Genetiska och funktionella studier av B och T cellsreceptorer – Gunilla Karlsson Hedestams grupp

Publikationer

Utvalda publikationer

• Article: CELL REPORTS MEDICINE. 2024;5(6):101577

  Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies

  Sheward DJ; Pushparaj P; Das H; Greaney AJ; Kim C; Kim S; Hanke L; Hyllner E; Dyrdak R; Lee J; Dopico XC; Dosenovic P; Peacock TP; McInerney GM; Albert J; Corcoran M; Bloom JD; Murrell B; Hedestam GBK; Hallberg BM
• Review: CURRENT OPINION IN IMMUNOLOGY. 2024;87:102429

  Adaptive immune receptor germline gene variation Martin M Corcoran and Gunilla B Karlsson Hedestam

  Corcoran MM; Hedestam GBK
• Article: NPJ VACCINES. 2024;9(1):58

  Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

  Decamp AC; Corcoran MM; Fulp WJ; Willis JR; Cottrell CA; Bader DLV; Kalyuzhniy O; Leggat DJ; Cohen KW; Hyrien O; Menis S; Finak G; Ballweber-Fleming L; Srikanth A; Plyler JR; Rahaman F; Lombardo A; Philiponis V; Whaley RE; Seese A; Brand J; Ruppel AM; Hoyland W; Mahoney CR; Cagigi A; Taylor A; Brown DM; Ambrozak DR; Sincomb T; Mullen T-M; Maenza J; Kolokythas O; Khati N; Bethony J; Roederer M; Diemert D; Koup RA; Laufer DS; McElrath JM; McDermott AB; Hedestam GBK; Schief WR
• Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2024;13(5):e1508

  Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque

  Dopico XC; Guryleva M; Mandolesi M; Corcoran M; Coquet JM; Murrell B; Hedestam GBK
• Article: IMMUNOLOGY LETTERS. 2023;259:24-29

  Untangling associations between immunoglobulin genotypes, repertoires and function

  Dopico XC; Mandolesi M; Hedestam GBK
• Article: NATURE COMMUNICATIONS. 2023;14(1):2249

  Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages

  Chernyshev M; Sakharkar M; Connor RI; Dugan HL; Sheward DJ; Rappazzo CG; Stalmarck A; Forsell MNE; Wright PF; Corcoran M; Murrell B; Walker LM; Hedestam GKB
• Article: IMMUNITY. 2023;56(3):635-652.e6

  Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

  Corcoran M; Chernyshev M; Mandolesi M; Narang S; Kaduk M; Ye K; Sundling C; Farnert A; Kreslavsky T; Bernhardsson C; Larena M; Jakobsson M; Hedestam GBK
• Article: IMMUNITY. 2023;56(1):193-206.e7

  Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies

  Pushparaj P; Nicoletto A; Sheward DJ; Das H; Dopico XC; Vidakovics LP; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekstrom S; McInerney G; Hallberg BM; Murrell B; Corcoran M; Hedestam GBK
• Article: IMMUNITY. 2022;55(12):2405-2418.e7

  Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses

  Moin SM; Boyington JC; Boyoglu-Barnum S; Gillespie RA; Cerutti G; Cheung CS-F; Cagigi A; Gallagher JR; Brand J; Prabhakaran M; Tsybovsky Y; Stephens T; Fisher BE; Creanga A; Ataca S; Rawi R; Corbett KS; Crank MC; Hedestam GBK; Gorman J; McDermott AB; Harris AK; Zhou T; Kwong PD; Shapiro L; Mascola JR; Graham BS; Kanekiyo M
• Article: SCIENCE. 2022;378(6623):eadd6502

  Vaccination induces HIV broadly neutralizing antibody precursors in humans

  Leggat DJ; Cohen KW; Willis JR; Fulp WJ; deCamp AC; Kalyuzhniy O; Cottrell CA; Menis S; Finak G; Ballweber-Fleming L; Srikanth A; Plyler JR; Schiffner T; Liguori A; Rahaman F; Lombardo A; Philiponis V; Whaley RE; Seese A; Brand J; Ruppel AM; Hoyland W; Yates NL; Williams LD; Greene K; Gao H; Mahoney CR; Corcoran MM; Cagigi A; Taylor A; Brown DM; Ambrozak DR; Sincomb T; Hu X; Tingle R; Georgeson E; Eskandarzadeh S; Alavi N; Lu D; Mullen T-M; Kubitz M; Groschel B; Maenza J; Kolokythas O; Khati N; Bethony J; Crotty S; Roederer M; Hedestam GBK; Tomaras GD; Montefiori D; Diemert D; Koup RA; Laufer DS; McElrath MJ; McDermott AB; Schief WR
• Editorial comment: IMMUNITY. 2022;55(1):8-10

  A family matter: Anti-viral antibody responses

  Dopico XC; Hedestam GBK
• Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379

  Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates

  Dopico XC; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikstrom L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Hedestam GBK
• Article: PLOS PATHOGENS. 2021;17(9):e1009543

  Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization

  Aljedani SS; Liban TJ; Tran K; Phad G; Singh S; Dubrovskaya V; Pushparaj P; Martinez-Murillo P; Rodarte J; Mileant A; Prasad VM; Kinzelman R; O'Dell S; Mascola JR; Lee KK; Hedestam GBK; Wyatt RT; Pancera M
• Editorial comment: NATURE METHODS. 2021;18(6):588-591

  Diversity in immunogenomics: the value and the challenge

  Peng K; Safonova Y; Shugay M; Popejoy AB; Rodriguez OL; Breden F; Brodin P; Burkhardt AM; Bustamante C; Cao-Lormeau V-M; Corcoran MM; Duffy D; Fuentes-Guajardo M; Fujita R; Greiff V; Jonsson VD; Liu X; Quintana-Murci L; Rossetti M; Xie J; Yaari G; Zhang W; Abedalthagafi MS; Adekoya KO; Ahmed RA; Chang W-C; Gray C; Nakamura Y; Lees WD; Khatri P; Alachkar H; Scheepers C; Watson CT; Karlsson Hedestam GB; Mangul S
• Article: IMMUNITY. 2021;54(2):355-366.e4

  Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles

  Bernat NV; Corcoran M; Nowak I; Kaduk M; Dopico XC; Narang S; Maisonasse P; Dereuddre-Bosquet N; Murrell B; Hedestam GBK
• Article: NATURE COMMUNICATIONS. 2020;11(1):4420

  An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

  Hanke L; Perez LV; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GBK; Haellberg BM; Murrell B; McInerney GM
• Article: CELL HOST & MICROBE. 2020;27(4):531-543.e6

  VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing

  Shen C-H; DeKosky BJ; Guo Y; Xu K; Gu Y; Kilam D; Ko SH; Kong R; Liu K; Louder MK; Ou L; Zhang B; Chao CW; Corcoran MM; Feng E; Huang J; Normandin E; O'Dell S; Ransier A; Rawi R; Sastry M; Schmidt SD; Wang S; Wang Y; Chuang G-Y; Doria-Rose NA; Lin B; Zhou T; Boritz EA; Connors M; Douek DC; Hedestam GBK; Sheng Z; Shapiro L; Mascola JR; Kwong PD
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2020;217(2):e20191155

  Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses

  Phad GE; Pushparaj P; Tran K; Dubrovskaya V; Adori M; Martinez-Murillo P; Bernat NV; Singh S; Dionne G; O'Dell S; Bhullar K; Narang S; Sorini C; Villablanca EJ; Sundling C; Murrell B; Mascola JR; Shapiro L; Pancera M; Martin M; Corcoran M; Wyatt RT; Hedestam GBK
• Article: IMMUNITY. 2019;51(5):915-929.e7

  Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

  Dubrovskaya V; Tran K; Ozorowski G; Guenaga J; Wilson R; Bale S; Cottrell CA; Turner HL; Seabright G; O'Dell S; Torres JL; Yang L; Feng Y; Leaman DP; Bernat NV; Liban T; Louder M; McKee K; Bailer RT; Movsesyan A; Doria-Rose NA; Pancera M; Hedestam GBK; Zwick MB; Crispin M; Mascola JR; Ward AB; Wyatt RT
• Article: CELL. 2019;178(3):567-584.e19

  Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

  Kong R; Duan H; Sheng Z; Xu K; Acharya P; Chen X; Cheng C; Dingens AS; Gorman J; Sastry M; Shen C-H; Zhang B; Zhou T; Chuang G-Y; Chao CW; Gu Y; Jafari AJ; Louder MK; O'Dell S; Rowshan AP; Viox EG; Wang Y; Choi CW; Corcoran MM; Corrigan AR; Dandey VP; Eng ET; Geng H; Foulds KE; Guo Y; Kwon YD; Lin B; Liu K; Mason RD; Nason MC; Ohr TY; Ou L; Rawi R; Sarfo EK; Schoen A; Todd JP; Wang S; Wei H; Wu W; Mullikin JC; Bailer RT; Doria-Rose NA; Hedestam GBK; Scorpio DG; Overbaugh J; Bloom JD; Carragher B; Potter CS; Shapiro L; Kwong PD; Mascola JR
• Article: PLOS PATHOGENS. 2017;13(9):e1006614

  Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

  Dubrovskaya V; Guenaga J; de Val N; Wilson R; Feng Y; Movsesyan A; Hedestam GBK; Ward AB; Wyatt RT
• Article: IMMUNITY. 2017;46(5):804-817.e7

  Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

  Martinez-Murillo P; Tran K; Guenaga J; Lindgren G; Adori M; Feng Y; Phad GE; Bernat NV; Bale S; Ingale J; Dubrovskaya V; O'Dell S; Pramanik L; Spangberg M; Corcoran M; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
• Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196

  PPAR-γ promotes type 2 immune responses in allergy and nematode infection

  Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
• Article: NATURE COMMUNICATIONS. 2016;7:13642

  Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

  Corcoran MM; Phad GE; Bernat NV; Stahl-Hennig C; Sumida N; Persson MAA; Martin M; Hedestam GBK
• Article: IMMUNITY. 2015;43(2):318-330

  Interleukin-21-Producing CD4⁺ T Cells Promote Type 2 Immunity to House Dust Mites

  Coquet JM; Schuijs MJ; Smyth MJ; Deswarte K; Beyaert R; Braun H; Boon L; Hedestam GBK; Nutt SL; Hammad H; Lambrecht BN
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(39):E4119-E4126

  B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS

  Pedersen GK; Adori M; Khoenkhoen S; Dosenovic P; Beutler B; Hedestam GBK
• Article: PLOS PATHOGENS. 2014;10(8):e1004337

  HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization

  Navis M; Karen T; Bale S; Phad GE; Guenaga J; Wilson R; Soldemo M; McKee K; Sundling C; Mascola J; Li Y; Wyatt RT; Hedestam GBK
• Article: JOURNAL OF IMMUNOLOGY. 2014;192(8):3637-3644

  Single-Cell and Deep Sequencing of IgG-Switched Macaque B Cells Reveal a Diverse Ig Repertoire following Immunization

  Sundling C; Zhang Z; Phad GE; Sheng Z; Wang Y; Mascola JR; Li Y; Wyatt RT; Shapiro L; Hedestam GBK
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):E738-E747

  Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

  Tran K; Poulsen C; Guenaga J; de Val N; Wilson R; Sundling C; Li Y; Stanfield RL; Wilson IA; Ward AB; Hedestam GBK; Wyatt RT
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(142):142ra96

  High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site

  Sundling C; Li Y; Huynh N; Poulsen C; Wilson R; O'Dell S; Feng Y; Mascola JR; Wyatt RT; Hedestam GBK
• Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6018-6026

  BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses

  Dosenovic P; Soldemo M; Scholz JL; O'Dell S; Grasset EK; Pelletier N; Karlsson MCI; Mascola JR; Wyatt RT; Cancro MP; Hedestam GBK
• Corrigendum: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(10):2283

  Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates (vol 207, pg 2003, 2010)

  Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
• Article: PLOS PATHOGENS. 2008;4(10):e1000171

  B Cell Recognition of the Conserved HIV-1 Co-Receptor Binding Site Is Altered by Endogenous Primate CD4

  Forsell MNE; Dey B; Moerner A; Svehla K; O'dell S; Hoegerkorp C-M; Voss G; Thorstensson R; Shaw GM; Mascola JR; Hedestam GBK; Wyatt RT
• Review: NATURE REVIEWS MICROBIOLOGY. 2008;6(2):143-155

  The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.

  Karlsson Hedestam GB; Fouchier RAM; Phogat S; Burton DR; Sodroski J; Wyatt RT
• Visa fler

Alla gruppmedlemmars publikationer

• Article: IMMUNITY. 2025;58(6):1598-1613.e8

  Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer

  Schleich F-A; Bale S; Guenaga J; Ozorowski G; Adori M; Lin X; Dopico XC; Wilson R; Chernyshev M; Cotgreave AT; Mandolesi M; Cluff J; Doyle ED; Sewall LM; Lee W-H; Zhang S; O'Dell S; Healy BS; Lim D; Lewis VR; Ben-Akiva E; Irvine DJ; Doria-Rose NA; Corcoran M; Carnathan D; Silvestri G; Wilson IA; Ward AB; Hedestam GBK; Wyatt RT
• Article: SCIENCE. 2025;:eadv5572

  Precise targeting of HIV broadly neutralizing antibody precursors in humans.

  Caniels TG; Prabhakaran M; Ozorowski G; MacPhee KJ; Wu W; van der Straten K; Agrawal S; Derking R; Reiss EIMM; Millard K; Turroja M; Desrosiers A; Bethony J; Malkin E; Liesdek MH; van der Veen A; Klouwens M; Snitselaar JL; Bouhuijs JH; Bronson R; Jean-Baptiste J; Gajjala S; Rikhtegaran Tehrani Z; Benner A; Ramaswami M; Duff MO; Liu Y-W; Sato AH; Kim JY; Baken IJL; Mendes Silva C; Bijl TPL; van Rijswijk J; Burger JA; Cupo A; Yasmeen A; Phulera S; Lee W-H; Randall KN; Zhang S; Corcoran MM; Regadas I; Sullivan AC; Brown DM; Bohl JA; Greene KM; Gao H; Yates NL; Sawant S; Prins JM; Kootstra NA; Kaminsky SM; Barin B; Rahaman F; Meller M; Philiponis V; Laufer DS; Lombardo A; Mwoga L; Shotorbani S; Holman D; Koup RA; Klasse PJ; Karlsson Hedestam GB; Tomaras GD; van Gils MJ; Montefiori DC; McDermott AB; Hyrien O; Moore JP; Wilson IA; Ward AB; Diemert DJ; de Bree GJ; Andrews SF; Caskey M; Sanders RW
• Article: SCIENCE. 2025;:eadr8382

  Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans.

  Willis JR; Prabhakaran M; Muthui M; Naidoo A; Sincomb T; Wu W; Cottrell CA; Landais E; deCamp AC; Keshavarzi NR; Kalyuzhniy O; Lee JH; Murungi LM; Ogonda WA; Yates NL; Corcoran MM; Phulera S; Musando J; Tsai A; Lemire G; Sein Y; Muteti M; Alamuri P; Bohl JA; Holman D; Himansu S; Leav B; Reuter C; Lin L-A; Ding B; He C; Straus WL; MacPhee KJ; Regadas I; Nyabundi DV; Chirchir R; Anzala A; Kimotho JN; Kibet C; Greene K; Gao H; Beatman E; Benson K; Laddy D; Brown DM; Bronson R; Baptiste J; Gajjala S; Rikhtegaran-Tehrani Z; Benner A; Ramaswami M; Lu D; Alavi N; Amirzehni S; Kubitz M; Tingle R; Georgeson E; Phelps N; Adachi Y; Liguori A; Flynn C; McKenney K; Zhou X; Owuor DC; Owuor S; Kim S-Y; Duff M; Kim JY; Gibson G; Baboo S; Diedrich J; Schiffner T; Shields M; Matsoso M; Santos J; Syvertsen K; Kennedy A; Schroeter M; Vekemans J; Yates J; Paulson JC; Hyrien O; McDermott AB; Maenetje P; Nyombayire J; Karita E; Ingabire R; Edward V; Muturi-Kioi V; Maenza J; Shapiro AE; McElrath MJ; Edupuganti S; Taylor BS; Diemert D; Ozorowski G; Koup RA; Montefiori D; Ward AB; Hedestam GK; Tomaras G; Hunt DJ; Muema D; Sok D; Laufer DS; Andrews SF; Nduati EW; Schief WR
• Article: NATURE COMMUNICATIONS. 2025;16(1):4080

  T cell toxicity induced by tigecycline binding to the mitochondrial ribosome

  Shao Q; Khawaja A; Nguyen MD; Singh V; Zhang J; Liu Y; Nordin J; Adori M; Innis CA; Dopico XC; Rorbach J
• Preprint: BIORXIV. 2025

  Detection of PCR chimeras in adaptive immune receptor repertoire sequencing using hidden Markov models

  Chernyshev M; Stålmarck A; Corcoran M; Hedestam GBK; Murrell B
• Article: NPJ BREAST CANCER. 2025;11(1):19

  The Breast Cancer Classifier refines molecular breast cancer classification to delineate the HER2-low subtype.

