Sophia Schedin Weiss forskargrupp

Publikationer

Alla gruppmedlemmars publikationer

• Journal article: NEUROBIOLOGY OF DISEASE. 2025;216:107129

  Altered APP trafficking drives amyloidogenic processing in primary neurons from the AppNL-F knock-in mouse model of Alzheimer's disease

  Yu Y; Zhou RZ; Nilsson P; Winblad B; Tjernberg LO; Schedin-Weiss S
• Article: ALZHEIMERS & DEMENTIA. 2025;21(3):e70091

  Intraneuronal Aβ accumulation causes tau hyperphosphorylation via endolysosomal leakage

  Gao Y; Wang L; Doeswijk T; Winblad B; Schedin-Weiss S; Tjernberg LO
• Review: ALZHEIMERS & DEMENTIA. 2025;21(3):e70048

  Tau degradation in Alzheimer's disease: Mechanisms and therapeutic opportunities

  Wang L; Sooram B; Kumar R; Schedin-Weiss S; Tjernberg LO; Winblad B
• Article: EBIOMEDICINE. 2025;113:105598

  Blood N-glycomics reveals individuals at risk for cognitive decline and Alzheimer's disease

  Zhou RZ; Gaunitz S; Kirsebom B-E; Lundin B; Hellstroem M; Jejcic A; Skoeldunger A; Wimo A; Winblad B; Fladby T; Schedin-Weiss S; Tjernberg LO
• Journal article: ADVANCED TECHNOLOGY IN NEUROSCIENCE. 2024;1(2):177-187

  A closer look at pathogenic amyloid-β in Alzheimer’s disease using cryo-electron microscopy: a narrative review

  Gao Y; Schedin-Weiss S; Tjernberg LO
• Article: BRAIN COMMUNICATIONS. 2024;6(6):fcae371

  A glycan biomarker predicts cognitive decline in amyloid- and tau-negative patients

  Zhou RZ; Duell F; Axenhus M; Joensson L; Winblad B; Tjernberg LO; Schedin-Weiss S
• Journal article: JOURNAL OF NEUROCHEMISTRY. 2024;168(9):3250-3267

  Targeting the PAC1 receptor mitigates degradation of myelin and synaptic markers and diminishes locomotor deficits in the cuprizone demyelination model

  Jansen MI; Mahmood Y; Lee J; Broome ST; Waschek JA; Castorina A
• Article: JOURNAL OF ALZHEIMERS DISEASE. 2024;100(s1):S93-S101

  Bisecting N-Acetylglucosamine Correlates with Phospho-Tau181 in Subjective Cognitive Decline but not in Control Cases

  Arulf SE; Zhou RZ; Kirsebom B-E; Jejcic A; Fladby T; Winblad B; Tjernberg L; Schedin-Weiss S
• Preprint: BIORXIV. 2024

  Hippocampal neuroinflammation causes sex-specific disruptions in action selection, food approach memories, and neuronal activation

  Ganesan K; Ghorbanpour S; Kendall W; Broome ST; Gladding J; Dhungana A; Abiero AR; Mahmoudi M; Castorina A; Kendig M; Becchi S; Valova V; Cole L; Bradfield L
• Journal article: VISUAL JOURNAL OF EMERGENCY MEDICINE. 2024;35:101982

  Urothelial carcinoma, a rare cause of gross haematuria

  Zhou RZ; Koh SH
• Journal article: VISUAL JOURNAL OF EMERGENCY MEDICINE. 2024;35:101983

  Haemoperitoneum from spontaneous anterior epiploic artery haemorrhage

  Zhou RZ; Koh SH
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(7):3622

  DEAD Box Helicase 24 Is Increased in the Brain in Alzheimer's Disease and App^N-LF Mice and Influences Presymptomatic Pathology

  Axenhus M; Doeswijk T; Nilsson P; Matton A; Winblad B; Tjernberg L; Schedin-Weiss S
• Article: BMC PUBLIC HEALTH. 2024;24(1):823

  The impact of the COVID-19 pandemic on neurosurgery in the elderly population in Sweden

