Könshormoner och könsskillnader i hjärnans sjukdomar – Ivan Nalvartes forskargrupp

Publikationer

Utvalda publikationer

• Review: ESSAYS IN BIOCHEMISTRY. 2021;65(6):913-925

  Estrogen receptors and the aging brain

  Maioli S; Leander K; Nilsson P; Nalvarte I
• Article: MOLECULAR PSYCHIATRY. 2021;26(11):6380-6393

  Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice

  Li X; Zhong H; Wang Z; Xiao R; Antonson P; Liu T; Wu C; Zou J; Wang L; Nalvarte I; Xu H; Warner M; Gustafsson J-A; Fan X
• Review: HORMONES AND AGING. 2021;116:313-326

  Estrogen receptor beta and neural development

  Nalvarte I; Varshney M; Inzunza J; Gustafsson J-A
• Article: NEUROENDOCRINOLOGY. 2021;111(1-2):27-44

  Motor Function Deficits in the Estrogen Receptor Beta Knockout Mouse: Role on Excitatory Neurotransmission and Myelination in the Motor Cortex

  Varshney MK; Yu NY-L; Katayama S; Li X; Liu T; Wu W-F; Tohonen V; Krjutskov K; Kere J; Fan X; Inzunza J; Gustafsson J-A; Nalvarte I
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(9):4902-4909

  Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERβ gene

  Warner M; Wu W-F; Montanholi L; Nalvarte I; Antonson P; Gustafsson J-A
• Editorial comment: BRAIN SCIENCES. 2020;10(2):E103-103

  Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives

  Nalvarte I
• Article: CELL REPORTS. 2018;25(13):3774-3785.e4

  LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

  Thomas DG; Doran AC; Fotakis P; Westerterp M; Antonson P; Jiang H; Jiang X-C; Gustafsson J-A; Tabas I; Tall AR
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(48):E10428-E10437

  Role of estrogen receptor beta in neural differentiation of mouse embryonic stem cells

  Varshney MK; Inzunza J; Lupu D; Ganapathy V; Antonson P; Ruegg J; Nalvarte I; Gustafsson J-A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(19):E3816-E3822

  Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate

  Wu W-F; Maneix L; Insunza J; Nalvarte I; Antonson P; Kere J; Yu NY-L; Tohonen V; Katayama S; Einarsdottir E; Krjutskov K; Dai Y-B; Huang B; Su W; Warner M; Gustafsson J-A

Alla gruppmedlemmars publikationer

• Journal article: F AND S SCIENCE. 2024;:S2666-335X(24)00056-9

  Transcriptomic profiling of the oocyte-cumulus-granulosa cell complex from estrogen receptor beta knockout mice.

  Töhönen V; Antonson P; Boggavarapu NR; Ali H; Motaholi LA; Gustafsson J-Å; Varshney M; Rodriguez-Wallberg KA; Katayama S; Nalvarte I; Inzunza J
• Journal article: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1472908

  Editorial: Steroid receptors in neuron and glia

  Le Menuet D; Charalampopoulos IN; Cunningham RL; Kalafatakis K; Nalvarte I
• Preprint: BIORXIV. 2024;BIORXIV

  ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer's disease.

  Demetriou A; Lindqvist B; Ali HG; Shamekh MM; Maioli S; Inzunza J; Varshney M; Nilsson P; Nalvarte I
• Article: SCIENCE ADVANCES. 2024;10(4):eadj1354

  CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice

  Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-Garcia LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Bjoerkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S
• Journal article: FERTILITY AND STERILITY. 2023;120(4):E194

  FUNCTIONAL ASSESSMENT OF HUMAN ENDOMETRIAL ORGANOID RESPONSIVENESS TO A SEQUENTIALLY CONTROLLED HORMONAL TREATMENT MIMICKING MENSTRUAL CYCLE

  Jiang Y; Varshney M; Palomares AR; Inzunza J; Acharya G; Nalvarte I; Rodriguez-Wallberg KA
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(15):12461

