Adnane Achour

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: COMMUNICATIONS BIOLOGY. 2024;7(1):868
Insights into mechanisms of MALT1 allostery from NMR and AlphaFold dynamic analyses
Wallerstein J; Han X; Levkovets M; Lesovoy D; Malmodin D; Mirabello C; Wallner B; Sun R; Sandalova T; Agback P; Karlsson G; Achour A; Agback T; Orekhov V
Journal article: VACCINES. 2024;12(4):357
Long-Term Survival and Immune Response Dynamics in Melanoma Patients Undergoing TAPCells-Based Vaccination Therapy.
Tittarelli A; Pereda C; Gleisner MA; López MN; Flores I; Tempio F; Lladser A; Achour A; González FE; Durán-Aniotz C; Miranda JP; Larrondo M; Salazar-Onfray F
Journal article: BIOPHYSICAL JOURNAL. 2024;123(3):21a-22a
The biophysical landscape of reconstituted immune synapses
Ragaller F; Sych T; Andronico L; Achour A; Sezgin E
Article: VACCINES. 2024;12(4):357
Long-Term Survival and Immune Response Dynamics in Melanoma Patients Undergoing TAPCells-Based Vaccination Therapy
Tittarelli A; Pereda C; Gleisner MA; Lopez MN; Flores I; Tempio F; Lladser A; Achour A; Gonzalez FE; Duran-Aniotz C; Miranda JP; Larrondo M; Salazar-Onfray F
Article: CRYSTALS. 2024;14(5):441
High Resolution Crystal Structure of the Pyruvate Kinase Tetramer in Complex with the Allosteric Activator Mitapivat/AG-348
Han X; Sandalova T; Zhang C; Mardinoglu A; Achour A; Sun R
Article: CELL REPORTS. 2023;42(12):113516
The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent
Middelburg J; Ghaffari S; Schoufour TAW; Sluijter M; Schaap G; Goynuk B; Sala BM; Al-Tamimi L; Scheeren F; Franken KLMC; Akkermans JJLL; Cabukusta B; Joosten SA; Derksen I; Neefjes J; van der Burg SH; Achour A; Wijdeven RHM; Weidanz J; van Hall T
Article: COMMUNICATIONS BIOLOGY. 2023;6(1):1193
Combined NMR and molecular dynamics conformational filter identifies unambiguously dynamic ensembles of Dengue protease NS2B/NS3pro
Agback T; Lesovoy D; Han X; Lomzov A; Sun R; Sandalova T; Orekhov VY; Achour A; Agback P
Article: BIOINFORMATICS. 2023;39(11):btad666
Open MoA: revealing the mechanism of action (MoA) based on network topology and hierarchy
Liao X; Ozcan M; Shi M; Kim W; Jin H; Li X; Turkez H; Achour A; Uhlen M; Mardinoglu A; Zhang C
Article: CHEMICAL COMMUNICATIONS. 2023;59(36):5475-5478
Resolution enhancement of NMR by decoupling with the low-rank Hankel model
Qiu T; Jahangiri A; Han X; Lesovoy D; Agback T; Agback P; Achour A; Qu X; Orekhov V
Article: OPEN BIOLOGY. 2023;13(5):220369
Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH
Schulte T; Panas MD; Han X; Williams L; Kedersha N; Fleck JS; Tan TJC; Dopico XC; Olsson A; Morro AM; Hanke L; Nilvebrant J; Giang KA; Nygren P-A; Anderson P; Achour A; McInerney GM
Article: JOURNAL OF MAGNETIC RESONANCE. 2023;346:107342
NMR spectrum reconstruction as a pattern recognition problem
Jahangiri A; Han X; Lesovoy D; Agback T; Agback P; Achour A; Orekhov V
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1230718
Non-classical HLA-E restricted CMV 15-mer peptides are recognized by adaptive NK cells and induce memory responses
Almazan NM; Sala BM; Sandalova T; Sun Y; Resink T; Cichocki F; Soderberg-Naucler C; Miller JS; Achour A; Sarhan D
Article: ISCIENCE. 2022;25(10):105137
PD-1 expression on mouse intratumoral NK cells and its effects on NK cell phenotype
Wagner AK; Kadri N; Tibbitt C; van de Ven K; Bagawath-Singh S; Oliinyk D; LeGresley E; Campbell N; Trittel S; Riese P; Ribacke U; Sandalova T; Achour A; Karre K; Chambers BJ
Article: BIOMOLECULAR NMR ASSIGNMENTS. 2022;16(2):363-371
Assignment of IVL-Methyl side chain of the ligand-free monomeric human MALT1 paracaspase-IgL₃ domain in solution
Han X; Levkovets M; Lesovoy D; Sun R; Wallerstein J; Sandalova T; Agback T; Achour A; Agback P; Orekhov VY
Article: BIOMOLECULAR NMR ASSIGNMENTS. 2022;16(1):135-145
H-1, C-13 and N-15 resonance assignment of backbone and IVL-methyl side chain of the S135A mutant NS3pro/NS2B protein of Dengue II virus reveals unique secondary structure features in solution
Agback P; Lesovoy DM; Han X; Sun R; Sandalova T; Agback T; Achour A; Orekhov VY
Article: ACS OMEGA. 2022;7(11):9622-9635
L- to D-Amino Acid Substitution in the Immunodominant LCMV-Derived Epitope gp33 Highlights the Sensitivity of the TCR Recognition Mechanism for the MHC/Peptide Structure and Dynamics
Ballabio F; Broggini L; Paissoni C; Han X; Peqini K; Sala BM; Sun R; Sandalova T; Barbiroli A; Achour A; Pellegrino S; Ricagno S; Camilloni C
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:854312
FOXO1 and FOXO3 Cooperatively Regulate Innate Lymphoid Cell Development
Luu TT; Sondergaard JN; Pena-Perez L; Kharazi S; Krstic A; Meinke S; Schmied L; Frengen N; Heshmati Y; Kierczak M; Bouderlique T; Wagner AK; Gustafsson C; Chambers BJ; Achour A; Kutter C; Hoglund P; Mansson R; Kadri N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2100687118
A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.