  Axenhus M; Schedin-Weiss S; Tjernberg L; Winblad B
• Journal article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2024;17:11786469241248287

  A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease

  Summers BS; Broome ST; Pang TWR; Mundell HD; Belic NK; Tom NC; Ng ML; Yap M; Sen MK; Sedaghat S; Weible MW; Castorina A; Lim CK; Lovelace MD; Brew BJ
• Editorial: JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE. 2024;11(4):895-896

  On the 2024 Alzheimer's Association Criteria: Still Not Ready for Clinical Use

  Zhou RZ; Wimo A; Winblad B
• Journal article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2023;73(9-10):724-737

  Early Alterations of PACAP and VIP Expression in the Female Rat Brain Following Spinal Cord Injury

  Broome ST; Mandwie M; Gorrie CA; Musumeci G; Marzagalli R; Castorina A
• Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(13):11118

  Altered Hippocampal and Striatal Expression of Endothelial Markers and VIP/PACAP Neuropeptides in a Mouse Model of Systemic Lupus Erythematosus

  Lee J; Broome ST; Jansen MI; Mandwie M; Logan GJ; Marzagalli R; Musumeci G; Castorina A
• Article: ALZHEIMERS & DEMENTIA. 2023;19(7):3244-3249

  A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status

  Zhou RZ; Vetrano DL; Grande G; Duell F; Jonsson L; Laukka EJ; Fredolini C; Winblad B; Tjernberg L; Schedin-Weiss S
• Article: ALZHEIMERS RESEARCH & THERAPY. 2022;14(1):196

  Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer's disease brain extracts

  Sandberg A; Berenjeno-Correa E; Rodriguez RC; Axenhus M; Weiss SS; Batenburg K; Hoozemans JJM; Tjernberg LO; Scheper W
• Review: BMC GERIATRICS. 2022;22(1):878

  The impact of the COVID-19 pandemic on mortality in people with dementia without COVID-19: a systematic review and meta-analysis

  Axenhus M; Frederiksen KS; Zhou RZ; Waldemar G; Winblad B
• Journal article: CURRENT ISSUES IN MOLECULAR BIOLOGY. 2022;44(10):4500-4516

  Pro-Inflammatory and Pro-Apoptotic Effects of the Non-Protein Amino Acid L-Azetidine-2-Carboxylic Acid in BV2 Microglial Cells

  Piper JA; Jansen MI; Broome ST; Rodgers KJ; Musumeci G; Castorina A
• Journal article: BIOMEDICINES. 2022;10(8):1942

  Characterization of Mesothelin Glycosylation in Pancreatic Cancer: Decreased Core Fucosylated Glycoforms in Pancreatic Cancer Patients' Sera

  Duran A; Guerrero PE; Ortiz MR; Del Campo DP; Castro E; Garcia-Velasco A; Fort E; de Llorens R; Saldova R; Llop E; Peracaula R
• Journal article: EUROPEAN MEDICAL JOURNAL NEUROLOGY. 2022;10(1):29-30

  Huntingtin as a Presymptomatic Regulator of Alzheimer’s Disease

  Axenhus M; Schedin-Weiss S; Nilsson P; Winblad B; Tjernberg L
• Article: SCANDINAVIAN JOURNAL OF PUBLIC HEALTH. 2022;50(6):748-755

  Changes in mortality trends amongst common diseases during the COVID-19 pandemic in Sweden

  Axenhus M; Schedin-Weiss S; Winblad B; Wimo A
• Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:68-69

  Huntingtin as a presymptomatic regulator of Alzheimer's disease

  Axenhus M; Schedin-Weiss S; Nilsson P; Winblad B; Tjernberg L
• Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:74

  The COVID-19 pandemic has caused large disruptions to dementia mortality, care, and diagnosis in Sweden during 2020

  Winblad B; Schedin-Weiss S; Tjernberg L; Wimo A; Bucht G; Eriksdotter M; Axenhus M
• Article: GLYCOBIOLOGY. 2022;32(6):506-517

  Lack of N-glycosylation increases amyloidogenic processing of the amyloid precursor protein

