Team Michael Sundström

Research focus
We focus on exploring novel target biology for future drug development, in particular within chronic inflammatory diseases, neurodegenerative diseases and liver fibrosis.

Introduction

We are part of the Structural Genomics Consortium (SGC www.thesgc.org), a public-private partnership that supports the discovery of new medicines through open access research. Besides Karolinska Institutet, the SGC comprises research teams at the Goethe University in Frankfurt, the University of Toronto and the University of North Carolina as well as affiliated collaborators at the University of Oxford, the State University of Campinas, Brazil and the Neuro at McGill University. The SGC Karolinska lab focuses on two scientific areas - cell-based assays on patient-derived cells and generating recombinant antibodies to selected target proteins. We have a particular interest in studying chronic inflammation as well as neurodegenerative diseases and liver fibrosis.

Major research focus

The SGC Karolinska laboratory has research efforts in biotechnology, protein production, phage display, antibody validation, cell culture, patient-derived cell-based assays and mass spectrometry. The SGC encourages collaborations with laboratories across the globe, focused on proteins of medical relevance and their modulators of functions, such as small molecule inhibitors and antibodies.

Collaborations

Maja Jagodic https://ki.se/en/cns/maja-jagodics-research-group
Pekka Katajisto https://www.katajisto-lab.com/
Volker Lauschke https://ki.se/en/fyfa/lauschke-lab-personalized-medicine-and-drug-development
Helena Persson Lotsholm https://www.scilifelab.se/facilities/human-antibody-therapeutics
Anna-Lena Gustavsson https://www.scilifelab.se/facilities/cbcs
Evert Homan and Ulrika Warpman Berglund http://helleday.org/

Team members

Louise Berg

Kristina Edfeldt

Susanne Gräslund

Andrea Introini

Rodrigo Lozano

Mohammad Ali Okhovat

Charlotta Preger

Ming-Mei Shang

Michael Sundström

Edvard Wigren

Sonia Youhanna

Recent key publications

Generation and validation of recombinant antibodies to study human aminoacyl-tRNA synthetases.
Preger C, Wigren E, Ossipova E, Marks C, Lengqvist J, Hofström C, et al
J Biol Chem 2020 Oct;295(41):13981-13993

Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E2 Production.
Bergqvist F, Sundström Y, Shang MM, Gunnarsson I, Lundberg IE, Sundström M, et al
Front Pharmacol 2020 ;11():613

Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay.
Sundström Y, Shang MM, Panda SK, Grönwall C, Wermeling F, Gunnarsson I, et al
Transl Res 2020 Sep;():

A genetics-led approach defines the drug target landscape of 30 immune-related traits.
Fang H, , De Wolf H, Knezevic B, Burnham KL, Osgood J, et al
Nat Genet 2019 07;51(7):1082-1091

Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, et al
Front Immunol 2019 ;10():1029

Patients with anti-Jo1 antibodies display a characteristic IgG Fc-glycan profile which is further enhanced in anti-Jo1 autoantibodies.
Fernandes-Cerqueira C, Renard N, Notarnicola A, Wigren E, Gräslund S, Zubarev RA, et al
Sci Rep 2018 12;8(1):17958

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.
Favalli N, Biendl S, Hartmann M, Piazzi J, Sladojevich F, Gräslund S, et al
ChemMedChem 2018 07;13(13):1303-1307

In Vivo Biotinylation of Antigens in E. coli.
Gräslund S, Savitsky P, Müller-Knapp S
Methods Mol Biol 2017 ;1586():337-344

Antibody Validation by Immunoprecipitation Followed by Mass Spectrometry Analysis.
Persson H, Preger C, Marcon E, Lengqvist J, Gräslund S
Methods Mol Biol 2017 ;1575():175-187