Landegren N; Ishii N; Aranda-Guillén M; Gunnarsson HI; Sardh F; Hallgren Å; Ståhle M; Hagforsen E; Bradley M; Edqvist P-HD; Pontén F; Mäkitie O; Eidsmo L; Norlén L; Achour A; Dahlbom I; Korponay-Szabó I; Agardh D; Alimohammadi M; Eriksson D; Hashimoto T; Kämpe O
Article: ANTIOXIDANTS. 2021;10(7):1094
A Novel mRNA-Mediated and MicroRNA-Guided Approach to Specifically Eradicate Drug-Resistant Hepatocellular Carcinoma Cell Lines by Se-Methylselenocysteine
Selvam AK; Jawad R; Gramignoli R; Achour A; Salter H; Bjornstedt M
Journal article: CANCER RESEARCH. 2021;81(13_Supplement):1349
Abstract 1349: Application of the DARPin® technology for specific targeting of tumor-associated MHC class I:peptide complexes
Venetz N; Müller S; Schulte T; Fischer S; Paladino M; Pina N; Kadri N; Bruckmaier S; Cornelius A; Hospodarsch T; Sandalova T; Levitsky V; Achour A; Walser M
Article: ACS NANO. 2021;15(4):7500-7512
Clustering of Major Histocompatibility Complex-Class I Molecules in Healthy and Cancer Colon Cells Revealed from Their Nanomechanical Properties
Moretti M; La Rocca R; Donnorso MP; Torre B; Canale C; Malerba M; Das G; Sottile R; Garofalo C; Achour A; Karre K; Carbone E; Di Fabrizio E
Article: SCIENTIFIC REPORTS. 2020;10(1):22455
The serine protease HtrA plays a key role in heat-induced dispersal of pneumococcal biofilms
Chao Y; Bergenfelz C; Sun R; Han X; Achour A; Hakansson AP
Article: BIOMOLECULAR NMR ASSIGNMENTS. 2020;14(2):195-200
Assigned NMR backbone resonances of the ligand-binding region domain of the pneumococcal serine-rich repeat protein (PsrP-BR) reveal a rigid monomer in solution
Schulte T; Sala BM; Nilvebrant J; Nygren P-A; Achour A; Shernyukov A; Agback T; Agback P
Article: NATURE COMMUNICATIONS. 2020;11(1):4420
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
Hanke L; Perez LV; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GBK; Haellberg BM; Murrell B; McInerney GM
Article: PLOS PATHOGENS. 2020;16(9):e1008855
SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity
De Meo S; Dell'Oste V; Molfetta R; Tassinari V; Lotti LV; Vespa S; Pignoloni B; Covino DA; Fantuzzi L; Bona R; Zingoni A; Nardone I; Biolatti M; Coscia A; Paolini R; Benkirane M; Edfors F; Sandalova T; Achour A; Hiscott J; Landolfo S; Santoni A; Cerboni C
Article: BMC IMMUNOLOGY. 2020;21(1):27
Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
Gerstner C; Turcinov S; Hensvold AH; Chemin K; Uchtenhagen H; Ramwadhdoebe TH; Dubnovitsky A; Kozhukh G; Ronnblom L; Kwok WW; Achour A; Catrina A; van Baarsen LGM; Malmstrom V
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(9):E3235-3235
Glycosylation Tunes Neuroserpin Physiological and Pathological Properties
Visentin C; Broggini L; Sala BM; Russo R; Barbiroli A; Santambrogio C; Nonnis S; Dubnovitsky A; Bolognesi M; Miranda E; Achour A; Ricagno S
Article: PLOS PATHOGENS. 2020;16(5):e1008244
Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination
Duru AD; Sun R; Allerbring EB; Chadderton J; Kadri N; Han X; Peqini K; Uchtenhagen H; Madhurantakam C; Pellegrino S; Sandalova T; Nygren P-A; Turner SJ; Achour A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2020;50(4):494-504
IL-15 and CD155 expression regulate LAT expression in murine DNAM1⁺ NK cells, enhancing their effectors functions
Luu TT; Wagner AK; Schmied L; Meinke S; Freund JE; Kambayashi T; Ravens I; Achour A; Bernhardt G; Chambers BJ; Hoglund P; Kadri N
Article: THE FEBS JOURNAL. 2020;287(3):546-560
Biochemical and biophysical comparison of human and mouse beta-2 microglobulin reveals the molecular determinants of low amyloid propensity
Achour A; Broggini L; Han X; Sun R; Santambrogio C; Buratto J; Visentin C; Barbiroli A; De Luca CMG; Sormanni P; Moda F; De Simone A; Sandalova T; Grandori R; Camilloni C; Ricagno S
Article: ARTHRITIS & RHEUMATOLOGY. 2020;72(1):179-191
Proinflammatory Histidyl-Transfer RNA Synthetase-Specific CD4+T Cells in the Blood and Lungs of Patients With Idiopathic Inflammatory Myopathies
Galindo-Feria AS; Albrecht I; Fernandes-Cerqueira C; Notarnicola A; James EA; Herrath J; Dastmalchi M; Sandalova T; Ronnblom L; Jakobsson P-J; Fathi M; Achour A; Grunewald J; Malmstrom V; Lundberg IE
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:437
Interaction With 14-3-3 Correlates With Inactivation of the RIG-I Signalosome by Herpesvirus Ubiquitin Deconjugases
Gupta S; Yla-Anttila P; Sandalova T; Achour A; Masucci MG
Article: PLOS PATHOGENS. 2019;15(11):e1008146
14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases
Gupta S; Yla-Anttila P; Sandalova T; Sun R; Achour A; Masucci MG
Article: JCI INSIGHT. 2019;4(9):126492
B cell profiling in malaria reveals expansion and remodeling of CD11c⁺ B cell subsets
Sundling C; Ronnberg C; Yman V; Asghar M; Jahnmatz P; Lakshmikanth T; Chen Y; Mikes J; Forsell MN; Sonden K; Achour A; Brodin P; Persson KEM; Farnert A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(11):5055-5060
Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin
Hafstrand I; Sayitoglu EC; Apavaloaei A; Josey BJ; Sun R; Han X; Pellegrino S; Ozkazanc D; Potens R; Janssen L; Nilvebrant J; Nygren P-A; Sandalova T; Springer S; Georgoudaki A-M; Duru AD; Achour A
Article: EBIOMEDICINE. 2019;40:517-527
B cell alterations during BAFF inhibition with belimumab in SLE
Ramskold D; Parodis I; Lakshmikanth T; Sippl N; Khademi M; Chen Y; Zickert A; Mikes J; Achour A; Amara K; Piehl F; Brodin P; Gunnarsson I; Malmstrom V
Article: AUTOIMMUNITY. 2019;52(1):1-11
Individual and stable autoantibody repertoires in healthy individuals
Neiman M; Hellstrom C; Just D; Mattsson C; Fagerberg L; Schuppe-Koistinen I; Gummesson A; Bergstrom G; Kallioniemi O; Achour A; Sallinen R; Uhlen M; Nilsson P
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2249
The Complement System Is Essential for the Phagocytosis of Mesenchymal Stromal Cells by Monocytes
Gavin C; Meinke S; Heldring N; Heck KA; Achour A; Iacobaeus E; Le Blanc K; Kadri N; Hoglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;89(1):e12732
Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis
Tang Q; Ramskold D; Krystufkova O; Mann HF; Wick C; Dastmalchi M; Lakshmikanth T; Chen Y; Mikes J; Alexanderson H; Achour A; Brodin P; Vencovsky J; Lundberg IE; Malmstrom V
Article: NATURE MICROBIOLOGY. 2019;4(1):62-70
Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival
Subramanian K; Neill DR; Malak HA; Spelmink L; Khandaker S; Marchiori GDL; Dearing E; Kirby A; Yang M; Achour A; Nilvebrant J; Nygren P-A; Plant L; Kadioglu A; Henriques-Normark B
Article: ANALYTICA CHIMICA ACTA. 2018;1025:118-123
Bioanalytical advantages of a novel recombinant apyrase enzyme in ATP-based bioluminescence methods
Pavankumar AR; Zelenin S; Lundin A; Schulte T; Rajarathinam K; Rebellato P; Ardabili S; Salas J; Achour A; Russom A
Article: JOURNAL OF AUTOIMMUNITY. 2018;92:47-56
Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint
Pieper J; Dubnovitsky A; Gerstner C; James EA; Rieck M; Kozhukh G; Tandre K; Pellegrino S; Gebe JA; Ronnblom L; Sandalova T; Kwok WW; Klareskog L; Buckner JH; Achour A; Malmstrom V
Article: IMMUNOHORIZONS. 2018;2(6):172-184
Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.
