Eric Herlenius

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Nuvarande Position och Uppdrag:
Professor i Pediatrik, Karolinska Institutet
Överläkare i barnmedicin, Astrid Lindgrens barnsjukhus
Vice Ordf. Vetenskapsrådet beredningsgrupp MH-07: Kvinnor och Barns Hälsa 2021-2022
KI ansvarig Rekrytering ST-Pediatrik, Karolinska Universitets sjukhuset 2012-2022
FoUU-ansvarig vid Barnakut- och infektionssjukvård, Tema Barn- och Kvinnosjukvård, Karolinska universitetssjukhuset

Artiklar

Article: STAR PROTOCOLS. 2024;5(1):102908

Protocol to dissect and dissociate the mouse brainstem for single-cell RNA-seq applications

Phillips WS; Ramadan N; Samara A; Herlenius E
Article: NATURE COMMUNICATIONS. 2024;15(1):2186

Systematic review and meta-analysis for a Global Patient co-Owned Cloud (GPOC).

Lidströmer N; Davids J; ElSharkawy M; Ashrafian H; Herlenius E
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1408607

Astrocytic Calcium Signaling Toolkit (astroCaST): efficient analysis of dynamic astrocytic calcium events

Reising JP; Gonzalez-Sanchez AC; Samara A; Herlenius E
Article: ACTA PAEDIATRICA. 2023;112(7):1443-1452

Weight a minute: The smaller and more immature, the more predictable the autonomic regulation?

Stalhammar AM; Honore A; Adolphson K; Forsberg D; Herlenius E; Jost K
Article: ACTA PAEDIATRICA. 2023;112(4):686-696

Vital sign-based detection of sepsis in neonates using machine learning

Honore A; Forsberg D; Adolphson K; Chatterjee S; Jost K; Herlenius E
Article: FRONTIERS IN PEDIATRICS. 2023;11:1225294

Mechanical ventilation induces brainstem inflammation in preterm fetal sheep

Vidinopoulos K; Azman Z; Somers A; Zahra VA; Thiel A; Lu H; Pham Y; Tran NT; Allison BJ; Herlenius E; Hooper S; Galinsky R; Polglase GR
Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(8):1151-1161

Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function

Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Ottosson V; Forsberg D; Thorlacius GE; Biavati L; Strandberg L; Mofors J; Ramskold D; Ruhrmann S; Meneghel L; Nyberg W; Espinosa A; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
Article: ACTA PAEDIATRICA. 2022;111(5):961-970

Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study

Leifsdottir K; Thelin EP; Lassaren P; Siljehav V; Nilsson P; Eksborg S; Herlenius E
Article: FRONTIERS IN NEURAL CIRCUITS. 2022;16:826497

Prostaglandin E2 Exerts Biphasic Dose Response on the PreBotzinger Complex Respiratory-Related Rhythm

Reising JP; Phillips WS; Ramadan N; Herlenius E
Article: FRONTIERS IN PEDIATRICS. 2022;10:921444

The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome

Leifsdottir K; Jost K; Siljehav V; Thelin EP; Lassaren P; Nilsson P; Haraldsson A; Eksborg S; Herlenius E
Article: FRONTIERS IN PHYSIOLOGY. 2022;13:841229

Increased Prostaglandin E2 in Brainstem Respiratory Centers Is Associated With Inhibition of Breathing Movements in Fetal Sheep Exposed to Progressive Systemic Inflammation

Stojanovska V; Atta J; Kelly SB; Zahra VA; Matthews-Staindl E; Nitsos I; Moxham A; Pham Y; Hooper SB; Herlenius E; Galinsky R; Polglase GR
Article: ACTA PAEDIATRICA. 2021;110(10):2802-2804

Reduction in paediatric emergency visits during the COVID-19 pandemic in a region with open preschools and schools

Rhedin SA; Rinder MR; Hildenwall H; Herlenius E; Hertting O; Luthander J; Melen E; Nijman R; Olsson-Akefeldt S; Alfven T
Article: TRANSLATIONAL PSYCHIATRY. 2020;10(1):312

Presynaptic dysfunction inCASK-related neurodevelopmental disorders

Becker M; Mastropasqua F; Reising JP; Maier S; Ho M-L; Rabkina I; Li D; Neufeld J; Ballenberger L; Myers L; Moritz V; Kele M; Wincent J; Willfors C; Sitnikov R; Herlenius E; Anderlid B-M; Falk A; Bolte S; Tammimies K
Article: FRONTIERS IN PHYSIOLOGY. 2020;11:624625

Is There an Effect of Fetal Mesenchymal Stem Cells in the Mother-Fetus Dyad in COVID-19 Pregnancies and Vertical Transmission?

