Silvia Maiolis forskargrupp

Publikationer

Alla gruppmedlemmars publikationer

Journal article: BMC MEDICINE. 2025;23(1):82
Antidepressant use and cognitive decline in patients with dementia: a national cohort study
Mo M; Abzhandadze T; Hoang MT; Sacuiu S; Jurado PG; Pereira JB; Naia L; Kele J; Maioli S; Xu H; Eriksdotter M; Garcia-Ptacek S
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2025;:glaf031
Association of plasma fatty acid profile with trajectory of multimorbidity and mortality: A community-based longitudinal study.
Li Y; Wang J; Miao Y; Dunk MM; Maioli S; Fang Z; Zhang Q; Xu W
Preprint: BIORXIV. 2025;BIORXIV
Cell-type specific profiling of human entorhinal cortex at the onset of Alzheimer's disease neuropathology.
Rodriguez-Rodriguez P; Wang W; Tsagkogianni C; Feng I; Morello-Megias A; Jain K; Alanko V; Kahvecioglu H-A; Mohammadi E; Li X; Flajolet M; Sandebring-Matton A; Maioli S; Vidal N; Milosevic A; Roussarie J-P
Article: JOURNAL OF ALZHEIMERS DISEASE. 2025;103(3):931-940
Medications and cognitive decline in Alzheimer's disease: Cohort cluster analysis of 15,428 patients.
Grau-Jurado P; Mostafaei S; Xu H; Mo M; Petek B; Kalar I; Naia L; Kele J; Maioli S; Pereira JB; Eriksdotter M; Chatterjee S; Garcia-Ptacek S
Preprint: BIORXIV. 2024;BIORXIV
Astrocyte-derived extracellular matrix proteins regulate synapse remodeling in stress-induced depression.
Zhang R; Rodriguez-Rodriguez P; Medrihan L; Chang JC; Ferraro T; Del Cioppo Vasques P; Wang W; Menard C; Cathomas F; Chan KL; Parise L; Shaham S; Roussarie J-P; Troyanskaya O; Russo SJ; Milosevic A
Preprint: BIORXIV. 2024;BIORXIV
ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer's disease.
Demetriou A; Lindqvist B; Ali HG; Shamekh MM; Maioli S; Inzunza J; Varshney M; Nilsson P; Nalvarte I
Article: BRAIN. 2024;147(7):2384-2399
A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons
Rodriguez-Rodriguez P; Arroyo-Garcia LE; Tsagkogianni C; Li L; Wang W; Vegvari A; Salas-Allende I; Plautz Z; Cedazo-Minguez A; Sinha SC; Troyanskaya O; Flajolet M; Yao V; Roussarie J-P
Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;119:286-300
Dynamic microglia alterations associate with hippocampal network impairments: A turning point in amyloid pathology progression
Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
Preprint: BIORXIV. 2024
Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression
Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez PR; Cabrera GV; Laterza S; Leal ML; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-García LE
Review: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2024;166:111218
Author instructions in biomedical journals infrequently address systematic review reporting and methodology: a cross-sectional study
Rehlicki D; Plenkovic M; Delac L; Pieper D; Marusic A; Puljak L
Article: SCIENCE ADVANCES. 2024;10(4):eadj1354
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice
Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-Garcia LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Bjoerkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1347535
Impaired astrocytic synaptic function by peripheral cholesterol metabolite 27-hydroxycholesterol
Spanos F; Gerenu G; Goikolea J; Latorre-Leal M; Balleza-Tapia H; Gomez K; Alvarez-Jimenez L; Piras A; Gomez-Galan M; Fisahn A; Cedazo-Minguez A; Maioli S; Loera-Valencia R
Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):220
Statins and cognitive decline in patients with Alzheimer's and mixed dementia: a longitudinal registry-based cohort study
Petek B; Habel H; Xu H; Villa-Lopez M; Kalar I; Hoang MT; Maioli S; Pereira JB; Mostafaei S; Winblad B; Gregoric Kramberger M; Eriksdotter M; Garcia-Ptacek S
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387
Different effects of CYP27A1 and CYP7B1 on cognitive function: Two mouse models in comparison
Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Bjorkhem I; Rodriguez PR; Maioli S
Article: JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 2023;18(3):529-550
SIRT2 Inhibition Rescues Neurodegenerative Pathology but Increases Systemic Inflammation in a Transgenic Mouse Model of Alzheimer's Disease
Sola-Sevilla N; Mesa-Lombardo A; Aleixo M; Exposito S; Diaz-Perdigon T; Azqueta A; Zamani F; Suzuki T; Maioli S; Eroli F; Matton A; Ramirez MJ; Solas M; Tordera RM; Martin ED; Puerta E
Article: BRAIN COMMUNICATIONS. 2023;5(5):fcad228
Alzheimer's disease biomarker profiling in a memory clinic cohort without common comorbidities
Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths WJ; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Matton A
Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):141
A metagenomic study of gut viral markers in amyloid-positive Alzheimer's disease patients
Ghorbani M; Ferreira D; Maioli S
Article: GLIA. 2023;71(6):1414-1428
27-hydroxycholesterol promotes oligodendrocyte maturation: Implications for hypercholesterolemia-associated brain white matter changes
Alanko V; Gaminde-Blasco A; Quintela-Lopez T; Loera-Valencia R; Solomon A; Bjorkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Sandebring-Matton A
Conference publication: GLIA. 2023;71:E633
Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia
Goicolea J; Roussarie JP; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
Preprint: BIORXIV. 2022
Identifying genes and pathways linking astrocyte regional specificity to Alzheimer’s disease susceptibility
Zhang R; Knudsen M; Vasques PDC; Tadych A; Rodriguez-Rodriguez P; Greengard P; Roussarie J-P; Milosevic A; Troyanskaya O
Article: BIOMEDICINE & PHARMACOTHERAPY. 2022;155:113708
Evaluation of the therapeutic efficacy of dressings with ZnO nanoparticles in the treatment of diabetic foot ulcers
Loera-Valencia R; Neira RE; Urbina BP; Camacho A; Galindo RB
Preprint: BIORXIV. 2022
