Lars Jakobssons grupp

We are studying how blood and lymphatic vessels acquire and maintain their architecture and function in development and disease, aiming to improve therapies of vascular-connected pathologies. The research is directly related to vascular anomalies, cancer, heart disease, stroke, bleeding disorders, diabetic complications, eye disease, and oedema.

Publikationer

Utvalda publikationer

Article: ANGIOGENESIS. 2025;28(1):6
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT
Queiro-Palou A; Jin Y; Jakobsson L
Article: FLUIDS AND BARRIERS OF THE CNS. 2024;21(1):35
Analysis of ischemic stroke-mediated effects on blood-brain barrier properties along the arteriovenous axis assessed by intravital two-photon imaging
Protzmann J; Jung F; Jakobsson L; Fredriksson L
Article: SCIENCE. 2024;383(6683):eade8064
Corpora cavernosa fibroblasts mediate penile erection
Guimaraes EL; Dias DO; Hau WF; Julien A; Holl D; Garcia-Collado M; Savant S; Vagesjo E; Phillipson M; Jakobsson L; Goritz C
Article: EXPERIMENTAL EYE RESEARCH. 2023;237:109674
Anatomy of the complete mouse eye vasculature explored by light-sheet fluorescence microscopy exposes subvascular-specific remodeling in development and pathology
Krimpenfort LT; Garcia-Collado M; van Leeuwen T; Locri F; Luik A-L; Queiro-Palou A; Kanatani S; Andre H; Uhlen P; Jakobsson L
Article: MATRIX BIOLOGY. 2023;121:56-73
Endothelial basement membrane laminins- new players in mouse and human myoendothelial junctions and shear stress communication
Luik A-L; Hannocks M-J; Loismann S; Kapupara K; Cerina M; Stoel MVD; Tsytsyura Y; Glyvuk N; Nordenvall C; Klingauf J; Huveneers S; Meuth S; Jakobsson L; Sorokin L
Article: CIRCULATION RESEARCH. 2020;126(2):243-257
Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling
Tual-Chalot S; Garcia-Collado M; Redgrave RE; Singh E; Davison B; Park C; Lin H; Luli S; Jin Y; Wang Y; Lawrie A; Jakobsson L; Arthur HM
Article: SCIENTIFIC REPORTS. 2018;8(1):10672
Characterization of multi-cellular dynamics of angiogenesis and vascular remodelling by intravital imaging of the wounded mouse cornea
Wang Y; Jin Y; Lavina B; Jakobsson L
Article: DEVELOPMENT. 2017;144(19):3590-3601
Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity
Wang Y; Jin Y; Mae MA; Zhang Y; Ortsater H; Betsholtz C; Makinen T; Jakobsson L
Article: NATURE CELL BIOLOGY. 2017;19(6):639-652
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
Jin Y; Muhl L; Burmakin M; Wang Y; Duchez A-C; Betsholtz C; Arthur HM; Jakobsson L
Article: NATURE CELL BIOLOGY. 2017;19(6):653-665
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues
Sugden WW; Meissner R; Aegerter-Wilmsen T; Tsaryk R; Leonard EV; Bussmann J; Hamm MJ; Herzog W; Jin Y; Jakobsson L; Denz C; Siekmann AF
Article: JOURNAL OF CELL SCIENCE. 2017;130(8):1365-1378
Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling
Muhl L; Folestad EB; Gladh H; Wang Y; Moessinger C; Jakobsson L; Eriksson U
Article: SCIENCE SIGNALING. 2016;9(438):ra76
RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms
Yang J; Wu C; Stefanescu I; Jakobsson L; Chervoneva I; Horowitz A
Article: ONCOGENE. 2016;35(6):748-760
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sunds M; Karlsson MCI; Fuxe J
Review: EXPERIMENTAL CELL RESEARCH. 2013;319(9):1264-1270
Transforming growth factor β family members in regulation of vascular function: In the light of vascular conditional knockouts
Jakobsson L; van Meeteren LA
Article: DEVELOPMENTAL CELL. 2012;23(3):587-599
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen BL; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Article: CANCERS. 2012;4(2):400-419
The dynamics of developmental and tumor angiogenesis-a comparison.
Jin Y; Jakobsson L
Article: NATURE CELL BIOLOGY. 2011;13(10):1202-1213
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
Tammela T; Zarkada G; Nurmi H; Jakobsson L; Heinolainen K; Tvorogov D; Zheng W; Franco CA; Murtomaki A; Aranda E; Miura N; Yla-Herttuala S; Fruttiger M; Makinen T; Eichmann A; Pollard JW; Gerhardt H; Alitalo K
Article: NATURE CELL BIOLOGY. 2010;12(10):943-953
Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Jakobsson L; Franco CA; Bentley K; Collins RT; Ponsioen B; Aspalter IM; Rosewell I; Busse M; Thurston G; Medvinsky A; Schulte-Merker S; Gerhardt H
Article: BLOOD. 2008;112(9):3638-3649
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization
Kawamura H; Li X; Goishi K; van Meeteren LA; Jakobsson L; Cebe-Suarez S; Shimizu A; Edholm D; Ballmer-Hofer K; Kjellen L; Klagsbrun M; Claesson-Welsh L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(20):13905-13912
Endothelial cell migration in stable gradients of vascular endothelial growth factor a and fibroblast growth factor 2 - Effects on chemotaxis and chemokinesis
Barkefors I; Le Jan S; Jakobsson L; Hejll E; Carlson G; Johansson H; Jarvius J; Park JW; Jeon NL; Kreuger J
Article: FASEB JOURNAL. 2008;22(5):1530-1539
Laminin deposition is dispensable for vasculogenesis but regulates blood vessel diameter independent of flow
Jakobsson L; Domogatskaya A; Tryggvason K; Edgar D; Claesson-Welsh L
Article: GENES & DEVELOPMENT. 2007;21(16):2055-2068
Angiomotin regulates endothelial cell migration during embryonic angiogenesis
Aase K; Ernkvist M; Ebarasi L; Jakobsson L; Majumdar A; Yi C; Birot O; Ming Y; Kvanta A; Edholm D; Aspenstrom P; Kissil J; Claesson-Welsh L; Shimono A; Holmgren L
Review: JOURNAL OF CELL BIOLOGY. 2007;177(5):751-755
Building blood vessels - stem cell models in vascular biology
Jakobsson L; Kreuger J; Claesson-Welsh L
Article: DEVELOPMENTAL CELL. 2006;10(5):625-634
Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis
Jakobsson L; Kreuger J; Holmborn K; Lundin L; Eriksson I; Kjellén L; Claesson-Welsh L
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