  Lin T; van Husen LS; Yu Y; Tjernberg LO; Schedin-Weiss S
• Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(9):4788

  Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis

  Jansen MI; Thomas Broome S; Castorina A
• Article: BMC GERIATRICS. 2022;22(1):365

  Changes in dementia diagnoses in Sweden during the COVID-19 pandemic

  Axenhus M; Schedin-Weiss S; Tjernberg L; Wimo A; Eriksdotter M; Bucht G; Winblad B
• Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(3):1845

  The Anxiolytic Drug Buspirone Prevents Rotenone-Induced Toxicity in a Mouse Model of Parkinson's Disease

  Thomas Broome S; Castorina A
• Article: SCIENTIFIC DATA. 2021;8(1):312

  Insights into the changes in the proteome of Alzheimer disease elucidated by a meta-analysis

  Haytural H; Benfeitas R; Schedin-Weiss S; Bereczki E; Rezeli M; Unwin RD; Wang X; Dammer EB; Johnson ECB; Seyfried NT; Winblad B; Tijms BM; Visser PJ; Frykman S; Tjernberg LO
• Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:735334

  Microdissected Pyramidal Cell Proteomics of Alzheimer Brain Reveals Alterations in Creatine Kinase B-Type, 14-3-3-γ, and Heat Shock Cognate 71

  Sandebring-Matton A; Axenhus M; Bogdanovic N; Winblad B; Schedin-Weiss S; Nilsson P; Tjernberg LO
• Journal article: CHEMBIOCHEM. 2021;22(22):3108

  Cover Feature: Engineered Human Induced Pluripotent Cells Enable Genetic Code Expansion in Brain Organoids (ChemBioChem 22/2021)

  van Husen LS; Katsori A; Meineke B; Tjernberg LO; Schedin‐Weiss S; Elsässer SJ
• Article: CHEMBIOCHEM. 2021;22(22):3208-3213

  Engineered Human Induced Pluripotent Cells Enable Genetic Code Expansion in Brain Organoids

  van Husen LS; Katsori A-M; Meineke B; Tjernberg LO; Schedin-Weiss S; Elsasser SJ
• Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(20):10947

  PACAP and VIP Modulate LPS-Induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells

  Karunia J; Niaz A; Mandwie M; Thomas Broome S; Keay KA; Waschek JA; Al-Badri G; Castorina A
• Article: JOURNAL OF NEUROCHEMISTRY. 2021;159(2):292-304

  The N-glycan profile in cortex and hippocampus is altered in Alzheimer disease

  Gaunitz S; Tjernberg LO; Schedin-Weiss S
• Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;83(2):833-852

  A Super-Resolved View of the Alzheimer's Disease-Related Amyloidogenic Pathway in Hippocampal Neurons

  Yu Y; Gao Y; Winblad B; Tjernberg L; Weiss SS
• Preprint: PREPRINTS.ORG. 2021

  PACAP and VIP Modulate LPS-induced Microglial Activation and Trigger Distinct Phenotypic Changes in Murine BV2 Microglial Cells

  Karunia J; Niaz A; Mandwie M; Thomas Broome S; Keay K; Waschek J; Al-Badri G; Castorina A
• Journal article: APPLIED SCIENCES-BASEL. 2021;11(16):7673

  Doxycycline and Minocycline Act as Positive Allosteric Modulators of the PAC1 Receptor and Induce Plasminogen Activators in RT4 Schwann Cells

  Broome ST; Musumeci G; Castorina A
• Preprint: PREPRINTS.ORG. 2021

  Doxycycline and Minocycline act as Positive Allosteric Modulators of the PAC1 Receptor and Induce Plasminogen Activators in RT4 Schwann Cells

  Thomas Broome S; Musumeci G; Castorina A
• Review: BIOMEDICINES. 2021;9(7):801

  Neuronal Trafficking of the Amyloid Precursor Protein-What Do We Really Know?

