Utveckling av små molekyler som återställer tumörhämmande funktioner hos p53 – Galina Selivanovas grupp

Vår forskning fokuserar på utvecklingen av små molekyler som reaktivera tumörsuppressions funktionerna hos p53, antingen genom att åteställer mutant p53 för att rädda dess aktivitet eller genom att förhindra proteasom nedbrytning av p53 i tumörer med icke-muterad p53.

En del av Institutionen för mikrobiologi, tumör- och cellbiologi

Publikationer
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Publikationer

Utvalda publikationer

Conference publication: CANCER SCIENCE. 2023;114:249

Pharmacological activation of p53 triggers viral mimicry response thereby promoting anti-tumor immunity

Selivanova G; Zhou X; Singh M; Sanz G; Guerlavais V; Carvajal LA; Aivado M; Annis A; Zhan Y; Oliveira M; Westerberg L; Johnsen JI
Article: BRITISH JOURNAL OF CANCER. 2022;127(11):2060-2071

Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246.

Zhou X; Santos GS; Zhan Y; Oliveira MMS; Rezaei S; Singh M; Peuget S; Westerberg LS; Johnsen JI; Selivanova G
Article: MOLECULAR CANCER THERAPEUTICS. 2022;21(10):1524-1534

Decreased DNA Damage and Improved p53 Specificity of RITA Analogs.

Zhan Y; Zhou X; Peuget S; Singh M; Peyser BD; Fan Z; Selivanova G
Article: ONCOGENE. 2022;41(15):2173-2186

Enterobacteria impair host p53 tumor suppressor activity through mRNA destabilization.

Aschtgen M-S; Fragkoulis K; Sanz G; Normark S; Selivanova G; Henriques-Normark B; Peuget S
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:823195

Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule.

Grinkevich VV; Vema A; Fawkner K; Issaeva N; Andreotti V; Dickinson ER; Hedström E; Spinnler C; Inga A; Larsson L-G; Karlén A; Wilhelm M; Barran PE; Okorokov AL; Selivanova G; Zawacka-Pankau JE
Editorial comment: CANCERS. 2021;13(19):4850

p53-Dependent Repression: DREAM or Reality?

Peuget S; Selivanova G
Article: ISCIENCE. 2020;23(12):101785

Class IV Lasso Peptides Synergistically Induce Proliferation of Cancer Cells and Sensitize Them to Doxorubicin.

Guerrero-Garzón JF; Madland E; Zehl M; Singh M; Rezaei S; Aachmann FL; Courtade G; Urban E; Rückert C; Busche T; Kalinowski J; Cao Y-R; Jiang Y; Jiang C-L; Selivanova G; Zotchev SB
Article: BREAST CANCER RESEARCH. 2020;22(1):80

Identification and targeting of selective vulnerability rendered by tamoxifen resistance.

Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arnér ESJ; Hartman J; Selivanova G
Article: CANCER RESEARCH. 2020;80(7):1538-1550

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds.

Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindström MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: JOURNAL OF CLINICAL MEDICINE. 2020;9(2):E598-598

p53 CRISPR Deletion Affects DNA Structure and Nuclear Architecture.

Rangel-Pozzo A; Booth S; Yu PLI; Singh M; Selivanova G; Mai S
Article: SCIENTIFIC REPORTS. 2020;10(1):1049

Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes.

Zhu J; Singh M; Selivanova G; Peuget S
Article: HAEMATOLOGICA. 2020;105(1):170-181

Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia.

Demir S; Boldrin E; Sun Q; Hampp S; Tausch E; Eckert C; Ebinger M; Handgretinger R; Kronnie GT; Wiesmüller L; Stilgenbauer S; Selivanova G; Debatin K-M; Meyer LH
Article: CELL DEATH & DISEASE. 2019;10(11):845

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity.

Ristau J; van Hoef V; Peuget S; Zhu J; Guan B-J; Liang S; Hatzoglou M; Topisirovic I; Selivanova G; Larsson O
Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(7):586-599

Inhibition of p53 inhibitors: progress, challenges and perspectives.

Sanz G; Singh M; Peuget S; Selivanova G

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Gruppledare

Galina Selivanova
Professor | Docent

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Diyoly Ayona Appuhamy
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Eric Scarfone
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Galina Selivanova
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Jie-Zhi Zou
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