Block Angiogenesis

  Cao Y; Langer R
• Review: SCIENCE SIGNALING. 2009;2(59):re1

  Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

  Cao Y
• Article: CELL METABOLISM. 2009;9(1):99-109

  Hypoxia-Independent Angiogenesis in Adipose Tissues during Cold Acclimation

  Xue Y; Petrovic N; Cao R; Larsson O; Lim S; Chen S; Feldmann HM; Liang Z; Zhu Z; Nedergaard J; Cannon B; Cao Y
• Review: NATURE REVIEWS CANCER. 2005;5(9):735-743

  Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis.

  Cao Y
• Article: CANCER CELL. 2004;6(4):333-345

  PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

  Cao RH; Björndahl MA; Religa P; Clasper S; Garvin S; Galter D; Meister B; Ikomi F; Tritsaris K; Dissing S; Ohhashi T; Jackson DG; Cao YH
• Article: NATURE MEDICINE. 2003;9(5):604-613

  Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2

  Cao RH; Bråkenhielm E; Pawliuk R; Wariaro D; Post MJ; Wahlberg E; Leboulch P; Cao YH
• Article: CANCER CELL. 2002;1(1):99-108

  Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers

  Eriksson A; Cao RH; Pawliuk R; Berg SM; Tsang M; Zhou D; Fleet C; Tritsaris K; Dissing S; Leboulch P; Cao YH
• Letter: NATURE. 1999;398(6726):381

  Angiogenesis inhibited by drinking tea.

  Cao Y; Cao R
• Article: SCIENCE. 1996;273(5274):510-513

  Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function

  Cheng H; Cao YH; Olson L
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Medarbetare och kontakt

Gruppledare

• 

  Yihai Cao

  Professor

  Telefon +46852487596

  E-postadress yihai.cao@ki.se

Alla medarbetare i gruppen

• 

  Yihai Cao

  Professor

  Telefon +46852487596

  E-postadress yihai.cao@ki.se
• 

  Renhai Cao

  Forskare

  E-postadress renhai.cao@ki.se
• Li Chen

  Laboratorieassistent

  E-postadress li.chen@ki.se
• Shiji Fang

  Anknuten till Forskning

  E-postadress shiji.fang@ki.se
• Mengqi Guo

  Anknuten till Forskning

  E-postadress mengqi.guo@ki.se
• 

  Kayoko Hosaka

  Forskningsspecialist

  E-postadress kayoko.hosaka@ki.se
• Xu Jing

  Senior Forskningsspecialist

  E-postadress jing.xu.2@ki.se
• Jia Liu

  Anknuten till Forskning

  E-postadress jia.liu@ki.se
• Mingwei Ma

  Anknuten till Forskning

  E-postadress ma.mingwei@ki.se
• 

  Takahiro Seki

  Forskningsspecialist

  E-postadress takahiro.seki@ki.se
• Xiaolu Wang

  Anknuten till Forskning

  E-postadress xiaolu.wang@ki.se