Gonçalo Castelo-Brancos grupp

Vår forskargrupp är intresserad av de molekylära mekanismer som definierar den epigenetiska tillstånd av oligodendrocyter. Vi är särskilt fokuserade på hur samspelet mellan transkriptionsfaktorer, icke -kodande RNA och kromatin modifierande enzymer bidrar till övergången mellan epigenetiska tillstånd i oligodendrocyter, och kunde på så sätt leda till terapier för sjukdomar som multipel skleros .

En del av Institutionen för medicinsk biokemi och biofysik

Publikationer
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Publikationer

Utvalda publikationer

Article: CELL. 2024;187(8):1990-2009.e19
Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology
Kukanja P; Langseth CM; Rodriguez-Kirby LAR; Agirre E; Zheng C; Raman A; Yokota C; Avenel C; Tiklova K; Guerreiro-Cacais AO; Olsson T; Hilscher MM; Nilsson M; Castelo-Branco G
Article: NATURE BIOTECHNOLOGY. 2023;41(6):794-805
Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag
Bartosovic M; Castelo-Branco G
Article: NATURE. 2023;616(7955):113-122
Spatial epigenome-transcriptome co-profiling of mammalian tissues
Zhang D; Deng Y; Kukanja P; Agirre E; Bartosovic M; Dong M; Ma C; Ma S; Su G; Bao S; Liu Y; Xiao Y; Rosoklija GB; Dwork AJ; Mann JJ; Leong KW; Boldrini M; Wang L; Haeussler M; Raphael BJ; Kluger Y; Castelo-Branco G; Fan R
Article: NATURE. 2022;609(7926):375-383
Spatial profiling of chromatin accessibility in mouse and human tissues
Deng Y; Bartosovic M; Ma S; Zhang D; Kukanja P; Xiao Y; Su G; Liu Y; Qin X; Rosoklija GB; Dwork AJ; Mann JJ; Xu ML; Halene S; Craft JE; Leong KW; Boldrini M; Castelo-Branco G; Fan R
Article: NEURON. 2022;110(7):1193-1210.e13
Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility
Meijer M; Agirre E; Kabbe M; van Tuijn CA; Heskol A; Zheng C; Falcao AM; Bartosovic M; Kirby L; Calini D; Johnson MR; Corces MR; Montine TJ; Chen X; Chang HY; Malhotra D; Castelo-Branco G
Article: SCIENCE. 2022;375(6581):681-686
Spatial-CUT&Tag: Spatially resolved chromatin modification profiling at the cellular level
Deng Y; Bartosovic M; Kukanja P; Zhang D; Liu Y; Su G; Enninful A; Bai Z; Castelo-Branco G; Fan R
Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;116:45-52
Crossing boundaries: Interplay between the immune system and oligodendrocyte lineage cells
Kirby L; Castelo-Branco G
Article: NATURE BIOTECHNOLOGY. 2021;39(7):825-835
Single-cell CUT&Tag profiles histone modifications and transcription factors in complex tissues
Bartosovic M; Kabbe M; Castelo-Branco G
Article: NATURE COMMUNICATIONS. 2020;11(1):5860
Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury
Floriddia EM; Lourenco T; Zhang S; van Bruggen D; Hilscher MM; Kukanja P; dos Santos JPG; Altinkok M; Yokota C; Llorens-Bobadilla E; Mulinyawe SB; Graos M; Sun LO; Frisen J; Nilsson M; Castelo-Branco G
Article: NATURE. 2019;566(7745):543-547
Altered human oligodendrocyte heterogeneity in multiple sclerosis
Jakel S; Agirre E; Falcao AM; Van Bruggen D; Lee KW; Knuesel I; Malhotra D; Ffrench-Constant C; Williams A; Castelo-Branco G
Article: NATURE MEDICINE. 2018;24(12):1837-1844
Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis
Falcao AM; van Bruggen D; Marques S; Meijer M; Jakel S; Agirre E; Samudyata; Floriddia EM; Vanichkina DP; Ffrench-Constant C; Williams A; Guerreiro-Cacais AO; Castelo-Branco G
Article: DEVELOPMENTAL CELL. 2018;46(4):504-517.e7
Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development
Marques S; van Bruggen D; Vanichkina DP; Floriddia EM; Munguba H; Varemo L; Giacomello S; Falcao AM; Meijer M; Bjorklund AK; Hjerling-Leffler J; Taft RJ; Castelo-Branco G
Article: SCIENCE. 2016;352(6291):1326-1329
Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system
Marques S; Zeisel A; Codeluppi S; van Bruggen D; Falcao AM; Xiao L; Li H; Haring M; Hochgerner H; Romanov RA; Gyllborg D; Munoz-Manchado AB; La Manno G; Lonnerberg P; Floriddia EM; Rezayee F; Ernfors P; Arenas E; Hjerling-Leffler J; Harkany T; Richardson WD; Linnarsson S; Castelo-Branco G