Ziegenhain lab

I vår grupp undersöker vi centrala molekylära processer i mänskliga celler, med särskilt fokus på kontrollen av alternativ splicing av transkriberade mRNAs. För detta utvecklar och använder vi nya metoder inom sekvensering av enstaka celler och datorbaserad beräkningsbiologi.

Publikationer

Utvalda publikationer

Article: NATURE BIOTECHNOLOGY. 2022;40(10):1452-1457

Scalable single-cell RNA sequencing from full transcripts with Smart-seq3xpress.

Hagemann-Jensen M; Ziegenhain C; Sandberg R
Article: NATURE METHODS. 2022;19(5):560-566

Molecular spikes: a gold standard for single-cell RNA counting.

Ziegenhain C; Hendriks G-J; Hagemann-Jensen M; Sandberg R
Article: NATURE GENETICS. 2022;54(3):306-317

Transcriptional kinetics and molecular functions of long noncoding RNAs.

Johnsson P; Ziegenhain C; Hartmanis L; Hendriks G-J; Hagemann-Jensen M; Reinius B; Sandberg R
Article: NATURE COMMUNICATIONS. 2021;12(1):6216

BAMboozle removes genetic variation from human sequence data for open data sharing.

Ziegenhain C; Sandberg R
Article: NATURE BIOTECHNOLOGY. 2020;38(6):708-714

Single-cell RNA counting at allele and isoform resolution using Smart-seq3.

Hagemann-Jensen M; Ziegenhain C; Chen P; Ramsköld D; Hendriks G-J; Larsson AJM; Faridani OR; Sandberg R
Article: GIGASCIENCE. 2018;7(6):giy059

zUMIs - A fast and flexible pipeline to process RNA sequencing data with UMIs.

Parekh S; Ziegenhain C; Vieth B; Enard W; Hellmann I
Article: MOLECULAR CELL. 2017;65(4):631-643.e4

Comparative Analysis of Single-Cell RNA Sequencing Methods.

Ziegenhain C; Vieth B; Parekh S; Reinius B; Guillaumet-Adkins A; Smets M; Leonhardt H; Heyn H; Hellmann I; Enard W
Article: CANCER CELL. 2016;30(6):849-862

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia.

Ebinger S; Özdemir EZ; Ziegenhain C; Tiedt S; Castro Alves C; Grunert M; Dworzak M; Lutz C; Turati VA; Enver T; Horny H-P; Sotlar K; Parekh S; Spiekermann K; Hiddemann W; Schepers A; Polzer B; Kirsch S; Hoffmann M; Knapp B; Hasenauer J; Pfeifer H; Panzer-Grümayer R; Enard W; Gires O; Jeremias I

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