Nya riktade cancerbehandlingar för att övervinna läkemedelsresistens – Katja Pokrovskaja Tamms team

Publikationer

Utvalda publikationer

• Article: MOLECULAR ONCOLOGY. 2024;18(8):1904-1922

  Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy

  Yu Y; Bogdan M; Noman MZ; Parpal S; Bartolini E; Van Moer K; Kleinendorst SC; Saether KB; Tresaugues L; Silvander C; Lindstroem J; Simeon J; Timson MJ; Al-Hashimi H; Smith BD; Flynn DL; Alexeyenko A; Viklund J; Andersson M; Martinsson J; Tamm KP; De Milito A; Janji B
• Article: SCIENTIFIC REPORTS. 2024;14(1):4000

  Targeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia

  Bwanika HC; Leo IR; Struyf N; Talanti A; Aswad L; Konnur A; Bjoerklund A-C; Heyman M; Rassidakis G; Erkers T; Seashore-Ludlow B; Jafari R; Pokrovskaja Tamm K
• Article: NATURE COMMUNICATIONS. 2022;13(1):1691

  Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines

  Leo IR; Aswad L; Stahl M; Kunold E; Post F; Erkers T; Struyf N; Mermelekas G; Joshi RN; Gracia-Villacampa E; Ostling P; Kallioniemi OP; Tamm KP; Siavelis I; Lehtio J; Vesterlund M; Jafari R
• Article: SCIENTIFIC REPORTS. 2021;11(1):11023

  PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma

  Vidarsdottir L; Azimi A; Das I; Sigvaldadottir I; Rahmanto AS; Petri A; Kauppinen S; Ingvar C; Jonsson G; Olsson H; Stolt MF; Tuominen R; Sangfelt O; Tamm KP; Hansson J; Grander D; Brage SE; Johnsson P
• Article: MELANOMA RESEARCH. 2020;30(5):443-454

  Silencing of CEBPB-AS1 modulates CEBPB expression and resensitizes BRAF-inhibitor resistant melanoma cells to vemurafenib

  Vidarsdottir L; Fernandes RV; Zachariadis V; Das I; Edsbacker E; Sigvaldadottir I; Azimi A; Hoiom V; Hansson J; Grander D; Egyhazi Brage S; Pokrovskaja Tamm K
• Article: SCIENCE ADVANCES. 2020;6(12):eaax7945

  Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death

  Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grander D; Arner ESJ; Tamm KP; Page BDG
• Article: SCIENTIFIC REPORTS. 2019;9(1):536

  STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes

  Edsbacker E; Serviss JT; Kolosenko I; Palm-Apergi C; De Milito A; Tamm KP
• Article: CANCER LETTERS. 2018;435:32-43

  Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

  Dyczynski M; Yu Y; Otrocka M; Parpal S; Braga T; Henley AB; Zazzi H; Lerner M; Wennerberg K; Viklund J; Martinsson J; Grander D; De Milito A; Tamm KP
• Article: CELL DEATH & DISEASE. 2018;9(9):846

  Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment

  Dyczynski M; Vesterlund M; Bjorklund A-C; Zachariadis V; Janssen J; Gallart-Ayala H; Daskalaki E; Wheelock CE; Lehtio J; Grander D; Tamm KP; Nilsson R
• Article: PLOS ONE. 2017;12(6):e0178844

  Identification of novel small molecules that inhibit STAT3-dependent transcription and function

  Kolosenko I; Yu Y; Busker S; Dyczynski M; Liu J; Haraldsson M; Apergi CP; Helleday T; Tamm KP; Page BDG; Grander D
• Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(4):e51-e61

  Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

  Kolosenko I; Fryknas M; Forsberg S; Johnsson P; Cheon H; Holvey-Bates EG; Edsbacker E; Pellegrini P; Rassoolzadeh H; Brnjic S; Larsson R; Stark GR; Grander D; Linder S; Tamm KP; De Milito A
• Article: EXPERIMENTAL CELL RESEARCH. 2013;319(5):600-611

  An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma

  Lin H; Kolosenko I; Bjorklund A-C; Protsyuk D; Osterborg A; Grander D; Tamm KP
• Article: BLOOD CANCER JOURNAL. 2011;1(7):e31

  Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells

  Buentke E; Nordstrom A; Lin H; Bjorklund A-C; Laane E; Harada M; Lu L; Tegnebratt T; Stone-Elander S; Heyman M; Soderhall S; Porwit A; Ostenson C-G; Shoshan M; Tamm KP; Grander D
• Article: EXPERIMENTAL CELL RESEARCH. 2011;317(1):9-19

  Activation of STAT1 is required for interferon-alpha-mediated cell death

  Arulampalam V; Kolosenko I; Hjortsbert L; Bjorklund A-C; Grander D; Tamm KP
• Article: CELL DEATH AND DIFFERENTIATION. 2009;16(7):1018-1029

  Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

  Laane E; Tamm KP; Buentke E; Ito K; Kharaziha P; Oscarsson J; Corcoran M; Bjorklund A-C; Hultenby K; Lundin J; Heyman M; Soderhall S; Mazur J; Porwit A; Pandolfi PP; Zhivotovsky B; Panaretakis T; Grander D

Medarbetare och kontakt

Gruppledare

• 

  Katja Pokrovskaja Tamm

  Projektsamordnare | Docent

  E-postadress katja.pokrovskaja@ki.se

Alla medarbetare i gruppen

• 

  Katja Pokrovskaja Tamm

  Projektsamordnare | Docent

  E-postadress katja.pokrovskaja@ki.se

Besöksadress

Karolinska Institute, Oncology-Pathology, Akademiska stråket 1, BioClinicum J6:14, Stockholm, 17164, Sweden