Lampen MH; Uchtenhagen H; Blom K; Varnaitė R; Pakalniene J; Dailidyte L; Wälchli S; Lindquist L; Mickiene A; Michaëlsson J; Schumacher TN; Ljunggren H-G; Sandberg JK; Achour A; Gredmark-Russ S
Article: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2018;102(9):4193-4201
Detecting ligand interactions in real time on living bacterial cells
Encarnacao JC; Schulte T; Achour A; Bjorkelund H; Andersson K
Article: JOURNAL OF IMMUNOLOGY. 2018;200(8):2860-2868
The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability
Hafstrand I; Doorduijn EM; Sun R; Talyzina A; Sluijter M; Pellegrino S; Sandalova T; Duru AD; van Ha T; Achour A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(4):1523-1537
LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions
Yu K; Davidson CL; Wojtowicz A; Lisboa L; Wang T; Airo AM; Villard J; Buratto J; Sandalova T; Achour A; Humar A; Boggian K; Cusini A; van Delden C; Egli A; Manuel O; Mueller N; Bochud P-Y; Burshtyn DN
Article: OPEN BIOLOGY. 2018;8(4):170248
Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in Streptococcus pneumoniae
Han X; Sun R; Sandalova T; Achour A
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:926
Mica-129 Dimorphism and soluble Mica are associated With the Progression of Multiple Myeloma
Zingoni A; Vulpis E; Cecere F; Amendola MG; Fuerst D; Saribekyan T; Achour A; Sandalova T; Nardone I; Peri A; Soriani A; Fionda C; Mariggo E; Petrucci MT; Ricciardi MR; Mytilineos J; Cippitelli M; Cerboni C; Santoni A
Article: JOURNAL OF NEUROIMMUNOLOGY. 2017;303:1-12
Nitration of MOG diminishes its encephalitogenicity depending on MHC haplotype
Warnecke A; Musunuri S; N'diaye M; Sandalova T; Achour A; Bergquist J; Harris RA
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1130
Mass Cytometry Identifies Distinct Lung CD4⁺ T Cell Patterns in Lofgren's Syndrome and Non-Lofgren's Syndrome Sarcoidosis
Kaiser Y; Lakshmikanth T; Chen Y; Mikes J; Eklund A; Brodin P; Achour A; Grunewald J
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:717
Combining Flow and Mass Cytometry in the Search for Biomarkers in Chronic Graft-versus-Host Disease
Stikvoort A; Chen Y; Radestad E; Torlen J; Lakshmikanth T; Bjorklund A; Mikes J; Achour A; Gertow J; Sundberg B; Remberger M; Sundin M; Mattsson J; Brodin P; Uhlin M
Article: PLOS ONE. 2017;12(12):e0189584
Crystal structures of H-2D^b in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity
Hafstrand I; Badia-Martinez D; Josey BJ; Norstrom M; Buratto J; Pellegrino S; Duru AD; Sandalova T; Achour A
Article: CELLULAR MICROBIOLOGY. 2016;18(11):1537-1550
Migratory activation of parasitized dendritic cells by the protozoan Toxoplasma gondii 14-3-3 protein
Weidner JM; Kanatani S; Uchtenhagen H; Varas-Godoy M; Schulte T; Engelberg K; Gubbels M-J; Sun HS; Harrison RE; Achour A; Barragan A
Article: SCIENTIFIC REPORTS. 2016;6:32371
The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation
Schulte T; Mikaelsson C; Beaussart A; Kikhney A; Deshmukh M; Wolniak S; Pathak A; Ebel C; Lofling J; Fogolari F; Henriques-Normark B; Dufrene YF; Svergun D; Nygren P-A; Achour A
Article: MOLECULAR MICROBIOLOGY. 2016;101(6):954-967
The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity
Sandalova T; Lee M; Henriques-Normark B; Hesek D; Mobashery S; Mellroth P; Achour A
Article: OPEN BIOLOGY. 2016;6(7):160078
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication
Schulte T; Liu L; Panas MD; Thaa B; Dickson N; Gotte B; Achour A; McInerney GM
Article: JOURNAL OF IMMUNOLOGY. 2016;196(5):2327-2334
The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer
Hafstrand I; Doorduijn EM; Duru AD; Buratto J; Oliveira CC; Sandalova T; van Hall T; Achour A
Article: EUROPEAN RESPIRATORY JOURNAL. 2016;47(3):898-909
T-cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis
Grunewald J; Kaiser Y; Ostadkarampour M; Rivera NV; Vezzi F; Lotstedt B; Olsen R-A; Sylwan L; Lundin S; Kaller M; Sandalova T; Ahlgren KM; Wahlstrom J; Achour A; Ronninger M; Eklund A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2016;126(2):784-794
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors
Doorduijn EM; Sluijter M; Querido BJ; Oliveira CC; Achour A; Ossendorp F; van der Burg SH; van Hall T
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:494
Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis
Gerstner C; Dubnovitsky A; Sandin C; Kozhukh G; Uchtenhagen H; James EA; Ronnelid J; Ytterberg AJ; Pieper J; Reed E; Tandre C; Rieck M; Zubarev RA; Ronnblom L; Sandalova T; Buckner JH; Achour A; Malmstrom V
Article: CELL REPORTS. 2015;10(9):1626-1638
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation
Burguillos MA; Svensson M; Schulte T; Boza-Serrano A; Garcia-Quintanilla A; Kavanagh E; Santiago M; Viceconte N; Jose Oliva-Martin M; Osman AM; Salomonsson E; Amar L; Persson A; Blomgren K; Achour A; Englund E; Leffler H; Venero JL; Joseph B; Deierborg T
Article: PLOS PATHOGENS. 2015;11(2):e1004659
Viral and Cellular Proteins Containing FGDF Motifs Bind G3BP to Block Stress Granule Formation
Panas MD; Schulte T; Thaa B; Sandalova T; Kedersha N; Achour A; McInerney GM
Article: PLOS ONE. 2015;10(3):e0118898
Binding of Subdomains 1/2 of PfEMP1-DBL1α to Heparan Sulfate or Heparin Mediates Plasmodium falciparum Rosetting
Angeletti D; Sandalova T; Wahlgren M; Achour A
Article: BMC BIOINFORMATICS. 2014;15(1):370
PyTMs: a useful PyMOL plugin for modeling common post-translational modifications
Warnecke A; Sandalova T; Achour A; Harris RA
Article: JOURNAL OF CELL SCIENCE. 2014;127(13):2885-2897
Peptide-independent stabilization of MHC class I molecules breaches cellular quality control
Hein Z; Uchtenhagen H; Abualrous ET; Saini SK; Janssen L; Van Hateren A; Wiek C; Hanenberg H; Momburg F; Achour A; Elliott T; Springer S; Boulanger D
Article: JOURNAL OF IMMUNOLOGY. 2014;192(12):5802-5812
Boosting of HIV-1 Neutralizing Antibody Responses by a Distally Related Retroviral Envelope Protein
