Glaukom – Pete Williams forskargrupp

Publikationer

Utvalda publikationer

Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):18

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve.

Tribble JR; Hagström A; Jusseaume K; Lardner E; Wong RC-B; Stålhammar G; Williams PA
Article: JAMA OPHTHALMOLOGY. 2022;140(1):11-18

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.

De Moraes CG; John SWM; Williams PA; Blumberg DM; Cioffi GA; Liebmann JM
Article: REDOX BIOLOGY. 2021;43:101988

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction.

Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Jöe M; Lardner E; Venkataraman AP; Domínguez-Vicent A; Kokkali E; Rho S; Jóhannesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33619-33627

Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin.

Harder JM; Guymer C; Wood JPM; Daskalaki E; Chidlow G; Zhang C; Balasubramanian R; Cardozo BH; Foxworth NE; Deering KE; Ouellette TB; Montgomery C; Wheelock CE; Casson RJ; Williams PA; John SWM
Article: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2020;48(7):903-914

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial.

Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
Article: BRAIN COMMUNICATIONS. 2019;1(1):fcz035

Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma.

Tribble JR; Vasalauskaite A; Redmond T; Young RD; Hassan S; Fautsch MP; Sengpiel F; Williams PA; Morgan JE
Article: SCIENCE. 2017;355(6326):756-760

Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.

Williams PA; Harder JM; Foxworth NE; Cochran KE; Philip VM; Porciatti V; Smithies O; John SWM

Alla gruppmedlemmars publikationer

Review: NEURAL REGENERATION RESEARCH. 2025;20(1):41-53

Pyrroloquinoline quinone: a potential neuroprotective compound for neurodegenerative diseases targeting metabolism.

Canovai A; Williams PA
Editorial comment: NEURAL REGENERATION RESEARCH. 2024;19(8):1637-1638

Glycolysis and glucose metabolism as a target for bioenergetic and neuronal protection in glaucoma.

Williams PA; Casson RJ
Article: NATURE MEDICINE. 2024;:1-9

Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss.

Petriti B; Rabiolo A; Chau K-Y; Williams PA; Montesano G; Lascaratos G; Garway-Heath DF
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):79

Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection.

Rombaut A; Jovancevic D; Wong RC-B; Nicol A; Brautaset R; Finkelstein DI; Nguyen CTO; Tribble JR; Williams PA
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):65

Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection.

Kim M; Kim JY; Rhim W-K; Cimaglia G; Want A; Morgan JE; Williams PA; Park CG; Han DK; Rho S
Article: BMC NEUROLOGY. 2024;24(1):111

Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol.

Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sörensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Morén AF; Kivipelto M; Plavén-Sigray P
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2024;12(1):37

Prophylactic nicotinamide treatment protects from rotenone-induced neurodegeneration by increasing mitochondrial content and volume.

Otmani A; Jóhannesson G; Brautaset R; Tribble JR; Williams PA
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(14):34

Nicotinamide Prevents Retinal Vascular Dropout in a Rat Model of Ocular Hypertension and Supports Ocular Blood Supply in Glaucoma Patients.

Gustavsson ST; Enz TJ; Tribble JR; Nilsson M; Lindqvist A; Lindén C; Hagström A; Rutigliani C; Lardner E; Stålhammar G; Williams PA; Jóhannesson G
Preprint: RESEARCH SQUARE. 2023

Mitochondrial respiratory function is strongly associated with progressive glaucomatous vision loss

Petriti B; Rabiolo A; Chau K-Y; Williams P; Montesano G; Lascaratos G; Garway-Heath D
Review: MOLECULAR NEURODEGENERATION. 2023;18(1):64

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium.

Soucy JR; Aguzzi EA; Cho J; Gilhooley MJ; Keuthan C; Luo Z; Monavarfeshani A; Saleem MA; Wang X-W; Wohlschlegel J; RReSTORe Consortium; Baranov P; Di Polo A; Fortune B; Gokoffski KK; Goldberg JL; Guido W; Kolodkin AL; Mason CA; Ou Y; Reh TA; Ross AG; Samuels BC; Welsbie D; Zack DJ; Johnson TV
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):146

Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection.