Samara A; Herlenius E
Article: ACTA PAEDIATRICA. 2019;108(10):1879-1886

Urinary PGE₂ metabolite levels in hospitalised infants with infections compared to age-matched controls

Hamrin J; Perez-Manzo M; Idborg H; Jakobsson P-J; Bjork L; Eriksson M; Nilsson A; Herlenius E
Article: FRONTIERS IN PHYSIOLOGY. 2019;10:307

Cognitive Development Trajectories in Preterm Children With Very Low Birth Weight Longitudinally Followed Until 11 Years of Age

Stalnacke SR; Tessma M; Bohm B; Herlenius E
Article: JOURNAL OF NEUROINFLAMMATION. 2018;15(1):223

Fas-ligand and interleukin-6 in the cerebrospinal fluid are early predictors of hypoxic-ischemic encephalopathy and long-term outcomes after birth asphyxia in term infants

Leifsdottir K; Mehmet H; Eksborg S; Herlenius E
Article: PEDIATRICS. 2018;141(5):e20174047

Neurobehavioral Outcomes 11 Years After Neonatal Caffeine Therapy for Apnea of Prematurity

Muerner-Lavanchy IM; Doyle LW; Schmidt B; Roberts RS; Asztalos EV; Costantini L; Davis PG; Dewey D; D'Ilario J; Grunau RE; Moddemann D; Nelson H; Ohlsson A; Solimano A; Tin W; Anderson PJ
Article: ELIFE. 2017;6:e29566

Astrocytes release prostaglandin E2 to modify respiratory network activity

Forsberg D; Ringstedt T; Herlenius E
Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2017;42:2D.13.1-2D.13.30

Functional Stem Cell Integration into Neural Networks Assessed by Organotypic Slice Cultures.

Forsberg D; Thonabulsombat C; Jäderstad J; Jäderstad LM; Olivius P; Herlenius E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(32):E6603-E6612

Rho-associated kinase is a therapeutic target in neuroblastoma

Dyberg C; Fransson S; Andonova T; Sveinbjornsson B; Lannerholm-Palm J; Olsen TK; Forsberg D; Herlenius E; Martinsson T; Brodin B; Kogner P; Johnsen JI; Wickstrom M
Article: JAMA PEDIATRICS. 2017;171(6):564-572

Academic Performance, Motor Function, and Behavior 11 Years After Neonatal Caffeine Citrate Therapy for Apnea of Prematurity An 11-Year Follow-up of the CAP Randomized Clinical Trial

Schmidt B; Roberts RS; Anderson PJ; Asztalos EV; Costantini L; Davis PG; Dewey D; D'Ilario J; Doyle LW; Grunau RE; Moddemann D; Nelson H; Ohlsson A; Solimano A; Tin W
Article: ELIFE. 2016;5:e14170

CO₂-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

Forsberg D; Horn Z; Tserga E; Smedler E; Silberberg G; Shvarev Y; Kaila K; Uhlen P; Herlenius E
Article: ARCHIVES DE PEDIATRIE. 2016;23(3):234-240

Hospital readmission after postpartum discharge of tern newborns in two maternity wards in Stockholm and Marseille

Boubred F; Herlenius E; Andres V; des Robert C; Marchini G
Article: JOURNAL OF PEDIATRICS. 2015;167(6):1207-13.e3

Prostaglandin E₂ Mediates Cardiorespiratory Disturbances during Infection in Neonates

Siljehav V; Hofstetter AM; Leifsdottir K; Herlenius E
Article: ACTA PAEDIATRICA. 2015;104(11):1077-1083

Extremely preterm infants who are small for gestational age have a high risk of early hypophosphatemia and hypokalemia

Boubred F; Herlenius E; Bartocci M; Jonsson B; Vanpee M
Article: JOURNAL OF PEDIATRICS. 2015;167(5):982-6.e2

Prediction of Late Death or Disability at Age 5 Years Using a Count of 3 Neonatal Morbidities in Very Low Birth Weight Infants

Schmidt B; Roberts RS; Davis PG; Doyle LW; Asztalos EV; Opie G; Bairam A; Solimano A; Arnon S; Sauve RS
Article: NEUROREPORT. 2015;26(15):928-936

Adult neural precursor cells form connexin-dependent networks that improve their survival

Ravella A; Ringstedt T; Brion J-P; Pandolfo M; Herlenius E
Article: ARCHIVES OF DISEASE IN CHILDHOOD. 2015;100(8):748-753

Predicting severe motor impairment in preterm children at age 5 years

Synnes A; Anderson PJ; Grunau RE; Dewey D; Moddemann D; Tin W; Davis PG; Doyle LW; Foster G; Khairy M; Nwaesei C; Schmidt B
Article: JOURNAL OF PEDIATRICS. 2015;166(4):870-6.e1-2-U158

Social Variables Predict Gains in Cognitive Scores across the Preschool Years in Children with Birth Weights 500 to 1250 Grams