Alzheimer’s disease biomarker profiling in a memory clinic cohort without common comorbidities
Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths W; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Sandebring-Matton A
Preprint: BIORXIV. 2022
The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer’s disease vulnerable neurons
Rodriguez-Rodriguez P; Arroyo-Garcia LE; Li L; Tsagkogianni C; Wang W; Salas-Allende I; Plautz Z; Cedazo-Minguez A; Sinha S; Troyanskaya O; Flajolet M; Yao V; Roussarie J-P
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245
Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App^{NL-G-F/NL-G-F} mice
Emre C; Arroyo-Garcia LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
Preprint: BIORXIV. 2022
Neuron-derived Thioredoxin-80: a novel regulator of type-I interferon response in microglia
Goikolea J; Roussarie J-P; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
Review: PROGRESS IN NEUROBIOLOGY. 2022;210:102213
Functionally-distinct pyramidal cell subpopulations during gamma oscillations in mouse hippocampal area CA3
Balleza-Tapia H; Arroyo-Garcia LE; Isla AG; Loera-Valencia R; Fisahn A
Article: ALZHEIMERS RESEARCH & THERAPY. 2022;14(1):37
Serum Thioredoxin-80 is associated with age, ApoE4, and neuropathological biomarkers in Alzheimer's disease: a potential early sign of AD
Goikolea J; Gerenu G; Daniilidou M; Mangialasche F; Mecocci P; Ngandu T; Rinne J; Solomon A; Kivipelto M; Cedazo-Minguez A; Sandebring-Matton A; Maioli S
Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:836196
Defects of Nutrient Signaling and Autophagy in Neurodegeneration
Ondaro J; Hernandez-Eguiazu H; Garciandia-Arcelus M; Loera-Valencia R; Rodriguez-Gomez L; Jimenez-Zuniga A; Goikolea J; Rodriguez-Rodriguez P; Ruiz-Martinez J; Moreno F; Lopez de Munain A; Holt IJ; Gil-Bea FJ; Gerenu G
Conference publication: 2022;:219-227
Integrated Label Transfer for Oligodendrocyte Subpopulation Profiling in Parkinson’s Disease and Multiple System Atrophy
Teeple E; Joshi P; Pande R; Huang Y; Karambe A; Latta-Mahieu M; Sardi S; Cedazo-Minguez A; Klinger K; Flores-Morales A; Madden S; Rajpal D; Kumar D
Review: ESSAYS IN BIOCHEMISTRY. 2021;65(6):913-925
Estrogen receptors and the aging brain
Maioli S; Leander K; Nilsson P; Nalvarte I
Article: MOLECULAR NEUROBIOLOGY. 2021;58(12):6063-6076
Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration
Loera-Valencia R; Ismail M-A; Goikolea J; Lodeiro M; Mateos L; Bjorkhem I; Puerta E; Romao MA; Gomes CM; Merino-Serrais P; Maioli S; Cedazo-Minguez A
Doctoral thesis: 2021
Translational studies on Alzheimer’s disease : a focus on cholesterol metabolism, thioredoxin-80 and microglia function
Goicolea J
Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567
Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the App^NL-G-F mouse model of Alzheimer's disease
Arroyo-Garcia LE; Isla AG; Andrade-Talavera Y; Balleza-Tapia H; Loera-Valencia R; Alvarez-Jimenez L; Pizzirusso G; Tambaro S; Nilsson P; Fisahn A
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(18):10139
Brain Renin-Angiotensin System as Novel and Potential Therapeutic Target for Alzheimer's Disease
Loera-Valencia R; Eroli F; Garcia-Ptacek S; Maioli S
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3194-3204
Sex difference in flux of 27-hydroxycholesterol into the brain
Parrado-Fernandez C; Leoni V; Saeed A; Rodriguez-Rodriguez P; Sandebring-Matton A; Cordoba-Beldad CM; Bueno P; Gali CC; Panzenboeck U; Cedazo-Minguez A; Bjorkhem I
Article: AGING-US. 2021;13(11):14729-14744
Long-term exposure to polypharmacy impairs cognitive functions in young adult female mice
Eroli F; Johnell K; Latorre-Leal M; Hilmer S; Wastesson J; Cedazo-Minguez A; Maioli S
Preprint: BIORXIV. 2021
Single Nuclei Sequencing of Human Putamen Oligodendrocytes Reveals Altered Heterogeneity and Disease-Associated Changes in Parkinson’s Disease and Multiple System Atrophy
Teeple E; Joshi P; Pande R; Huang Y; Karambe A; Latta-Mahieu M; Sardi SP; Cedazo-Minguez A; Klinger KW; Flores-Morales A; Madden SL; Rajpal D; Kumar D
Preprint: BIORXIV. 2021
Single Cell Atlas of Human Putamen Reveals Disease Specific Changes in Synucleinopathies: Parkinson’s Disease and Multiple System Atrophy
Pande R; Huang Y; Teeple E; Joshi P; Flores-Morales A; Latta-Mahieu M; Sardi SP; Cedazo-Minguez A; Klinger KW; Madden SL; Rajpal D; Kumar D
Preprint: RESEARCH SQUARE. 2021
27-Hydroxycholesterol Promotes Oligodendrocyte Maturation – Implications for Hypercholesterolemia Associated Brain White Matter Changes
Alanko V; Quintela-López T; Gaminde-Blasco A; Loera-Valencia R; Solomon A; Björkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Matton A
Preprint: BIORXIV. 2021
Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging
Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Daniilidou M; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths W; Björkhem I; Sandebring Matton A; Merino-Serrais P; Cedazo-Minguez A; Maioli S
Article: MOLECULAR PSYCHIATRY. 2021;26(4):1410-1423
Thioredoxin-80 protects against amyloid-beta pathology through autophagic-lysosomal pathway regulation
Gerenu G; Persson T; Goikolea J; Calvo-Garrido J; Loera-Valencia R; Pottmeier P; Santiago C; Poska H; Presto J; Cedazo-Minguez A
Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):56
27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial
Sandebring-Matton A; Goikolea J; Bjorkhem I; Paternain L; Kemppainen N; Laatikainen T; Ngandu T; Rinne J; Soininen H; Cedazo-Minguez A; Solomon A; Kivipelto M
Article: SCIENTIFIC REPORTS. 2021;11(1):3736
High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus
Loera-Valencia R; Vazquez-Juarez E; Munoz A; Gerenu G; Gomez-Galan M; Lindskog M; DeFelipe J; Cedazo-Minguez A; Merino-Serrais P
Review: ADVANCES IN PHARMACOLOGY. 2021;90:145-171
Deciphering cell-type specific signal transduction in the brain: Challenges and promises.
