Nils-Göran Larssons forskargrupp

The mitochondrion is a key player in cellular function and dysfunctional mitochondria have been implicated in a number of disorders as well as in the process of normal ageing. Our research group is interested in fundamental questions related to mitochondrial biology. How is the number and the function of mitochondria regulated? What happens in a cell with dysfunctional mitochondria? How does mitochondrial dysfunction cause human disease?

En del av Institutionen för medicinsk biokemi och biofysik

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Article: CELL METABOLISM. 2023;35(10):1799-1813.e7

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes.

Milenkovic D; Misic J; Hevler JF; Molinié T; Chung I; Atanassov I; Li X; Filograna R; Mesaros A; Mourier A; Heck AJR; Hirst J; Larsson N-G
Article: PLOS GENETICS. 2023;19(1):e1010573

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

Kremer LS; Bozhilova LV; Rubalcava-Gracia D; Filograna R; Upadhyay M; Koolmeister C; Chinnery PF; Larsson N-G
Article: NUCLEIC ACIDS RESEARCH. 2022;50(15):8749-8766

Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion.

Misic J; Milenkovic D; Al-Behadili A; Xie X; Jiang M; Jiang S; Filograna R; Koolmeister C; Siira SJ; Jenninger L; Filipovska A; Clausen AR; Caporali L; Valentino ML; La Morgia C; Carelli V; Nicholls TJ; Wredenberg A; Falkenberg M; Larsson N-G
Article: PLOS GENETICS. 2022;18(5):e1010190

Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction.

Milenkovic D; Sanz-Moreno A; Calzada-Wack J; Rathkolb B; Veronica Amarie O; Gerlini R; Aguilar-Pimentel A; Misic J; Simard M-L; Wolf E; Fuchs H; Gailus-Durner V; de Angelis MH; Larsson N-G
Article: EMBO REPORTS. 2022;23(1):e53054

Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen.

Mennuni M; Filograna R; Felser A; Bonekamp NA; Giavalisco P; Lytovchenko O; Larsson N-G
Article: LIFE SCIENCE ALLIANCE. 2021;4(11):e202101034

High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo.

Bonekamp NA; Jiang M; Motori E; Garcia Villegas R; Koolmeister C; Atanassov I; Mesaros A; Park CB; Larsson N-G
Article: PLOS GENETICS. 2021;17(9):e1009822

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.

Filograna R; Lee S; Tiklová K; Mennuni M; Jonsson V; Ringnér M; Gillberg L; Sopova E; Shupliakov O; Koolmeister C; Olson L; Perlmann T; Larsson N-G
Article: SCIENCE ADVANCES. 2021;7(27):eabf8631

The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication.

Jiang M; Xie X; Zhu X; Jiang S; Milenkovic D; Misic J; Shi Y; Tandukar N; Li X; Atanassov I; Jenninger L; Hoberg E; Albarran-Gutierrez S; Szilagyi Z; Macao B; Siira SJ; Carelli V; Griffith JD; Gustafsson CM; Nicholls TJ; Filipovska A; Larsson N-G; Falkenberg M
Article: NATURE. 2020;588(7839):712-716

Small-molecule inhibitors of human mitochondrial DNA transcription.

Bonekamp NA; Peter B; Hillen HS; Felser A; Bergbrede T; Choidas A; Horn M; Unger A; Di Lucrezia R; Atanassov I; Li X; Koch U; Menninger S; Boros J; Habenberger P; Giavalisco P; Cramer P; Denzel MS; Nussbaumer P; Klebl B; Falkenberg M; Gustafsson CM; Larsson N-G
Article: SCIENCE ADVANCES. 2020;6(35):eaba8271

Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction.

Motori E; Atanassov I; Kochan SMV; Folz-Donahue K; Sakthivelu V; Giavalisco P; Toni N; Puyal J; Larsson N-G
Editorial comment: NATURE METABOLISM. 2020;2(8):673-675

Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos.

Sharma S; Koolmeister C; Tran P; Nilsson AK; Larsson N-G; Chabes A
Article: EMBO MOLECULAR MEDICINE. 2020;12(7):e11659

FBXL4 deficiency increases mitochondrial removal by autophagy.

Alsina D; Lytovchenko O; Schab A; Atanassov I; Schober FA; Jiang M; Koolmeister C; Wedell A; Taylor RW; Wredenberg A; Larsson N-G

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Nils-Göran Larssons forskargrupp

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