Immunbristsjukdomar – Lisa Westerbergs grupp

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Article: SCIENCE ADVANCES. 2023;9(34):eadg1610

Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells.

Gallardo-Dodd CJ; Oertlin C; Record J; Galvani RG; Sommerauer C; Kuznetsov NV; Doukoumopoulos E; Ali L; Oliveira MMS; Seitz C; Percipalle M; Nikić T; Sadova AA; Shulgina SM; Shmarov VA; Kutko OV; Vlasova DD; Orlova KD; Rykova MP; Andersson J; Percipalle P; Kutter C; Ponomarev SA; Westerberg LS
Article: BRITISH JOURNAL OF CANCER. 2023;128(6):982-991

Increased cross-presentation by dendritic cells and enhanced anti-tumour therapy using the Arp2/3 inhibitor CK666.

Oliveira MMS; D'Aulerio R; Yong T; He M; Baptista MAP; Nylén S; Westerberg LS
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2022;111(4):793-803

The WASp L272P gain-of-function mutation alters dendritic cell coordination of actin dynamics for migration and adhesion.

Oliveira MMS; Kung S-Y; Moreau HD; Maurin M; Record J; Sanséau D; Nylén S; Lennon-Duménil A-M; Westerberg LS
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(3):1069-1084

Overactive WASp in X-linked neutropenia leads to aberrant B-cell division and accelerated plasma cell generation.

He M; Saeed MB; Record J; Keszei M; Gonçalves Pinho L; Vasconcelos-Fontes L; D'Aulerio R; Vieira R; Oliveira MMS; Geyer C; Bohaumilitzky L; Thiemann M; Deordieva E; Buedts L; Matias Lopes JP; Pershin D; Hammarström L; Xia Y; Zhao X; Cunningham-Rundles C; Thrasher AJ; Burns SO; Cotta-de-Almeida V; Liu C; Shcherbina A; Vandenberghe P; Westerberg LS
Article: JCI INSIGHT. 2021;6(6):e140273

Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells.

Kritikou JS; Oliveira MM; Record J; Saeed MB; Nigam SM; He M; Keszei M; Wagner AK; Brauner H; Sendel A; Sedimbi SK; Rentouli S; Lane DP; Snapper SB; Kärre K; Vandenberghe P; Orange JS; Westerberg LS
Article: HAEMATOLOGICA. 2020;105(5):1339-1350

An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma.

Record J; Sendel A; Kritikou JS; Kuznetsov NV; Brauner H; He M; Nagy N; Oliveira MMS; Griseti E; Haase CB; Dahlström J; Boddul S; Wermeling F; Thrasher AJ; Liu C; Andersson J; Claesson H-E; Winqvist O; Burns SO; Björkholm M; Westerberg LS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(9):4115-4131

Constitutive activation of WASp in X-linked neutropenia renders neutrophils hyperactive.

Keszei M; Record J; Kritikou JS; Wurzer H; Geyer C; Thiemann M; Drescher P; Brauner H; Köcher L; James J; He M; Baptista MA; Dahlberg CI; Biswas A; Lane DP; Song W; Pütsep K; Vandenberghe P; Snapper SB; Westerberg LS
Article: GENOME MEDICINE. 2017;9(1):91

Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells.

Kuznetsov NV; Almuzzaini B; Kritikou JS; Baptista MAP; Oliveira MMS; Keszei M; Snapper SB; Percipalle P; Westerberg LS
Article: NATURE COMMUNICATIONS. 2016;7:12175

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.

Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Liedén A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylén S; Westerberg LS

Immunbristsjukdomar – Lisa Westerbergs grupp

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