Roussarie J-P; Rodriguez-Rodriguez P
Journal article: MOLECULAR PSYCHIATRY. 2021;26(1):1-2
Irradiation-induced changes in neural progenitor cells are reversed by lithium: Immature newborn dentate granule neurons display dendritic processes that are either tangential or parallel to the granule cell layer of the dentate gyrus of the hippocampus
Zanni G; Goto S; Fragopoulou AF; Gaudenzi G; Naidoo V; Di Martino E; Levy G; Dominguez CA; Dethlefsen O; Cedazo-Minguez A; Merino-Serrais P; Stamatakis A; Hermanson O; Blomgren K
Article: MOLECULAR PSYCHIATRY. 2021;26(1):322-340
Lithium treatment reverses irradiation-induced changes in rodent neural progenitors and rescues cognition
Zanni G; Goto S; Fragopoulou AF; Gaudenzi G; Naidoo V; Di Martino E; Levy G; Dominguez CA; Dethlefsen O; Cedazo-Minguez A; Merino-Serrais P; Stamatakis A; Hermanson O; Blomgren K
Article: NEUROSCIENCE. 2020;448:14-27
Chronic Airway Allergy Induces Pro-Inflammatory Responses in the Brain of Wildtype Mice but Not 3xTgAD Mice
Sarlus H; Codita A; Wang X; Cedazo-Minguez A; Schultzberg M; Oprica M
Article: NEURON. 2020;107(5):821-835.e12
Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis
Roussarie J-P; Yao V; Rodriguez-Rodriguez P; Oughtred R; Rust J; Plautz Z; Kasturia S; Albornoz C; Wang W; Schmidt EF; Dannenfelser R; Tadych A; Brichta L; Barnea-Cramer A; Heintz N; Hof PR; Heiman M; Dolinski K; Flajolet M; Troyanskaya OG; Greengard P
Article: AGING-US. 2020;12(11):10147-10161
Chronic polypharmacy impairs explorative behavior and reduces synaptic functions in young adult mice
Eroli F; Johnell K; Leal ML; Adamo C; Hilmer S; Wastesson JW; Cedazo-Minguez A; Maioli S
Article: NEUROBIOLOGY OF DISEASE. 2020;134:104645
Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration
Hoglund K; Schussler N; Kvartsberg H; Smailovic U; Brinkmalm G; Liman V; Becker B; Zetterberg H; Cedazo-Minguez A; Janelidze S; Lefevre IA; Eyquem S; Hansson O; Blennow K
Article: FRONTIERS IN GENETICS. 2020;11:1022
Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL
Panahi M; Rodriguez PR; Fereshtehnejad S-M; Arafa D; Bogdanovic N; Winblad B; Cedazo-Minguez A; Rinne J; Darreh-Shori T; Hase Y; Kalaria RN; Viitanen M; Behbahani H
Review: JOURNAL OF INTERNAL MEDICINE. 2019;286(4):398-437
Current and emerging avenues for Alzheimer's disease drug targets
Loera-Valencia R; Cedazo-Minguez A; Kenigsberg PA; Page G; Duarte AI; Giusti P; Zusso M; Robert P; Frisoni GB; Cattaneo A; Zille M; Boltze J; Cartier N; Buee L; Johansson G; Winblad B
Article: CELL DEATH AND DIFFERENTIATION. 2019;26(9):1545-1565
Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation
Guerrero-Gomez D; Antonio Mora-Lorca J; Saenz-Narciso B; Jose Naranjo-Galindo F; Munoz-Lobato F; Parrado-Fernandez C; Goikolea J; Cedazo-Minguez A; Link CD; Neri C; Dolores Sequedo M; Vazquez-Manrique RP; Fernandez-Suarez E; Goder V; Pane R; Cabiscol E; Askjaer P; Cabello J; Miranda-Vizuete A
Corrigendum: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(6):4489
Corrigendum.
Review: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;190:104-114
Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment
Loera-Valencia R; Goikolea J; Parrado-Fernandez C; Merino-Serraisa P; Maioli S
Article: NEUROCHEMISTRY INTERNATIONAL. 2019;126:74-85
Long-term application of cannabinoids leads to dissociation between changes in cAMP and modulation of GABA_A receptors of mouse trigeminal sensory neurons
Celotto L; Eroli F; Nistri A; Vilotti S
Preprint: BIORXIV. 2019
Lithium treatment reverses irradiation-induced changes in rodent neural progenitors
Giulia Z; Shinobu G; Giulia G; Vinogran N; Gabriel L; Elena DM; Olga D; Angel C-M; Paula M-S; Ola H; Klas B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(11):4169-4176
24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo
Theofilopoulos S; de Oliveira WAA; Yang S; Yutuc E; Saeed A; Abdel-Khalik J; Ullgren A; Cedazo-Minguez A; Bjorkhem I; Wang Y; Griffiths WJ; Arenas E
Article: SCIENTIFIC REPORTS. 2019;9(1):3965
Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases
Caberlotto L; Nguyen T-P; Lauria M; Priami C; Rimondini R; Maioli S; Cedazo-Minguez A; Sita G; Morroni F; Corsi M; Carboni L
Review: ADVANCES IN AGGREGATION INDUCED EMISSION MATERIALS IN BIOSENSING AND IMAGING FOR BIOMEDICAL APPLICATIONS, PT A. 2019;168:257-275
Restoring synaptic function through multimodal therapeutics
Loera-Valencia R; Ismail M-A; Nilsson P; Winblad B
Article: CEREBRAL CORTEX. 2019;29(1):429-446
27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons
Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Bjorkhem I; DeFelipe J; Cedazo-Minguez A
Review: JOURNAL OF INTERNAL MEDICINE. 2018;284(6):620-642
Connecting the brain cholesterol and renin-angiotensin systems: potential role of statins and RAS-modifying medications in dementia
Petek B; Villa-Lopez M; Loera-Valencia R; Gerenu G; Winblad B; Kramberger MG; Ismail M-A; Eriksdotter M; Garcia-Ptacek S
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(11):5439-5449
Reduction of PINK1 or DJ-1 impair mitochondrial motility in neurites and alter ER-mitochondria contacts
Parrado-Fernandez C; Schneider B; Ankarcrona M; Conti MM; Cookson MR; Kivipelto M; Cedazo-Minguez A; Sandebring-Matton A
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(10):5151-5154
Evidence for sex difference in the CSF/plasma albumin ratio in ∼20 000 patients and 335 healthy volunteers
Parrado-Fernandez C; Blennow K; Hansson M; Leoni V; Cedazo-Minguez A; Bjorkhem I
Article: PHARMACOLOGICAL REPORTS. 2018;70(4):677-683
Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes
Kazkayasi I; Burul-Bozkurt N; Ismail M-A; Merino-Serrais P; Pekiner C; Cedazo-Minguez A; Uma S
Review: JOURNAL OF INTERNAL MEDICINE. 2018;284(1):2-36
Targeting Alzheimer's disease with gene and cell therapies
Loera-Valencia R; Piras A; Ismail MAM; Manchanda S; Eyjolfsdottir H; Saido TC; Johansson J; Eriksdotter M; Winblad B; Nilsson P
Preprint: BIORXIV. 2018
Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation
Guerrero-Gómez D; Mora-Lorca JA; Sáenz-Narciso B; Naranjo-Galindo FJ; Muñoz-Lobato F; Parrado-Fernández C; Cedazo-Minguez Á; Link C; Neri C; Sequedo MD; Vázquez-Manrique R; Fernández-Suárez E; Goder V; Pané R; Cabiscol E; Askjaer P; Cabello J; Miranda-Vizuete A
Corrigendum: BRAIN. 2018;141(5):e43
Corrigendum.
