Ryggmärgskretsar för motorisk koordination av hela kroppen – Laurence Pictons grupp

Vår forskning fokuserar på att förstå hur motorisk koordination av hela kroppen uppnås under beteende hos däggdjur. I synnerhet syftar gruppen till att identifiera och karakterisera outforskade sensoriska vägar som ger rörelseåterkoppling baserat på bål- och ryggmärgsrörelser. Vi använder en mängd olika tekniker på möss, inklusive elektrofysiologi med patch-clamp kombinerat med mekanisk manipulation, avbildningstekniker som röntgenanalys och genetisk manipulation kombinerat med beteendeanalys.

Publikationer

Alla gruppmedlemmars publikationer

Journal article: TOXINS. 2025;17(3):140
Botulinum Toxin Type A Exerts Direct Trans-Synaptic Action at Bilateral Spinal Nociceptive Circuits
Nemanic D; Sostaric P; Meglic P; Matak I; Bach-Rojecky L
Review: ANNUAL REVIEW OF NEUROSCIENCE. 2025;:23-41
Circuit Modules for Flexible Locomotion.
Picton L; Pallucchi I; Fontanel P; Bertuzzi M; Song J; El Manira A
Preprint: BIORXIV. 2025
Persistent interferon signaling that causes sensory neuron plasticity and pain in arthritis
Su J; Zhang M-D; Kupari J; Kwak D; Picton L; Xu B; Hu Y; Alvarez AG; Usoskin D; Xu Z; Manira AE; Holmdahl R; Ernfors P
Article: BRAIN. 2024;148(4):1099-1105
ATP1A3 dysfunction causes motor hyperexcitability and afterhyperpolarization loss in a dystonia model
Akkuratov EE; Sorrell F; Picton LD; Sousa VC; Paucar M; Jans D; Svensson L-B; Lindskog M; Fritz N; Liebmann T; Sillar KT; Rosewich H; Svenningsson P; Brismar H; Miles GB; Aperia A
Preprint: BIORXIV. 2024
My friend MIROSLAV: A Hackable Open-Source Hardware and Software Platform for High-Throughput Rodent Activity Monitoring in the Home Cage
Virag D; Homolak J; Kodvanj I; Vargantolić A-M; Perhoč AB; Meglić P; Mužić PŠ; Knezović A; Barilar JO; Cifrek M; Trkulja V; Šalković-Petrišić M
Article: JOURNAL OF NEUROSCIENCE. 2024;44(18):e1607232024
Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice
Bertho M; Caldeira V; Hsu L-J; Loew P; Borgius L; Kiehn O
Doctoral thesis: 2024
Molecular and functional organization of the locomotor networks : from brainstem to spinal cord
Bertho MCV
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2024;962:176242
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Sostaric P; Matic M; Nemanic D; Vasic ZL; Cifrek M; Pirazzini M; Matak I
Journal article: JCI INSIGHT. 2023;8(11):e166978
Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus
Fabris F; Varani S; Tonellato M; Matak I; Sostaric P; Meglic P; Caleo M; Megighian A; Rossetto O; Montecucco C; Pirazzini M
Article: NATURE COMMUNICATIONS. 2023;14(1):873
Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks
Hsu L-J; Bertho M; Kiehn O
Article: NEURON. 2023;111(3):372-386.e4
Brainstem circuits encoding start, speed, and duration of swimming in adult zebrafish
Berg EM; Mrowka L; Bertuzzi M; Madrid D; Picton LD; El Manira A
Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(19):11626
Lasting Peripheral and Central Effects of Botulinum Toxin Type A on Experimental Muscle Hypertonia in Rats
Sostaric P; Vukic B; Tomasic L; Matak I
Article: CURRENT BIOLOGY. 2022;32(16):3515-3528.e4
Developmental switch in the function of inhibitory commissural V0d interneurons in zebrafish
Picton LD; Bjornfors ER; Fontanel P; Pallucchi I; Bertuzzi M; El Manira A
Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(8):4355
Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody
Fabris F; Sostaric P; Matak I; Binz T; Toffan A; Simonato M; Montecucco C; Pirazzini M; Rossetto O
Journal article: CURRENT BIOLOGY. 2022;32(5):1038-1048.e2
Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord
Hachoumi L; Rensner R; Richmond C; Picton L; Zhang H; Sillar KT
Article: BIOMEDICINES. 2021;9(6):598
A Guide to the Generation of a 6-Hydroxydopamine Mouse Model of Parkinson's Disease for the Study of Non-Motor Symptoms
Masini D; Plewnia C; Bertho M; Scalbert N; Caggiano V; Fisone G
Article: NEURON. 2021;109(7):1188-1201.e7
A spinal organ of proprioception for integrated motor action feedback
Picton LD; Bertuzzi M; Pallucchi I; Fontanel P; Dahlberg E; Bjornfors ER; Iacoviello F; Shearing PR; El Manira A
Article: NEURON. 2020;105(6):1048-1061.e4
Multiple Rhythm-Generating Circuits Act in Tandem with Pacemaker Properties to Control the Start and Speed of Locomotion
Song J; Pallucchi I; Ausborn J; Ampatzis K; Bertuzzi M; Fontanel P; Picton LD; El Manira A
Journal article: CURRENT OPINION IN PHYSIOLOGY. 2019;8:170-176
Diversity of neurons and circuits controlling the speed and coordination of locomotion
Bjornfors ER; Picton LD; Song J; El Manira A
Journal article: CURRENT BIOLOGY. 2018;28(24):3911-3923.e2
Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons
Picton LD; Sillar KT; Zhang H-Y
Review: FRONTIERS IN NEURAL CIRCUITS. 2018;12:73
Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish
Berg EM; Bjornfors ER; Pallucchi I; Picton LD; El Manira A
Article: FRONTIERS IN NEUROLOGY. 2018;9:208
Inhibition of mTORC1 Signaling Reverts Cognitive and Affective Deficits in a Mouse Model of Parkinson's Disease
Masini D; Bonito-Oliva A; Bertho M; Fisone G
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Medarbetare och kontakt

Gruppledare

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Besöksadress

Karolinska Institutet, Department of Neuroscience, Biomedicum, B4, Solnavägen 9, Solna, 171 65, Sweden

Postadress

Karolinska Institutet, Department of Neuroscience, Stockholm, 171 77, Sweden