Cellplasticitet och behandlingsresistens vid neuroblastom och paragangliom – Schlisio Lab

Publikationer

Utvalda publikationer

• Article: NPJ PRECISION ONCOLOGY. 2025;9(1):324

  Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas

  Bullova P; Cui P; Arceo M; Zhu J; Li W; Plescher M; Poltorachenko V; Stripling K; Santangeli C; Mykhaylechko L; Kastriti ME; Larsson C; Juhlin CC; Mints M; Schlisio S
• Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167373

  Oxygen-sensitive Regulation of Mitochondrial Mass and its implication in the von Hippel-Lindau Syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Juhlin CC; von Kriegsheim A; Cao Y; Schlisio S
• Article: NATURE METABOLISM. 2022;4(6):739-758

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Article: NATURE COMMUNICATIONS. 2021;12(1):5309

  Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

  Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
• Article: NUCLEIC ACIDS RESEARCH. 2021;49(5):2509-2521

  Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors

  Shi Y; Yuan J; Rraklli V; Maxymovitz E; Cipullo M; Liu M; Li S; Westerlund I; Bedoya-Reina OC; Bullova P; Rorbach J; Juhlin CC; Stenman A; Larsson C; Kogner P; O'Sullivan MJ; Schlisio S; Holmberg J
• Letter: CANCER CELL. 2021;39(2):134-135

  Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

  Bedoya-Reina OC; Schlisio S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006

  EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

  Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nister M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WGJ; Schlisio S
• Article: CELL REPORTS. 2018;24(5):1316-1329

  PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

  Rodriguez J; Herrero A; Li S; Rauch N; Quintanilla A; Wynne K; Krstic A; Acosta JC; Taylor C; Schlisio S; von Kriegsheim A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6137-E6146

  Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression

  Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Surova O; Sodersten E; Kogner P; Nyman U; Schlisio S; Holmberg J
• Article: GENES & DEVELOPMENT. 2017;31(10):1036-1053

  Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA

  Fell SM; Li S; Wallis K; Kock A; Surova O; Rraklli V; Hoefig CS; Li W; Mittag J; Henriksson MA; Kenchappa RS; Holmberg J; Kogner P; Schlisio S
• Article: ONCOTARGET. 2016;7(23):34229-34239

  XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis

  Choo Z; Koh RYL; Wallis K; Koh TJW; Kuick CH; Sobrado V; Kenchappa RS; Loh AHP; Soh SY; Schlisio S; Chang KTE; Chen ZX
• Article: DEVELOPMENTAL CELL. 2016;36(2):164-178

  The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis

  Li S; Fell SM; Surova O; Smedler E; Wallis K; Chen ZX; Hellman U; Johnsen JI; Martinsson T; Kenchappa RS; Uhlen P; Kogner P; Schlisio S
• Article: HYPOXIA (AUCKL). 2016;4:15-27

  The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

  Koivunen P; Fell SM; Lu W; Rabinowitz JD; Kung AL; Schlisio S
• Article: CANCER DISCOVERY. 2014;4(4):434-451

  RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma

  Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Hellman U; Sandberg R; Kenchappa RS; Martinson T; Johnsen JI; Kogner P; Schlisio S
• Article: ENDOCRINE-RELATED CANCER. 2010;18(1):73-83

  Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

  Astuti D; Ricketts CJ; Chowdhury R; McDonough MA; Gentle D; Kirby G; Schlisio S; Kenchappa RS; Carter BD; Kaelin WGJ; Ratcliffe PJ; Schofield CJ; Latif F; Maher ER
• Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(10):4104-4112

  Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum

  Schlisio S
• Article: GENES & DEVELOPMENT. 2008;22(7):884-893

  The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

  Schlisio S; Kenchappa RS; Vredeveld LCW; George RE; Stewart R; Greulich H; Shahriari K; Nguyen NV; Pigny P; Dahia PL; Pomeroy SL; Maris JM; Look AT; Meyerson M; Peeper DS; Carter BD; Kaelin WGJ
• Article: NATURE CELL BIOLOGY. 2008;10(3):361-369

  VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

  Young AP; Schlisio S; Minamishima YA; Zhang Q; Li L; Grisanzio C; Signoretti S; Kaelin WGJ
• Article: MOLECULAR CELL. 2007;28(1):15-27

  pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-κB agonist Card9 by CK2

  Yang H; Minamishima YA; Yan Q; Schlisio S; Ebert BL; Zhang X; Zhang L; Kim WY; Olumi AF; Kaelin WGJ
• Article: CANCER CELL. 2005;8(2):155-167

  Neuronal apoptosis linked to EgIN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer

  Lee S; Nakamura E; Yang HF; Wei WY; Linggi MS; Sajan MP; Farese RV; Freeman RS; Carter BD; Kaelin WGJ; Schlisio S

Alla gruppmedlemmars publikationer

• Journal article: MOLECULAR CANCER RESEARCH. 2026;24(8):675-693

  Comparative ASCL1 Interactome Analysis Reveals CDK2-Cyclin A2 as Suppressors of Differentiation in MYCN-Amplified Neuroblastoma.

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Table S4 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Table S3 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Data from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Supplementary Figure S4 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Supplementary Figure S5 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Supplementary Figure S2 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Supplementary Figure S6 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Table S1 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Table S5 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Supplementary Figure S1 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Supplementary Figure S3 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2026

  Table S2 from Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i>-Amplified Neuroblastoma

  Mykhaylechko L; Gomez RL; Woods LM; Papachristou EK; Ramachandran R; Lundie-Brown J; Drummond R; Marcos D; Abou Grealy FMY; Ibragimova S; Ali FR; Carroll J; Philpott A
• Article: CELL REPORTS MEDICINE. 2026;7(4):102715

  Single-cell analysis highlights the significance of malignant cell IFN/MHC-II for immunotherapy response in head and neck squamous cell carcinoma

  Mints M; Sample RA; Parikh AS; Zaretsky JM; Qi Z; Law T; Wang F; Barrett TF; Mullins R; Reeb A; Greenwald AC; Stoller E; Ramadan S; Gerndt S; Oppelt P; Ley J; Thorstad W; Paniello RC; Rich JT; Harbison RA; Zolkind PA; Jackson RS; Pipkorn P; Adkins DR; Uppaluri R; Tirosh I; V. Puram S
• Article: NATURE COMMUNICATIONS. 2026;17(1):2326

  Ribosomal modifications are associated with mesenchymal fate selection in the neural crest lineage

  Poverennaya I; Murtazina A; Li L; Maili L; Sourada L; Montano-Gutierrez LF; Galimullina R; Steinschaden T; Kaiser M; Zikmund T; Goralija A; Gao T; Attina A; Clara O; Bartenhagen C; Erickson A; Gershtein Y; Chen S; Polaskova K; Sterba J; Semasch B; Anderson ER; Prakash V; Vincent T; Arceo M; Kogner P; Schlisio S; Kharchenko PV; David A; Kaiser J; Fischer M; Skoda J; Trainor PA; Chagin AS; Adameyko I
• Article: BLOOD. 2025;146(25):3019-3035

  CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.

  Fleming TJ; Antoszewski M; Lambo S; Gundry MC; Piussi R; Wahlster L; Shah S; Reed FE; Dong KD; Paulo JA; Gygi SP; Mimoso C; Goldman SR; Adelman K; Perry JA; Pikman Y; Stegmaier K; Barrachina MN; Machlus KR; Hovestadt V; Arruda A; Minden MD; Voit RA; Sankaran VG
• Article: CELL DEATH & DISEASE. 2025;17(1):85

  Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors

  Strandgren C; Rondahl V; Oppelt A-S; Ohlin S; Heldin A; Wiman KG
• Article: NPJ PRECISION ONCOLOGY. 2025;9(1):378

  Single-cell transcriptomic analysis of HPV-related multiphenotypic sinonasal carcinoma uncovers MYB-HPV association.

  Wizel A; Spence MDA; Mints M; Britton W; Okolo O; Yu V; Cioffi I; Caruana S; Troob SH; Faquin WC; Lin DT; Tirosh I; Puram SV; Parikh AS; Drier Y
• Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2025;23(1):1304

  Spatial profiling of HPV-stratified head and neck squamous cell carcinoma reveals distinct immune niches and microenvironmental architectures.

  Markovits E; Klymyshyn D; Froumine R; Zong H; Mints M; Mahadevan S; Bloom K; Bates J; Thomas GJ; Diehl L; Puig O; Aggarwal A
• Preprint: BIORXIV. 2025

  Comparative ASCL1 interactome analysis reveals CDK2-Cyclin A2 as suppressors of differentiation in MYCN-amplified neuroblastoma

  Mykhaylechko L; Woods LM; Papachristou EK; Gomez RL; Ramachandran R; Lundie-Brown J; Marcos D; Drummond R; Ali FR; Carroll J; Philpott A
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2025;122(43):e2516922122

  HIF2α negatively regulates MYCN protein levels and promotes a low- risk noradrenergic phenotype in neuroblastoma

  Yuan J; Maitra S; Antoniou E; Zhu J; Li W; Demirel IS; Toskas K; Martinez IL; Ozcimen L; Lindehell H; Muhr J; Stenman J; Kogner P; Bedoya-Reina OC; Schlisio S; Holmberg J
• Article: PLOS BIOLOGY. 2025;23(10):e3003414

  Recurrent circuits encode de novo visual center-surround computations in the mouse superior colliculus

  Cui P; Song K; Mariatos-Metaxas D; Isla AG; Femenia T; Lazaridis I; Meletis K; Kumar A; Kardamakis AA
• Article: NPJ PRECISION ONCOLOGY. 2025;9(1):324

  Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas

  Bullova P; Cui P; Arceo M; Zhu J; Li W; Plescher M; Poltorachenko V; Stripling K; Santangeli C; Mykhaylechko L; Kastriti ME; Larsson C; Juhlin CC; Mints M; Schlisio S
• Preprint: BIORXIV. 2025

  DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cells

  Mantica G; Vedi A; Tuval A; Huerga Encabo H; Hayler D; Krzywon A; Mitchell E; Dunn W; Biezuner T; Bastos H; Sham K; Santoro A; Lee J; Williams N; Danin A; Chapal N; Moskovitz Y; Arruda A; Fiorillo E; Orru V; Marongiu M; McKinney E; Cucca F; Collin M; Minden M; Campbell P; Vassiliou G; Fabre M; Nangalia J; Bonnet D; Shlush L; Laurenti E
• Article: DEVELOPMENTAL CELL. 2025;60(17):2248-2263.e11

  Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity

  Xu Y; Lou D; Chen P; Li G; Usoskin D; Pan J; Li F; Huang S; Hess C; Tang R; Hu X; Yu J; Arceo M; de Krijger RR; Tischler AS; Schlisio S; Ernfors P; Hu Y; Wang J
• Letter: HEMASPHERE. 2025;9(9):e70212

  Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia.

  Koedijk JB; Barneh F; Meesters-Ensing JI; van Tuil M; Sonneveld E; Lambo S; Perzolli A; Schweighart EK; Ferrao Blanco MN; van der Meulen M; Deli A; Haasjes E; Bang Christensen K; de Groot-Kruseman HA; Meshinchi S; Hasle H; Belderbos ME; Luesink M; Goemans BF; Nierkens S; Hehir-Kwa J; Zwaan CM; Heidenreich O
• Journal article: MILITARY MEDICAL RESEARCH. 2025;12(1):46

  Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis

  Jia Z-X; Guo M-T; Li M-M; Liao P; Yan B; Zhang W; Cheng F-Y; Liu Y-R; Zhang Z-H; Wei C; Zhou J; Chen F-L; Lei P; Ge X-T
• Preprint: BIORXIV. 2025;BIORXIV

  Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents.

  Schneider C; Alexe G; Merickel LA; Meyer A; Swift ML; Serafim RB; Basanthakumar AT; Taillon A; Salhotra S; Boniolo F; Lambo S; Rodriguez Y; Häupl B; George RE; Root DE; Oellerich T; Hovestadt V; Chowdhury D; Stegmaier K
• Article: STEM CELLS. 2025;43(8):sxaf026

  DNA hydroxy methylases Tet1 and Tet2 regulate bone aging and bone marrow stromal cell metabolism through the IGF-1/mTOR signaling axis

  Smith N; Cakouros D; Ryan FJ; Lynn DJ; Paton S; Arthur A; Gronthos S
• Preprint: RESEARCH SQUARE. 2025

  Postnatal Sustentacular Cells as Chromaffin Progenitors and Tumor Cells of Origin in VHL-Related Paragangliomas

  Bullova P; Cui P; Arceo M; Zhu J; Li W; Plescher M; Poltorachenko V; Stripling K; Santangeli C; Kastriti ME; Larsson C; Juhlin CC; Mints M; Schlisio S
• Preprint: BIORXIV. 2025

  Palbociclib CDK4/6- and Crizotinib MET/ALK/ROS1-inhibitors Synergize to Enhance Senescence and Immune Recognition in Melanoma Cells Independently of BRAF/NRAS Status

  Zhang F; Boutin L; Das I; Melief J; Singh M; Stantic M; Alzrigat M; Azimi A; Baldran L; Bazzar W; Da Silva Liberio M; Goodwin J; Tuominen R; Höiom V; Jerhammar F; Egyhazi Brage S; Hansson J; Kiessling R; Selivanova G; Wiman K; Wilhelm M; Larsson L-G
• Article: NATURE CANCER. 2025;6(6):1088-1101

  The Curated Cancer Cell Atlas provides a comprehensive characterization of tumors at single-cell resolution

  Tyler M; Gavish A; Barbolin C; Tschernichovsky R; Hoefflin R; Mints M; Puram SV; Tirosh I
• Review: AMERICAN SOCIETY OF CLINICAL ONCOLOGY EDUCATIONAL BOOK / ASCO. AMERICAN SOCIETY OF CLINICAL ONCOLOGY. MEETING. 2025;45(3):e473616

  Capturing Unicorns: Targeting Cancers With TP53 Mutations, RAS Alterations Beyond G12C, and MTAP Loss-No Target Is Out of the Realm of Possibility.

  Shah PA; Wiman KG; Cichowski K; Rodon Ahnert J
• Article: NATURE CANCER. 2025;6(6):1035-1055

  Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions.