  Turova P; Kushnarev V; Baranov O; Butusova A; Menshikova S; Yong ST; Nadiryan A; Antysheva Z; Khorkova S; Guryleva MV; Bagaev A; Lennerz JK; Chernyshov K; Kotlov N
• Article: CELL REPORTS. 2025;44(1):115221

  Antigen affinity and site of immunization dictate B cell recall responses

  Termote M; Marques RC; Hyllner E; V. Guryleva M; Henskens M; Brutscher A; Baken IJL; Dopico XC; Gasull AD; Murrell B; Stamatatos L; Westerberg LS; Dosenovic P
• Article: NUCLEIC ACIDS RESEARCH. 2025;53(3):gkaf025

  Simulation of adaptive immune receptors and repertoires with complex immune information to guide the development and benchmarking of AIRR machine learning

  Chernigovskaya M; Pavlovic M; Kanduri C; Gielis S; Robert PA; Scheffer L; Slabodkin A; Haff IH; Meysman P; Yaari G; Sandve GK; Greiff V
• Article: PLOS GLOBAL PUBLIC HEALTH. 2025;5(4):e0004364

  In danger: HIV vaccine research and development in Europe

  Tatoud R; Levy Y; Le Grand R; Alcami J; Barbareschi G; Brander C; Cara A; Combadiere B; Dabis F; Fidler S; Hanke T; Herrera C; Karlsson Hedestam GB; Kuipers H; Mccormack S; Moog C; Pantaleo G; Richert L; Sanders RW; Shattock R; Streeck H; Thiebaut R; Trkola A; Ueeberla K; Van Gills MJ; Wagner R; Weissenhorn W; Yazdanpanah Y; Scarlatti G; Lelievre JD
• Preprint: BIORXIV. 2024

  Generation of antigen-specific paired chain antibody sequences using large language models

  Wasdin PT; Johnson NV; Janke AK; Held S; Marinov TM; Jordaan G; Vandenabeele L; Pantouli F; Gillespie RA; Vukovich MJ; Holt CM; Kim J; Hansman G; Logue J; Chu HY; Andrews SF; Kanekiyo M; Sautto GA; Ross TM; Sheward DJ; McLellan JS; Abu-Shmais AA; Georgiev IS
• Article: CELL. 2024;187(25):7214-7231.e23

  Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques

  Wang H; Cheng C; Santo JLD; Shen C-H; Bylund T; Henry AR; Howe CA; Hwang J; Morano NC; Morris DJ; Pletnev S; Roark RS; Zhou T; Hansen BT; Hoyt FH; Johnston TS; Wang S; Zhang B; Ambrozak DR; Becker JE; Bender MF; Changela A; Chaudhary R; Corcoran M; Corrigan AR; Foulds KE; Guo Y; Lee M; Li Y; Lin BC; Liu T; Louder MK; Mandolesi M; Mason RD; Mckee K; Nair V; O'Dell S; Olia AS; Ou L; Pegu A; Raju N; Rawi R; Roberts-Torres J; Sarfo EK; Sastry M; Schaub AJ; Schmidt SD; Schramm CA; Schwartz CL; Smith SC; Stephens T; Stuckey J; Teng I-T; Todd J-P; Tsybovsky Y; Van Wazer DJ; Wang S; Doria-Rose NA; Fischer ER; Georgiev IS; Hedestam GBK; Sheng Z; Woodward RA; Douek DC; Koup RA; Pierson TC; Shapiro L; Shaw GM; Mascola JR; Kwong PD
• Article: IMMUNOGENETICS. 2024;77(1):6

  Novel polymorphic and copy number diversity in the antibody IGH locus of South African individuals

  Marsden AA; Corcoran M; Hedestam GK; Garrett N; Karim SSA; Moore PL; Kitchin D; Morris L; Scheepers C
• Preprint: BIORXIV. 2024

  Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases

  Chernigovskaya M; Quý KL; Stensland M; Singh S; Nelson R; Yilmaz M; Kalogeropoulos K; Sinitcyn P; Patel A; Castellana N; Bonissone S; Foss S; Andersen JT; Sandve GK; Jenkins TP; Noble WS; Nyman TA; Snapkow I; Greiff V
• Article: BRIEFINGS IN BIOINFORMATICS. 2024;25(6):bbae537

  Predictability of antigen binding based on short motifs in the antibody CDRH3

  Scheffer L; Reber EE; Mehta BB; Pavlovic M; Chernigovskaya M; Richardson E; Akbar R; Lund-Johansen F; Greiff V; Haff IH; Sandve GK
• Article: PLOS PATHOGENS. 2024;20(9):e1012499

  Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families

  Vukovich MJ; Shiakolas AR; Lindenberger J; Richardson RA; Bass LE; Barr M; Liu Y; Go EP; Park CS; May AJ; Sammour S; Kambarami C; Huang X; Janowska K; Edwards RJ; Mansouri K; Spence TN; Abu-Shmais AA; Manamela NP; Richardson SI; Leonard SEW; Gripenstraw KR; Setliff I; Saunders KO; Bonami RH; Ross TM; Desaire H; Moore PL; Parks R; Haynes BF; Sheward DJ; Acharya P; Sautto GA; Georgiev IS
• Article: COMMUNICATIONS BIOLOGY. 2024;7(1):922

  Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability.

  Bashour H; Smorodina E; Pariset M; Zhong J; Akbar R; Chernigovskaya M; Lê Quý K; Snapkow I; Rawat P; Krawczyk K; Sandve GK; Gutierrez-Marcos J; Gutierrez DN-Z; Andersen JT; Greiff V
• Article: NATURE COMMUNICATIONS. 2024;15(1):6338

  Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques

  Mandolesi M; Das H; de Vries L; Yang Y; Kim C; Dhinakaran M; Castro Dopico X; Fischbach J; Kim S; Guryleva MV; Adori M; Chernyshev M; Stalmarck A; Hanke L; Mcinerney GM; Sheward DJ; Corcoran M; Haellberg BM; Murrell B; Karlsson Hedestam GB
• Article: NPJ SYSTEMS BIOLOGY AND APPLICATIONS. 2024;10(1):73

  Benchmarking and integrating human B-cell receptor genomic and antibody proteomic profiling.

  Lê Quý K; Chernigovskaya M; Stensland M; Singh S; Leem J; Revale S; Yadin DA; Nice FL; Povall C; Minns DH; Galson JD; Nyman TA; Snapkow I; Greiff V
• Preprint: BIORXIV. 2024

  Training data composition determines machine learning generalization and biological rule discovery

  Ursu E; Minnegalieva A; Rawat P; Chernigovskaya M; Tacutu R; Sandve GK; Robert P; Greiff V
• Article: CELL REPORTS MEDICINE. 2024;5(6):101577

  Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies

  Sheward DJ; Pushparaj P; Das H; Greaney AJ; Kim C; Kim S; Hanke L; Hyllner E; Dyrdak R; Lee J; Dopico XC; Dosenovic P; Peacock TP; McInerney GM; Albert J; Corcoran M; Bloom JD; Murrell B; Hedestam GBK; Hallberg BM
• Review: CURRENT OPINION IN IMMUNOLOGY. 2024;87:102429

  Adaptive immune receptor germline gene variation Martin M Corcoran and Gunilla B Karlsson Hedestam

  Corcoran MM; Hedestam GBK
• Article: NPJ VACCINES. 2024;9(1):58

  Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

  Decamp AC; Corcoran MM; Fulp WJ; Willis JR; Cottrell CA; Bader DLV; Kalyuzhniy O; Leggat DJ; Cohen KW; Hyrien O; Menis S; Finak G; Ballweber-Fleming L; Srikanth A; Plyler JR; Rahaman F; Lombardo A; Philiponis V; Whaley RE; Seese A; Brand J; Ruppel AM; Hoyland W; Mahoney CR; Cagigi A; Taylor A; Brown DM; Ambrozak DR; Sincomb T; Mullen T-M; Maenza J; Kolokythas O; Khati N; Bethony J; Roederer M; Diemert D; Koup RA; Laufer DS; McElrath JM; McDermott AB; Hedestam GBK; Schief WR
• Preprint: RESEARCH SQUARE. 2024

  Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques

  Mandolesi M; Das H; de Vries L; Yang Y; Kim C; Dhinakaran M; Dopico XC; Fischbach J; Kim S; Guryleva M; Adori M; Chernyshev M; Stålmarck A; Hanke L; McInerney G; Sheward D; Corcoran M; Hällberg M; Murrell B; Hedestam GK
• Doctoral thesis: 2024

  Defining human adaptive immune gene diversity

  Narang S
• Letter: LANCET INFECTIOUS DISEASES. 2024;24(2):e80-e81

  Humoral immune responses to the monovalent XBB.1.5-adapted BNT162b2 mRNA booster in Sweden
• Article: NPJ VACCINES. 2024;9(1):17

  Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2

  Lenart K; Cerveira RA; Hellgren F; Ols S; Sheward DJ; Kim C; Cagigi A; Gagne M; Davis B; Germosen D; Roy V; Alter G; Letscher H; Van Wassenhove J; Gros W; Gallouet A-S; Le Grand R; Kleanthous H; Guebre-Xabier M; Murrell B; Patel N; Glenn G; Smith G; Lore K
• Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2024;13(5):e1508

  Maintenance of caecal homeostasis by diverse adaptive immune cells in the rhesus macaque

  Dopico XC; Guryleva M; Mandolesi M; Corcoran M; Coquet JM; Murrell B; Hedestam GBK
• Preprint: BIORXIV. 2023

  Humoral immune responses to the monovalent XBB.1.5-adapted BNT162b2 mRNA booster

  Marking U; Bladh O; Aguilera K; Yang Y; Norin NG; Blom K; Hober S; Klingström J; Havervall S; Åberg M; Sheward D; Thålin C
• Article: CELL REPORTS MEDICINE. 2023;4(11):101267

  SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes

  Wall SC; Suryadevara N; Kim C; Shiakolas AR; Holt CM; Irbe EB; Wasdin PT; Suresh YP; Binshtein E; Chen EC; Zost SJ; Canfield E; Crowe JEJ; Thompson-Arildsen MA; Sheward DJ; Carnahan RH; Georgiev IS
• Letter: LANCET INFECTIOUS DISEASES. 2023;23(11):e462-e463

  Sensitivity of the SARS-CoV-2 BA.2.86 variant to prevailing neutralising antibody responses

  Sheward DJ; Yang Y; Westerberg M; Oling S; Muschiol S; Sato K; Peacock TP; Hedestam GBK; Albert J; Murrell B
• Review: NATURE MICROBIOLOGY. 2023;8(11):1952-1959

  SARS-CoV-2 evolution in the Omicron era

  Roemer C; Sheward DJ; Hisner R; Gueli F; Sakaguchi H; Frohberg N; Schoenmakers J; Sato K; O'Toole A; Rambaut A; Pybus OG; Ruis C; Murrell B; Peacock TP
• Preprint: BIORXIV. 2023

  Simulation of adaptive immune receptors and repertoires with complex immune information to guide the development and benchmarking of AIRR machine learning

  Chernigovskaya M; Pavlović M; Kanduri C; Gielis S; Robert P; Scheffer L; Slabodkin A; Haff IH; Meysman P; Yaari G; Sandve GK; Greiff V
• Article: SCIENTIFIC REPORTS. 2023;13(1):17714

  Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq.

  Heimli M; Tennebø Flåm S; Sagsveen Hjorthaug H; Bjørnstad PM; Chernigovskaya M; Le QK; Tekpli X; Greiff V; Lie BA
• Article: IMMUNITY. 2023;56(10):2425-2441.e14

  Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses

  Ols S; Lenart K; Cerveira RA; Miranda MC; Brunette N; Kochmann J; Corcoran M; Skotheim R; Philomin A; Cagigi A; Fiala B; Wrenn S; Marcandalli J; Hellgren F; Thompson EA; Lin A; Gegenfurtner F; Kumar A; Chen M; Phad GE; Graham BS; Perez L; Borst AJ; Hedestam GBK; Ruckwardt TJ; King NP; Lore K
• Article: JCI INSIGHT. 2023;8(17):e167656

  Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations

  Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
• Preprint: BIORXIV. 2023

  Sensitivity of BA.2.86 to prevailing neutralising antibody responses

  Sheward D; Yang Y; Westerberg M; Öling S; Muschiol S; Sato K; Peacock T; Karlsson Hedestam G; Albert J; Murrell B
• Article: DEVELOPMENT. 2023;150(15):dev201548

  Separation of transcriptional repressor and activator functions in Drosophila HDAC3

  Tang M; Regadas I; Belikov S; Shilkova O; Xu L; Wernersson E; Liu X; Wu H; Bienko M; Mannervik M
• Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):4080

  Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses (vol 14, 3713, 2023)

  Hellgren F; Cagigi A; Cerveira RA; Ols S; Kern T; Lin A; Eriksson B; Dodds MG; Jasny E; Schwendt K; Freuling C; Mueller T; Corcoran M; Hedestam GKB; Petsch B; Lore K; Usa C
• Article: IMMUNOLOGY LETTERS. 2023;259:24-29

  Untangling associations between immunoglobulin genotypes, repertoires and function

  Dopico XC; Mandolesi M; Hedestam GBK
• Article: NATURE COMMUNICATIONS. 2023;14(1):3713

  Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses

  Hellgren F; Cagigi A; Cerveira RA; Ols S; Kern T; Lin A; Eriksson B; Dodds MG; Jasny E; Schwendt K; Freuling C; Mueller T; Corcoran M; Hedestam GBK; Petsch B; Lore K
• Article: IMMUNOINFORMATICS. 2023;10:100025

  AIRR community curation and standardised representation for immunoglobulin and T cell receptor germline sets.

  Lees WD; Christley S; Peres A; Kos JT; Corrie B; Ralph D; Breden F; Cowell LG; Yaari G; Corcoran M; Karlsson Hedestam GB; Ohlin M; Collins AM; Watson CT; Busse CE; AIRR Community
• Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2023;1524(1):65-86

  Progress in vaccine development for infectious diseases-a Keystone Symposia report

  Cable J; Graham BS; Koup RA; Seder RA; Kariko K; Pardi N; Barouch DH; Sharma B; Rauch S; Nachbagauer R; Forsell MNE; Schotsaert M; Ellebedy AH; Lore K; Irvine DJ; Pilkington E; Tahtinen S; Thompson EA; Feraoun Y; King NP; Saunders K; Alter G; Moin SM; Sliepen K; Karlsson Hedestam GB; Wardemann H; Pulendran B; Doria-Rose NA; He W-T; Juno JA; Ataca S; Wheatley AK; McLellan JS; Walker LM; Lederhofer J; Lindesmith LC; Wille H; Hotez PJ; Bekker L-G
• Article: LANCET REGIONAL HEALTH-EUROPE. 2023;30:100646

  Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study.

  Vikström L; Fjällström P; Gwon Y-D; Sheward DJ; Wigren-Byström J; Evander M; Bladh O; Widerström M; Molnar C; Rasmussen G; Bennet L; Åberg M; Björk J; Tevell S; Thålin C; Blom K; Klingström J; Murrell B; Ahlm C; Normark J; Johansson AF; Forsell MNE
• Article: OPEN BIOLOGY. 2023;13(5):220369

  Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH

  Schulte T; Panas MD; Han X; Williams L; Kedersha N; Fleck JS; Tan TJC; Dopico XC; Olsson A; Morro AM; Hanke L; Nilvebrant J; Giang KA; Nygren P-A; Anderson P; Achour A; McInerney GM
• Review: SEMINARS IN LIVER DISEASE. 2023;43(02):149-162

  Hepatic Innervations and Nonalcoholic Fatty Liver Disease

  Adori M; Bhat S; Gramignoli R; Valladolid-Acebes I; Bengtsson T; Uhlen M; Adori C
• Article: CELLS. 2023;12(9):1229

  Enhanced B Cell Receptor Signaling Partially Compensates for Impaired Toll-like Receptor 4 Responses in LPS-Stimulated IκBNS-Deficient B Cells

  Adori M; Khoenkhoen S; Zhang J; Dopico XC; Karlsson Hedestam GB
• Article: NATURE COMMUNICATIONS. 2023;14(1):2249

  Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages

  Chernyshev M; Sakharkar M; Connor RI; Dugan HL; Sheward DJ; Rappazzo CG; Stalmarck A; Forsell MNE; Wright PF; Corcoran M; Murrell B; Walker LM; Hedestam GKB
• Doctoral thesis: 2023

  Immunoglobulin gene usage and affinity maturation in antiviral antibodies

  Pushparaj P
• Article: EUROSURVEILLANCE. 2023;28(13):2200432

  At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study

  Bystrom JW; Vikstrom L; Rosendal E; Groning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Hedestam GBK; Thunberg T; Monsen T; Elgh F; Evander M; Johansson AF; Overby AK; Ahim C; Normark J; Forsell MNE
• Article: IMMUNITY. 2023;56(3):635-652.e6

  Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

  Corcoran M; Chernyshev M; Mandolesi M; Narang S; Kaduk M; Ye K; Sundling C; Farnert A; Kreslavsky T; Bernhardsson C; Larena M; Jakobsson M; Hedestam GBK
• Article: FRONTIERS IN VIROLOGY. 2023;3:1128253

  Frequent use of IGHV3-30-3 in SARS-CoV-2 neutralizing antibody responses

  Pushparaj P; Nicoletto A; Castro Dopico X; Sheward DJ; Kim S; Ekstrom S; Murrell B; Corcoran M; Karlsson Hedestam GB
• Journal article: BIOPHYSICAL JOURNAL. 2023;122(3):541a-542a

  Structural basis of antibodies targeting neutralizing epitopes revealed by cryoempem

  Zhang S; Ozorowski G; Antanasijevic A; van Schooten J; Richey S; Copps J; Hedestam GK; Sanders RW; Ward A
• Doctoral thesis: 2023

  Genetic and functional analysis of the adaptive immune response

  Mandolesi M
• Article: NUCLEIC ACIDS RESEARCH. 2023;51(2):891-907

  Translation initiation of leaderless and polycistronic transcripts in mammalian mitochondria

  Remes C; Khawaja A; Pearce SF; Dinan AM; Gopalakrishna S; Cipullo M; Kyriakidis V; Zhang J; Dopico XC; Yukhnovets O; Atanassov I; Firth AE; Cooperman B; Rorbach J
• Article: IMMUNITY. 2023;56(1):193-206.e7

  Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies

  Pushparaj P; Nicoletto A; Sheward DJ; Das H; Dopico XC; Vidakovics LP; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekstrom S; McInerney G; Hallberg BM; Murrell B; Corcoran M; Hedestam GBK
• Article: JCI INSIGHT. 2023;8(1):e165299

  Longitudinal single-cell analysis of SARS-CoV-2-reactive B cells uncovers persistence of early-formed, antigen-specific clones

  Scharf L; Axelsson H; Emmanouilidi A; Mathew NR; Sheward DJ; Leach S; Isakson P; Smirnov IV; Marklund E; Miron N; Andersson L-M; Gisslen M; Murrell B; Lundgren A; Bemark M; Angeletti D
• Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2023;10:1221620

  Application and challenges of TCR and BCR sequencing to investigate T- and B-cell clonality in elastase-induced experimental murine abdominal aortic aneurysm.

