Medicinsk inflammationsforskning – Rikard Holmdahls grupp

Vår forskning, under ledning av Rikard Holmdahl, syftar till att förstå grundläggande orsaker till komplexa inflammatoriska sjukdomar som autoimmuna sjukdomar och cancer. Vi försöker identifiera och funktionellt analysera de gener som styr autoimmuna sjukdomar, främst genom att använda djurmodeller där det är möjligt att identifiera genetiska orsaker till komplexa sjukdomar.

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Article: ADVANCED SCIENCE. 2024;11(23):e2401513
Human MHC Class II and Invariant Chain Knock-in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association
Romero-Castillo L; Li T; Do N-N; Sareila O; Xu B; Hennings V; Xu Z; Svensson C; Oliveira-Coelho A; Sener Z; Urbonaviciute V; Ekwall O; Burkhardt H; Holmdahl R
Review: ANNALS OF THE RHEUMATIC DISEASES. 2024;83(5):550-555
Shift in perspective: autoimmunity protecting against rheumatoid arthritis
He Y; Aoun M; Xu Z; Holmdahl R
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2023;220(11):e20230101
Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.
Aoun M; Coelho A; Krämer A; Saxena A; Sabatier P; Beusch CM; Lönnblom E; Geng M; Do N-N; Xu Z; Zhang J; He Y; Romero Castillo L; Abolhassani H; Xu B; Viljanen J; Rorbach J; Fernandez Lahore G; Gjertsson I; Kastbom A; Sjöwall C; Kihlberg J; Zubarev RA; Burkhardt H; Holmdahl R
Article: NATURE COMMUNICATIONS. 2023;14(1):5949
A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils
Xu Z; Xu B; Lundstrom SL; Moreno-Giro A; Zhao D; Martin M; Lonnblom E; Li Q; Kramer A; Ge C; Cheng L; Liang B; Tong D; Stawikowska R; Blom AM; Fields GB; Zubarev RA; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(7):1110-1119
Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis
Lonnblom E; Leu Agelii M; Sareila O; Cheng L; Xu B; Viljanen J; Hafstrom I; Andersson MLE; Bergstrom G; Ekwall A-KH; Rudin A; Kastbom A; Sjowall C; Jacobsson LTH; Kihlberg J; Gjertsson I; Holmdahl R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(25):e2218668120
Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis.
Urbonaviciute V; Romero-Castillo L; Xu B; Luo H; Schneider N; Weisse S; Do N-N; Oliveira-Coelho A; Fernandez Lahore G; Li T; Sabatier P; Beusch CM; Viljanen J; Zubarev RA; Kihlberg J; Bäcklund J; Burkhardt H; Holmdahl R
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(6):799-808
Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage
Li T; Ge C; Kramer A; Sareila O; Agelii ML; Johansson L; Forslind K; Lonnblom E; Yang M; Xu B; Li Q; Cheng L; Bergstrom G; Fernandez G; Kastbom A; Rantapaa-Dahlqvist S; Gjertsson I; Holmdahl R
Article: NATURE COMMUNICATIONS. 2023;14(1):691
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
He Y; Ge C; Moreno-Giro A; Xu B; Beusch CM; Sandor K; Su J; Cheng L; Lonnblom E; Lundqvist C; Slot LM; Tong D; Urbonaviciute V; Liang B; Li T; Lahore GF; Aoun M; Malmstrom V; Rispens T; Ernfors P; Svensson CI; Scherer HU; Toes REM; Gjertsson I; Ekwall O; Zubarev RA; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(6):961-971
Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis
Ge C; Tong D; Loennblom E; Liang B; Cai W; Fahlquist-Hagert C; Li T; Kastbom A; Gjertsson I; Dobritzsch D; Holmdahl R
Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(4):480-489
Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor
Ge C; Weisse S; Xu B; Dobritzsch D; Viljanen J; Kihlberg J; Do N-N; Schneider N; Lanig H; Holmdahl R; Burkhardt H

Medicinsk inflammationsforskning – Rikard Holmdahls grupp

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