Article: PLOS ONE. 2018;13(3):e0194892
The composition of polypharmacy: A register-based study of Swedes aged 75 years and older
Wastesson JW; Minguez AC; Fastbom J; Maioli S; Johnell K
Article: BRAIN. 2017;140(12):3269-3285
Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons
Rodriguez-Rodriguez P; Sandebring-Matton A; Merino-Serrais P; Parrado-Fernandez C; Rabano A; Winblad B; Avila J; Ferrer I; Cedazo-Minguez A
Review: ALZHEIMER'S AND DEMENTIA: TRANSLATIONAL RESEARCH AND CLINICAL INTERVENTIONS. 2017;3(4):571-578
Toward common mechanisms for risk factors in Alzheimer's syndrome.
Medina M; Khachaturian ZS; Rossor M; Avila J; Cedazo-Minguez A
Journal article: INNOVATION IN AGING. 2017;1(suppl_1):1040
ARE ANIMAL MODELS VALUABLE FOR AGING RESEARCH? LESSONS FROM ALZHEIMER’S DISEASE
Cedazo-Minguez A
Review: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):534-553
Can LDL cholesterol be too low? Possible risks of extremely low levels
Olsson AG; Angelin B; Assmann G; Binder CJ; Bjoerkhem I; Cedazo-Minguez A; Cohen J; von Eckardstein A; Farinaro E; Mueller-Wieland D; Parhofer KG; Parini P; Rosenson RS; Starup-Linde J; Tikkanen MJ; Yvan-Charvet L
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(3):699-717
27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation
Ismail M-A; Mateos L; Maioli S; Merino-Serrais P; Ali Z; Lodeiro M; Westman E; Leitersdorf E; Gulyas B; Olof-Wahlund L; Winblad B; Savitcheva I; Bjorkhem I; Cedazo-Minguez A
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(3):319-328
Aggregation of the Inflammatory S100A8 Precedes Aβ Plaque Formation in Transgenic APP Mice: Positive Feedback for S100A8 and Aβ Productions
Lodeiro M; Puerta E; Ismail M-A; Rodriguez-Rodriguez P; Ronnback A; Codita A; Parrado-Fernandez C; Maioli S; Gil-Bea F; Merino-Serrais P; Cedazo-Minguez A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2017;56(2):601-617
Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis
Persson T; Lattanzio F; Calvo-Garrido J; Rimondini R; Rubio-Rodrigo M; Sundstrom E; Maioli S; Sandebring-Matton A; Cedazo-Minguez A
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1862(11):2110-2118
Anthocyanins protect from complex I inhibition and APPswe mutation through modulation of the mitochondrial fission/fusion pathways
Parrado-Fernandez C; Sandebring-Matton A; Rodriguez-Rodriguez P; Aarsland D; Cedazo-Minguez A
Article: ALZHEIMERS & DEMENTIA. 2016;12(11):1149-1158
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia
Bereczki E; Francis PT; Howlett D; Pereira JB; Hoglund K; Bogstedt A; Cedazo-Minguez A; Baek J-H; Hortobagyi T; Attems J; Ballard C; Aarsland D
Article: NEUROSCIENCE LETTERS. 2016;633:174-181
Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats
Kazkayasi I; Ismail M-A; Parrado-Fernandez C; Bjorkhem I; Pekiner C; Uma S; Cedazo-Minguez A; Burul-Bozkurt N
Article: SCIENTIFIC REPORTS. 2016;6:30928
Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk
Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CMP; Bjorkhem I; Ruas JL; Rodrigues E
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(1):349-361
Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease
Tajeddinn W; Persson T; Calvo-Garrido J; Ahmed MS; Maioli S; Vijayaraghavan S; Kazokoglu MS; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Hoglund K; Cedazo-Minguez A; Aarsland D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(2):621-630
Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers
Tajeddinn W; Fereshtehnejad S-M; Ahmed MS; Yoshitake T; Kehr J; Shahnaz T; Milovanovic M; Behbahani H; Hoglund K; Winblad B; Cedazo-Minguez A; Jelic V; Jaremo P; Aarsland D
Article: LANCET NEUROLOGY. 2016;15(5):455-532
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad B; Amouyel P; Andrieu S; Ballard C; Brayne C; Brodaty H; Cedazo-Minguez A; Dubois B; Edvardsson D; Feldman H; Fratiglioni L; Frisoni GB; Gauthier S; Georges J; Graff C; Iqbal K; Jessen F; Johansson G; Jonsson L; Kivipelto M; Knapp M; Mangialasche F; Melis R; Nordberg A; Rikkert MO; Qiu C; Sakmar TP; Scheltens P; Schneider LS; Sperling R; Tjernberg LO; Waldemar G; Wimo A; Zetterberg H
Article: JOURNAL OF ALZHEIMERS DISEASE. 2015;47(2):523-529
Autoantibodies Toward the Angiotensin 2 Type 1 Receptor: A Novel Autoantibody in Alzheimer's Disease
Giil LM; Kristoffersen EK; Vedeler CA; Aarsland D; Nordrehaug JE; Winblad B; Cedazo-Minguez A; Lund A; Reksten TR
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2015;70(6):675-685
Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse
Orejana L; Barros-Minones L; Jordan J; Cedazo-Minguez A; Tordera RM; Aguirre N; Puerta E
Article: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 2015;41(4):471-482
Decreased levels of guanosine 3, 5-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease
Ugarte A; Gil-Bea F; Garcia-Barroso C; Cedazo-Minguez A; Ramirez MJ; Franco R; Garcia-Osta A; Oyarzabal J; Cuadrado-Tejedor M
Article: NEUROSCIENCE LETTERS. 2015;594:137-143
5-HT1B and other related serotonergic proteins are altered in APPswe mutation
Tajeddinn W; Persson T; Maioli S; Calvo-Garrido J; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Hoglund K; Cedazo-Minguez A; Aarsland D
Article: JOURNAL OF VIROLOGY. 2015;89(8):4645-4654
Triatoma virus recombinant VP4 protein induces membrane permeability through dynamic pores.