  Elster C; Ommer-Bläsius M; Lang A; Vajen T; Pfeiler S; Feige M; Yau Pang T; Böttenberg M; Verheyen S; Lê Quý K; Chernigovskaya M; Kelm M; Winkels H; Schmidt SV; Greiff V; Gerdes N
• Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1330153

  AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes

  Collins AM; Ohlin M; Corcoran M; Heather JM; Ralph D; Law M; Martinez-Barnetche J; Ye J; Richardson E; Gibson WS; Rodriguez OL; Peres A; Yaari G; Watson CT; Lees WD
• Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1073414

  Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity

  Hardt U; Corcoran MM; Narang S; Malmstrom V; Padyukov L; Hedestam GBK
• Article: FRONTIERS IN IMMUNOLOGY. 2023;14:941281

  SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses

  Christensen D; Polacek C; Sheward DJ; Hanke L; McInerney G; Murrell B; Hartmann KT; Jensen HE; Zimmermann J; Jungersen G; Illigen KE; Isling LK; Fernandez-Antunez C; Ramirez S; Bukh J; Pedersen GK
• Article: JOURNAL OF CANCER. 2023;14(16):3039-3049

  Synergistic Cytotoxicity of a Toxin Targeting the Epidermal Growth Factor Receptor and the Glycosylated Triterpenoid SO1861 in Prostate Cancer

  Fischer A; Masilamani AP; Schultze-Seemann S; Wolf I; Gratzke C; Fuchs H; Wolf P
• Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1125884

  Adaptive immune receptor genotyping using the corecount program

  Narang S; Kaduk M; Chernyshev M; Hedestam GBKB; Corcoran MM
• Article: MABS. 2022;14(1):2031482

  In silico proof of principle of machine learning-based antibody design at unconstrained scale

  Akbar R; Robert PA; Weber CR; Widrich M; Frank R; Pavlovic M; Scheffer L; Chernigovskaya M; Snapkov I; Slabodkin A; Mehta BB; Miho E; Lund-Johansen F; Andersen JT; Hochreiter S; Haff IH; Klambauer G; Sandve GK; Greiff V
• Article: GIGASCIENCE. 2022;12:giad074

  simAIRR: simulation of adaptive immune repertoires with realistic receptor sequence sharing for benchmarking of immune state prediction methods

  Kanduri C; Scheffer L; Pavlovic M; Rand KD; Chernigovskaya M; Pirvandy O; Yaari G; Greiff V; Sandve GK
• Article: IMMUNITY. 2022;55(12):2405-2418.e7

  Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses

  Moin SM; Boyington JC; Boyoglu-Barnum S; Gillespie RA; Cerutti G; Cheung CS-F; Cagigi A; Gallagher JR; Brand J; Prabhakaran M; Tsybovsky Y; Stephens T; Fisher BE; Creanga A; Ataca S; Rawi R; Corbett KS; Crank MC; Hedestam GBK; Gorman J; McDermott AB; Harris AK; Zhou T; Kwong PD; Shapiro L; Mascola JR; Graham BS; Kanekiyo M
• Article: SCIENCE. 2022;378(6623):eadd6502

  Vaccination induces HIV broadly neutralizing antibody precursors in humans

  Leggat DJ; Cohen KW; Willis JR; Fulp WJ; deCamp AC; Kalyuzhniy O; Cottrell CA; Menis S; Finak G; Ballweber-Fleming L; Srikanth A; Plyler JR; Schiffner T; Liguori A; Rahaman F; Lombardo A; Philiponis V; Whaley RE; Seese A; Brand J; Ruppel AM; Hoyland W; Yates NL; Williams LD; Greene K; Gao H; Mahoney CR; Corcoran MM; Cagigi A; Taylor A; Brown DM; Ambrozak DR; Sincomb T; Hu X; Tingle R; Georgeson E; Eskandarzadeh S; Alavi N; Lu D; Mullen T-M; Kubitz M; Groschel B; Maenza J; Kolokythas O; Khati N; Bethony J; Crotty S; Roederer M; Hedestam GBK; Tomaras GD; Montefiori D; Diemert D; Koup RA; Laufer DS; McElrath MJ; McDermott AB; Schief WR
• Article: NATURE COMPUTATIONAL SCIENCE. 2022;2(12):845-865

  Unconstrained generation of synthetic antibody-antigen structures to guide machine learning methodology for antibody specificity prediction.

  Robert PA; Akbar R; Frank R; Pavlović M; Widrich M; Snapkov I; Slabodkin A; Chernigovskaya M; Scheffer L; Smorodina E; Rawat P; Mehta BB; Vu MH; Mathisen IF; Prósz A; Abram K; Olar A; Miho E; Haug DTT; Lund-Johansen F; Hochreiter S; Haff IH; Klambauer G; Sandve GK; Greiff V
• Article: NPJ VACCINES. 2022;7(1):152

  Fine-mapping the immunodominant antibody epitopes on consensus sequence-based HIV-1 envelope trimer vaccine candidates

  Reiss EIMM; van Haaren MM; van Schooten J; Claireaux MAF; Maisonnasse P; Antanasijevic A; Allen JD; Bontjer I; Torres JL; Lee W-H; Ozorowski G; Bernat NV; Kaduk M; Aldon Y; Burger JA; Chawla H; Aartse A; Tolazzi M; Gao H; Mundsperger P; Crispin M; Montefiori DC; Hedestam GBK; Scarlatti G; Ward AB; Le Grand R; Shattock R; Dereuddre-Bosquet N; Sanders RW; van Gils MJ
• Preprint: RESEARCH SQUARE. 2022

  Vaccination of SARS-CoV-2-infected individuals expands a broad range of clonally diverse affinity-matured B cell lineages

  Chernyshev M; Sakharkar M; Connor R; Dugan H; Sheward D; Rappazzo G; Stålmarck A; Forsell M; Wright P; Corcoran M; Murrell B; Walker L; Hedestam GK
• Letter: LANCET INFECTIOUS DISEASES. 2022;22(11):1538-1540

  Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies

  Sheward DJ; Kim C; Fischbach J; Sato K; Muschiol S; Ehling RA; Bjorkstrom NK; Hedestam GBK; Reddy ST; Albert J; Peacock TP; Murrell B
• Article: EBIOMEDICINE. 2022;84:104248

  Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategy

  Christensen D; Polacek C; Sheward DJ; Hanke L; Moliner-Morro A; McInerney G; Murrell B; Hartmann KT; Jensen HE; Jungersen G; Illigen K; Isling LK; Jensen RF; Hansen JS; Rosenkrands I; Fernandez-Antunez C; Ramirez S; Follmann F; Bukh J; Pedersen GK
• Letter: LANCET INFECTIOUS DISEASES. 2022;22(10):1421-1422

  Evasion of neutralising antibodies by omicron sublineage BA.2.75

  Sheward DJ; Kim C; Fischbach J; Muschiol S; Ehling RA; Bjorkstrom NK; Hedestam GBK; Reddy ST; Albert J; Peacock TP; Murrell B
• Article: CANCERS. 2022;14(19):4663

  Investigation of the Role of PUFA Metabolism in Breast Cancer Using a Rank-Based Random Forest Algorithm.

  Guryleva MV; Penzar DD; Chistyakov DV; Mironov AA; Favorov AV; Sergeeva MG
• Preprint: BIORXIV. 2022

  Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies

  Sheward D; Kim C; Fischbach J; Muschiol S; Ehling R; Björkström N; Karlsson Hedestam G; Reddy S; Albert J; Peacock T; Murrell B
• Preprint: BIORXIV. 2022

  Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

  Corcoran M; Chernyshev M; Mandolesi M; Narang S; Kaduk M; Sundling C; Färnert A; Bernhardsson C; Larena M; Jakobsson M; Karlsson Hedestam G
• Article: JOURNAL OF VIROLOGY. 2022;96(14):e0032422-e00322

  HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies

  Sheward DJ; Hermanus T; Murrell B; Garrett N; Karim SSA; Morris L; Moore PL; Williamson C
• Preprint: BIORXIV. 2022

  Evasion of neutralizing antibodies by Omicron sublineage BA.2.75

  Sheward D; Kim C; Fischbach J; Muschiol S; Ehling R; Björkström N; Karlsson Hedestam G; Reddy S; Albert J; Peacock T; Murrell B
• Article: SCIENTIFIC REPORTS. 2022;12(1):11876

  Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis

  Hardt U; Carlberg K; af Klint E; Sahlstrom P; Larsson L; van Vollenhoven A; Machado SH; Israelsson L; Amara K; Chemin K; Korotkova M; Hedestam GBK; Catrina AI; Teichmann SA; Stahl PL; Malmstrom V
• Journal article: IMMUNOINFORMATICS. 2022;6:100012

  A Nextflow pipeline for T-cell receptor repertoire reconstruction and analysis from RNA sequencing data

  Rubio T; Chernigovskaya M; Marquez S; Marti C; Izquierdo-Altarejos P; Urios A; Montoliu C; Felipo V; Conesa A; Greiff V; Tarazona S
• Article: LANCET INFECTIOUS DISEASES. 2022;22(6):813-820

  Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study

  Sheward DJ; Kim C; Ehling RA; Pankow A; Dopico XC; Dyrdak R; Martin DP; Reddy ST; Dillner J; Hedestam GBK; Albert J; Murrell B
• Letter: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;95(6):e13161

  KiiM retreat 2021: Local immunology to fit global need?

  Mandolesi M; Rodahl I; Steiner L; Gronwall C; Smed-Sorensen A
• Article: GIGASCIENCE. 2022;11:giac046

  Profiling the baseline performance and limits of machine learning models for adaptive immune receptor repertoire classification

  Kanduri C; Pavlovic M; Scheffer L; Motwani K; Chernigovskaya M; Greiff V; Sandve GK
• Preprint: MEDRXIV. 2022;MEDRXIV

  Serological assessment of SARS-CoV-2 exposure in northern Sweden by the use of at-home sampling to meet geographical challenges in rural regions.

  Byström JW; Vikström L; Rosendal E; Gröning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Karlsson Hedestam GB; Thunberg T; Monsen T; Elgh F; Evander M; Johansson A; Överby AK; Ahlm C; Normark J; Forsell MN
• Article: CELLULAR IMMUNOLOGY. 2022;375:104516

  Impaired plasma cell differentiation associates with increased oxidative metabolism in I?BNS-deficient B cells

  Erikson E; Adori M; Khoenkhoen S; Zhang J; Rorbach J; Dopico XC; Hedestam GK
• Article: CANCERS. 2022;14(8):2041

  Multi-Omics Approach Points to the Importance of Oxylipins Metabolism in Early-Stage Breast Cancer.

  Chistyakov DV; Guryleva MV; Stepanova ES; Makarenkova LM; Ptitsyna EV; Goriainov SV; Nikolskaya AI; Astakhova AA; Klimenko AS; Bezborodova OA; Rasskazova EA; Potanina OG; Abramovich RA; Nemtsova ER; Sergeeva MG
• Review: TRENDS IN BIOTECHNOLOGY. 2022;40(4):463-481

  Progress and challenges in mass spectrometry-based analysis of antibody repertoires

  Snapkov I; Chernigovskaya M; Sinitcyn P; Khang LQ; Nyman TA; Greiff V
• Article: SCIENCE ADVANCES. 2022;8(12):eabm0220

  Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies

  Hanke L; Sheward DJ; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith NL; Astorga-Wells J; Ekstrom S; Coquet JM; McInerney GM; Murrell B
• Article: JOURNAL OF INFECTIOUS DISEASES. 2022;225(6):965-970

  Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms

  Cunningham JL; Virhammar J; Ronnberg B; Dopico XC; Kolstad L; Albinsson B; Kumlien E; Naas A; Klang A; Westman G; Zetterberg H; Frithiof R; Lundkvist A; Hedestam GBK; Rostami E
• Article: CELL REPORTS. 2022;38(3):110242

  SARS-CoV-2 reactive and neutralizing antibodies discovered by single-cell sequencing of plasma cells and mammalian display

  Ehling RA; Weber CR; Mason DM; Friedensohn S; Wagner B; Bieberich F; Kapetanovic E; Vazquez-Lombardi R; Di Roberto RB; Hong K-L; Wagner C; Pataia M; Overath MD; Sheward DJ; Murrell B; Yermanos A; Cuny AP; Savic M; Rudolf F; Reddy ST
• Preprint: BIORXIV. 2022

  A semi-supervised Bayesian mixture modelling approach for joint batch correction and classification

  Coleman S; Nicholls K; Nicholls K; Dopico XC; Karlsson Hedestam G; Kirk PDW; Wallace C
• Editorial comment: IMMUNITY. 2022;55(1):8-10

  A family matter: Anti-viral antibody responses

  Dopico XC; Hedestam GBK
• Article: NATURE COMMUNICATIONS. 2022;13(1):155

  A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

  Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM
• Preprint: BIORXIV. 2022

  Structural basis of Omicron neutralization by affinity-matured public antibodies

  Sheward D; Pushparaj P; Das H; Kim C; Kim S; Hanke L; Dyrdak R; McInerney G; Albert J; Murrell B; Karlsson Hedestam G; Hällberg M
• Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1000755

  IκBNS expression in B cells is dispensable for IgG responses to T cell-dependent antigens

  Khoenkhoen S; Adori M; Solis-Sayago D; Soulier J; Russell J; Beutler B; Pedersen GK; Hedestam GBK
• Article: FRONTIERS IN IMMUNOLOGY. 2022;13:888555

  A BALB/c IGHV Reference Set, Defined by Haplotype Analysis of Long-Read VDJ-C Sequences From F1 (BALB/c x C57BL/6) Mice

  Jackson KJL; Kos JT; Lees W; Gibson WS; Smith ML; Peres A; Yaari G; Corcoran M; Busse CE; Ohlin M; Watson CT; Collins AM
• Article: FRONTIERS IN IMMUNOLOGY. 2022;13:1026951

  Primary antibody response after influenza virus infection is first dominated by low-mutated HA-stem antibodies followed by higher-mutated HA-head antibodies

  Aartse A; Mortier D; Mooij P; Hofman S; van Haaren MM; Corcoran M; Karlsson Hedestam GB; Eggink D; Claireaux M; Bogers WMJM; van Gils MJ; Koopman G
• Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:1083232

  Silver nanoparticles with excellent biocompatibility block pseudotyped SARS-CoV-2 in the presence of lung surfactant

  Gupta G; Hamawandi B; Sheward DJ; Murrell B; Hanke L; McInerney G; Blosi M; Costa AL; Toprak MS; Fadeel B
• Review: JOURNAL OF INTERNAL MEDICINE. 2022;291(1):32-50

  Immunity to SARS-CoV-2 induced by infection or vaccination

  Castro Dopico X; Ols S; Lore K; Karlsson Hedestam GB
• Article: FRONTIERS IN IMMUNOLOGY. 2022;13:818440

  Addressing IGHV Gene Structural Diversity Enhances Immunoglobulin Repertoire Analysis: Lessons From Rhesus Macaque

  Kaduk M; Corcoran M; Hedestam GBK
• Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379

  Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates

  Dopico XC; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikstrom L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Hedestam GBK
• Preprint: BIORXIV. 2021

  Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)

  Sheward D; Kim C; Ehling R; Pankow A; Dopico XC; Martin D; Reddy S; Dillner J; Karlsson Hedestam G; Albert J; Murrell B
• Letter: GENES AND IMMUNITY. 2021;22(7-8):335-338

