Nils-Göran Larssons forskargrupp

The mitochondrion is a key player in cellular function and dysfunctional mitochondria have been implicated in a number of disorders as well as in the process of normal ageing. Our research group is interested in fundamental questions related to mitochondrial biology. How is the number and the function of mitochondria regulated? What happens in a cell with dysfunctional mitochondria? How does mitochondrial dysfunction cause human disease?

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Utvalda publikationer

Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2025;1872(6):119955
In vivo composition of the mitochondrial nucleoid in mice
Garcia-Villegas R; Odenthal F; Giannoula Y; Bonekamp NA; Kuehl I; Park CB; Spahr H; Motori E; Levander F; Larsson N-G
Article: NATURE. 2025;642(8067):501-507
Small molecules restore mutant mitochondrial DNA polymerase activity
Valenzuela S; Zhu X; Macao B; Stamgren M; Geukens C; Charifson PS; Kern G; Hoberg E; Jenninger L; Gruszczyk AV; Lee S; Johansson KAS; Fuste JM; Shi Y; Kerns SJ; Arabanian L; Botella GM; Ekstroem S; Green J; Griffin AM; Pardo-Hernandez C; Keating TA; Kuppers-Munther B; Larsson N-G; Phan C; Posse V; Jones JE; Xie X; Giroux S; Gustafsson CM; Falkenberg M
Article: SCIENCE ADVANCES. 2024;10(44):eadp3481
High mitochondrial DNA levels accelerate lung adenocarcinoma progression
Mennuni M; Wilkie SE; Michon P; Alsina D; Filograna R; Lindberg M; Sanin DE; Rosenberger F; Schaaf A; Larsson E; Pearce EL; Larsson N-G
Article: NUCLEIC ACIDS RESEARCH. 2024;52(18):11266-11282
LRPPRC and SLIRP synergize to maintain sufficient and orderly mammalian mitochondrial translation
Rubalcava-Gracia D; Bubb K; Levander F; Burr SP; August AV; Chinnery PF; Koolmeister C; Larsson N-G
Article: NATURE METABOLISM. 2024;6(6):1024-1035
Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity
Jiang S; Yuan T; Rosenberger FA; Mourier A; Dragano NRV; Kremer LS; Rubalcava-Gracia D; Hansen FM; Borg M; Mennuni M; Filograna R; Alsina D; Misic J; Koolmeister C; Papadea P; de Angelis MH; Ren L; Andersson O; Unger A; Bergbrede T; Di Lucrezia R; Wibom R; Zierath JR; Krook A; Giavalisco P; Mann M; Larsson N-G
Article: CELL METABOLISM. 2023;35(10):1799-1813.e7
Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes
Milenkovic D; Misic J; Hevler JF; Molinie T; Chung I; Atanassov I; Li X; Filograna R; Mesaros A; Mourier A; Heck AJR; Hirst J; Larsson N-G
Article: PLOS GENETICS. 2023;19(1):e1010573
A role for BCL2L13 and autophagy in germline purifying selection of mtDNA
Kremer LS; Bozhilova LV; Rubalcava-Gracia D; Filograna R; Upadhyay M; Koolmeister C; Chinnery PF; Larsson N-G
Article: NUCLEIC ACIDS RESEARCH. 2022;50(15):8749-8766
Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion
Misic J; Milenkovic D; Al-Behadili A; Xie X; Jiang M; Jiang S; Filograna R; Koolmeister C; Siira SJ; Jenninger L; Filipovska A; Clausen AR; Caporali L; Valentino ML; La Morgia C; Carelli V; Nicholls TJ; Wredenberg A; Falkenberg M; Larsson N-G
Article: PLOS GENETICS. 2022;18(5):e1010190
Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction
Milenkovic D; Sanz-Moreno A; Calzada-Wack J; Rathkolb B; Veronica Amarie O; Gerlini R; Aguilar-Pimentel A; Misic J; Simard M-LS; Wolf ET; Fuchs HS; Gailus-Durner VT; de Angelis MHS; Larsson N-GT
Article: EMBO REPORTS. 2022;23(1):e53054
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen
Mennuni M; Filograna R; Felser A; Bonekamp NA; Giavalisco P; Lytovchenko O; Larsson N-G
Article: LIFE SCIENCE ALLIANCE. 2021;4(11):e202101034
High levels of TFAM repress mammalian mitochondrial DNA transcription in vivo
Bonekamp NA; Jiang M; Motori E; Villegas RG; Koolmeister C; Atanassov I; Mesaros A; Park CB; Larsson N-G
Article: PLOS GENETICS. 2021;17(9):e1009822
Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response
Filograna R; Lee S; Tiklova K; Mennuni M; Jonsson V; Ringner M; Gillberg L; Sopova E; Shupliakov O; Koolmeister C; Olson L; Perlmann T; Larsson N-G
Article: NATURE METABOLISM. 2021;3(5):636-650
Cellular pyrimidine imbalance triggers mitochondrial DNA-dependent innate immunity
Sprenger H-G; MacVicar T; Bahat A; Fiedler KU; Hermans S; Ehrentraut D; Ried K; Milenkovic D; Bonekamp N; Larsson N-G; Nolte H; Giavalisco P; Langer T
Article: NATURE. 2020;588(7839):712-716
Small-molecule inhibitors of human mitochondrial DNA transcription
Bonekamp NA; Peter B; Hillen HS; Felser A; Bergbrede T; Choidas A; Horn M; Unger A; Di Lucrezia R; Atanassov I; Li X; Koch U; Menninger S; Boros J; Habenberger P; Giavalisco P; Cramer P; Denzel MS; Nussbaumer P; Klebl B; Falkenberg M; Gustafsson CM; Larsson N-G
Article: SCIENCE ADVANCES. 2020;6(35):eaba8271
Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction
Motori E; Atanassov I; Kochan SMV; Folz-Donahue K; Sakthivelu V; Giavalisco P; Toni N; Puyal J; Larsson N-G

Nils-Göran Larssons forskargrupp

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