Cancerbioinformatik – Nick Tobins team

Publikationer

Utvalda publikationer

• Article: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(35):4071-4082

  Twenty-Year Benefit From Adjuvant Goserelin and Tamoxifen in Premenopausal Patients With Breast Cancer in a Controlled Randomized Clinical Trial

  Johansson A; Dar H; Veer LJVT; Tobin NP; Perez-Tenorio G; Nordenskjold A; Johansson U; Hartman J; Skoog L; Yau C; Benz CC; Esserman LJ; Stal O; Nordenskjold B; Fornander T; Lindstrom LS
• Article: NPJ PRECISION ONCOLOGY. 2022;6(1):59

  Reclassifying tumour cell cycle activity in terms of its tissue of origin

  Lundberg A; Yi JJJ; Lindstrom LS; Tobin NP
• Article: INTERNATIONAL JOURNAL OF CANCER. 2022;150(12):2072-2082

  Clinical and molecular characteristics of estrogen receptor-positive ultralow risk breast cancer tumors identified by the 70-gene signature

  Johansson A; Yu NY; Iftimi A; Tobin NP; 't Veer L; Nordenskjold B; Benz CC; Fornander T; Perez-Tenorio G; Stal O; Esserman LJ; Yau C; Lindstrom LS
• Article: PLOS COMPUTATIONAL BIOLOGY. 2022;18(3):e1010020

  Survival analysis of pathway activity as a prognostic determinant in breast cancer

  Jeuken GS; Tobin NP; Kall L
• Article: EUROPEAN JOURNAL OF CANCER. 2022;162:194-205

  Interval breast cancer is associated with interferon immune response

  Ugalde-Morales E; Grassmann F; Humphreys K; Li J; Eriksson M; Tobin NP; Lindstrom LS; Vallon-Christersson J; Borg A; Hall P; Czene K
• Article: GENETICS IN MEDICINE. 2022;24(1):157-169

  Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma

  Yang M; Johnsson P; Brautigam L; Yang XR; Thrane K; Gao J; Tobin NP; Zhou Y; Yu R; Nagy N; Engstrom PG; Tuominen R; Eriksson H; Lundeberg J; Tucker MA; Goldstein AM; Egyhazi-Brage S; Zhao J; Cao Y; Hoiom V
• Article: CELL REPORTS. 2021;36(8):109616

  The Amot/integrin protein complex transmits mechanical forces required for vascular expansion

  Zhang Y; Zhang Y; Kameishi S; Barutello G; Zheng Y; Tobin NP; Nicosia J; Hennig K; Chiu DK-C; Balland M; Barker TH; Cavallo F; Holmgren L
• Article: CANCERS. 2021;13(5):1175

  CD11c-CD8 Spatial Cross Presentation: A Novel Approach to Link Immune Surveillance and Patient Survival in Soft Tissue Sarcoma

  Su Y; Tsagkozis P; Papakonstantinou A; Tobin NP; Gultekin O; Malmerfelt A; Ingelshed K; Neo SY; Lundquist J; Chaabane W; Nisancioglu MH; Leiss LW; Ostman A; Bergh J; Sedimbi S; Lehti K; Lundqvist A; Stragliotto CL; Haglund F; Ehnman M
• Article: INTERNATIONAL JOURNAL OF CANCER. 2021;148(4):884-894

  Association between breast cancer risk and disease aggressiveness: Characterizing underlying gene expression patterns

  Ugalde-Morales E; Grassmann F; Humphreys K; Li J; Eriksson M; Tobin NP; Borg A; Vallon-Christersson J; Hall P; Czene K
• Article: ONCOGENE. 2020;39(32):5430-5440

  A pan-cancer analysis of the frequency of DNA alterations across cell cycle activity levels

  Lundberg A; Lindstrom LS; Parker JS; Loverli E; Perou CM; Bergh J; Tobin NP
• Article: MOLECULAR ONCOLOGY. 2020;14(5):951-963

  Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease

  Zerdes I; Sifakis EG; Matikas A; Chretien S; Tobin NP; Hartman J; Rassidakis GZ; Bergh J; Foukakis T
• Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198

  CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment

  Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
• Article: GLIA. 2020;68(2):316-327