  Loss of ERβ in Aging LXRαβ Knockout Mice Leads to Colitis

  Song X; Wu W; Dai Y; Warner M; Nalvarte I; Antonson P; Varshney M; Gustafsson J-A
• Review: ENDOCRINOLOGY. 2023;164(6):bqad063

  ERβ in Granulosa Cell Tumors and Its Clinical Potential

  Birgersson M; Indukuri R; Antonson P; Nalvarte I; Archer A; Williams C
• Journal article: RECEPTORS. 2023;2(1):116-126

  Estrogen Receptor Knockout Mice and Their Effects on Fertility

  Nalvarte I; Antonson P
• Article: CELL DEATH & DISEASE. 2023;14(2):129

  Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses

  Raccosta L; Marinozzi M; Costantini S; Maggioni D; Ferreira LM; Corna G; Zordan P; Sorice A; Farinello D; Bianchessi S; Riba M; Lazarevic D; Provero P; Mack M; Bondanza A; Nalvarte I; Gustafsson J-A; Ranzani V; De Sanctis F; Ugel S; Baron S; Lobaccaro J-MA; Pontini L; Pacciarini M; Traversari C; Pagani M; Bronte V; Sitia G; Antonson P; Brendolan A; Budillon A; Russo V
• Review: NEURAL REGENERATION RESEARCH. 2022;17(9):1861-1866

  Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity

  Segura-Aguilar J; Mannervik B; Inzunza J; Varshney M; Nalvarte I; Munoz P
• Review: ANTIOXIDANTS. 2022;11(2):296

  Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase

  Segura-Aguilar J; Munoz P; Inzunza J; Varshney M; Nalvarte I; Mannervik B
• Review: ESSAYS IN BIOCHEMISTRY. 2021;65(6):913-925

  Estrogen receptors and the aging brain

  Maioli S; Leander K; Nilsson P; Nalvarte I
• Article: MOLECULAR PSYCHIATRY. 2021;26(11):6380-6393

  Loss of liver X receptor β in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice

  Li X; Zhong H; Wang Z; Xiao R; Antonson P; Liu T; Wu C; Zou J; Wang L; Nalvarte I; Xu H; Warner M; Gustafsson J-A; Fan X
• Article: STEM CELLS TRANSLATIONAL MEDICINE. 2021;10(7):987-995

  HSC and iPS cell-derived CAR-NK cells as reliable cell-based therapy solutions

  Arias J; Yu J; Varshney M; Inzunza J; Nalvarte I
• Article: NEUROTOXICITY RESEARCH. 2021;39(2):182-190

  Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes

  Valdes R; Armijo A; Munoz P; Hultenby K; Hagg A; Inzunza J; Nalvarte I; Varshney M; Mannervik B; Segura-Aguilar J
• Corrigendum: HELIYON. 2021;7(3):e06568

  Blood hormones and torque teno virus in peripheral blood mononuclear cells' (vol 6, e05535, 2020)

  Brundin PMA; Landgren B-M; Fjallstrom P; Johansson AF; Nalvarte I
• Article: STEM CELL RESEARCH. 2021;51:102193

  Generation of nonviral integration-free human iPS cell line KISCOi001-A from normal human fibroblasts, under defined xeno-free and feeder-free conditions

  Inzunza J; Arias-Fuenzalida J; Segura-Aguilar J; Nalvarte I; Varshney M
• Article: FRONTIERS IN ENDOCRINOLOGY. 2021;12:721813

  Expression of Sex Hormone Receptor and Immune Response Genes in Peripheral Blood Mononuclear Cells During the Menstrual Cycle

  Brundin PMA; Landgren B-M; Fjallstrom P; Shamekh MMM; Gustafsson J-A; Johansson AFF; Nalvarte I
• Review: HORMONES AND AGING. 2021;116:313-326