  Beck A; Gabler-Pamer L; Alencastro Veiga Cruzeiro G; Lambo S; Englinger B; Shaw ML; Hack OA; Liu I; Haase RD; de Biagi CAO; Baumgartner A; Nascimento Silva AD; Klenner M; Freidel PS; Herms J; von Baumgarten L; Tonn JC; Thon N; Bruckner K; Madlener S; Mayr L; Senfter D; Peyrl A; Slavc I; Lötsch D; Dorfer C; Geyregger R; Amberg N; Haberler C; Mack N; Schwalm B; Pfister SM; Korshunov A; Baird LC; Yang E; Chi SN; Alexandrescu S; Gojo J; Kool M; Hovestadt V; Filbin MG
• Preprint: BIORXIV. 2025

  Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia

  Koedijk JB; Barneh F; Meesters-Ensing JE; van Tuil M; Sonneveld E; Lambo S; Perzolli A; Schweighart EK; Blanco MNF; van der Meulen M; Deli A; Haasjes E; Christensen KB; de Groot-Kruseman HA; Meshinchi S; Hasle H; Belderbos ME; Luesink M; Goemans BF; Nierkens S; Hehir-Kwa J; Zwaan CM; Heidenreich O
• Article: PLOS PATHOGENS. 2025;21(5):e1013112

  A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion

  Yu M; Lin A; Baharom F; Li S; Legendre M; Coves-Datson E; Sohlberg E; Schlisio S; Lore K; Markovitz DM; Smed-Soerensen A
• Preprint: BIORXIV. 2025

  Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors

  Strandgren C; Rondahl V; Oppelt A-S; Öhlin S; Heldin A; Wiman KG
• Preprint: BIORXIV. 2024;BIORXIV

  CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias.

  Fleming TJ; Antoszewski M; Lambo S; Gundry MC; Piussi R; Wahlster L; Shah S; Reed FE; Dong KD; Paulo JA; Gygi SP; Mimoso C; Goldman SR; Adelman K; Perry JA; Pikman Y; Stegmaier K; Barrachina MN; Machlus KR; Hovestadt V; Arruda A; Minden MD; Voit RA; Sankaran VG
• Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167373

  Oxygen-sensitive Regulation of Mitochondrial Mass and its implication in the von Hippel-Lindau Syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Juhlin CC; von Kriegsheim A; Cao Y; Schlisio S
• Preprint: BIORXIV. 2024

  HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma

  Yuan J; Maitra S; Antoniou E; Zhu J; Li W; Demirel IS; Toskas K; Martinez IL; Ozcimen L; Lindehell H; Kogner P; Bedoya-Reina O; Schlisio S; Holmberg J
• Article: CELL REPORTS. 2024;43(10):114784

  Proteome-wide CETSA reveals diverse apoptosisinducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery

  Ramos AD; Liang YY; Surova O; Bacanu S; Gerault M-A; Mandal T; Ceder S; Langeback A; Osterroos A; Ward GA; Bergh J; Wiman KG; Lehmann S; Prabhu N; Loof S; Nordlund P
• Article: CELLULAR & MOLECULAR BIOLOGY LETTERS. 2024;29(1):127

  A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ

  Wei C; Peng D; Jing B; Wang B; Li Z; Yu R; Zhang S; Cai J; Zhang Z; Zhang J; Han L
• Article: CELL DEATH & DISEASE. 2024;15(8):616

  A novel protein encoded by circCOPA inhibits the malignant phenotype of glioblastoma cells and increases their sensitivity to temozolomide by disrupting the NONO-SFPQ complex

  Peng D; Wei C; Jing B; Yu R; Zhang Z; Han L
• Preprint: BIORXIV. 2024;BIORXIV

  A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion.

  Yu M; Lin A; Baharom F; Li S; Legendre M; Covés-Datson E; Sohlberg E; Schlisio S; Loré K; Markovitz DM; Smed-Sörensen A
• Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2024;129:e10719

  Therapeutic targeting of TP53 nonsense mutations in cancer

  Strandgren C; Wiman KG
• Article: FRONTIERS IN PHARMACOLOGY. 2024;15:1375112

  ecGBMsub: an integrative stacking ensemble model framework based on eccDNA molecular profiling for improving IDH wild-type glioblastoma molecular subtype classification

  Li Z; Wei C; Zhang Z; Han L
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(7):4107

  The Catalytic Activity of Human REV1 on Undamaged and Damaged DNA.

  Stolyarenko AD; Novikova AA; Shilkin ES; Poltorachenko VA; Makarova AV
• Journal article: CANCER LETTERS. 2024;585:216665

  Polo-like kinase 4 promotes tumorigenesis and glucose metabolism in glioma by activating AKT1 signaling

  Wang B; Zhang X; Li Z-S; Wei C; Yu R-Z; Du X-Z; He Y-J; Ren Y; Zhen Y-W; Han L
• Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(3):167041

  TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-κB activation

  Xu J; Wei C; Wang C; Li F; Wang Z; Xiong J; Zhou Y; Li S; Liu X; Yang G; Han L; Zhang J; Zhang S
• Review: NATURE REVIEWS CLINICAL ONCOLOGY. 2024;21(2):106-120

  Pharmacological reactivation of p53 in the era of precision anticancer medicine

  Tuval A; Strandgren C; Heldin A; Palomar-Siles M; Wiman KG
• Article: HELIYON. 2024;10(1):e23831

  Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage

  Mollick T; Darekar S; Dalarun B; Plastino F; Zhang J; Fernandez AP; Alkasalias T; Andre H; Lain S
• Article: RNA BIOLOGY. 2023;20(1):368-383

  Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

  Heldin A; Cancer M; Palomar-Siles M; Ohlin S; Zhang M; Sun-Zhang A; Mariani A; Liu J; Bykov VJN; Wiman KGG
• Article: ONCOIMMUNOLOGY. 2023;12(1):2175517

  CD25^bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression

  Chen Z; Tong L; Neo SY; Li S; Gao J; Schlisio S; Lundqvist A
• Article: CANCER CELL. 2023;41(12):2117-2135.e12

  A longitudinal single-cell atlas of treatment response in pediatric AML.

  Lambo S; Trinh DL; Ries RE; Jin D; Setiadi A; Ng M; Leblanc VG; Loken MR; Brodersen LE; Dai F; Pardo LM; Ma X; Vercauteren SM; Meshinchi S; Marra MA
• Article: PLOS ONE. 2023;18(11):e0292468

  Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene

  Palomar-Siles M; Yurevych V; Bykov VJN; Wiman KG
• Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(20):e169671

  Antioxidants stimulate BACH1-dependent tumor angiogenesis

  Wang T; Dong Y; Huang Z; Zhang G; Zhao Y; Yao H; Hu J; Tueksammel E; Cai H; Liang N; Xu X; Yang X; Schmidt S; Qiao X; Schlisio S; Stromblad S; Qian H; Jiang C; Treuter E; Bergo MO
• Journal article: DEVELOPMENTAL CELL. 2023;58(19):1967-1982.e8

  Palbociclib releases the latent differentiation capacity of neuroblastoma cells

  Ferguson KM; Gillen SL; Chaytor L; Poon E; Marcos D; Gomez RL; Woods LM; Mykhaylechko L; Elfari L; da Costa BM; Jamin Y; Carroll JS; Chesler L; Ali FR; Philpott A
• Article: GENOME MEDICINE. 2023;15(1):67

  Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours.

  Nabbi A; Beck P; Delaidelli A; Oldridge DA; Sudhaman S; Zhu K; Yang SYC; Mulder DT; Bruce JP; Paulson JN; Raman P; Zhu Y; Resnick AC; Sorensen PH; Sill M; Brabetz S; Lambo S; Malkin D; Johann PD; Kool M; Jones DTW; Pfister SM; Jäger N; Pugh TJ
• Article: NATURE. 2023;618(7965):598-606

  Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours

  Gavish A; Mints M; Greenwald AC; Hoefflin R; Simkin D; Tschernichovsky R; Galili Darnell N; Somech E; Barbolin C; Antman T; Kovarsky D; Barrett T; Gonzalez Castro LN; Halder D; Chanoch-Myers R; Laffy J; Mints M; Wider A; Tal R; Spitzer A; Hara T; Raitses-Gurevich M; Stossel C; Golan T; Tirosh A; Suva ML; Puram SV; Tirosh I
• Article: BMC MEDICINE. 2023;21(1):199

  MPC-n (IgG) improves long-term cognitive impairment in the mouse model of repetitive mild traumatic brain injury

  Zhang C; Wei C; Huang X; Hou C; Liu C; Zhang S; Zhao Z; Liu Y; Zhang R; Zhou L; Li Y; Yuan X; Zhang J
• Article: NATURE GENETICS. 2023;55(4):640-650

  Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

  Puram SV; Mints M; Pal A; Qi Z; Reeb A; Gelev K; Barrett TF; Gerndt S; Liu P; Parikh AS; Ramadan S; Law T; Mroz EA; Rocco JW; Adkins D; Thorstad WL; Gay HA; Ding L; Paniello RC; Pipkorn P; Jackson RS; Wang X; Mazul A; Chernock R; Zevallos JP; Silva-Fisher J; Tirosh I
• Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(7):6499

  Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging

  Smith N; Shirazi S; Cakouros D; Gronthos S
• Corrigendum: ONCOGENE. 2023;42(9):709

  Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s (vol 33, pg 4407, 2014)

  Bersani C; Xu L-D; Vilborg A; Lui W-O; Wiman KG
• Article: FRONTIERS IN ONCOLOGY. 2022;12:1055371

  PLK4 initiates crosstalk between cell cycle, cell proliferation and macrophages infiltration in gliomas

  Zhang X; Li Z; Wei C; Luo L; Li S; Zhou J; Liang H; Li Y; Han L
• Journal article: FRONTIERS IN IMMUNOLOGY. 2022;13:1058036

  Polo-like kinase 1 is related with malignant characteristics and inhibits macrophages infiltration in glioma

  Luo L; Zhang X-Y; Zhen Y-W; Guo G-C; Peng D-Z; Wei C; Pei D-L; Yu B; Ji Y-C; Liu X-Z; Han L; Zhang Z-Y
• Corrigendum: CELL DEATH DISCOVERY. 2022;8(1):472

  Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells (vol 15, pg 548, 2022)

  Alkasalias T; Zhang J; Madapura H; Dalarun B; Reina OB; Lewensohn R; Viktorsson K; Salihi A; Darekar S; Lain S
• Article: CELL DEATH & DISEASE. 2022;13(11):997

  Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine

  Palomar-Siles M; Heldin A; Zhang M; Strandgren C; Yurevych V; van Dinter JT; Engels SAG; Hofman DA; Ohlin S; Meineke B; Bykov VJN; van Heesch S; Wiman KG
• Article: CELL DEATH DISCOVERY. 2022;8(1):464

  Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells

  Alkasalias T; Zhang J; Madapura H; Dalarun B; Reina OB; Lewensohn R; Viktorsson K; Salihi A; Darekar S; Lain S
• Article: ISCIENCE. 2022;25(11):105317

  Targeting myeloid suppressive cells revives cytotoxic anti-tumor responses in pancreatic cancer

  Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
• Article: CELL DEATH & DISEASE. 2022;13(11):942

  LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway

  Wei C; Zhang X; Peng D; Zhang X; Guo H; Lu Y; Luo L; Wang B; Li Z; He Y; Du X; Zhang S; Liang H; Li S; Wang S; Han L; Zhang J
• Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6545

  HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection (vol 13, 5093, 2022)

  Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
• Article: HAEMATOLOGICA. 2022;107(11):2548-2561

  Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia

  Tuval A; Brilon Y; Azogy H; Moskovitz Y; Leshkowitz D; Salame TM; Minden MD; Tal P; Rotter V; Oren M; Kaushansky N; Shlush LI
• Corrigendum: NATURE METABOLISM. 2022;4(10):1421

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Article: NATURE COMMUNICATIONS. 2022;13(1):5093

  HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection

  Liu R; Muliadi V; Mou W; Li H; Yuan J; Holmberg J; Chambers BJ; Ullah N; Wurth J; Alzrigat M; Schlisio S; Carow B; Larsson LG; Rottenberg ME
• Corrigendum: CELL DEATH & DISEASE. 2022;13(8):672

  Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells (vol 12, 709, 2021)

  Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
• Doctoral thesis: 2022

  Exploring inter- and intra-heterogeneity in childhood neuroblastoma and pheochromocytoma

  Li W
• Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(8):e886

  Screening of cell-virus, cell-cell, gene-gene crosstalk among animal kingdom at single cell resolution

  Chen D; Ou Z; Zhu J; Wang H; Ding P; Luo L; Ding X; Sun C; Lan T; Sahu SK; Wu W; Yuan Y; Wu W; Qiu J; Zhu Y; Yue Q; Jia Y; Wei Y; Qin Q; Li R; Zhao W; Lv Z; Pu M; Lv B; Yang S; Chang A; Wei X; Chen F; Yang T; Wei Z; Yang F; Zhang P; Guo G; Li Y; Hua Y; Liu H
• Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022;41(1):226

  Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma

  Sainero-Alcolado L; Mushtaq M; Liano-Pons J; Rodriguez-Garcia A; Yuan Y; Liu T; Ruiz-Perez MV; Schlisio S; Bedoya-Reina O; Arsenian-Henriksson M
• Journal article: CELL DEATH DISCOVERY. 2022;8(1):325

  The role of N6-methyladenosine-modified non-coding RNAs in the pathological process of human cancer

  Luo L; Zhen Y; Peng D; Wei C; Zhang X; Liu X; Han L; Zhang Z
• Journal article: BIOMEDICINE & PHARMACOTHERAPY. 2022;151:113150

  CircRNA: An emerging star in the progression of glioma

  Peng D; Luo L; Zhang X; Wei C; Zhang Z; Han L
• Journal article: FRONTIERS IN IMMUNOLOGY. 2022;13:944740

  Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas (vol 13, 849592, 2022)

  Wei C; Wang B; Peng D; Zhang X; Li Z; Luo L; He Y; Liang H; Du X; Li S; Zhang S; Zhang Z; Han L; Zhang J
• Article: NATURE METABOLISM. 2022;4(6):739-758

  Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome

  Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
• Preprint: RESEARCH SQUARE. 2022

  LncRNA HOXA11-AS promotes gliomas malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway

  Wei C; Zhang X; Peng D; Lu Y; Luo L; Wang B; Li Z; He Y; Du X; Zhang S; Liang H; Li S; Wang S; Han L; Zhang J
• Article: FRONTIERS IN IMMUNOLOGY. 2022;13:849592

  Pan-Cancer Analysis Shows That ALKBH5 Is a Potential Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Gliomas

  Wei C; Wang B; Peng D; Zhang X; Li Z; Luo L; He Y; Liang H; Du X; Li S; Zhang S; Zhang Z; Han L; Zhang J
• Preprint: RESEARCH SQUARE. 2022

  Polo-like kinase 1 plays an oncogenic role in pan-cancer based on bioinformatics and biological assays

  Luo L; Zhang X-Y; Zhen Y-W; Liu Z; Peng D-Z; Wei C; Liu X-Z; Han L; Zhang Z-Y
• Article: CELL DEATH & DISEASE. 2022;13(3):214

  Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog

  Zhang Q; Balourdas D-I; Baron B; Senitzki A; Haran TE; Wiman KG; Soussi T; Joerger AC
• Article: NUCLEIC ACIDS RESEARCH. 2022;50(2):867-884

  Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon.