Uchtenhagen H; Schiffner T; Bowles E; Heyndrickx L; LaBranche C; Applequist SE; Jansson M; De Silva T; Back JW; Achour A; Scarlatti G; Fomsgaard A; Montefiori D; Stewart-Jones G; Spetz A-L
Article: IMMUNOBIOLOGY. 2014;219(3):189-197
Melanocortin 1 Receptor-derived peptides are efficiently recognized by cytotoxic T lymphocytes from melanoma patients
Gonzalez FE; Ramirez M; Allerbring EB; Fasching N; Lundqvist A; Poschke I; Achour A; Saazar-Onfray F
Article: MBIO. 2014;5(1):e01120-e01113
Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae
Mellroth P; Sandalova T; Kikhney A; Vilaplana F; Hesek D; Lee M; Mobashery S; Normark S; Svergun D; Henriques-Normark B; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(6):3318-3327
Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β₂-Microglobulin
Halabelian L; Ricagno S; Giorgetti S; Santambrogio C; Barbiroli A; Pellegrino S; Achour A; Grandori R; Marchese L; Raimondi S; Mangione PP; Esposito G; Al-Shawi R; Simons JP; Speck I; Stoppini M; Bolognesi M; Bellotti V
Article: OPEN BIOLOGY. 2014;4(1):130090
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold
Schulte T; Lofling J; Mikaelsson C; Kikhney A; Hentrich K; Diamante A; Ebel C; Normark S; Svergun D; Henriques-Normark B; Achour A
Article: PLOS ONE. 2014;9(10):e111041
Designing a Multimer Allergen for Diagnosis and Immunotherapy of Dog Allergic Patients
Nilsson OB; Neimert-Andersson T; Bronge M; Grundstrom J; Sarma R; Uchtenhagen H; Kikhney A; Sandalova T; Holmgren E; Svergun D; Achour A; van Hage M; Gronlund H
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2013;43(11):3051-3060
Proline substitution independently enhances H-2D^b complex stabilization and TCR recognition of melanoma-associated peptides
Uchtenhagen H; Abualrous ET; Stahl E; Allerbring EB; Sluijter M; Zacharias M; Sandalova T; van Hall T; Springer S; Nygren P-A; Achour A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2013;43(4):1042-1052
Cis association of leukocyte Ig-like receptor 1 with MHC class I modulates accessibility to antibodies and HCMV UL18
Li NL; Fu L; Uchtenhagen H; Achour A; Burshtyn DN
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(11):2990-3000
Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics
Allerbring EB; Duru AD; Uchtenhagen H; Madhurantakam C; Tomek MB; Grimm S; Mazumdar PA; Friemann R; Uhlin M; Sandalova T; Nygren P-A; Achour A
Article: PLOS ONE. 2012;7(3):e32805
Inflammation-Associated Nitrotyrosination Affects TCR Recognition through Reduced Stability and Alteration of the Molecular Surface of the MHC Complex
Madhurantakam C; Duru AD; Sandalova T; Webb JR; Achour A
Article: PLOS ONE. 2012;7(12):e50758
Plasmodium falciparum Rosetting Epitopes Converge in the SD3-Loop of PfEMP1-DBL1α
Angeletti D; Albrecht L; Blomqvist K; del Pilar Quintana M; Akhter T; Bachle SM; Sawyer A; Sandalova T; Achour A; Wahlgren M; Moll K
Article: PLOS ONE. 2011;6(4):e18767
Crystal Structure of the HIV-2 Neutralizing Fab Fragment 7C8 with High Specificity to the V3 Region of gp125
Uchtenhagen H; Friemann R; Raszewski G; Spetz A-L; Nilsson L; Achour A
Article: PLOS ONE. 2011;6(6):e20135
Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge
Borggren M; Repits J; Sterjovski J; Uchtenhagen H; Churchill MJ; Karlsson A; Albert J; Achour A; Gorry PR; Fenyo EM; Jansson M
Article: PLOS ONE. 2011;6(12):e29523
Multiple Polymorphisms Affect Expression and Function of the Neuropeptide S Receptor (NPSR1)
Anedda F; Zucchelli M; Schepis D; Hellquist A; Corrado L; D'Alfonso S; Achour A; McInerney G; Bertorello A; Lordal M; Befrits R; Bjork J; Bresso F; Torkvist L; Halfvarson J; Kere J; D'Amato M
Article: PLOS ONE. 2010;5(10):e13174
Natural Killer Cell Tolerance Persists Despite Significant Reduction of Self MHC Class I on Normal Target Cells in Mice
Brodin P; Lakshmikanth T; Mehr R; Johansson MH; Duru AD; Achour A; Salmon-Divon M; Karre K; Hoglund P; Johansson S
Article: JOURNAL OF IMMUNOLOGY. 2010;185(6):3574-3582
Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-Encoded Genes Determine Susceptibility in Congenital Heart Block
Strandberg LS; Ambrosi A; Jagodic M; Dzikaite V; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Aden U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Article: PLOS PATHOGENS. 2010;6(9):e1001084
Generation of Neutralizing Antibodies and Divergence of SIVmac239 in Cynomolgus Macaques Following Short-Term Early Antiretroviral Therapy
Sahin GO; Bowles EJ; Parker J; Uchtenhagen H; Sheik-Khalil E; Taylor S; Pybus OG; Makitalo B; Walther-Jallow L; Spangberg M; Thorstensson R; Achour A; Fenyo EM; Stewart-Jones GBE; Spetz A-L
Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;401(1):68-83
Crystal Structure of the Dog Lipocalin Allergen Can f 2: Implications for Cross-reactivity to the Cat Allergen Fel d 4
Madhurantakam C; Nilsson OB; Uchtenhagen H; Konradsen J; Saarne T; Hogbom E; Sandalova T; Gronlund H; Achour A
Article: JOURNAL OF MOLECULAR BIOLOGY. 2009;393(3):704-716
Two Crystal Structures of Pneumococcal Pilus Sortase C Provide Novel Insights into Catalysis and Substrate Specificity
Neiers F; Madhurantakam C; Falker S; Manzano C; Dessen A; Normark S; Henriques-Normark B; Achour A
Article: CANCER RESEARCH. 2009;69(19):7784-7792
Design of Agonistic Altered Peptides for the Robust Induction of CTL Directed towards H-2D^b in Complex with the Melanoma-Associated Epitope gp100
van Stipdonk MJB; Badia-Martinez D; Sluijter M; Offringa R; van Hall T; Achour A
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 7):705-708
Production, purification, crystallization and preliminary X-ray diffraction analysis of the HIV-2-neutralizing V3 loop-specific Fab fragment 7C8
Uchtenhagen H; Sourial S; Friemann R; Ehnlund M; Spetz A-L; Harris RA; Madhurantakam C; Achour A
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 5):467-471
Production, crystallization and preliminary X-ray diffraction analysis of the allergen Can f 2 from Canis familiaris
