Oscar Fernandez-Capetillos forskargrupp

Fernández-Capetillos forskargrupp använder sig av cellbaserade fenotypiska screeningsmetoder med syftet att utveckla nya läkemedel. Då målinriktad läkemedelsutveckling länge varit i fokus inom läkemedelutveckling har fenotypiska screeningsmetoder förummats, men de senaste åren har metoden lett till några av de viktigaste medicinska framstegen för vårt samhälle. Med hjälp av automatiserad mikroskopi designar laboratoriet fenotypiska screener som syftar till att efterlikna olika sjukdomstillstånd.

Publikationer

Utvalda publikationer

Article: MOLECULAR THERAPY. 2024;32(9):3012-3024
Discovery of a novel inhibitor of macropinocytosis with antiviral activity
Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Haggblad M; Ilmain J; Wright SC; Murga M; Schlegel J; Jarvius M; Lapins M; Sezgin E; Bhabha G; Lauschke VM; Carreras-Puigvert J; Lafarga M; Klingstrom J; Huhn D; Fernandez-Capetillo O
Article: EBIOMEDICINE. 2024;103:105124
The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ γ
Li X; Hernandez I; Koyuncu S; Haeggblad M; Lidemalm L; Abbas AA; Bendeguz S; Goebloes A; Brautigam L; Lucas JJ; Carreras-Puigvert J; Huehn D; Pircs K; Vilchez D; Fernandez-Capetillo O
Preprint: BIORXIV. 2023
Discovery of a novel inhibitor of macropinocytosis with antiviral activity
Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Häggblad M; Ilmain J; Wright S; Murga M; Shlegel J; Sezgin E; Bhabha G; Lauschke V; Lafarga M; Klingström J; Huhn D; Fernandez-Capetillo O
Article: MICROPUBLICATION BIOLOGY. 2023;2023:10.17912/micropub.biology
A chemical screen underscores the essential role of STAT1-dependent IFNγ signaling to regulate HLA-I expression in cancer cells.
Barz M; Porebski B; Panshikar P; Häggbladd M; Hühn D; Fernandez-Capetillo O
Article: NATURE COMMUNICATIONS. 2022;13(1):155
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM
Article: MOLECULAR ONCOLOGY. 2022;16(1):148-165
Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells
Huhn D; Marti-Rodrigo P; Mouron S; Hansel C; Tschapalda K; Porebski B; Haggblad M; Lidemalm L; Quintela-Fandino M; Carreras-Puigvert J; Fernandez-Capetillo O
Article: PLOS BIOLOGY. 2021;19(5):e3001263
A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors
Corman A; Kanellis DC; Michalska P; Haggblad M; Lafarga V; Bartek J; Carreras-Puigvert J; Fernandez-Capetillo O
Article: CELL CHEMICAL BIOLOGY. 2019;26(2):235-243.e5
A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats
Corman A; Jung B; Haggblad M; Brautigam L; Lafarga V; Lidemalm L; Huhn D; Carreras-Puigvert J; Fernandez-Capetillo O
Article: MOLECULAR CELL. 2016;62(2):307-313
A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors
Ruiz S; Mayor-Ruiz C; Lafarga V; Murga M; Vega-Sendino M; Ortega S; Fernandez-Capetillo O
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2016;23(4):270-277
USP7 is a SUMO deubiquitinase essential for DNA replication
Lecona E; Rodriguez-Acebes S; Specks J; Lopez-Contreras AJ; Ruppen I; Murga M; Munoz J; Mendez J; Fernandez-Capetillo O
Article: EMBO JOURNAL. 2015;34(21):2604-2619
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity
Jacome A; Gutierrez-Martinez P; Schiavoni F; Tenaglia E; Martinez P; Rodriguez-Acebes S; Lecona E; Murga M; Mendez J; Blasco MA; Fernandez-Capetillo O

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