Immunbristsjukdomar – Lisa Westerbergs grupp

Det övergripande målet med vår forskning är att förstå hur ett nedsatt immunförsvar leder till immunbristsjukdom med hög förekomst av autoimmunitet och hematologisk cancer. Vi har särskilt fokus på hur medfödda mutationer i proteiner som reglerar immuncellers cytoskelett leder till förändrad cellrörelse, kommunikation mellan celler och påverkan i kärnan för uttryck av gener och stabilitet av genomet.

Publikationer

Utvalda publikationer

Preprint: BIORXIV. 2025
AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cells
He M; D’Aulerio R; Pinho LG; Doukoumopoulos E; Yong T; Vieira RC; Oliveira MMS; Galvani RG; Sedimbi S; Seitz C; Kuznetsov NV; Zuriaga MA; Kitamura D; Fuster JJ; Cotta-de-Almeida V; Ström L; Degn SE; Westerberg LS
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(5):e2350450
Controlled WASp activity regulates the proliferative response for Treg cell differentiation in the thymus
Vasconcelos-Fontes L; Vieira RC; He M; Ferreira-Reis R; Jurberg AD; Mendes-da-Cruz DA; Andersson J; Cotta-de-Almeida V; Westerberg LS
Article: SCIENCE ADVANCES. 2023;9(34):eadg1610
Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells
Gallardo-Dodd CJ; Oertlin C; Record J; Galvani RG; Sommerauer C; Kuznetsov NV; Doukoumopoulos E; Ali L; Oliveira MMS; Seitz C; Percipalle M; Nikic T; Sadova AA; Shulgina SM; Shmarov VA; Kutko OV; Vlasova DD; Orlova KD; Rykova MP; Andersson J; Percipalle P; Kutter C; Ponomarev SA; Westerberg LS
Article: BRITISH JOURNAL OF CANCER. 2023;128(6):982-991
Increased cross-presentation by dendritic cells and enhanced anti-tumour therapy using the Arp2/3 inhibitor CK666
Oliveira MMS; D'Aulerio R; Yong T; He M; Baptista MAP; Nylen S; Westerberg LS
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2022;111(4):793-803
The WASp L272P gain-of-function mutation alters dendritic cell coordination of actin dynamics for migration and adhesion
Oliveira MMS; Kung S-Y; Moreau HD; Maurin M; Record J; Sanseau D; Nylen S; Lennon-Dumenil A-M; Westerberg LS
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(3):1069-1084
Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation
He M; Saeed MB; Record J; Keszei M; Pinho LG; Vasconcelos-Fontes L; D'Aulerio R; Vieira R; Oliveira MMS; Geyer C; Bohaumilitzky L; Thiemann M; Deordieva E; Buedts L; Lopes JPM; Pershin D; Hammarstrom L; Xia Y; Zhao X; Cunningham-Rundles C; Thrasher AJ; Burns SO; Cotta-de-Almeida V; Liu C; Shcherbina A; Vandenberghe P; Westerberg LS
Article: JCI INSIGHT. 2021;6(6):140273
Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells
Kritikou JS; Oliveira MMS; Record J; Saeed MB; Nigam SM; He M; Keszei M; Wagner AK; Brauner H; Sendel A; Sedimbi SK; Rentouli S; Lane DP; Snapper SB; Karre K; Vandenberghe P; Orange JS; Westerberg LS
Article: HAEMATOLOGICA. 2020;105(5):1339-1350
An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma
Record J; Sendel A; Kritikou JS; Kuznetsov NV; Brauner H; He M; Nagy N; Oliveira MMS; Griseti E; Haase CB; Dahlstrom J; Boddul S; Wermeling F; Thrasher AJ; Liu C; Andersson J; Claesson H-E; Winqvist O; Burns SO; Bjorkholm M; Westerberg LS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(9):4115-4131
Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive
Keszei M; Record J; Kritikou JS; Wurzer H; Geyer C; Thiemann M; Drescher P; Brauner H; Kocher L; James J; He M; Baptista MAP; Dahlberg CIM; Biswas A; Lain S; Lane DP; Song W; Putsep K; Vandenberghe P; Snapper SB; Westerberg LS
Article: GENOME MEDICINE. 2017;9(1):91
Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells
Kuznetsov NV; Almuzzaini B; Kritikou JS; Baptista MAP; Oliveira MMS; Keszei M; Snapper SB; Percipalle P; Westerberg LS
Article: NATURE COMMUNICATIONS. 2016;7:12175
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells
Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Lieden A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylen S; Westerberg LS

Immunbristsjukdomar – Lisa Westerbergs grupp

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