Manley BJ; Roberts RS; Doyle LW; Schmidt B; Anderson PJ; Barrington KJ; Bohm B; Golan A; van Wassenaer-Leemhuis AG; Davis PG
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2014;91(6):269-275

Evaluation of urinary prostaglandin E₂ metabolite as a biomarker in infants with fever due to viral infection

Idborg H; Pawelzik S-C; Perez-Manso M; Bjork L; Hamrin J; Herlenius E; Jakobsson P-J
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2014;117(9):1027-1036

Il-1β and prostaglandin E₂ attenuate the hypercapnic as well as the hypoxic respiratory response via prostaglandin E receptor type 3 in neonatal mice

Siljehav V; Shvarev Y; Herlenius E
Article: JOURNAL OF PEDIATRICS. 2014;165(2):356-359.e2

Reduction in Developmental Coordination Disorder with Neonatal Caffeine Therapy

Doyle LW; Schmidt B; Anderson PJ; Davis PG; Moddemann D; Grunau RE; O'Brien K; Sankaran K; Herlenius E; Roberts R
Article: ACTA PAEDIATRICA. 2013;102(11):1041-1047

PGE₂ - metabolite levels in CSF correlate to HIE score and outcome after perinatal asphyxia

Bjork L; Leifsdottir K; Saha S; Herlenius E
Article: ACTA PAEDIATRICA. 2013;102(7):680-688

Unexpected collapse of healthy newborn infants: risk factors, supervision and hypothermia treatment

Pejovic NJ; Herlenius E
Article: TRANSLATIONAL STROKE RESEARCH. 2013;4(2):236-247

Sudden Unexpected Postnatal Collapse of Newborn Infants: A Review of Cases, Definitions, Risks, and Preventive Measures

Herlenius E; Kuhn P
Article: CURRENT PROTOCOLS IN STEM CELL BIOLOGY. 2012;Chapter 2:Unit-2D.13

Functional stem cell integration assessed by organotypic slice cultures.

Herlenius E; Thonabulsombat C; Forsberg D; Jäderstad J; Jäderstad LM; Björk L; Olivius P
Article: PEDIATRIC RESEARCH. 2012;72(5):460-467

mPGES-1 and prostaglandin E₂: vital role in inflammation, hypoxic response, and survival

Siljehav V; Hofstetter AO; Jakobsson P-J; Herlenius E
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(3):448-454

Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model

Ambrosi A; Dzikaite V; Park J; Strandberg L; Kuchroo VK; Herlenius E; Wahren-Herlenius M
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2012;307(3):275-282

Survival Without Disability to Age 5 Years After Neonatal Caffeine Therapy for Apnea of Prematurity

Schmidt B; Anderson PJ; Doyle LW; Dewey D; Grunau RE; Asztalos EV; Davis PG; Tin W; Moddemann D; Solimano A; Ohlsson A; Barrington KJ; Roberts RS
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2012;90(1):152-160

PRRT2 Mutations Cause Benign Familial Infantile Epilepsy and Infantile Convulsions with Choreoathetosis Syndrome

Heron SE; Grinton BE; Kivity S; Afawi Z; Zuberi SM; Hughes JN; Pridmore C; Hodgson BL; Iona X; Sadleir LG; Pelekanos J; Herlenius E; Goldberg-Stern H; Bassan H; Haan E; Korczyn AD; Gardner AE; Corbett MA; Gecz J; Thomas PQ; Mulley JC; Berkovic SF; Scheffer IE; Dibbens LM
Article: JOURNAL OF PEDIATRICS. 2011;159(4):546-550

Impact of Delivery Room Resuscitation on Outcomes up to 18 Months in Very Low Birth Weight Infants

DeMauro SB; Roberts RS; Davis P; Alvaro R; Bairam A; Schmidt B
Article: PEDIATRICS. 2011;127(1):E146-E155

Economic Evaluation of Caffeine for Apnea of Prematurity

Dukhovny D; Lorch SA; Schmidt B; Doyle LW; Kok JH; Roberts RS; Kamholz KL; Wang N; Mao W; Zupancic JAF
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(1):70-81

Dynamic changes in connexin expression following engraftment of neural stem cells to striatal tissue

Jaderstad J; Jaderstad LM; Herlenius E
Article: NEUROREPORT. 2010;21(17):1126-1132

Hypoxic preconditioning increases gap-junctional graft and host communication

Jaderstad J; Brismar H; Herlenius E
Article: REGENERATIVE MEDICINE. 2010;5(6):901-917

Graft and host interactions following transplantation of neural stem cells to organotypic striatal cultures

Jaderstad LM; Jaderstad J; Herlenius E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(11):5184-5189

Communication via gap junctions underlies early functional and beneficial interactions between grafted neural stem cells and the host

Jaderstad J; Jaderstad LM; Li J; Chintawar S; Salto C; Pandolfo M; Ourednik V; Teng YD; Sidman RL; Arenas E; Snyder EY; Herlenius E
Article: JOURNAL OF PEDIATRICS. 2010;156(3):382-U73

