Andreas Lundqvists forskargrupp

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Tumörimmunologi

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Gruppmedlemmar

Andreas Lundqvist, gruppledare
Veronika Kremer, doktorand
Kristina Witt, doktorand
Maria Wolodarski, doktorand
Ziqing Chen, doktorand
Shi Yong Neo, doktorand
Lisa Liu, post doc
Ying Yang, anknuten
Marie Murray, anknuten

Alumni

Erik Wennerberg, Weill Cornell Medicine, New York

Dhifaf Sarhan, University of Minnesota and Karolinska Institutet

Utvalda publikationer

Genetic engineering of human NK cells to express CXCR2 improves migration to renal cell carcinoma.
Kremer V, Ligtenberg M, Zendehdel R, Seitz C, Duivenvoorden A, Wennerberg E, et al
J Immunother Cancer 2017 Sep;5(1):73

Zoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer.
Sarhan D, Leijonhufvud C, Murray S, Witt K, Seitz C, Wallerius M, et al
Oncoimmunology 2017 ;6(8):e1338238

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.
Mao Y, van Hoef V, Zhang X, Wennerberg E, Lorent J, Witt K, et al
Blood 2016 09;128(11):1475-89

Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β.
Sarhan D, Palma M, Mao Y, Adamson L, Kiessling R, Mellstedt H, et al
Eur. J. Immunol. 2015 Jun;45(6):1783-93

CXCL10-induced migration of adoptively transferred human natural killer cells toward solid tumors causes regression of tumor growth in vivo.
Wennerberg E, Kremer V, Childs R, Lundqvist A
Cancer Immunol. Immunother. 2015 Feb;64(2):225-35

Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.
Wennerberg E, Pfefferle A, Ekblad L, Yoshimoto Y, Kremer V, Kaminskyy V, et al
Clin. Cancer Res. 2014 Nov;20(22):5733-44

Inhibition of tumor-derived prostaglandin-e2 blocks the induction of myeloid-derived suppressor cells and recovers natural killer cell activity.
Mao Y, Sarhan D, Steven A, Seliger B, Kiessling R, Lundqvist A
Clin. Cancer Res. 2014 Aug;20(15):4096-106

A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells.
Sarhan D, Wennerberg E, D'Arcy P, Gurajada D, Linder S, Lundqvist A
Cancer Immunol. Immunother. 2013 Aug;62(8):1359-68

Doxorubicin sensitizes human tumor cells to NK cell- and T-cell-mediated killing by augmented TRAIL receptor signaling.
Wennerberg E, Sarhan D, Carlsten M, Kaminskyy V, D'Arcy P, Zhivotovsky B, et al
Int. J. Cancer 2013 Oct;133(7):1643-52

Activated monocytes augment TRAIL-mediated cytotoxicity by human NK cells through release of IFN-γ.
Sarhan D, D'Arcy P, Wennerberg E, Lidén M, Hu J, Winqvist O, et al
Eur. J. Immunol. 2013 Jan;43(1):249-57

Lista med alla publikationer.

Finansiering

  • Swedish Cancer Society
  • European Research Council
  • The Cancer Research Foundations of Radiumhemmet
  • The Swedish Childhood Cancer Foundation
  • Swedish Research Council
  • Karolinska Institutet
  • Jeanssons Stiftelse
  • Åke Wiberg Foundation
  • Magnus Bergvall Foundation
  • Fredrik och Ingrid Thurings Foundation
  • Clas Groschinskys Foundation
  • Swedish Society of Medicine
  • Wenner-Gren Foundation
  • The American Thyroid Association
  • Vinnova
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