Canovai A; Tribble JR; Jöe M; Westerlund DY; Amato R; Trounce IA; Dal Monte M; Williams PA
Review: MOLECULAR ASPECTS OF MEDICINE. 2023;92:101193

Neuroprotection in glaucoma: Mechanisms beyond intraocular pressure lowering.

Tribble JR; Hui F; Quintero H; El Hajji S; Bell K; Di Polo A; Williams PA
Article: GENE THERAPY. 2023;30(6):503-519

Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters.

Nieuwenhuis B; Laperrousaz E; Tribble JR; Verhaagen J; Fawcett JW; Martin KR; Williams PA; Osborne A
Article: BMC CANCER. 2023;23(1):277

A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival.

Herrspiegel C; Plastino F; Lardner E; Seregard S; Williams PA; André H; Stålhammar G
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):18

NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve.

Tribble JR; Hagström A; Jusseaume K; Lardner E; Wong RC-B; Stålhammar G; Williams PA
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)

Glaucoma: Understanding the biological contributions of Aging and Sex

Williams P
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)

Metabolomic profiling of dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

Komaromy A; Harman C; Anderson A; Williams P
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)

Effect of short-term nicotinamide supplementation on inner retinal function in dogs with ADAMTS10-open-angle glaucoma (ADAMTS10-OAG)

Halsmer EL; DeQuattro C; Wang S; Harman C; Anderson A; Williams P; Komaromy AM
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)

Primary open angle glaucoma patients have lower systemic mitochondrial function, associated with lower systemic nicotinamide adenine dinucleotide (NAD) levels, compared to Controls

Petriti B; Rabiolo A; Williams P; Chau K-Y; Lascaratos G; Garway-Heath DF
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)

NMNAT2 is a druggable target for neuroprotection in glaucoma

Williams P; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2023;64(8)

Development of neuroprotective small molecular drugs targeting NMNAT2

Joe M; Tribble JR; Varricchio C; Brancale A; Johannesson G; Wheelock C; Williams P
Article: JOURNAL OF BIOPHOTONICS. 2022;15(12):e202200169

Volume-rendered optical coherence tomography angiography during ocular interventions: Advocating for noninvasive intraoperative retinal perfusion monitoring.

Enz TJ; Maloca PM; Tschopp M; Menke MN; Tribble JR; Williams PA; Inglin N; Steitz U; Scholl HPN; Papazoglou A
Article: DISCOVER ONCOLOGY. 2022;13(1):116

The prognostic implication of latitude in uveal melanoma: a nationwide observational cohort study of all patients born in Sweden between 1947 and 1989.

Stålhammar G; Williams PA; Landelius T
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):118

Widespread retina and optic nerve neuroinflammation in enucleated eyes from glaucoma patients.

Rutigliani C; Tribble JR; Hagström A; Lardner E; Jóhannesson G; Stålhammar G; Williams PA
Review: BMC CANCER. 2022;22(1):398

The rationale for treating uveal melanoma with adjuvant melatonin: a review of the literature.

Hagström A; Kal Omar R; Williams PA; Stålhammar G
Preprint: RESEARCH SQUARE. 2022

The Rationale For Treating Uveal Melanoma With Adjuvant Melatonin: A Review of The Literature

Hagström A; Omar RK; Williams P; Stålhammar G
Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2022;11(2):1-13

Comparative Assessment of Retinal Blood Flow Velocity Changes Following Brimonidine and Brinzolamide Administration Using Retinal Function Imaging.

Enz TJ; Bittner M; Tribble JR; Williams PA; Thiel MA; Schmid MK; Bachmann LM; Bochmann F
Article: JAMA OPHTHALMOLOGY. 2022;140(1):11-18

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.

De Moraes CG; John SWM; Williams PA; Blumberg DM; Cioffi GA; Liebmann JM
Review: FRONTIERS IN NEUROSCIENCE. 2022;16:824054

Glucagon-Like Peptide 1 Receptor Agonists - Potential Game Changers in the Treatment of Glaucoma?

