Psykofarmakologi, schizofreni och drogmissbruk – Jari Tiihonens forskargrupp

Publikationer

Utvalda publikationer

• Journal article: WORLD PSYCHIATRY. 2026;25(1):117-124

  Representation and outcomes of individuals with major depression in routine care who are ineligible for randomized controlled trials: a nationwide register-based study

  Hamina A; Pinzon-espinosa J; Taipale H; Schneider-thoma J; Radua J; Efthimiou O; Cardoner N; Correll CU; Fusar-poli P; Mittendorfer-rutz E; Penninx BWJH; Ruhe HG; Tanskanen A; Vinkers CH; Leucht S; Vieta E; Cipriani A; Tiihonen J; Luykx JJ
• Journal article: NATURE COMMUNICATIONS. 2025;16(1):10612

  Human oligodendrocyte progenitor cells mediate synapse elimination through TAM receptor activation

  Gkogka A; Malwade S; Koskuvi M; Ohtonen S; Molnar E; Bose R; Ceccatelli S; Koistinaho J; Tiihonen J; Schalling M; Samudyata S; Sellgren CM
• Journal article: LANCET PSYCHIATRY. 2025;12(12):921-931

  Transdiagnostic effectiveness and safety of clozapine in individuals with psychotic, affective, and personality disorders: nationwide and meta-analytic comparisons with other antipsychotics

  Luykx JJ; Colgan M; Vieta E; Hamina A; Schulte PFJ; Correll CU; Mittendorfer-Rutz E; Siskind D; Lieslehto J; Tanskanen A; Tiihonen J; Taipale H
• Journal article: LANCET PSYCHIATRY. 2025;12(8):568-578

  Real-world effectiveness of clozapine augmentation with antidepressants: within-subject data evidence from two European nationwide cohorts

  Taipale H; Siskind D; Tanskanen A; Mittendorfer-Rutz E; Correll CU; Tiihonen J
• Article: WORLD PSYCHIATRY. 2025;24(2):250-259

  Effectiveness of clozapine augmentation with specific doses of other antipsychotics in schizophrenia: a meta-analysis from two nationwide cohorts

  Tiihonen J; Tanskanen A; Mittendorfer-Rutz E; Howes OD; Correll CU; Siskind D; Taipale H
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2025;182(4):389-400

  Kynurenic Acid and Promotion of Activity-Dependent Synapse Elimination in Schizophrenia

  Orhan F; Malwade S; Khanlarkhani N; Gkogka A; Langeder A; Jungholm O; Koskuvi M; Lehtonen S; Schwieler L; Jardemark K; Tiihonen J; Koistinaho J; Erhardt S; Engberg G; Samudyata S; Sellgren CM
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2025;182(4):341-348

  Continuous Dopamine D2 Receptor Blockade and Long-Term Outcome in First-Episode Schizophrenia

  Tiihonen J; Tanskanen A; Solmi M; Rubio JM; Correll CU; Kane JM; Taipale H
• Article: LANCET PSYCHIATRY. 2025;12(3):198-207

  Real-world effectiveness of pharmacological maintenance treatment of bipolar depression: a within-subject analysis in a Swedish nationwide cohort

  Ermis C; Taipale H; Tanskanen A; Vieta E; Correll CU; Mittendorfer-Rutz E; Tiihonen J
• Article: LANCET PSYCHIATRY. 2025;12(2):122-130

  Comparative effectiveness of antipsychotic treatment strategies for relapse prevention in first-episode schizophrenia in Finland: a population-based cohort study.

  Taipale H; Tanskanen A; Howes O; Correll CU; Kane JM; Tiihonen J
• Article: JAMA PSYCHIATRY. 2025;82(1):94-98

  Repurposing Semaglutide and Liraglutide for Alcohol Use Disorder

  Lahteenvuo M; Tiihonen J; Solismaa A; Tanskanen A; Mittendorfer-Rutz E; Taipale H
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2024;181(10):879-892

  High Burden of Ileus and Pneumonia in Clozapine-Treated Individuals With Schizophrenia: A Finnish 25-Year Follow-Up Register Study

  Partanen JJ; Happola P; Kampe A; Ahola-Olli A; Hellsten A; Rask SM; Haaki W; Hietala J; Kampman O; Tiihonen J; Tanskanen AJ; Daly MJ; Ripatti S; Palotie A; Taipale H; Lahteenvuo M; Koskela JT
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2024;181(10):893-900

  Real-World Effectiveness of Menopausal Hormone Therapy in Preventing Relapse in Women With Schizophrenia or Schizoaffective Disorder

  Brand BA; Sommer IE; Gangadin SS; Tanskanen A; Tiihonen J; Taipale H
• Article: JAMA PSYCHIATRY. 2024;81(10):967-975

  Pneumonia Risk, Antipsychotic Dosing, and Anticholinergic Burden in Schizophrenia

