Felveckning av protein och förebyggande av molekylära chaperoner i cancer och neurodegenerativa sjukdomar – Gefei Chens forskargrupp

Publikationer

Utvalda publikationer

• Article: THE FEBS JOURNAL. 2020;287(13):2823-2833

  High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry

  Kaldmae M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Lain S; Biverstal H; Jornvall H; Lane DP; Rising A; Johansson J; Landreh M
• Article: SCIENTIFIC REPORTS. 2020;10(1):235

  High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain

  Abelein A; Chen G; Kitoka K; Aleksis R; Oleskovs F; Sarr M; Landreh M; Pahnke J; Nordling K; Kronqvist N; Jaudzems K; Rising A; Johansson J; Biverstal H
• Article: THE FEBS JOURNAL. 2018;285(10):1873-1885

  A spidroin-derived solubility tag enables controlled aggregation of a designed amyloid protein

  Sarr M; Kronqvist N; Chen G; Aleksis R; Purhonen P; Hebert H; Jaudzems K; Rising A; Johansson J
• Article: CHEMBIOCHEM. 2015;16(12):1720-1724

  Diversified Structural Basis of a Conserved Molecular Mechanism for pH-Dependent Dimerization in Spider Silk N-Terminal Domains

  Otikovs M; Chen G; Nordling K; Landreh M; Meng Q; Joernvall H; Kronqvist N; Rising A; Johansson J; Jaudzems K
• Article: PLOS BIOLOGY. 2014;12(8):e1001921

  Carbonic Anhydrase Generates CO₂ and H⁺ That Drive Spider Silk Formation Via Opposite Effects on the Terminal Domains

  Andersson M; Chen G; Otikovs M; Landreh M; Nordling K; Kronqvist N; Westermark P; Jornvall H; Knight S; Ridderstrale Y; Holm L; Meng Q; Jaudzems K; Chesler M; Johansson J; Rising A
• Article: NATURE COMMUNICATIONS. 2014;5:3254

  Sequential pH-driven dimerization and stabilization of the N-terminal domain enables rapid spider silk formation

  Kronqvist N; Otikovs M; Chmyrov V; Chen G; Andersson M; Nordling K; Landreh M; Sarr M; Jornvall H; Wennmalm S; Widengren J; Meng Q; Rising A; Otzen D; Knight SD; Jaudzems K; Johansson J
• Article: PLOS ONE. 2012;7(12):e52293

  Full-Length Minor Ampullate Spidroin Gene Sequence

  Chen G; Liu X; Zhang Y; Lin S; Yang Z; Johansson J; Rising A; Meng Q

Medarbetare och kontakt

Gruppledare

• 

  Gefei Chen

  Senior Forskare

  E-postadress gefei.chen@ki.se

Alla medarbetare i gruppen

• 

  Gefei Chen

  Senior Forskare

  E-postadress gefei.chen@ki.se
• Cloé Moëlo

  Postdoktor

  E-postadress cloe.moelo@ki.se