Inflammatoriska responser kopplade till autoimmunitet och cancer – Mikael Karlssons grupp

Publikationer

Utvalda publikationer

• Article: BLOOD ADVANCES. 2024;8(8):1981-1990

  In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function

  Estupinan HY; Bouderlique T; He C; Berglof A; Cappelleri A; Frengen N; Zain R; Karlsson MCI; Mansson R; Smith CIE
• Letter: CELLULAR & MOLECULAR IMMUNOLOGY. 2024;21(1):91-94

  Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress

  Pei S; Sjolund J; Pan Y; Pietras K; Karlsson MCI
• Review: JOURNAL OF CLINICAL MEDICINE. 2023;12(19):6268

  B Cell Tolerance and Targeted Therapies in SLE

  Parodis I; Long X; Karlsson MCI; Huang X
• Article: ELIFE. 2023;12:e86454

  The role of B cells in immune cell activation in polycystic ovary syndrome

  Ascani A; Torstensson S; Risal S; Lu H; Eriksson G; Li C; Teschl S; Menezes J; Sandor K; Ohlsson C; Svensson CI; Karlsson MCI; Stradner MH; Obermayer-Pietsch B; Stener-Victorin E
• Article: CANCER RESEARCH. 2023;83(10):1628-1645

  FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner

  He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernandez-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Bjornstedt M; Lohr MJ; Karlsson MCI; Heuchel R; Sarhan D
• Article: CANCER IMMUNOLOGY RESEARCH. 2023;11(2):217-227

  Antigen-Loaded Extracellular Vesicles Induce Responsiveness to Anti-PD-1 and Anti-PD-L1 Treatment in a Checkpoint Refractory Melanoma Model

  Veerman RE; Akpinar GG; Offens A; Steiner L; Larssen P; Lundqvist A; Karlsson MCI; Gabrielsson S
• Article: ISCIENCE. 2022;25(11):105317

  Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer

  Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
• Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088

  The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy

  Ingelshed K; Spiegelberg D; Kannan P; Pavenius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
• Article: SCIENTIFIC REPORTS. 2022;12(1):12931

  Deficiency of mature B cells does not alter the atherogenic response to castration in male mice

  Wilhelmson AS; Johansson I; Fogelstrand L; Fagman JB; Arnal J-F; Karlsson MCI; Tivesten A
• Article: AUTOPHAGY. 2022;18(1):204-222

  LRRK2 is required for CD38-mediated NAADP-Ca²⁺ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells

  Nabar NR; Heijjer CN; Shi C-S; Hwang I-Y; Ganesan S; Karlsson MCI; Kehrl JH
• Article: NATURE COMMUNICATIONS. 2021;12(1):4127

  Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

  van Hooren L; Vaccaro A; Ramachandran M; Vazaios K; Libard S; van de Walle T; Georganaki M; Huang H; Pietilae I; Lau J; Ulvmar MH; Karlsson MCI; Zetterling M; Mangsbo SM; Jakola AS; Bontell TO; Smits A; Essand M; Dimberg A
• Article: JOURNAL OF IMMUNOLOGY. 2019;203(4):825-834

  Allogenicity Boosts Extracellular Vesicle-Induced Antigen-Specific Immunity and Mediates Tumor Protection and Long-Term Memory In Vivo

  Larssen P; Veerman RE; Akpinar GG; Hiltbrunner S; Karlsson MCI; Gabrielsson S
• Article: NATURE COMMUNICATIONS. 2019;10(1):2870

  Actomyosin-driven force patterning controls endocytosis at the immune synapse

  Kumari A; Pineau J; Saez PJ; Maurin M; Lankar D; San Roman M; Hennig K; Boura VF; Voituriez R; Karlsson MCI; Balland M; Dumenil A-ML; Pierobon P
• Article: JOURNAL OF IMMUNOLOGY. 2019;202(5):1510-1520