  Fefelova EA; Pleshakova IM; Mikhaleva EA; Pirogov SA; Poltorachenko VA; Abramov YA; Romashin DD; Shatskikh AS; Blokh RS; Gvozdev VA; Klenov MS
• Article: NUCLEIC ACIDS RESEARCH. 2022;50(D1):D934-D942

  VThunter: a database for single-cell screening of virus target cells in the animal kingdom

  Chen D; Tan C; Ding P; Luo L; Zhu J; Jiang X; Ou Z; Ding X; Lan T; Zhu Y; Jia Y; Wei Y; Li R; Qin Q; Sun C; Zhao W; Lv Z; Wang H; Wu W; Yuan Y; Pu M; Li Y; Zhang Y; Chang A; Guo G; Bai Y; Jin X; Liu H
• Journal article: EXPERIMENTAL HEMATOLOGY. 2022;111:s151-s152

  3214 – DNMT3A R882 MUTATION IN HUMAN HAEMATOPOIETIC STEM CELLS ALTERS DIFFERENTIATION TOWARDS NEUTROPHILS AND MONOCYTES

  Vedi A; Hayler D; Biezuner T; Mitchell E; Sham K; Krzywon A; Bastos H; Lee J; Tuval A; Danin A; Chapal N; Santoro A; Moskovitz Y; Minden M; Arruda A; Nangalia J; Campbell P; Shlush L; Laurenti E
• Conference publication: EXPERIMENTAL HEMATOLOGY. 2022;111:S151

  DNMT3A R882 MUTATION IN HUMAN HAEMATOPOIETIC STEM CELLS ALTERS DIFFERENTIATION TOWARDS NEUTROPHILS AND MONOCYTES

  Vedi A; Hayler D; Biezuner T; Mitchell E; Sham K; Krzywon A; Bastos H; Lee J; Tuval A; Danin A; Chapal N; Santoro A; Moskovitz Y; Minden M; Arruda A; Nangalia J; Campbell P; Shlush L; Laurenti E
• Preprint: SSRN ELECTRONIC JOURNAL. 2022

  Targeting Myeloid Suppressive Cells Revives Cytotoxic Anti-Tumor Responses in Pancreatic Cancer

  Sarhan D; Eisinger S; Pelicano C; Fei H; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Önfelt B; Schlisio S; Ravetch JV; Heuchel R; Löhr MJ; Karlsson MCI
• Article: CANCERS. 2021;14(1):77

  Whole-Exome Sequencing of HPV Positive Tonsillar and Base of Tongue Squamous Cell Carcinomas Reveals a Global Mutational Pattern along with Relapse-Specific Somatic Variants

  aehrlund-Richter A; Holzhauser S; Dalianis T; Naesman A; Mints M
• Article: NATURE COMMUNICATIONS. 2021;12(1):7083

  Single cell atlas for 11 non-model mammals, reptiles and birds

  Chen D; Sun J; Zhu J; Ding X; Lan T; Wang X; Wu W; Ou Z; Zhu L; Ding P; Wang H; Luo L; Xiang R; Wang X; Qiu J; Wang S; Li H; Chai C; Liang L; An F; Zhang L; Han L; Zhu Y; Wang F; Yuan Y; Wu W; Sun C; Lu H; Wu J; Sun X; Zhang S; Sahu SK; Liu P; Xia J; Zhang L; Chen H; Fang D; Zeng Y; Wu Y; Cui Z; He Q; Jiang S; Ma X; Feng W; Xu Y; Li F; Liu Z; Chen L; Chen F; Jin X; Qiu W; Wang T; Li Y; Xing X; Yang H; Xu Y; Hua Y; Liu Y; Liu H; Xu X
• Journal article: BLOOD. 2021;138:2162

  DNMT3A R882 Mutation in Human Haematopoietic Stem Cells Alters Differentiation Towards Neutrophils and Monocytes

  Vedi A; Hayler D; Biezuner T; Santoro A; Sham K; Tuval A; Danin A; Moskovitz Y; Shlush LI; Laurenti E
• Article: CANCER CELL INTERNATIONAL. 2021;21(1):566

  Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers

  Peng D; Wei C; Zhang X; Li S; Liang H; Zheng X; Jiang S; Han L
• Article: NATURE COMMUNICATIONS. 2021;12(1):5309

  Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

  Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
• Article: SCIENCE BULLETIN. 2021;66(14):1448-1461

  Single-cell atlas of domestic pig cerebral cortex and hypothalamus

  Zhu J; Chen F; Luo L; Wu W; Dai J; Zhong J; Lin X; Chai C; Ding P; Liang L; Wang S; Ding X; Chen Y; Wang H; Qiu J; Wang F; Sun C; Zeng Y; Fang J; Jiang X; Liu P; Tang G; Qiu X; Zhang X; Ruan Y; Jiang S; Li J; Zhu S; Xu X; Li F; Liu Z; Cao G; Chen D
• Article: CELL DEATH & DISEASE. 2021;12(7):709

  Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells

  Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
• Article: CANCERS. 2021;13(13):3242

  Proteomic Profiling of Tissue Exosomes Indicates Continuous Release of Malignant Exosomes in Urinary Bladder Cancer Patients, Even with Pathologically Undetectable Tumour

  Eldh M; Mints M; Hiltbrunner S; Ladjevardi S; Alamdari F; Johansson M; Jakubczyk T; Veerman RE; Winqvist O; Sherif A; Gabrielsson S
• Preprint: RESEARCH SQUARE. 2021

  Study of MiR-451 in the Treatment of Human Gliomas through Regulating the AMPK Pathway Mediated by Bone Mesenchymal Stem Cells

  Zhen Y; Wei C; Zhang X; Gao P; Peng D; Guo H; Han L; Nan Y; Yan D; Zhong Y
• Preprint: BIORXIV. 2021

  Pseudo-mutant p53 as a targetable phenotype of DNMT3A -mutated pre-leukemia

  Tuval A; Brilon Y; Azogy H; Moshkovitz Y; Biezuner T; Leshkowitz D; Salame T; Minden M; Tal P; Rotter V; Oren M; Kaushansky N; Shlush L
• Article: JOURNAL OF GENETICS AND GENOMICS. 2021;48(5):411-425

  A high-resolution cell atlas of the domestic pig lung and an online platform for exploring lung single-cell data

  Zhang L; Zhu J; Wang H; Xia J; Liu P; Chen F; Jiang H; Miao Q; Wu W; Zhang L; Luo L; Jiang X; Bai Y; Sun C; Chen D; Zhang X
• Article: CELL DEATH AND DIFFERENTIATION. 2021;28(5):1477-1492

  Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

  Doffe F; Carbonnier V; Tissier M; Leroy B; Martins I; Mattsson JSM; Micke P; Pavlova S; Pospisilova S; Smardova J; Joerger AC; Wiman KG; Kroemer G; Soussi T
• Article: JOURNAL OF GENETICS AND GENOMICS. 2021;48(4):277-288

  Single-cell brain atlas of Parkinson's disease mouse model

  Zhong J; Tang G; Zhu J; Wu W; Li G; Lin X; Liang L; Chai C; Zeng Y; Wang F; Luo L; Li J; Chen F; Huang Z; Zhang X; Zhang Y; Liu H; Qiu X; Tang S; Chen D
• Journal article: EXPERIMENTAL NEUROLOGY. 2021;338:113606

  Single- and two- chain tissue type plasminogen activator treatments differentially influence cerebral recovery after stroke

  Anfray A; Brodin C; Drieu A; Potzeha F; Dalarun B; Agin V; Vivien D; Orset C
• Preprint: BIORXIV. 2021

  Single-nuclei transcriptomes from human adrenal gland reveals distinct cellular identities of low and high-risk neuroblastoma tumors

  Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
• Article: NUCLEIC ACIDS RESEARCH. 2021;49(5):2509-2521

  Aberrant splicing in neuroblastoma generates RNA-fusion transcripts and provides vulnerability to spliceosome inhibitors

  Shi Y; Yuan J; Rraklli V; Maxymovitz E; Cipullo M; Liu M; Li S; Westerlund I; Bedoya-Reina OC; Bullova P; Rorbach J; Juhlin CC; Stenman A; Larsson C; Kogner P; O'Sullivan MJ; Schlisio S; Holmberg J
• Review: FRONTIERS IN ONCOLOGY. 2021;11:587554

  Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy

  Zhang X; Wei C; Liang H; Han L
• Article: CANCERS. 2021;13(6):1230

  Single-Cell Deconvolution of Head and Neck Squamous Cell Carcinoma.

  Qi Z; Liu Y; Mints M; Mullins R; Sample R; Law T; Barrett T; Mazul AL; Jackson RS; Kang SY; Pipkorn P; Parikh AS; Tirosh I; Dougherty J; Puram SV
• Article: MOLECULAR BIOLOGY. 2021;55(2):305-311

  [Template Properties of 5-Methyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxycytidine in Reactions with Human Translesion and Reparative DNA Polymerases].

  Shilkin ES; Petrova DV; Poltorachenko VA; Boldinova EO; Zharkov DO; Makarova AV
• Article: CANCER BIOLOGY & MEDICINE. 2021;18(1):139-154

  VEGFR2 inhibition hampers breast cancer cell proliferation via enhanced mitochondrial biogenesis

  Ni H; Guo M; Zhang X; Jiang L; Tan S; Yuan J; Cui HL; Min Y; Zhang J; Schlisio S; Ma C; Liao W; Nister M; Chen C; Li S; Li N
• Letter: CANCER CELL. 2021;39(2):134-135

  Chromaffin Cells with Sympathoblast Signature: Too Similar to Keep Apart?

  Bedoya-Reina OC; Schlisio S
• Article: EMBO MOLECULAR MEDICINE. 2021;13(2):e10852

  A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

  Ceder S; Eriksson SE; Cheteh EH; Dawar S; Corrales Benitez M; Bykov VJN; Fujihara KM; Grandin M; Li X; Ramm S; Behrenbruch C; Simpson KJ; Hollande F; Abrahmsen L; Clemons NJ; Wiman KG
• Article: SCIENTIFIC REPORTS. 2021;11(1):1782

  Tumour inflammation signature and expression of S100A12 and HLA class I improve survival in HPV-negative hypopharyngeal cancer

  Mints M; Landin D; Nasman A; Mirzaie L; Ursu RG; Zupancic M; Marklund L; Dalianis T; Munck-Wikland E; Ramqvist T
• Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(6):e12926

  IL-16 processing in sentinel node regulatory T cells is a factor in bladder cancer immunity

  Krantz D; Mints M; Winerdal M; Riklund K; Rutishauser D; Zubarev R; Zirakhzadeh AA; Alamdari F; Johansson M; Sherif A; Winqvist O
• Article: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK. 2020;42(11):3206-3217

  Immune related proteins and tumor infiltratingCD8+lymphocytes in hypopharyngeal cancer in relation to human papillomavirus (HPV) and clinical outcome

  Landin D; Ahrlund-Richter A; Mirzaie L; Mints M; Nasman A; Kolev A; Marklund L; Dalianis T; Munck-Wikland E; Ramqvist T
• Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(10):2685-2700

  Platelet factor 4 enhances CD4⁺T effector memory cell responses via Akt-PGC1α-TFAM signaling-mediated mitochondrial biogenesis

  Tan S; Li S; Min Y; Gistera A; Moruzzi N; Zhang J; Sun Y; Andersson J; Malmstrom RE; Wang M; Berggren P-O; Schlisio S; Liao W; Ketelhuth DFJ; Ma C; Li N
• Editorial: CANCER COMMUNICATIONS. 2020;40(9):453-455

  Nasopharyngeal carcinoma joins the single-cell party.

  Mints M; Tirosh I
• Review: ACTA NEUROPATHOLOGICA. 2020;140(3):249-266

  ETMR: a tumor entity in its infancy.

  Lambo S; von Hoff K; Korshunov A; Pfister SM; Kool M
• Article: HIP INTERNATIONAL. 2020;30(4):469-473

  Undersizing the Exeter stem in hip hemiarthroplasty increases the risk of periprosthetic fracture.

  Korsnes L; Gottvall A; Buttazzoni C; Mints M
• Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(12):E4299-4299

  CAIX-Mediated Control of LIN28/let-7Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia

  Gibadulinova A; Bullova P; Strnad H; Pohlodek K; Jurkovicova D; Takacova M; Pastorekova S; Svastova E
• Article: CELL DEATH DISCOVERY. 2020;6(1):42

  Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

  Cheteh EH; Sarne V; Ceder S; Bianchi J; Augsten M; Rundqvist H; Egevad L; Ostman A; Wiman KG
• Review: ONCOLOGY REPORTS. 2020;43(6):1737-1754

  Recent advances in unraveling the molecular mechanisms and functions of HOXA11-AS in human cancers and other diseases

  Wei C; Zhao L; Liang H; Zhen Y; Han L
• Article: SCIENTIFIC REPORTS. 2020;10(1):5960

  Urinary Exosomes from Bladder Cancer Patients Show a Residual Cancer Phenotype despite Complete Pathological Downstaging

  Hiltbrunner S; Mints M; Eldh M; Rosenblatt R; Holmstrom B; Alamdari F; Johansson M; Veerman RE; Winqvist O; Sherif A; Gabrielsson S
• Journal article: AGING-US. 2020;12(7):5781-5791

  A novel germline gain-of-function HIF2A mutation in hepatocellular carcinoma with polycytnemia

  Yu J; Shi X; Yang C; Bullova P; Hong CS; Nesvick CL; Dmitriev P; Pacak K; Zhuang Z; Cao H; Li L
• Article: FRONTIERS IN ONCOLOGY. 2020;10:584681

  Potential Importance of Early Focal Radiotherapy Following Gross Total Resection for Long-Term Survival in Children With Embryonal Tumors With Multilayered Rosettes.

  Mayr L; Gojo J; Peyrl A; Azizi AA; Stepien NM; Pletschko T; Czech T; Dorfer C; Lambo S; Dieckmann K; Haberler C; Kool M; Slavc I
• Article: NATURE. 2019;576(7786):274-280

  The molecular landscape of ETMR at diagnosis and relapse.