  Commentary on Population matched (pm) germline allelic variants of immunoglobulin (IG) loci: relevance in infectious diseases and vaccination studies in human populations

  Collins AM; Peres A; Corcoran MM; Watson CT; Yaari G; Lees WD; Ohlin M
• Article: GENOME RESEARCH. 2021;31(12):2209-2224

  Individualized VDJ recombination predisposes the available Ig sequence space

  Slabodkin A; Chernigovskaya M; Mikocziova I; Akbar R; Scheffer L; Pavlovic M; Bashour H; Snapkov I; Mehta BB; Weber CR; Gutierrez-Marcos J; Sollid LM; Haff IH; Sandve GK; Robert PA; Greiff V
• Article: CELL REPORTS MEDICINE. 2021;2(11):100450

  Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models

  Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith NL; Dopico XC; McInerney GM; Coquet JM; Hedestam GBK; Murrell B
• Article: NATURE MACHINE INTELLIGENCE. 2021;3(11):936-944

  The immuneML ecosystem for machine learning analysis of adaptive immune receptor repertoires

  Pavlovic M; Scheffer L; Motwani K; Kanduri C; Kompova R; Vazov N; Waagan K; Bernal FLM; Costa AA; Corrie B; Akbar R; Al Hajj GS; Balaban G; Brusko TM; Chernigovskaya M; Christley S; Cowell LG; Frank R; Grytten I; Gundersen S; Haff IH; Hovig E; Hsieh P-H; Klambauer G; Kuijjer ML; Lund-Andersen C; Martini A; Minotto T; Pensar J; Rand K; Riccardi E; Robert PA; Rocha A; Slabodkin A; Snapkov I; Sollid LM; Titov D; Weber CR; Widrich M; Yaari G; Greiff V; Sandve GK
• Preprint: MEDRXIV. 2021

  Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

  Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
• Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):666-676

  Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden

  Castro Dopico X; Muschiol S; Christian M; Hanke L; Sheward DJ; Grinberg NF; Rorbach J; Bogdanovic G; Mcinerney GM; Allander T; Wallace C; Murrell B; Albert J; Karlsson Hedestam GB
• Article: PLOS PATHOGENS. 2021;17(9):e1009543

  Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization

  Aljedani SS; Liban TJ; Tran K; Phad G; Singh S; Dubrovskaya V; Pushparaj P; Martinez-Murillo P; Rodarte J; Mileant A; Prasad VM; Kinzelman R; O'Dell S; Mascola JR; Lee KK; Hedestam GBK; Wyatt RT; Pancera M
• Preprint: MEDRXIV. 2021

  Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis

  Hardt U; Carlberg K; Klint EA; Sahlström P; Larsson L; van Vollenhoven A; Machado SH; Israelsson L; Amara K; Chemin K; Korotkova M; Hedestam GBK; Catrina AI; Teichmann SA; Ståhl PL; Malmström V
• Article: ANTICANCER RESEARCH. 2021;41(8):3741-3746

  Epidermal Growth Factor Based Targeted Toxin for the Treatment of Bladder Cancer

  Masilamani AP; Fischer A; Schultze-Seemann S; Kuckuck I; Wolf I; Dressler FF; Gratzke C; Wolf P
• Article: METABOLITES. 2021;11(8):498

  Modulation of the Primary Astrocyte-Enriched Cultures' Oxylipin Profiles Reduces Neurotoxicity.

  Guryleva MV; Chistyakov DV; Lopachev AV; Goriainov SV; Astakhova AA; Timoshina YA; Khutorova AV; Fedorova TN; Sergeeva MG
• Preprint: BIORXIV. 2021

  Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralising SARS-CoV-2 nanobodies

  Hanke L; Sheward D; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith N; Astorga-Wells J; Ekström S; Coquet J; McInerney G; Murrell B
• Editorial comment: NATURE METHODS. 2021;18(6):588-591

  Diversity in immunogenomics: the value and the challenge

  Peng K; Safonova Y; Shugay M; Popejoy AB; Rodriguez OL; Breden F; Brodin P; Burkhardt AM; Bustamante C; Cao-Lormeau V-M; Corcoran MM; Duffy D; Fuentes-Guajardo M; Fujita R; Greiff V; Jonsson VD; Liu X; Quintana-Murci L; Rossetti M; Xie J; Yaari G; Zhang W; Abedalthagafi MS; Adekoya KO; Ahmed RA; Chang W-C; Gray C; Nakamura Y; Lees WD; Khatri P; Alachkar H; Scheepers C; Watson CT; Karlsson Hedestam GB; Mangul S
• Article: EBIOMEDICINE. 2021;68:103429

  TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood

  Amoriello R; Chernigovskaya M; Greiff V; Carnasciali A; Massacesi L; Barilaro A; Repice AM; Biagioli T; Aldinucci A; Muraro PA; Laplaud DA; Lossius A; Ballerini C
• Article: CELL REPORTS MEDICINE. 2021;2(4):100252

  SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses

  Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
• Article: MOLECULAR CELL. 2021;81(8):1766-1780.e10

  A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation.

  Regadas I; Dahlberg O; Vaid R; Ho O; Belikov S; Dixit G; Deindl S; Wen J; Mannervik M
• Preprint: BIORXIV. 2021

  Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization

  Aljedani SS; Liban TJ; Tran K; Phad G; Singh S; Dubrovskaya V; Pushparaj P; Martinez-Murillo P; Rodarte J; Mileant A; Prasad VM; Kinzelman R; O’Dell S; Mascola JR; Lee KK; Hedestam GBK; Wyatt RT; Pancera M
• Preprint: BIORXIV. 2021

  Driving potent neutralization of a SARS-CoV-2 Variant of Concern with a heterotypic boost

  Sheward D; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith N; Dopico XC; McInerney G; Coquet J; Hedestam GK; Murrell B
• Preprint: BIORXIV. 2021

  A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

  Hanke L; Das H; Sheward D; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith N; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen G; Coquet J; Hällberg M; Murrell B; McInerney G
• Article: JOURNAL OF IMMUNOLOGY. 2021;206(5):999-1012

  Polyfunctional Tier 2-Neutralizing Antibodies Cloned following HIV-1 Env Macaque Immunization Mirror Native Antibodies in a Human Donor

  Spencer DA; Malherbe DC; Bernat NV; Adori M; Goldberg B; Dambrauskas N; Henderson H; Pandey S; Cheever T; Barnette P; Sutton WF; Ackerman ME; Kobie JJ; Sather DN; Hedestam GBK; Haigwood NL; Hessell AJ
• Preprint: BIORXIV. 2021

  Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2

  Ehling R; Weber C; Mason D; Friedensohn S; Wagner B; Bieberich F; Kapetanovic E; Vazquez-Lombardi R; Di Roberto R; Hong K-L; Wagner C; Sheward D; Murrell B; Yermanos A; Cuny A; Savic M; Rudolf F; Reddy S
• Article: IMMUNITY. 2021;54(2):355-366.e4

  Rhesus and cynomolgus macaque immunoglobulin heavy-chain genotyping yields comprehensive databases of germline VDJ alleles

  Bernat NV; Corcoran M; Nowak I; Kaduk M; Dopico XC; Narang S; Maisonasse P; Dereuddre-Bosquet N; Murrell B; Hedestam GBK
• Article: SCIENTIFIC REPORTS. 2021;11(1):3125

  DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice

  Szurgot I; Hanke L; Sheward DJ; Vidakovics LP; Murrell B; McInerney GM; Liljestrom P
• Review: JOURNAL OF BIOLOGICAL RHYTHMS. 2021;36(1):35-54

  Drivers of Infectious Disease Seasonality: Potential Implications for COVID-19

  Kronfeld-Schor N; Stevenson TJ; Nickbakhsh S; Schernhammer ES; Dopico XC; Dayan T; Martinez M; Helm B
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51(2):445-458

  Mast cells crosstalk with B cells in the gut and sustain IgA response in the inflamed intestine

  Valeri V; Tonon S; Vibhushan S; Gulino A; Belmonte B; Adori M; Karlsson Hedestam GB; Gautier G; Tripodo C; Blank U; Mion F; Pucillo CEM
• Article: IMMUNOLOGY AND CELL BIOLOGY. 2021;99(2):234-243

  GPR43 regulates marginal zone B-cell responses to foreign and endogenous antigens

  Rohrbeck L; Adori M; Wang S; He C; Tibbitt CA; Chernyshev M; Sirel M; Ribacke U; Murrell B; Bohlooly-Y M; Karlsson MCI; Karlsson Hedestam GB; Coquet JM
• Preprint: SSRN. 2021

  Single-Cell Sequencing of Plasma Cells from COVID-19 Patients Reveals Highly Expanded Clonal Lineages Produce Specific and Neutralizing Antibodies to SARS-CoV-2

  Ehling R; Weber C; Mason D; Friedensohn S; Wagner B; Bieberich F; Kapetanovic E; Vazquez-Lombardi R; Roberto RBD; Hong K-L; Wagner C; Sheward D; Murrel B; Yermanos A; Cuny A; Savic M; Rudolf F; Reddy S
• Article: EBIOMEDICINE. 2021;63:103197

  Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice

  Worzner K; Sheward DJ; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Hedestam GBK; Murrell B; Christensen D; Pedersen GK
• Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1312

  Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay

  Hober S; Hellstrom C; Olofsson J; Andersson E; Bergstrom S; Jernbom Falk A; Bayati S; Mravinacova S; Sjoberg R; Yousef J; Skoglund L; Kanje S; Berling A; Svensson A-S; Jensen G; Enstedt H; Afshari D; Xu LL; Zwahlen M; von Feilitzen K; Hanke L; Murrell B; McInerney G; Karlsson Hedestam GB; Lendel C; Roth RG; Skoog I; Svenungsson E; Olsson T; Fogdell-Hahn A; Lindroth Y; Lundgren M; Maleki KT; Lagerqvist N; Klingstrom J; Da Silva Rodrigues R; Muschiol S; Bogdanovic G; Arroyo Muhr LS; Eklund C; Lagheden C; Dillner J; Sivertsson A; Havervall S; Thalin C; Tegel H; Pin E; Manberg A; Hedhammar M; Nilsson P
• Article: FRONTIERS IN IMMUNOLOGY. 2021;12:815680

  VDJ Gene Usage in IgM Repertoires of Rhesus and Cynomolgus Macaques

  Chernyshev M; Kaduk M; Corcoran M; Hedestam GBK
• Preprint: MEDRXIV. 2020

  Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden

  Dopico XC; Muschiol S; Christian M; Hanke L; Sheward D; Grinberg N; Rorbach J; Bogdanovic G; Mcinerney G; Allander T; Wallace C; Murrell B; Albert J; Hedestam GK
• Article: BIOMOLECULES. 2020;10(12):E1661-1661

  Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs

  Moliner-Morro A; J. Sheward D; Karl V; Perez Vidakovics L; Murrell B; McInerney GM; Hanke L
• Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):6360

  Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells.

  Huang D; Tran JT; Olson A; Vollbrecht T; Tenuta M; Guryleva MV; Fuller RP; Schiffner T; Abadejos JR; Couvrette L; Blane TR; Saye K; Li W; Landais E; Gonzalez-Martin A; Schief W; Murrell B; Burton DR; Nemazee D; Voss JE
• Preprint: BIORXIV. 2020

  Estimating the timing of HIV infection from unmutated sequences

  Pankow A; Christian M; Smith N; Sheward D; Murrell B
• Article: NATURE COMMUNICATIONS. 2020;11(1):5850

  Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

  Huang D; Tran JT; Olson A; Vollbrecht T; Tenuta M; Guryleva MV; Fuller RP; Schiffner T; Abadejos JR; Couvrette L; Blane TR; Saye K; Li W; Landais E; Gonzalez-Martin A; Schief W; Murrell B; Burton DR; Nemazee D; Voss JE
• Article: NATURE COMMUNICATIONS. 2020;11(1):5588

  Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

  Custodio TF; Das H; Sheward DJ; Hanke L; Pazicky S; Pieprzyk J; Sorgenfrei M; Schroer MA; Gruzinov AY; Jeffries CM; Graewert MA; Svergun DI; Dobrev N; Remans K; Seeger MA; McInerney GM; Murrell B; Haellberg BM; Loew C
• Article: TOXINS. 2020;12(12):E753-753

  Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer

  Fischer A; Wolf I; Fuchs H; Masilamani AP; Wolf P
• Article: NATURE COMMUNICATIONS. 2020;11(1):4420

  An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

  Hanke L; Perez LV; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GBK; Haellberg BM; Murrell B; McInerney GM
• Preprint: BIORXIV. 2020

  SARS-CoV-2 protein subunit vaccination elicits potent neutralizing antibody responses

  Mandolesi M; Sheward D; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Loré K; Castro Dopico X; Coquet J; McInerney G; Karlsson Hedestam G; Murrell B
• Preprint: MEDRXIV. 2020

  Probabilistic approaches for classifying highly variable anti-SARS-CoV-2 antibody responses

  Dopico X; Hanke L; Sheward D; Muschiol S; Aleman S; Grinberg N; Adori M; Christian M; Vidakovics LP; Kim C; Khoenkhoen S; Pushparaj P; Morro AM; Mandolesi M; Ahl M; Forsell M; Coquet J; Corcoran M; Rorbach J; Dillner J; Bogdanovic G; McInerney G; Allander T; Murrell B; Wallace C; Albert J; Karlsson Hedestam G
• Preprint: BIORXIV. 2020

  Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

  Custódio T; Das H; Sheward D; Hanke L; Pazicky S; Pieprzyk J; Sorgenfrei M; Schroer M; Gruzinov A; Jeffries C; Graewert M; Svergun D; Dobrev N; Remans K; Seeger M; McInerney G; Murrell B; Hällberg M; Löw C
• Preprint: BIORXIV. 2020

  An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction

  Hanke L; Perez LV; Sheward D; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GK; Hällberg M; Murrell B; McInerney G
• Article: CELL HOST & MICROBE. 2020;27(4):531-543.e6

  VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing

  Shen C-H; DeKosky BJ; Guo Y; Xu K; Gu Y; Kilam D; Ko SH; Kong R; Liu K; Louder MK; Ou L; Zhang B; Chao CW; Corcoran MM; Feng E; Huang J; Normandin E; O'Dell S; Ransier A; Rawi R; Sastry M; Schmidt SD; Wang S; Wang Y; Chuang G-Y; Doria-Rose NA; Lin B; Zhou T; Boritz EA; Connors M; Douek DC; Hedestam GBK; Sheng Z; Shapiro L; Mascola JR; Kwong PD
• Article: CELL REPORTS. 2020;30(12):3964-3971.e7

  Route of Vaccine Administration Alters Antigen Trafficking but Not Innate or Adaptive Immunity

  Ols S; Yang L; Thompson EA; Pushparaj P; Tran K; Liang F; Lin A; Eriksson B; Hedestam GBK; Wyatt RT; Lore K
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2020;217(2):e20191155

  Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses

  Phad GE; Pushparaj P; Tran K; Dubrovskaya V; Adori M; Martinez-Murillo P; Bernat NV; Singh S; Dionne G; O'Dell S; Bhullar K; Narang S; Sorini C; Villablanca EJ; Sundling C; Murrell B; Mascola JR; Shapiro L; Pancera M; Martin M; Corcoran M; Wyatt RT; Hedestam GBK
• Article: NUCLEIC ACIDS RESEARCH. 2020;48(D1):D964-D970

  OGRDB: a reference database of inferred immune receptor genes

  Lees W; Busse CE; Corcoran M; Ohlin M; Scheepers C; Matsen FA; Yaari G; Watson CT; Collins A; Shepherd AJ
• Preprint: SSRN ELECTRONIC JOURNAL. 2020

  Rhesus and Cynomolgus IGH Genotyping Yields Comprehensive Databases of Germline VDJ Alleles for In-Depth Immunological Studies

  Bernat NV; Corcoran M; Nowak I; Kaduk M; Dopico XC; Narang S; Maisonasse P; Dereuddre-Bosquet N; Murrell B; Hedestam GBK
• Preprint: SSRN. 2020

  Adjuvanted SARS-CoV-2 Spike Protein Elicits Neutralizing Antibodies and CD4 T Cell Responses after a Single Immunization in Mice

  Wørzner K; Sheward D; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Hedestam GK; Murrel B; Christensen D; Pedersen G
• Article: FRONTIERS IN IMMUNOLOGY. 2020;11:571321

  Flow Cytometry-Based Protocols for the Analysis of Human Plasma Cell Differentiation

  Khoenkhoen S; Adori M; Pedersen GK; Hedestam GBK
• Article: IMMUNITY. 2019;51(5):915-929.e7

  Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

  Dubrovskaya V; Tran K; Ozorowski G; Guenaga J; Wilson R; Bale S; Cottrell CA; Turner HL; Seabright G; O'Dell S; Torres JL; Yang L; Feng Y; Leaman DP; Bernat NV; Liban T; Louder M; McKee K; Bailer RT; Movsesyan A; Doria-Rose NA; Pancera M; Hedestam GBK; Zwick MB; Crispin M; Mascola JR; Ward AB; Wyatt RT
• Article: BMC BIOINFORMATICS. 2019;20(1):523

  Domainoid: domain-oriented orthology inference.