Caffeine for Apnea of Prematurity Trial: Benefits May Vary in Subgroups

Davis PG; Schmidt B; Roberts RS; Doyle LW; Asztalos E; Haslam R; Sinha S; Tin W
Article: ACTA PAEDIATRICA. 2008;97(3):285-292

Cardiorespiratory development in extremely preterm infants: vulnerability to infection and persistence of events beyond term-equivalent age

Hofstetter AO; Legnevall L; Herlenius E; Katz-Salamon M
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2007;357(19):1893-1902

Long-term effects of caffeine therapy for apnea of prematurity

Schmidt B; Roberts RS; Davis P; Doyle LW; Barrington KJ; Ohlsson A; Solimano A; Tin W
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(23):9894-9899

The induced prostaglandin E₂ pathway is a key regulator of the respiratory response to infection and hypoxia in neonates

Hofstetter AO; Saha S; Siljehav V; Jakobsson P-J; Herlenius E
Article: EPILEPSIA. 2007;48(6):1138-1142

SCN2A mutations and benign familial neonatal-infantile seizures:: The phenotypic spectrum

Herlenius E; Heron SE; Grinton BE; Keay D; Scheffer IE; Mulley JC; Berkovic SF
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2006;354(20):2112-2121

Caffeine therapy for apnea of prematurity

Schmidt B; Roberts RS; Davis P; Doyle LW; Barrington KJ; Ohlsson A; Solimano A; Tin W
Article: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2005;146(2-3):135-146

Interleukin-1β depresses hypoxic gasping and autoresuscitation in neonatal DBA/11acJ mice

Hofstetter AO; Herlenius E
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(1):11-17

Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block

Salomonsson S; Sonesson SE; Ottosson L; Muhallab S; Olsson T; Sunnerhagen M; Kuchroo VK; Thorén P; Herlenius E; Wahren-Herlenius M
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2004;556(1):43-59

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice

Nsegbe E; Wallen-Mackenzie Å; Dauger S; Roux JC; Shvarev Y; Lagercrantz H; Perlmann T; Herlenius E
Article: PEDIATRIC RESEARCH. 2003;54(3):326-331

IL-1β depresses respiration and anoxic survival via a prostaglandin-dependent pathway in neonatal rats

Olsson A; Kayhan G; Lagercrantz H; Herlenius E
Article: PEDIATRIC RESEARCH. 2002;51(1):4-12

Perinatal respiratory control and its modulation by adenosine and caffeine in the rat

Herlenius E; Ådén U; Tang LQ; Lagercrantz H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(16):9407-9412

Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A₁ receptor

Johansson B; Halldner L; Dunwiddie TV; Masino SA; Poelchen W; Giménez-Llort L; Escorihuela RM; Fernández-Teruel A; Wiesenfeld-Hallin Z; Xu XJ; Hårdemark A; Betsholtz C; Herlenius E; Fredholm BB
Article: BRAIN RESEARCH. 2000;884(1-2):201-205

Effects of neuroactive substances on the morphine-induced respiratory depression; an in vitro study

Takita K; Herlenius E; Yamamoto Y; Lindahl SGE
Article: PEDIATRIC RESEARCH. 2000;48(2):177-183

Maternal caffeine intake has minor effects on adenosine receptor ontogeny in the rat brain

Ådén U; Herlenius E; Tang LQ; Fredholm BB
Article: JOURNAL OF PHYSIOLOGY-LONDON. 1999;518(1):159-172

Adenosinergic modulation of respiratory neurones in the neonatal rat brainstem in vitro

Herlenius E; Lagercrantz H
Journal article: ANESTHESIOLOGY. 1998;89(Supplement):1358a

THE INTERACTION BETWEEN MORPHINE AND SOME NEUROACTIVE SUBSTANCES IN THE MEDULLARY RESPIRATION CENTER

Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
Journal article: PEDIATRIC RESEARCH. 1998;44(3):456

INFECTION AND INTERLEUKIN-1β VIA PROSTAGLANDIN E2 DEPRESSES RESPIRATION I: AN IN VITRO STUDY

Herlenius E; Lagercrantz H
Journal article: PEDIATRIC RESEARCH. 1998;44(3):456

INFECTION AND INTERLEUKIN-1β VIA PROSTAGLANDIN E2 DEPRESSES RESPIRATION II: AN IN VIVO STUDY

Herlenius E; Kayhan G; Lagercrantz H
Article: BRAIN RESEARCH. 1998;800(2):308-311

Age- and temperature-dependent effects of opioids on medulla oblongata respiratory activity: an in vitro study in newborn rat

Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
Journal article: ANESTHESIA AND ANALGESIA. 1998;86(2S):513s.-513S