  Estrogen receptor beta and neural development

  Nalvarte I; Varshney M; Inzunza J; Gustafsson J-A
• Article: NEUROENDOCRINOLOGY. 2021;111(1-2):27-44

  Motor Function Deficits in the Estrogen Receptor Beta Knockout Mouse: Role on Excitatory Neurotransmission and Myelination in the Motor Cortex

  Varshney MK; Yu NY-L; Katayama S; Li X; Liu T; Wu W-F; Tohonen V; Krjutskov K; Kere J; Fan X; Inzunza J; Gustafsson J-A; Nalvarte I
• Article: HELIYON. 2020;6(11):e05535

  Blood hormones and torque teno virus in peripheral blood mononuclear cells

  Brundin PMA; Landgren B-M; Fjallstrom P; Johansson AF; Nalvarte I
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020;529(2):231-237

  Generation of an all-exon Esr2 deleted mouse line: Effects on fertility

  Antonson P; Apolinario LM; Shamekh MM; Humire P; Poutanen M; Ohlsson C; Nalvarte I; Gustafsson J-A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(9):4902-4909

  Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERβ gene

  Warner M; Wu W-F; Montanholi L; Nalvarte I; Antonson P; Gustafsson J-A
• Editorial comment: BRAIN SCIENCES. 2020;10(2):E103-103

  Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives

  Nalvarte I
• Article: BRAIN RESEARCH BULLETIN. 2019;150:75-85

  Citalopram attenuates social behavior deficits in the BTBR T⁺Itpr3^tf/J mouse model of autism

  Cai Y; Wang L; Nalvarte I; Xiao R; Li X; Fan X
• Meeting abstract: TOXICOLOGY LETTERS. 2018;295:S109-S110

  Fluoxetine affects midbrain neuronal specification and neurogenesis in vitro

  Lupu D; Varshney M; Nalvarte I; Insunza J; Loghin F; Ruegg J
• Article: MOLECULAR PHARMACOLOGY. 2018;94(4):1220-1231

  Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro

  Lupu D; Varshney MK; Mucs D; Inzunza J; Norinder U; Loghin F; Nalvarte I; Ruegg J
• Book chapter: EPIGENETICS AND ASSISTED REPRODUCTION. 2018;p. 99-114

  Intrinsic and Extrinsic Factors That Influence Epigenetics

  Nalvarte I; Rüegg J; Guerrero-Bosagna C
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(48):E10428-E10437

  Role of estrogen receptor beta in neural differentiation of mouse embryonic stem cells

  Varshney MK; Inzunza J; Lupu D; Ganapathy V; Antonson P; Ruegg J; Nalvarte I; Gustafsson J-A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(19):E3816-E3822

  Estrogen receptor β, a regulator of androgen receptor signaling in the mouse ventral prostate

  Wu W-F; Maneix L; Insunza J; Nalvarte I; Antonson P; Kere J; Yu NY-L; Tohonen V; Katayama S; Einarsdottir E; Krjutskov K; Dai Y-B; Huang B; Su W; Warner M; Gustafsson J-A
• Review: BRAIN SCIENCES. 2017;7(3):E24-24

  Genes, Gender, Environment, and Novel Functions of Estrogen Receptor Beta in the Susceptibility to Neurodevelopmental Disorders

  Varshney M; Nalvarte I
• Article: ONCOTARGET. 2016;7(35):56170-56182

  Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization

  Frei A; MacDonald G; Lund I; Gustafsson J-A; Hynes NE; Nalvarte I
• Journal article: ENDOCRINE DISRUPTORS. 2016;4(1):e1184775

  Effects of pre- and post-natal exposure to bisphenol A on the stress system

  Kitraki E; Nalvarte I; Alavian-Ghavanini A; Rüegg J
• Article: REPRODUCTION. 2016;151(3):253-259

  Estrogen rleceptor β controls MMP-19 expression in mouse ovaries during ovulation