Madhurantakam C; Nilsson OB; Jonsson K; Gronlund H; Achour A
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 1):55-58
Cloning, expression, purification, crystallization and preliminary X-ray analysis of the pilus-associated sortase C from Streptococcus pneumoniae
Neiers F; Madhurantakam C; Falker S; Normark S; Henriques-Normark B; Achour A
Article: MOLECULAR IMMUNOLOGY. 2008;46(2):294-303
Mutational analysis of amino acid residues involved in IgE-binding to the Malassezia sympodialis allergen Mala s 11
Vilhelmsson M; Glaser AG; Martinez DB; Schmidt M; Johansson C; Rhyner C; Berndt KD; Scheynius A; Crameri R; Achour A; Zargari A
Article: VIROLOGY. 2008;379(1):125-134
Primary HIV-1 R5 isolates from end-stage disease display enhanced viral fitness in parallel with increased gp120 net charge
Repits J; Sterjovski J; Badia-Martinez D; Mild M; Gray L; Churchill MJ; Purcell DFJ; Karlsson A; Albert J; Fenyoe EM; Achour A; Gorry PR; Jansson M
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;83(1):56-63
Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells
Wagner CS; Walther-Jallow L; Buentke E; Ljunggren H-G; Achour A; Chambers BJ
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;373(3):695-705
Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1
Wagner CS; Roelle A; Cosman D; Ljunggren H-G; Berndt KD; Achour A
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;370(4):714-727
Structural characterization of the tetrameric form of the major cat allergen Fel d 1
Kaiser L; Velickovic TC; Badia-Martinez D; Adedoyin J; Thunberg S; Hallen D; Berndt K; Gronlund H; Gafvelin G; van Hage M; Achour A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2007;37(7):1986-1995
Malondialdehyde modification of myelin oligodendrocyte glycoprotein leads to increased immunogenicity and encephalitogenicity
Wallberg M; Bergquist J; Achour A; Breij E; Harris RA
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;369(4):1079-1086
Crystal structure of the major Malassezia sympodialis allergen mala s 1 reveals a β-propeller fold:: A novel fold among allergens
Vilhelmsson M; Zargari A; Crameri R; Rasool O; Achour A; Scheynius A; Hallberg BM
Article: CURRENT HIV RESEARCH. 2006;4(2):229-237
Deletion of the V1/V2 region does not increase the accessibility of the V3 region of recombinant gp125
Sourial S; Nilsson C; Wärnmark A; Achour A; Harris RA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(13):8950-8957
Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules - Prominent role of a single arginine residue in human leukocyte antigen-A2
Thilo C; Berglund P; Applequist SE; Yewdell JW; Ljunggren HG; Achour A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2006;36(3):732-741
Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR-1/ILT2/CD85j
Cerboni C; Achour A; Wärnmark A; Mousavi-Jazi M; Sandalova T; Hsu ML; Cosman D; Kärre K; Carbone E
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396
Structural basis of the differential stability and receptor specificity of H-2D^b in complex with murine versus human β₂-microglobulin
Achour A; Michaëlsson T; Harris RA; Ljunggren HG; Kärre M; Schneider G; Sandalova T
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2006;62(Pt 2):97-99
Crystallization and preliminary crystallographic study of the yeast Malassezia sympodialis allergen Mala s 1
Vilhelmsson M; Hallberg BM; Rasool O; Zargari A; Scheynius A; Achour A
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093
Expression, refolding and crystallization of murine MHC class IH-2D^b in complex with human β₂-microglobulin
Sandalova T; Michaëlsson J; Harris RA; Ljunggren HG; Kärre K; Schneider G; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075
A structural basis for CD8⁺ T cell-dependent recognition of non-homologous peptide ligands -: Implications for molecular mimicry in autoreactivity
Sandalova T; Michaëlsson J; Harris RA; Odeberg J; Schneider G; Kärres K; Achour A
Article: MOLECULAR BIOTECHNOLOGY. 2005;30(2):155-162
Cloning, expression, and purification of HIV-2 gp125
Sourial S; Wärnmark A; Nilsson C; Björling E; Achour A; Harris RA
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 2):232-234
Crystallization and preliminary crystallographic data of a Fel d 1 (1+2) construct corresponding to the major allergen from cat
Kaiser L; Grönlund H; van Hage-Hamsten MV; Achour A
Article: JOURNAL OF IMMUNOLOGY. 2004;172(9):5504-5511
Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition
Velloso LM; Michaëlsson J; Ljunggren HG; Schneider G; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(39):37730-37735
The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family
Kaiser L; Grönlund H; Sandalova T; Ljunggren HG; van Hage-Hamsten M; Achour A; Schneider G
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2003;132(1):25-26
Three-dimensional structure of Fel d 1, the major allergen in cat
Kaiser L; Grönlund H; Sandalova T; Ljunggren HG; Achour A; Schneider G; van Hage-Hamsten M
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2003;59(Pt 6):1103-1105
Production, crystallization and preliminary crystallographic study of the major cat allergen Fel d I
Kaiser L; Grönlund H; Sandalova T; Ljunggren HG; Schneider G; van Hage-Hamsten M; Achour A
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2002;196(11):1403-1414
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition
Michaëlsson J; de Matos CT; Achour A; Lanier LL; Kärre K; Söderström K
Article: IMMUNITY. 2002;17(6):757-768
A structural basis for LCMV immune evasion:: Subversion of H-2D^b and H-2K^b presentation of gp33 revealed by comparative crystal structure analyses
Achour A; Michaëlsson J; Harris RA; Odeberg J; Grufman P; Sandberg JK; Levitsky V; Kärre K; Sandalova T; Schneider G
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):129-139