THE INTERACTION BETWEEN MORPHINE AND ACETYLCHOLINE IN THE MEDULLARY RESPIRATION-RELATED STRUCTURES

Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
Article: BRAIN RESEARCH. 1997;778(1):233-241

Actions of opioids on respiratory activity via activation of brainstem μ-, δ- and κ-receptors;: an in vitro study

Takita K; Herlenius EAP; Lindahl SGE; Yamamoto Y
Article: PEDIATRIC RESEARCH. 1997;42(1):46-53

Adenosine modulates inspiratory neurons and the respiratory pattern in the brainstem of neonatal rats

Herlenius E; Lagercrantz H; Yamamoto Y
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Alla övriga publikationer

Preprint: RESEARCH SQUARE. 2024

Review and Inquiries on Ethics, Policies and Regulations of a Global Patient co-Owned Cloud (GPOC)

Lidströmer N; Davids J; ElSharkawy M; Ashrafian H; Herlenius E
Preprint: RESEARCH SQUARE. 2024

Technical Sandbox for a Global Patient co-Owned Cloud (GPOC)

Davids J; ElSharkawy M; Ashrafian H; Herlenius E; Lidströmer N
Preprint: RESEARCH SQUARE PLATFORM LLC. 2024

Technical Sandbox for a Global Patient co-Owned Cloud (GPOC)

Davids J; ElSharkawy M; Ashrafian H; Herlenius E; Lidströmer N
Preprint: RESEARCH SQUARE. 2024

Review of the Ethics, Policies and Regulations of a Global Patient co-Owned Cloud (GPOC)

Lidströmer N; Davids J; ElSharkawy M; Ashrafian H; Herlenius E
Preprint: RESEARCH SQUARE. 2024

A Summit on a Global Patient co-Owned Cloud (GPOC)

Lidströmer N; Davids J; ElSharkawy M; Herlenius E; Ashrafian H
Book chapter: MACHINE LEARNING APPLICATIONS IN MEDICINE AND BIOLOGY. 2024;p. 115-149

Deep Recurrent Architectures for Neonatal Sepsis Detection from Vital Signs Data

Honoré A; Siren H; Vinuesa R; Chatterjee S; Herlenius E
Review: JOURNAL OF PHYSIOLOGY-LONDON. 2023;601(21):4667-4689

Does fetal growth restriction induce neuropathology within the developing brainstem?

Ahmadzadeh E; Polglase GR; Stojanovska V; Herlenius E; Walker DW; Miller SL; Allison BJ
Preprint: RESEARCH SQUARE. 2023

Necessity of a Global Patient co-Owned Cloud (GPOC)

Lidströmer N; Davids J; ElSharkawy M; Herlenius E; Ashrafian H
Preprint: RESEARCH SQUARE. 2023

Systematic Review and Meta-Analysis for a Global Patient co-Owned Cloud (GPOC)

Lidströmer N; Davids J; ElSharkawy M; ElSharkawy M; Herlenius E; Ashrafian H
Conference publication: 2022;00:1-6

An LSTM-based Recurrent Neural Network for Neonatal Sepsis Detection in Preterm Infants

Honoré A; Siren H; Vinuesa R; Chatterjee S; Herlenius E
Review: ISCIENCE. 2022;25(5):104295

The effect of the delta SARS-CoV-2 variant on maternal infection and pregnancy

Samara A; Khalil A; O'Brien P; Herlenius E
Preprint: INSTITUTE OF ELECTRICAL AND ELECTRONICS ENGINEERS (IEEE). 2022

Classification and feature extraction for neonatal sepsis detection

Honoré A; Forsberg D; jost K; Adolphson K; Stålhammar A; Herlenius E; Chatterjee S
Preprint: INSTITUTE OF ELECTRICAL AND ELECTRONICS ENGINEERS (IEEE). 2022

Classification and feature extraction for neonatal sepsis detection

Honoré A; Forsberg D; jost K; Adolphson K; Stålhammar A; Herlenius E; Chatterjee S
Editorial comment: CELL REPORTS MEDICINE. 2022;3(1):100490

Potential role of neurofilament in COVID-19 and preeclampsia Comment

Samara A; Herlenius E; Brien PO; Khalil A
Book chapter: ARTIFICIAL INTELLIGENCE IN MEDICINE. 2022;p. 1047-1056

AIM in Neonatal and Pediatric Intensive Care

Forsberg D; Honoré A; Jost K; Persad E; Coste K; Chatterjee S; Rautiainen S; Herlenius E
Book chapter: ARTIFICIAL INTELLIGENCE IN COVID-19. 2022;p. 257-277

AI and Dynamic Prediction of Deterioration in Covid-19

Danker C; Murzabekov M; Forsberg D; Lidströmer N; Honoré A; Rautiainen S; Herlenius E
Review: ACTA PAEDIATRICA. 2021;110(12):3201-3226

Neonatal sepsis prediction through clinical decision support algorithms: A systematic review