Sánchez-Eugenia R; Goikolea J; Gil-Cartón D; Sánchez-Magraner L; Guérin DMA
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2015;55(2):396-405
Insufficient Resolution Response in the Hippocampus of a Senescence-Accelerated Mouse Model-SAMP8
Wang X; Puerta E; Cedazo-Minguez A; Hjorth E; Schultzberg M
Article: BEHAVIOURAL BRAIN RESEARCH. 2015;278:356-359
27-Hydroxycholesterol mediates negative effects of dietary cholesterol on cognition in mice
Heverin M; Maioli S; Pham T; Mateos L; Camporesi E; Ali Z; Winblad B; Cedazo-Minguez A; Bjorkhem I
Article: AGING CELL. 2015;14(1):122-129
Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease
Maioli S; Lodeiro M; Merino-Serrais P; Falahati F; Khan W; Puerta E; Codita A; Rimondini R; Ramirez MJ; Simmons A; Gil-Bea F; Westman E; Cedazo-Minguez A
Article: MOLECULAR NEUROBIOLOGY. 2015;51(3):1489-1503
Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells
Moutinho M; Nunes MJ; Gomes AQ; Gama MJ; Cedazo-Minguez A; Rodrigues CMP; Bjorkhem I; Rodrigues E
Article: INTERNATIONAL JOURNAL OF SPORTS MEDICINE. 2015;36(1):54-60
Resistance Training Does not have an Effect on Cognition or Related Serum Biomarkers in Nonagenarians: A Randomized Controlled Trial
Ruiz JR; Gil-Bea F; Bustamante-Ara N; Rodriguez-Romo G; Fiuza-Luces C; Serra-Rexach JA; Cedazo-Minguez A; Lucia A
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2014;69(9):1132-1138
Vitamin D in Relation to Cognitive Impairment, Cerebrospinal Fluid Biomarkers, and Brain Volumes
Hooshmand B; Lokk J; Solomon A; Mangialasche F; Miralbell J; Spulber G; Annerbo S; Andreasen N; Winblad B; Cedazo-Minguez A; Wahlund L-O; Kivipelto M
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2014;466(9):1805-1818
Cholinergic signalling-regulated K_V7.5 currents are expressed in colonic ICC-IM but not ICC-MP
Wright GWJ; Parsons SP; Loera-Valencia R; Wang X-Y; Barajas-Lopez C; Huizinga JD
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_13):p516
P2‐123: BIOMARKERS FOR COGNITIVE DECLINE OF EARLY PARKINSON's DISEASE
Bereczki E; Hoglund K; Svenningsson P; Cedazo‐Minguez A; Francis P; Ballard CG; Aarsland D
Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2014;34(5):727-736
Expression of P2X₃ and P2X₅ Myenteric Receptors Varies During the Intestinal Postnatal Development in the Guinea Pig
Loera-Valencia R; Jimenez-Vargas NN; Villalobos EC; Juarez EH; Liliana Lomas-Ramos T; Espinosa-Luna R; Montano LM; Huizinga JD; Barajas-Lopez C
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_17):p639-p640
P3‐033: 5HT1B‐RECEPTOR AND RELATED SEROTONERGIC CHANGES IN ALZHEIMER'S DISEASE MODELS
Abderhim WT; Höglund K; Cedazo‐Minguez A; Aarsland D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;41(1):223-232
Decreased Cerebrospinal Fluid Levels of L-Carnitine in Non-Apolipoprotein E4 Carriers at Early Stages of Alzheimer's Disease
Lodeiro M; Ibanez C; Cifuentes A; Simo C; Cedazo-Minguez A
Article: JOURNAL OF INTERNAL MEDICINE. 2014;275(3):296-303
Pathways to Alzheimer's disease
Hardy J; Bogdanovic N; Winblad B; Portelius E; Andreasen N; Cedazo-Minguez A; Zetterberg H
Review: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2014;2014:427318-11
Oxidative Stress in Alzheimer's Disease: Why Did Antioxidant Therapy Fail?
Persson T; Popescu BO; Cedazo-Minguez A
Article: CELLULAR & MOLECULAR BIOLOGY LETTERS. 2014;19(4):601-610
Ano1 is a better marker than c-Kit for transcript analysis of single interstitial cells of Cajal in culture
Loera-Valencia R; Wang X-Y; Wright GWJ; Barajas-Lopez C; Huizinga JD
Review: FRONTIERS IN PHARMACOLOGY. 2014;5:146
Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?
Franco R; Cedazo-Minguez A
Article: FEBS OPEN BIO. 2014;4:393-406
Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations
Wanngren J; Lara P; Ojemalm K; Maioli S; Moradi N; Chen L; Tjernberg LO; Lundkvist J; Nilsson I; Karlstrom H
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2013;33(12):1843-1845
Underestimation of the pentose-phosphate pathway in intact primary neurons as revealed by metabolic flux analysis
Rodriguez-Rodriguez P; Fernandez E; Bolanos JP
Article: JOURNAL OF ALZHEIMERS DISEASE. 2013;37(4):713-733
Intracellular Localization of Amyloid-β Peptide in SH-SY5Y Neuroblastoma Cells
Zheng L; Calvo-Garrido J; Hallbeck M; Hultenby K; Marcusson J; Cedazo-Minguez A; Terman A
Article: JOURNAL OF CHROMATOGRAPHY A. 2013;1302:65-71
A new metabolomic workflow for early detection of Alzheimer's disease
Ibanez C; Simo C; Barupal DK; Fiehn O; Kivipelto M; Cedazo-Minguez A; Cifuentes A
Article: JOURNAL OF NEUROINFLAMMATION. 2013;10:99
Chronic airway-induced allergy in mice modifies gene expression in the brain toward insulin resistance and inflammatory responses
Sarlus H; Wang X; Cedazo-Minguez A; Schultzberg M; Oprica M
Review: NEUROCHEMISTRY INTERNATIONAL. 2013;62(5):750-756
Brain energy metabolism in glutamate-receptor activation and excitotoxicity: Role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway
Rodriguez-Rodriguez P; Almeida A; Bolanos JP
Article: PLOS ONE. 2013;8(7):e68534
Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?
