Nils-Göran Larssons forskargrupp

The mitochondrion is a key player in cellular function and dysfunctional mitochondria have been implicated in a number of disorders as well as in the process of normal ageing. Our research group is interested in fundamental questions related to mitochondrial biology. How is the number and the function of mitochondria regulated? What happens in a cell with dysfunctional mitochondria? How does mitochondrial dysfunction cause human disease?

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Institutionen för medicinsk biokemi och biofysik

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Utvalda publikationer

Article: CELL METABOLISM. 2023;35(10):1799-1813.e7
Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes
Milenkovic D; Misic J; Hevler JF; Molinie T; Chung I; Atanassov I; Li X; Filograna R; Mesaros A; Mourier A; Heck AJR; Hirst J; Larsson N-G
Article: PLOS GENETICS. 2023;19(1):e1010573
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA
Kremer LS; Bozhilova LV; Rubalcava-Gracia D; Filograna R; Upadhyay M; Koolmeister C; Chinnery PF; Larsson N-G
Article: NUCLEIC ACIDS RESEARCH (NAR). 2022;50(15):8749-8766
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion
Misic J; Milenkovic D; Al-Behadili A; Xie X; Jiang M; Jiang S; Filograna R; Koolmeister C; Siira SJ; Jenninger L; Filipovska A; Clausen AR; Caporali L; Valentino ML; La Morgia C; Carelli V; Nicholls TJ; Wredenberg A; Falkenberg M; Larsson N-G
Article: PLOS GENETICS. 2022;18(5):e1010190
Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction
Milenkovic D; Sanz-Moreno A; Calzada-Wack J; Rathkolb B; Veronica Amarie O; Gerlini R; Aguilar-Pimentel A; Misic J; Simard M-LS; Wolf ET; Fuchs HS; Gailus-Durner VT; de Angelis MHS; Larsson N-GT
Article: EMBO REPORTS. 2022;23(1):e53054
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen
Mennuni M; Filograna R; Felser A; Bonekamp NA; Giavalisco P; Lytovchenko O; Larsson N-G
Article: LIFE SCIENCE ALLIANCE. 2021;4(11):e202101034
High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo
Bonekamp NA; Jiang M; Motori E; Villegas RG; Koolmeister C; Atanassov I; Mesaros A; Park CB; Larsson N-G
Article: PLOS GENETICS. 2021;17(9):e1009822
Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response
Filograna R; Lee S; Tiklova K; Mennuni M; Jonsson V; Ringner M; Gillberg L; Sopova E; Shupliakov O; Koolmeister C; Olson L; Perlmann T; Larsson N-G
Article: SCIENCE ADVANCES. 2021;7(27):eabf8631
The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication
Jiang M; Xie X; Zhu X; Jiang S; Milenkovic D; Misic J; Shi Y; Tandukar N; Li X; Atanassov I; Jenninger L; Hoberg E; Albarran-Gutierrez S; Szilagyi Z; Macao B; Siira SJ; Carelli V; Griffith JD; Gustafsson CM; Nicholls TJ; Filipovska A; Larsson N-G; Falkenberg M
Article: NATURE. 2020;588(7839):712-716
Small-molecule inhibitors of human mitochondrial DNA transcription
Bonekamp NA; Peter B; Hillen HS; Felser A; Bergbrede T; Choidas A; Horn M; Unger A; Di Lucrezia R; Atanassov I; Li X; Koch U; Menninger S; Boros J; Habenberger P; Giavalisco P; Cramer P; Denzel MS; Nussbaumer P; Klebl B; Falkenberg M; Gustafsson CM; Larsson N-G
Article: SCIENCE ADVANCES. 2020;6(35):eaba8271
Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction
Motori E; Atanassov I; Kochan SMV; Folz-Donahue K; Sakthivelu V; Giavalisco P; Toni N; Puyal J; Larsson N-G
Editorial comment: NATURE METABOLISM. 2020;2(8):673-675
Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos
Sharma S; Koolmeister C; Phong T; Nilsson AK; Larsson N-G; Chabes A
Article: EMBO MOLECULAR MEDICINE. 2020;12(7):e11659
FBXL4 deficiency increases mitochondrial removal by autophagy
Alsina D; Lytovchenko O; Schab A; Atanassov I; Schober FA; Jiang M; Koolmeister C; Wedell A; Taylor RW; Wredenberg A; Larsson N-G

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Nils-Göran Larssons forskargrupp

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