The role of an exposed loop in the α₂ domain in the mouse MHC class IH-2D_d molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A
Waldenström M; Achour A; Michaelsson J; Rölle A; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):793-800
NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding
Sundbäck J; Achour A; Michaëlsson J; Lindström H; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(12):3602-3611
The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65
Charo J; Geluk A; Sundbäck M; Mirzai B; Diehl AD; Malmberg KJ; Achour A; Huriguchi S; van Meijgaarden KE; Drijfhout JW; Beekman N; van Veelen P; Ossendorp F; Ottenhoff THM; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 2001;166(12):7327-7334
MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the β₂-microglobulin subunit
Michaëlsson J; Achour A; Rölle A; Kärre K
Article: VIROLOGY. 2000;273(1):112-119
Human immunodeficiency virus type 1 Nef epitopes recognized in HLA-A2 transgenic mice in response to DNA and peptide immunization
Sandberg JK; Leandersson AC; Devito C; Kohleisen B; Erfle V; Achour A; Levi M; Schwartz S; Kärre K; Wahren B; Hinkula J
Article: JOURNAL OF IMMUNOLOGY. 2000;165(1):25-33
T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity
Sandberg JK; Franksson L; Sundbäck J; Michaelsson J; Petersson M; Achour A; Wallin RPA; Sherman NE; Bergman T; Jörnvall H; Hunt DF; Kiessling R; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307
Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers
Michaëlsson J; Achour A; Salcedo M; Kåse-Sjöström A; Sundbäck J; Harris RA; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1999;29(9):2748-2758
Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C
Franksson L; Sundbäck J; Achour A; Bernlind J; Glas R; Kärre K
Article: VIRUS RESEARCH. 1999;59(1):49-60
Fine characterization of a V3-region neutralizing epitope in human immunodeficiency virus type 2
Mörner A; Achour A; Norin M; Thorstensson R; Björling E
Article: VIRAL IMMUNOLOGY. 1999;12(1):79-88
Characterization of neutralizing sites in the second variable and fourth variable region in gp125 and a conserved region in gp36 of human immunodeficiency virus type 2
Skott P; Achour A; Norin M; Thorstensson R; Björling E
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1999;55(Pt 1):260-262
Murine class I major histocompatibility complex H-2D^d:: expression, refolding and crystallization
Achour A; Harris RA; Persson K; Sundbäck J; Sentman CL; Schneider G; Lindqvist Y; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(9):2872-2881
Impaired MHC class I (H-2D^d)-mediated protection against Ly-49A⁺ NK cells after amino acid substitutions in the antigen binding cleft
Waldenström M; Sundbäck J; Olsson-Alheim MY; Achour A; Kärre K
Article: IMMUNITY. 1998;9(2):199-208
The crystal structure of H-2D^d MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 Å resolution:: Implications for T cell and NK cell recognition
Achour A; Persson K; Harris RA; Sundbäck J; Sentman CL; Lindqvist Y; Schneider G; Kärre K
Article: INTERNATIONAL IMMUNOLOGY. 1998;10(2):131-140
A three-dimensional model of the Fas/APO-1 molecule: cross-reactivity of anti-Fas antibodies explained by structural mimicry of antigenic sites
Fadeel B; Lindberg J; Achour A; Chiodi F
Article: MOLECULAR IMMUNOLOGY. 1995;32(11):789-794
ALTERED MHC CLASS-I PRESENTED PEPTIDE REPERTOIRE IS NOT SUFFICIENT TO INDUCE NK CELL-MEDIATED F-1-HYBRID RESISTANCE
SALCEDO M; HOGLUND P; ACHOUR A; THORPE CJ; LJUNGGREN HG
Journal article: PROTEIN SCIENCE. 1994;3(9):1493-1503
Computer modeling of substrate binding to lipases from Rhizomucor miehei, Humicola lanuginosa, and Candida rugosa.
Norin M; Haeffner F; Achour A; Norin T; Hult K
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Agback T; Lesovoy D; Han X; Lomzov A; Sun R; Sandalova T; Orekhov V; Achour A; Agback P
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Ragaller F; Andronico L; Achour A; Sezgin E
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Qiu T; Jahangiri A; Han X; Lesovoy D; Agback T; Agback P; Achour A; Qu X; Orekhov V
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NMR spectrum reconstruction as a pattern recognition problem
Jahangiri A; Han X; Lesovoy D; Agback T; Agback P; Achour A; Orekhov V
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Assignment of IVL-Methyl side chain of the ligand-free monomeric human MALT1 paracaspase-IgL 3 domain in solution
Han X; Levkovets M; Lesovoy D; Sun R; Wallerstein J; Sandalova T; Agback T; Achour A; Agback P; Orekhov VY
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Sandalova T; Sala BM; Achour A
Preprint: BIORXIV. 2021
PD-1 expression on NK cells can be related to cytokine stimulation and tissue residency
Wagner A; Kadri N; Tibbitt C; van de Ven K; Bagawath-Singh S; Oliinyk D; LeGresly E; Campbell N; Trittel S; Riese P; Sandalova T; Achour A; Kärre K; Chambers B
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Targeted enzyme assisted chemotherapy (TEAC) – a novel microRNA-guided and selenium-based regimen to specifically eradicate hepatocellular carcinoma
Selvam AK; Jawad R; Gramignoli R; Achour A; Salter H; Björnstedt M
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Caprin-1 binding to the critical stress granule protein G3BP1 is regulated by pH
Schulte T; Panas MD; Williams L; Kedersha N; Fleck JS; Tan TJC; Olsson A; Morro AM; Hanke L; Nilvebrant J; Giang KA; Nygren P-Å; Anderson P; Achour A; McInerney GM
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FOXO1 and FOXO3 cooperatively regulate innate lymphoid cell development
Luu T; Søndergaard JN; Peña-Pérez L; Kharazi S; Krstic A; Meinke S; Schmied L; Frengen N; Heshmati Y; Kierczak M; Bouderlique T; Wagner AK; Gustafsson C; Chambers B; Achour A; Kutter C; Höglund P; Månsson R; Kadri N
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Application of the DARPin® technology for specific targeting of tumor-associated MHC class I:peptide complexes.