  Lambo S; Gröbner SN; Rausch T; Waszak SM; Schmidt C; Gorthi A; Romero JC; Mauermann M; Brabetz S; Krausert S; Buchhalter I; Koster J; Zwijnenburg DA; Sill M; Hübner J-M; Mack N; Schwalm B; Ryzhova M; Hovestadt V; Papillon-Cavanagh S; Chan JA; Landgraf P; Ho B; Milde T; Witt O; Ecker J; Sahm F; Sumerauer D; Ellison DW; Orr BA; Darabi A; Haberler C; Figarella-Branger D; Wesseling P; Schittenhelm J; Remke M; Taylor MD; Gil-da-Costa MJ; Łastowska M; Grajkowska W; Hasselblatt M; Hauser P; Pietsch T; Uro-Coste E; Bourdeaut F; Masliah-Planchon J; Rigau V; Alexandrescu S; Wolf S; Li X-N; Schüller U; Snuderl M; Karajannis MA; Giangaspero F; Jabado N; von Deimling A; Jones DTW; Korbel JO; von Hoff K; Lichter P; Huang A; Bishop AJR; Pfister SM; Korshunov A; Kool M
• Preprint: BIORXIV. 2019

  Alternative splicing in neuroblastoma generates RNA-fusion transcripts and is associated with vulnerability to spliceosome inhibitors

  Shi Y; Rraklli V; Maxymovitz E; Li S; Westerlund I; Bedoya-Reina O; Yuan J; Bullova P; Juhlin C; Stenman A; Larsson C; Kogner P; O’Sullivan M; Schlisio S; Holmberg J
• Journal article: ELIFE. 2019;8:e45789

  Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

  Clark DJ; McMillan LE; Tan SL; Bellomo G; Massoue C; Thompson H; Mykhaylechko L; Alibhai D; Ruan X; Singleton KL; Du M; Hedges A; Schwartzberg PL; Verkade P; Murphy RF; Wulfing C
• Corrigendum: CELL DEATH & DISEASE. 2019;10(10):769

  APR-246 reactivates mutant p53 by targeting cysteines 124 and 277 (vol 9, 439, 2018)

  Zhang Q; Bykov VJN; Wiman KG; Zawacka-Pankau J
• Article: CLINICAL GENETICS. 2019;96(3):216-225

  Functional characterization of novel germline TP53 variants in Swedish families

  Kharaziha P; Ceder S; Axell O; Krall M; Fotouhi O; Bohm S; Lain S; Borg A; Larsson C; Wiman KG; Tham E; Bajalica-Lagercrantz S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(34):16997-17006

  EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance

  Li S; Rodriguez J; Li W; Bullova P; Fell SM; Surova O; Westerlund I; Topcic D; Bergsland M; Stenman A; Muhr J; Nister M; Holmberg J; Juhlin CC; Larsson C; von Kriegsheim A; Kaelin WGJ; Schlisio S
• Review: EXPERT OPINION ON BIOLOGICAL THERAPY. 2019;19(8):811-827

  Facing the future: challenges and opportunities in adoptive T cell therapy in cancer.

  Magalhaes I; Carvalho-Queiroz C; Hartana CA; Kaiser A; Lukic A; Mints M; Nilsson O; Grönlund H; Mattsson J; Berglund S
• Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2019;37(15):e14712

  Impact of combined MRP1 inhibition and mutant p53 targeting compound APR-246

  Ceder AS; Eriksson SE; Cheteh EH; Bykov VJN; Abrahmsen L; Wiman KG
• Review: HAEMATOLOGICA. 2019;104(5):872-880

  Evolutionary trajectory of leukemic clones and its clinical implications

  Tuval A; Shlush LI
• Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(4):330-341

  p53 as a hub in cellular redox regulation and therapeutic target in cancer

  Eriksson SE; Ceder S; Bykov VJN; Wiman KG
• Journal article: CANCER LETTERS. 2019;443:91-107

  PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma

  Zhang Z; Wang Z; Huang K; Liu Y; Wei C; Zhou J; Zhang W; Wang Q; Liang H; Zhang A; Wang G; Zhen Y; Han L
• Article: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 2019;45(2):108-118

  Integrated molecular characterization of IDH-mutant glioblastomas.

  Korshunov A; Casalini B; Chavez L; Hielscher T; Sill M; Ryzhova M; Sharma T; Schrimpf D; Stichel D; Capper D; Reuss DE; Sturm D; Absalyamova O; Golanov A; Lambo S; Bewerunge-Hudler M; Lichter P; Herold-Mende C; Wick W; Pfister SM; Kool M; Jones DTW; von Deimling A; Sahm F
• Letter: ACTA NEUROPATHOLOGICA. 2019;137(1):175-177

  ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors.

  Uro-Coste E; Masliah-Planchon J; Siegfried A; Blanluet M; Lambo S; Kool M; Roujeau T; Boetto S; Palenzuela G; Bertozzi A-I; Gambart M; Coupier I; Oliver-Petit I; Golmard L; Julia S; Savagner F; Mohand-Oumoussa B; Tauziede-Espariat A; Delisle M-B; Figarella-Branger D; Bourdeaut F; Rigau V
• Article: TRANSLATIONAL ONCOLOGY. 2018;11(6):1343-1349

  The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells

  Synnott NC; Madden SF; Bykov VJN; Crown J; Wiman KG; Duffy MJ
• Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2018;88(6):e12722

  CCR2 upregulated on peripheral T cells in osteoarthritis but not in bone marrow

  Arkestal K; Mints M; Enocson A; Linton L; Marits P; Glise H; Andersson J; Winqvist O
• Article: CELL CHEMICAL BIOLOGY. 2018;25(10):1219-1230.e3

  Role of Thiol Reactivity for Targeting Mutant p53

  Zhang Q; Bergman J; Wiman KG; Bykov VJN
• Journal article: PLOS BIOLOGY. 2018;16(9):e3000030

  Correction: WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies.

  Mahmoudi S; Henriksson S; Weibrecht I; Smith S; Söderberg O; Strömblad S; Wiman KG; Farnebo M
• Article: SCIENTIFIC REPORTS. 2018;8(1):12671

  Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

  Haffo L; Lu J; Bykov VJN; Martin SS; Ren X; Coppo L; Wiman KG; Holmgren A
• Article: CELL REPORTS. 2018;24(5):1316-1329

  PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

  Rodriguez J; Herrero A; Li S; Rauch N; Quintanilla A; Wynne K; Krstic A; Acosta JC; Taylor C; Schlisio S; von Kriegsheim A
• Journal article: CLINICAL CANCER RESEARCH. 2018;24(14):3423-3432

  Targeting NAD⁺/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma

  Pang Y; Lu Y; Caisova V; Liu Y; Bullova P; Thanh-Truc H; Zhou Y; Yu D; Frysak Z; Hartmann I; Taieb D; Pacak K; Yang C
• Conference publication: CANCER RESEARCH. 2018;78(13):5853

  Targeting NAD⁺/PARP DNA repair pathway as a novel therapeutic approach to SDHB-mutated cluster I pheochromocytoma and paraganglioma

  Pang Y; Lu Y; Caisova V; Liu Y; Bullova P; Thanh-Truc H; Frysak Z; Hartmann I; Taieb D; Pacak K; Yang C
• Corrigendum: NATURE. 2018;559(7714):E10

  Author Correction: The landscape of genomic alterations across childhood cancers.

  Gröbner SN; Worst BC; Weischenfeldt J; Buchhalter I; Kleinheinz K; Rudneva VA; Johann PD; Balasubramanian GP; Segura-Wang M; Brabetz S; Bender S; Hutter B; Sturm D; Pfaff E; Hübschmann D; Zipprich G; Heinold M; Eils J; Lawerenz C; Erkek S; Lambo S; Waszak S; Blattmann C; Borkhardt A; Kuhlen M; Eggert A; Fulda S; Gessler M; Wegert J; Kappler R; Baumhoer D; Burdach S; Kirschner-Schwabe R; Kontny U; Kulozik AE; Lohmann D; Hettmer S; Eckert C; Bielack S; Nathrath M; Niemeyer C; Richter GH; Schulte J; Siebert R; Westermann F; Molenaar JJ; Vassal G; Witt H; Burkhardt B; Kratz CP; Witt O; van Tilburg CM; Kramm CM; Fleischhack G; Dirksen U; Rutkowski S; Frühwald M; von Hoff K; Wolf S; Klingebiel T; Koscielniak E; Landgraf P; Koster J; Resnick AC; Zhang J; Liu Y; Zhou X; Waanders AJ; Zwijnenburg DA; Raman P; Brors B; Weber UD; Northcott PA; Pajtler KW; Kool M; Piro RM; Korbel JO; Schlesner M; Eils R; Jones DTW; Lichter P; Chavez L; Zapatka M; Pfister SM; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project
• Article: ORAL ONCOLOGY. 2018;82:8-16

  MicroRNA-155,-185 and-193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma

  Bersani C; Mints M; Tertipis N; Haeggblom L; Nasman A; Romanitan M; Dalianis T; Ramqvist T
• Article: BLOOD. 2018;131(24):2670-2681

  Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma

  Ren W; Ye X; Su H; Li W; Liu D; Pirmoradian M; Wang X; Zhang B; Zhang Q; Chen L; Nie M; Liu Y; Meng B; Huang H; Jiang W; Zeng Y; Li W; Wu K; Hou Y; Wiman KG; Li Z; Zhang H; Peng R; Zhu S; Pan-Hammarstrom Q
• Article: CELL DEATH & DISEASE. 2018;9(5):439

  APR-246 reactivates mutant p53 by targeting cysteines 124 and 277

  Zhang Q; Bykov VJN; Wiman KG; Zawacka-Pankau J
• Article: BRAIN RESEARCH. 2018;1683:27-35

  Involvement of mGluR I in EphB/ephrinB reverse signaling activation induced retinal ganglion cell apoptosis in a rat chronic hypertension model

  Zhao Y; Li Q; Li X-Y; Cui P; Gao F; Zhu K; Li L-Z; Sun X-H; Wang Z
• Article: NATURE. 2018;555(7696):321-327

  The landscape of genomic alterations across childhood cancers.

  Gröbner SN; Worst BC; Weischenfeldt J; Buchhalter I; Kleinheinz K; Rudneva VA; Johann PD; Balasubramanian GP; Segura-Wang M; Brabetz S; Bender S; Hutter B; Sturm D; Pfaff E; Hübschmann D; Zipprich G; Heinold M; Eils J; Lawerenz C; Erkek S; Lambo S; Waszak S; Blattmann C; Borkhardt A; Kuhlen M; Eggert A; Fulda S; Gessler M; Wegert J; Kappler R; Baumhoer D; Burdach S; Kirschner-Schwabe R; Kontny U; Kulozik AE; Lohmann D; Hettmer S; Eckert C; Bielack S; Nathrath M; Niemeyer C; Richter GH; Schulte J; Siebert R; Westermann F; Molenaar JJ; Vassal G; Witt H; ICGC PedBrain-Seq Project; ICGC MMML-Seq Project; Burkhardt B; Kratz CP; Witt O; van Tilburg CM; Kramm CM; Fleischhack G; Dirksen U; Rutkowski S; Frühwald M; von Hoff K; Wolf S; Klingebiel T; Koscielniak E; Landgraf P; Koster J; Resnick AC; Zhang J; Liu Y; Zhou X; Waanders AJ; Zwijnenburg DA; Raman P; Brors B; Weber UD; Northcott PA; Pajtler KW; Kool M; Piro RM; Korbel JO; Schlesner M; Eils R; Jones DTW; Lichter P; Chavez L; Zapatka M; Pfister SM
• Review: NATURE REVIEWS CANCER. 2018;18(2):89-102

  Targeting mutant p53 for efficient cancer therapy

  Bykov VJN; Eriksson SE; Bianchi J; Wiman KG
• Article: FRONTIERS IN ONCOLOGY. 2018;7:323

  Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

  Zhang M; Heldin A; Palomar-Siles M; Ohlin S; Bykov VJN; Wiman KG
• Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(51):E10859-E10860

  High levels of EPAS1 are closely associated with key features of low-risk neuroblastoma

  Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Sodersten E; Schlisio S; Holmberg J
• Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(48):19607

  Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs (vol 280, pg 30384, 2005)

  Bykov VJN; Issaeva N; Zache N; Shilov A; Hultcrantz M; Bergman J; Selivanova G; Wiman KG
• Journal article: ENDOCRINOLOGY. 2017;158(10):3097-3108

  Bortezomib Alone and in Combination With Salinosporamid A Induces Apoptosis and Promotes Pheochromocytoma Cell Death In Vitro and in Female Nude Mice

  Bullova P; Cougnoux A; Marzouca G; Kopacek J; Pacak K
• Article: NATURE MEDICINE. 2017;23(10):1191-1202

  A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.