  Gα_i2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination

  Vural A; Nabar NR; Hwang I-Y; Sohn S; Park C; Karlsson MCI; Blumer JB; Kehrl JH
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(3):443-453

  Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses

  Tripathi P; Sedimbi SK; Singh AK; Lofboml L; Issazadeh-Navikas S; Weiss S; Foerster I; Karlsson MCI; Yrlid U; Kadri N; Cardell SL
• Article: EMBO JOURNAL. 2019;38(2):e100010-19

  Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells

  Boenelt P; Woehner M; Minnich M; Tagoh H; Fischer M; Jaritz M; Kavirayani A; Garimella M; Karlsson MCI; Busslinger M
• Article: FRONTIERS IN IMMUNOLOGY. 2019;9:3033

  Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

  Lloyd KA; Wigerblad G; Sahlstrom P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stalesen R; Ossipova E; Lundqvist C; Ekwall O; Ronnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
• Article: CIRCULATION. 2018;138(22):2513-2526

  Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice

  Gistera A; Klement ML; Polyzos KA; Mailer RKW; Duhlin A; Karlsson MCI; Ketelhuth DFJ; Hansson GK
• Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):e145-e158

  Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis

  Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gistera A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
• Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818

  A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia

  Chen X; Gustafsson S; Whitington T; Borne Y; Lorentzen E; Sun J; Almgren P; Su J; Karlsson R; Song J; Lu Y; Zhan Y; Hagg S; Svensson P; Smedby KE; Slager SL; Ingelsson E; Lindgren CM; Morris AP; Melander O; Karlsson T; de Faire U; Caidahl K; Engstrom G; Lind L; Karlsson MCI; Pedersen NL; Frostegard J; Magnusson PKE
• Article: JOURNAL OF IMMUNOLOGY. 2018;200(2):775-787

  Altered Marginal Zone B Cell Selection in the Absence of IκBNS

  Adori M; Pedersen GK; Adori C; Erikson E; Khoenkhoen S; Stark JM; Choi JH; Dosenovic P; Karlsson MCI; Beutler B; Hedestam GBK
• Article: JOURNAL OF INFECTIOUS DISEASES. 2017;216(10):1308-1317

  A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense

  Svedin E; Utorova R; Huhn MH; Larsson PG; Stone VM; Garimella M; Lind K; Hagglof T; Pincikova T; Laitinen OH; McInerney GM; Scholte B; Hjelte L; Karlsson MCI; Flodstrom-Tullberg M
• Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2017;15(1):152

  The clinical importance of tumour-infiltrating macrophages and dendritic cells in periampullary adenocarcinoma differs by morphological subtype

  Lundgren S; Karnevi E; Elebro J; Nodin B; Karlsson MCI; Eberhard J; Leandersson K; Jirstrom K
• Article: MOLECULAR ONCOLOGY. 2017;11(7):781-791

  Epithelial-mesenchymal transition in cancer metastasis through the lymphatic system

  Karlsson MC; Gonzalez SF; Welin J; Fuxe J
• Article: FRONTIERS IN IMMUNOLOGY. 2017;8:738

  Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback

  Forsell MNE; Kvastad L; Sedimbi SK; Andersson J; Karlsson MCI
• Article: NATURE IMMUNOLOGY. 2016;17(12):1407-1414

  Neutrophils license iNKT cells to regulate self reactive mouse B cell responses

  Hagglof T; Sedimbi SK; Yates JL; Parsa R; Salas BH; Harris RA; Leadbetter EA; Karlsson MCI
• Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2618-2626

  Selective Memory to Apoptotic Cell-Derived Self-Antigens with Implications for Systemic Lupus Erythematosus Development

  Duhlin A; Chen Y; Wermeling F; Sedimbi SK; Lindh E; Shinde R; Halaby MJ; Kaiser Y; Winqvist O; McGaha TL; Karlsson MCI
• Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(4):781-789

  Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions

  Smith LE; Olszewski MA; Georgoudaki A-M; Wagner AK; Hagglof T; Karlsson MCI; Dominguez-Villar M; Garcia-Cozar F; Mueller S; Ravens I; Bernhardt G; Chambers BJ
• Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2063-2068

  Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21

  Prokopec KE; Georgoudaki A-M; Sohn S; Wermeling F; Gronlund H; Lindh E; Carroll MC; Karlsson MCI
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2016;213(8):1537-1553

  BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis

  Parsa R; Lund H; Georgoudaki A-M; Zhang X-M; Guerreiro-Cacais AO; Grommisch D; Warnecke A; Croxford AL; Jagodic M; Becher B; Karlsson MCI; Harris RA
• Article: NATURE COMMUNICATIONS. 2016;7:12175

  Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

  Baptista MAP; Keszei M; Oliveira M; Sunahara KKS; Andersson J; Dahlberg CIM; Worth AJ; Lieden A; Kuo I-C; Wallin RPA; Snapper SB; Eidsmo L; Scheynius A; Karlsson MCI; Bouma G; Burns SO; Forsell MNE; Thrasher AJ; Nylen S; Westerberg LS
• Article: ONCOTARGET. 2016;7(25):38707-38717

  Exosomal cancer immunotherapy is independent of MHC molecules on exosomes

  Hiltbrunner S; Larssen P; Eldh M; Martinez-Bravo M-J; Wagner AK; Karlsson MCI; Gabrielsson S
• Article: CELL REPORTS. 2016;15(9):2000-2011

  Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

  Georgoudaki A-M; Prokopec KE; Boura VF; Hellqvist E; Sohn S; Ostling J; Dahan R; Harris RA; Rantalainen M; Klevebring D; Sund M; Brage SE; Fuxe J; Rolny C; Li F; Ravetch JV; Karlsson MCI
• Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):26-43

  Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity

  McGaha TL; Karlsson MCI
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(40):12474-12479

  Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells

  Vomhof-DeKrey EE; Yates J; Hagglof T; Lanthier P; Amiel E; Veerapen N; Besra GS; Karlsson MCI; Leadbetter EA
• Article: JOURNAL OF AUTOIMMUNITY. 2015;62:81-92

  Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies

  Dahlberg CIM; Torres M-L; Petersen SH; Baptista MAP; Keszei M; Volpi S; Grasset EK; Karlsson MCI; Walter JE; Snapper SB; Notarangelo LD; Westerberg LS
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(16):E2030-E2038

  Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response

  Grasset EK; Duhlin A; Agardh HE; Ovchinnikova O; Hagglof T; Forsell MN; Paulsson-Berne G; Hansson GK; Ketelhuth DFJ; Karlsson MCI
• Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2013;70(24):4795-4808

  IL-18 in inflammatory and autoimmune disease

  Sedimbi SK; Hagglof T; Karlsson MCI
• Article: CANCER RESEARCH. 2013;73(13):3865-3876

  Synergistic Induction of Adaptive Antitumor Immunity by Codelivery of Antigen with α-Galactosylceramide on Exosomes

  Gehrmann U; Hiltbrunner S; Georgoudaki A-M; Karlsson MC; Naslund TI; Gabrielsson S
• Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):44-51

  Independent Expansion of Epitope-Specific Plasma Cell Responses upon HIV-1 Envelope Glycoprotein Immunization

  Forsell MNE; Soldemo M; Dosenovic P; Wyatt RT; Karlsson MCI; Hedestam GBK
• Article: JOURNAL OF AUTOIMMUNITY. 2013;42:1-6

  Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1

  Lindh E; Brannstrom J; Jones P; Wermeling F; Hassler S; Betterle C; Garty BZ; Stridsberg M; Herrmann B; Karlsson MCI; Winqvist O
• Article: JOURNAL OF AUTOIMMUNITY. 2013;42:62-70

  AIRE expressing marginal zone dendritic cells balances adaptive immunity and T-follicular helper cell recruitment

