Molekylär och cellulär arbetsfysiologi – Ruas lab

Publikationer

Utvalda publikationer

• Editorial comment: CELL. 2022;185(8):1444-1444.e1

  Regulation and biology of PGC-1α

  Jannig PR; Dumesic PA; Spiegelman BM; Ruas JL
• Article: CELL METABOLISM. 2021;33(11):2215-2230.e8

  Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

  Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Shvaikovskaya D; Zhengye L; Cervenka I; Khan N; Stec M; Oliveira M; Nijssen J; Martinez-Redondo V; Ducommun S; Azzolini M; Lanner JT; Kleiner S; Hedlund E; Ruas JL
• Review: TRENDS IN MOLECULAR MEDICINE. 2021;27(10):946-954

  The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?

  Joisten N; Ruas JL; Braidy N; Guillemin GJ; Zimmer P
• Article: METABOLITES. 2021;11(8):508

  Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans

  Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
• Editorial comment: SCIENCE. 2020;368(6490):470-471

  Exercised cytokines promote endurance

  Correia JC; Ruas JL
• Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:591476

  Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats

  Kelahmetoglu Y; Jannig PR; Cervenka I; Koch LG; Britton SL; Zhou J; Wang H; Robinson MM; Nair KS; Ruas JL
• Article: SKELETAL MUSCLE. 2019;9(1):26

  LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force

  Ferreira DMS; Cheng AJ; Agudelo LZ; Cervenka I; Chaillou T; Correia JC; Porsmyr-Palmertz M; Izadi M; Hansson A; Martinez-Redondo V; Valente-Silva P; Pettersson-Klein AT; Estall JL; Robinson MM; Nair KS; Lanner JT; Ruas JL
• Article: NATURE COMMUNICATIONS. 2019;10(1):2767

  Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

  Agudelo LZ; Ferreira DMS; Dadyar S; Cervenka I; Ketscher L; Izadi M; Liu Z; Furrer R; Handschin C; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Ruas JL
• Article: MOLECULAR METABOLISM. 2018;9:28-42

  Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

  Pettersson-Klein AT; Izadi M; Ferreira DMS; Cervenka I; Correia JC; Martinez-Redondo V; Southern M; Cameron M; Kamenecka T; Agudelo LZ; Porsmyr-Palmertz M; Martens U; Lundgren B; Otrocka M; Jenmalm-Jensen A; Griffin PR; Ruas JL
• Article: CELL METABOLISM. 2018;27(2):378-392.e5

  Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

  Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
• Review: SCIENCE. 2017;357(6349):eaaf9794

  Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health

  Cervenka I; Agudelo LZ; Ruas JL
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184

  Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes

  Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
• Article: MOLECULAR METABOLISM. 2015;4(12):891-902

  Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

  Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
• Review: DIABETOLOGIA. 2015;58(9):1969-1977

  The hitchhiker's guide to PGC-1α isoform structure and biological functions

  Martinez-Redondo V; Pettersson AT; Ruas JL
• Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2015;26(6):305-314

  Intercellular: local and systemic actions of skeletal muscle PGC-1s

  Correia JC; Ferreira DMS; Ruas JL
• Article: CELL. 2014;159(1):33-45

  Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

  Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
• Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(2):E157-E167

  Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

  Sczelecki S; Besse-Patin A; Abboud A; Kleiner S; Laznik-Bogoslavski D; Wrann CD; Ruas JL; Haibe-Kains B; Estall JL

Alla gruppmedlemmars publikationer

• Doctoral thesis: 2025

  Inter-organ communication and metabolic regulators of adipose tissue and skeletal muscle

  Dumont K
• Article: SKELETAL MUSCLE. 2025;15(1):9

  Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1-and autophagic signaling in human type I and type II muscle fibers

  Horwath O; Cornet L; Stroemlind H; Moberg M; Edman S; Soederlund K; Checa A; Ruas JL; Blomstrand E
• Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2025;328(2):E274-E285

  Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolism

  Dumont KD; Jannig PR; Porsmyr-Palmertz M; Ruas JL
• Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167373

  Oxygen-sensitive Regulation of Mitochondrial Mass and its implication in the von Hippel-Lindau Syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Juhlin CC; von Kriegsheim A; Cao Y; Schlisio S
• Article: ACTA DERMATO-VENEREOLOGICA. 2024;104:adv40796

  Risk Factors Associated with Weight Gain during Treatment with Dupilumab among Patients with Moderate to Severe Atopic Dermatitis

  Tayefi M; Svedbom A; Ivert LU; Lundqvist M; Ruas JL; Bradley M; Johansson EK
• Article: NATURE COMMUNICATIONS. 2024;15(1):9826

  The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

  Pham TCP; Raun SH; Havula E; Henriquez-Olguin C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig PR; Andersen NR; Kruse R; Ali MS; Irazoki A; Halling JF; Ringholm S; Needham EJ; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ortenblad N; Hojlund K; Kjaer M; Ruas JL; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2024;224:s9-s10

  Exploring the Connection Between Chronic Inflammation, NR4A3, and Mitochondrial Deficiency in Skeletal muscle

  Alves ES; van Deventer A; Jude B; Shorter E; Smith J; Steinz M; Gustafsson T; Rullman E; von Walden F; Svensson C; Zierath JR; Ruas JL; Lanner J
• Article: AGING CELL. 2024;23(11):e14295

  Senescence detection using reflected light

  Dedic B; Westerberg L; Solis AM; Dumont KD; Ruas JL; Thorell A; Naslund E; Spalding KL
• Preprint: BIORXIV. 2024

  Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers

  Horwath O; Cornet L; Strömlind H; Moberg M; Edman S; Söderlund K; Checa A; Ruas JL; Blomstrand E
• Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10):2007-2015

  Mood, Cognitive Function, and Plasma Kynurenine Metabolites Responses Following Severe Changes in Physical Activity