Maioli S; Bavner A; Ali Z; Heverin M; Ismail M-A; Puerta E; Olin M; Saeed A; Shafaati M; Parini P; Cedazo-Minguez A; Bjorkhem I
Article: ANALYTICAL CHEMISTRY. 2012;84(20):8532-8540
Toward a Predictive Model of Alzheimer's Disease Progression Using Capillary Electrophoresis-Mass Spectrometry Metabolomics
Ibanez C; Simo C; Martin-Alvarez PJ; Kivipelto M; Winblad B; Cedazo-Minguez A; Cifuentes A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;32(2):341-355
Combination of Apolipoprotein E4 and High Carbohydrate Diet Reduces Hippocampal BDNF and Arc Levels and Impairs Memory in Young Mice
Maioli S; Puerta E; Merino-Serrais P; Fusari L; Gil-Bea F; Rimondini R; Cedazo-Minguez A
Article: EMBO MOLECULAR MEDICINE. 2012;4(10):1097-1111
Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain
Gil-Bea F; Akterin S; Persson T; Mateos L; Sandebring A; Avila-Carino J; Gutierrez-Rodriguez A; Sundstrom E; Holmgren A; Winblad B; Cedazo-Minguez A
Article: CELL DEATH AND DIFFERENTIATION. 2012;19(10):1582-1589
Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
Rodriguez-Rodriguez P; Fernandez E; Almeida A; Bolanos JP
Article: TRANSLATIONAL NEURODEGENERATION. 2012;1(1):19
Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system
Zheng L; Cedazo-Minguez A; Hallbeck M; Jerhammar F; Marcusson J; Terman A
Article: BEHAVIOURAL BRAIN RESEARCH. 2012;230(2):349-354
Excitotoxic lesion of the perirhinal cortex impairs spatial working memory in a delayed-alternation task
Maioli S; Gangarossa G; Locchi F; Andrioli A; Bertini G; Rimondini R
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;29(4):741-749
Grey Matter and Cognitive Patterns in Cognitive Impaired Subjects Using CSF Biomarker Cut-Offs
Miralbell J; Spulber G; Hooshmand B; Besga A; Mataro M; Cedazo-Minguez A; Kivipelto M; Wahlund L-O
Corrigendum: NEUROSCIENCE LETTERS. 2012;514(2):219
Estrogen protects against amyloid-β toxicity by estrogen receptor α-mediated inhibition of Daxx translocation (vol 506, pg 245, 2011)
Mateos L; Persson T; Katoozi S; Gil-Bea FJ; Cedazo-Minguez A
Article: NEUROSCIENCE LETTERS. 2012;510(2):121-126
Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
Besga A; Cedazo-Minguez A; Kareholt I; Solomon A; Bjorkhem I; Winblad B; Leoni V; Hooshmand B; Spulber G; Gonzalez-Pinto A; Kivipelto M; Wahlund LO
Article: NEUROSCIENCE LETTERS. 2012;506(2):245-250
Estrogen protects against amyloid-β toxicity by estrogen receptor α-mediated inhibition of Daxx translocation
Mateos L; Persson T; Kathozi S; Gil-Bea FJ; Cedazo-Minguez A
Published conference paper: NEURODEGENERATIVE DISEASES. 2012;10(1-4):313-316
Side-Chain-Oxidized Oxysterols Upregulate ACE2 and Mas Receptor in Rat Primary Neurons
Mateos L; Ismail M-A; Winblad B; Cedazo-Minguez A
Article: AUTOPHAGY. 2011;7(12):1528-1545
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells
Zheng L; Terman A; Hallbeck M; Dehvari N; Cowburn RF; Benedikz E; Kagedal K; Cedazo-Minguez A; Marcusson J
Article: ELECTROPHORESIS. 2011;32(19):2757-2764
Analysis of chiral amino acids in cerebrospinal fluid samples linked to different stages of Alzheimer disease
Samakashvili S; Ibanez C; Simo C; Gil-Bea FJ; Winblad B; Cedazo-Minguez A; Cifuentes A
Article: HIPPOCAMPUS. 2011;21(9):999-1009
Cholinergic Hypofunction Impairs Memory Acquisition Possibly Through Hippocampal Arc and BDNF Downregulation
Gil-Bea FJ; Solas M; Mateos L; Winblad B; Ramirez MJ; Cedazo-Minguez A
Corrigendum: JOURNAL OF ALZHEIMERS DISEASE. 2011;25(4):763
Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease (vol 24, pg 669, 2011)
Mateos L; Ismail M-A; Gil-Bea F-J; Leoni V; Winblad B; Bjoerkhem I; Cedazo-Minguez A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(29):25574-25585
Side Chain-oxidized Oxysterols Regulate the Brain Renin-Angiotensin System through a Liver X Receptor-dependent Mechanism
Mateos L; Ismail M-A; Gil-Bea F-J; Schuele R; Schoels L; Heverin M; Folkesson R; Bjorkhem I; Cedazo-Minguez A
Article: JOURNAL OF ALZHEIMERS DISEASE. 2011;24(4):669-679
Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease
Mateos L; Ismail M-A; Gil-Bea F-J; Leoni V; Winblad B; Bjorkhem I; Cedazo-Minguez A
Review: EXPERT REVIEW OF NEUROTHERAPEUTICS. 2011;11(4):495-498
Plasma cholesterol and risk for late-onset Alzheimer's disease
Cedazo-Minguez A; Ismail M-A; Mateos L
Article: HUMAN MOLECULAR GENETICS. 2011;20(1):40-50
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
Thomas KJ; McCoy MK; Blackinton J; Beilina A; van der Brug M; Sandebring A; Miller D; Maric D; Cedazo-Minguez A; Cookson MR
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;22(3):829-838
HPA Axis Dysregulation Associated to Apolipoprotein E4 Genotype in Alzheimer's Disease
Gil-Bea FJ; Aisa B; Solomon A; Solas M; del Carmen Mugueta M; Winblad B; Kivipelto M; Cedazo-Minguez A; Ramirez MJ
Article: JOURNAL OF ALZHEIMERS DISEASE. 2010;22(2):405-413
Insulin Levels are Decreased in the Cerebrospinal Fluid of Women with Prodomal Alzheimer's Disease
Gil-Bea FJ; Solas M; Solomon A; Mugueta C; Winblad B; Kivipelto M; Ramirez MJ; Cedazo-Minguez A
Journal article: ALZHEIMERS & DEMENTIA. 2010;6(4S_Part_20):e32
P4‐042: The Role of Oxidative Stress and Autophagy in Amyloid Beta‐protein Toxicity to Cultured Neuroblastoma Cells
Zheng L; Dehvari N; Benedikz E; Cowburn R; Terman A; Cedazo-Minguez A; Marcusson J
Article: ONCOGENE. 2010;29(10):1531-1542
Ezrin mediates c-Myc actions in prostate cancer cell invasion
Chuan Y-C; Iglesias-Gato D; Fernandez-Perez L; Cedazo-Minguez A; Pang S-T; Norstedt G; Pousette A; Flores-Morales A
Review: EXPERIMENTAL GERONTOLOGY. 2010;45(1):5-14
Biomarkers for Alzheimer's disease and other forms of dementia: Clinical needs, limitations and future aspects