  Neumann JE; Wefers AK; Lambo S; Bianchi E; Bockstaller M; Dorostkar MM; Meister V; Schindler P; Korshunov A; von Hoff K; Nowak J; Warmuth-Metz M; Schneider MR; Renner-Müller I; Merk DJ; Shakarami M; Sharma T; Chavez L; Glass R; Chan JA; Taketo MM; Neumann P; Kool M; Schüller U
• Journal article: ONCOTARGET. 2017;8(34):56110-56125

  Vorinostat suppresses hypoxia signaling by modulating nuclear translocation of hypoxia inducible factor 1 alpha

  Zhang C; Yang C; Feldman MJ; Wang H; Pang Y; Maggio DM; Zhu D; Nesvick CL; Dmitriev P; Bullova P; Chittiboina P; Brady RO; Pacak K; Zhuang Z
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6137-E6146

  Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression

  Westerlund I; Shi Y; Toskas K; Fell SM; Li S; Surova O; Sodersten E; Kogner P; Nyman U; Schlisio S; Holmberg J
• Article: NEUROSCIENCE. 2017;355:71-83

  ACTIVATION OF DOPAMINE D1 RECEPTORS ENHANCES THE TEMPORAL SUMMATION AND EXCITABILITY OF RAT RETINAL GANGLION CELLS

  Cui P; Li X-Y; Zhao Y; Li Q; Gao F; Li L-Z; Yin N; Sun X-H; Wang Z
• Article: CELL DEATH & DISEASE. 2017;8(6):e2848

  Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

  Cheteh EH; Augsten M; Rundqvist H; Bianchi J; Sarne V; Egevad L; Bykov VJN; Ostman A; Wiman KG
• Article: ONCOTARGET. 2017;8(21):35339-35350

  Targeted sequencing of tonsillar and base of tongue cancer and human papillomavirus positive unknown primary of the head and neck reveals prognostic effects of mutated FGFR3

  Bersani C; Sivars L; Haeggblom L; DiLorenzo S; Mints M; Ahrlund-Richter A; Tertipis N; Munck-Wikland E; Nasman A; Ramqvist T; Dalianis T
• Article: GENES & DEVELOPMENT. 2017;31(10):1036-1053

  Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA

  Fell SM; Li S; Wallis K; Kock A; Surova O; Rraklli V; Hoefig CS; Li W; Mittag J; Henriksson MA; Kenchappa RS; Holmberg J; Kogner P; Schlisio S
• Editorial: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):418-421

  Introduction to Nobel Conference: 'The Cell Cycle and Cell Death in Disease'

  Wiman KG; Zhivotovsky B
• Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):483-495

  Understanding cell cycle and cell death regulation provides novel weapons against human diseases

  Wiman KG; Zhivotovsky B
• Article: ORAL ONCOLOGY. 2017;68:53-59

  A model using concomitant markers for predicting outcome in human papillomavirus positive oropharyngeal cancer

  Bersani C; Mints M; Tertipis N; Haeggblom L; Sivars L; Ahrlund-Richter A; Vlastos A; Smedberg C; Grun N; Munck-Wikland E; Nasman A; Ramqvist T; Dalianis T
• Corrigendum: CELL DEATH & DISEASE. 2017;8(4):e2751

  APR-246/PRIMA-1^MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase (vol 4, e881, 2013)

  Peng X; Zhang M-Q; Conserva F; Hosny G; Selivanova G; Bykov VJN; Arner ESJ; Wiman KG
• Journal article: ONCOTARGET. 2017;8(14):22313-22324

  Anthracyclines suppress pheochromocytoma cell characteristics, including metastasis, through inhibition of the hypoxia signaling pathway

  Ying P; Yang C; Schovanek J; Wang H; Bullova P; Caisova V; Gupta G; Wolf KI; Semenza GL; Zhuang Z; Pacak K
• Article: NATURE COMMUNICATIONS. 2017;8:14844

  Inhibiting the system x_(C)over-bar/glutathione axis selectively targets cancers with mutant-p53 accumulation

  Liu DS; Duong CP; Haupt S; Montgomery KG; House CM; Azar WJ; Pearson HB; Fisher OM; Read M; Guerra GR; Haupt Y; Cullinane C; Wiman KG; Abrahmsen L; Phillips WA; Clemons NJ
• Article: NATURE COMMUNICATIONS. 2017;8:14758

  Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.

  Feng W; Kawauchi D; Körkel-Qu H; Deng H; Serger E; Sieber L; Lieberman JA; Jimeno-González S; Lambo S; Hanna BS; Harim Y; Jansen M; Neuerburg A; Friesen O; Zuckermann M; Rajendran V; Gronych J; Ayrault O; Korshunov A; Jones DTW; Kool M; Northcott PA; Lichter P; Cortés-Ledesma F; Pfister SM; Liu H-K
• Article: BRAIN STRUCTURE & FUNCTION. 2017;222(2):813-830

  Activation of group I metabotropic glutamate receptors regulates the excitability of rat retinal ganglion cells by suppressing Kir and I _h

  Li Q; Cui P; Miao Y; Gao F; Li X-Y; Qian W-J; Jiang S-X; Wu N; Sun X-H; Wang Z
• Journal article: MOLECULAR CELL. 2016;64(5):1009

  Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage (vol 33, pg 462, 2009)

  Mahmoudi S; Henriksson S; Corcoran M; Mendez-Vidal C; Wiman KG; Farnebo M
• Article: BIOLOGICAL TRACE ELEMENT RESEARCH. 2016;173(2):345-353

  Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats

  Liu Y; Qiu C; Li W; Mu W; Li C; Guo M
• Journal article: ONCOTARGET. 2016;7(26):40531-40545

  Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models

  Bullova P; Cougnoux A; Abunimer L; Kopacek J; Pastorekova S; Pacak K
• Article: ONCOTARGET. 2016;7(23):34229-34239

  XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis

  Choo Z; Koh RYL; Wallis K; Koh TJW; Kuick CH; Sobrado V; Kenchappa RS; Loh AHP; Soh SY; Schlisio S; Chang KTE; Chen ZX
• Article: BIOLOGICAL TRACE ELEMENT RESEARCH. 2016;171(2):371-379

  Selenium Induces an Anti-tumor Effect Via Inhibiting Intratumoral Angiogenesis in a Mouse Model of Transplanted Canine Mammary Tumor Cells

  Li W; Guo M; Liu Y; Mu W; Deng G; Li C; Qiu C
• Article: JOURNAL OF OVARIAN RESEARCH. 2016;9(1):27

  Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer

  Fransson A; Glaessgen D; Alfredsson J; Wiman KG; Bajalica-Lagercrantz S; Mohell N
• Article: CELL CYCLE. 2016;15(9):1267-1275

  cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response

  Madapura HS; Salamon D; Wiman KG; Lain S; Klein E; Nagy N
• Journal article: ENDOCRINE-RELATED CANCER. 2016;23(5):L13-L16

  HIF2A gain-of-function mutations detected in duodenal gangliocytic paraganglioma

  Zhuang Z; Yang C; Ryska A; Ji Y; Hou Y; Graybill SD; Bullova P; Lubensky IA; Kloeppel G; Pacak K
• Article: GENES CHROMOSOMES & CANCER. 2016;55(5):418-427

  Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas.

  Sahm F; Jakobiec FA; Meyer J; Schrimpf D; Eberhart CG; Hovestadt V; Capper D; Lambo S; Ryzhova M; Schüller U; Zheludkova O; Kumirova E; Lichter P; von Deimling A; Jones DTW; Pfister SM; Kool M; Korshunov A
• Article: BRAIN RESEARCH. 2016;1635:95-104

  Suppression of outward K⁺ currents by activating dopamine D1 receptors in rat retinal ganglion cells through PKA and CaMKII signaling pathways

  Li Q; Wu N; Cui P; Gao F; Qian W-J; Miao Y; Sun X-H; Wang Z
• Meeting abstract: CANCER RESEARCH. 2016;76:a47

  Unusual suspects identified in neuroblastoma: An unexpected tumor suppression pathway

  Choo Z; Koh RYL; Wallis K; Koh TJW; Kuick CH; Sobrado V; Loh AHP; Soh SY; Schlisio S; Chang KTE; Chen ZX
• Review: FRONTIERS IN ONCOLOGY. 2016;6:21

  Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

  Bykov VJN; Zhang Q; Zhang M; Ceder S; Abrahmsen L; Wiman KG
• Journal article: ENDOCRINE PRACTICE. 2016;22(2):190-195

  AN AGGRESSIVE TEMPORAL BONE SDHC PARAGANGLIOMA ASSOCIATED WITH INCREASED HIF-2α SIGNALING

  Isaacson B; Bullova P; Frone M; Click A; Hamplova B; Rabaglia J; Woodruff S; Nwariaku F; Kathuria A; Pacak K; Ghayee HK
• Article: DEVELOPMENTAL CELL. 2016;36(2):164-178

  The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis

  Li S; Fell SM; Surova O; Smedler E; Wallis K; Chen ZX; Hellman U; Johnsen JI; Martinsson T; Kenchappa RS; Uhlen P; Kogner P; Schlisio S
• Article: ONCOTARGET. 2016;7(2):1895-1911

  Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis

  Bersani C; Huss M; Giacomello S; Xu L-D; Bianchi J; Eriksson S; Jerhammar F; Alexeyenko A; Vilborg A; Lundeberg J; Lui W-O; Wiman KG
• Journal article: AACE CLINICAL CASE REPORTS. 2016;2(3):e176-e181

  Functional Imaging Experience in a Germline Fumarate Hydratase Mutation–Positive Patient With Pheochromocytoma and Paraganglioma

  Nambuba J; Därr R; Janssen I; Bullova P; Adams KT; Millo C; Bourdeau I; Kassai A; Yang C; Kebebew E; Zhuang Z; Pacak K
• Article: HYPOXIA (AUCKL). 2016;4:15-27

  The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth

  Koivunen P; Fell SM; Lu W; Rabinowitz JD; Kung AL; Schlisio S
• Article: BIOLOGICAL TRACE ELEMENT RESEARCH. 2016;169(1):86-93

  Protective Role of Selenium Compounds on the Proliferation, Apoptosis, and Angiogenesis of a Canine Breast Cancer Cell Line

  Liu Y; Li W; Guo M; Li C; Qiu C
• Article: ORAL ONCOLOGY. 2015;51(12):1126-1131

  Studies on human papillomavirus (HPV) 16 E2, E5 and E7 mRNA in HPV-positive tonsillar and base of tongue cancer in relation to clinical outcome and immunological parameters

  Ramqvist T; Mints M; Tertipis N; Nasman A; Romanitan M; Dalianis T
• Journal article: ENDOCRINOLOGY. 2015;156(11):4094-4104

  Inhibitory Effect of the Noncamptothecin Topoisomerase I Inhibitor LMP-400 on Female Mice Models and Human Pheochromocytoma Cells

  Schovanek J; Bullova P; Tayem Y; Giubellino A; Wesley R; Lendvai N; Noelting S; Kopacek J; Frysak Z; Pommier Y; Kummar S; Pacak K
• Doctoral thesis: 2015

  Methodological approaches towards personalised cancer medicine

  Mints M
• Article: GUT. 2015;64(10):1506-1516

  APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

  Liu DSH; Read M; Cullinane C; Azar WJ; Fennell CM; Montgomery KG; Haupt S; Haupt Y; Wiman KG; Duong CP; Clemons NJ; Phillips WA
• Review: CELL DEATH AND DIFFERENTIATION. 2015;22(8):1239-1249

  TP53: an oncogene in disguise

  Soussi T; Wiman KG
• Article: CELL DEATH & DISEASE. 2015;6(6):e1794

  APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

  Mohell N; Alfredsson J; Fransson A; Uustalu M; Bystrom S; Gullbo J; Hallberg A; Bykov VJN; Bjorklund U; Wiman KG
• Journal article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(5):E710-E719

  Pituitary Adenoma With Paraganglioma/Pheochromocytoma (3PAs) and Succinate Dehydrogenase Defects in Humans and Mice

  Xekouki P; Szarek E; Bullova P; Giubellino A; Quezado M; Mastroyannis SA; Mastorakos P; Wassif CA; Raygada M; Rentia N; Dye L; Cougnoux A; Koziol D; Sierra MDLL; Lyssikatos C; Belyavskaya E; Malchoff C; Moline J; Eng C; Maher LJIII; Pacak K; Lodish M; Stratakis CA
• Journal article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2015;93(1):93-104

  Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia

  Yang C; Zhuang Z; Fliedner SMJ; Shankavaram U; Sun MG; Bullova P; Zhu R; Elkahloun AG; Kourlas PJ; Merino M; Kebebew E; Pacak K
• Article: PLOS ONE. 2014;9(11):e111125

  Expression of the p53 Target Wig-1 Is Associated with HPV Status and Patient Survival in Cervical Carcinoma

  Xu L-D; Muller S; Thoppe SR; Hellborg F; Kanter L; Lerner M; Zheng B; Lagercrantz SB; Grander D; Wallin KL; Wiman KG; Larsson C; Andersson S
• Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:135

  RNA helicase A is essential for 1p36 gene KIF1 Bβ tumor suppression in neuroblastomas

  Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Choo Z; Hellman U; Sandberg R; Kenchappa RS; Martinsson T; Johnsen JI; Kogner P; Schlisio S
• Article: ONCOGENE. 2014;33(35):4407-4417

  Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ

  Bersani C; Xu L-D; Vilborg A; Lui W-O; Wiman KG
• Review: FEBS LETTERS. 2014;588(16):2622-2627

  Mutant p53 reactivation by small molecules makes its way to the clinic

  Bykov VJN; Wiman KG
• Journal article: ENDOCRINOLOGY. 2014;155(7):2377-2390

  Combination of 13-Cis Retinoic Acid and Lovastatin: Marked Antitumor Potential In Vivo in a Pheochromocytoma Allograft Model in Female Athymic Nude Mice

  Noelting S; Giubellino A; Tayem Y; Young K; Lauseker M; Bullova P; Schovanek J; Anver M; Fliedner S; Korbonits M; Goeke B; Vlotides G; Grossman A; Pacak K
• Article: EXPERIMENTAL ONCOLOGY. 2014;36(2):67-71

  Impact of combinations of EGF, TGFβ, 17β-oestradiol, and inhibitors of corresponding pathways on proliferation of breast cancer cell lines.

  Mints M; Souchelnytskyi S
• Journal article: PLOS ONE. 2014;9(4):e90458

  High-Throughput Screening for the Identification of New Therapeutic Options for Metastatic Pheochromocytoma and Paraganglioma

  Giubellino A; Shankavaram U; Bullova P; Schovanek J; Zhang Y; Shen M; Patel N; Elkahloun A; Lee M-J; Trepel J; Ferrer M; Pacak K
• Journal article: AMERICAN JOURNAL OF PATHOLOGY. 2014;184(4):953-965

  Expression Pattern of Carbonic Anhydrase IX in Medullary Thyroid Carcinoma Supports a Role for RET-Mediated Activation of the HIF Pathway

  Takacova M; Bullova P; Simko V; Skvarkova L; Poturnajova M; Feketeova L; Babal P; Kivela AJ; Kuopio T; Kopacek J; Pastorek J; Parkkila S; Pastorekova S
• Article: CANCER DISCOVERY. 2014;4(4):434-451

  RNA Helicase A Is a Downstream Mediator of KIF1Bβ Tumor-Suppressor Function in Neuroblastoma

  Chen ZX; Wallis K; Fell SM; Sobrado VR; Hemmer MC; Ramskold D; Hellman U; Sandberg R; Kenchappa RS; Martinson T; Johnsen JI; Kogner P; Schlisio S
• Journal article: ENDOCRINOLOGY. 2014;155(1):27-32

  Succinate-to-Fumarate Ratio as a New Metabolic Marker to Detect the Presence of SDHB/D-related Paraganglioma: Initial Experimental and Ex Vivo Findings

  Lendvai N; Pawlosky R; Bullova P; Eisenhofer G; Patocs A; Veech RL; Pacak K
• Article: GENES & DEVELOPMENT. 2014;28(1):58-70

  Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

  Kelly GL; Grabow S; Glaser SP; Fitzsimmons L; Aubrey BJ; Okamoto T; Valente LJ; Robati M; Tai L; Fairlie WD; Lee EF; Lindstrom MS; Wiman KG; Huang DCS; Bouillet P; Rowe M; Rickinson AB; Herold MJ; Strasser A
• Editorial: CELL DEATH AND DIFFERENTIATION. 2013;20(11):1438-1439

  p53 talks to PARP: the increasing complexity of p53-induced cell death

  Wiman KG
• Article: CELL DEATH & DISEASE. 2013;4(10):e881

  APR-246/PRIMA-1^MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase

  Peng X; Zhang M-Q; Conserva F; Hosny G; Selivanova G; Bykov VJN; Arner ESJ; Wiman KG
• Journal article: PLOS ONE. 2013;8(2):e56083