  Kamandulis S; Lukonaitiene I; Snieckus A; Brazaitis M; Mickevicius M; Cernych M; Ruas J; Schwieler L; Louvrou V; Erhardt S; Westerblad H; Venckunas T
• Journal article: ELIFE. 2024;12

  A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

  Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
• Article: ELIFE. 2024;12:rp92707

  A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

  Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Karppinen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(34):e2319724121

  Zfp697 is an RNA- binding protein that regulates skeletal muscle inflammation and remodeling

  Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Praestholm SM; Dias JM; Dumont KD; Liu Z; Liang Q; Edsgaerd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Teixeira AI; Yeo GW; Ruas JL
• Article: MOLECULAR METABOLISM. 2024;82:101912

  Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition

  Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbuhler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; Haworth SM; Martinez-Redondo V; Liu Z; Carlstrom M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
• Preprint: RESEARCH SQUARE. 2024

  The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

  Sylow L; Pham TCP; Raun S; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen A; Jannig P; Andersen N; Kruse R; Ali M; Halling J; Ringholm S; Needham E; Hansen S; Lemminger A; Schjerling P; Petersen M; de Almeida M; Jensen T; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski J; Nielsen J; Qvortrup K; Pilegaard H; Richter E
• Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2024;103(1):151377

  Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration

  Nunes MJ; Carvalho AN; Sa-Lemos C; Colaco M; Cervenka I; Ciraci V; Santos SG; Ribeiro MM; Castanheira M; Jannig PR; Gama MJ; Castro-Caldas M; Rodrigues CMP; Rodrigues E; Ruas JL
• Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(2):166980

  NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease

  Caria I; Nunes MJ; Ciraci V; Carvalho AN; Ranito C; Santos SG; Gama MJ; Castro-Caldas M; Rodrigues CMP; Ruas JL; Rodrigues E
• Article: NATURE NANOTECHNOLOGY. 2024;19(2):237-245

  Multivalent insulin receptor activation using insulin-DNA origami nanostructures

  Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
• Journal article: NATURE NANOTECHNOLOGY. 2024;19(2)

  Multivalent insulin receptor activation using insulin-DNA origami nanostructures

  Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
• Preprint: BIORXIV. 2023

  The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

  Pham TCP; Raun SH; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig P; Andersen NR; Kruse R; Ali MS; Halling JF; Ringholm S; Needham E; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
• Preprint: BIORXIV. 2023

  A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue

  Wadsworth B; Leiwe M; Minogue E; Cunha P; Engman V; Brombach C; Asvestis C; Sah-Teli S; Marklund E; Koivunen P; Ruas J; Rundqvist H; Lanner J; Johnson R
• Journal article: TOXICOLOGY LETTERS. 2023;384(Front. Cell Dev. Biol. 9 2021):s188-S193

  P16-19: The role of glucose homeostasis and glucocorticoid signalling for the development of relevant hepatic in vitro models for toxicology, drug metabolism and energy metabolism studies

  Rodrigues JS; Faria-Pereira A; Camões SP; Serras AS; Morais VA; Ruas JL; Miranda JP
• Journal article: ENDOCRINOLOGY. 2023;164(10):bqad128

  Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice

  Correia CM; Praestholm SM; Havelund JF; Pedersen FB; Siersbaek MS; Ebbesen MF; Gerhart-Hines Z; Heeren J; Brewer J; Larsen S; Blagoev B; Faergeman NJ; Grontved L
• Preprint: BIORXIV. 2023;BIORXIV

  Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.

  Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Præstholm SM; Dumont K; Liu Z; Liang Q; Edsgärd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Yeo GW; Ruas JL
• Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:839

  SKELETAL MUSCLE PGC1.1 PREVENTS ARTHRITIS-INDUCED CAPILLARY RAREFACTION AND IMPAIRED GLUCOSE UPTAKE

  Jude B; Chibalin A; Ducommun S; Zierath J; Von Walden F; Ruas J; Krook A; Lanner J
• Article: CELL REPORTS. 2023;42(1):112021

  Epiblast-like stem cells established by Wnt/(3-catenin signaling manifest distinct features of formative pluripotency and germline competence

  Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
• Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:S741

  Uncovering a novel potential target in non-alcoholic fatty liver disease

  Praestholm SM; Correia J; Ruas J
• Conference publication: ACTA PHYSIOLOGICA. 2023;239

  Can PGC-1α1 counteract skeletal muscle capillary rarefaction and reduced glucose uptake induced by chronic inflammation?

  Jude B; Tagadirt L; Santos-Alves E; Mader T; Chibalin AV; Ducommun S; Zierath JR; Von Walden F; Krook A; Ruas JL; Lanner JT
• Conference publication: TOXICOLOGY LETTERS. 2023;384:S188

  The role of glucose homeostasis and glucocorticoid signalling for the development of relevant hepatic in vitro models for toxicology, drug metabolism and energy metabolism studies

  Saraiva Rodrigues J; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
• Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2023;79:85

  The Tryptophan-Kynurenine pathway in the control of energy metabolism

  Ruas JL
• Conference publication: ACTA PHYSIOLOGICA. 2023;239

  Control of cell-cell communication during muscle remodeling and regeneration by a novel RNA-binding protein

  Ruas J
• Conference publication: WOUND REPAIR AND REGENERATION. 2023;31:S19

  STEM CELL-DERIVED HEPATOCYTE-LIKE CELLS RECAPITULATE CUES OF INSULIN RESISTANCE PROGRESSION

  Rodrigues JS; Faria-Pereira A; Camoes SP; Serras AS; Jannig PR; Morais VA; Ruas JL; Miranda JP
• Corrigendum: NATURE METABOLISM. 2022;4(10):1421

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Article: CELLS. 2022;11(19):2944

  PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes

  Tuomainen T; Naumenko N; Mutikainen M; Shakirzyanova A; Sczelecki S; Estall JL; Ruas JL; Tavi P
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(9):102328

  Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias

  Schihada H; Klompstra TM; Humphrys LJ; Cervenka I; Dadvar S; Kolb P; Ruas JL; Schulte G
• Article: BMC BIOLOGY. 2022;20(1):169

  Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

  Oehler D; Spychala A; Godecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
• Article: NATURE METABOLISM. 2022;4(6):739-758

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Article: CARDIOVASCULAR RESEARCH. 2022;118(6):1520-1534

  PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice

  Naumenko N; Mutikainen M; Holappa L; Ruas JL; Tuomainen T; Tavi P
• Conference publication: FASEB JOURNAL. 2022;36

  Ruxolitinib Prevents Ventilator Induced Diaphragm Dysfunction

  Addinsall AB; Cacciani N; Akkad H; Moruzzi N; Maestri A; Shevchenko G; Bergquist J; Ruas J; Larsson L
• Editorial comment: CELL. 2022;185(8):1444-1444.e1

  Regulation and biology of PGC-1α

  Jannig PR; Dumesic PA; Spiegelman BM; Ruas JL
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(638):eaba9112

  HIF-1α inhibitor PX-478 preserves pancreatic. cell function in diabetes

  Ilegems E; Bryzgalova G; Correia J; Yesildag B; Berra E; Ruas JL; Pereira TS; Berggren P-O
• Preprint: BIORXIV. 2022

  Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

  Oehler D; Spychala A; Gödecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
• Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022;41(1):64

  Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model.

  Severin F; Urbani A; Varanita T; Bachmann M; Azzolini M; Martini V; Pizzi M; Tos APD; Frezzato F; Mattarei A; Ghia P; Bertilaccio MTS; Gulbins E; Paradisi C; Zoratti M; Semenzato GC; Leanza L; Trentin L; Szabò I
• Conference publication: FEBS OPEN BIO. 2022;12:34

  Novel players in the regulation of muscle mass, strength, and regeneration

  Ruas J
• Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:1043543

  Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signaling

  Rodrigues JS; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
• Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2022;322(1):C49-C62

  Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism

  Jonsson WO; Ponette J; Horwath O; Rydenstam T; Soderlund K; Ekblom B; Azzolini M; Ruas JL; Blomstrand E
• Preprint: SSRN ELECTRONIC JOURNAL. 2022

  Epiblast-Like Stem Cells Established by Wnt/β-Catenin Signaling Manifest Distinct Features of Formative Pluripotency

  Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Petropoulos S; Chen X; Ruas JL; Wu J; Deng Q
• Article: FASEB JOURNAL. 2021;35(12):e22010

  Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force

  Liu Z; Chaillou T; Santos Alves E; Mader T; Jude B; Ferreira DMS; Hynynen H; Cheng AJ; Jonsson WO; Pironti G; Andersson DC; Kenne E; Ruas JL; Tavi P; Lanner JT
• Doctoral thesis: 2021

  The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity

  Dadvar S
• Journal article: CELL REPORTS. 2021;37(5):109938

  Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage

  Praestholm SM; Correia CM; Goitea VE; Siersbaek MS; Jorgensen M; Havelund JF; Pedersen TA; Faergeman NJ; Grontved L
• Article: CELL METABOLISM. 2021;33(11):2215-2230.e8

  Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

  Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Shvaikovskaya D; Zhengye L; Cervenka I; Khan N; Stec M; Oliveira M; Nijssen J; Martinez-Redondo V; Ducommun S; Azzolini M; Lanner JT; Kleiner S; Hedlund E; Ruas JL
• Article: NATURE COMMUNICATIONS. 2021;12(1):5948

  Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism

  Massart J; Sjogren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barres R; O'Gorman DJ; Zierath JR; Krook A
• Review: TRENDS IN MOLECULAR MEDICINE. 2021;27(10):946-954

  The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?

  Joisten N; Ruas JL; Braidy N; Guillemin GJ; Zimmer P
• Corrigendum: REDOX BIOLOGY. 2021;45:102036

  Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family (vol 37, 101705, 2020)

  Peruzzo R; Mattarei A; Azzolini M; Becker-Flegler KA; Romio M; Rigoni G; Carrer A; Biasutto L; Parrasia S; Kadow S; Manag A; Urbani A; Rossa A; Semenzato G; Soriano ME; Trentin L; Ahmad S; Edwards M; Gulbins E; Paradisi C; Zoratti M; Leanza L; Szabo I
• Article: METABOLITES. 2021;11(8):508

  Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans

  Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
• Article: BIOTECHNOLOGY AND BIOENGINEERING. 2021;118(6):2234-2242

  Effects of topological constraints on the alignment and maturation of multinucleated myotubes

  Song K-Y; Correia JC; Ruas JL; Teixeira AI
• Preprint: BIORXIV. 2021

  Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity

  Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Svaikovskaya D; Zhengye L; Cervenka I; Oliveira M; Nijssen J; Martínez-Redondo V; Stec M; Khan N; Lanner JT; Kleiner S; Hedlund E; Ruas JL
• Article: BMC BIOLOGY. 2021;19(1):57

  Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling

  Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fao L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
• Article: SCIENTIFIC REPORTS. 2021;11(1):6453

  High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles

  Moberg M; Apro W; Cervenka I; Ekblom B; van Hall G; Holmberg H-C; Ruas JL; Blomstrand E
• Article: NATURE COMMUNICATIONS. 2021;12(1):1026

  Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

  Wu H; Petitpre C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
• Article: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2021;2021:7658501

  Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene

  La Spina M; Azzolini M; Salmaso A; Parrasia S; Galletta E; Schiavone M; Chrisam M; Mattarei A; Di Benedetto G; Ballabio A; Tiso N; Zoratti M; Biasutto L
• Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3582

  Full-length-transcriptomic analysis in mice and human heart using Single-Molecule Real-time Sequencing (SMRT) identified 15 novel isoforms and a novel promoter region of PGC1-alpha

  Oehler D; Goedecke A; Spychala A; Lai K; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
• Article: REDOX BIOLOGY. 2020;37:101705

  Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family

  Peruzzo R; Mattarei A; Azzolini M; Becker-Flegler KA; Romio M; Rigoni G; Carrer A; Biasutto L; Parrasia S; Kadow S; Manago A; Urbani A; Rossa A; Semenzato G; Soriano ME; Trentin L; Ahmad S; Edwards M; Gulbins E; Paradisi C; Zoratti M; Leanza L; Szabo I
• Article: COMMUNICATIONS BIOLOGY. 2020;3(1):541

  Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes

  Hahn M; van Krieken PP; Nord C; Alanentalo T; Morini F; Xiong Y; Eriksson M; Mayer J; Kostromina E; Ruas JL; Sharpe J; Pereira T; Berggren P-O; Ilegems E; Ahlgren U
• Article: NURSING OPEN. 2020;7(5):1446-1452

  A qualitative study-Patient experience of tactile massage after stroke

  Cronfalk BS; Akesson E; Nygren J; Nystrom A; Strandell A-M; Ruas J; von Euler M
• Article: MOLECULAR METABOLISM. 2020;39:101012

  Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN

  Alves CRR; das Neves W; de Almeida NR; Eichelberger EJ; Jannig PR; Voltarelli VA; Tobias GC; Bechara LRG; Faria DDP; Alves MJN; Hagen L; Sharma A; Slupphaug G; Moreira JBN; Wisloff U; Hirshman MF; Negrao CE; de CGJ; Chammas R; Swoboda KJ; Ruas JL; Goodyear LJ; Brum PC
• Journal article: SCIENTIFIC REPORTS. 2020;10(1):14052

  C57BL/6J substrain differences in response to high-fat diet intervention

  Siersbaek MS; Ditzel N; Hejbol EK; Praestholm SM; Markussen LK; Avolio F; Li L; Lehtonen L; Hansen AK; Schroder HD; Krych L; Mandrup S; Langhorn L; Bollen P; Grontved L
• Editorial comment: SCIENCE. 2020;368(6490):470-471

  Exercised cytokines promote endurance

  Correia JC; Ruas JL
• Journal article: PLOS GENETICS. 2020;16(5):e1008770

  Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone

  Praestholm SM; Siersbaek MS; Nielsen R; Zhu X; Hollenberg A; Cheng S-Y; Grontved L
• Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2020;318(5):C818-C830

  The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain

  Martin KS; Azzolin M; Ruas JL
• Article: MOLECULAR METABOLISM. 2020;34:72-84

  PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

  Leveille M; Besse-Patin A; Jouvet N; Gunes A; Sczelecki S; Jeromson S; Khan NP; Baldwin C; Dumouchel A; Correia JC; Jannig PR; Boulais J; Ruas JL; Estall JL
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986

  Modeling the transport of nuclear proteins along single skeletal muscle cells

  Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
• Journal article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:572981

  Multifaceted Control of GR Signaling and Its Impact on Hepatic Transcriptional Networks and Metabolism

  Praestholm SM; Correia CM; Grontved L
• Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:591476

  Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats

  Kelahmetoglu Y; Jannig PR; Cervenka I; Koch LG; Britton SL; Zhou J; Wang H; Robinson MM; Nair KS; Ruas JL
• Article: REDOX BIOLOGY. 2020;28:101387

  Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status

  Peleli M; Ferreira DMS; Tarnawski L; Haworth SM; Xuechen L; Zhuge Z; Newton PT; Massart J; Chagin AS; Olofsson PS; Ruas JL; Weitzberg E; Lundberg JO; Carlstrom M
• Review: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019;181:111557

  Strategies to target bioactive molecules to subcellular compartments. Focus on natural compounds

  Biasutto L; Mattarei A; La Spina M; Azzolini M; Parrasia S; Szabo I; Zoratti M
• Article: SKELETAL MUSCLE. 2019;9(1):26

  LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force

  Ferreira DMS; Cheng AJ; Agudelo LZ; Cervenka I; Chaillou T; Correia JC; Porsmyr-Palmertz M; Izadi M; Hansson A; Martinez-Redondo V; Valente-Silva P; Pettersson-Klein AT; Estall JL; Robinson MM; Nair KS; Lanner JT; Ruas JL
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(21):E5377-5377

  Browning Effects of a Chronic Pterostilbene Supplementation in Mice Fed a High-Fat Diet

  La Spina M; Galletta E; Azzolini M; Gomez Zorita S; Parrasia S; Salvalaio M; Salmaso A; Biasutto L
• Preprint: BIORXIV. 2019

  PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments

  Léveillé M; Besse-Patin A; Jouvet N; Gunes A; Jeromson S; Khan NP; Sczelecki S; Baldwin C; Dumouchel A; Correia J; Jannig P; Boulais J; Ruas JL; Estall JL
• Article: MOLECULAR METABOLISM. 2019;25:159-167

  Epigenetic regulation of diabetogenic adipose morphology

  Kerr AG; Sinha I; Dadvar S; Arner P; Dahlman I
• Article: NATURE COMMUNICATIONS. 2019;10(1):2767

  Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance

  Agudelo LZ; Ferreira DMS; Dadyar S; Cervenka I; Ketscher L; Izadi M; Liu Z; Furrer R; Handschin C; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Ruas JL
• Article: CELLULAR SIGNALLING. 2019;57:45-57

  Chemical genetic screen identifies Gapex-5/GAPVDI and STBD1 as novel AMPK substrates

  Ducommun S; Deak M; Zeigerer A; Goransson O; Seitz S; Collodet C; Madsen AB; Jensen TE; Viollet B; Foretz M; Gut P; Sumpton D; Sakamoto K
• Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2019;52(2):232-239

  Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study.