  Lin T; Tjernberg LO; Schedin-Weiss S
• Preprint: BIORXIV. 2021

  Engineered human induced pluripotent cells enable genetic code expansion in brain organoids

  van Husen L; Katsori A-M; Meineke B; Tjernberg L; Schedin-Weiss S; Elsässer S
• Review: BIOMOLECULES. 2021;11(6):858

  What Can N-glycomics and N-glycoproteomics of Cerebrospinal Fluid Tell Us about Alzheimer Disease?

  Gaunitz S; Tjernberg LO; Schedin-Weiss S
• Journal article: CELLS. 2021;10(6):1312

  Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells

  Thomas Broome S; Fisher T; Faiz A; Keay KA; Musumeci G; Al-Badri G; Castorina A
• Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4530

  Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons

  Gao Y; Wennmalm S; Winblad B; Schedin-Weiss S; Tjernberg LO
• Preprint: PREPRINTS.ORG. 2021

  Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons

  Gao Y; Wennmalm S; Winblad B; Schedin-Weiss S; Tjernberg L
• Journal article: JOURNAL OF PROTEOMICS. 2021;231:104004

  Microfibril associated protein 4 (MFAP4) is a carrier of the tumor associated carbohydrate sialyl-Lewis x (sLe^x) in pancreatic adenocarcinoma

  Enrique Guerrero P; Duran A; Rosa Ortiz M; Castro E; Garcia-Velasco A; Llop E; Peracaula R
• Article: CURRENT ALZHEIMER RESEARCH. 2021;17(9):858-867

  Huntingtin Levels arc Elevated in Hippocampal Post-Mortem Samples of Alzheimer's Disease Brain

  Axenhus M; Winblad B; Tjernberg LO; Schedin-Weiss S
• Journal article: NEURAL REGENERATION RESEARCH. 2020;15(12):2173

  Dopamine: an immune transmitter

  Broome ST; Louangaphay K; Keay KA; Leggio GM; Musumeci G; Castorina A
• Journal article: SCIENTIFIC REPORTS. 2020;10(1):18974

  Characterisation of the main PSA glycoforms in aggressive prostate cancer

  Gratacos-Mulleras A; Duran A; Shehni AA; Ferrer-Batalle M; Ramirez M; Comet J; de Llorens R; Saldova R; Llop E; Peracaula R
• Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2020;1867(9):118737

  Brain-derived neurotrophic factor (BDNF) promotes molecular polarization and differentiation of immature neuroblastoma cells into definitive neurons

  Hromadkova L; Bezdekova D; Pala J; Schedin-Weiss S; Tjernberg LO; Hoschl C; Ovsepian SV
• Article: FEBS JOURNAL. 2020;287(15):3221-3234

  Glycan biomarkers for Alzheimer disease correlate with T-tau and P-tau in cerebrospinal fluid in subjective cognitive impairment

  Schedin-Weiss S; Gaunitz S; Sui P; Chen Q; Haslam SM; Blennow K; Winblad B; Dell A; Tjernberg LO
• Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;75(1):321-335

  Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ₄₂-Induced Pathways to Alzheimer's Disease Pathology

  Schedin-Weiss S; Nilsson P; Sandebring-Matton A; Axenhus M; Sekiguchi M; Saito T; Winblad B; Saido T; Tjernberg LO
• Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;72(2):537-548

  Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products

  van Husen LS; Schedin-Weiss S; Minh NT; Kazmi MA; Winblad B; Sakmar TP; Elsaesser SJ; Tjernberg LO
• Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(3):2103-2114

  Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen

  Bonito-Oliva A; Schedin-Weiss S; Younesi SS; Tiiman A; Adura C; Paknejad N; Brendel M; Romin Y; Parchem RJ; Graff C; Vukojevic V; Tjernberg LO; Terenius L; Winblad B; Sakmar TP; Graham WV
• Journal article: US NEUROLOGY. 2019;15(1):14

  Molecular Pathogenesis of Alzheimer’s Disease

  Tjernberg L; Associate Professor at the Department of Neurobiol CSAS; Weiss SS
• Journal article: WORLD JOURNAL OF GASTROENTEROLOGY. 2018;24(24):2537-2554

  Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma

  Llop E; Guerrero PE; Duran A; Barrabes S; Massaguer A; Jose Ferri M; Albiol-Quer M; de Llorens R; Peracaula R
• Article: LIFE SCIENCE ALLIANCE. 2018;1(3):e201800028

  Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapses

  Yu Y; Jans DC; Winblad B; Tjernberg LO; Schedin-Weiss S
• Journal article: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2018;112:33-45

  Analysis of sialyl-Lewis x on MUC5AC and MUC1 mucins in pancreatic cancer tissues

  Balmana M; Duran A; Gomes C; Llop E; Lopez-Martos R; Rosa Ortiz M; Barrabes S; Reis CA; Peracaula R
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(52):21623-21630

  Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4

  Peeler JC; Schedin-Weiss S; Soula M; Kazmi MA; Sakmar TP
• Article: ALZHEIMERS RESEARCH & THERAPY. 2017;9(1):57

  Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

  Schedin-Weiss S; Inoue M; Hromadkova L; Teranishi Y; Yamamoto NG; Wiehager B; Bogdanovic N; Winblad B; Sandebring-Matton A; Frykman S; Tjernberg LO
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;483(1):352-358

  Maturation and processing of the amyloid precursor protein is regulated by the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2)

  Frykman S; Inoue M; Ikeda A; Teranishi Y; Kihara T; Lundgren JL; Yamamoto NG; Bogdanovic N; Winblad B; Schedin-Weiss S; Tjernberg LO
• Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2016;4:29

  Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse

  Schedin-Weiss S; Caesar I; Winblad B; Blom H; Tjernberg LO
• Article: MOLECULAR NEUROBIOLOGY. 2015;52(3):1077-1092

  Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells

  Lucotte B; Tajhizi M; Alkhatib D; Samuelsson E-B; Wiehager B; Schedin-Weiss S; Sundstrom E; Winblad B; Tjernberg LO; Behbahani H
• Article: JOURNAL OF NEUROCHEMISTRY. 2015;135(3):606-615

  ADAM10 and BACE1 are localized to synaptic vesicles

  Lundgren JL; Ahmed S; Schedin-Weiss S; Gouras GK; Winblad B; Tjernberg LO; Frykman S
• Article: FEBS JOURNAL. 2015;282(17):3438-3451

  Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Ab production without affecting Notch cleavage

  Teranishi Y; Inoue M; Yamamoto NG; Kihara T; Wiehager B; Ishikawa T; Winblad B; Schedin-Weiss S; Frykman S; Tjernberg LO
• Journal article: ALZHEIMERS & DEMENTIA. 2015;11(7S_Part_8):p363-p364

  P1‐065: Adam10 and bace1 are localized to synaptic vesicles

  Winblad B; Lundgren J; Ahmed S; Schedin-Weiss S; Gouras GK; Tjernberg LO; Frykman S
• Article: FEBS JOURNAL. 2015;282(14):2587-2599

  Human brain proteins showing neuron-specific interactions with γ-secretase

  Inoue M; Hur J-Y; Kihara T; Teranishi Y; Yamamoto NG; Ishikawa T; Wiehager B; Winblad B; Tjernberg LO; Schedin-Weiss S
• Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_12):p491

  P2‐058: A GLYCOMICS APPROACH FOR ANALYZING CEREBROSPINAL FLUID

  Gaunitz S; Schedin‐Weiss S; Winblad B; Tjernberg L
• Review: FEBS JOURNAL. 2014;281(1):46-62

  The role of protein glycosylation in Alzheimer disease.

  Schedin-Weiss S; Winblad B; Tjernberg LO
• Article: PLOS ONE. 2013;8(5):e63962

  Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation - Application on γ-Secretase

  Schedin-Weiss S; Inoue M; Teranishi Y; Yamamoto NG; Karlstrom H; Winblad B; Tjernberg LO
• Article: NEUROCHEMISTRY INTERNATIONAL. 2012;61(1):108-118

  Identification of two novel synaptic γ-secretase associated proteins that affect amyloid β-peptide levels without altering Notch processing

  Frykman S; Teranishi Y; Hur J-Y; Sandebring A; Yamamoto NG; Ankarcrona M; Nishimura T; Winblad B; Bogdanovic N; Schedin-Weiss S; Kihara T; Tjernberg LO
• Article: PLOS ONE. 2012;7(1):e29586

  Meningococcal outer membrane protein NhhA triggers apoptosis in macrophages.

