Andreas Lundqvists forskargrupp
Tumörimmunologi
Mer information finns på den engelska sidan
Gruppmedlemmar
Andreas Lundqvist, gruppledare, professor
Neda Bigdeli, biomedicinsk analytiker
Mireia Cruz de los Santos, doktorand
Apple Tay, doktorand
Le Tong, doktorand
Lisa Liu, anknuten
Ying Yang, post doc
Alumni
Erik Wennerberg, The Institute of Cancer Research, London
Dhifaf Sarhan, Karolinska Institutet
Veronika Kremer, Novartis
Kristina Witt, Oncopeptides
Maria Wolodarski, Karolinska universitetssjukhuset
Ziqing Chen, Princeton University
Shi Yong Neo, Agency for Science, Technology and Research (A*STAR), Singapore
Khang Luu, National University of Singapore
Utvalda publikationer
Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells.
Neo SY, Jing X, Tong L, Tong D, Gao J, Chen Z, De Los Santos MC, Burduli N, De Souza Ferreira S, Wagner AK, Alici E, Rolny C, Cao Y, Lundqvist A
J Immunother Cancer 2022 Oct;10(10):
A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models.
Tay AHM, Prieto-Díaz R, Neo S, Tong L, Chen X, Carannante V, Önfelt B, Hartman J, Haglund F, Majellaro M, Azuaje J, Garcia-Mera X, Brea JM, Loza MI, Jespers W, Gutierrez-de-Teran H, Sotelo E, Lundqvist A
J Immunother Cancer 2022 May;10(5):
B7-H7 Is Inducible on T Cells to Regulate Their Immune Response and Serves as a Marker for Exhaustion.
Luu K, Schwarz H, Lundqvist A
Front Immunol 2021 ;12():682627
Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25+ /CD54+ NK cells.
Chen Z, Yang Y, Neo SY, Shi H, Chen Y, Wagner AK, Larsson K, Tong L, Jakobsson PJ, Alici E, Wu J, Cao Y, Wang K, Liu LL, Mao Y, Sarhan D, Lundqvist A
EMBO Rep 2021 Jan;():e51329
Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells.
Yang Y, Neo SY, Chen Z, Cui W, Chen Y, Guo M, Wang Y, Xu H, Kurzay A, Alici E, Holmgren L, Haglund F, Wang K, Lundqvist A
J Clin Invest 2020 10;130(10):5508-5522
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment.
Neo SY, Yang Y, Record J, Ma R, Chen X, Chen Z, Tobin NP, Blake E, Seitz C, Thomas R, Wagner AK, Andersson J, de Boniface J, Bergh J, Murray S, Alici E, Childs R, Johansson M, Westerberg LS, Haglund F, Hartman J, Lundqvist A
J Clin Invest 2020 03;130(3):1185-1198
Genetic engineering of human NK cells to express CXCR2 improves migration to renal cell carcinoma.
Kremer V, Ligtenberg MA, Zendehdel R, Seitz C, Duivenvoorden A, Wennerberg E, Colón E, Scherman-Plogell AH, Lundqvist A
J Immunother Cancer 2017 09;5(1):73
Zoledronic acid inhibits NFAT and IL-2 signaling pathways in regulatory T cells and diminishes their suppressive function in patients with metastatic cancer.
Sarhan D, Leijonhufvud C, Murray S, Witt K, Seitz C, Wallerius M, Xie H, Ullén A, Harmenberg U, Lidbrink E, Rolny C, Andersson J, Lundqvist A
Oncoimmunology ;6(8):e1338238
IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.
Mao Y, van Hoef V, Zhang X, Wennerberg E, Lorent J, Witt K, Masvidal L, Liang S, Murray S, Larsson O, Kiessling R, Lundqvist A
Blood 2016 09;128(11):1475-89
Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β.
Sarhan D, Palma M, Mao Y, Adamson L, Kiessling R, Mellstedt H, Österborg A, Lundqvist A
Eur J Immunol 2015 Jun;45(6):1783-93
Finansiering
- Cancerfonden
- Radiumhemmets forskningsfonder
- Barncancerfonden
- Vetenskapsrådet