Utveckling av små molekyler som återställer tumörhämmande funktioner hos p53 – Galina Selivanovas grupp

Vår forskning fokuserar på utvecklingen av små molekyler som reaktivera tumörsuppressions funktionerna hos p53, antingen genom att åteställer mutant p53 för att rädda dess aktivitet eller genom att förhindra proteasom nedbrytning av p53 i tumörer med icke-muterad p53.

En del av Institutionen för mikrobiologi, tumör- och cellbiologi

Publikationer
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Publikationer

Utvalda publikationer

Conference publication: CANCER SCIENCE. 2023;114:249
Pharmacological activation of p53 triggers viral mimicry response thereby promoting anti-tumor immunity
Selivanova G; Zhou X; Singh M; Sanz G; Guerlavais V; Carvajal LA; Aivado M; Annis A; Zhan Y; Oliveira M; Westerberg L; Johnsen JI
Article: BRITISH JOURNAL OF CANCER. 2022;127(11):2060-2071
Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246
Zhou X; Santos GS; Zhan Y; Oliveira MMS; Rezaei S; Singh M; Peuget S; Westerberg LS; Johnsen JI; Selivanova G
Article: MOLECULAR CANCER THERAPEUTICS. 2022;21(10):1524-1534
Decreased DNA Damage and Improved p53 Specificity of RITA Analogs
Zhan Y; Zhou X; Peuget S; Singh M; Peyser BD; Fan Z; Selivanova G
Article: ONCOGENE. 2022;41(15):2173-2186
Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization
Aschtgen M-S; Fragkoulis K; Sanz G; Normark S; Selivanova G; Henriques-Normark B; Peuget S
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:823195
Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule
Grinkevich VV; Vema A; Fawkner K; Issaeva N; Andreotti V; Dickinson ER; Hedstrom E; Spinnler C; Inga A; Larsson L-G; Karlen A; Wilhelm M; Barran PE; Okorokov AL; Selivanova G; Zawacka-Pankau JE
Editorial comment: CANCERS. 2021;13(19):4850
p53-Dependent Repression: DREAM or Reality?
Peuget S; Selivanova G
Article: ISCIENCE. 2020;23(12):101785
Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin
Guerrero-Garzon JF; Madland E; Zehl M; Singh M; Rezaei S; Aachmann FL; Courtade G; Urban E; Rueckert C; Busche T; Kalinowski J; Cao Y-R; Jiang Y; Jiang C-L; Selivanova G; Zotchev SB
Article: BREAST CANCER RESEARCH. 2020;22(1):80
Identification and targeting of selective vulnerability rendered by tamoxifen resistance
Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arner ESJ; Hartman J; Selivanova G
Article: CANCER RESEARCH. 2020;80(7):1538-1550
Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: JOURNAL OF CLINICAL MEDICINE. 2020;9(2):E598-598
p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture
Rangel-Pozzo A; Booth S; Yu PLI; Singh M; Selivanova G; Mai S
Article: SCIENTIFIC REPORTS. 2020;10(1):1049
Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes
Zhu J; Singh M; Selivanova G; Peuget S
Article: HAEMATOLOGICA. 2020;105(1):170-181
Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia
Demir S; Boldrin E; Sun Q; Hampp S; Tausch E; Eckert C; Ebinger M; Handgretinger R; te Kronnie G; Wiesmueller L; Stilgenbauer S; Selivanova G; Debatin K-M; Meyer LH
Article: CELL DEATH AND DISEASE. 2019;10(11):845
RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity
Ristau J; van Hoef V; Peuget S; Zhu J; Guan B-J; Liang S; Hatzoglou M; Topisirovic I; Selivanova G; Larsson O
Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(7):586-599
Inhibition of p53 inhibitors: progress, challenges and perspectives
Sanz G; Singh M; Peuget S; Selivanova G

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Gruppledare

Galina Selivanova
Professor | Docent
Telefon +46852486302
E-postadress galina.selivanova@ki.se

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Knotha Mudalige Diyoly Ayona Appuhamy
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Gunnar Bjursell
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Liudmila Matskova
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Roland Möllby
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Imran Nawaz
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Iurii Petrov
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Sylvain Peuget
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Eric Scarfone
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E-postadress eric.scarfone@ki.se
Galina Selivanova
Professor | Docent
Telefon +46852486302
E-postadress galina.selivanova@ki.se
John Sennett
Informationsadministratör
Telefon +46852486248
E-postadress john.sennett@ki.se
Jie-Zhi Zou
Senior Lab Manager
E-postadress jiezhi.zou@ki.se