Ortopedi

Forskargruppsledare: Lars Weidenhielm, professor

Professor/överläkare

Lars Weidenhielm

Enhet:	Ortopedi
E-post:	Lars.Weidenhielm@ki.se

Medlemmar i gruppen

Universitetslektor/klinisk anställning

Paul Ackermann

Enhet:	Administration
E-post:	Paul.Ackermann@ki.se

Universitetsadjunkt, adj

Wilhelmina Ekström

Enhet:	Ortopedi
E-post:	Wilhelmina.Ekstrom@ki.se

Anknuten

Rikard Wedin

Telefon:	51772757
Enhet:	Ortopedi
E-post:	rikard.wedin@ki.se

Anknuten

Per Wretenberg

Enhet:	Ortopedi
E-post:	Per.Wretenberg@ki.se

Forskningsområden

Trauma

Forskningsledare Karl-Åke Jansson

E-post: karl‑ake.jansson@karolinska.se 

Pågående forskningsprojekt - Trauma

• Long-term opioid use after acetabular fractures
• Bone mineral density, body composition and trauma mechanism in young and middle-aged patients with femoral neck fracture. A prospective multicenter study on 185 patients
• One or more riskfactor for osteoporosis in the majority of young and middle-aged patients with femoral neck fractures irrespective of trauma mechanism
• Outcome and Quality of life after hip fracture in diabetic vs non diabetic patients
• Gender differences in comorbidity and complications after hip fracture - a prospective cohort study of 1,955 Swedish patients
• Empowerment - a way of reducing length of stay and mortality in patients with hip fracture?
• Effects of empowerment 4 months after a hip fracture on comorbidity and mortality
• Empowerment - aspects of function and quality of life in patients with hip fracture
• Empowerment as treatment after a hip fracture
• Gait ability and function one year after trochanteric fracture - a retrospective exploratory cohort study
• Subtrochanteric fractures - differences comparing patients with pathological an non-pathological fracture
• Validation of POSSUM audit system in orthopedic patients
• One year follow up of surgucally treated ankle fratures; regression analysis
• Epidemiology of ankle fractures in Sweden 1987-2004
• Long and short term outcome of surgically treated ankle fractures in Sweden 1987-1997
• Epidemiology in thoracolumbar fracture
• 3D datortomografi vid TSF
• Datortomografi vid frakturläkning
• HOLLT Prospektiv Internationell Multicenter
• Svåra underbensfrakturer
• Retrospective long term follow-up of traumatic dislocations of the patella in children
• Intra- and interexaminer reliability of two different measurements of knee function in children
• dGEMRIC examination of articular cartilage of the patella after non-operatively treated recurrent patellar dislocations in children
• Degeneration of patellar cartilage after surgical treatment of recurrent patellar dislocation in childhood, evaluation with dGEMRIC
• Healing of osteochondral fractures fixated with bio-degradable nails after acute patellar dislocation in childhood, examination with dGEMRIC
• Retroperitoneal blödning vid bäckenfrakturer
• Artroplastik efter acetabulärfrakturer
• Instabilitetsbedömning vid bäckenfrakturer med CT
• Gait ability and function one year after trochanteric fracture - a retrospective exploratory cohort study