Venetz N; Mueller S; Schulte T; Fischer S; Paladino M; Pina N; Kadri N; Bruckmaier S; Cornelius A; Hospodarsch T; Sandalova T; Levitsky V; Achour A; Walser M
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Application of the DARPin® technology for specific targeting of tumor-associated MHC class I:peptide complexes
Walcer M; Venetz N; Schulte T; Fischer S; Bassler N; Paladino M; Pina N; Villemagne D; Bruckmaier S; Cornelius A; Hospodarsch T; Duffet L; Sandalova T; Achour A; Levitsky V
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An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
Hanke L; Perez LV; Sheward D; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GK; Hällberg M; Murrell B; McInerney G
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Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
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Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
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Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination
Duru AD; Sun R; Allerbring E; Chadderton J; Kadri N; Han X; Uchtenhagen H; Madhurantakam C; Pellegrino S; Sandalova T; Nygren P-Å; Turner S; Achour A
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Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis
Gerstner C; Turcinov S; Hensvold AH; Chemin K; Uchtenhagen H; Ramwadhdoebe TH; Dubnovitsky A; Kozhukh G; Rönnblom L; Kwok WW; Achour A; Catrina AI; Baarsen LGMV; Malmström V
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Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses
Subramanian K; Neill DR; Malak HA; Spelmink L; Khandaker S; Marchiori GDL; Dearing E; Kirby A; Yang M; Achour A; Nilvebrant J; Nygren P-A; Plant L; Kadioglu A; Henriques-Normark B
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02.09 Identification of a novel pro-inflammatory T cell epitope from his-trna-synthetase associated with interstitial lung disease in anti-jo-1 positive patients
Galindo-Feria AS; Albrecht I; Notarnicola A; Dastmalchi M; Dubnovitsky A; Sandalova T; Kozhukh G; Rönnblom L; Achour A; Malmström V; Lundberg IE
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104 A mass cytometry (CYTOF) approach to study B cell alterations during baff blockade treatment with belimumab in systemic lupus erythematosus
Parodis I; Ramsköld D; Tadepally L; Chen Y; Zickert A; Mikes J; Amara K; Achour A; Brodin P; Gunnarsson I; Malmström V
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Identification of a novel pro-inflammatory T cell epitope from his-tRNA-synthetase associated with interstitial lung disease in anti-Jo-1 positive patients
Galindo-Feria AS; Albrecht I; Notarnicola A; Dastmalchi M; Dubnovitsky A; Sandalova T; Kozhukh G; Ronnblom L; Achour A; Malmstrom V; Lundberg I
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Effect of abatacept treatment on T cells in peripheral blood and muscle tissue in polymyositis and dermatomyositis patients
Tang Q; Ramskold D; Krystufkova O; Mann HF; Wick C; Dastmalchi M; Chen Y; Lakshmikanth T; Alexanderson H; Achour A; Mikes J; Brodin P; Vencovsky J; Lundberg IE; Malmstrom V
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Vaccination with proline-substituted neoepitope Trh4 generates enhanced CTL responses against tumors
Hafstrand I; Doorduijn EM; Duru AD; Sun R; Talyzina A; Sluijter M; Buratto J; Pellegrino S; Oliveira CC; Sandalova T; van Hall T; Achour A
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Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis (vol 7, 494, 2016)
Gerstner C; Dubnovitsky A; Sandin C; Kozhukh G; Uchtenhagen H; James EA; Ronnelid J; Ytterberg AJ; Pieper J; Reed E; Tandre K; Rieck M; Zubarev RA; Ronnblom L; Sandalova T; Buckner JH; Achour A; Malmstrom V
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Lung-Specific Clonality And Plasticity Of T Cell Receptor-Restricted Cd4+T Cells In Sarcoidosis - Implications For Pulmonary Antigen Recognition
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TCR-HLA interactions implicate vimentin as a candidate autoantigen in pulmonary sarcoidosis
Kaiser Y; Dubnovitsky A; Sandalova T; Eklund A; Achour A; Grunewald J
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68
Observations of Early and Late B Cell Alterations during Belimumab Treatment in Patients with Systemic Lupus Erythematosus Using Mass Cytometry (CyTOF)
Parodis I; Ramskold D; Brodin P; Zickert A; Tadepally L; Chen Y; Mikes J; Achour A; Gurmarsson I; Malmstrom V
Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2015;71:S277
The keratin-10 binding region of the pneumococcal scrinc rich repeat protein (PsrP) forms a domain-swapped dimcr and intermolecular 13-sheets implications for biofilm formation of Streptococcus pneumonicte
Schulte T; Lofling J; Mikaelsson C; Kikhney A; Hentrich K; Diamante A; Ebel C; Normark S; Svergun D; Heniques-Normark B; Achour A
Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2015;71:S225
Structural basis of the peptidoglycan binding to LytA, the major pneumococcal autolysin
Sandalova T; Henriques-Normark B; Hesek D; Lee M; Mobashery S; Kikhney A; Svergun D; Mellroth P; Achour A
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67
Generation and Immunophenotyping of Citrullin-Specific T Cell Lines from Peripheral Blood and Synovial Fluid of ACPA plus RA Patients
Mia MS; Gerstner C; Ramskold D; Herrath J; Dubnovitsky A; Marline M; van Vollenhoven A; Deng Q; Achour A; Malmstrom V
Conference publication: MOLECULAR IMMUNOLOGY. 2015;68(2):151
Structural and thermodynamic basis underlying in vivo reestablishment of T-cell recognition of a viral escape mutant
Allerbring EB; Duru AD; Chadderton J; Markov N; Uchtenhagen H; Popov A; Madhurantakam C; Sandalova T; Turner SJ; Nygren P-A; Achour A
Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2014;275(1-2):73-74
PyTMs: A useful modeling tool for common post-translational modifications
Warnecke A; Sandalova T; Achour A; Harris RA
Corrigendum: OPEN BIOLOGY. 2014;4(10):140172
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold (vol 4, 130090, 2014)
Schulte T; Lofling J; Mikaelsson C; Kikhney A; Hentrich K; Diamante A; Ebel C; Normark S; Svergun D; Henriques-Normark B; Achour A
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:58
Differences in the autoreactive T-cell pool when restricted by the highly related rheumatoid arthritis-associated HLA-DRB1 alleles*04:01,*04:04, and*01:01
Sandin C; Gerstner C; Uchtenhagen H; James E; Pieper J; Rieck M; Achour A; Buckner JH; Sandalova T; Malmstrom V
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):440
Differences in the Autoreactive T Cell Pool When Restricted by the Highly Related Rheumatoid Arthritis-Associated HLA-DRB1 Alleles*04:01,*04:04 and*01:01
Sandin C; Gerstner C; Uchtenhagen H; James E; Pieper J; Rieck M; Achour A; Buckner J; Sandalova T; Malmstrom V
Meeting abstract: CANCER RESEARCH. 2013;73:b70
Generation of MAGE-A4 230-239 peptide-specific cytotoxic T lymphocytes using an alloreactive approach.
