Inflammatoriska responser kopplade till autoimmunitet och cancer – Mikael Karlssons grupp

Publikationer

Utvalda publikationer

• Article: BLOOD ADVANCES. 2024;8(8):1981-1990

  In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function

  Estupinan HY; Bouderlique T; He C; Berglof A; Cappelleri A; Frengen N; Zain R; Karlsson MCI; Mansson R; Smith CIE
• Letter: CELLULAR & MOLECULAR IMMUNOLOGY. 2024;21(1):91-94

  Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress

  Pei S; Sjolund J; Pan Y; Pietras K; Karlsson MCI
• Review: JOURNAL OF CLINICAL MEDICINE. 2023;12(19):6268

  B Cell Tolerance and Targeted Therapies in SLE

  Parodis I; Long X; Karlsson MCI; Huang X
• Article: ELIFE. 2023;12:e86454

  The role of B cells in immune cell activation in polycystic ovary syndrome

  Ascani A; Torstensson S; Risal S; Lu H; Eriksson G; Li C; Teschl S; Menezes J; Sandor K; Ohlsson C; Svensson CI; Karlsson MCI; Stradner MH; Obermayer-Pietsch B; Stener-Victorin E
• Article: CANCER RESEARCH. 2023;83(10):1628-1645

  FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-cell Exhaustion in a Sex-Dependent Manner

  He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernandez-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Bjornstedt M; Lohr MJ; Karlsson MCI; Heuchel R; Sarhan D
• Article: CANCER IMMUNOLOGY RESEARCH. 2023;11(2):217-227

  Antigen-Loaded Extracellular Vesicles Induce Responsiveness to Anti-PD-1 and Anti-PD-L1 Treatment in a Checkpoint Refractory Melanoma Model

  Veerman RE; Akpinar GG; Offens A; Steiner L; Larssen P; Lundqvist A; Karlsson MCI; Gabrielsson S
• Article: ISCIENCE. 2022;25(11):105317

  Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer

  Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
• Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088

  The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy

  Ingelshed K; Spiegelberg D; Kannan P; Pavenius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
• Article: SCIENTIFIC REPORTS. 2022;12(1):12931

  Deficiency of mature B cells does not alter the atherogenic response to castration in male mice

  Wilhelmson AS; Johansson I; Fogelstrand L; Fagman JB; Arnal J-F; Karlsson MCI; Tivesten A
• Article: AUTOPHAGY. 2022;18(1):204-222

  LRRK2 is required for CD38-mediated NAADP-Ca²⁺ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells

  Nabar NR; Heijjer CN; Shi C-S; Hwang I-Y; Ganesan S; Karlsson MCI; Kehrl JH
• Article: NATURE COMMUNICATIONS. 2021;12(1):4127

  Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

  van Hooren L; Vaccaro A; Ramachandran M; Vazaios K; Libard S; van de Walle T; Georganaki M; Huang H; Pietilae I; Lau J; Ulvmar MH; Karlsson MCI; Zetterling M; Mangsbo SM; Jakola AS; Bontell TO; Smits A; Essand M; Dimberg A
• Article: JOURNAL OF IMMUNOLOGY. 2019;203(4):825-834

  Allogenicity Boosts Extracellular Vesicle-Induced Antigen-Specific Immunity and Mediates Tumor Protection and Long-Term Memory In Vivo

  Larssen P; Veerman RE; Akpinar GG; Hiltbrunner S; Karlsson MCI; Gabrielsson S
• Article: NATURE COMMUNICATIONS. 2019;10(1):2870

  Actomyosin-driven force patterning controls endocytosis at the immune synapse

  Kumari A; Pineau J; Saez PJ; Maurin M; Lankar D; San Roman M; Hennig K; Boura VF; Voituriez R; Karlsson MCI; Balland M; Dumenil A-ML; Pierobon P
• Article: JOURNAL OF IMMUNOLOGY. 2019;202(5):1510-1520

  Gα_i2 Signaling Regulates Inflammasome Priming and Cytokine Production by Biasing Macrophage Phenotype Determination

  Vural A; Nabar NR; Hwang I-Y; Sohn S; Park C; Karlsson MCI; Blumer JB; Kehrl JH
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(3):443-453

  Innate and adaptive stimulation of murine diverse NKT cells result in distinct cellular responses

  Tripathi P; Sedimbi SK; Singh AK; Lofboml L; Issazadeh-Navikas S; Weiss S; Foerster I; Karlsson MCI; Yrlid U; Kadri N; Cardell SL
• Article: EMBO JOURNAL. 2019;38(2):e100010

  Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells

  Boenelt P; Woehner M; Minnich M; Tagoh H; Fischer M; Jaritz M; Kavirayani A; Garimella M; Karlsson MCI; Busslinger M
• Article: FRONTIERS IN IMMUNOLOGY. 2019;9:3033

  Differential ACPA Binding to Nuclear Antigens Reveals a PAD-Independent Pathway and a Distinct Subset of Acetylation Cross-Reactive Autoantibodies in Rheumatoid Arthritis

  Lloyd KA; Wigerblad G; Sahlstrom P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stalesen R; Ossipova E; Lundqvist C; Ekwall O; Ronnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
• Article: CIRCULATION. 2018;138(22):2513-2526

  Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice

  Gistera A; Klement ML; Polyzos KA; Mailer RKW; Duhlin A; Karlsson MCI; Ketelhuth DFJ; Hansson GK
• Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):e145-e158

  Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis

  Centa M; Prokopec KE; Garimella MG; Habir K; Hofste L; Stark JM; Dahdah A; Tibbitt CA; Polyzos KA; Gistera A; Johansson DK; Maeda NN; Hansson GK; Ketelhuth DFJ; Coquet JM; Binder CJ; Karlsson MCI; Malin S
• Article: HUMAN MOLECULAR GENETICS. 2018;27(10):1809-1818

  A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia

  Chen X; Gustafsson S; Whitington T; Borne Y; Lorentzen E; Sun J; Almgren P; Su J; Karlsson R; Song J; Lu Y; Zhan Y; Hagg S; Svensson P; Smedby KE; Slager SL; Ingelsson E; Lindgren CM; Morris AP; Melander O; Karlsson T; de Faire U; Caidahl K; Engstrom G; Lind L; Karlsson MCI; Pedersen NL; Frostegard J; Magnusson PKE
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Medarbetare och kontakt

Gruppledare

• 

  Mikael Karlsson

  Professor

  Telefon +46852486175

  E-postadress mikael.karlsson@ki.se

Alla medarbetare i gruppen

• Sandra Kallin

  Doktorand

  E-postadress sandra.kallin@ki.se
• Heng Liang

  Postdoktor

  E-postadress heng.liang@ki.se
• Yueyun Pan

  Doktorand

  E-postadress yueyun.pan@ki.se