  La Spina M; Sansevero G; Biasutto L; Zoratti M; Peruzzo R; Berardi N; Sale A; Azzolini M
• Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13

  Activation of the Unfolded Protein Response in Parkinson's disease

  Carvalho A; Ranito C; Tavares C; Castro-Caldas M; Rodrigues E; Ruas J; Van Horssen J; Gama M
• Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13

  Unanswered role of cholesterol homeostasis in Parkinson’s disease

  Nunes M; Caria I; Carvalho A; Costa D; Castro-Caldas M; Gama M; Rodrigues E; Ruas J
• Conference publication: TOXICOLOGY LETTERS. 2019;314:S288

  Hepatocyte-like cells in microfluidic devices: a new platform for disease modelling, drug screening and toxicology

  Rodrigues JS; Cipriano M; Correia J; Camoes SP; Oliveira N; Castro M; Ruas J; Miranda J
• Article: CARDIOVASCULAR RESEARCH. 2019;115(1):107-118

  Heart specific PGC-1 deletion identifies metabolome of cardiac restricted metabolic heart failure

  Karkkainen O; Tuomainen T; Mutikainen M; Lehtonen M; Ruas JL; Hanhineva K; Tavi P
• Journal article: PLOS BIOLOGY. 2018;16(12):e2006249

  Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

  Kalvisa A; Siersbaek MS; Praestholm SM; Christensen LJL; Nielsen R; Stohr O; Vettorazzi S; Tuckermann J; White M; Mandrup S; Grontved L
• Article: PHYSIOLOGICAL GENOMICS. 2018;50(12):1071-1082

  Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice

  Blackwell TA; Cervenka I; Khatri B; Brown JL; Rosa-Caldwell ME; Lee DE; Perry RAJ; Brown LA; Haynie WS; Wiggs MP; Bottje WG; Washington TA; Kong BC; Ruas JL; Greene NP
• Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(5):519-533

  The weight of nutrients: kynurenine metabolites in obesity and exercise

  Dadvar S; Ferreira DMS; Cervenka I; Ruas JL
• Article: EMBO MOLECULAR MEDICINE. 2018;10(8):e8613

  Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors

  Bayindir-Buchhalter I; Wolff G; Lerch S; Sijmonsma T; Schuster M; Gronych J; Billeter AT; Babaei R; Krunic D; Ketscher L; Spielmann N; de Angelis MH; Ruas JL; Mueller-Stich BP; Heikenwalder M; Lichter P; Herzig S; Vegiopoulos A
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;500(1):51-58

  Mitochondrial potassium channels in cell death

  Checchetto V; Azzolini M; Peruzzo R; Capitanio P; Leanza L
• Journal article: IBJ PLUS. 2018

  Exploring the regulation of frataxin expression by neurotrophic factors in the mouse cerebellum after physical exercise.

  Agró M; Díaz Nido J; Giménez Cassina A; Katsu Jiménez Y; da Silva P; Ruas J
• Article: MOLECULAR METABOLISM. 2018;9:28-42

  Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration

  Pettersson-Klein AT; Izadi M; Ferreira DMS; Cervenka I; Correia JC; Martinez-Redondo V; Southern M; Cameron M; Kamenecka T; Agudelo LZ; Porsmyr-Palmertz M; Martens U; Lundgren B; Otrocka M; Jenmalm-Jensen A; Griffin PR; Ruas JL
• Article: CELL METABOLISM. 2018;27(2):378-392.e5

  Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation

  Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
• Journal article: ANNALS OF RESEARCH IN SPORT AND PHYSICAL ACTIVITY. 2018;(ex2018):79-80

  Effects of exercise training on kynurenines, metabolism, and mental health

  Ruas JL
• Article: MOLECULAR METABOLISM. 2018;7:12-22

  Neurturin is a PGC-1 α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation

  Mills R; Taylor-Weiner H; Correia JC; Agudelo LZ; Allodi I; Kolonelou C; Martinez-Redondo V; Ferreira DMS; Nichterwitz S; Comley LH; Lundin V; Hedlund E; Ruas JL; Teixeira AI
• Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(52):E11323-E11332

  Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

  Hoenes GS; Rakov H; Logan J; Liao X-H; Werbenko E; Pollard AS; Praestholm SM; Siersbaek MS; Rijntjes E; Gassen J; Latteyer S; Engels K; Strucksberg K-H; Kleinbongard P; Zwanziger D; Rozman J; Gailus-Durner V; Fuchs H; de Angelis MH; Klein-Hitpass L; Koehrle J; Armstrong DL; Grontved L; Bassett JHD; Williams GR; Refetoff S; Fuehrer D; Moeller LC
• Journal article: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY. 2017;27(4):7218

  Report and Abstracts of the 14th Meeting of IIM, the Interuniversity Institute of Myology, - Assisi (Italy), October 12-15, 2017

  Gabellini D; Musarò A
• Review: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2017;1403(1):27-37

  Resveratrol derivatives as a pharmacological tool

  Biasutto L; Mattarei A; Azzolini M; La Spina M; Sassi N; Romio M; Paradisi C; Zoratti M
• Review: SCIENCE. 2017;357(6349):eaaf9794

  Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health

  Cervenka I; Agudelo LZ; Ruas JL
• Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2017;135:77-88

  Novel lipid-mimetic prodrugs delivering active compounds to adipose tissue

  Mattarei A; Rossa A; Bombardelli V; Azzolini M; La Spina M; Paradisi C; Zoratti M; Biasutto L
• Article: ONCOTARGET. 2017;8(24):38276-38293

  Tumor-reducing effect of the clinically used drug clofazimine in a SCID mouse model of pancreatic ductal adenocarcinoma

  Zaccagnino A; Manago A; Leanza L; Gontarewitz A; Linder B; Azzolini M; Biasutto L; Zoratti M; Peruzzo R; Legler K; Trauzold A; Kalthoff H; Szabo I
• Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2017;115:149-158

  New natural amino acid-bearing prodrugs boost pterostilbene's oral pharmacokinetic and distribution profile

  Azzolini M; Mattarei A; La Spina M; Fanin M; Chiodarelli G; Romio M; Zoratti M; Paradisi C; Biasutto L
• Article: ARCHIVES OF TOXICOLOGY. 2017;91(6):2469-2489

  The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells

  Cipriano M; Correia JC; Camoes SP; Oliveira NG; Cruz P; Cruz H; Castro M; Ruas JL; Santos JM; Miranda JP
• Article: CANCER CELL. 2017;31(4):516-531.e10

  Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo

  Leanza L; Romio M; Becker KA; Azzolini M; Trentin L; Manago A; Venturini E; Zaccagnino A; Mattarei A; Carraretto L; Urbani A; Kadow S; Biasutto L; Martini V; Severin F; Peruzzo R; Trimarco V; Egberts J-H; Hauser C; Visentin A; Semenzato G; Kalthoff H; Zoratti M; Gulbins E; Paradisi C; Szabo I
• Article: DIABETOLOGIA. 2017;60(2):336-345

  A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.