  Nalvarte I; Tohonen V; Lindeberg M; Varshney M; Gustafsson J-A; Inzunza J
• Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2015;417(C):191-199

  Developmental exposure to bisphenol A alters expression and DNA methylation of Fkbp5, an important regulator of the stress response

  Kitraki E; Nalvarte I; Alavian-Ghavanini A; Rueegg J
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015;466(4):650-655

  Identification of proteins highly expressed in uterine fluid from mice with hydrometra

  Antonson P; Nalvarte I; Varshney M; Xu L; Windahl SH; Humire P; Ohlsson C; Gustafsson J-A; Dahlman-Wright K
• Article: BIOSCIENCE REPORTS. 2015;35(6):e00269

  The expression and activity of thioredoxin reductase 1 splice variants v1 and v2 regulate the expression of genes associated with differentiation and adhesion

  Nalvarte I; Damdimopoulos AE; Ruegg J; Spyrou G
• Corrigendum: SCIENCE SIGNALING. 2014;7(333)

  Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis (vol 7, er4, 2014)

  MacDonald G; Nalvarte I; Smirnova T; Vecchi M; Aceto N; Doelemeyer A; Frei A; Lienhard S; Wyckoff J; Hess D; Seebacher J; Keusch JJ; Gut H; Salaun D; Mazzarol G; Disalvatore D; Bentires-Alj M; Di Fiore PP; Badache A; Hynes NE
• Article: SCIENCE SIGNALING. 2014;7(329):ra56

  Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis

  MacDonald G; Nalvarte I; Smirnova T; Vecchi M; Aceto N; Dolemeyer A; Frei A; Lienhard S; Wyckoff J; Hess D; Seebacher J; Keusch JJ; Gut H; Salaun D; Mazzarol G; Disalvatore D; Bentires-Alj M; Di Fiore PP; Badache A; Hynes NE
• Article: EMBO MOLECULAR MEDICINE. 2013;5(9):1335-1350

  Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells

  Gattelli A; Nalvarte I; Boulay A; Roloff TC; Schreiber M; Carragher N; Macleod KK; Schlederer M; Lienhard S; Kenner L; Torres-Arzayus MI; Hynes NE
• Meeting abstract: CANCER RESEARCH. 2012;72:pd01-06-pd01-06

  Inhibition of the Ret receptor tyrosine kinase in combination with endocrine therapy impacts on migration and metastatic potential of estrogen receptor positive breast cancer models.

  Hynes NE; Gattelli A; Nalvarte I; Roloff T
• Article: MOLECULAR ENDOCRINOLOGY. 2012;26(4):619-629

  The rs3743205 SNP Is Important for the Regulation of the Dyslexia Candidate Gene DYX1C1 by Estrogen Receptor β and DNA Methylation

  Tammimies K; Tapia-Paez I; Rueegg J; Rosin G; Kere J; Gustafsson J-A; Nalvarte I
• Book chapter: HORMONE-DISRUPTIVE CHEMICAL CONTAMINANTS IN FOOD. 2011;p. 44-69

  Chapter 4

  Damdimopoulou P; Weis S; Nalvarte I; Rüegg J
• Article: MOLECULAR & CELLULAR PROTEOMICS. 2010;9(7):1411-1422

  Proteomics Analysis of the Estrogen Receptor α Receptosome

  Nalvarte I; Schwend T; Gustafsson J-A
• Journal article: MOLECULAR PSYCHIATRY. 2009;14(2):117

  Abnormally large, heavy brain with a decreased number of apoptotic cells in CYP7B1 knockout mice

  Sugiyama N; Andersson S; Lathe R; Fan X; Alonso-Magdalena P; Schwend T; Nalvarte I; Warner M; Gustafsson J-Å
• Article: MOLECULAR PSYCHIATRY. 2009;14(2):223-117

  Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain

  Sugiyama N; Andersson S; Lathe R; Fan X; Alonso-Magdalena P; Schwend T; Nalvarte I; Warner M; Gustafsson J-A
• Article: BIOLOGY OF THE CELL. 2007;99(12):677-687