Integrativ ortopedi

Forskningsledare Paul Ackermann

Universitetslektor/klinisk anställning

Paul Ackermann

Enhet:	Administration
E-post:	Paul.Ackermann@ki.se

STOP Leg Clots - nationell multicenterstudie

Pågående forskningsprojekt - Integrativ ortopedi

• Decreased levels of SP after denervation are correlated with reduced mechanical properties in healing Achilles tendon
• Neuronal pathways in tendon healing
• Inflammatoriska geners/molekylers mönster vid traumatisk ledskada, med fokus på ledhinna
• Immobilization Up-regulates Early Expression of Sensory Neuropeptides
• Impaired Expression of the Growth Associated Protein-43 in Peripheral Tissues of A Diabetic Animal Model-the Leptin Receptor Knockout Mice
• Diabetes Mellitus Impairs Proliferative Tendon Repair
• Diabetes Mellitus Hampers Nerve Growth Factor Receptor in Tendon Repair
• IGF1-R Downregulated in Diabetic Tendon Repair
• HA Gels for Delivery of SP in Tendon Repair
• Chemokine Expression In Tendon Repair
• Compression Therapy Promotes Tissue Perfusion And Gene Expression
• Intermittent Foot Compression under Plaster Cast for prevention of Venous Thromboembolism remains questionable
• Metabolic Activity in Early Human Achilles Tendon Repair Can Be Enhanced by Intermittent Pneumatic Compression
• Improved Functional Outcome After Compression Treatment During Tendon Immobilization
• Decreased Thrombosis Incidence Correlates to Improved Healing and Function After Immobilization
• Interleukin 6 is up-regulated by Intermittent Pneumatic Compression during Achilles Tendon Repair
• Stem cells in Achilles tendon repair
• Glutamate Receptors In Tendinopathic Patients
• Injection Of NMDA-Receptor Antagonists Inhibit Tendinopathic Pain
• Resistance exercise using flywheel technology promotes higher quadriceps activation

Artroplastik

Forskningsledare Per Wretenberg

Anknuten

Per Wretenberg

Enhet:	Ortopedi
E-post:	Per.Wretenberg@ki.se

Pågående forskningsprojekt - Artroplastik

• A cementless, modular hip revision arthroplasty used in primary total hip replacement
• Survival of uncemented acetabular monoblock cups in the Swedish Hip Arthroplasty Register
• Clinical and radiographic follow-up after total knee revision arthroplasty
• Complications in relation to surgical approach in hip arthroplasty
• Grade of radiographic osteoarthritis predicts relief of pain with movement
• 7 års-uppföljning MS30 RSA
• Lossningsdiagnostik av femurstamen med CT
• Slitagemätning av cuppar med CT- in vitrostudie av Morschecup
• Computed tomography analysis of radiostereometric data to determine flexion axes after total joint replacement: Application to the elbow joint
• Classification of periprostic osteolysis
• Does Anatomic positioning of the cup reduce wear rate?
• Ger slitage upphov till osteolys?
• Aktivitets score hos patienter med ocementerade kuppar
• Clinical review of wear of the polyethylene tibial insert and osteolysis associated with total knee replacement at the Massachusetts General Hospital (MGH)
• Validation of a new way to measure polyethylene wear in the hip by computerized tomography, a phantom study
• Develop and validate a model for measuring polyethylene thickness using a CT scanner and a coordinate measuring machine
• Koncentrationer av la och NSAID vid LIA för knäprotes kirurgi
• Koncentrationer av la och NSAID vid LIA för
• Incidence of early periprosthetic infection following THA
• LIA vs femoralis blockad vid knäprotes
• Tramadol does not prevent persistent pain after TKA
• Gaitdeviation index- metodutveckling
• Gaitdeviation index- Artros och RA

Tumör

Forskningsledare Henrik Bauer

Pågående forskningsprojekt - Tumör

• Kir beh av patol humerusfx
• Patologiska frakturer hos melanompat
• Surgery of skeletal metastases in patients with prostate cancer
• Subtrochantära patologiska frakturer
• Immunohistokemisk analys av skelettmetasaser
• Markers for prognosis,treatmentresponse and surgery margins in sarcoma
• Late effects of surgery and radiation i soft tissue sarcoma treatment
• Ewing sarcoma of the pelvis. Surgery and/or radiotherapy.
• The role of FDG-PET-DT in staging and evaluation of therapeutic response in bone sarcomas
• Ewing sarcoma of the spine. Surgery and/or radiotherapy.
• The role of fine needle aspiration in diagnosis of soft tissue tumors
• Skandinaviska sarkomgruppens register
• Utfall vid behandling av patienter med spinala metastaser
• Survival and function of non-operated patients with spinal cord compression due to metastatic disease
• Cytogenetisk analys av sarkom F Mertens
• Cytogenetisk analys av myxoida liposarkom
• Cytogenetisk analys av synoviala sarkom