  Persson E; Kaduk M; Forslund SK; Sonnhammer ELL
• Article: CELL. 2019;178(3):567-584.e19

  Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

  Kong R; Duan H; Sheng Z; Xu K; Acharya P; Chen X; Cheng C; Dingens AS; Gorman J; Sastry M; Shen C-H; Zhang B; Zhou T; Chuang G-Y; Chao CW; Gu Y; Jafari AJ; Louder MK; O'Dell S; Rowshan AP; Viox EG; Wang Y; Choi CW; Corcoran MM; Corrigan AR; Dandey VP; Eng ET; Geng H; Foulds KE; Guo Y; Kwon YD; Lin B; Liu K; Mason RD; Nason MC; Ohr TY; Ou L; Rawi R; Sarfo EK; Schoen A; Todd JP; Wang S; Wei H; Wu W; Mullikin JC; Bailer RT; Doria-Rose NA; Hedestam GBK; Scorpio DG; Overbaugh J; Bloom JD; Carragher B; Potter CS; Shapiro L; Kwong PD; Mascola JR
• Journal article: JOURNAL OF IMMUNOLOGY. 2019;202(1_Supplement):72.9

  Characterization of heterologous HIV-1 Tier 2 neutralizing mAbs cloned from a macaque immunized with viral quasispecies present in a human subject with neutralization breadth

  Spencer DA; Malherbe DC; Henderson H; Pandy S; Bernat NV; Àdori M; Goldberg B; Dambrauskas N; Sutton W; Sather N; Kobie J; Ackerman ME; Karlsson Hedestam GB; Haigwood NL; Hessell AJ
• Article: IMMUNOLOGY AND CELL BIOLOGY. 2019;97(5):485-497

  TACI expression and plasma cell differentiation are impaired in the absence of functional IκBNS

  Khoenkhoen S; Erikson E; Adori M; Stark JM; Scholz JL; Cancro MP; Pedersen GK; Hedestam GBK
• Article: METHODS IN MOLECULAR BIOLOGY. 2019;1910:469-504

  Evolution of Protein Domain Architectures.

  Forslund SK; Kaduk M; Sonnhammer ELL
• Conference publication: JOURNAL OF MEDICAL PRIMATOLOGY. 2019;48(5):301

  Native HIV-1 Env circulating during the development of breadth in human subjects elicits Tier 2 heterologous neutralizing monoclonal antibodies in macaques

  Spencer D; Malherbe D; Henderson H; Pandey S; Adori M; Bernat N; Kobie J; Karlsson-Hedestam G; Haigwood N; Hessell A
• Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2606

  Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp⁶²⁰ Risk Allele Drive the Expansion of FOXP3⁺ Regulatory T Cells and PD-1 Expression

  Ferreira RC; Dopico XC; Oliveira JJ; Rainbow DB; Yang JH; Trzupek D; Todd SA; McNeill M; Steri M; Orru V; Fiorillo E; Crouch DJM; Pekalski ML; Cucca F; Tree TI; Vyse TJ; Wicker LS; Todd JA
• Review: FRONTIERS IN IMMUNOLOGY. 2019;10:435

  Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming

  Ohlin M; Scheepers C; Corcoran M; Lees WD; Busse CE; Bagnara D; Thornqvist L; Burckert J-P; Jackson KJL; Ralph D; Schramm CA; Marthandan N; Breden F; Scott J; Matsen FA; Greiff V; Yaari G; Kleinstein SH; Christley S; Sherkow JS; Kossida S; Lefranc M-P; van Zelm MC; Watson CT; Collins AM
• Article: FRONTIERS IN IMMUNOLOGY. 2019;10:660

  High-Quality Library Preparation for NGS-Based Immunoglobulin Germline Gene Inference and Repertoire Expression Analysis

  Bernat NV; Corcoran M; Hardt U; Kaduk M; Phad GE; Martin M; Hedestam GBK
• Article: CELL HOST & MICROBE. 2018;24(4):593-599.e3

  HIV Superinfection Drives De Novo Antibody Responses and Not Neutralization Breadth

  Sheward DJ; Marais J; Bekker V; Murrell B; Eren K; Bhiman JN; Nonyane M; Garrett N; Woodman ZL; Karim QA; Karim SSA; Morris L; Moore PL; Williamson C
• Article: JCI INSIGHT. 2018;3(5):97018

  Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site

  Cheng HD; Grimm SK; Gilman MSA; Gwom LC; Sok D; Sundling C; Donofrio G; Hedestam GBK; Bonsignori M; Haynes BF; Lahey TP; Maro I; von Reyn CF; Gorny MK; Zolla-Pazner S; Walker BD; Alter G; Burton DR; Robb ML; Krebs SJ; Seaman MS; Bailey-Kellogg C; Ackerman ME
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2018;10(425):eaam6354

  Integrin α₄β₇ expression on peripheral blood CD4⁺ T cells predicts HIV acquisition and disease progression outcomes

  Sivro A; Schuetz A; Sheward D; Joag V; Yegorov S; Liebenberg LJ; Yende-Zuma N; Stalker A; Mwatelah RS; Selhorst P; Garrett N; Samsunder N; Balgobin A; Nawaz F; Cicala C; Arthos J; Fauci AS; Anzala AO; Kimani J; Bagaya BS; Kiwanuka N; Williamson C; Kaul R; Passmore J-AS; Phanuphak N; Ananworanich J; Ansari A; Karim QA; Karim SSA; McKinnon LR
• Article: JOURNAL OF IMMUNOLOGY. 2018;200(2):775-787

  Altered Marginal Zone B Cell Selection in the Absence of IκBNS

  Adori M; Pedersen GK; Adori C; Erikson E; Khoenkhoen S; Stark JM; Choi JH; Dosenovic P; Karlsson MCI; Beutler B; Hedestam GBK
• Article: NUCLEIC ACIDS RESEARCH. 2018;46(D1):D601-D607

  FunCoup 4: new species, data, and visualization.

  Ogris C; Guala D; Sonnhammer ELL
• Article: NATURE COMMUNICATIONS. 2018;9(1):7

  Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction.

  Jabs F; Plum M; Laursen NS; Jensen RK; Mølgaard B; Miehe M; Mandolesi M; Rauber MM; Pfützner W; Jakob T; Möbs C; Andersen GR; Spillner E
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2018;34:37

  Native HIV-1 Env Circulating During the Development of Breadth in Human Subjects Elicits Tier 2 Heterologous Neutralizing Monoclonal Antibodies in NHP

  Hessell A; Malherbe D; Henderson H; Pandey S; Adori M; Vazquez N; Kobie J; Karlsson-Hedestam G; Haigwood N
• Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1738

  B-1a cell Development in splenectomized neonatal Mice

  Pedersen GK; Li X; Khoenkhoen S; Adori M; Beutler B; Hedestam GBK
• Article: JOURNAL OF AUTOIMMUNITY. 2017;84:75-86

  Cells with Treg-specific &ITFOXP3&IT demethylation but low CD25 are prevalent in autoimmunity

  Ferreira RC; Simons HZ; Thompson WS; Rainbow DB; Yang X; Cutler AJ; Oliveira J; Dopico XC; Smyth DJ; Savinykh N; Mashar M; Vyse TJ; Dunge DB; Baxendale H; Chandra A; Wallace C; Todd JA; Wicker LS; Pekalski ML
• Article: JOURNAL OF VIROLOGY. 2017;91(21):e00910-e00917

  HIV-1 Cross-Reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Nonhuman Primates

  Wang Y; O'Dell S; Turner HL; Chiang C-I; Lei L; Guenaga J; Wilson R; Martinez-Murillo P; Doria-Rose N; Ward AB; Mascola JR; Wyatt RT; Hedestam GBK; Li Y
• Article: GENOME BIOLOGY. 2017;18(1):165

  Chromosome contacts in activated T cells identify autoimmune disease candidate genes

  Burren OS; Garcia AR; Javierre B-M; Rainbow DB; Cairns J; Cooper NJ; Lambourne JJ; Schofield E; Dopico XC; Ferreira RC; Coulson R; Burden F; Rowlston SP; Downes K; Wingett SW; Frontini M; Ouwehand WH; Fraser P; Spivakov M; Todd JA; Wicker LS; Cutler AJ; Wallace C
• Journal article: PLOS PATHOGENS. 2017;13(9):e1006641

  Correction: Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization.

  Rademeyer C; Korber B; Seaman MS; Giorgi EE; Thebus R; Robles A; Sheward DJ; Wagh K; Garrity J; Carey BR; Gao H; Greene KM; Tang H; Bandawe GP; Marais JC; Diphoko TE; Hraber P; Tumba N; Moore PL; Gray GE; Kublin J; McElrath MJ; Vermeulen M; Middelkoop K; Bekker L-G; Hoelscher M; Maboko L; Makhema J; Robb ML; Karim SA; Karim QA; Kim JH; Hahn BH; Gao F; Swanstrom R; Morris L; Montefiori DC; Williamson C
• Article: PLOS PATHOGENS. 2017;13(9):e1006614

  Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

  Dubrovskaya V; Guenaga J; de Val N; Wilson R; Feng Y; Movsesyan A; Hedestam GBK; Ward AB; Wyatt RT
• Article: JCI INSIGHT. 2017;2(16):93739

  Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2

  Pekalski ML; Garcia AR; Ferreira RC; Rainbow DB; Smyth DJ; Mashar M; Brady J; Savinykh N; Dopico XC; Mahmood S; Duley S; Stevens HE; Walker NM; Cutler AJ; Waldron-Lynch F; Dunger DB; Shannon-Lowe C; Coles AJ; Jones JL; Wallace C; Todd JA; Wicker LS
• Article: HYPERTENSION. 2017;70(3):HYPERTENSIONAHA.117.09242-633

  Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome

  Coan PM; Barrier M; Alfazema N; Carter RN; de Proce SM; Dopico XC; Diaz AG; Thomson A; Jackson-Jones LH; Moyon B; Webster Z; Ross D; Moss J; Arends MJ; Morton NM; Aitman TJ
• Article: IMMUNITY. 2017;46(5):804-817.e7

  Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

  Martinez-Murillo P; Tran K; Guenaga J; Lindgren G; Adori M; Feng Y; Phad GE; Bernat NV; Bale S; Ingale J; Dubrovskaya V; O'Dell S; Pramanik L; Spangberg M; Corcoran M; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
• Article: BIOINFORMATICS. 2017;33(8):1154-1159

  Improved orthology inference with Hieranoid 2.

  Kaduk M; Sonnhammer E
• Article: SCIENCE IMMUNOLOGY. 2017;2(9):eaal5196

  PPAR-γ promotes type 2 immune responses in allergy and nematode infection

  Chen T; Tibbitt CA; Feng X; Stark JM; Rohrbeck L; Rausch L; Sedimbi SK; Karlsson MCI; Lambrecht BN; Hedestam GBK; Hendriks RW; Chambers BJ; Nylen S; Coquet JM
• Article: NUCLEIC ACIDS RESEARCH. 2017;45(D1):D687-D690

  HieranoiDB: a database of orthologs inferred by Hieranoid.

  Kaduk M; Riegler C; Lemp O; Sonnhammer ELL
• Review: FRONTIERS IN IMMUNOLOGY. 2017;8:1057

  Env-Specific Antibodies in Chronic Infection versus in Vaccination

  Soldemo M; Hedestam GBK
• Journal article: PLOS PATHOGENS. 2017;13(1):e1006074

  Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape

  Wibmer CK; Gorman J; Ozorowski G; Bhiman JN; Sheward DJ; Elliott DH; Rouelle J; Smira A; Joyce MG; Ndabambi N; Druz A; Asokan M; Burton DR; Connors M; Karim SSA; Mascola JR; Robinson JE; Ward AB; Williamson C; Kwong PD; Morris L; Moore PL
• Review: IMMUNOLOGICAL REVIEWS. 2017;275(1):183-202

  Evolution of B cell analysis and Env trimer redesign

  Hedestam GBK; Guenaga J; Corcoran M; Wyatt RT
• Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1654

  Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice

  Soldemo M; Adori M; Stark JM; Feng Y; Tran K; Wilson R; Yang L; Guenaga J; Wyatt RT; Hedestam GBK
• Article: NATURE COMMUNICATIONS. 2016;7:13642

  Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity

  Corcoran MM; Phad GE; Bernat NV; Stahl-Hennig C; Sumida N; Persson MAA; Martin M; Hedestam GBK
• Article: PLOS PATHOGENS. 2016;12(7):e1005742

  Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive Immunization

  Rademeyer C; Korber B; Seaman MS; Giorgi EE; Thebus R; Robles A; Sheward DJ; Wagh K; Garrity J; Carey BR; Gao H; Greene KM; Tang H; Bandawe GP; Marais JC; Diphoko TE; Hraber P; Tumba N; Moore PL; Gray GE; Kublin J; McElrath MJ; Vermeulen M; Middelkoop K; Bekker L-G; Hoelscher M; Maboko L; Makhema J; Robb ML; Karim SA; Karim QA; Kim JH; Hahn BH; Gao F; Swanstrom R; Morris L; Montefiori DC; Williamson C
• Article: JOURNAL OF VIROLOGY. 2016;90(10):5031-5046

  Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds

  Madani N; Princiotto AM; Easterhoff D; Bradley T; Luo K; Williams WB; Liao H-X; Moody MA; Phad GE; Bernat NV; Melillo B; Santra S; Smith ABIII; Hedestam GBK; Haynes B; Sodroski J
• Article: JOURNAL OF IMMUNOLOGY. 2016;196(9):3729-3743

  High-Resolution Longitudinal Study of HIV-1 Env Vaccine-Elicited B Cell Responses to the Virus Primary Receptor Binding Site Reveals Affinity Maturation and Clonal Persistence

  Wang Y; Sundling C; Wilson R; O'Dell S; Chen Y; Dai K; Phad GE; Zhu J; Xiao Y; Mascola JR; Hedestam GBK; Wyatt RT; Li Y
• Article: SCIENTIFIC REPORTS. 2016;6:20987

  HIV-1 Vaccine-elicited Antibodies Reverted to Their Inferred Naive Germline Reveal Associations between Binding Affinity and in vivo Activation

  Dai K; Khan SN; Wang Y; He L; Guenaga J; Ingale J; Sundling C; O'Dell S; McKee K; Phad G; Corcoran M; Wilson R; Mascola JR; Zhu J; Li Y; Hedestam GBK; Wyatt RT
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:261

  Features of Recently Transmitted HIV-1 Clade C Viruses That Impact Antibody Recognition: Implications for Active and Passive Immunization

  Rademeyer C; Korber B; Seaman MS; Giorgi EE; Thebus R; Robles A; Sheward DJ; Wagh K; Garrity J; Carey BR; Gao H; Tang H; Bandawe GP; Hraber P; Tumba N; Moore PL; Morris L; Montefiori DC; Williamson C
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:46

  Hypo-osmolar Formulation of TFV Enemas Promotes Uptake and Transformation of TFV to TFV-DP in Tissues and Prevents SHIV/SIV Infection

  Xiao P; Gumber S; Marzinke M; Ensign L; Fuchs E; Hendrix C; Villinger F
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:60

  HIV-1 Superinfection Can Lead to Potent Neutralization of the Superinfecting Virus but Is Not Sufficient to Elicit Broadly Neutralizing Antibodies

  Sheward DJ; Nonyane M; Marais J; Bhiman JN; Garrett N; Karim SA; Woodman ZL; Morris L; Moore PL; Williamson C
• Article: FRONTIERS IN IMMUNOLOGY. 2016;7:65

  Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens

  Pedersen GK; Adori M; Stark JM; Khoenkhoen S; Arnold C; Beutler B; Hedestam GBK
• Article: FRONTIERS IN IMMUNOLOGY. 2016;7:242-10

  CD138 and CD31 Double-Positive Cells Comprise the Functional Antibody-Secreting Plasma Cell compartment in Primate Bone Marrow

  Martinez-Murillo P; Pramanik L; Sundling C; Hultenby K; Wretenberg P; Spangberg M; Hedestam GBK
• Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2015;1362:39-47

  NF-κB signaling in B-1 cell development

  Pedersen GK; Adori M; Hedestam GBK
• Article: MBIO. 2015;6(6):e01375-e01315

  Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis

  Dai K; He L; Khan SN; O'Dell S; McKee K; Tran K; Li Y; Sundling C; Morris CD; Mascola JR; Hedestam GBK; Wyatt RT; Zhu J
• Article: JOURNAL OF INFECTIOUS DISEASES. 2015;212(6):904-908

  HIV-1 Superinfection Resembles Primary Infection

  Sheward DJ; Ntale R; Garrett NJ; Woodman ZL; Karim SSA; Williamson C
• Article: IMMUNITY. 2015;43(2):318-330

  Interleukin-21-Producing CD4⁺ T Cells Promote Type 2 Immunity to House Dust Mites

  Coquet JM; Schuijs MJ; Smyth MJ; Deswarte K; Beyaert R; Braun H; Boon L; Hedestam GBK; Nutt SL; Hammad H; Lambrecht BN
• Journal article: RETROVIROLOGY. 2015;12:54

