Nukleotidmetabolism och molekylära terapeutiska medel – Sean Rudds forskargrupp

Publikationer

Utvalda publikationer

• Preprint: BIORXIV. 2023

  Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1viaa comprehensive screening funnel

  Zhang SM; Paulin CBJ; Michel M; Marttila P; Yagüe-Capilla M; Bwanika HC; Shu H; Vekatram RP; Wiita E; Jemth A-S; Almlöf I; Loseva O; Ortis F; Dirks C; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Strömberg K; Homan E; Scobie M; Lundbäck T; Helleday T; Rudd S
• Review: MOLECULAR ONCOLOGY. 2022;16(21):3792-3810

  Targeting the DNA damage response and repair in cancer through nucleotide metabolism

  Helleday T; Rudd SG
• Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(170)

  A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1

  Yague-Capilla M; Rudd SG
• Article: BMC RESEARCH NOTES. 2021;14(1):27

  Drug synergy scoring using minimal dose response matrices

  Makela P; Zhang SM; Rudd SG
• Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419

  Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy

  Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
• Review: CANCERS. 2018;10(7):E240-240

  Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

  Tsesmetzis N; Paulin CBJ; Rudd SG; Herold N
• Article: NATURE MEDICINE. 2017;23(2):256-263

  Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies

  Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Paget BDG; Calderon-Montano JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Hoglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grander D; Lundback T; Kogner P; Henter J-I; Helleday T; Schaller T

Medarbetare och kontakt

Gruppledare

• 

  Sean Rudd

  Senior Forskare

  E-postadress sean.rudd@ki.se

Alla medarbetare i gruppen

• 

  Christopher Dirks

  Doktorand

  E-postadress christopher.dirks@ki.se
• Jelle Dylus

  E-postadress jelle.dylus@ki.se
• 

  Femke Hormann

  Postdoktor

  E-postadress femke.hormann@ki.se
• 

  Sean Rudd

  Senior Forskare

  E-postadress sean.rudd@ki.se
• 

  Si Min Zhang

  Forskningsspecialist

  E-postadress si.zhang@ki.se