Persad E; Jost K; Honore A; Forsberg D; Coste K; Olsson H; Rautiainen S; Herlenius E
Editorial comment: ACTA PAEDIATRICA. 2021;110(9):2578-2580

Persistent symptoms in Swedish children after hospitalisation due to COVID-19

Sterky E; Olsson-Akefeldt S; Hertting O; Herlenius E; Alfven T; Ryd Rinder M; Rhedin S; Hildenwall H
Conference publication: FASEB JOURNAL. 2021;35

Immune Modulator Prostaglandin E2 exerts Biphasic Dose Response on the Pre-Botzinger Complex Respiratory Related Rhythm

Reising J; Phillips W; Herlenius E
Conference publication: PEDIATRIC RESEARCH. 2021;90(SUPPL 1):22

Body weight measurements support machine-learning algorithms in neonatal sepsis prediction

Stalhammar AM; Adolphson K; Honore A; Forsberg D; Herlenius E; Jost K
Conference publication: PEDIATRIC RESEARCH. 2021;90(SUPPL 1):22

Predicting acute adverse events in neonates using automated vital sign pattern analysis

Adolphson K; Honore A; Forsberg D; Stalhammar AM; Jost K; Herlenius E
Conference publication: PEDIATRIC RESEARCH. 2021;90(SUPPL 1):13-14

Medications and clinical decision support systems; how caffeine influences heart rate characteristics in preterm infants

Clareus A; Honore A; Koch G; Herlenius E; Jost K
Book chapter: ARTIFICIAL INTELLIGENCE IN MEDICINE. 2021;p. 1-10

AIM in Neonatal and Paediatric Intensive Care

Forsberg D; Honoré A; Jost K; Persad E; Coste K; Chatterjee S; Rautiainen S; Herlenius E
Letter: ACTA PAEDIATRICA. 2020;109(10):2152-2154

Paediatric COVID-19 admissions in a region with open schools during the two first months of the pandemic

Hildenwall H; Luthander J; Rhedin S; Hertting O; Olsson-Akefeldt S; Erik M; Alfven T; Herlenius E; Ryd Rinder M
Conference publication: 2020;00:1130-1134

Hidden Markov Models for Sepsis Detection in Preterm Infants

Honoré A; Liu D; Forsberg D; Coste K; Herlenius E; Chatterjee S; Skoglund M
Preprint: BIORXIV. 2019

Presynaptic dysfunction inCASK-related neurodevelopmental disorders

Becker M; Mastropasqua F; Reising JP; Maier S; Ho M-L; Rabkina I; Li D; Neufeld J; Ballenberger L; Myers L; Moritz V; Kele M; Wincent J; Willfors C; Sitnikov R; Herlenius E; Anderlid B-M; Falk A; Bölte S; Tammimies K
Preprint: ARXIV. 2019

Hidden Markov Models for sepsis detection in preterm infants

Honore A; Liu D; Forsberg D; Coste K; Herlenius E; Chatterjee S; Skoglund M
Published conference paper: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2019;265:3-8

Astrocyte networks modulate respiration - sniffing glue

Forsberg D; Herlenius E
Letter: JAMA PEDIATRICS. 2019;173(5):487-489

Self-reported Quality of Life at Middle School Age in Survivors of Very Preterm Birth: Results From the Caffeine for Apnea of Prematurity Trial

Schmidt B; Anderson PJ; Asztalos EV; Doyle L; Grunau RE; Moddemann D; Roberts RS
Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1423

Resolving effects of CASK mutations in children with neurodevelopmental disorders

Becker M; Mastropasqua F; Reising JP; Rabkina I; Ballenberger L; Kele M; Willfors C; Herlenius E; Bolte S; Anderlid BM; Falk A; Tammimies K
Preprint: ARXIV. 2017

Large Neural Network Based Detection of Apnea, Bradycardia and Desaturation Events

Honoré A; Siljehav V; Chatterjee S; Herlenius E
Conference publication: CANCER RESEARCH. 2017;77:5832

Rho-associated kinase is a therapeutic target in neuroblastoma

Dyberg CH; Fransson S; Andonova T; Sveinbjornsson B; Lannerholm-Palm J; Forsberg D; Herlenius E; Martinsson T; Kogner P; Johnsen JI; Wickstrom M
Preprint: BIORXIV. 2017

Astrocytes release prostaglandin E2 to modify respiratory network activity

Forsberg D; Ringstedt T; Herlenius E
Review: CANCER CAUSES & CONTROL. 2017;28(6):599-624

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis

Karalexi MA; Dessypris N; Skalkidou A; Biniaris-Georgallis S-I; Kalogirou EI; Thomopoulos TP; Herlenius E; Spector LG; Loutradis D; Chrousos GP; Petridou ET
Editorial comment: ACTA PAEDIATRICA. 2017;106(2):191-193

