Herlenius Research
Development of autonomic control
Immature or deficient autonomic control is a common problem in infants born at a premature age and is of central importance in apneas, secondary hypoxic brain damage and sudden infant death syndrome.
Eric Herlenius
Research group leaderFor better understanding of disturbances in respiratory control we study early development of cardiorespiratory control, brainstem neural networks and it's associations with normal and pathological breathing. The conceptual change introduced by our recent data that endogenous prostaglandins are central pathogenic factors in respiratory disorders and the hypoxic response, open new diagnostic and therapeutic avenues that should significantly better the diagnostics and treatment of newborns and adult patients.
Inflammation is a major culprit in breathing disorders and we hypothesize that by using a newly developed urinary prostaglandin biomarker we can screen, detect and protect against inflammation related breathing disorders.
Our collaborative efforts enable us to move from a clinical problem to molecular understanding of the disease and studies are performed in patients, animal & in vitro models.
Our research is focused on the development of autonomic control with normal and paediatric patients as the target. Autonomic dysfunction in breathing and circulatory control often has its origin in neurodevelopment disorders. Furthermore, our basic research in developmental neuroscience how neural activity and stem cells form activity dependent networks is vital for the development of therapeutic interventions.
Group members
David Forsberg
Anknuten till ForskningKerstin Jost
Anknuten till ForskningSusanne Rautiainen Lagerström
ForskningsspecialistBirgitta Böhm
Senior researcher Ph.D.Yuri Shvarev
Senior researcher Ph.D.Athina Samara
Anknuten till ForskningWiktor Phillips
Postdoc, Ph.D.Antoine Honoré
M.Sc., Ph.D. studentJan Reising
M.Sc., Ph.D. studentLouise Steinhoff
MD, Ph.D. studentNaify Ramadan
M.Sc., Ph.D. studentMargareta Eriksson
Anknuten till ForskningNiklas Lidströmer
Anknuten till ForskningRutger Bennet
Anknuten till ForskningKarin Pukk Härenstam
Anknuten till Undervisning/handledningRuth Löllgen
Anknuten till ForskningAlexander Rakow
Anknuten till ForskningKatja Adolphson
Anknuten till ForskningFrida Sundemo
Rami Asfar
Matilda Hellberg
Alexander Stålhammar
Emma Persad
Karen Coste
Dissertations
Leifsdottir, Kristine, 2022-06-03
Biomarkers in cerebrospinal fluid of neonates at risk of brain injury
Hamrin, Johan, 2021-11-19
Viral respiratory tract infections in children
Forsberg, David, 2017-12-07
The breathing brainstem : development of inspiration
Siljehav, Veronica. 2014-11-07
Neonatal respiratory control - inspiration, inflammation and the prostaglandin E2 pathway
Jeongsook Park; 2012-01-20 (Licentiate)
Jäderstad, Linda; 2012-01-13
Stem cell interactions with the injured brain.
Zachi Horn; 2011-01-21
Cytoskeleton-interacting proteins in brainstem development.
Jäderstad, Johan; 2010-11-26
Neural stem cell engraftment: Functional interactions, brain repair and gap junctions.
Hofstetter-Olsson Annika; 2006-12-01
Apnea and infection in neonates: Mediatory role of interleukin-1b and prostaglandin E2
Saha, Sipra; 2006-06-14
mPGES-1: a key regulator of fever and neonatal respiratory depression
Links
Hjärnfonden: Vad innebär det för forskaren att få stöd av en donator?
Den livsviktiga andningen, P1:s Kropp & Själ 2018 (in Swedish)
"Eric Herlenius, professor i pediatrik", Interaktiv communication, 2014 (in Swedish)
"To Breathe or not to Breathe: Activity dependent development of Inspiration", Inspirational lecture: Professor Eric Herlenius, 2014
Stem cells rescue nerve cells by direct contact, KI News 2013