  Astrocytes enhance glioblastoma growth

  Mega A; Nilsen MH; Leiss LW; Tobin NP; Miletic H; Sleire L; Strell C; Nelander S; Krona C; Hagerstrand D; Enger PO; Nister M; Ostman A
• Article: CANCERS. 2019;11(10):E1479-1479

  STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer

  Zerdes I; Wallerius M; Sifakis EG; Wallmann T; Betts S; Bartish M; Tsesmetzis N; Tobin NP; Coucoravas C; Bergh J; Rassidakis GZ; Rolny C; Foukakis T
• Article: EBIOMEDICINE. 2019;48:212-223

  Generation of in situ sequencing based OncoMaps to spatially resolve gene expression profiles of diagnostic and prognostic markers in breast cancer

  Svedlund J; Strell C; Qian X; Zilkens KJC; Tobin NP; Bergh J; Sieuwerts AM; Nilsson M
• Article: JAMA ONCOLOGY. 2019;5(9):1304-1309

  Assessment of Long-term Distant Recurrence-Free Survival Associated With Tamoxifen Therapy in Postmenopausal Patients With Luminal A or Luminal B Breast Cancer

  Yu NY; Iftimi A; Yau C; Tobin NP; van 't Veer L; Hoadley KA; Benz CC; Nordenskjold B; Fornander T; Stal O; Czene K; Esserman LJ; Lindstrom LS
• Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2019;111(9):983-995

  Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ

  Strell C; Paulsson J; Jin S-B; Tobin NP; Mezheyeuski A; Roswall P; Mutgan C; Mitsios N; Johansson H; Wickberg SM; Svedlund J; Nilsson M; Hall P; Mulder J; Radisky DC; Pietras K; Bergh J; Lendahl U; Warnberg F; Ostman A
• Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2019;68(6):927-936

  An immunosuppressive macrophage profile attenuates the prognostic impact of CD20-positive B cells in human soft tissue sarcoma

  Tsagozis P; Augsten M; Zhang Y; Li T; Hesla A; Bergh J; Haglund F; Tobin NP; Ehnman M
• Article: BREAST CANCER RESEARCH. 2019;21(1):36

  Separation of breast cancer and organ microenvironment transcriptomes in metastases

  Alzubi MA; Turner TH; Olex AL; Sohal SS; Tobin NP; Recio SG; Bergh J; Hatschek T; Parker JS; Sartorius CA; Perou CM; Dozmorov MG; Harrell JC
• Article: BREAST CANCER RESEARCH. 2019;21(1):34

  The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours

  Lundberg A; Lindstroem LS; Li J; Harrell JC; Darai-Ramqvist E; Sifakis EG; Foukakis T; Perou CM; Czene K; Bergh J; Tobin NP
• Article: JOURNAL OF CLINICAL PATHOLOGY. 2018;71(9):787-794

  Prognostic value of Ki67 analysed by cytology or histology in primary breast cancer

  Robertson S; Stalhammar G; Darai-Ramqvist E; Rantalainen M; Tobin NP; Bergh J; Hartman J
• Article: BRITISH JOURNAL OF CANCER. 2018;118(4):480-488

  Immune gene expression and response to chemotherapy in advanced breast cancer

  Foukakis T; Lovrot J; Matikas A; Zerdes I; Lorent J; Tobin N; Suzuki C; Brage SE; Carlsson L; Einbeigi Z; Linderholm B; Loman N; Malmberg M; Ferno M; Skoog L; Bergh J; Hatschek T
• Article: BMC CANCER. 2018;18(1):174

  Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

  Kjallquist U; Erlandsson R; Tobin NP; Alkodsi A; Ullah I; Stalhammar G; Karlsson E; Hatschek T; Hartman J; Linnarsson S; Bergh J
• Article: CLINICAL CANCER RESEARCH. 2017;23(24):7512-7520

  Gene Expression Signatures and Immunohistochemical Subtypes Add Prognostic Value to Each Other in Breast Cancer Cohorts

  Lundberg A; Lindstrom LS; Harrell JC; Falato C; Carlson JW; Wright PK; Foukakis T; Perou CM; Czene K; Bergh J; Tobin NP
• Article: CLINICAL CANCER RESEARCH. 2017;23(23):7225-7231