Mouhammad ZA; Vohra R; Horwitz A; Thein A-S; Rovelt J; Cvenkel B; Williams PA; Azuara-Blanco A; Kolko M
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:903436

Valproic Acid Reduces Neuroinflammation to Provide Retinal Ganglion Cell Neuroprotection in the Retina Axotomy Model.

Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022;63(7)

Valproic acid reduces resident neuroinflammation and provides neuroprotection following retinal ganglion cell axotomy

Tribble JR; Kastanaki E; Uslular AB; Rutigliani C; Enz TJ; Williams PA
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022;63(7)

Targeting NMNAT2 for neuroprotection in glaucoma

Williams PA; Tribble JR; Joe M; Brancale A; Varricchio C; Coleman M; Gilley J; Loreto A; Wheelock C; Johannesson G
Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(17):3938

Comparison of Glaucoma-Relevant Transcriptomic Datasets Identifies Novel Drug Targets for Retinal Ganglion Cell Neuroprotection.

Enz TJ; Tribble JR; Williams PA
Article: REDOX BIOLOGY. 2021;43:101988

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction.

Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Jöe M; Lardner E; Venkataraman AP; Domínguez-Vicent A; Kokkali E; Rho S; Jóhannesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
Review: CELLS. 2021;10(6):1402

Neuroprotection in Glaucoma: NAD+/NADH Redox State as a Potential Biomarker and Therapeutic Target.

Petriti B; Williams PA; Lascaratos G; Chau K-Y; Garway-Heath DF
Review: PROGRESS IN RETINAL AND EYE RESEARCH. 2021;81:100881

Retinal energy metabolism in health and glaucoma.

Casson RJ; Chidlow G; Crowston JG; Williams PA; Wood JPM
Review: CELLS. 2021;10(2):295

Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma.

Tribble JR; Hui F; Jöe M; Bell K; Chrysostomou V; Crowston JG; Williams PA
Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):21

Retinal Ganglion Cell Degeneration in a Rat Magnetic Bead Model of Ocular Hypertensive Glaucoma.

Tribble JR; Otmani A; Kokkali E; Lardner E; Morgan JE; Williams PA
Article: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY. 2021;10(1):22

When Is a Control Not a Control? Reactive Microglia Occur Throughout the Control Contralateral Pathway of Retinal Ganglion Cell Projections in Experimental Glaucoma.

Tribble JR; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; André H; Morgan JE; Williams PA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33619-33627

Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin.

Harder JM; Guymer C; Wood JPM; Daskalaki E; Chidlow G; Zhang C; Balasubramanian R; Cardozo BH; Foxworth NE; Deering KE; Ouellette TB; Montgomery C; Wheelock CE; Casson RJ; Williams PA; John SWM
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):216

Retinal ganglion cell degeneration correlates with hippocampal spine loss in experimental Alzheimer's disease.

Bevan RJ; Hughes TR; Williams PA; Good MA; Morgan BP; Morgan JE
Article: JOURNAL OF NEUROINFLAMMATION. 2020;17(1):336

Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice.

Harder JM; Williams PA; Braine CE; Yang HS; Thomas JM; Foxworth NE; John SWM; Howell GR
Article: NATURE COMMUNICATIONS. 2020;11(1):5614

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.

Petrova V; Pearson CS; Ching J; Tribble JR; Solano AG; Yang Y; Love FM; Watt RJ; Osborne A; Reid E; Williams PA; Martin KR; Geller HM; Eva R; Fawcett JW
Preprint: BIORXIV. 2020

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

Tribble JR; Otmani A; Sun S; Ellis SA; Cimaglia G; Vohra R; Jöe M; Lardner E; Venkataraman AP; Domínguez-Vicent A; Kokkali E; Rho S; Jóhannesson G; Burgess RW; Fuerst PG; Brautaset R; Kolko M; Morgan JE; Crowston JG; Votruba M; Williams PA
Review: NUTRIENTS. 2020;12(9):E2871-2871

Potential Therapeutic Benefit of NAD+ Supplementation for Glaucoma and Age-Related Macular Degeneration.

Cimaglia G; Votruba M; Morgan JE; André H; Williams PA
Article: CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY. 2020;48(7):903-914

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial.

Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
Preprint: BIORXIV. 2020

Computational approaches towards reducing contamination in single-cell RNA-seq data

Yousefi S; Chen H; Ingels J; McCarty M; Centeno A; Chintalapudi S; Mulligan M; Williams P; John S; Jones B; Jablonski M; Hollingsworth TJ; Geisert E; Lu L; Williams R
Preprint: RESEARCH SQUARE. 2020

Anaphylatoxin Receptor C3AR1 Promotesoptic Nerve Degeneration in DBA/2J Mice

Harder JM; Williams P; Braine C; Yang H; Thomas J; Foxworth N; John S; Howell G
Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa101

OPA1 deficiency accelerates hippocampal synaptic remodelling and age-related deficits in learning and memory.

Bevan RJ; Williams PA; Waters CT; Thirgood R; Mui A; Seto S; Good M; Morgan JE; Votruba M; Erchova I
Article: MOLECULAR BRAIN. 2020;13(1):81

Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice.

Tribble JR; Harder JM; Williams PA; John SWM
Preprint: BIORXIV. 2020

Oral pyruvate prevents glaucomatous neurodegeneration

Williams P; Harder J; Guymer C; Wood J; Daskalaki E; Chidlow G; Cardozo B; Foxworth N; Cochran K; Ouellette T; Wheelock C; Casson R; John S
Preprint: MEDRXIV. 2020

Improvement in Inner Retinal Function in Glaucoma with Nicotinamide (Vitamin B3) Supplementation: A Crossover Randomised Clinical Trial

Hui F; Tang J; Williams PA; McGuinness MB; Hadoux X; Casson RJ; Coote M; Trounce IA; Martin KR; van Wijngaarden P; Crowston JG
Preprint: BIORXIV. 2020

Protrudin functions as a scaffold in the endoplasmic reticulum to support axon regeneration in the adult central nervous system

Petrova V; Pearson C; Tribble J; Solano A; Reid E; Williams P; Geller H; Eva R; Fawcett J
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2020;61(7)

Improvement in inner retinal function in glaucoma in response to nicotinamide (Vitamin B3) supplementation: a crossover randomized clinical trial

Hui F; Tang J; Williams P; McGuinness M; Hadoux X; Casson RJ; Coote M; Trounce I; Martin KR; van Wijngaarden P; Crowston JG
Preprint: BIORXIV. 2019

Suppression of homeostatic gene expression and increased expression of metabolism-related genes are early features of glaucoma in optic nerve head microglia

Tribble J; Harder J; Williams P; John S
Preprint: BIORXIV. 2019

When is a control not a control? Reactive microglia occur throughout the control contralateral visual pathway in experimental glaucoma

Tribble J; Kokkali E; Otmani A; Plastino F; Lardner E; Vohra R; Kolko M; André H; Morgan J; Williams P
Article: MOLECULAR NEURODEGENERATION. 2019;14(1):6

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.

Williams PA; Braine CE; Kizhatil K; Foxworth NE; Tolman NG; Harder JM; Scott RA; Sousa GL; Panitch A; Howell GR; John SWM
Article: BRAIN COMMUNICATIONS. 2019;1(1):fcz035

Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma.

Tribble JR; Vasalauskaite A; Redmond T; Young RD; Hassan S; Fautsch MP; Sengpiel F; Williams PA; Morgan JE
Article: MOLECULAR BRAIN. 2018;11(1):69

Digestion of the glycosaminoglycan extracellular matrix by chondroitinase ABC supports retinal ganglion cell dendritic preservation in a rodent model of experimental glaucoma.

Tribble JR; Williams PA; Caterson B; Sengpiel F; Morgan JE
Article: CELL DEATH & DISEASE. 2018;9(6):705

Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice.

Harder JM; Williams PA; Soto I; Foxworth NE; Fernandes KA; Freeburg NF; Libby RT; John SWM
Article: NATURE COMMUNICATIONS. 2018;9(1):2278

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.