Lovgren T; Mao Y; Boschen M-L; Allerbring EB; Achour A; Poschke I; Kiessling R
Meeting abstract: CANCER RESEARCH. 2013;73:b41
Analysis of immune responses and tumor protection in C57/Bl6 mice immunized with altered CD8 survivin peptide ligands.
de Coana YP; Duru AD; Lladser A; Achour A; Kiessling R
Meeting abstract: MOLECULAR IMMUNOLOGY. 2012;51(1):33-34
Enhanced immunogenicity of MHC class I-restricted tumor-associated altered peptide ligands
Uchtenhagen H; Stahl E; Duru AD; Tolba E; Celie P; Springer S; van Hall T; Schumacher TN; Achour A
Conference publication: IMMUNOLOGY. 2012;137:715-716
Low affinity HLA-A2 restricted melanocortin 1 receptor-derived peptides are recognized by melanoma-specific CTLs and TILs from melanoma patients
Gonzalez FE; Ramirez M; Allerbring EB; Duru AD; Poschke I; Kiessling R; Achour A; Salazar-Onfray F
Conference publication: IMMUNOLOGY. 2011;135:70
The unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics and an alternative structural hotspot
Allerbring EB; Duru AD; Uchtenhagen H; Madhurantakam C; Tomek MB; Grimm S; Mazumdar PA; Friemann R; Sandalova T; Uhlin M; Nygren P-A; Achour A
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2010;26(10):A55
Increased sensitivity to neutralizing antibodies of end-stage disease R5 HIV-1 is concomitant with reduced gp120 glycosylation and increased plus charge
Fenyo E; Borggren M; Repits J; Sterjovski J; Uchtenhagen H; Karlsson A; Albert J; Achour A; Gorry PR; Jansson M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):269
MHC Genes Determine Fetal Susceptibility in a Rat Model of Congenital Heart Block
Dzikaite V; Strandberg LS; Ambrosi A; Jagodic M; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Aden U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):256
Consequence of exogenous HIV-1 nef protein on T cell and macrophage function
Mohanram V; Pathak SK; Behbahani H; Achour A; Basu J; Spetz A-L
Review: JOURNAL OF IMMUNOLOGY. 2008;180(1):19-24
Immune modulation by the human cytomegalovirus-encoded molecule UL18, a mystery yet to be solved
Wagner CS; Ljunggren H-G; Achour A
Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 2004;60:S174
Crystal structure of major cat allergen Fel d 1
Sandalova T; Kaiser L; Gronlund H; Ljunggren H-G; van Hage-Hamsten M; Achour A; Schneider G
Book chapter: ENCYCLOPEDIA OF LIFE SCIENCES. 2001;p.
Major Histocompatibility Complex: Interaction with Peptides
Achour A
Thesis / dissertation: 2000
Structural studies of MHC class 1 complexes : implications for NK- and T-cell recognition
Achour, Adnane
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Forskningsbidrag

Spot-on Biomolecular NMR with Deep Learning
Swedish Research Council
1 January 2024 - 31 December 2027
Strukturella och dynamiska grunder underliggande utökat CD8 T cellsaktivering i cancer och virala infektioner
Cancerfonden
1 January 2022 - 31 December 2024
Achour, Adnane – Structural and dynamic bases underlying enhanced CD8 T cell activation in cancer and viral infection
Swedish Cancer Society
1 January 2022
Structural and dynamic bases underlying enhanced T cell receptor recognition
Swedish Research Council
1 December 2021 - 30 November 2025
Development of a Universal Vaccine Against Influenza
Swedish Research Council
1 December 2021 - 30 November 2023
Structural and metabolic pathways underlying enhanced CD8 T cell activation in cancer and viral infection
Swedish Research Council
1 January 2019 - 31 December 2021
Combatting commensal pathogens belonging to the resident microbiota –focusing on targetable secreted proteins and secretion systems - SECAM
Swedish Research Council
1 December 2018 - 31 December 2023
Structural and metabolic pathways underlying elevated CD8-T cell activationin cancer and viral infection
Swedish Cancer Society
1 January 2018
Structural and functional studies for enhanced T cell receptor elimination of tumor cells
Swedish Cancer Society
1 January 2017
Enhanced CD8 T cell responses towards cancer targets using a combination of altered peptide ligands and modified mRNA vaccination
Swedish Research Council
1 January 2016 - 31 December 2016
Structural and functional studies for enhanced T cell receptor elimination of tumor cells
Swedish Cancer Society
1 January 2016
Structural and functional studies for enhanced T cell receptor elimination of tumor cells
Swedish Cancer Society
1 January 2015
Development of MHC class I-binding super-peptides for vaccines
Swedish Research Council
1 January 2014 - 31 December 2016
Development of a new generation of "superpeptides" for the production of cancer vaccines
Swedish Cancer Society
1 January 2014
Immunomodulation of host-microbe interactions-MOHICAN
Swedish Foundation for Strategic Research
1 August 2013 - 31 July 2018
Immuno-modulatory and clinical consequences of co-infections (IMCO)
Swedish Research Council
1 January 2013 - 31 December 2016
Structural basis for Streptococcus pneumonia virulence
Swedish Research Council
1 January 2013 - 31 December 2016
Development of innovative immunotherapeutic drugs
Swedish Foundation for Strategic Research
1 July 2011 - 30 June 2013
Bacterial modulation of early clearing responses and its effect on infectious disease outcome
Knut and Alice Wallenberg Foundation
1 January 2011 - 1 January 2016
Development of MHC class I-binding super-peptides for cancer vaccines
Swedish Research Council
1 January 2011 - 31 December 2013

Anställningar

Professor, Medicin, Solna, Karolinska Institutet, 2015-

Examina och utbildning

Docent, Immunologi, Karolinska Institutet, 2007
MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2001

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