  Sjölinder M; Altenbacher G; Hagner M; Sun W; Schedin-Weiss S; Sjölinder H
• Article: MOLECULAR & CELLULAR PROTEOMICS. 2012;11(1):M111.008730

  Tumor biomarker glycoproteins in the seminal plasma of healthy human males are endogenous ligands for DC-SIGN.

  Clark GF; Grassi P; Pang P-C; Panico M; Lafrenz D; Drobnis EZ; Baldwin MR; Morris HR; Haslam SM; Schedin-Weiss S; Sun W; Dell A
• Article: PLOS ONE. 2011;6(12):e29011

  N-glycans of human protein C inhibitor: tissue-specific expression and function.

  Sun W; Grassi P; Engström A; Sooriyaarachchi S; Ubhayasekera W; Hreinsson J; Wånggren K; Clark GF; Dell A; Schedin-Weiss S
• Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2010;504(2):169-176

  Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes.

  Schedin-Weiss S; Richard B; Olson ST
• Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;403(2):198-202

  Further insight into the roles of the glycans attached to human blood protein C inhibitor.

  Sun W; Parry S; Ubhayasekera W; Engström A; Dell A; Schedin-Weiss S
• Review: BIOCHIMIE. 2010;92(11):1587-1596

  Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors.

  Olson ST; Richard B; Izaguirre G; Schedin-Weiss S; Gettins PGW
• Article: THROMBOSIS AND HAEMOSTASIS. 2010;104(3):544-553

  Zinc ions bind to and inhibit activated protein C.

  Zhu T; Ubhayasekera W; Nickolaus N; Sun W; Tingsborg S; Mowbray SL; Schedin-Weiss S
• Article: RETROVIROLOGY. 2010;7:20

  GPG-NH₂ acts via the metabolite αHGA to target HIV-1 Env to the ER-associated protein degradation pathway

  Jejcic A; Hoglund S; Vahlne A
• Article: JOURNAL OF VIROLOGY. 2009;83(19):10075-10084

  Small Molecule Targets Env for Endoplasmic Reticulum-Associated Protein Degradation and Inhibits Human Immunodeficiency Virus Type 1 Propagation

  Jejcic A; Daniels R; Goobar-Larsson L; Hebert DN; Vahlne A
• Article: BIOCHEMISTRY. 2009;48(5):1094-1098

  Heparin enhances the inhibition of factor Xa by protein C inhibitor in the presence but not in the absence of Ca2+.

  Sun W; Eriksson AS; Schedin-Weiss S
• Article: BIOCHEMISTRY. 2008;47(51):13610-13619

  Antiangiogenic forms of antithrombin specifically bind to the anticoagulant heparin sequence.

  Schedin-Weiss S; Richard B; Hjelm R; Olson ST
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(27):18601-18611

  N-glycans and the N terminus of protein C inhibitor affect the cofactor-enhanced rates of thrombin inhibition.

  Sun W; Parry S; Panico M; Morris HR; Kjellberg M; Engström A; Dell A; Schedin-Weiss S
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(21):14417-14429

  Characterization of the conformational alterations, reduced anticoagulant activity, and enhanced antiangiogenic activity of prelatent antithrombin.

  Richard B; Swanson R; Schedin-Weiss S; Ramirez B; Izaguirre G; Gettins PGW; Olson ST
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1771(4):506-513

  Defect in fatty acid esterification of dolichol in Niemann-Pick type C1 mouse livers in vivo.

  Turunen M; Schedin-Weiss S
• Article: BIOCHEMISTRY. 2007;46(11):3378-3384

  High affinity interaction between a synthetic, highly negatively charged pentasaccharide and alpha- or beta-antithrombin is predominantly due to nonionic interactions.

