Kardiometabol epidemiologi och åldrande – Ida Karlssons forskargrupp

Vi studerar obesitas och kardiometabol hälsa i relation till risk för åldersrelaterade hälsoutfall, med särskilt fokus på förståelse av obesitas som en komplex och heterogen fenotyp med olika orsaker och konsekvenser.

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Vår forskning

Vår forskning fokuserar på kardiometabol epidemiologi och åldrande. Vårt huvudsakliga mål är att dra nytta av heterogeniteten inom obesitas för att förstå varför olika former av övervikt och obesitas har olika samband med risk för åldersrelaterade sjukdomar och hälsoutfall så som demens, hjärt-kärlsjukdom, typ 2 diabetes, och mortalitet. Vårt mål är att bidra till en ökad förståelse av obesitas som en komplex och heterogen fenotyp, med stora individuella skillnader i orsaker och risker för negativa hälsoutfall.

Publikationer

Utvalda publikationer

Alla gruppmedlemmars publikationer

Finansiering

Forskningsbidrag

  • Obesitas och specifika subtyper: Från body mass index mot precisionsmedicin
    Karolinska Institutets Forskningsbidrag
    1 November 2024 - 31 October 2026
  • Overweight as a heterogenous phenotype - Leveraging differences to understand effects on age-related diseases
    The Strategic Research Program in Epidemiology at Karolinska Institutet
    1 November 2023 - 31 December 2023
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2023 - 31 December 2025
    Research problem and specific questions The purpose of this project is to leverage the heterogeneity of overweight to understand how overweight increases the risk of cardiovascular disease, type 2 diabetes, and dementia. We will study adiposity in general and specific adiposity-related traits:Metabolically unhealthy vs healthy adiposityEnvironmentally vs genetically driven adiposityAdiposity measured in midlife vs late-lifeThus, we can study differences in how the adiposity-related traits associate with the age-related diseases, and if these differences are explained by mediating factors or by an acceleration of aging. We will study:Overweight in general, to highlight genes and biological pathways shared between adiposity and the age-related diseases, and seek to identify factors driving the associations.How metabolic biomarkers (e.g. cholesterol levels, inflammatory markers) and other potential mediators (e.g. depressive symptoms) differ among the adiposity-related traits, and if these factors influence the associations with the age-related diseases.If cellular or multisystem aging (telomere length, epigenetic clocks, and frailty) differ among the adiposity-related traits, and influence the association with the age-related diseases.Data and methodAim 1 uses genetic designs and public data. Aim 2-3 applies advanced epidemiological designs to large longitudinal data from the Health and Retirement Study (USA
    n=37,494) and twin cohorts in the IGEMS consortium (Australia, Denmark, Sweden, and USA
    n=89-136).Plan for project realizationThe data are already available, and the realization and costs concern analyses to answer the research questions. The project is led by an interdisciplinary team of researchers in Sweden, China, and the USA. We will recruit a PhD student, who will conduct four studies within the project, and budget for partial financing of a present PhD student, whose work falls within the proposed project.RelevancePreliminary analyses indicate important differences among the adiposity-related traits, and by examining these differences the project will advance our understanding of the heterogeneity of overweight, and of what drives the negative health effects of adiposity in general. It thereby has the potential to identify preventive strategies reducing the risk of several of our most common causes of morbidity and mortality, and promote a healthier aging.
  • Overweight as a heterogeneous phenotype: Leveraging differences among adiposity-related traits to understand effects on age-related disease
    Foundation for Geriatric Diseases at Karolinska Institutet
    1 October 2022 - 30 September 2025
  • Overweight as a heterogeneous phenotype - Leveraging differences to understand effects on age-related diseases
    Karolinska Institutet’s Research Foundation
    1 October 2022 - 30 September 2024
  • Overweight as a heterogeneous phenotype: Leveraging differences among adiposity-related traits to understand effects on age-related disease
    Loo and Hans Osterman Foundation for Medical Research
    1 July 2022 - 30 June 2025
  • Overweight as a heterogeneous phenotype: Leveraging differences in adiposity-related traits to understand effects on age-related disease
    The Strategic Research Program in Epidemiology at Karolinska Institutet
    1 November 2021 - 31 December 2023
  • Council for International Exchange of Scholars
    1 August 2019 - 29 February 2020
  • Swedish Research Council for Health Working Life and Welfare
    1 January 2019 - 31 December 2020

Medarbetare och kontakt

Gruppledare

Alla medarbetare i gruppen

Besöksadress

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, Nobels väg 12A, Stockholm, 171 77, Sweden

Postadress

Karolinska Institutet, Department of Medical Epidemiology and Biostatistics, PO Box 281, Stockholm, 171 77, Sweden

Nyckelord:
Demens Epidemiologi Epidemiologi Fetma Folkhälsovetenskap, global hälsa och socialmedicin Visa alla
Innehållsgranskare:
Ida Karlsson
Gunilla Sonnebring
2025-09-04