  Chen Q; Xie B; Zhu S; Rong P; Sheng Y; Ducommun S; Chen L; Quan C; Li M; Sakamoto K; MacKintosh C; Chen S; Wang HY
• Article: CELL REPORTS. 2017;18(3):636-646

  Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance

  Ruby MA; Massart J; Hunerdosse DM; Schonke M; Correia JC; Louie SM; Ruas JL; Naslund E; Nomura DK; Zierath JR
• Article: BIOLOGICAL SIGNALS. 2017;25(1):26-38

  Targeting the Potassium Channel Kv1.3 Kills Glioblastoma Cells.

  Venturini E; Leanza L; Azzolini M; Kadow S; Mattarei A; Weller M; Tabatabai G; Edwards MJ; Zoratti M; Paradisi C; Szabò I; Gulbins E; Becker KA
• Editorial comment: ACTA PHYSIOLOGICA. 2017;219(1):14-16

  Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise

  Jannig PR; Ruas JL
• Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17

  The mitochondrial NDUFA4L2 protein: a novel modulator of skeletal muscle mass and force

  Chaillou T; Hynynen H; Ferreira D; Pironti G; Andersson D; Ruas J; Tavi P; Lanner J
• Book chapter: HORMONES, METABOLISM AND THE BENEFITS OF EXERCISE: RESEARCH AND PERSPECTIVES IN ENDOCRINE INTERACTIONS. 2017;p. 83-91

  Tryptophan-Kynurenine Metabolites in Exercise and Mental Health

  Valente-Silva P; Ruas JL
• Conference publication: ACTA PHYSIOLOGICA. 2017;219:20

  Moderate PGC-1α1 expression induces beneficial E-C coupling phenotype without metabolic remodelling

  Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Hynynen H; Laidinen S; Yla-Herttuala S; Heinaniemi M; Ruas J; Tavi P
• Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(23):7049-7071

  Peroxisome proliferator-activated receptor-γ coactivator 1 α1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling

  Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Laidinen S; Kokki K; Hynynen H; Yla-Herttuala S; Heinaniemi M; Ruas JL; Tavi P
• Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186

  NDUFA4L2-Connecting Metabolic Signals and Mitochondrial Function in Cardiac and Skeletal Muscle

  Chaillou T; Hynynen H; Ferreira D; Pironti G; Kenne E; Andersson DC; Ruas JL; Tavi P; Lanner JT
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1863(10):2515-2530

  The mitochondrial permeability transition pore in AD 2016: An update

  Biasutto L; Azzolini M; Szabo I; Zoratti M
• Article: SCIENTIFIC REPORTS. 2016;6:30928

  Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk

  Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CMP; Bjorkhem I; Ruas JL; Rodrigues E
• Article: SCIENCE TRANSLATIONAL MEDICINE. 2016;8(350):350ra103

  The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

  Salah H; Li M; Cacciani N; Gastaldello S; Ogilvie H; Akkad H; Namuduri AV; Morbidoni V; Artemenko KA; Balogh G; Martinez-Redondo V; Jannig P; Hedstrom Y; Dworkin B; Bergquist J; Ruas J; Vigh L; Salviati L; Larsson L
• Letter: ACTA NEUROPSYCHIATRICA. 2016;28(4):244-245

  Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle

  Zepf FD; Stewart RM; Guillemin GJ; Ruas JL
• Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(15):4371-4388

  Mechano-signalling pathways in an experimental intensive critical illness myopathy model

  Kalamgi RC; Salah H; Gastaldello S; Martinez-Redondo V; Ruas JL; Fury W; Bai Y; Gromada J; Sartori R; Guttridge DC; Sandri M; Larsson L
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184

  Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes

  Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
• Article: CELL METABOLISM. 2016;24(1):118-129

  Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.

  Mottillo EP; Desjardins EM; Crane JD; Smith BK; Green AE; Ducommun S; Henriksen TI; Rebalka IA; Razi A; Sakamoto K; Scheele C; Kemp BE; Hawke TJ; Ortega J; Granneman JG; Steinberg GR
• Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016;310(10):C836-C840

  Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans

  Schlittler M; Goiny M; Agudelo LZ; Venckunas T; Brazaitis M; Skurvydas A; Kamandulis S; Ruas JL; Erhardt S; Westerblad H; Andersson DC
• Article: SKELETAL MUSCLE. 2016;6(1):30

  Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle.

