Kodande och icke-kodande RNA i cancer – Per Hydbrings team

Vår forskning inriktas på kodande och icke-kodande RNA i cancer med fokus på RNA med en roll i resistens mot målriktade terapier i lungcancer. Genom att justera uttrycket av dessa RNA så kan vi påverka lungcancercellers känslighet till läkemedel som används i kliniken. Vi har etablerat metoder för att systematiskt karaktärisera RNA involverade i resistens till målriktade terapier. Vi har även erfarenhet av att formulera RNA-molekyler i nanopartiklar för systemisk leverans till in vivo modeller.

Publikationer

Utvalda publikationer

Article: EUROPEAN JOURNAL OF CANCER. 2020;132:24-34
An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer
Tsakonas G; Lewensohn R; Botling J; Ortiz-Villalon C; Micke P; Friesland S; Nord H; Lindskog M; Sandelin M; Hydbring P; Ekman S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2019;511(2):260-265
miR-100-5p confers resistance to ALK tyrosine kinase inhibitors Crizotinib and Lorlatinib in EML4-ALK positive NSCLC
Lai Y; Kacal M; Kanony M; Stukan I; Jatta K; Kis L; Norberg E; Vakifahmetoglu-Norberg H; Lewensohn R; Hydbring P; Ekman S
Article: LUNG CANCER. 2018;124:45-52
Exosomal RNA-profiling of pleural effusions identifies adenocarcinoma patients through elevated miR-200 and LCN2 expression
Hydbring P; De Petris L; Zhang Y; Branden E; Koyi H; Novak M; Kanter L; Haag P; Hurley J; Tadigotla V; Zhu B; Skog J; Viktorsson K; Ekman S; Lewensohn R
Article: CELL CYCLE. 2017;16(23):2241-2248
Identification of cell cycle-targeting microRNAs through genome- wide screens
Hydbring P; Wang Y; Bogorad RL; Yin H; Anderson DG; Li C; Sicinski P
Article: CANCER CELL. 2017;31(4):576-590.e8
Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers
Hydbring P; Wang Y; Fassl A; Li X; Matia V; Otto T; Choi YJ; Sweeney KE; Suski JM; Yin H; Bogorad RL; Goel S; Yuzugullu H; Kauffman KJ; Yang J; Jin C; Li Y; Floris D; Swanson R; Ng K; Sicinska E; Anders L; Zhao JJ; Polyak K; Anderson DG; Li C; Sicinski P
Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2016;17(5):280-292
Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases.
Hydbring P; Malumbres M; Sicinski P
Review: F1000RESEARCH. 2013;2:136
Clinical applications of microRNAs.
Hydbring P; Badalian-Very G
Article: CANCER CELL. 2012;22(4):438-451
The requirement for cyclin D function in tumor maintenance.
Choi YJ; Li X; Hydbring P; Sanda T; Stefano J; Christie AL; Signoretti S; Look AT; Kung AL; von Boehmer H; Sicinski P
Article: CANCER CELL. 2011;20(5):620-634
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.
Anders L; Ke N; Hydbring P; Choi YJ; Widlund HR; Chick JM; Zhai H; Vidal M; Gygi SP; Braun P; Sicinski P

Kodande och icke-kodande RNA i cancer – Per Hydbrings team

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