Regulatorisk transkriptomik – Claudia Kutters grupp

Forskningen i vår grupp fokuserar på att identifiera och karakterisera de regulatoriska interaktionerna mellan proteinkodande och icke-kodande RNA (långa icke-kodande, transfer- och små RNA) över hela transkriptom i somatiska däggdjursvävnader och i könsceller. Vårt mål är att få mekanistiska insikter i transkriptionell och post-transkriptionell reglering och processering av RNA under organutveckling, celldifferentiering och sjukdomsprogression.

Publikationer

Utvalda publikationer

Article: CANCER LETTERS. 2025;622:217661
Intestinal estrogen receptor beta modulates the murine colon tumor immune microenvironment
Birgersson M; Holm M; Gallardo-Dodd CJ; Chen B; Stepanauskaite L; Hases L; Kutter C; Archer A; Williams C
Article: GENOME RESEARCH. 2022;32(10):1876-1891
Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells
Geng K; Merino LG; Wedemann L; Martens A; Sobota M; Sanchez YP; Sondergaard JN; White RJ; Kutter C
Article: GUT. 2022;71(10):gutjnl-2021-325109-2092
CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism
Sondergaard JN; Sommerauer C; Atanasoai I; Hinte LC; Geng K; Guiducci G; Brautigam L; Aouadi M; Stojic L; Barragan I; Kutter C
Article: GENOME RESEARCH. 2022;32(1):97-110
Cell type-specific analysis by single-cell profiling identifies a stable mammalian tRNA-mRNA interface and increased translation efficiency in neurons
Gao W; Gallardo-Dodd CJ; Kutter C
Article: GENOME BIOLOGY AND EVOLUTION. 2021;13(4):evab016
Genome Size Reduction and Transposon Activity Impact tRNA Gene Diversity While Ensuring Translational Stability in Birds
Ottenburghs J; Geng K; Suh A; Kutter C
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):319
Successful delivery of large-size CRISPR/Cas9 vectors in hard-to-transfect human cells using small plasmids
Sondergaard JN; Geng K; Sommerauer C; Atanasoai I; Yin X; Kutter C
Article: PLOS GENETICS. 2016;12(5):e1006024
Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States
Rudolph KLM; Schmitt BM; Villar D; White RJ; Marioni JC; Kutter C; Odom DT
Article: GENOME RESEARCH. 2014;24(11):1797-1807
High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface
Schmitt BM; Rudolph KLM; Karagianni P; Fonseca NA; White RJ; Talianidis L; Odom DT; Marioni JC; Kutter C
Article: SCIENCE. 2012;338(6114):1587-1593
The Evolutionary Landscape of Alternative Splicing in Vertebrate Species
Barbosa-Morais NL; Irimia M; Pan Q; Xiong HY; Gueroussov S; Lee LJ; Slobodeniuc V; Kutter C; Watt S; Colak R; Kim T; Misquitta-Ali CM; Wilson MD; Kim PM; Odom DT; Frey BJ; Blencowe BJ
Article: PLOS GENETICS. 2012;8(7):e1002841
Rapid Turnover of Long Noncoding RNAs and the Evolution of Gene Expression
Kutter C; Watt S; Stefflova K; Wilson MD; Goncalves A; Ponting CP; Odom DT; Marques AC
Article: NATURE GENETICS. 2011;43(10):948-955
Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes
Kutter C; Brown GD; Goncalves A; Wilson MD; Watt S; Brazma A; White RJ; Odom DT

Regulatorisk transkriptomik – Claudia Kutters grupp

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