Strukturell och biofysikalisk immunologi – Forskargrupp Adnane Achour

Article: ANTIOXIDANTS. 2021;10(7):1094

A Novel mRNA-Mediated and MicroRNA-Guided Approach to Specifically Eradicate Drug-Resistant Hepatocellular Carcinoma Cell Lines by Se-Methylselenocysteine.

Selvam AK; Jawad R; Gramignoli R; Achour A; Salter H; Björnstedt M

Article: ACS NANO. 2021;15(4):7500-7512

Clustering of Major Histocompatibility Complex-Class I Molecules in Healthy and Cancer Colon Cells Revealed from Their Nanomechanical Properties.

Moretti M; La Rocca R; Perrone Donnorso M; Torre B; Canale C; Malerba M; Das G; Sottile R; Garofalo C; Achour A; Kärre K; Carbone E; Di Fabrizio E

Article: SCIENTIFIC REPORTS. 2020;10(1):22455

The serine protease HtrA plays a key role in heat-induced dispersal of pneumococcal biofilms.

Chao Y; Bergenfelz C; Sun R; Han X; Achour A; Hakansson AP

Article: BIOMOLECULAR NMR ASSIGNMENTS. 2020;14(2):195-200

Assigned NMR backbone resonances of the ligand-binding region domain of the pneumococcal serine-rich repeat protein (PsrP-BR) reveal a rigid monomer in solution.

Schulte T; Sala BM; Nilvebrant J; Nygren P-Å; Achour A; Shernyukov A; Agback T; Agback P

Article: NATURE COMMUNICATIONS. 2020;11(1):4420

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.

Hanke L; Vidakovics Perez L; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Karlsson Hedestam GB; Hällberg BM; Murrell B; McInerney GM

Article: PLOS PATHOGENS. 2020;16(9):e1008855

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.

De Meo S; Dell'Oste V; Molfetta R; Tassinari V; Lotti LV; Vespa S; Pignoloni B; Covino DA; Fantuzzi L; Bona R; Zingoni A; Nardone I; Biolatti M; Coscia A; Paolini R; Benkirane M; Edfors F; Sandalova T; Achour A; Hiscott J; Landolfo S; Santoni A; Cerboni C

Article: BMC IMMUNOLOGY. 2020;21(1):27

Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis.

Gerstner C; Turcinov S; Hensvold AH; Chemin K; Uchtenhagen H; Ramwadhdoebe TH; Dubnovitsky A; Kozhukh G; Rönnblom L; Kwok WW; Achour A; Catrina AI; van Baarsen LGM; Malmström V

Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(9):E3235-3235

Glycosylation Tunes Neuroserpin Physiological and Pathological Properties.

Visentin C; Broggini L; Sala BM; Russo R; Barbiroli A; Santambrogio C; Nonnis S; Dubnovitsky A; Bolognesi M; Miranda E; Achour A; Ricagno S

Article: PLOS PATHOGENS. 2020;16(5):e1008244

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination.

Duru AD; Sun R; Allerbring EB; Chadderton J; Kadri N; Han X; Peqini K; Uchtenhagen H; Madhurantakam C; Pellegrino S; Sandalova T; Nygren P-Å; Turner SJ; Achour A

Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2020;50(4):494-504

IL-15 and CD155 expression regulate LAT expression in murine DNAM1+ NK cells, enhancing their effectors functions.

Luu TT; Wagner AK; Schmied L; Meinke S; Freund JE; Kambayashi T; Ravens I; Achour A; Bernhardt G; Chambers BJ; Höglund P; Kadri N

Article: FEBS JOURNAL. 2020;287(3):546-560

Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity.

Achour A; Broggini L; Han X; Sun R; Santambrogio C; Buratto J; Visentin C; Barbiroli A; De Luca CMG; Sormanni P; Moda F; De Simone A; Sandalova T; Grandori R; Camilloni C; Ricagno S

Article: FRONTIERS IN IMMUNOLOGY. 2020;11:437

Interaction With 14-3-3 Correlates With Inactivation of the RIG-I Signalosome by Herpesvirus Ubiquitin Deconjugases.

Gupta S; Ylä-Anttila P; Sandalova T; Achour A; Masucci MG

Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(1):179-191

Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+ T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies.

Galindo-Feria AS; Albrecht I; Fernandes-Cerqueira C; Notarnicola A; James EA; Herrath J; Dastmalchi M; Sandalova T; Rönnblom L; Jakobsson P-J; Fathi M; Achour A; Grunewald J; Malmström V; Lundberg IE

Article: PLOS PATHOGENS. 2019;15(11):e1008146

14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases.

Gupta S; Ylä-Anttila P; Sandalova T; Sun R; Achour A; Masucci MG

Article: JCI INSIGHT. 2019;5(9):126492

B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets.

Sundling C; Rönnberg C; Yman V; Asghar M; Jahnmatz P; Lakshmikanth T; Chen Y; Mikes J; Forsell MN; Sondén K; Achour A; Brodin P; Persson KE; Färnert A

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(11):5055-5060

Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin.

Hafstrand I; Sayitoglu EC; Apavaloaei A; Josey BJ; Sun R; Han X; Pellegrino S; Ozkazanc D; Potens R; Janssen L; Nilvebrant J; Nygren P-Å; Sandalova T; Springer S; Georgoudaki A-M; Duru AD; Achour A

Article: EBIOMEDICINE. 2019;40:517-527

B cell alterations during BAFF inhibition with belimumab in SLE.

Ramsköld D; Parodis I; Lakshmikanth T; Sippl N; Khademi M; Chen Y; Zickert A; Mikeš J; Achour A; Amara K; Piehl F; Brodin P; Gunnarsson I; Malmström V

Article: AUTOIMMUNITY. 2019;52(1):1-11

Individual and stable autoantibody repertoires in healthy individuals.

Neiman M; Hellström C; Just D; Mattsson C; Fagerberg L; Schuppe-Koistinen I; Gummesson A; Bergström G; Kallioniemi O; Achour A; Sallinen R; Uhlén M; Nilsson P

Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;89(1):e12732

Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis.

Tang Q; Ramsköld D; Krystufkova O; Mann HF; Wick C; Dastmalchi M; Lakshmikanth T; Chen Y; Mikes J; Alexanderson H; Achour A; Brodin P; Vencovsky J; Lundberg IE; Malmström V

Article: NATURE MICROBIOLOGY. 2019;4(1):62-70

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival.

Subramanian K; Neill DR; Malak HA; Spelmink L; Khandaker S; Dalla Libera Marchiori G; Dearing E; Kirby A; Yang M; Achour A; Nilvebrant J; Nygren P-Å; Plant L; Kadioglu A; Henriques-Normark B

Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2249

The Complement System Is Essential for the Phagocytosis of Mesenchymal Stromal Cells by Monocytes.

Gavin C; Meinke S; Heldring N; Heck KA; Achour A; Iacobaeus E; Höglund P; Le Blanc K; Kadri N

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