  South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication

  Richardson SI; Gray ES; Mkhize NN; Sheward DJ; Lambson BE; Wibmer CK; Masson L; Werner L; Garrett N; Passmore J-AS; Karim QA; Karim SSA; Williamson C; Moore PL; Morris L
• Article: JOURNAL OF IMMUNOLOGY. 2015;194(12):5903-5914

  Diverse Antibody Genetic and Recognition Properties Revealed following HIV-1 Envelope Glycoprotein Immunization

  Phad GE; Bernat NV; Feng Y; Ingale J; Murillo PAM; O'Dell S; Li Y; Mascola JR; Sundling C; Wyatt RT; Hedestam GBK
• Article: NATURE COMMUNICATIONS. 2015;6:7000

  Widespread seasonal gene expression reveals annual differences in human immunity and physiology

  Dopico XC; Evangelou M; Ferreira RC; Guo H; Pekalski ML; Smyth DJ; Cooper N; Burren OS; Fulford AJ; Hennig BJ; Prentice AM; Ziegler A-G; Bonifacio E; Wallace C; Todd JA
• Journal article: JOURNAL OF INFECTIOUS DISEASES. 2015;211(9):1461-1466

  Differences in HIV Type 1 Neutralization Breadth in 2 Geographically Distinct Cohorts in Africa

  Bandawe GP; Moore PL; Werner L; Gray ES; Sheward DJ; Madiga M; Nofemela A; Thebus R; Marais JC; Maboko L; Karim SSA; Hoelscher M; Morris L; Williamson C
• Article: JOURNAL OF IMMUNOLOGY. 2015;194(9):4422-4430

  Protection of Human Myeloid Dendritic Cell Subsets against Influenza A Virus Infection Is Differentially Regulated upon TLR Stimulation

  Baharom F; Thomas S; Bieder A; Hellmer M; Volz J; Sandgren KJ; McInerney GM; Hedestam GBK; Mellman I; Smed-Sorensen A
• Article: DIABETOLOGIA. 2015;58(4):781-790

  IL-21 production by CD4⁺ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

  Ferreira RC; Simons HZ; Thompson WS; Cutler AJ; Dopico XC; Smyth DJ; Mashar M; Schuilenburg H; Walker NM; Dunger DB; Wallace C; Todd JA; Wicker LS; Pekalski ML
• Article: SCIENTIFIC REPORTS. 2015;5:8925

  Primate immune responses to HIV-1 Env formulated in the saponin-based adjuvant AbISCO-100 in the presence or absence of TLR9 co-stimulation

  Martinez P; Sundling C; O'Dell S; Mascola JR; Wyatt RT; Hedestam GBK
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(5):E440-E449

  Real-time resolution of point mutations that cause phenovariance in mice

  Wang T; Zhan X; Bu C-H; Lyon S; Pratt D; Hildebrand S; Choi JH; Zhang Z; Zeng M; Wang K-W; Turer E; Chen Z; Zhang D; Yue T; Wang Y; Shi H; Wang J; Sun L; SoRelle J; McAlpine W; Hutchins N; Zhan X; Fina M; Gobert R; Quan J; Kreutzer M; Arnett S; Hawkins K; Leach A; Tate C; Daniel C; Reyna C; Prince L; Davis S; Purrington J; Bearden R; Weatherly J; White D; Russell J; Sun Q; Tang M; Li X; Scott L; Moresco EMY; McInerney GM; Hedestam GBK; Xie Y; Beutler B
• Article: NEW PHYTOLOGIST. 2015;205(3):1288-1295

  Transgenic hybrid aspen trees with increased gibberellin (GA) concentrations suggest that GA acts in parallel with FLOWERING LOCUS T2 to control shoot elongation.

  Eriksson ME; Hoffman D; Kaduk M; Mauriat M; Moritz T
• Article: IMMUNOLOGY AND CELL BIOLOGY. 2015;93(2):136-146

  Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation

  Dosenovic P; Adori M; Adams WC; Pedersen GK; Soldemo M; Beutler B; Hedestam GBK
• Corrigendum: JOURNAL OF VIROLOGY. 2015;89(1):887

  Robust Neutralizing Antibodies Elicited by HIV-1 JRFL Envelope Glycoprotein Trimers in Nonhuman Primates (vol 87, pg 13239, 2013)

  Chakrabarti BK; Feng Y; Sharma SK; Mckee K; Hedestam GBK; LaBranche CC; Montefiori DC; Mascola JR; Wyatt RT
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2014;211(12):2361-2372

  Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants

  Klein F; Nogueira L; Nishimura Y; Phad G; West APJ; Halper-Stromberg A; Horwitz JA; Gazumyan A; Liu C; Eisenreich TR; Lehmann C; Faetkenheuer G; Williams C; Shingai M; Martin MA; Bjorkman PJ; Seaman MS; Zolla-Pazner S; Hedestam GBK; Nussenzweig MC
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A34

  Maturation of Broadly Neutralizing V1V2-directed Antibodies in the Context of Autologous Viral Escape

  Bhiman JN; Doria-Rose NA; Wibmer CK; Sheward DJ; Williamson C; Karim SSA; Kwong PD; Mascola JR; Morris L; Moore PL
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A56

  The Sequence of the α4β7-binding Motif on Gp120 of Transmitted/Founder Viruses Contributes to the Dependence on the Integrin for HIV Infection

  Richardson SI; Gray E; Mkhize N; Sheward D; Lambson B; Wibmer K; Masson L; Werner L; Garett N; Passmore J-A; Abdool-Karim S; Williamson C; Moore P; Morris L
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A226

  Outgrowth of Subtype C Envelope Viral Populations in Dual-infected Individuals Is Not Always Associated with Entry Efficiency

  Omar SSA; Sheward D; Williamson C; Woodman Z
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A225

  Changes in Viral Population Kinetics Following HIV-1 Superinfection

  Logan MG; Sheward DJ; Anthony C; Garret N; Williamson C
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30:A20-A21

  Viral Escape Pathways from Broadly Neutralising Antibodies Targeting the HIV Envelope Cleavage Site Enhance MPER Mediated Neutralisation

  Wibmer CK; Sheward DJ; Bhiman JN; Ndabambi N; Elliot DH; Rouelle J; Smira A; Karim SSA; Robinson JE; Morris L; Williamson C; Moore PL
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(39):E4119-E4126

  B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS

  Pedersen GK; Adori M; Khoenkhoen S; Dosenovic P; Beutler B; Hedestam GBK
• Article: VIRUSES-BASEL. 2014;6(9):3400-3414

  HIV-1 Env-Specific Memory and Germinal Center B Cells in C57BL/6 Mice

  Soldemo M; Pedersen GK; Hedestam GBK
• Article: PLOS PATHOGENS. 2014;10(8):e1004337

  HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization

  Navis M; Karen T; Bale S; Phad GE; Guenaga J; Wilson R; Soldemo M; McKee K; Sundling C; Mascola J; Li Y; Wyatt RT; Hedestam GBK
• Article: NATURE COMMUNICATIONS. 2014;5:4557

  AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion

  Mojallal M; Zheng Y; Hultin S; Audebert S; van Harn T; Johnsson P; Lenander C; Fritz N; Mieth C; Corcoran M; Lembo F; Hallstroem M; Hartman J; Mazure NM; Weide T; Grander D; Borg J-P; Uhlen P; Holmgren L
• Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2014;177(3):571-585

  Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

  Thompson WS; Pekalski ML; Simons HZ; Smyth DJ; Castro-Dopico X; Guo H; Guy C; Dunger DB; Arif S; Peakman M; Wallace C; Wicker LS; Todd JA; Ferreira RC
• Article: PLOS GENETICS. 2014;10(6):e1004390

  Glycogen Synthase Kinase (GSK) 3β Phosphorylates and Protects Nuclear Myosin 1c from Proteasome-Mediated Degradation to Activate rDNA Transcription in Early G1 Cells

  Sarshad AA; Corcoran M; Al-Muzzaini B; Borgonovo-Brandter L; Von Euler A; Lamont D; Visa N; Percipalle P
• Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2014;408:137-141

  A simple and safe technique for longitudinal bone marrow aspiration in cynomolgus and rhesus macaques

  Spangberg M; Martinez P; Fredlund H; Hedestam GBK; Sundling C
• Conference publication: JOURNAL OF IMMUNOLOGY. 2014;192:131.5

  Potentially neutralizing B cell clonotypes are eliminated at peripheral selection checkpoints

  Scholz J; Soldemo M; Dosenovic P; Naradikiani M; Zhou L; Wilson R; Wyatt R; Lackner A; Hedestam GK; Cancro M
• Article: NATURE. 2014;509(7498):55-62

  Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

  Doria-Rose NA; Schramm CA; Gorman J; Moore PL; Bhiman JN; DeKosky BJ; Ernandes MJ; Georgiev IS; Kim HJ; Pancera M; Staupe RP; Altae-Tran HR; Bailer RT; Crooks ET; Cupo A; Druz A; Garrett NJ; Hoi KH; Kong R; Louder MK; Longo NS; McKee K; Nonyane M; O'Dell S; Roark RS; Rudicell RS; Schmidt SD; Sheward DJ; Soto C; Wibmer CK; Yang Y; Zhang Z; Mullikin JC; Binley JM; Sanders RW; Wilson IA; Moore JP; Ward AB; Georgiou G; Williamson C; Karim SSA; Morris L; Kwong PD; Shapiro L; Mascola JR
• Article: JOURNAL OF IMMUNOLOGY. 2014;192(8):3637-3644

  Single-Cell and Deep Sequencing of IgG-Switched Macaque B Cells Reveal a Diverse Ig Repertoire following Immunization

  Sundling C; Zhang Z; Phad GE; Sheng Z; Wang Y; Mascola JR; Li Y; Wyatt RT; Shapiro L; Hedestam GBK
• Article: JOURNAL OF VIROLOGY. 2014;88(6):3235-3245

  T Cells Modulate Epstein-Barr Virus Latency Phenotypes during Infection of Humanized Mice

  Heuts F; Rottenberg ME; Salamon D; Rasul E; Adori M; Klein G; Klein E; Nagy N
• Article: JOURNAL OF CLINICAL MICROBIOLOGY. 2014;52(3):844-848

  Limited HIV-1 Superinfection in Seroconverters from the CAPRISA 004 Microbicide Trial

  Redd AD; Mullis CE; Wendel SK; Sheward D; Martens C; Bruno D; Werner L; Garrett NJ; Karim QA; Williamson C; Porcella SF; Quinn TC; Karim SSA
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):E738-E747

  Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

  Tran K; Poulsen C; Guenaga J; de Val N; Wilson R; Sundling C; Li Y; Stanfield RL; Wilson IA; Ward AB; Hedestam GBK; Wyatt RT
• Article: IMMUNOLOGY. 2014;141(2):181-191

  Recognition of new citrulline-containing peptide epitopes by autoantibodies produced in vivo and in vitro by B cells of rheumatoid arthritis patients.

  Szarka E; Babos F; Magyar A; Huber K; Szittner Z; Papp K; Prechl J; Pozsgay J; Neer Z; Ádori M; Nagy G; Rojkovich B; Gáti T; Kelemen J; Baka Z; Brózik M; Pazár B; Poór G; Hudecz F; Sármay G
• Letter: AIDS. 2014;28(1):142-144

  Response to 'single genome amplification and sequencing methods require appropriate thresholds for viral transmission and evolution studies'

  Abrahams M-R; Sheward D; Williamson C
• Article: JOURNAL OF VIROLOGY. 2013;87(24):13239-13251

  Robust Neutralizing Antibodies Elicited by HIV-1 JRFL Envelope Glycoprotein Trimers in Nonhuman Primates

  Chakrabarti BK; Feng Y; Sharma SK; McKee K; Hedestam GBK; LaBranche CC; Montefiori DC; Mascola JR; Wyatt RT
• Article: VIROLOGY JOURNAL. 2013;10:347

  Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

  Lacerda M; Moore PL; Ngandu NK; Seaman M; Gray ES; Murrell B; Krishnamoorthy M; Nonyane M; Madiga M; Wibmer CK; Sheward D; Bailer RT; Gao H; Greene KM; Karim SSA; Mascola JR; Korber BTM; Montefiori DC; Morris L; Williamson C; Seoighe C
• Article: VIROLOGY. 2013;446(1-2):56-65

  Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants

  Feng Y; Forsell MNE; Flynn B; Adams W; Lore K; Seder R; Wyatt RT; Hedestam GBK
• Article: CELLULAR MICROBIOLOGY. 2013;15(8):1385-1400

  Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae

  Kuri T; Sorensen AS; Thomas S; Hedestam GBK; Normark S; Henriques-Normark B; McInerney GM; Plant L
• Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):44-51

  Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization

  Forsell MNE; Soldemo M; Dosenovic P; Wyatt RT; Karlsson MCI; Hedestam GBK
• Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):60-69

  Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation

  Sandgren KJ; Smed-Sorensen A; Forsell MN; Soldemo M; Adams WC; Liang F; Perbeck L; Koup RA; Wyatt RT; Hedestam GBK; Lore K
• Article: MOLECULAR BIOLOGY AND EVOLUTION. 2013;30(5):1196-1205

  FUBAR: A Fast, Unconstrained Bayesian AppRoximation for Inferring Selection

  Murrell B; Moola S; Mabona A; Weighill T; Sheward D; Pond SLK; Scheffler K
• Article: JOURNAL OF VIROLOGY. 2013;87(9):4882-4894

  Multiple Pathways of Escape from HIV Broadly Cross-Neutralizing V2-Dependent Antibodies

  Moore PL; Sheward D; Nonyane M; Ranchobe N; Hermanus T; Gray ES; Karim SSA; Williamson C; Morris L
• Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2013;31(5):1003-1010

  MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor δ in human monocytes during the inflammatory response

  Thulin P; Wei T; Werngren O; Cheung L; Fisher RM; Grander D; Corcoran M; Ehrenborg E
• Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2013;20(4):440-446

  A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells

  Johnsson P; Ackley A; Vidarsdottir L; Lui W-O; Corcoran M; Grander D; Morris KV
• Article: JOURNAL OF IMMUNOLOGY. 2013;190(6):2554-2566

  Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors

  Pekalski ML; Ferreira RC; Coulson RMR; Cutler AJ; Guo H; Smyth DJ; Downes K; Dendrou CA; Dopico XC; Esposito L; Coleman G; Stevens HE; Nutland S; Walker NM; Guy C; Dunger DB; Wallace C; Tree TIM; Todd JA; Wicker LS
• Article: JOURNAL OF INFECTIOUS DISEASES. 2013;207(3):426-431

  Immunization of Macaques With Soluble HIV Type 1 and Influenza Virus Envelope Glycoproteins Results in a Similarly Rapid Contraction of Peripheral B-Cell Responses After Boosting

  Sundling C; Martinez P; Soldemo M; Spangberg M; Bengtsson KL; Stertman L; Forsell MNE; Hedestam GBK
• Article: MOLECULAR BIOLOGY OF THE CELL. 2012;23(24):4701-4712

  Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection

  Panas MD; Varjak M; Lulla A; Eng KE; Merits A; Hedestam GBK; McInerney GM
• Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;386(1-2):85-93

  Isolation of antibody V(D)J sequences from single cell sorted rhesus macaque B cells

  Sundling C; Phad G; Douagi I; Navis M; Hedestam GBK
• Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;385(1-2):60-70

  Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cells

  Rasul AE; Nagy N; Sohlberg E; Adori M; Claesson H-E; Klein G; Klein E
• Article: NATURE MEDICINE. 2012;18(11):1688-1692

  Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape

  Moore PL; Gray ES; Wibmer CK; Bhiman JN; Nonyane M; Sheward DJ; Hermanus T; Bajimaya S; Tumba NL; Abrahams M-R; Lambson BE; Ranchobe N; Ping L; Ngandu N; Karim QA; Karim SSA; Swanstrom RI; Seaman MS; Williamson C; Morris L
• Article: LEUKEMIA & LYMPHOMA. 2012;53(10):2041-2050

  Involvement of miR17 pathway in glucocorticoid-induced cell death in pediatric acute lymphoblastic leukemia

  Harada M; Pokrovskaja-Tamm K; Soderhall S; Heyman M; Grander D; Corcoran M
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(31):12286-12293

  A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity

  Arnold CN; Pirie E; Dosenovic P; McInerney GM; Xia Y; Wang N; Li X; Siggs OM; Hedestam GBK; Beutler B
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(142):142ra96

  High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site

  Sundling C; Li Y; Huynh N; Poulsen C; Wilson R; O'Dell S; Feng Y; Mascola JR; Wyatt RT; Hedestam GBK
• Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6018-6026

  BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses

  Dosenovic P; Soldemo M; Scholz JL; O'Dell S; Grasset EK; Pelletier N; Karlsson MCI; Mascola JR; Wyatt RT; Cancro MP; Hedestam GBK
• Article: JOURNAL OF GENERAL VIROLOGY. 2012;93(Pt 6):1339-1344

  Attenuation of CD4⁺ T-cell function by human adenovirus type 35 is mediated by the knob protein

  Adams WC; Berenson RJ; Hedestam GBK; Lieber A; Koup RA; Lore K
• Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(21):E1330

  Degenerate Primer IDs and the Birthday Problem

  Sheward DJ; Murrell B; Williamson C
• Article: JOURNAL OF VIROLOGY. 2012;86(10):5674-5685

  Accumulation of Autophagosomes in Semliki Forest Virus-Infected Cells Is Dependent on Expression of the Viral Glycoproteins

  Eng KE; Panas MD; Murphy D; Hedestam GBK; McInerney GM
• Article: JOURNAL OF VIROLOGY. 2012;86(8):4701-4707

  Latency Type-Dependent Modulation of Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Expression by Type I Interferons in B Cells

  Salamon D; Adori M; Ujvari D; Wu L; Kis LL; Madapura HS; Nagy N; Klein G; Klein E
• Article: CYTOKINE. 2012;57(3):360-371

  Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells: Differential regulation in B cell lines derived from endemic or sporadic Burkitt's lymphoma

  Salmon D; Adori M; He M; Bonelt P; Severinson E; Kis LL; Wu L; Ujvari D; Leveau B; Nagy N; Klein G; Klein E
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(8):5673-5686

  Biochemically Defined HIV-1 Envelope Glycoprotein Variant Immunogens Display Differential Binding and Neutralizing Specificities to the CD4-binding Site

  Feng Y; Mckee K; Tran K; O'Dell S; Schmidt SD; Phogat A; Forsell MN; Hedestam GBK; Mascola JR; Wyatt RT
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(5):1512-1517

  Soluble factors produced by activated CD4⁺ T cells modulate EBV latency

  Nagy N; Adori M; Rasul A; Heuts F; Salamon D; Ujvari D; Madapura HS; Leveau B; Klein G; Klein E
• Article: BIOLOGICS: TARGETS AND THERAPY. 2012;6:101-115

  Exacerbation of collagen induced arthritis by Fcγ receptor targeted collagen peptide due to enhanced inflammatory chemokine and cytokine production.