Unexpected, unexplained and life-threatening events in infants are age-dependent descriptive syndromes with different risk and management

Herlenius E
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67

Auxilin Is a Novel Susceptibility Gene for Congenital Heart Block Modulating Cardiac Function

Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Dzikaite-Ottosson V; Ding B; Strandberg L; Biavati L; Ramskold D; Forsberg D; Bergin L; Ruhrmann S; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
Meeting abstract: PEDIATRIC RESEARCH. 2011;70:24

THE CAFFEINE FOR APNEA OF PREMATURITY (CAP) TRIAL: PRELIMINARY OUTCOMES AT 5 YEARS

Schmidt B; Anderson P; Doyle L; Dewey D; Grunau R; Asztalos E; Davis P; Tin W; Moddemann D; Solimano A; Ohlsson A; Barrington K; Roberts R
Review: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY. 2011;178(3):449-457

An inflammatory pathway to apnea and autonomic dysregulation

Herlenius E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):349-350

Transfer of Ro52-p200 Monoclonals, but not Other Ro52-Specificities, Induce Congenital Heart Block (CHB) in a Rat Model

Dzikaite V; Ambrosi A; Park J; Ottosson L; Sonesson S-E; Kuchroo VK; Herlenius E; Wahren-Herlenius M
Published conference paper: EUROPEAN JOURNAL OF NEUROSCIENCE. 2010;31(12):2142-2155

Premature expression of KCC2 in embryonic mice perturbs neural development by an ion transport-independent mechanism

Horn Z; Ringstedt T; Blaesse P; Kaila K; Herlenius E
Book chapter: THE NEWBORN BRAIN. 2010;p. 99-120

Neurotransmitters and neuromodulators

Herlenius E; Lagercrantz H
Book chapter: THE NEWBORN BRAIN. 2010;p. 71-84

The neonatal synaptic big bang

Bourgeois J-P
Conference publication: ACTA PAEDIATRICA. 2010;99:19

INFECTIOUS DISEASES AND SIDS: AN INFLAMMATORY PATHWAY TO APNEA AND AUTONOMIC DYSREGULATION

Herlenius E
Conference publication: CELL TRANSPLANTATION. 2010;19(3):344

Communication Via Gap Junctions Underlies Early Functional and Beneficial Interactions Between Grafted Neural Stem Cells and the Host

Jaderstad J; Jaderstad LM; Li J; Chintawar S; Salto C; Pandolfo M; Ourednik V; Teng YD; Sidman RL; Arenas E; Snyder EY; Herlenius E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):274

Ro52 Autoantibodies Specific for Amino Acid 200-239 Mediate Calcium Dysregulation in Cardiomyocytes

Herlenius E; Park J; Ambrosi A; Dzikate V; Strandberg L; Kuchroo V; Wahren-Herlenius M
Conference publication: EPILEPSIA. 2007;48:127

Benign familial neonatal-infantile seizures: The mutational and phenotypic spectrum

Heron S; Grinton B; Herlenius E; Keay D; Kron K; Mulley J; Scheffer I; Berkovic S
Meeting abstract: EXPERIMENTAL NEUROLOGY. 2006;198(2):572

Communication via gap junctions underlies early functional interactions between grafted neural stem cells and the host

Jäderstad J; Danielsson LM; Ourednik V; Snyder EY; Herlenius E
Conference publication: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2006;79(1-2):156

MPGES-1 derived PGE2 regulates fever and mediates IL-1beta induced respiratory depression in DBA/11acj mice through central mechanisms

Saha S; Engström L; Mackerlova L; Hofstetter AO; Hebert H; Herlenius E; Blomqvist A; Jakobsson PJ
Review: EXPERIMENTAL NEUROLOGY. 2004;190:S8-21

Development of neurotransmitter systems during critical periods

Herlenius E; Lagercrantz H
Meeting abstract: PEDIATRIC RESEARCH. 2004;56(3):482

Reduced expression of microsomal prostaglandin synthase 1 attenuates ventilatory effects of interleukin-1A in neonatal DBA/1LacJ mice

Hofstetter AO; Saha S; Lagercrantz H; Jakobsson PJ; Herlenius E
Conference publication: PEDIATRIC RESEARCH. 2004;55(4):511A

Interieukin-1β depresses respiration and anoxic survival in newborn mice

Hofstetter AO; Saba S; Lagercrantz H; Jakobsson PJ; Herlenius E
Published conference paper: DRUG DEVELOPMENT RESEARCH. 2003;58(4):350-353

Consequences of eliminating adenosine A₁ receptors in mice

Fredholm BB; Halldner L; Johansson C; Schulte G; Lövdahl C; Thorén P; Dunwiddie TV; Masino SA; Poelchen W; Diao LH; Illes P; Zahniser NR; Valen G; Tokuno S; Sommerschild H; Giménez-Llort L; Fernández-Teruel A; Escorihuela RM; Wiesenfeld-Hallin Z; Xu XJ; Hårdemark A; Herlenius E; Pekny S; Gebré-Medhin S; Brown R; Ollerstam A; Persson AEG; Skott O; Johansson B
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):S64