  Sakakibara I; Wurmser M; Dos Santos M; Santolini M; Ducommun S; Davaze R; Guernec A; Sakamoto K; Maire P
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(50):15492-15497

  Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca²⁺ leak after one session of high-intensity interval exercise

  Place N; Ivarsson N; Venckunas T; Neyroudard D; Brazaitis M; Cheng AJ; Ochala J; Kamandulis S; Girard S; Volungevicius G; Pauzas H; Mekideche A; Kayser B; Martinez-Redondo V; Ruas JL; Bruton J; Truffert A; Lanner JT; Skurvydas A; Westerblad H
• Article: MOLECULAR METABOLISM. 2015;4(12):891-902

  Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

  Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
• Article: SCIENTIFIC REPORTS. 2015;5:15216

  Amino Acid Carbamates As Prodrugs Of Resveratrol

  Mattarei A; Azzolini M; La Spina M; Zoratti M; Paradisi C; Biasutto L
• Article: MOLECULAR PHARMACEUTICS. 2015;12(9):3441-3454

  Synthesis and Evaluation as Prodrugs of Hydrophilic Carbamate Ester Analogues of Resveratrol

  Azzolini M; Mattarei A; La Spina M; Marotta E; Zoratti M; Paradisi C; Biasutto L
• Article: MOLECULES. 2015;20(9):16085-16102

  N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol

  Mattarei A; Azzolini M; Zoratti M; Biasutto L; Paradisi C
• Review: DIABETOLOGIA. 2015;58(9):1969-1977

  The hitchhiker's guide to PGC-1α isoform structure and biological functions

  Martinez-Redondo V; Pettersson AT; Ruas JL
• Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2015;26(6):305-314

  Intercellular: local and systemic actions of skeletal muscle PGC-1s

  Correia JC; Ferreira DMS; Ruas JL
• Article: CELLULAR SIGNALLING. 2015;27(5):978-988

  Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: identification of mitochondrial fission factor as a new AMPK substrate.

  Ducommun S; Deak M; Sumpton D; Ford RJ; Núñez Galindo A; Kussmann M; Viollet B; Steinberg GR; Foretz M; Dayon L; Morrice NA; Sakamoto K
• Conference publication: DIABETOLOGIA. 2015;58:S300

  Acute exercise impacts kynurenine metabolism in type 2 diabetic and healthy people

  Mudry JM; Ruas JL; Erhardt S; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
• Corrigendum: CELL. 2015;160(1-2):351

  Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression (vol 159, pg 33, 2014)

  Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson A; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
• Article: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2014;14(10):1332-1342

  Improving the Efficacy of Plant Polyphenols

  Biasutto L; Mattarei A; Sassi N; Azzolini M; Romio M; Paradisi C; Zoratti M
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(44):15756-15761

  G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

  White JP; Wrann CD; Rao RR; Nair SK; Jedrychowski MP; You J-S; Martinez-Redondo V; Gygi SP; Ruas JL; Hornberger TA; Wu Z; Glass DJ; Piao X; Spiegelman BM
• Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2014;58(11):2122-2132

  Pharmacokinetics and tissue distribution of pterostilbene in the rat

  Azzolini M; La Spina M; Mattarei A; Paradisi C; Zoratti M; Biasutto L
• Article: MOLECULES. 2014;19(10):15900-15917

  New Water-Soluble Carbamate Ester Derivatives of Resveratrol

  Mattarei A; Carraro M; Azzolini M; Paradisi C; Zoratti M; Biasutto L
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1837(10):1781-1789

  Cytotoxicity of mitochondria-targeted resveratrol derivatives: Interactions with respiratory chain complexes and ATP synthase

  Sassi N; Mattarei A; Azzolini M; Szabo' I; Paradisi C; Zoratti M; Biasutto L
• Article: CELL. 2014;159(1):33-45

  Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

  Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
• Article: CELL. 2014;157(6):1279-1291

  Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

  Rao RR; Long JZ; White JP; Svensson KJ; Lou J; Lokurkar I; Jedrychowski MP; Ruas JL; Wrann CD; Lo JC; Camera DM; Lachey J; Gygi S; Seehra J; Hawley JA; Spiegelman BM
• Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(6):E688-E696

  Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.

  Ducommun S; Ford RJ; Bultot L; Deak M; Bertrand L; Kemp BE; Steinberg GR; Sakamoto K
• Article: MOLECULAR CANCER. 2014;13:54

  Regulation of CDKN2B expression by interaction of Arnt with Miz-1-a basis for functional integration between the HIF and Myc gene regulatory pathways

  Aesoy R; Gradin K; Aasrud KS; Hoivik EA; Ruas JL; Poellinger L; Bakke M
• Article: CURRENT PHARMACEUTICAL DESIGN. 2014;20(2):172-179

  Mitochondria-targeted Resveratrol Derivatives Act as Cytotoxic Pro-oxidants

  Sassi N; Mattarei A; Azzolini M; Bernardi P; Szabo I; Paradisi C; Zoratti M; Biasutto L
• Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(2):E157-E167

  Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

  Sczelecki S; Besse-Patin A; Abboud A; Kleiner S; Laznik-Bogoslavski D; Wrann CD; Ruas JL; Haibe-Kains B; Estall JL
• Article: MOLECULAR PHARMACEUTICS. 2013;10(7):2781-2792

  Acetal Derivatives as Prodrugs of Resveratrol

  Mattarei A; Azzolini M; Carraro M; Sassi N; Zoratti M; Paradisi C; Biasutto L
• Journal article: FASEB JOURNAL. 2013;27(S1):940.18

  A novel PGC‐1á isoform induced by resistance training regulates skeletal muscle hypertrophy

  White J; Ruas J; Rao R; Kleiner S; Wu J; Spiegelman B
• Article: BIOCHEMICAL JOURNAL. 2013;449(2):479-489

  AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

  Wang HY; Ducommun S; Quan C; Xie B; Li M; Wasserman DH; Sakamoto K; Mackintosh C; Chen S
• Article: CELL. 2012;151(6):1319-1331

  A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy

  Ruas JL; White JP; Rao RR; Kleiner S; Brannan KT; Harrison BC; Greene NP; Wu J; Estall JL; Irving BA; Lanza IR; Rasbach KA; Okutsu M; Nair KS; Yan Z; Leinwand LA; Spiegelman BM
• Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;302(9):E1036-E1043

  Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle.