  Targeting Heat Shock Protein 90 for the Treatment of Malignant Pheochromocytoma

  Giubellino A; Sourbier C; Lee M-J; Scroggins B; Bullova P; Landau M; Ying W; Neckers L; Trepel JB; Pacak K
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2152-2156

  Impaired epithelial differentiation of induced pluripotent stem cells from ectodermal dysplasia-related patients is rescued by the small compound APR-246/PRIMA-1^MET

  Shalom-Feuerstein R; Serror L; Aberdam E; Mueller F-J; van Bokhoven H; Wiman KG; Zhou H; Aberdam D; Petit I
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2157-2162

  APR-246/PRIMA-1^MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

  Shen J; van den Bogaard EH; Kouwenhoven EN; Bykov VJN; Rinne T; Zhang Q; Tjabringa GS; Gilissen C; van Heeringen SJ; Schalkwijk J; van Bokhoven H; Wiman KG; Zhou H
• Journal article: ENDOCRINOLOGY. 2013;154(2):646-655

  Combined Inhibition of mTORC1 and mTORC2 Signaling Pathways Is a Promising Therapeutic Option in Inhibiting Pheochromocytoma Tumor Growth: In Vitro and In Vivo Studies in Female Athymic Nude Mice

  Giubellino A; Bullova P; Noelting S; Turkova H; Powers JF; Liu Q; Guichard S; Tischler AS; Grossman AB; Pacak K
• Book chapter: P53 IN THE CLINICS. 2013;p. 257-273

  Targeting Mutant p53 for Improved Cancer Therapy

  Shen J; Bykov VJN; Wiman KG
• Article: CELL CYCLE. 2012;11(24):4563-4569

  p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP

  Madapura HS; Salamon D; Wiman KG; Lain S; Klein G; Klein E; Nagy N
• Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(29):3633-3639

  Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer

  Lehmann S; Bykov VJN; Ali D; Andren O; Cherif H; Tidefelt U; Uggla B; Yachnin J; Juliusson G; Moshfegh A; Paul C; Wiman KG; Andersson P-O
• Article: CELL DEATH & DISEASE. 2012;3(4):e298

  Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth

  Vilborg A; Bersani C; Wickstrom M; Segerstrom L; Kogner P; Wiman KG
• Editorial: CELL DEATH AND DIFFERENTIATION. 2012;19(1):180-183

  Mutant p53 protein, master regulator of human malignancies: a report on the fifth Mutant p53 Workshop

  Blandino G; Deppert W; Hainaut P; Levine A; Lozano G; Olivier M; Rotter V; Wiman K; Oren M
• Article: EXPERIMENTAL ONCOLOGY. 2011;33(3):193-195

  Proteomic strategy for detection of circulating tumor cell surface antigens.

  Mints M; Souchelnytskyi S
• Review: CELL DEATH AND DIFFERENTIATION. 2011;18(9):1434-1440

  The p53 target Wig-1: a regulator of mRNA stability and stem cell fate?

  Vilborg A; Bersani C; Wilhelm MT; Wiman KG
• Article: ENDOCRINE-RELATED CANCER. 2010;18(1):73-83

  Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

  Astuti D; Ricketts CJ; Chowdhury R; McDonough MA; Gentle D; Kirby G; Schlisio S; Kenchappa RS; Carter BD; Kaelin WGJ; Ratcliffe PJ; Schofield CJ; Latif F; Maher ER
• Article: ONCOGENE. 2010;29(49):6442-6451

  PRIMA-1^MET/APR-246 targets mutant forms of p53 family members p63 and p73

  Rokaeus N; Shen J; Eckhardt I; Bykov VJN; Wiman KG; Wilhelm MT
• Article: PLOS BIOLOGY. 2010;8(11):e1000521

  WRAP53 Is Essential for Cajal Body Formation and for Targeting the Survival of Motor Neuron Complex to Cajal Bodies

  Mahmoudi S; Henriksson S; Weibrecht I; Smith S; Soderberg O; Stromblad S; Wiman KG; Farnebo M
• Conference publication: JOURNAL OF MEDICAL GENETICS. 2010;47:S118

  Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma

  Astuti D; Ricketts C; Chowdury R; McDonough MA; Gentle D; Kirby G; Schlisio S; Racliffe P; Schofield CJ; Latif F; Maher ER
• Article: CARCINOGENESIS. 2010;31(8):1475-1482

  Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein

  Gouas DA; Shi H; Hautefeuille AH; Ortiz-Cuaran SL; Legros PC; Szymanska KJ; Galy O; Egevad LA; Abedi-Ardekani B; Wiman KG; Hantz O; de Fromentel CC; Chemin IA; Hainaut PL
• Review: ONCOGENE. 2010;29(30):4245-4252

  Pharmacological reactivation of mutant p53: from protein structure to the cancer patient

  Wiman KG
• Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2010;88(7):645-652

  Regulation of tumor suppressor p53 at the RNA level

  Vilborg A; Wilhelm MT; Wiman KG
• Article: CARCINOGENESIS. 2010;31(6):1045-1053

  Extract from Asteraceae Brachylaena ramiflora induces apoptosis preferentially in mutant p53-expressing human tumor cells

  Karimi M; Conserva F; Mahmoudi S; Bergman J; Wiman KG; Bykov VJN
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):85-89

  The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer

  Farnebo M; Bykov VJN; Wiman KG
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2010;36(6):1533-1539

  E6/E7 mRNA expression analysis: A test for the objective assessment of cervical adenocarcinoma in clinical prognostic procedure

  Hovland S; Muller S; Skomedal H; Mints M; Bergstrom J; Wallin K-L; Karlsen F; Johansson B; Andersson S
• Article: ONCOGENE. 2010;29(9):1329-1338

  Mutant p53 reactivation by PRIMA-1^MET induces multiple signaling pathways converging on apoptosis

  Lambert JMR; Moshfegh A; Hainaut P; Wiman KG; Bykov VJN
• Book chapter: RNA TECHNOLOGIES AND THEIR APPLICATIONS: RNA TECHNOLOGIES. 2010;p. 277-284

  Antisense RNA-Mediated Regulation of the p53 Tumor Suppressor

  Farnebo M; Wiman KG
• Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(10):4104-4112

  Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum

  Schlisio S
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(37):15756-15761

  The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

  Vilborg A; Glahder JA; Wilhelm MT; Bersani C; Corcoran M; Mahmoudi S; Rosenstierne M; Grander D; Farnebo M; Norrild B; Wiman KG
• Editorial: LANCET ONCOLOGY. 2009;10(9):913-919

  30 years and a long way into p53 research

  Hainaut P; Wiman KG
• Article: LEUKEMIA & LYMPHOMA. 2009;50(9):1512-1518

  Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival

  Paul E; Uggla B; Deneberg S; Bengtzen S; Hermansson M; Dahlman I; Rosenquist R; Wiman KG; Nahi H
• Article: CELL CYCLE. 2009;8(16):2509-2517

  Mutant p53 rescue and modulation of p53 redox state

  Bykov VJN; Lambert JMR; Hainaut P; Wiman KG
• Article: CANCER CELL. 2009;15(5):376-388

  PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

  Lambert JMR; Gorzov P; Veprintsev DB; Soderqvist M; Segerback D; Bergman J; Fersht AR; Hainaut P; Wiman KG; Bykov VJN
• Review: CANCER LETTERS. 2009;276(1):1-7

  Regulation of p53R2 and its role as potential target for cancer therapy

  Wang X; Zhenchuk A; Wiman KG; Albertioni F
• Article: MOLECULAR CANCER. 2009;8:23

  PRIMA-1^MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein

  Stuber G; Flaberg E; Petranyi G; Otvos R; Rokaeus N; Kashuba E; Wiman KG; Klein G; Szekely L
• Article: MOLECULAR CELL. 2009;33(4):462-471

  Wrap53, a Natural p53 Antisense Transcript Required for p53 Induction upon DNA Damage

  Mahmoudi S; Henriksson S; Corcoran M; Mendez-Vidal C; Wiman KG; Farnebo M
• Article: ONCOGENE. 2008;27(35):4854-4859

  Proteomic identification of p53-dependent protein phosphorylation

  Rahman-Roblick R; Hellman U; Becker S; Bader FG; Auer G; Wiman KG; Roblick UJ
• Article: CARCINOGENESIS. 2008;29(7):1428-1434

  In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249

  Shi H; Lambert JMR; Hautefeuille A; Bykov VJN; Wiman KG; Hainaut P; de Fromentel CC
• Article: FEBS LETTERS. 2008;582(15):2173-2177

  The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA

  Prahl M; Vilborg A; Palmberg C; Joernvall H; Asker C; Wiman KG
• Article: MOLECULAR ONCOLOGY. 2008;2(1):70-80

  Mutant p53 targeting by the low molecular weight compound STIMA-1

  Zache N; Lambert JMR; Rokaeus N; Shen J; Hainaut P; Bergman J; Wiman KG; Bykou VN
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 2008;141(4):445-453

  Mutated and non-mutated TP53 as targets in the treatment of leukaemia

  Nahi H; Selivanova G; Lehmann S; Mollgard L; Bengtzen S; Concha H; Svensson A; Wiman KG; Merup M; Paul C
• Article: GENES & DEVELOPMENT. 2008;22(7):884-893

  The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

  Schlisio S; Kenchappa RS; Vredeveld LCW; George RE; Stewart R; Greulich H; Shahriari K; Nguyen NV; Pigny P; Dahia PL; Pomeroy SL; Maris JM; Look AT; Meyerson M; Peeper DS; Carter BD; Kaelin WGJ
• Article: NATURE CELL BIOLOGY. 2008;10(3):361-369

  VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400

  Young AP; Schlisio S; Minamishima YA; Zhang Q; Li L; Grisanzio C; Signoretti S; Kaelin WGJ
• Article: RADIOTHERAPY AND ONCOLOGY. 2008;86(3):407-411

  PRIMA-1^met radiosensitizes prostate cancer cells independent of their MTp53-status

  Supiot S; Zhao H; Wiman K; Hill RP; Bristow RG
• Article: CELLULAR ONCOLOGY. 2008;30(5):411-418

  PRIMA-1^MET inhibits growth of mouse tumors carrying mutant p53

  Zache N; Lambert JMR; Wiman KG; Bykov VJN
• Article: MOLECULAR CELL. 2007;28(1):15-27

  pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-κB agonist Card9 by CK2

  Yang H; Minamishima YA; Yan Q; Schlisio S; Ebert BL; Zhang X; Zhang L; Kim WY; Olumi AF; Kaelin WGJ
• Review: CANCER CELL. 2007;12(4):303-312

  Shaping genetic alterations in human cancer: The p53 mutation paradigm

  Soussi T; Wiman KG
• Review: ONCOGENE. 2007;26(15):2243-2254

  Reactivation of mutant p53: molecular mechanisms and therapeutic potential

  Selivanova G; Wiman KG
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(13):5401-5406

  p53 targets identified by protein expression profiling

  Rahman-Roblick R; Roblick UJ; Hellman U; Conrotto P; Liu T; Becker S; Hirschberg D; Jornvall H; Auer G; Wiman KG
• Article: CELL DEATH AND DIFFERENTIATION. 2007;14(3):411-421

  Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis

  Liu T; Laurell C; Selivanova G; Lundeberg J; Nilsson P; Wiman KG
• Article: ONCOGENE. 2007;26(7):982-992

  PRIMA-1^MET induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins

  Rokaeus N; Klein G; Wiman KG; Szekely L; Mattsson K
• Book chapter: 25 YEARS OF P53 RESEARCH. 2007;p. 399-419

  Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy

  Selivanova G; Bykov VJN; Wiman KG
• Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2007;97:321-338

  Restoration of wild-type p53 function in human tumors: Strategies for efficient cancer therapy

  Wiman KG
• Article: FEBS LETTERS. 2006;580(18):4401-4408

  The p53-induced Wig-1 protein binds double-stranded RNAs with structural characteristics of siRNAs and miRNAs

  Vidal CM; Prahl M; Wiman KG
• Article: CELL DEATH AND DIFFERENTIATION. 2006;13(6):921-926

  Strategies for therapeutic targeting of the p53 pathway in cancer

  Wiman KG
• Book chapter: APOPTOSIS AND CANCER THERAPY. 2006;p. 891-912

  Cancer Therapy by Reactivation of the p53 Apoptosis Pathway

  Stridh H; Bykov VJN; Selivanova G; Wiman KG
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 2006;132(2):230-236

  PRIMA-1 induces apoptosis in acute myeloid leukaemia cells with p53 gene deletion

  Nahi H; Merup M; Lehmann S; Bengtzen S; Möllgård L; Selivanova G; Wiman KG; Paul C
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(34):30384-30391

  Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs

  Bykov VJN; Issaeva N; Zache N; Shilov A; Hultcrantz M; Bergman J; Selivanova G; Wiman KG
• Article: CANCER CELL. 2005;8(2):155-167

  Neuronal apoptosis linked to EgIN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer

  Lee S; Nakamura E; Yang HF; Wei WY; Linggi MS; Sajan MP; Farese RV; Freeman RS; Carter BD; Kaelin WGJ; Schlisio S
• Article: CANCER CELL. 2005;8(1):25-33

  The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

  Wei WY; Jin JP; Schlisio S; Harper JW; Kaelin WGJ
• Article: ONCOGENE. 2005;24(21):3484-3491

  PRIMA-1^MET synergizes with cisplatin to induce tumor cell apoptosis

  Bykov VJN; Zache N; Stridh H; Westman J; Bergman J; Selivanova G; Wiman KG
• Article: ONCOGENE. 2005;24(8):1320-1327

  hTERT antagonizes p53-induced apoptosis independently of telomerase activity

  Rahman R; Latonen L; Wiman KG
• Journal article: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2005;70(1):1

  CANCER-RELEVANT CULLIN-RING UBIQUITIN LIGASES

  Kaelin WG; Harper JW; Jin J; Kim W; Lee S; Reddy A; Safran M; Schlisio S; Wei W; Yang H; Zhang G-J
• Book chapter: ZINC FINGER PROTEINS: MOLECULAR BIOLOGY INTELLIGENCE UNIT. 2005;p. 76-79

  Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA

  Mendez-Vidal C; Hellborg F; Wilhelm MT; Tarkowska M; Wiman KG
• Article: JOURNAL OF VISION. 2004;4(12):993-1005

  Perceptual learning in contrast discrimination: The effect of contrast uncertainty

