Regulatorisk transkriptomik – Claudia Kutters grupp

Forskningen i vår grupp fokuserar på att identifiera och karakterisera de regulatoriska interaktionerna mellan proteinkodande och icke-kodande RNA (långa icke-kodande, transfer- och små RNA) över hela transkriptom i somatiska däggdjursvävnader och i könsceller. Vårt mål är att få mekanistiska insikter i transkriptionell och post-transkriptionell reglering och processering av RNA under organutveckling, celldifferentiering och sjukdomsprogression.

En del av Institutionen för mikrobiologi, tumör- och cellbiologi

Publikationer
Medarbetare och kontakt

Publikationer

Utvalda publikationer

Article: GENOME RESEARCH. 2022;32(10):1876-1891

Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells.

Geng K; Merino LG; Wedemann L; Martens A; Sobota M; Sanchez YP; Søndergaard JN; White RJ; Kutter C
Article: GUT. 2022;71(10):gutjnl-2021-325109-2092

CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism.

Søndergaard JN; Sommerauer C; Atanasoai I; Hinte LC; Geng K; Guiducci G; Bräutigam L; Aouadi M; Stojic L; Barragan I; Kutter C
Article: GENOME RESEARCH. 2022;32(1):97-110

Cell type-specific analysis by single-cell profiling identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neurons.

Gao W; Gallardo-Dodd CJ; Kutter C
Article: GENOME BIOLOGY AND EVOLUTION. 2021;13(4):evab016

Genome Size Reduction and Transposon Activity Impact tRNA Gene Diversity While Ensuring Translational Stability in Birds.

Ottenburghs J; Geng K; Suh A; Kutter C
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):319

Successful delivery of large-size CRISPR/Cas9 vectors in hard-to-transfect human cells using small plasmids.

Søndergaard JN; Geng K; Sommerauer C; Atanasoai I; Yin X; Kutter C
Article: PLOS GENETICS. 2016;12(5):e1006024

Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States.

Rudolph KLM; Schmitt BM; Villar D; White RJ; Marioni JC; Kutter C; Odom DT
Article: GENOME RESEARCH. 2014;24(11):1797-1807

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface.

Schmitt BM; Rudolph KLM; Karagianni P; Fonseca NA; White RJ; Talianidis I; Odom DT; Marioni JC; Kutter C
Article: SCIENCE. 2012;338(6114):1587-1593

The evolutionary landscape of alternative splicing in vertebrate species.

Barbosa-Morais NL; Irimia M; Pan Q; Xiong HY; Gueroussov S; Lee LJ; Slobodeniuc V; Kutter C; Watt S; Colak R; Kim T; Misquitta-Ali CM; Wilson MD; Kim PM; Odom DT; Frey BJ; Blencowe BJ
Article: PLOS GENETICS. 2012;8(7):e1002841

Rapid turnover of long noncoding RNAs and the evolution of gene expression.

Kutter C; Watt S; Stefflova K; Wilson MD; Goncalves A; Ponting CP; Odom DT; Marques AC
Article: NATURE GENETICS. 2011;43(10):948-955

Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes.

Kutter C; Brown GD; Gonçalves A; Wilson MD; Watt S; Brazma A; White RJ; Odom DT

Medarbetare och kontakt

Gruppledare

Claudia Kutter
Senior Forskare

Telefon +46852482819

E-postadress claudia.kutter@ki.se

Alla medlemmar i gruppen

Carlos Gallardo Dodd
Doktorand

E-postadress carlos.gallardo.dodd@ki.se
Keyi Geng
Postdoktor

E-postadress keyi.geng@ki.se
Claudia Kutter
Senior Forskare

Telefon +46852482819

E-postadress claudia.kutter@ki.se
Qun Li
Postdoktor

E-postadress qun.li@ki.se
Riccardo Mosca
Doktorand

E-postadress riccardo.mosca@ki.se
Christian Sommerauer
Doktorand-L

E-postadress christian.sommerauer@ki.se