Cedazo-Minguez A; Winblad B
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2010;17:662
Neurotrophic factors and Alzheimer's disease: role and therapeutic possibilities
Cedazo-Minguez A
Article: FOOD MICROBIOLOGY. 2009;26(8):841-846
Multilocus sequence typing of oenological Saccharomyces cerevisiae strains
Munoz R; Gomez A; Robles V; Rodriguez P; Cebollero E; Tabera L; Carrascosa AV; Gonzalez R
Article: FEBS JOURNAL. 2009;276(18):5041-5052
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling
Sandebring A; Dehvari N; Perez-Manso M; Thomas KJ; Karpilovski E; Cookson MR; Cowburn RF; Cedazo-Minguez A
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(9B):3061-3068
Parkin-mediated ubiquitination regulates phospholipase C-γ1
Dehvari N; Sandebring A; Flores-Morales A; Mateos L; Chuan Y-C; Goldberg MS; Cookson MR; Cowburn RF; Cedazo-Minguez A
Article: BIOPHYSICAL JOURNAL. 2009;97(1):277-285
Influence of Residue 22 on the Folding, Aggregation Profile, and Toxicity of the Alzheimer's Amyloid β Peptide
Peralvarez-Marin A; Mateos L; Zhang C; Singh S; Cedazo-Minguez A; Visa N; Morozova-Roche L; Graslund A; Barth A
Review: MOLECULAR ASPECTS OF MEDICINE. 2009;30(3):171-179
Oxysterols and neurodegenerative diseases
Bjorkhem I; Cedazo-Minguez A; Leoni V; Meaney S
Article: PLOS ONE. 2009;4(5):e5701
Mitochondrial Alterations in PINK1 Deficient Cells Are Influenced by Calcineurin-Dependent Dephosphorylation of Dynamin-Related Protein 1
Sandebring A; Thomas KJ; Beilina A; van der Brug M; Cleland MM; Ahmad R; Miller DW; Zambrano I; Cowburn RF; Behbahani H; Cedazo-Minguez A; Cookson MR
Article: JOURNAL OF NEUROIMMUNOLOGY. 2009;208(1-2):46-53
Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain
Spulber S; Mateos L; Oprica M; Cedazo-Minguez A; Bartfai T; Winblad B; Schultzberg M
Article: BRAIN PATHOLOGY. 2009;19(1):69-80
Activity-Regulated Cytoskeleton-Associated Protein in Rodent Brain is Down-Regulated by High Fat Diet in vivo and by 27-Hydroxycholesterol in vitro
Mateos L; Akterin S; Gil-Bea F-J; Spulber S; Rahman A; Bjorkhem I; Schultzberg M; Flores-Morales A; Cedazo-Minguez A
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2008;12(6B):2762-2771
Apolipoprotein E ε4 magnifies lifestyle risks for dementia: a population-based study
Kivipelto M; Rovio S; Ngandu T; Kareholt I; Eskelinen M; Winblad B; Hachinski V; Cedazo-Minguez A; Soininen H; Tuomilehto J; Nissinen A
Article: PHARMACOLOGICAL RESEARCH. 2008;58(1):32-37
Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain
Sallam H; Jimenez P; Song H; Vita M; Cedazo-Minguez A; Hassan M
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_20):t643
P3‐414: Activity‐regulated cytoskeleton‐associated protein in rodent brain is down‐regulated by high fat diet in vivo and by 27‐hydroxycholesterol in vitro
Mateos L; Akterin S; Gil-Bea F-J; Spulber S; Rahman A; Björkhem I; Schultzberg M; Flores-Morales A; Cedazo-Minguez A
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_23):t752
P4‐276: Characterization of Thioredoxin‐80 in the brain and its relevance in Alzheimer′s disease
Gil-Bea FJ; Akterin S; Mateos-Montejo L; Avila-Carino J; Holmgren A; Winblad B; Cedazo-Minguez A
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_20):t639-t640
P3‐403: Parkin ubiquitylates phospholipase C–γ1 and protects against dopamine induced cell death
Dehvari N; Sandebring A; Flores-Morales A; Mateos L; Karpilovski E; Cookson MR; Goldberg MS; Cowburn RF; Cedazo-Minguez A
Meeting abstract: BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2008;1777:S55
Altered mitochondrial dynamics caused by loss of PTEN-induced kinase 1 function, associated with recessive parkinsonism, are reversed by downregulation of Dynamin-related protein 1
Thomas KJ; Sandebring A; Beilina A; van der Brug M; Cleland MM; Zambrano I; Miller DW; Unger C; Cowburn R; Youle R; Behbahani H; Cedazo-Minguez A; Cookson MR
Article: PEDIATRIC TRANSPLANTATION. 2008;12(4):412-419
Prospective analysis of carotid arterial wall structure in pediatric renal transplants with ambulatory normotension and in treated hypertensive recipients
Krmar RT; Balzano R; Jogestrand T; Cedazo-Minguez A; Englund MS; Berg UB
Article: NEUROSCIENCE LETTERS. 2008;436(1):77-80
Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism
Dehvari N; Isacsson O; Winblad B; Cedazo-Minguez A; Cowburn RF
Conference publication: HAEMATOLOGICA. 2008;93:497
AGE DEPENDANT PHARMACOKINETICS OF ROSCOVITINE ANT ITS EFFECT ON BRAIN CDK5 AND ERK 1/2 IN RAT PUPS
Sallam H; Jimenez P; Vita M; Cedazo-Minguez A; Moustapha H
Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2007;11(6):1227-1238
Apolipoprotein E and Alzheimer's disease:: molecular mechanisms and therapeutic opportunities
Cedazo-Minguez A
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):93-97
Presenilin-mediated signal transduction
Cowburn RF; Popescu BO; Ankarcrona M; Dehvari N; Cedazo-Minguez A
Article: JOURNAL OF NEUROCHEMISTRY. 2007;102(3):848-857
Presenilin dependence of phospholipase C and protein kinase C signaling
Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Karlstrom H; Benedikz E; Cowburn RF
Journal article: ALZHEIMERS & DEMENTIA. 2007;3(3S_Part_3):s166-s167
O1–01–03: Healthy lifestyle reduces the risk of dementia especially among the apolipoprotein E e4 carriers
Rovio S; Ngandu T; Kåreholt I; Laitinen M; Winblad B; Haschinski V; Soininen H; Tuomilehto J; Cedazo-Minguez A; Nissinen A; Kivipelto M
Conference publication: PEDIATRIC TRANSPLANTATION. 2007;11:108
Prospective analysis of carotid intima-media thickness (IMT) in normotensive paediatric renal transplants and in recipients with newly diagnosed ambulatory hypertension.