  Luykx JJ; Correll CU; Manu P; Tanskanen A; Hasan A; Tiihonen J; Taipale H
• Article: WORLD PSYCHIATRY. 2024;23(2):276-284

  Real-world effectiveness of antidepressants, antipsychotics and their combinations in the maintenance treatment of psychotic depression. Evidence from within-subject analyses of two nationwide cohorts

  Taipale H; Lieslehto J; Laehteenvuo M; Hamina A; Tanskanen A; Mittendorfer-Rutz E; Paljaervi T; Solmi M; Cipriani A; Correll CU; Tiihonen J
• Article: LANCET PSYCHIATRY. 2024;11(6):443-450

  Long-term persistence of the risk of agranulocytosis with clozapine compared with other antipsychotics: a nationwide cohort and case-control study in Finland

  Rubio JM; Kane JM; Tanskanen A; Tiihonen J; Taipale H
• Article: LANCET PSYCHIATRY. 2024;11(2):102-111

  Efficacy and effectiveness of antipsychotics in schizophrenia: network meta-analyses combining evidence from randomised controlled trials and real-world data

  Efthimiou O; Taipale H; Radua J; Schneider-Thoma J; Pinzon-Espinosa J; Ortuno M; Vinkers CH; Mittendorfer-Rutz E; Cardoner N; Tanskanen A; Fusar-Poli P; Cipriani A; Vieta E; Leucht S; Tiihonen J; Luykx JJ
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2023;180(5):377-385

  Safety of Antipsychotic Polypharmacy Versus Monotherapy in a Nationwide Cohort of 61,889 Patients With Schizophrenia

  Taipale H; Tanskanen A; Tiihonen J
• Article: JAMA PSYCHIATRY. 2023;80(2):167-175

  Association of Treatment-Resistant Depression With Patient Outcomes and Health Care Resource Utilization in a Population-Wide Study

  Lundberg J; Cars T; Loeoev S-A; Soederling J; Sundstroem J; Tiihonen J; Leval A; Gannedahl A; Bjoerkholm C; Sjaelin M; Hellner C
• Article: JAMA PSYCHIATRY. 2023;80(1):31-39

  Association of Pharmacological Treatments and Hospitalization and Death in Individuals With Amphetamine Use Disorders in a Swedish Nationwide Cohort of 13 965 Patients

  Heikkinen M; Taipale H; Tanskanen A; Mittendorfer-Rutz E; Lahteenvuo M; Tiihonen J
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2022;179(12):938-946

  Effectiveness of Antipsychotic Use for Reducing Risk of Work Disability: Results From a Within-Subject Analysis of a Swedish National Cohort of 21,551 Patients With First-Episode Nonaffective Psychosis

  Solmi M; Taipale H; Holm M; Tanskanen A; Mittendorfer-Rutz E; Correll CU; Tiihonen J
• Review: WORLD PSYCHIATRY. 2022;21(2):248-271

  Mortality in people with schizophrenia: a systematic review and meta-analysis of relative risk and aggravating or attenuating factors

  Correll CU; Solmi M; Croatto G; Schneider LK; Rohani-Montez SC; Fairley L; Smith N; Bitter I; Gorwood P; Taipale H; Tiihonen J
• Article: LANCET PSYCHIATRY. 2022;9(5):353-362

  Long-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland

  Tiihonen J; Tanskanen A; Bell JS; Dawson JL; Kataja V; Taipale H
• Article: LANCET PSYCHIATRY. 2022;9(4):271-279

  Real-world effectiveness of antipsychotic doses for relapse prevention in patients with first-episode schizophrenia in Finland: a nationwide, register-based cohort study

  Taipale H; Tanskanen A; Correll CU; Tiihonen J
• Article: JAMA PSYCHIATRY. 2022;79(3):210-218

  Representation and Outcomes of Individuals With Schizophrenia Seen in Everyday Practice Who Are Ineligible for Randomized Clinical Trials

  Taipale H; Schneider-Thoma J; Pinzon-Espinosa J; Radua J; Efthimiou O; Vinkers CH; Mittendorfer-Rutz E; Cardoner N; Pintor L; Tanskanen A; Tomlinson A; Fusar-Poli P; Cipriani A; Vieta E; Leucht S; Tiihonen J; Luykx JJ
• Review: TRENDS IN NEUROSCIENCES. 2022;45(1):8-26

  The iPSC perspective on schizophrenia

  Rasanen N; Tiihonen J; Koskuvi M; Lehtonen S; Koistinaho J
• Article: LANCET PSYCHIATRY. 2021;8(10):883-891

  Antipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in Finland

  Taipale H; Solmi M; Lahteenvuo M; Tanskanen A; Correll CU; Tiihonen J
• Article: LANCET PSYCHIATRY. 2020;7(9):749-761

  Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis

  Rubio JM; Schoretsanitis G; John M; Tiihonen J; Taipale H; Guinart D; Malhotra AK; Correll CU; Kane JM
• Article: WORLD PSYCHIATRY. 2020;19(1):61-68

  20-year follow-up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)

  Taipale H; Tanskanen A; Mehtala J; Vattulainen P; Correll CU; Tiihonen J
• Article: NATURE COMMUNICATIONS. 2019;10(1):3933

  Sex-specific transcriptional and proteomic signatures in schizophrenia

  Tiihonen J; Koskuvi M; Storvik M; Hyotylainen I; Gao Y; Puttonen KA; Giniatullina R; Poguzhelskaya E; Ojansuu I; Vaurio O; Cannon TD; Lonnqvist J; Therman S; Suvisaari J; Kaprio J; Cheng L; Hill AF; Lahteenvuo M; Tohka J; Giniatullin R; Lehtonen S; Koistinaho J
• Article: JAMA PSYCHIATRY. 2019;76(5):499-507

  Association of Antipsychotic Polypharmacy vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia

  Tiihonen J; Taipale H; Mehtala J; Vattulainen P; Correll CU; Tanskanen A
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2018;175(8):765-773

  20-Year Nationwide Follow-Up Study on Discontinuation of Antipsychotic Treatment in First-Episode Schizophrenia

  Tiihonen J; Tanskanen A; Taipale H
• Article: JAMA PSYCHIATRY. 2018;75(4):347-355

  Real-world Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder

  Lahteenvuo M; Tanskanen A; Taipale H; Hoti F; Vattulainen P; Vieta E; Tiihonen J
• Article: JAMA PSYCHIATRY. 2017;74(12):1242-1250

  Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior

  Tielbeek JJ; Johansson A; Polderman TJC; Rautiainen M-R; Jansen P; Taylor M; Tong X; Lu Q; Burt AS; Tiemeier H; Viding E; Plomin R; Martin NG; Heath AC; Madden PAF; Montgomery G; Beaver KM; Waldman I; Gelernter J; Kranzler HR; Farrer LA; Perry JRB; Munafo M; LoParo D; Paunio T; Tiihonen J; Mous SE; Pappa I; de Leeuw C; Watanabe K; Hammerschlag AR; Salvatore JE; Aliev F; Bigdeli TB; Dick D; Faraone SV; Popma A; Medland SE; Posthuma D
• Article: LANCET PSYCHIATRY. 2017;4(7):547-553

  Pharmacological treatments and risk of readmission to hospital for unipolar depression in Finland: a nationwide cohort study

  Tiihonen J; Tanskanen A; Hoti F; Vattulainen P; Taipale H; Mehtala J; Lahteenvuo M
• Article: JAMA PSYCHIATRY. 2017;74(7):686-693

  Real-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With Schizophrenia

  Tiihonen J; Mittendorfer-Rutz E; Majak M; Mehtala J; Hoti F; Jedenius E; Enkusson D; Leval A; Sermon J; Tanskanen A; Taipale H
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2016;173(6):600-606

  Mortality and Cumulative Exposure to Antipsychotics, Antidepressants, and Benzodiazepines in Patients With Schizophrenia: An Observational Follow-Up Study

  Tiihonen J; Mittendorfer-Rutz E; Torniainen M; Alexanderson K; Tanskanen A
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2012;169(5):531-536

  Naltrexone Implant for the Treatment of Polyd rug Dependence: A Randomized Controlled Trial

  Tiihonen J; Krupitsky E; Verbitskaya E; Blokhina E; Mamontova O; Fohr J; Tuomola P; Kuoppasalmi K; Kiviniemi V; Zwartau E
• Article: ARCHIVES OF GENERAL PSYCHIATRY. 2012;69(5):476-483

  Polypharmacy With Antipsychotics, Antidepressants, or Benzodiazepines and Mortality in Schizophrenia

  Tiihonen J; Suokas JT; Suvisaari JM; Haukka J; Korhonen P
• Article: AMERICAN JOURNAL OF PSYCHIATRY. 2011;168(6):603-609

  A Nationwide Cohort Study of Oral and Depot Antipsychotics After First Hospitalization for Schizophrenia

  Tiihonen J; Haukka J; Taylor M; Haddad PM; Patel MX; Korhonen P
• Visa fler

Medarbetare och kontakt

Gruppledare

• 

  Jari Tiihonen

  Professor/Specialistläkare

  Telefon +46852485283

  E-postadress jari.tiihonen@ki.se

Alla medarbetare i gruppen

• 

  Jonas Forsman

  Anknuten till Forskning

  E-postadress jonas.forsman@ki.se
• 

  Johanna Simin

  Anknuten till Forskning

  E-postadress johanna.simin@ki.se
• Lenka Sivak

  Doktorand

  E-postadress lenka.sivak@ki.se
• 

  Antti Tanskanen

  Forskningsspecialist

  Telefon +46852482792

  E-postadress antti.tanskanen@ki.se