  PAM50 Provides Prognostic Information When Applied to the Lymph Node Metastases of Advanced Breast Cancer Patients

  Tobin NP; Lundberg A; Lindstrom LS; Harrell JC; Foukakis T; Carlsson L; Einbeigi Z; Linderholm BK; Loman N; Malmberg M; Ferno M; Czene K; Perou CM; Bergh J; Hatschek T
• Article: JAMA ONCOLOGY. 2017;3(11):1503-1510

  Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades

  Esserman LJ; Yau C; Thompson CK; van't Veer LJ; Borowsky AD; Hoadley KA; Tobin NP; Nordenskjold B; Fornander T; Stal O; Benz CC; Lindstrom LS
• Article: EUROPEAN JOURNAL OF CANCER. 2017;84:278-289

  Breast cancer in young women and prognosis: How important are proliferation markers?

  Fredholm H; Magnusson K; Lindstrom LS; Tobin NP; Lindman H; Bergh J; Holmberg L; Ponten F; Frisell J; Fredriksson I
• Article: CLINICAL CANCER RESEARCH. 2017;23(10):2584-2592

  Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes

  Li J; Ivansson E; Klevebring D; Tobin NP; Lindstrom LS; Holm J; Prochazka G; Cristando C; Palmgren J; Tornberg S; Humphreys K; Hartman J; Frisell J; Rantalainen M; Lindberg J; Hall P; Bergh J; Gronberg H; Czene K
• Article: SCIENTIFIC REPORTS. 2017;7(1):1089

  Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer

  Kruger K; Wik E; Knutsvik G; Nalwoga H; Klingen TA; Arnes JB; Chen Y; Mannelqvist M; Dimitrakopoulou K; Stefansson IM; Birkeland E; Aas T; Tobin NP; Jonassen I; Bergh J; Foulkes WD; Akslen LA
• Article: THE JOURNAL OF PATHOLOGY: CLINICAL RESEARCH. 2017;3(1):38-43

  High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer

  Paulsson J; Ryden L; Strell C; Frings O; Tobin NP; Fornander T; Bergh J; Landberg G; Stal O; Ostman A
• Article: CANCER RESEARCH. 2016;76(11):3166-3178

  Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages

  Wallerius M; Wallmann T; Bartish M; Ostling J; Mezheyeuski A; Tobin NP; Nygren E; Pangigadde P; Pellegrini P; Squadrito ML; Ponten F; Hartman J; Bergh J; DeMilito A; De Palma M; Ostman A; Andersson J; Rolny C
• Article: CLINICAL CANCER RESEARCH. 2016;22(10):2417-2426

  An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors

  Tobin NP; Wennmalm K; Lindstrom LS; Foukakis T; He L; Genove G; Ostman A; Landberg G; Betsholtz C; Bergh J
• Article: MODERN PATHOLOGY. 2016;29(4):318-329

  Digital image analysis outperforms manual biomarker assessment in breast cancer

  Stalhammar G; Martinez NF; Lippert M; Tobin NP; Molholm I; Kis L; Rosin G; Rantalainen M; Pedersen L; Bergh J; Grunkin M; Hartman J
• Article: MOLECULAR ONCOLOGY. 2016;10(4):517-525

  Intrinsic subtypes and genomic signatures of primary breast cancer and prognosis after systemic relapse

  Falato C; Tobin NP; Lorent J; Lindstrom LS; Bergh J; Foukakis T
• Corrigendum: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3):djv434

  Erratum.
• Review: JOURNAL OF INTERNAL MEDICINE. 2015;278(6):545-570

  The importance of molecular markers for diagnosis and selection of targeted treatments in patients with cancer

  Tobin NP; Foukakis T; De Petris L; Bergh J
• Article: ONCOTARGET. 2015;6(32):33306-33318

  Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications

  Kimbung S; Kovacs A; Danielsson A; Bendahl P-O; Lovgren K; Stolt MF; Tobin NP; Lindstrom L; Bergh J; Einbeigi Z; Ferno M; Hatschek T; Hedenfalk I
• Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209

  Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

  Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
• Article: ANNALS OF ONCOLOGY. 2015;26(1):81-88

  Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival

  Tobin NP; Harrell JC; Lövrot J; Egyhazi Brage S; Frostvik Stolt M; Carlsson L; Einbeigi Z; Linderholm B; Loman N; Malmberg M; Walz T; Fernö M; Perou CM; Bergh J; Hatschek T; Lindström LS
• Corrigendum: MOLECULAR ONCOLOGY. 2014;8(6):1159

  Multi-level gene expression signatures, but not binary, outperform Ki67 for the long term prognostication of breast cancer patients (vol 8, pg 741, 2014)

  Tobin NP; Lindstrom LS; Carlson JW; Bjohle J; Bergh J; Wennmalm K
• Article: MOLECULAR ONCOLOGY. 2014;8(3):741-752

  Multi-level gene expression signatures, but not binary, outperform Ki67 for the long term prognostication of breast cancer patients

  Tobin NP; Lindstrom LS; Carlson JW; Bjohle J; Bergh J; Wennmalm K
• Article: BMC CANCER. 2014;14:119

  Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

  Lehn S; Tobin NP; Sims AH; Stal O; Jirstrom K; Axelson H; Landberg G
• Article: BMC CANCER. 2013;13:473

  Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies

  Milosevic J; Klinge J; Borg A-L; Foukakis T; Bergh J; Tobin NP
• Article: AMERICAN JOURNAL OF PATHOLOGY. 2013;182(6):2037-2047

  Prognostic Significance in Breast Cancer of a Gene Signature Capturing Stromal PDGF Signaling

  Frings O; Augsten M; Tobin NP; Carlson J; Paulsson J; Pena C; Olsson E; Veerla S; Bergh J; Ostman A; Sonnhammer ELL
• Article: HUMAN PATHOLOGY. 2012;43(11):2053-2061

  Automated image analysis of cyclin D1 protein expression in invasive lobular breast carcinoma provides independent prognostic information

  Tobin NP; Lundgren KL; Conway C; Anagnostaki L; Costello S; Landberg G
• Article: CURRENT BREAST CANCER REPORTS. 2012;4(3):171-173

  Analysis of Cyclin D1 in Breast Cancer: A Call to Arms.

  Tobin NP; Bergh J
• Article: BMC CANCER. 2011;11:417

  Cyclin D1, Id1 and EMT in breast cancer

  Tobin NP; Sims AH; Lundgren KL; Lehn S; Landberg G
• Article: JOURNAL OF MOLECULAR DIAGNOSTICS. 2011;13(3):340-351

  Stromal Expression of β-Arrestin-1 Predicts Clinical Outcome and Tamoxifen Response in Breast Cancer

  Lundgren K; Tobin NP; Lehn S; Stal O; Ryden L; Jirstrom K; Landberg G
• Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(6):2886-2897

  Down-Regulation of the Oncogene Cyclin D1 Increases Migratory Capacity in Breast Cancer and Is Linked to Unfavorable Prognostic Features

  Lehn S; Tobin NP; Berglund P; Nilsson K; Sims AH; Jirstrom K; Harkonen P; Lamb R; Landberg G
• Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2009;41(11):2287-2294

  Down-regulation of neprilysin (EC3.4.24.11) expression in vascular endothelial cells by laminar shear stress involves NADPH oxidase-dependent ROS production

  Fitzpatrick PA; Guinan AF; Walsh TG; Murphy RP; Killeen MT; Tobin NP; Pierotti AR; Cummins PM
• Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2008;295(4):H1403-H1413

  Helicobacter pylori-induced inhibition of vascular endothelial cell functions:: a role for VacA-dependent nitric oxide reduction

  Tobin NP; Henehan GT; Murphy RP; Atherton JC; Guinan AF; Kerrigan SW; Cox D; Cahill PA; Cummins PM
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Medarbetare och kontakt

Gruppledare

• 

  Nick Tobin

  Adjunkt | Senior Forskare | Docent

  E-postadress nick.tobin@ki.se

Alla medarbetare i gruppen

• Paula Camargo Romera

  Doktorand

  E-postadress paula.camargo.romera@ki.se
• Miguel Castresana Aguirre

  Postdoktor

  E-postadress miguel.castresana.aguirre@ki.se
• 

  Nick Tobin

  Adjunkt | Senior Forskare | Docent

  E-postadress nick.tobin@ki.se