  Adini Y; Wilkonsky A; Haspel R; Tsodyks M; Sagi D
• Article: GENES & DEVELOPMENT. 2004;18(23):2941-2951

  A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription

  Giangrande PH; Zhu WC; Schlisio S; Sun X; Mori S; Gaubatz S; Nevins JR
• Article: BRITISH JOURNAL OF HAEMATOLOGY. 2004;127(3):285-291

  Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion

  Nahi H; Lehmann S; Mollgard L; Bengtzen S; Selivanova G; Wiman KG; Paul C; Merup M
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2004;24(6):1559-1564

  The p53-induced Wig-1 zinc finger protein is highly conserved from fish to man

  Hellborg F; Wiman KG
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(23):13303-13307

  Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

  Issaeva N; Friedler A; Bozko P; Wiman KG; Fersht AR; Selivanova G
• Article: EUROPEAN JOURNAL OF CANCER. 2003;39(13):1828-1834

  Small molecules that reactivate mutant p53

  Bykov VJN; Selivanova G; Wiman KG
• Article: ONCOGENE. 2003;22(32):4993-5005

  Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts

  Lindström MS; Wiman KG
• Article: ANNALS OF MEDICINE. 2003;35(7):458-465

  Novel cancer therapy by reactivation of the p53 apoptosis pathway

  Bykov VJN; Wiman KG
• Article: CARCINOGENESIS. 2002;23(12):2011-2018

  Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database

  Bykov VJN; Issaeva N; Selivanova G; Wiman KG
• Article: EMBO JOURNAL. 2002;21(21):5775-5786

  Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function

  Schlisio S; Halperin T; Vidal M; Nevins JR
• Article: SEMINARS IN CANCER BIOLOGY. 2002;12(5):381-387

  Role of genetic and epigenetic changes in Burkitt lymphoma

  Lindström MS; Wiman KG
• Article: INVESTIGATIONAL NEW DRUGS. 2002;20(3):253-259

  A novel high-through-put assay for screening of pro-apoptotic drugs

  Hägg M; Bivén K; Ueno T; Rydlander L; Björklund P; Wiman KG; Shoshan M; Linder S
• Article: FEBS LETTERS. 2002;524(1-3):69-72

  Identification of functional p53-binding motifs in the mouse wig-1 promoter

  Wilhelm MT; Méndez-Vidal C; Wiman KG
• Article: CANCER LETTERS. 2002;180(2):211-221

  A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF

  Hashemi J; Lindström MS; Asker C; Platz A; Hansson J; Wiman KG
• Article: NUCLEIC ACIDS RESEARCH. 2002;30(9):1991-1996

  The p53-induced mouse zinc finger protein wig-1 binds double-stranded RNA with high affinity

  Méndez-Vidal C; Wilhelm MT; Hellborg F; Qian W; Wiman KG
• Article: ONCOGENE. 2002;21(14):2119-2129

  Characterization of the p53-rescue drug CP-31398 in vitro and in living cells

  Rippin TM; Bykov VJN; Freund SMV; Selivanova G; Wiman KG; Fersht AR
• Article: NATURE MEDICINE. 2002;8(3):282-288

  Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

  Bykov VJN; Issaeva N; Shilov A; Hultcrantz M; Pugacheva E; Chumakov P; Bergman J; Wiman KG; Selivanova G
• Article: ONCOGENE. 2001;20(39):5466-5474

  Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein

  Hellborg F; Qian W; Mendez-Vidal C; Asker C; Kost-Alimova M; Wilhelm M; Imreh S; Wiman KG
• Article: ONCOGENE. 2001;20(17):2171-2177

  p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

  Lindström MS; Klangby U; Wiman KG
• Article: BRAIN PATHOLOGY. 2001;11(2):159-168

  p14^ARF Deletion and methylation in genetic pathways to glioblastomas

  Nakamura M; Watanabe T; Klangby U; Asker C; Wiman K; Yonekawa Y; Kleihues P; Ohgaki H
• Article: APOPTOSIS. 2001;6(1-2):133-137

  Inactivation of Myc-induced p53-dependent apoptosis in human tumors

  Henriksson M; Selivanova G; Lindström M; Wiman KG
• Article: ONCOGENE. 2000;19(45):5123-5133

  Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells

  Xu DW; Wang Q; Gruber A; Björkholm M; Chen ZG; Zaid A; Selivanova G; Peterson C; Wiman KG; Pisa P
• Article: CANCER RESEARCH. 2000;60(18):5278-5283

  Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: Functional impact

  Girnita L; Girnita A; Brodin B; Xie YT; Nilsson G; Dricu A; Lundeberg J; Wejde J; Bartolazzi A; Wiman KG; Larsson O
• Article: EXPERIMENTAL CELL RESEARCH. 2000;256(2):400-410

  Immunolocalization of human p14^ARF to the granular component of the interphase nucleolus

  Lindström MS; Klangby U; Inoue R; Pisa P; Wiman KG; Asker CE
• Article: GENE. 2000;246(1-2):247-254

  p53 splice acceptor site mutation and increased HsRAD51 protein expression in Bloom's syndrome GM1492 fibroblasts

  Magnusson KP; Sandström M; Ståhlberg M; Larsson M; Flygare J; Hellgren D; Wiman KG; Ljungquist S
• Article: MOLECULAR CANCER RESEARCH. 2000;11(1):31-39

  Polyoma virus middle T and small t antigens cooperate to antagonize p53-induced cell cycle arrest and apoptosis

  Qian W; Wiman KG
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;265(1):1-6

  p53-induced apoptosis as a safeguard against cancer

  Asker C; Wiman KG; Selivanova G
• Article: ANTICANCER RESEARCH. 1999;19(4B):2939-2943

  Induction of the human ARF protein by serum starvation

  Inoue R; Asker C; Klangby U; Pisa P; Wiman KG
• Journal article: EXPERT OPINION ON THERAPEUTIC TARGETS. 1999;3(2):347-353

  p53 as a target for improved cancer therapy

  Wiman KG
• Article: FEMS MICROBIOLOGY LETTERS. 1999;174(1):117-123

  The Bacillus subtilis regulator protein SpoIIE shares functional and structural similarities with eukaryotic protein phosphatases 2C

  Schroeter R; Schlisio S; Lucet I; Yudkin M; Borriss R
• Article: MOLECULAR AND CELLULAR BIOLOGY. 1999;19(5):3395-3402

  Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain

  Selivanova G; Ryabchenko L; Jansson E; Iotsova V; Wiman KG
• Review: MEDICAL ONCOLOGY. 1998;15(4):222-228

  New p53-based anti-cancer therapeutic strategies

  Wiman KG
• Article: ONCOGENE. 1998;17(18):2333-2337

  Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation?

  Magnusson KP; Satalino R; Qian W; Klein G; Wiman KG
• Journal article: BLOOD. 1998;91(5):1680-1687

  p16/INK4a and p15/INK4b Gene Methylation and Absence of p16/INK4a mRNA and Protein Expression in Burkitt's Lymphoma

  Klangby U; Okan I; Magnusson KP; Wendland M; Lind P; Wiman KG
• Article: BLOOD. 1998;91(5):1680-1687

  p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma

  Klangby U; Okan I; Magnusson KP; Wendland M; Lind P; Wiman KG
• Article: SEMINARS IN CANCER BIOLOGY. 1998;8(5):369-378

  Reactivation of mutant p53: a new strategy for cancer therapy

  Selivanova G; Kawasaki T; Ryabchenko L; Wiman KG
• Article: ONCOGENE. 1997;15(22):2699-2704

  Wig-1, a new p53-induced gene encoding a zinc finger protein

  VarmehZiaie S; Okan I; Wang YS; Magnusson KP; Warthoe P; Strauss M; Wiman KG
• Review: EXPERIMENTAL CELL RESEARCH. 1997;237(1):14-18

  p53: Emergency brake and target for cancer therapy

  Wiman KG
• Review: LAKARTIDNINGEN. 1997;94(38):3268-3272

  [New transcription factor-based cancer therapy. Gene therapy, cell lysis, reactivation of p53 are the new approaches].

  Wiman KG
• Editorial: NATURE MEDICINE. 1997;3(8):839-840

  An old acquaintance resurfaces in human mesothelioma

  Wiman KG; Klein G
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1997;11(1):97-104

  p53 overexpression in normal and dysplastic tissues adjacent to p53 negative squamous cell carcinomas of the head and neck

  MunckWikland E; Blegen H; LewensohnFuchs I; Malec M; Auer G; Kuylenstierna R; Dalianis T; Wiman KG; Lindholm J
• Article: NATURE MEDICINE. 1997;3(6):632-638

  Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

  Selivanova G; Iotsova V; Okan I; Fritsche M; Strom M; Groner B; Grafstrom RC; Wiman KG
• Article: JOURNAL OF GENERAL VIROLOGY. 1997;78:893-903

  Role of p53 mutation in polyomavirus-induced tumorigenesis

  Wang Q; Kashuba E; Magnusson KP; Pokrovskaja K; Okan I; Klein G; Wiman KG
• Article: MOLECULAR CANCER RESEARCH. 1997;8(2):121-131

  Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice

  Shick L; Carman JH; Choi JK; Somasundaram K; Burrell M; Hill DE; Zeng YX; Wang YS; Wiman KG; Salhany K; Kadesch TR; Monroe JG; Donehower LA; ElDeiry WS
• Article: MOLECULAR CANCER RESEARCH. 1996;7(12):1723-1732

  Phenotype-related differences in the expression of D-type cyclins in human B cell-derived lines

  Pokrovskaja K; EhlinHenriksson B; Bartkova J; Bartek J; Scuderi R; Szekely L; Wiman KG; Klein G
• Article: NUCLEIC ACIDS RESEARCH. 1996;24(18):3560-3567

  The single-stranded DNA end binding site of p53 coincides with the C-terminal regulatory region

  Selivanova G; Iotsova V; Kiseleva E; Strom M; Bakalkin G; Grafstrom RC; Wiman KG
• Article: INTERNATIONAL JOURNAL OF CANCER. 1996;67(1):106-112

  Wild-type p53-induced apoptosis in a Burkitt lymphoma cell line is inhibited by interferon gamma

  Sangfelt O; Einhorn S; Bjorklund AC; Wiman KG; Okan I; Grander D
• Article: ONCOGENE. 1996;12(12):2731-2735

  Abrogation of p53-induced G1 arrest by the HPV 16 E7 protein does not inhibit p53-induced apoptosis

  Wang YS; Okan I; Pokrovskaja K; Wiman KG
• Article: INTERNATIONAL JOURNAL OF CANCER. 1996;66(3):322-325

  Frequent expression of bcl-2 in renal-cell carcinomas carrying wild-type p53

  Tomita Y; Bilim V; Kawasaki T; Takahashi K; Okan I; Magnusson KP; Wiman KG
• Article: BLOOD. 1996;87(8):3360-3367

  Cyclin E overexpression in relapsed adult acute lymphoblastic leukemias of B-cell lineage

  Scuderi R; Palucka KA; Pokrovskaja K; Bjorkholm M; Wiman KG; Pisa P
• Article: CURRENT OPINION IN CELL BIOLOGY. 1995;7(6):835-842

  WHAT IS THE RESTRICTION POINT

  ZETTERBERG A; LARSSON O; WIMAN KG
• Article: ONCOGENE. 1995;11(10):1963-1969

  MOUSE AND RAT B-MYC SHARE AMINO-ACID-SEQUENCE HOMOLOGY WITH THE C-MYC TRANSCRIPTIONAL ACTIVATOR DOMAIN AND CONTAIN A B-MYC SPECIFIC CARBOXY-TERMINAL REGION

  ASKER CE; MAGNUSSON KP; PICCOLI SP; ANDERSSON K; KLEIN G; COLE MD; WIMAN KG
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;7(5):1123-1128

  IDENTIFICATION OF GENES OVEREXPRESSED IN THE SQCC/Y1 HUMAN BUCCAL CARCINOMA CELL-LINE USING THE DIFFERENTIAL DISPLAY METHOD

  SUNDQVIST K; IOTSOVA V; ZIAIE SV; WIMAN KG; HOOG C; GRAFSTROM RC
• Article: CARCINOGENESIS. 1995;16(10):2515-2521

  CHARACTERIZATION OF HUMAN BUCCAL EPITHELIAL-CELLS TRANSFECTED WITH THE SIMIAN-VIRUS-40 T-ANTIGEN GENE

  KULKARNI PS; SUNDQVIST K; BETSHOLTZ C; HOGLUND P; WIMAN KG; ZHIVOTOVSKY B; BERTOLERO F; LIU Y; GRAFSTROM RC
• Article: JOURNAL OF GENERAL VIROLOGY. 1995;76:2423-2432

  REVERSIBLE NUCLEOLAR TRANSLOCATION OF EPSTEIN-BARR VIRUS-ENCODED EBNA-5 AND HSP70 PROTEINS AFTER EXPOSURE TO HEAT-SHOCK OR CELL-DENSITY CONGESTION

  SZEKELY L; JIANG WQ; POKROVSKAJA K; WIMAN KG; KLEIN G; RINGERTZ N
• Article: ONCOGENE. 1995;11(6):1027-1031

  THE EBV-ENCODED LMP1 PROTEIN INHIBITS P53-TRIGGERED APOPTOSIS BUT NOT GROWTH ARREST

  OKAN I; WANG YS; CHEN F; HU LF; IMREH S; KLEIN G; WIMAN KG
• Other: GENE. 1995;162(2):231-234

  A SPLICE DONOR SITE MUTATION RESULTS IN THE INSERTION OF 5 EXTRA AMINO-ACIDS INTO P53 FROM SEWA MOUSE SARCOMA-CELLS

  MAGNUSSON KP; MINAROVITS J; KLEIN G; WIMAN KG
• Article: EUROPEAN JOURNAL OF CANCER PART B: ORAL ONCOLOGY. 1995;31B(5):328-332

  Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma

  Qian W; Hu LF; Chen F; Wang YS; Magnusson KP; Kashuba E; Klein G; Wiman KG
• Article: MOLECULAR CANCER RESEARCH. 1995;6(9):1071-1075

  BCL-2 INHIBITS WILD-TYPE P53-TRIGGERED APOPTOSIS BUT NOT G(1) CELL-CYCLE ARREST AND TRANSACTIVATION OF WAF1 AND BAX

  WANG YS; OKAN I; SZEKELY L; KLEIN G; WIMAN KG
• Article: INTERNATIONAL JOURNAL OF CANCER. 1995;61(5):683-691

  RB-RECONSTITUTED HUMAN RETINOBLASTOMA CELLS FORM RB-POSITIVE INTRAOCULAR AND INTRACEREBRAL BUT NOT SUBCUTANEOUS TUMORS IN SCID MICE