Krmar RT; Balzano R; Jogestrand T; Cedazo-Minguez A; Englund M; Berg UB
Conference publication: FEBS JOURNAL. 2007;274:167
Role of presenilins in signal transduction pathways and cell death in Alzheimer's disease
Popescu BO; Ankarcrona M; Cedazo-Minguez A; Hansson CA; Popescu LM; Cowburn RF; Winblad B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(40):29938-29948
Androgen induction of prostate cancer cell invasion is mediated by ezrin
Chuan Y-C; Pang S-T; Cedazo-Minguez A; Norstedt G; Pousette A; Flores-Morales A
Article: CELL DEATH AND DIFFERENTIATION. 2006;13(9):1454-1465
Involvement of glutaredoxin-1 and thioredoxin-1 in β-amyloid toxicity and Alzheimer's disease
Akterin S; Cowburn RF; Miranda-Vizuete A; Jimenez A; Bogdanovic N; Winblad B; Cedazo-Minguez A
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_16):s495-s496
P3–407: Presenilin dependence of phospholipase C and associated signalling
Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Benedikz E; Cowburn RF
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_2):s47-s48
S3–02–04: Exploring the mechanisms behind risk factors for Alzheimer's disease
Cedazo-Minguez A
Article: JOURNAL OF NEUROCHEMISTRY. 2006;97(2):356-364
Caspase cleaved presenilin-1 is part of active γ-secretase complexes
Hansson CA; Popescu BO; Laudon H; Cedazo-Minguez A; Popescu LM; Winblad B; Ankarcrona M
Article: FEBS LETTERS. 2005;579(28):6411-6416
High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice
Rahman A; Akterin S; Flores-Morales A; Crisby M; Kivipelto M; Schultzberg M; Cedazo-Mínguez A
Conference publication: INTERNATIONAL PSYCHOGERIATRICS. 2005;17:204-205
Presenilin dependence of phospholipase C regulation
Dehvari N; Cedazo-Minguez A; Winblad B; Cowburn R
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S350
Apolipoprotein E and presenilin regulation of cellular signalling
Cowburn R; Cedazo-Minguez A
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S525
The proteasome regulates presenilin 1 levels during apoptosis
Ankarcrona M; Cedazo-Minguez A; Winblad B; Popescu BO
Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:S541-S542
Beta-amyloid oxidation of thioredoxin and glutaredoxin.: A possible link between oxidative stress and apoptosis in Alzheimer's disease
Akterin S; Miranda-Vizuete A; Winblad B; Cowburn RF; Cedazo-Mínguez A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(8):6455-6464
γ-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction
Popescu BO; Cedazo-Minguez A; Benedikz E; Nishimura T; Winblad B; Ankarcrona M; Cowburn RF
Article: JOURNAL OF NEUROCHEMISTRY. 2003;87(5):1152-1164
Apolipoprotein E and β-amyloid (1-42) regulation of glycogen synthase kinase-3β
Cedazo-Mínguez A; Popescu BO; Blanco-Millán JM; Akterin S; Pei JJ; Winblad B; Cowburn RF
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(39):36646-36655
The presenilin 1 ΔE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations
Cedazo-Mínguez A; Popescu BO; Ankarcrona M; Nishimura T; Cowburn RF
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S401-S402
Apolipoprotein E and beta amyloid peptide regulation of glycogen synthase kinase-3 beta
Cedazo-Minguez A; Wiehager B; Pei JJ; Cowburn RF
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S215
The presenilin-1 δE9 mutation gives enhanced phospholipase C activity and a resultant increase in intracellular calcium concentrations
Popescu BO; Cedazo-Minguez A; Ankarcrona M; Nishimura T; Cowburn RF
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2002;12:S56
Mutated presenilin 1 alters cholinergic signaling in neuroblastoma cells
Popescu BO; Cedazo-Mínguez A; Ankarcrona M; Cowburn RF
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2001;66(1):122-134
Caspase cleavage of exon 9 deleted presenilin-1 is an early event in apoptosis induced by calcium ionophore A 23187 in SH-SY5Y neuroblastoma cells
Popescu BO; Cedazo-Minguez A; Popescu LM; Winblad B; Cowburn RF; Ankarcrona M
Article: FEBS LETTERS. 2001;504(1-2):45-49
Apolipoprotein E isoform-specific disruption of phosphoinositide hydrolysis:: protection by estrogen and glutathione
Cedazo-Mínguez A; Cowburn RF
Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2001;5(3):254-266
Apolipoprotein E:: a major piece in the Alzheimer's disease puzzle
Cedazo-Mínguez A; Cowburn RF
Article: NEUROCHEMISTRY INTERNATIONAL. 2001;38(7):615-625
Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) and apoE/Aβ complexes on protein kinase C-α (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
Cedazo-Mínguez A; Wiehager B; Winblad B; Hüttinger M; Cowburn RF
Article: NEUROREPORT. 2001;12(2):201-206
β-VLDL protects against Aβ(I-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells
Cedazo-Mínguez A; Hüttinger M; Cowburn RF
Published conference paper: BIOCHEMICAL SOCIETY SYMPOSIUM. 2001;67(67):121-129
Apolipoprotein E and βA4-amyloid:: signals and effects
Ohm TG; Hamker U; Cedazo-Minguez A; Röckl W; Scharnagl H; März W; Cowburn R; Müller W; Meske V
Article: NEUROSCIENCE. 2001;105(3):651-661
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures
Cedazo-Mínguez A; Hamker U; Meske V; Veh RW; Hellweg R; Jacobi C; Albert F; Cowburn RF; Ohm TG
Journal article: NEUROBIOLOGY OF AGING. 2000;21:252
Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures
Cedazo-Minguez A; Hamker U; Veh R; Meske V; Albert F; Cowburn RF; Ohm TG
Article: NEUROCHEMISTRY INTERNATIONAL. 1999;35(4):307-315
Nicergoline stimulates protein kinase C mediated α-secretase processing of the amyloid precursor protein in cultured human neuroblastoma SH-SY5Y cells
Cedazo-Minguez A; Bonecchi L; Winblad B; Post C; Wong EHF; Cowburn RF; Benatti L
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1999;1453(3):341-350
Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases
Vestling M; Cedazo-Mínguez A; Adem A; Wiehager B; Racchi M; Lannfelt L; Cowburn RF
Journal article: NEUROBIOLOGY OF AGING. 1996;17(4):s57
226 Effect of fibroblast growth factor and insulin on β-amyloid production in normal and familial Alzheimer's disease fibroblasts
Vigo-Pelfrey C; Cedazo-Minguez A; Cowburn RF; Jensen M; Lannfelt L; Johnston JA
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Silvia Maiolis forskargrupp

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Silvia Maiolis forskargrupp

Mekanismer bakom riskfaktorer för Alzheimers sjukdom (AD)

Apolipoprotein E, hyperkolesterolemi och AD

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Medarbetare och kontakt

Gruppledare

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Patricia Rodriguez forskning