Choquet H; Paylakhi S; Kneeland SC; Thai KK; Hoffmann TJ; Yin J; Kvale MN; Banda Y; Tolman NG; Williams PA; Schaefer C; Melles RB; Risch N; John SWM; Nair KS; Jorgenson E
Article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2018;11(1):e1356956

Nicotinamide treatment robustly protects from inherited mouse glaucoma.

Williams PA; Harder JM; Cardozo BH; Foxworth NE; John SWM
Review: JOURNAL OF GLAUCOMA. 2017;26(12):1161-1168

Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma.

Williams PA; Harder JM; John SWM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(19):E3839-E3848

Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.

Harder JM; Braine CE; Williams PA; Zhu X; MacNicoll KH; Sousa GL; Buchanan RA; Smith RS; Libby RT; Howell GR; John SWM
Article: JOURNAL OF NEUROINFLAMMATION. 2017;14(1):93

GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma.

Williams PA; Braine CE; Foxworth NE; Cochran KE; John SWM
Article: EXPERIMENTAL EYE RESEARCH. 2017;157:20-27

Neuroinflammation in glaucoma: A new opportunity.

Williams PA; Marsh-Armstrong N; Howell GR; Lasker/IRRF Initiative on Astrocytes and Glaucomat
Article: SCIENCE. 2017;355(6326):756-760

Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.

Williams PA; Harder JM; Foxworth NE; Cochran KE; Philip VM; Porciatti V; Smithies O; John SWM
Article: FRONTIERS IN NEUROSCIENCE. 2017;11:232

Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma.

Williams PA; Harder JM; Foxworth NE; Cardozo BH; Cochran KE; John SWM
Article: MOLECULAR NEURODEGENERATION. 2016;11:26

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.

Williams PA; Tribble JR; Pepper KW; Cross SD; Morgan BP; Morgan JE; John SWM; Howell GR
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016;57(12)

The yin and yang of the complement cascade in glaucoma - the importance of timing and location

Howell GR; Williams P; Harder J; Tribble J; Pepper K; Cross S; Morgan P; Morgan JE; John SW
Article: EXPERIMENTAL EYE RESEARCH. 2015;141:42-56

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.

Fernandes KA; Harder JM; Williams PA; Rausch RL; Kiernan AE; Nair KS; Anderson MG; John SWM; Howell GR; Libby RT
Article: IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING. 2015;23(4):655-664

A Miniature, Fiber-Coupled, Wireless, Deep-Brain Optogenetic Stimulator.

Lee ST; Williams PA; Braine CE; Lin D-T; John SWM; Irazoqui PP
Article: NEUROBIOLOGY OF AGING. 2013;34(7):1799-1806

Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease.

Williams PA; Thirgood RA; Oliphant H; Frizzati A; Littlewood E; Votruba M; Good MA; Williams J; Morgan JE
Article: PLOS ONE. 2013;8(8):e72282

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.

Williams PA; Howell GR; Barbay JM; Braine CE; Sousa GL; John SWM; Morgan JE
Article: BRAIN. 2012;135(Pt 2):493-505

Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity.

Williams PA; Piechota M; von Ruhland C; Taylor E; Morgan JE; Votruba M
Article: EXPERIMENTAL EYE RESEARCH. 2011;93(5):771-777

Specific deficits in visual electrophysiology in a mouse model of dominant optic atrophy.

Barnard AR; Charbel Issa P; Perganta G; Williams PA; Davies VJ; Sekaran S; Votruba M; MacLaren RE
Published conference paper: VISION RESEARCH. 2011;51(2):229-234

Mouse models of dominant optic atrophy: what do they tell us about the pathophysiology of visual loss?

Williams PA; Morgan JE; Votruba M
Article: BRAIN. 2010;133(10):2942-2951

Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy.

Williams PA; Morgan JE; Votruba M
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Glaukom – Pete Williams forskargrupp

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Glaukom – Pete Williams forskargrupp

600 000 kronor i anslag från stiftelsen Promobilia till forskning om glaukom

Publikationer

Utvalda publikationer

Alla gruppmedlemmars publikationer

Medarbetare och kontakt

Gruppledare

Alla medlemmar i gruppen

Forskningsprojekt

Mer information

Mer information