  SZEKELY L; WANG YS; KLEIN G; WIMAN KG
• Other: ONCOGENE. 1995;10(9):1869-1874

  RESTING B-CELLS, EBV-INFECTED B-BLASTS AND ESTABLISHED LYMPHOBLASTOID CELL-LINES DIFFER IN THEIR RB, P53 AND EBNA-5 EXPRESSION PATTERNS

  SZEKELY L; POKROVSKAJA K; JIANG WQ; SELIVANOVA G; LOWBEER M; RINGERTZ N; WIMAN KG; KLEIN G
• Article: NUCLEIC ACIDS RESEARCH. 1995;23(3):362-369

  P53 BINDS SINGLE-STRANDED-DNA ENDS THROUGH THE C-TERMINAL DOMAIN AND INTERNAL DNA SEGMENTS VIA THE MIDDLE DOMAIN

  BAKALKIN G; SELIVANOVA G; YAKOVLEVA T; KISELEVA E; KASHUBA E; MAGNUSSON KP; SZEKELY L; KLEIN G; TERENIUS L; WIMAN KG
• Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 1995;6(1):27-29

  IN FRAME DELETION OF INTRON-7 IN THE P53 GENE IN A HUMAN TONSIL TUMOR

  MAGNUSSON KP; BERKE Z; MUNCKWIKLAND E; LEWENSOHNFUCHS I; KLEIN G; DALLIANIS T; WIMAN KG
• Review: MECHANISMS AND THERAPY OF LIVER CANCER. 1995;66:143-180

  P53 - A CELL-CYCLE REGULATOR ACTIVATED BY DNA-DAMAGE

  SELIVANOVA G; WIMAN KG
• Journal article: CANCER RESEARCH. 1994;54(5):1169-1174

  WAF1/CIP1 IS INDUCED IN P53-MEDIATED G(1) ARREST AND APOPTOSIS

  ELDEIRY WS; HARPER JW; OCONNOR PM; VELCULESCU VE; CANMAN CE; JACKMAN J; PIETENPOL JA; BURRELL M; HILL DE; WANG YS; WIMAN KG; MERCER WE; KASTAN MB; KOHN KW; ELLEDGE SJ; KINZLER KW; VOGELSTEIN B
• Journal article: ONCOGENE. 1993;8(12):3427-3431

  WILD-TYPE P53-TRIGGERED APOPTOSIS IS INHIBITED BY BCL-2 IN A V-MYC-INDUCED T-CELL LYMPHOMA LINE

  WANG YS; SZEKELY L; OKAN I; KLEIN G; WIMAN KG
• Journal article: FASEB JOURNAL. 1993;7(10):841-845

  THE RETINOBLASTOMA GENE - ROLE IN CELL-CYCLE CONTROL AND CELL-DIFFERENTIATION

  WIMAN KG
• Journal article: ONCOGENE. 1993;8(6):1495-1500

  WILD-TYPE P53 INDUCED APOPTOSIS IN A BURKITT-LYMPHOMA (BL) LINE THAT CARRIES MUTANT P53

  RAMQVIST T; MAGNUSSON KP; WANG YS; SZEKELY L; KLEIN G; WIMAN KG
• Journal article: MOLECULAR CANCER RESEARCH. 1993;4(6):467-473

  RECONSTITUTION OF WILD-TYPE P53 EXPRESSION TRIGGERS APOPTOSIS IN A P53-NEGATIVE V-MYC RETROVIRUS-INDUCED T-CELL LYMPHOMA LINE

  WANG YS; RAMQVIST T; SZEKELY L; AXELSON H; KLEIN G; WIMAN KG
• Journal article: LAKARTIDNINGEN. 1992;89(39):3169-3174

  [Tumor suppressor genes: mutations in RB and p53 genes are significant carcinogenic factors].

  Wiman KG
• Journal article: ONCOGENE. 1991;6(9):1633-1639

  MUTANT P53 DETECTED IN A MAJORITY OF BURKITT-LYMPHOMA CELL-LINES BY MONOCLONAL-ANTIBODY PAB240

  WIMAN KG; MAGNUSSON KP; RAMQVIST T; KLEIN G
• Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1984;81(21):6798-6802

  ACTIVATION OF A TRANSLOCATED C-MYC GENE - ROLE OF STRUCTURAL ALTERATIONS IN THE UPSTREAM REGION

  WIMAN KG; CLARKSON B; HAYDAY AC; SAITO H; TONEGAWA S; HAYWARD WS
• Journal article: BIOCHEMISTRY. 1982;21(21):5351-5358

  PURIFICATION AND PARTIAL AMINO-ACID-SEQUENCE OF PAPAIN-SOLUBILIZED CLASS-II TRANSPLANTATION ANTIGENS

  WIMAN K; CLAESSON L; RASK L; TRAGARDH L; PETERSON PA
• Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1982;16(4):303-308

  ISOLATION AND IDENTIFICATION OF A CDNA CLONE CODING FOR AN HLA-DR TRANSPLANTATION ANTIGEN ALPHA-CHAIN

  GUSTAFSSON K; BILL P; LARHAMMAR D; WIMAN K; CLAESSON L; SCHENNING L; SERVENIUS B; SUNDELIN J; RASK L; PETERSON PA
• Journal article: CELL. 1982;30(1):153-161

  ALPHA-CHAIN OF HLA-DR TRANSPLANTATION ANTIGENS IS A MEMBER OF THE SAME PROTEIN SUPERFAMILY AS THE IMMUNOGLOBULINS

  LARHAMMAR D; GUSTAFSSON K; CLAESSON L; BILL P; WIMAN K; SCHENNING L; SUNDELIN J; WIDMARK E; PETERSON PA; RASK L
• Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1982;79(12):3687-3691

  COMPLETE AMINO-ACID-SEQUENCE OF AN HLA-DR ANTIGEN-LIKE BETA-CHAIN AS PREDICTED FROM THE NUCLEOTIDE-SEQUENCE - SIMILARITIES WITH IMMUNOGLOBULINS AND HLA-A, HLA-B, AND HLA-C ANTIGENS

  LARHAMMAR D; SCHENNING L; GUSTAFSSON K; WIMAN K; CLAESSON L; RASK L; PETERSON PA
• Journal article: CELL. 1982;29(1):61-69

  MEMBRANE INSERTION AND OLIGOMERIC ASSEMBLY OF HLA-DR HISTOCOMPATIBILITY ANTIGENS

  KVIST S; WIMAN K; CLAESSON L; PETERSON PA; DOBBERSTEIN B
• Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1982;79(6):1703-1707

  ISOLATION AND IDENTIFICATION OF A CDNA CLONE CORRESPONDING TO AN HLA-DR ANTIGEN BETA-CHAIN

  WIMAN K; LARHAMMAR D; CLAESSON L; GUSTAFSSON K; SCHENNING L; BILL P; BOHME J; DENARO M; DOBBERSTEIN B; HAMMERLING U; KVIST S; SERVENIUS B; SUNDELIN J; PETERSON PA; RASK L
• Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1982;16(5):447

  THE HLA-DR ANTIGEN ALFA CHAIN IS A MEMBER OF THE SAME PROTEIN SUPER-FAMILY AS THE IMMUNOGLOBULINS

  GUSTAFSSON K; BILL P; SCHENNING L; WIDMARK E; LARHAMMAR D; WIMAN K; RASK L; PETERSON PA
• Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1981;14(6):617-622

  EVOLUTIONARY RELATIONSHIP BETWEEN HLA-DR ANTIGEN BETA-CHAINS, HLA-A, B-ANTIGEN, C-ANTIGEN SUBUNITS AND IMMUNOGLOBULIN-CHAINS

  LARHAMMAR D; WIMAN K; SCHENNING L; CLAESSON L; GUSTAFSSON K; PETERSON PA; RASK L
• Journal article: NATURE. 1981;292(5818):78-81

  STRUCTURE OF C-TERMINAL HALF OF 2 H-2-ANTIGENS FROM CLONED MESSENGER-RNA

  BREGEGERE F; ABASTADO JP; KVIST S; RASK L; LALANNE JL; GAROFF H; CAMI B; WIMAN K; LARHAMMAR D; PETERSON PA; GACHELIN G; KOURILSKY P; DOBBERSTEIN B
• Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1981;78(5):2772-2776

  CDNA CLONE CODING FOR PART OF A MOUSE H-2D MAJOR HISTOCOMPATIBILITY ANTIGEN

  KVIST S; BREGEGERE F; RASK L; CAMI B; GAROFF H; DANIEL F; WIMAN K; LARHAMMAR D; ABASTADO JP; GACHELIN G; PETERSON PA; DOBBERSTEIN B; KOURILSKY P
• Journal article: LAKARTIDNINGEN. 1981;78(13):1309-1318

  [Cell surface receptors and their disorders].

  Bergström K; Boberg J; Dahlberg PA; Hall K; Johansson SG; Karlsson A; Smith U; Wiman K
• Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1980;77(2):1129-1133

  COMPLETE AMINO-ACID-SEQUENCE OF POOLED PAPAIN-SOLUBILIZED HLA-A, HLA-B, AND HLA-C ANTIGENS - RELATEDNESS TO IMMUNOGLOBULINS AND INTERNAL HOMOLOGIES

  TRAGARDH L; RASK L; WIMAN K; FOHLMAN J; PETERSON PA
• Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1979;76(11):5839-5842

  AMINO-ACID SEQUENCE OF AN IMMUNOGLOBULIN-LIKE HLA-ANTIGEN HEAVY-CHAIN DOMAIN

  TRAGARDH L; RASK L; WIMAN K; FOHLMAN J; PETERSON PA
• Journal article: BIOCHEMISTRY. 1979;18(11):2218-2226

  CHEMICAL, PHYSICAL-CHEMICAL, AND IMMUNOLOGICAL PROPERTIES OF PAPAIN-SOLUBILIZED HUMAN TRANSPLANTATION ANTIGENS

  TRAGARDH L; CURMAN B; WIMAN K; RASK L; PETERSON PA
• Journal article: BIOCHEMISTRY. 1979;18(7):1322-1328

  FRAGMENTATION OF THE HUMAN TRANSPLANTATION ANTIGEN HEAVY-CHAIN BY LIMITED PROTEOLYSIS, ACID CLEAVAGE, AND CYANOGEN-BROMIDE TREATMENT

  TRAGARDH L; WIMAN K; RASK L; PETERSON PA
• Journal article: FEBS JOURNAL. 1979;95(2):265-273

  SIMILARITIES BETWEEN IMMUNOGLOBULINS AND TRANSPLANTATION ANTIGENS IN AMINO-ACID-SEQUENCE AND DISULFIDE-BOND DISTRIBUTION

  WIMAN K; TRAGARDH L; RASK L; PETERSON PA
• Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1979;9(3):190-195

  DEMONSTRATION OF HLA-DR-LIKE ANTIGENS ON MILK-FAT GLOBULE MEMBRANES

  WIMAN K; CURMAN B; TRAGARDH L; PETERSON PA
• Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1979;10(6):597-600

  PRIMARY STRUCTURE OF POOLED, PAPAIN-SOLUBILIZED HLA-A, HLA-B, AND HLA-C ANTIGENS

  TRAGARDH L; RASK L; WIMAN K; PETERSON PA
• Journal article: NATURE. 1978;276(5689):711-713

  OCCURRENCE OF IA ANTIGENS ON TISSUES OF NON-LYMPHOID ORIGIN

  WIMAN K; CURMAN B; FORSUM U; KLARESKOG L; MALMNASTJERNLUND U; RASK L; TRAGARDH L; PETERSON PA
• Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1978;8(6):563-568

  AMINO-ACID SEQUENCE HOMOLOGY BETWEEN HLA-A,B,C ANTIGENS, BETA-MICROGLOBULIN AND IMMUNOGLOBULINS

  TRAGARDH L; WIMAN K; RASK L; PETERSON PA
• Visa fler

Medarbetare och kontakt

Gruppledare

• 

  Susanne Schlisio

  Lektor | Docent

  Telefon +46852487117

  E-postadress susanne.schlisio@ki.se

  Plasticitet, tumörheterogenitet och metastasering vid neuroblastom och paragangliom

Alla medarbetare i gruppen

• 

  Petra Bullová

  Forskningsspecialist

  E-postadress petra.bullova@ki.se
• 

  Peng Cui

  Forskningsspecialist

  E-postadress peng.cui@ki.se
• Basile Cornelius Dalarun

  Doktorand

  E-postadress basile.dalarun@ki.se
• Anastasiia Kuliagina

  Utbytestudent

  E-postadress anastasiia.kuliagina@ki.se
• 

  Sander Lambo

  Biträdande Lektor

  Telefon +46852482391

  E-postadress sander.lambo@ki.se
• 

  Wenyu Li

  Anknuten till Forskning

  E-postadress wenyu.li@ki.se
• Zinan Li

  Doktorand

  E-postadress zinan.li@ki.se
• Michael Mints

  Anknuten till Forskning | Docent

  E-postadress michael.mints@ki.se
• 

  Lidiya Mykhaylechko

  Postdoktorala Studier

  E-postadress lidiya.mykhaylechko@ki.se
• Valeriy Paramonov

  Postdoktor

  E-postadress valeriy.paramonov@ki.se
• Valentin Poltorachenko

  Anknuten till Forskning

  E-postadress valentin.poltorachenko@ki.se
• 

  Nicholas Smith

  Postdoktorala Studier

  E-postadress nicholas.smith@ki.se
• 

  Jorrit Jilles Stada

  Doktorand

  E-postadress jorrit.stada@ki.se
• Amos Tuval Wilkonsky

  Postdoktor

  E-postadress amos.tuval@ki.se
• 

  Cheng Wei

  Postdoktorala Studier

  E-postadress cheng.wei@ki.se
• 

  Klas Wiman

  Professor, Senior

  E-postadress klas.wiman@ki.se
• 

  Jiacheng Joey Zhu

  Doktorand

  E-postadress jiacheng.zhu@ki.se

Team

Team Wiman

Foto: Gunnar Ask

Team Wiman

Basal och translationell cancerforskning med fokus på tumörsuppressorn p53 och ny p53-riktad cancerbehandling.

Team Lambo

Foto: N/A

Team Lambo

Vår forskning fokuserar på att identifiera epigenetiska mönster som driver uppkomst och utveckling av barncancer. Med avancerade sekvenseringsmetoder, inklusive DNA-metyleringsanalys på encellsnivå, studerar vi tumörers epigenetiska heterogenitet och cellulära plasticitet. Genom att analysera och påverka dessa mönster undersöker vi bakomliggande mekanismer och utvecklar maskininlärningsbaserade biomarkörer för framtida diagnostik och behandling.