Ro52 monoclonal antibodies bind the cell surface of cardiomyocytes

Salomonsson S; Ottosson L; RAats J; Herlenius E; Wahren-Herlenius M
Conference publication: PEDIATRIC RESEARCH. 2003;54(4):594

Integration of exogenous stem cells into striatal organotypic cultures

Jäderstad J; Ourednik V; Snyder EY; Herlenius E
Conference publication: EXPERIMENTAL NEUROLOGY. 2002;175(2):418

Tracing of multisynaptic fiber tracts originating from grafted neural stem cells - A study using plant lectins.

Ourednik V; Ourednik J; Herlenius E; Zou Z; Snyder EY
Review: EARLY HUMAN DEVELOPMENT. 2001;65(1):21-37

Neurotransmitters and neuromodulators during early human development

Herlenius E; Lagercrantz H
Conference publication: JOURNAL OF PHYSIOLOGY-LONDON. 2001;533:10S

Respiratory rhythm generation in the perinatal period and its modulation by GABA and adenosine

Herlenius E
Conference publication: PEDIATRIC RESEARCH. 2000;47(4):70A

Fetal and neonatal respiratory activity and its modulation by adenosine and caffeine

Herlenius E; Aden U; Tang LO; Lagercrantz H
Thesis / dissertation: 1998

Respiratory activity in medulla oblongata and its modulation by adenosine and opioids

Herlenius, Eric
Conference publication: ANESTHESIOLOGY. 1998;89(3A):U1037

The interaction between morphine and some neuroactive substances in the medullary respiration center:: An in vitro study in the newborn rat.

Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
Conference publication: ANESTHESIA AND ANALGESIA. 1998;86(2S)

The interaction between morphine and acetylcholine in the medullary respiration-related structures:: An in vitro study in the newborn rat.

Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
Meeting abstract: ANESTHESIOLOGY. 1997;87(3):A1074

Mu-1 opioid receptor in the medulla oblongata is involved in the opioid-induced respiratory depression: An in vitro study in the newborn rat.

Takita K; Herlenius E; Lindahl SGE; Yamamoto Y
Preprint: SSRN ELECTRONIC JOURNAL.

Astrocytic Calcium Signaling Toolkit (astroCAST): Efficient Analysis of Dynamic Astrocytic Calcium Events

Reising J; Sanchez ACG; Samara A; Herlenius E
Visa fler

Forskningsbidrag

Genes(is) of Inspiration - Screen, detect and protect against inflammation induced life-threatening events.

Swedish Research Council

1 January 2024 - 31 December 2027
Probiotic supplementation in extremely preterm infants in Scandinavia: A double-blinded randomized controlled multicenter trial to reduce the risk of necrotizing enterocolitis and mortality

Swedish Research Council

1 January 2023 - 31 December 2026
INSPIRATION AND LIFE-THREATENING EVENTS AFTER BIRTH – Pathophysiological mechanisms

Swedish Research Council

1 January 2020 - 31 December 2023
APNEA and INSPIRATIONSCREEN, DETECT AND PROTECT AGAINST INFLAMMATION INDUCED LIFE-THREATENING EVENTS

Swedish Heart-Lung Foundation

1 January 2019 - 31 December 2021
NEWS - Newborn Early Warning Signs

Swiss National Science Foundation

1 June 2017 - 31 July 2017
INSPIRATION AND LIFE-THREATENING EVENTS AFTER BIRTH – Pathophysiological mechanisms

Swedish Research Council

1 January 2017 - 31 December 2019
Novel methods to SCREEN, DETECT and PROTECT against life threatening respiratory dysfunction

VINNOVA

6 December 2010 - 30 November 2014
ACTIVITY DEPENDENT DEVELOPMENT OF AUTONOMIC CONTROL APNEA INFLAMMATION and INSPIRATION

Swedish Research Council

1 January 2010 - 31 December 2012
Activity dependent development of autonomic control

Swedish Research Council

1 January 2009 - 31 December 2014
Activity dependent development of autonomic control

Swedish Research Council

1 January 2009 - 31 December 2014
Activity dependent development of autonomic control

Swedish Research Council

1 January 2009 - 31 December 2014

Anställningar

Professor/Överläkare, Kvinnors och barns hälsa, Karolinska Institutet, 2013-

Examina och utbildning

Docent, Experimentell pediatrik, Karolinska institutet, 2008
MEDICINE DOKTORSEXAMEN, Institutionen för kvinnors och barns hälsa, Karolinska Institutet, 1998
Läkarexamen, Karolinska Institutet, 1994

Om mig

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Anställningar

Examina och utbildning

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