  Hjelm R; Schedin-Weiss S
• Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2005;49(1):40-44

  Glycine-amide is an active metabolite of the antiretroviral tripeptide glycyl-prolyl-glycine-amide

  Andersson E; Horal P; Jejcic A; Höglund S; Balzarini J; Vahlne A; Svennerholm B
• Article: BIOCHEMISTRY. 2004;43(3):675-683

  Roles of N-terminal region residues Lys11, Arg13, and Arg24 of antithrombin in heparin recognition and in promotion and stabilization of the heparin-induced conformational change.

  Schedin-Weiss S; Desai UR; Bock SC; Olson ST; Björk I
• Article: BIOCHEMISTRY. 2002;41(41):12369-12376

  Specificity of the basic side chains of Lys114, Lys125, and Arg129 of antithrombin in heparin binding.

  Schedin-Weiss S; Arocas V; Bock SC; Olson ST; Björk I
• Article: BIOCHEMISTRY. 2002;41(15):4779-4788

  Importance of lysine 125 for heparin binding and activation of antithrombin.

  Schedin-Weiss S; Desai UR; Bock SC; Gettins PGW; Olson ST; Björk I
• Article: JOURNAL OF HUMAN VIROLOGY. 2001;4(1):8-15

  The tripeptide glycyl-prolyl-glycine amide does not affect the early steps of the human immunodeficiency virus type 1 replication

  Su J; Naghavi MH; Jejcic A; Horal P; Furuta Y; Wu YP; Li SL; Hall WW; Goobar-Larsson L; Svennerholm B; Vahlne A
• Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;297(3):607-614

  Influence of peroxisome proliferator-activated receptor alpha on ubiquinone biosynthesis.

  Turunen M; Peters JM; Gonzalez FJ; Schedin S; Dallner G
• Article: JOURNAL OF GENERAL VIROLOGY. 1998;79:2929-2937

  Characterization of three co-circulating genotypes of the small hydrophobic protein gene of mumps virus

  Tecle T; Johansson B; Jejcic A; Forsgren M; Orvell C
• Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1998;1394(2-3):177-186

  Alterations in the biosynthesis of cholesterol, dolichol and dolichyl-P in the genetic cholesterol homeostasis disorder, Niemann-Pick type C disease.

  Schedin S; Nilsson M; Chojnacki T; Dallner G
• Article: BIOCHEMICAL PHARMACOLOGY. 1998;56(9):1195-1199

  Reduced cholesterol accumulation and improved deficient peroxisomal functions in a murine model of Niemann-Pick type C disease upon treatment with peroxisomal proliferators

  Schedin S; Pentchev P; Dallner G
• Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(10):6245-6251

  Peroxisomal impairment in Niemann-Pick type C disease

  Schedin S; Sindelar PJ; Pentchev P; Brunk U; Dallner G
• Article: JOURNAL OF NEUROCHEMISTRY. 1995;65(2):670-676

  CHANGES IN THE LEVELS OF DOLICHOL AND DOLICHYL-PHOSPHATE IN A MURINE MODEL OF NIEMANN-PICKS TYPE-C DISEASE

  SCHEDIN S; PENTCHEV PG; BRUNK U; DALLNER G
• Article: CARCINOGENESIS. 1995;16(3):599-605

  ENZYMES OF THE MEVALONATE PATHWAY IN RAT-LIVER NODULES INDUCED BY 2-ACETYLAMINOFLUORENE TREATMENT

  OLSSON JM; SCHEDIN S; TECLEBRHAN H; ERIKSSON LC; DALLNER G
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Gruppledare

• 

  Sophia Schedin Weiss

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  Telefon +46852483507

  E-postadress sophia.schedin.weiss@ki.se

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• Tosca Doeswijk

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  Adrià Duran Sidera

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• Ella Hammer

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• Alenka Jejcic

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• 

  Sophia Schedin Weiss

  Forskare | Docent

  Telefon +46852483507

  E-postadress sophia.schedin.weiss@ki.se
• Sarah Thomas Broome

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  E-postadress sarah.thomas.broome@ki.se
• Oskar Widström

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  E-postadress oskar.widstrom@ki.se
• 

  Robin Zhou

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  E-postadress robin.zhou@ki.se