  Lindmark E; Chen Y; Georgoudaki A-M; Dudziak D; Lindh E; Adams WC; Lore K; Winqvist O; Chambers BJ; Karlsson MCI
• Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6018-6026

  BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses

  Dosenovic P; Soldemo M; Scholz JL; O'Dell S; Grasset EK; Pelletier N; Karlsson MCI; Mascola JR; Wyatt RT; Cancro MP; Hedestam GBK
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(10):3909-3914

  Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase

  Ravishankar B; Liu H; Shinde R; Chandler P; Baban B; Tanaka M; Munn DH; Mellor AL; Karlsson MCI; McGaha TL
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):E1399-E1407

  The inflammatory cytokine IL-18 induces self-reactive innate antibody responses regulated by natural killer T cells

  Enoksson SL; Grasset EK; Hagglof T; Mattsson N; Kaiser Y; Gabrielsson S; McGaha TL; Scheynius A; Karlsson MCI
• Article: BLOOD. 2011;117(20):5403-5412

  Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen

  McGaha TL; Chen Y; Ravishankar B; van Rooijen N; Karlsson MCI
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(5):943-952

  Invariant NKT cells limit activation of autoreactive CD1d-positive B cells

  Wermeling F; Lind SM; Jordo ED; Cardell SL; Karlsson MCI
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460

  A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses

  Chen Y; Wermeling F; Sundqvist J; Jonsson A-B; Tryggvason K; Pikkarainen T; Karlsson MCI
• Article: JOURNAL OF AUTOIMMUNITY. 2010;34(1):66-72

  AIRE deficiency leads to impaired iNKT cell development

  Lindh E; Rosmaraki E; Berg L; Brauner H; Karlsson MCI; Peltonen L; Hoglund P; Winqvist O
• Article: AUTOIMMUNITY REVIEWS. 2009;9(1):49-52

  An anatomical view on macrophages in tolerance

  Wermeling F; Karlsson MCI; McGaha TL
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2009;39(8):2293-2301

  IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema

  Lind SM; Kuylenstierna C; Moll M; Jordo ED; Winqvist O; Lundeberg L; Karlsson MA; Linder MT; Johansson C; Scheynius A; Sandberg JK; Karlsson MCI
• Article: BLOOD. 2009;113(12):2673-2683

  Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism

  Qazi KR; Gehrmann U; Jordo ED; Karlsson MCI; Gabrielsson S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18466-18471

  AIRE regulates T-cell-independent B-cell responses through BAFF

  Lindh E; Lind SM; Lindmark E; Hassler S; Perheentupa J; Peltonen L; Winqvist O; Karlsson MCI
• Article: JOURNAL OF IMMUNOLOGY. 2008;180(10):6604-6610

  A novel B cell-mediated transport of IgE-immune complexes to the follicle of the spleen

  Hjelm F; Karlsson MCI; Heyman B
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(10):2259-2265

  Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus

  Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JRV; Tryggvason K; Karlsson MCI
• Article: BLOOD. 2006;108(6):1941-1948

  Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma

  Hassler S; Ramsey C; Karlsson MC; Larsson D; Herrmann B; Rozell B; Backheden M; Peltonen L; Kampe O; Winqvist O
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Medarbetare och kontakt

Gruppledare

• 

  Mikael Karlsson

  Professor

  Telefon +46852486175

  E-postadress mikael.karlsson@ki.se

Alla medarbetare i gruppen

• Sandra Kallin

  Doktorand

  E-postadress sandra.kallin@ki.se
• 

  Mikael Karlsson

  Professor

  Telefon +46852486175

  E-postadress mikael.karlsson@ki.se
• Heng Liang

  Postdoktorala Studier

  E-postadress heng.liang@ki.se
• Yueyun Pan

  Doktorand

  E-postadress yueyun.pan@ki.se
• 

  Shengduo Pei

  Doktorand-L

  E-postadress shengduo.pei@ki.se
• 

  Kajsa Westberg

  Doktorand

  E-postadress kajsa.westberg@ki.se