  Ducommun S; Wang HY; Sakamoto K; MacKintosh C; Chen S
• Article: GENES & DEVELOPMENT. 2011;25(12):1232-1244

  Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinase

  Lustig Y; Ruas JL; Estall JL; Lo JC; Devarakonda S; Laznik D; Choi JH; Ono H; Olsen JV; Spiegelman BM
• Article: CELL METABOLISM. 2011;13(2):160-169

  The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex

  Wu J; Ruas JL; Estall JL; Rasbach KA; Choi JH; Ye L; Bostroem P; Tyra HM; Crawford RW; Campbell KP; Rutkowski DT; Kaufman RJ; Spiegelman BM
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(50):21866-21871

  PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types

  Rasbach KA; Gupta RK; Ruas JL; Wu J; Naseri E; Estall JL; Spiegelman BM
• Article: DEVELOPMENT. 2010;137(20):3489-3499

  Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons

  Chakkalakal JV; Nishimune H; Ruas JL; Spiegelman BM; Sanes JR
• Article: NATURE. 2010;466(7305):451-456

  Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

  Choi JH; Banks AS; Estall JL; Kajimura S; Bostroem P; Laznik D; Ruas JL; Chalmers MJ; Kamenecka TM; Blueher M; Griffin PR; Spiegelman BM
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(4):2601-2609

  Complex Regulation of the Transactivation Function of Hypoxia-inducible Factor-1α by Direct Interaction with Two Distinct Domains of the CREB-binding Protein/p300

  Ruas JL; Berchner-Pfannschmidt U; Malik S; Gradin K; Fandrey J; Roeder RG; Pereira T; Poellinger L
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22510-22515

  PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis

  Estall JL; Ruas JL; Choi CS; Laznik D; Badman M; Maratos-Flier E; Shulman GI; Spiegelman BM
• Article: CANCER BIOMARKERS. 2009;5(6):273-277

  Ethnic variability of HIF-1alpha polymorphisms.

  Ribeiro AL; Correia J; Ribeiro V
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(50):21401-21406

  The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle

  Chinsomboon J; Ruas J; Gupta RK; Thom R; Shoag J; Rowe GC; Sawada N; Raghuram S; Arany Z
• Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009;29(7):E16-E17

  HIF-Independent Regulation of Angiogenesis in Ischemia and Exercise

  Arany ZP; Foo S-Y; Chinsomboon J; Girnun G; Cooper M; Ruas J; Bommi-Reddy A; Rangwala S; Baek KH; Rosenzweig A; Spiegelman B
• Article: GENES & DEVELOPMENT. 2008;22(10):1397-1409

  Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

  Kajimura S; Seale P; Tomaru T; Erdjument-Bromage H; Cooper MP; Ruas JL; Chin S; Tempst P; Lazar MA; Spiegelman BM
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373

  Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

  Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
• Article: NATURE. 2008;451(7181):1008-1012

  HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

  Arany Z; Foo S-Y; Ma Y; Ruas JL; Bommi-Reddy A; Girnun G; Cooper M; Laznik D; Chinsomboon J; Rangwala SM; Baek KH; Rosenzweig A; Spiegelman BM
• Review: CURRENT OPINION IN LIPIDOLOGY. 2007;18(5):508-514

  Modular of vascular gene expression by hypoxia

  Ruas JL; Lendahl U; Poellinger L
• Article: FASEB JOURNAL. 2007;21(8):1821-1830

  Hypoxia inducible factor regulates the cardiac expression and secretion of apelin

  Ronkainen V-P; Ronkainen JJ; Hannninen SL; Leskinen H; Ruas JL; Pereira T; Poellinger L; Vuolteenaho O; Tavi P
• Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641

  Cell-type-specific regulation of degradation of hypoxia-inducible factor 1α:: Role of subcellular compartmentalization

  Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
• Article: DEVELOPMENTAL CELL. 2005;9(5):617-628

  Hypoxia requires Notch signaling to maintain the undifferentiated cell state

  Gustafsson MV; Zheng XW; Pereira T; Gradin K; Jin SB; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
• Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2005;16(4-5):514-522

  Hypoxia-dependent activation of HIF into a transcriptional regulator

  Ruas JL; Poellinger L
• Doctoral thesis: 2005

  Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

  Ruas JL
• Article: JOURNAL OF CELL SCIENCE. 2005;118(2):301-311

  Role of CBP in regulating HIF-1-mediated activation of transcription

  Ruas JL; Poellinger L; Pereira T
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):6816-6823

  Identification of residues critical for regulation of protein stability and the transactivation function of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor gene product

  Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(41):38723-38730

  Functional analysis of hypoxia-inducible factor-1α-mediated transactivation -: identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein

  Ruas JL; Poellinger L; Pereira T
• Article: PHARMACOGENETICS AND GENOMICS. 1997;7(4):333-335

  Allele frequency of CYP2C19 in a Portuguese population

  Ruas JL; Lechner MC
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Medarbetare och kontakt

Gruppledare

• 

  Jorge Ruas

  Professor

  Telefon +46852487261

  E-postadress jorge.ruas@ki.se

Alla medarbetare i gruppen

• Michele Azzolini

  Anknuten till Forskning

  E-postadress michele.azzolini@ki.se
• Gerard Baiges-Gaya

  Postdoktorala Studier

  E-postadress gerard.baigesgaya@ki.se
• Igor Cervenka

  Anknuten till Forskning

  E-postadress igor.cervenka@ki.se
• 

  Kyle Dumont

  Anknuten till Forskning

  E-postadress kyle.dumont@ki.se
• 

  Margareta Porsmyr-Palmertz

  Laboratorieansvarig

  E-postadress margareta.porsmyr.palmertz@ki.se
• 

  Stine Marie Præstholm

  Postdoktor

  E-postadress stine.marie.praestholm@ki.se
• 

  Jorge Ruas

  Professor

  Telefon +46852487261

  E-postadress jorge.ruas@ki.se

Besöksadress

Karolinska Institutet, Department of Physiology and Pharmacology, Biomedicum, Solnavägen 9, floor 5, Solna, 171 65

Postadress

Karolinska Institutet, Department of Physiology and Pharmacology, Attn: [Name of recipient], Stockholm, 17171, Sweden