Tobias Allanders grupp

Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(2):110-130

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding.

Massó-Vallés D; Beaulieu M-E; Jauset T; Giuntini F; Zacarías-Fluck MF; Foradada L; Martínez-Martín S; Serrano E; Martín-Fernández G; Casacuberta-Serra S; Castillo Cano V; Kaur J; López-Estévez S; Morcillo MÁ; Alzrigat M; Mahmoud L; Luque-García A; Escorihuela M; Guzman M; Arribas J; Serra V; Larsson L-G; Whitfield JR; Soucek L

Journal article: INVESTIGATIONAL NEW DRUGS. 2021;39(2):587-594

The novel low molecular weight MYC antagonist MYCMI-6 inhibits proliferation and induces apoptosis in breast cancer cells.

AlSultan D; Kavanagh E; O'Grady S; Eustace AJ; Castell A; Larsson L-G; Crown J; Madden SF; Duffy MJ

Article: CELL CYCLE. 2021;20(1):23-38

Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence.

Bazzar W; Bocci M; Hejll E; Högqvist Tabor V; Hydbring P; Grandien A; Alzrigat M; Larsson L-G

Article: METHODS IN MOLECULAR BIOLOGY. 2021;2318:241-254

Methods to Study Myc-Regulated Cellular Senescence: An Update.

Zhang F; Bazzar W; Alzrigat M; Larsson L-G

Article: ELIFE. 2020;9:e57894

PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.

Brunner A; Suryo Rahmanto A; Johansson H; Franco M; Viiliäinen J; Gazi M; Frings O; Fredlund E; Spruck C; Lehtiö J; Rantala JK; Larsson L-G; Sangfelt O

Article: SCIENTIFIC REPORTS. 2018;8(1):10064

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation.

Castell A; Yan Q; Fawkner K; Hydbring P; Zhang F; Verschut V; Franco M; Zakaria SM; Bazzar W; Goodwin J; Zinzalla G; Larsson L-G

Review: GENES. 2017;8(7):E174-174

MYC Modulation around the CDK2/p27/SKP2 Axis.

Hydbring P; Castell A; Larsson L-G

Article: ONCOTARGET. 2016;7(3):2837-2854

Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation.

Bahram F; Hydbring P; Tronnersjö S; Zakaria SM; Frings O; Fahlén S; Nilsson H; Goodwin J; von der Lehr N; Su Y; Lüscher B; Castell A; Larsson L-G

Editorial comment: CANCER DISCOVERY. 2015;5(7):701-703

Targeting MYC Translation in Colorectal Cancer.

Castell A; Larsson L-G

Article: CANCER RESEARCH. 2014;74(16):4222-4229

MYC synergizes with activated BRAFV600E in mouse lung tumor development by suppressing senescence.

Tabor V; Bocci M; Alikhani N; Kuiper R; Larsson L-G

Article: EMBO MOLECULAR MEDICINE. 2013;5(7):1067-1086

CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.

Cepeda D; Ng H-F; Sharifi HR; Mahmoudi S; Cerrato VS; Fredlund E; Magnusson K; Nilsson H; Malyukova A; Rantala J; Klevebring D; Viñals F; Bhaskaran N; Zakaria SM; Rahmanto AS; Grotegut S; Nielsen ML; Szigyarto CA-K; Sun D; Lerner M; Navani S; Widschwendter M; Uhlén M; Jirström K; Pontén F; Wohlschlegel J; Grandér D; Spruck C; Larsson L-G; Sangfelt O

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(4):E187-E196

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop.

Menssen A; Hydbring P; Kapelle K; Vervoorts J; Diebold J; Lüscher B; Larsson L-G; Hermeking H

Review: SEMINARS IN CANCER BIOLOGY. 2011;21(6):367-376

Oncogene- and tumor suppressor gene-mediated suppression of cellular senescence.

Larsson L-G

Review: CANCER RESEARCH. 2010;70(17):6687-6691

Tipping the balance: Cdk2 enables Myc to suppress senescence.

Hydbring P; Larsson L-G

Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1429-1437

The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy.

Larsson L-G; Henriksson MA

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(1):58-63

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.

Hydbring P; Bahram F; Su Y; Tronnersjö S; Högstrand K; von der Lehr N; Sharifi HR; Lilischkis R; Hein N; Wu S; Vervoorts J; Henriksson M; Grandien A; Lüscher B; Larsson L-G

Article: NATURE CELL BIOLOGY. 2010;12(1):54-59

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

Campaner S; Doni M; Hydbring P; Verrecchia A; Bianchi L; Sardella D; Schleker T; Perna D; Tronnersjö S; Murga M; Fernandez-Capetillo O; Barbacid M; Larsson L-G; Amati B

Article: NATURE METHODS. 2006;3(12):995-1000

Direct observation of individual endogenous protein complexes in situ by proximity ligation.

Söderberg O; Gullberg M; Jarvius M; Ridderstråle K; Leuchowius K-J; Jarvius J; Wester K; Hydbring P; Bahram F; Larsson L-G; Landegren U

Article: NATURE CELL BIOLOGY. 2005;7(3):303-310

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

Arabi A; Wu S; Ridderstråle K; Bierhoff H; Shiue C; Fatyol K; Fahlén S; Hydbring P; Söderberg O; Grummt I; Larsson L-G; Wright APH

Article: MOLECULAR CELL. 2003;11(5):1189-1200

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

von der Lehr N; Johansson S; Wu S; Bahram F; Castell A; Cetinkaya C; Hydbring P; Weidung I; Nakayama K; Nakayama KI; Söderberg O; Kerppola TK; Larsson L-G

Article: BLOOD. 2000;95(6):2104-2110

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover.

Bahram F; von der Lehr N; Cetinkaya C; Larsson LG

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