  Szarka E; Neer Z; Balogh P; Adori M; Angyal A; Prechl J; Kiss E; Kövesdi D; Sármay G
• Article: IMMUNOLOGY. 2011;134(3):257-269

  Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation

  Gujer C; Sundling C; Seder RA; Hedestam GBK; Lore K
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(18):7499-7504

  Adenovirus type-35 vectors block human CD4⁺ T-cell activation via CD46 ligation

  Adams WC; Gujer C; McInerney G; Gall JGD; Petrovas C; Hedestam GBK; Koup RA; Lore K
• Article: JOURNAL OF VIROLOGY. 2011;85(7):3128-3141

  Potent and Broad Neutralization of HIV-1 Subtype C by Plasma Antibodies Targeting a Quaternary Epitope Including Residues in the V2 Loop

  Moore PL; Gray ES; Sheward D; Madiga M; Ranchobe N; Lai Z; Honnen WJ; Nonyane M; Tumba N; Hermanus T; Sibeko S; Mlisana K; Karim SSA; Williamson C; Pinter A; Morris L
• Article: PLOS ONE. 2011;6(1):e16074

  Heterologous Epitope-Scaffold Prime:Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant

  Guenaga J; Dosenovic P; Ofek G; Baker D; Schief WR; Kwong PD; Hedestam GBK; Wyatt RT
• Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2011;89(6):811-821

  IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naive B cell differentiation

  Gujer C; Sandgren KJ; Douagi I; Adams WC; Sundling C; Smed-Sorensen A; Seder RA; Hedestam GBK; Lore K
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2011;27(10):A40

  Superinfection Results in Potent Neutralizing Antibody Responses to the Superinfecting Virus, but Does Not Necessarily Enhance Neutralization Breadth

  Sheward DJ; Moore PL; Madiga MC; Gray ES; Ntale R; Woodman ZL; Bhiman J; Harvey H; Sibeko S; Mlisana K; Karim SSA; Morris L; Williamson C
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2011;27(10):A29

  Evolution of HIV-1 Transmitted/Founder Viruses Results in the Formation of Epitopes for Later Broadly Cross-Neutralizing Antibodies

  Moore PL; Gray ES; Hermanus T; Sheward D; Tumba N; Wibmer CK; Bhiman J; Sibeko S; Karim SSA; Williamson C; Morris L
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2011;27(10):A15-A16

  Identification of Amino Acid Residues in HIV-1 Envelope Targeted by Plasma Broadly Neutralizing Antibodies using Evolutionary Models

  Lacerda M; Moore PL; Ngandu N; Gray ES; Wibmer K; Nonyane M; Sheward D; Korber BT; Montefiori DC; Williamson C; Morris L; Seoighe C
• Corrigendum: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(10):2283

  Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates (vol 207, pg 2003, 2010)

  Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
• Article: JOURNAL OF VIROLOGY. 2010;84(18):9086-9095

  Immunization with Wild-Type or CD4-Binding-Defective HIV-1 Env Trimers Reduces Viremia Equivalently following Heterologous Challenge with Simian-Human Immunodeficiency Virus

  Sundling C; O'Dell S; Douagi I; Forsell MN; Morner A; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(9):2003-2017

  Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates

  Sundling C; Forsell MNE; O'Dell S; Feng Y; Chakrabarti B; Rao SS; Lore K; Mascola JR; Wyatt RT; Douagi I; Hedestam GBK
• Article: AUTOPHAGY. 2010;6(5):634-641

  A novel quantitative flow cytometry-based assay for autophagy

  Eng KE; Panas MD; Hedestam GBK; McInerney GM
• Published conference paper: IMMUNOLOGY LETTERS. 2010;130(1-2):89-96

  A closer look into the GL7 antigen: its spatio-temporally selective differential expression and localization in lymphoid cells and organs in human.

  Balogh A; Adori M; Török K; Matko J; László G
• Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2010;67(10):1661-1674

  Estrogen augments the T cell-dependent but not the T-independent immune response.

  Adori M; Kiss E; Barad Z; Barabás K; Kiszely E; Schneider A; Kövesdi D; Sziksz E; Abrahám IM; Matkó J; Sármay G
• Journal article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2010;14:e20

  Understanding Anti-HIV Antibody Targets

  Moore P; Gray E; Madiga M; Ranchobe N; Lambson B; Abrahams M-R; Bandawe G; Sheward D; Thebus R; Mlisana K; Karim SA; Williamson C; Morris L
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(7):3046-3051

  A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα

  Siggs OM; Berger M; Krebs P; Arnold CN; Eidenschenk C; Huber C; Pirie E; Smart NG; Khovananth K; Xia Y; McInerney G; Hedestam GBK; Nemazee D; Beutler B
• Article: JOURNAL OF VIROLOGY. 2010;84(4):1683-1695

  Influence of Novel CD4 Binding-Defective HIV-1 Envelope Glycoprotein Immunogens on Neutralizing Antibody and T-Cell Responses in Nonhuman Primates

  Douagi I; Forsell MNE; Sundling C; O'Dell S; Feng Y; Dosenovic P; Li Y; Seder R; Lore K; Mascola JR; Wyatt RT; Hedestam GBK
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2010;26(10):A24-A25

  Mapping of residues critical for neutralisation by a broadly cross-neutralising antibody targeting a quaternary epitope on the HIV-1 Envelope

  Sheward DJ; Moore PL; Thebus R; Gray ES; Madiga M; Ranchobe N; Mlisana K; Karim SSA; Morris L; Williamson C
• Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2010;26(10):A51

  Potent and broad neutralization of HIV-1 subtype C viruses by an antibody targeting a quaternary epitope including residues in the V2 loop

  Moore PL; Gray ES; Sheward D; Madiga M; Ranchobe N; Thebus R; Lai Z; Honnen WJ; Mlisana K; Karim SA; Pinter A; Williamson C; Morris L
• Review: EUROPEAN JOURNAL OF HAEMATOLOGY. 2010;84(1):17-25

  Characterisation of hairy cell leukaemia by tiling resolution array-based comparative Genome hybridisation: a series of 13 cases and review of the literature

  Nordgren A; Corcoran M; Saaf A; Bremer A; Kluin-Nelemans HC; Schoumans J; Grander D
• Article: BREAST CANCER RESEARCH. 2010;12(6):R105

  Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer

  Akhoondi S; Lindstrom L; Widschwendter M; Corcoran M; Bergh J; Spruck C; Grander D; Sangfelt O
• Article: EXPERIMENTAL CELL RESEARCH. 2009;315(17):2941-2952

  DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

  Lerner M; Harada M; Loven J; Castro J; Davis Z; Oscier D; Henriksson M; Sangfelt O; Grander D; Corcoran MM
• Meeting abstract: RETROVIROLOGY. 2009;6:p178

  Analysis of antibody and B cell responses following inoculation with computationally designed HIV-1 2F5 epitope scaffold proteins

  Dosenovic P; Guenaga J; Ofek G; Baker D; Schief W; Kwong PD; Hedestam GBK; Wyatt RT
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(37):15756-15761

  The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

  Vilborg A; Glahder JA; Wilhelm MT; Bersani C; Corcoran M; Mahmoudi S; Rosenstierne M; Grander D; Farnebo M; Norrild B; Wiman KG
• Article: JOURNAL OF IMMUNOLOGY. 2009;183(5):3373-3382

  Selective Expansion of HIV-1 Envelope Glycoprotein-Specific B Cell Subsets Recognizing Distinct Structural Elements Following Immunization

  Dosenovic P; Chakrabarti B; Soldemo M; Douagi I; Forsell MNE; Li Y; Phogat A; Paulie S; Hoxie J; Wyatt RT; Hedestam GBK
• Article: CURRENT OPINION IN HIV AND AIDS. 2009;4(5):441-446

  Novel adjuvants for B cell immune responses

  Lore K; Hedestam GBK
• Article: CELL DEATH AND DIFFERENTIATION. 2009;16(7):1018-1029

  Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

  Laane E; Tamm KP; Buentke E; Ito K; Kharaziha P; Oscarsson J; Corcoran M; Bjorklund A-C; Hultenby K; Lundin J; Heyman M; Soderhall S; Mazur J; Porwit A; Pandolfi PP; Zhivotovsky B; Panaretakis T; Grander D
• Article: JOURNAL OF GENERAL VIROLOGY. 2009;90(Pt 7):1600-1610

  Adenovirus serotype 5 infects human dendritic cells via a coxsackievirus-adenovirus receptor-independent receptor pathway mediated by lactoferrin and DC-SIGN

  Adams WC; Bond E; Havenga MJE; Holterman L; Goudsmit J; Hedestam GBK; Koup RA; Lore K
• Article: MOLECULAR CELL. 2009;33(4):462-471

  Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

  Mahmoudi S; Henriksson S; Corcoran M; Mendez-Vidal C; Wiman KG; Farnebo M
• Article: JOURNAL OF IMMUNOLOGY. 2009;182(4):1991-2001

  Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells

  Douagi I; Gujer C; Sundling C; Adams WC; Smed-Soerensen A; Seder RA; Hedestam GBK; Lore K
• Article: JOURNAL OF VIROLOGY. 2009;83(2):540-551

  Human Immunodeficiency Virus Type 1 Env Trimer Immunization of Macaques and Impact of Priming with Viral Vector or Stabilized Core Protein

  Moerner A; Douagi I; Forsell MNE; Sundling C; Dosenovic P; O'Dell S; Dey B; Kwong PD; Voss G; Thorstensson R; Mascola JR; Wyatt RT; Hedestam GBK
• Review: JOURNAL OF INNATE IMMUNITY. 2009;1(6):599-606

  Direct Cleavage, Proteasomal Degradation and Sequestration: Three Mechanisms of Viral Subversion of Type I Interferon Responses

  McInerney GM; Hedestam GBK
• Article: JOURNAL OF GENERAL VIROLOGY. 2008;89(Pt 12):2954-2964

  CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization

  Sundling C; Schon K; Morner A; Forsell MNE; Wyatt RT; Thorstensson R; Hedestam GBK; Lycke NY
• Article: PLOS PATHOGENS. 2008;4(10):e1000171

  B Cell Recognition of the Conserved HIV-1 Co-Receptor Binding Site Is Altered by Endogenous Primate CD4

  Forsell MNE; Dey B; Moerner A; Svehla K; O'dell S; Hoegerkorp C-M; Voss G; Thorstensson R; Shaw GM; Mascola JR; Hedestam GBK; Wyatt RT
• Article: LEUKEMIA & LYMPHOMA. 2008;49(3):477-487

  Characterization of 6q deletions in mature B cell lymphomas and childhood acute lymphoblastic leukemia

  Thelander EF; Ichimura K; Corcoran M; Barbany G; Nordgren A; Heyman M; Berglund M; Mungall A; Rosenquist R; Collins VP; Grander D; Larsson C; Lagercrantz S
• Review: NATURE REVIEWS MICROBIOLOGY. 2008;6(2):143-155

  The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.

  Karlsson Hedestam GB; Fouchier RAM; Phogat S; Burton DR; Sodroski J; Wyatt RT
• Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):238

  Human B cell responses to toll-like receptor ligands are differentially modulated by myloid and plasmacytoid dendritic cells

  Douagi I; Gujer C; Sundling C; Adams WC; Smed-Soerensen A; Seder RA; Karlsson-Hedestam G; Lore K
• Article: HAEMATOLOGICA. 2007;92(11):1460-1469

  Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members

  Laane E; Panaretakis T; Pokrovskaja K; Buentke E; Corcoran M; Soderhall S; Heyman M; Mazur J; Zhivotovsky B; Porwit A; Grander D
• Article: CANCER RESEARCH. 2007;67(19):9006-9012

  FBXW7/hCDC4 is a general tumor suppressor in human cancer

  Akhoondi S; Sun D; von der Lehr N; Apostolidou S; Klotz K; Maljukova A; Cepeda D; Fiegl H; Dofou D; Marth C; Mueller-Holzner E; Corcoran M; Dagnell M; Nejad SZ; Nayer BN; Zali MR; Hansson J; Egyhazi S; Petersson F; Sangfelt P; Nordgren H; Grander D; Reed SI; Widschwendter M; Sangfelt O; Spruck C
• Article: JOURNAL OF GENERAL VIROLOGY. 2007;88(Pt 10):2774-2779

  Increased human immunodeficiency virus type 1 Env expression and antibody induction using an enhanced alphavirus vector

  Forsell MNE; McInerney GM; Dosenovic P; Hidmark AS; Eriksson C; Liljestorm P; Grundner C; Hedestam GBK
• Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;372(1):150-159

  Crystal structure of conserved domains 1 and 2 of the human DEAD-box helicase DDX3X in complex with the mononucleotide AMP

  Hogbom M; Collins R; van den Berg S; Jenvert R-M; Karlberg T; Kotenyova T; Flores A; Hedestam GBK; Schiavone LH
• Article: JOURNAL OF VIROLOGY. 2007;81(16):8677-8684

  Semliki forest virus nonstructural protein 2 is involved in suppression of the type I interferon response

  Breakwell L; Dosenovic P; Hedestam GBK; D'Amato M; Liljestrom P; Fazakerley J; McInerney GM
• Published conference paper: JOURNAL OF INTERNAL MEDICINE. 2007;262(1):26-43

  Inhibition of HIV-1 entry by antibodies: potential viral and cellular targets.

  Phogat S; Wyatt RT; Karlsson Hedestam GB
• Article: CANCER RESEARCH. 2007;67(12):5611-5616

  The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling

  Malyukova A; Dohda T; von der Lehr N; Akhondi S; Corcoran M; Heyman M; Spruck C; Grander D; Lendahl U; Sangfelt O
• Letter: LEUKEMIA. 2007;21(6):1327-1330

  Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification:: the result of telomere dysfunction and breakage/fusion/breakage cycles?