  Overexpression of thioredoxin reductase 1 inhibits migration of HEK-293 cells

  Sroka J; Antosik A; Czyz J; Nalvarte I; Ollsson JM; Spyrou G; Madeja Z
• Thesis / dissertation: 2006

  Functional characterization of cytosolic and mitochondrial thioredoxin reductases

  Nalvarte, Ivan
• Meeting abstract: TOXICOLOGY LETTERS. 2006;164:S299

  The selenoprotein thioredoxin reductase is involved in expression of several genes associated with differentiation, adhesion and migration

  Nalvarte I; Spyrou G
• Article: BIOCHEMICAL PHARMACOLOGY. 2005;69(12):1765-1772

  The role of thioredoxin reductase activity in selenium-induced cytotoxicity

  Madeja Z; Sroka J; Nyström C; Björkhem-Bergman L; Nordman T; Damdimopoulos A; Nalvarte I; Eriksson LC; Spyrou G; Olsson JM; Björnstedt M
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(52):54510-54517

  Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells -: Effect on cell growth and differentiation

  Nalvarte I; Damdimopoulos AE; Nystöm C; Nordman T; Miranda-Vizuete A; Olsson JM; Eriksson L; Björnstedt M; Arnér ESJ; Spyrou G
• Article: FREE RADICAL BIOLOGY AND MEDICINE. 2004;36(10):1270-1278

  Human mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition

  Nalvarte I; Damdimopoulos AE; Spyrou G
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2004;36:S73

  The human selenoprotein mitochondrial thioredoxin reductase reduces cytochrome c and confers resistance to complex III inhibition

  Nalvarte I; Damdimopoulos AE; Spyrou G
• Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2004;36:S14

  Novel functions of the mammalian thioredoxin systems

  Nalvarte I; Damdimopoulos A; Cunnea P; Psarra AM; Bjornstedt M; Olsson JM; Spyrou G
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(4):2141-2146

  The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone -: A novel mechanism for defense against oxidative stress

  Xia L; Nordman T; Olsson JM; Damdimopoulos A; Björkhem-Bergman L; Nalvarte I; Eriksson LC; Arnér ESJ; Spyrou G; Björnstedt M
• Conference publication: FREE RADICAL RESEARCH. 2003;37:44

  Novel functions of the mammalian thioredoxin systems

  Nalvarte I; Damdimopoulos A; Cunnea P; Psarra AM; Bjornstedt M; Olsson JM; Spyrou G
• Published conference paper: BIOFACTORS. 2003;18(1-4):45-50

  Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase

  Nordman T; Xia L; Björkhem-Bergman L; Damdimopoulos A; Nalvarte I; Arnér ESJ; Spyrou G; Eriksson LC; Björnstedt M; Olsson JM
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Medarbetare och kontakt

Gruppledare

• 

  Ivan Nalvarte

  Senior Forskare | Docent

  E-postadress ivan.nalvarte@ki.se

Alla medlemmar i gruppen

• 

  Heba Ali

  Anknuten till Forskning

  E-postadress heba.ali@ki.se
• 

  Aphrodite Demetriou

  Doktorand

  E-postadress aphrodite.demetriou@ki.se
• Patricia Muñoz

  Anknuten till Forskning

  E-postadress patricia.munoz@ki.se
• 

  Ivan Nalvarte

  Senior Forskare | Docent

  E-postadress ivan.nalvarte@ki.se
• Michael Rossiter

  Anknuten till Forskning

  E-postadress michael.rossiter@ki.se

Besöksadress

Karolinska Institutet, NVS, Neurogeriatrik, Akademiska Stråket 1, Solna, 171 64, Sweden

Postadress

Karolinska Institutet, NVS, Neurogeriatrik, Visionsgatan 4, J9:20, Solna, 171 64, Sweden