Varför orsakar hantavirus sjukdom i människa? – Jonas Klingström forskargrupp

Article: JOURNAL OF IMMUNOLOGY. 2020;205(9):2437-2446

Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients.

Varnaitė R; García M; Glans H; Maleki KT; Sandberg JT; Tynell J; Christ W; Lagerqvist N; Asgeirsson H; Ljunggren H-G; Ahlén G; Frelin L; Sällberg M; Blom K; Klingström J; Gredmark-Russ S

Article: PLOS PATHOGENS. 2020;16(2):e1008297

Hantavirus inhibits apoptosis by preventing mitochondrial membrane potential loss through up-regulation of the pro-survival factor BCL-2.

Solà-Riera C; García M; Ljunggren H-G; Klingström J

Article: JOURNAL OF VIROLOGY. 2020;94(3):e01168-e01119

Puumala and Andes Orthohantaviruses Cause Transient Protein Kinase R-Dependent Formation of Stress Granules.

Christ W; Tynell J; Klingström J

Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(12):e1224

Innate lymphoid cell composition associates with COVID-19 disease severity.

García M; Kokkinou E; Carrasco García A; Parrot T; Palma Medina LM; Maleki KT; Christ W; Varnaitė R; Filipovic I; Ljunggren H-G; Björkström NK; Folkesson E; Rooyackers O; Eriksson LI; Sönnerborg A; Aleman S; Strålin K; Gredmark-Russ S; Klingström J; Mjösberg J; Karolinska KI/K COVID‐19 Study Group

Article: CELL REPORTS. 2019;28(8):2124-2139.e6

Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5.

Solà-Riera C; Gupta S; Maleki KT; González-Rodriguez P; Saidi D; Zimmer CL; Vangeti S; Rivino L; Leo Y-S; Lye DC; MacAry PA; Ahlm C; Smed-Sörensen A; Joseph B; Björkström NK; Ljunggren H-G; Klingström J

Article: JOURNAL OF INFECTIOUS DISEASES. 2019;219(11):1832-1840

Serum Markers Associated with Severity and Outcome of Hantavirus Pulmonary Syndrome.

Maleki KT; García M; Iglesias A; Alonso D; Ciancaglini M; Hammar U; Ljunggren H-G; Schierloh P; Martínez VP; Klingström J

Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(5):510-523

Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes.

Klingström J; Smed-Sörensen A; Maleki KT; Solà-Riera C; Ahlm C; Björkström NK; Ljunggren HG

Article: SCIENTIFIC REPORTS. 2019;9(1):834

Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells.

Solà-Riera C; Gupta S; Ljunggren H-G; Klingström J

Article: CLINICAL INFECTIOUS DISEASES. 2018;66(2):268-273

Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study.

Connolly-Andersen A-M; Whitaker H; Klingström J; Ahlm C

Article: PLOS PATHOGENS. 2017;13(6):e1006462

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways.

Scholz S; Baharom F; Rankin G; Maleki KT; Gupta S; Vangeti S; Pourazar J; Discacciati A; Höijer J; Bottai M; Björkström NK; Rasmuson J; Evander M; Blomberg A; Ljunggren H-G; Klingström J; Ahlm C; Smed-Sörensen A

Article: PLOS PATHOGENS. 2014;10(11):e1004521

NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Rα expression.

Braun M; Björkström NK; Gupta S; Sundström K; Ahlm C; Klingström J; Ljunggren H-G

Article: CLINICAL INFECTIOUS DISEASES. 2014;59(8):1130-1132

Increased risk for lymphoma following hemorrhagic fever with renal syndrome.

Klingström J; Granath F; Ekbom A; Björkström NK; Ljunggren H-G

Article: CIRCULATION. 2014;129(12):1295-1302

Increased risk of acute myocardial infarction and stroke during hemorrhagic fever with renal syndrome: a self-controlled case series study.

Connolly-Andersen A-M; Hammargren E; Whitaker H; Eliasson M; Holmgren L; Klingström J; Ahlm C

Article: EMERGING INFECTIOUS DISEASES. 2013;19(1):126-128

Puumala virus infections associated with cardiovascular causes of death.

Connolly-Andersen A-M; Ahlm K; Ahlm C; Klingström J