  Kuchinskaya E; Nordgren A; Heyman M; Schoumans J; Corcoran M; Staaf J; Borg A; Soderhall S; Grander D; Nordenskjold M; Blennow E
• Article: MOLECULAR BIOLOGY OF THE CELL. 2007;18(5):1670-1682

  The RBCC gene RFP2 (leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD

  Lerner M; Corcoran M; Cepeda D; Nielsen ML; Zubarev R; Ponten F; Uhlen M; Hober S; Grander D; Sangfelt O
• Article: JOURNAL OF VIROLOGY. 2007;81(6):2758-2768

  Role of interferon regulatory factor 3 in type I interferon responses in rotavirus-infected dendritic cells and fibroblasts

  Douagi I; McInerney GA; Hidmark AS; Miriallis V; Johansen K; Svensson L; Hedestam GBK
• Article: EXPERIMENTAL CELL RESEARCH. 2007;313(2):404-414

  Phosphoinositide 3-kinase regulates a subset of interferon-alpha-stimulated genes

  Hjortsberg L; Lindvall C; Corcoran M; Arulampalam V; Chan D; Thyrell L; Nordenskjold M; Grander D; Pokrovskaja K
• Review: HUMAN GENE THERAPY. 2006;17(11):1051-1061

  DNA vaccines: Recent developments and future possibilities

  Liu MA; Wahren B; Hedestam GBK
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 2006;135(4):492-499

  Characterisation of dic(9;20)(p11-13;q11) in childhood B-cell precursor acute lymphoblastic leukaemia by tiling resolution array-based comparative genomic hybridisation reveals clustered breakpoints at 9p13.2 and 20q11.2

  Schoumans J; Johansson B; Corcoran M; Kuchinskaya E; Golovleva I; Grander D; Forestier E; Staaf J; Borg A; Gustafsson B; Blennow E; Nordgren A
• Corrigendum: JOURNAL OF IMMUNOLOGY. 2006;177(8):5748

  DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection (vol 177, pg 2908, 2006)

  Sjolin H; Robbins SH; Bessou G; Hidmark A; Tomasello E; Johansson M; Hall H; Charifi F; Hedestam GBK; Biron CA; Karre K; Hoglund P; Vivier E; Dalod M
• Article: JOURNAL OF IMMUNOLOGY. 2006;177(5):2908-2916

  DAP12 signalling regulates plasmacytoid ddendritic cell homeostasis and down-modulates their function during viral infection

  Sjolin H; Robbins SH; Bessou G; Hidmark A; Tomasello E; Johansson M; Hall H; Charifi F; Hedestam GBK; Biron CA; Karre K; Hoglund P; Vivier E; Dalod M
• Article: JOURNAL OF VIROLOGY. 2006;80(14):7100-7110

  Humoral responses against coimmunized protein antigen but not against alphavirus-encoded antigens require alpha/beta interferon signaling

  Hidmark AS; Nordstrom EKL; Dosenovic P; Forsell MNE; Liljestrom P; Hedestam GBK
• Article: EXPERIMENTAL CELL RESEARCH. 2006;312(11):1989-1995

  LUMA (LUminometric Methylation Assay) -: A high throughput method to the analysis of genomic DNA methylation

  Karimi M; Johansson S; Stach D; Corcoran M; Grander D; Schalling M; Bakalkin G; Lyko F; Larsson C; Ekstrom TJ
• Article: VIROLOGY. 2005;341(2):190-202

  Efficient expansion of HIV-1-specific T cell responses by homologous immunization with recombinant Semliki Forest virus particles

  Sundbäck M; Douagi I; Dayaraj C; Forsell MNE; Nordström EKL; McInerney GM; Spångberg K; Tjäder L; Bonin E; Sundström M; Liljeström P; Hedestam GBK
• Article: JOURNAL OF VIROLOGY. 2005;79(17):10902-10914

  Biochemical and immunogenic characterization of soluble human immunodeficiency virus type 1 envelope glycoprotein trimers expressed by Semliki Forest virus

  Forsell MNE; Li YX; Sundbäck M; Svehla K; Liljeström P; Mascola JR; Wyatt R; Hedestam GBK
• Article: JOURNAL OF VIROLOGY. 2005;79(16):10376-10385

  Early alpha/beta interferon production by myeloid dendritic cells in response to UV-inactivated virus requires viral entry and interferon regulatory factor 3 but not MyD88

  Hidmark Å; McInerney GM; Nordström EKL; Douagi I; Werner KM; Liljeström P; Hedestam GBK
• Article: HAEMATOLOGICA. 2005;90(8):1078-1088

  ZAP-70 methylation status is associated with ZAP-70 expression status in chronic lymphocytic leukemia

  Corcoran M; Parker A; Orchard J; Davis Z; Wirtz M; Schmitz OJ; Oscier D
• Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2005;74(6):466-480

  Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles

  Kuchinskaya E; Heyman M; Grandér D; Linderholm M; Söderhäll S; Zaritskey A; Nordgren A; Porwit-MacDonald A; Zueva E; Pawitan Y; Corcoran M; Nordenskjöld M; Blennow E
• Article: JOURNAL OF GENERAL VIROLOGY. 2005;86(Pt 2):349-354

  Enhanced immunogenicity using an alphavirus replicon DNA vaccine against human immunodeficiency virus type 1

  Nordström EKL; Forsell MNE; Barnfield C; Bonin E; Hanke T; Sundström M; Karlsson GB; Liljeström P
• Article: HUMAN MOLECULAR GENETICS. 2004;13(23):2925-2936

  Disruption of a novel ectodermal neural cortex 1 antisense gene, ENC-1AS and identification of ENC-1 overexpression in hairy cell leukemia

  Hammarsund M; Lerner M; Zhu CY; Merup M; Jansson M; Gahrton G; Kluin-Nelemans H; Einhorn S; Grandér D; Sangfelt O; Corcoran M
• Article: BRITISH JOURNAL OF CANCER. 2004;91(8):1488-1494

  Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level

  Karlsson GB; Jensen A; Stevenson LF; Woods YL; Lane DP; Sorensen MS
• Article: GENES CHROMOSOMES & CANCER. 2004;40(4):285-297

  DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse

  Corcoran MM; Hammarsund M; Zhu CY; Lerner M; Kapanadze B; Wilson B; Larsson C; Forsberg L; Ibbotson RE; Stefan E; Oscier DG; Grandér D; Sangfelt O
• Article: GENES CHROMOSOMES & CANCER. 2004;40(1):78-83

  Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome

  Grand EK; Grand FH; Chase AJ; Ross FM; Corcoran MM; Oscier DG; Cross NCP
• Article: FEBS LETTERS. 2004;556(1-3):75-80

  Characterization of a novel B-CLL candidate gene -: DLEU7 -: located in the 13q14 tumor suppressor locus

  Hammarsund M; Corcoran MM; Wilson W; Zhu CY; Einhorn S; Sangfelt O; Grander D
• Article: METHODS IN MOLECULAR BIOLOGY. 2004;246:543-557

  Delivery and expression of heterologous genes in mammalian cells using self-replicating alphavirus vectors.

  Karlsson GB; Liljeström P
• Article: GENE. 2003;321:103-112

  Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse:: multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS

  Baranova A; Hammarsund M; Ivanova DV; Skoblov M; Sangfelt O; Corcoran M; Borodina T; Makeeva N; Pestova A; Tyazhelova T; Nazarenko S; Gorreta F; Alsheddi T; Schlauch K; Nikitin E; Kapanadze B; Shagin D; Poltaraus A; Vorobiev AI; Zabarovsky E; Lukianov S; Chandhoke V; Ibbotson R; Oscier D; Einhorn S; Grander D; Yankovsky N
• Letter: BLOOD. 2003;102(8):3075

  To the editor: Divergence from the germ-line sequence in unmutated chronic lymphocytic leukemia is due to somatic mutation rather than polymorphisms

  Davis ZA; Orchard JA; Corcoran MM; Oscier DG
• Article: GENOMICS. 2003;82(3):343-354

  Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter-binding protein: new DENN domain-containing protein family emerges

  Semova N; Kapanadze B; Corcoran M; Kutsenko A; Baranova A; Semov A
• Article: METHODS IN MOLECULAR MEDICINE. 2003;87:69-82

  Live viral vectors: Semliki Forest virus.

  Karlsson GB; Liljeström P
• Article: BLOOD. 2002;100(4):1177-1184

  Multivariate analysis of prognostic factors in CLL:: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors

  Oscier DG; Gardiner AC; Mould SJ; Glide S; Davis ZA; Ibbotson RE; Corcoran MM; Chapman RM; Thomas PW; Copplestone JA; Orchard JA; Hamblin TJ
• Article: HUMAN GENETICS. 2001;109(5):542-550

  Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution

  Hammarsund M; Wilson W; Corcoran M; Merup M; Einhorn S; Grandér D; Sangfelt O
• Article: GENES CHROMOSOMES & CANCER. 2001;32(2):155-163

  Identification of four new translocations involving FGFRI in myeloid disorders

  Sohal J; Chase A; Mould S; Corcoran M; Oscier D; Iqbal S; Parker S; Welborn J; Harris RI; Martinelli G; Montefusco V; Sinclair P; Wilkins BS; van den Berg H; Vanstraelen D; Goldman JM; Cross NCP
• Article: GENOMICS. 2000;70(3):327-334

  Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14

  Kapanadze B; Makeeva N; Corcoran M; Jareborg N; Hammarsund M; Baranova A; Zabarovsky E; Vorontsova O; Merup M; Gahrton G; Jansson M; Yankovsky N; Einhorn S; Oscier D; Grandér D; Sangfelt O
• Article: ONCOGENE. 1999;18(46):6271-6277

  Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

  Corcoran MM; Mould SJ; Orchard JA; Ibbotson RE; Chapman RM; Boright AP; Platt C; Tsui LC; Scherer SW; Oscier DG
• Article: JOURNAL OF VIROLOGY. 1999;73(10):8873-8879

  Determinants of neutralization resistance in the envelope glycoproteins of a simian-human immunodeficiency virus passaged in vivo.

  Etemad-Moghadam B; Sun Y; Nicholson EK; Karlsson GB; Schenten D; Sodroski J
• Article: JOURNAL OF VIROLOGY. 1999;73(7):5373-5380

  Effects of soluble CD4 on simian immunodeficiency virus infection of CD4-positive and CD4-negative cells.

  Schenten D; Marcon L; Karlsson GB; Parolin C; Kodama T; Gerard N; Sodroski J
• Article: VIROLOGY. 1999;256(1):15-21

  Viral burden and disease progression in rhesus monkeys infected with chimeric simian-human immunodeficiency viruses.

  Reimann KA; Watson A; Dailey PJ; Lin W; Lord CI; Steenbeke TD; Parker RA; Axthelm MK; Karlsson GB
• Article: JOURNAL OF VIROLOGY. 1999;73(2):976-984

  Changes in human immunodeficiency virus type 1 envelope glycoproteins responsible for the pathogenicity of a multiply passaged simian-human immunodeficiency virus (SHIV-HXBc2).

  Cayabyab M; Karlsson GB; Etemad-Moghadam BA; Hofmann W; Steenbeke T; Halloran M; Fanton JW; Axthelm MK; Letvin NL; Sodroski JG
• Article: JOURNAL OF VIROLOGY. 1998;72(10):8437-8445

  Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys.

  Etemad-Moghadam B; Karlsson GB; Halloran M; Sun Y; Schenten D; Fernandes M; Letvin NL; Sodroski J
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1998;188(6):1159-1171

  The envelope glycoprotein ectodomains determine the efficiency of CD4+ T lymphocyte depletion in simian-human immunodeficiency virus-infected macaques.

  Karlsson GB; Halloran M; Schenten D; Lee J; Racz P; Tenner-Racz K; Manola J; Gelman R; Etemad-Moghadam B; Desjardins E; Wyatt R; Gerard NP; Marcon L; Margolin D; Fanton J; Axthelm MK; Letvin NL; Sodroski J
• Article: LEUKEMIA. 1998;12(5):705-709

  A FISH cosmid 'cocktail' for detection of 13q deletions in chronic lymphocytic leukaemia - comparison with cytogenetics and Southern hybridization

  Merup M; Jansson M; Corcoran M; Liu Y; Wu X; Rasool OZ; Stellan B; Hermansson M; Juliusson G; Gahrton G; Einhorn S
• Article: FEBS LETTERS. 1998;426(2):266-270

  A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5

  Kapanadze B; Kashuba V; Baranova A; Rasool O; van Everdink W; Liu Y; Syomov A; Corcoran M; Poltaraus A; Brodyansky V; Syomova N; Kazakov A; Ibbotson R; van den Berg A; Gizatullin R; Fedorova L; Sulimova G; Zelenin A; Deaven L; Lehrach H; Grander D; Buys C; Oscier D; Zabarovsky ER; Einhorn S; Yankovsky N
• Article: BLOOD. 1998;91(4):1382-1390

  Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia

  Corcoran MM; Rasool O; Liu Y; Iyengar A; Grander D; Ibbotson RE; Merup M; Wu XS; Brodyansky V; Gardiner AC; Juliusson G; Chapman RM; Ivanova G; Tiller M; Gahrton G; Yankovsky N; Zabarovsky E; Oscier DG; Einhorn S
• Article: ONCOGENE. 1997;15(20):2463-2473

  Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia

  Liu Y; Corcoran M; Rasool O; Ivanova G; Ibbotson R; Grander D; Iyengar A; Baranova A; Kashuba V; Merup M; Wu XS; Gardiner A; Mullenbach R; Poltaraus A; Hultstrom AL; Juliusson G; Chapman R; Tiller M; Cotter F; Gahrton G; Yankovsky N; Zabarovsky E; Einhorn S; Oscier D
• Article: JOURNAL OF VIROLOGY. 1997;71(11):8582-8591

  Immunoglobulin V(H) usage during primary infection of rhesus monkeys with chimeric simian-human immunodeficiency viruses.

  Margolin DH; Reimann KA; Sodroski J; Karlsson GB; Tenner-Racz K; Racz P; Letvin NL
• Article: GENES CHROMOSOMES & CANCER. 1997;20(1):73-81

  Cytogenetic, fluorescence in situ hybridisation, and clinical evaluation of translocations with concomitant deletion at 13q14 in chronic lymphocytic leukaemia

  Gardiner AC; Corcoran MM; Oscier DG
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1997;186(3):405-411

  Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.

  Farzan M; Choe H; Martin K; Marcon L; Hofmann W; Karlsson G; Sun Y; Barrett P; Marchand N; Sullivan N; Gerard N; Gerard C; Sodroski J
• Article: JOURNAL OF VIROLOGY. 1997;71(6):4218-4225

  Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.

  Karlsson GB; Halloran M; Li J; Park IW; Gomila R; Reimann KA; Axthelm MK; Iliff SA; Letvin NL; Sodroski J
• Article: LEUKEMIA. 1996;10(11):1712-1714

  PCR analysis of polymorphisms at the D13S25 locus

  Ibbotson RE; Chapman RM; Corcoran MM; Oscier DG
• Article: JOURNAL OF VIROLOGY. 1996;70(10):7153-7160

  N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with impaired gp120 shedding and gp41 exposure.

  Fischer PB; Karlsson GB; Dwek RA; Platt FM
• Article: JOURNAL OF VIROLOGY. 1996;70(10):7143-7152

  N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120.

  Fischer PB; Karlsson GB; Butters TD; Dwek RA; Platt FM
• Article: JOURNAL OF VIROLOGY. 1996;70(10):6922-6928

  A chimeric simian/human immunodeficiency virus expressing a primary patient human immunodeficiency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys.

  Reimann KA; Li JT; Veazey R; Halloran M; Park IW; Karlsson GB; Sodroski J; Letvin NL
• Article: JOURNAL OF VIROLOGY. 1996;70(9):6136-6142

  Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses.

  Karlsson GB; Gao F; Robinson J; Hahn B; Sodroski J
• Review: JOURNAL OF VIROLOGY. 1996;70(3):1651-1667

  Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization.

  Gao F; Morrison SG; Robertson DL; Thornton CL; Craig S; Karlsson G; Sodroski J; Morgado M; Galvao-Castro B; von Briesen H; Beddows S; Weber J; Sharp PM; Shaw GM; Hahn BH
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 1996;92(2):389-392

  Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia

  Mould S; Gardiner A; Corcoran M; Oscier DG
• Other: JOURNAL OF VIROLOGY. 1995;69(9):5791-5797

  The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding.

  Fischer PB; Collin M; Karlsson GB; James W; Butters TD; Davis SJ; Gordon S; Dwek RA; Platt FM
• Preprint: BIORXIV.

  Neutralisation sensitivity of the SARS-CoV-2 BA.2.87.1 variant

  Sheward DJ; Marking U; Bladh O; Held S; Looyens E; Vandenabeele L; Muschiol S; Aguilera K; Norin NG; Öling S; Westerberg M; Martin D; Hedestam GBK; Albert J; Thålin C; Murrell B
• Visa fler

Finansiering

Forskningsbidrag

• Genetic basis for antibody diversity

  Swedish Research Council

Medarbetare och kontakt

Gruppledare

• 

  Gunilla Karlsson Hedestam

  Professor

  Telefon +46852486955

  E-postadress gunilla.karlsson.hedestam@ki.se

Alla medarbetare i gruppen

• 

  Xaquin Castro Dopico

  Forskningsspecialist

  E-postadress xaquin.castro.dopico@ki.se
• 

  Mariia Chernigovskaia

  Postdoktor

  E-postadress mariia.chernigovskaia@ki.se
• 

  Martin Corcoran

  Enhetschef

  E-postadress martin.corcoran@ki.se
• Tilak Das

  Forskningsassistent

  E-postadress tilak.das@ki.se
• 

  Alexandra Fischer

  Doktorand

  E-postadress alexandra.fischer@ki.se
• Mariia Guryleva

  Doktorand

  E-postadress mariia.guryleva@ki.se
• 

  Mateusz Kaduk

  Bioinformatiker

  E-postadress mateusz.kaduk@ki.se
• 

  Gunilla Karlsson Hedestam

  Professor

  Telefon +46852486955

  E-postadress gunilla.karlsson.hedestam@ki.se
• 

  Rafael Marques

  Doktorand

  E-postadress rafael.marques@ki.se
• 

  Sanjana Narang

  Postdoktor

  E-postadress sanjana.narang@ki.se
• 

  Pradeepa Pushparaj

  Postdoktor

  E-postadress pradeepa.pushparaj@ki.se
• 

  Isabel Regadas

  Forskningsspecialist

  E-postadress isabel.regadas@ki.se
• 

  Fabian Alexander Schleich

  Doktorand

  E-postadress fabian.schleich@ki.se
• 

  Daniel Sheward

  Biträdande Lektor

  E-postadress daniel.sheward@ki.se
• Ioannis Zygouras

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  E-postadress ioannis.zygouras@ki.se
• 

  Monika Ádori

  Senior Forskningsspecialist

  E-postadress monika.adori@ki.se