Michael Sundström

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2023;63(21):6696-6705
PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands
Simon IA; Homan EJ; Wijtmans M; Sundstrom M; Leurs R; De Esch IJP; Zarzycka BA
Article: SCIENCE ADVANCES. 2022;8(41):eabm1847
Cellular shape reinforces niche to stem cell signaling in the small intestine
Pentinmikko N; Lozano R; Scharaw S; Andersson S; Englund JI; Castillo-Azofeifa D; Gallagher A; Broberg M; Song K-Y; Carvajal AS; Speidel AT; Sundstrom M; Allbritton N; Stevens MM; Klein OD; Teixeira A; Katajisto P
Article: RSC MEDICINAL CHEMISTRY. 2022;13(1):13-21
Target 2035-update on the quest for a probe for every protein
Mueller S; Ackloo S; Al Chawaf A; Al-Lazikani B; Antolin A; Baell JB; Beck H; Beedie S; Betz UAK; Bezerra GA; Brennan PE; Brown D; Brown PJ; Bullock AN; Carter AJ; Chaikuad A; Chaineau M; Ciulli A; Collins I; Dreher J; Drewry D; Edfeldt K; Edwards AM; Egner U; Frye SV; Fuchs SM; Hall MD; Hartung IV; Hillisch A; Hitchcock SH; Homan E; Kannan N; Kiefer JR; Knapp S; Kostic M; Kubicek S; Leach AR; Lindemann S; Marsden BD; Matsui H; Meier JL; Merk D; Michel M; Morgan MR; Mueller-Fahrnow A; Owen DR; Perry BG; Rosenberg SH; Saikatendu KS; Schapira M; Scholten C; Sharma S; Simeonov A; Sundstrom M; Superti-Furga G; Todd MH; Tredup C; Vedadi M; von Delft F; Willson TM; Winter GE; Workman P; Arrowsmith CH
Article: TRANSLATIONAL RESEARCH. 2021;229:69-82
Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay
Sundstrom Y; Shang M-M; Panda SK; Gronwall C; Wermeling F; Gunnarsson I; Lundberg IE; Sundstrom M; Jakobsson P-J; Berg L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(34):20753-20763
Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300
Williams LM; McCann FE; Cabrita MA; Layton T; Cribbs A; Knezevic B; Fang H; Knight J; Zhang M; Fischer R; Bonham S; Steenbeek LM; Yang N; Sood M; Bainbridge C; Warwick D; Harry L; Davidson D; Xie W; Sundstrom M; Feldmann M; Nanchahal J
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:613
Anti-Inflammatory Properties of Chemical Probes in Human Whole Blood: Focus on Prostaglandin E₂ Production
Bergqvist F; Sundstrom Y; Shang M-M; Gunnarsson I; Lundberg IE; Sundstrom M; Jakobsson P-J; Berg L
Article: NATURE GENETICS. 2019;51(7):1082-1091
A genetics-led approach defines the drug target landscape of 30 immune-related traits
Fang H; Beckmann G; Bountra C; Bowness P; Burgess-Brown N; Carpenter L; Chen L; Damerell D; Egner U; Fujii R; Howe T; Jakobsson P-J; Katopodis A; Knight JC; Marsden BD; De Martino J; Matthias G; McVean G; Mueller-Fahrnow A; Malarstig A; O'Callaghan CA; Ostermann N; Paez-cortez JR; Peeters PJ; Prinz F; Soulard P; Sundstrom M; Yabuki C; Vlach J; De Wolf H; Knezevic B; Burnham KL; Osgood J; Sanniti A; Lara AL; Kasela S; De Cesco S; Wegner JK; Handunnetthi L; McCann FE; Sekine T; Brennan PE; Sundstrom Y; Milani L; Berg L; Gohlmann HW; Fairfax BP
Article: MOLECULAR PHARMACEUTICS. 2016;13(5):1587-1598
Large-Scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities
Vernet E; Popa G; Pozdnyakova I; Rasmussen JE; Grohganz H; Giehm L; Jensen MH; Wang H; Plesner B; Nielsen HM; Jensen KJ; Berthelsen J; Sundstrom M; van de Weert M
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(Suppl 1):a67
A8.07 Characterising effects of epigenetic regulation in assays using peripheral blood mononuclear cells from patients with inflammatory diseases
Aftab O; Sundström Y; Bergqvist F; Kultima K; Gustafsson; Larsson R; Sundström M; Ossipova E; Lengqvist J; Jakobsson P; Rubin J; Berg L
Article: NATURE CHEMICAL BIOLOGY. 2015;11(8):536-541
The promise and peril of chemical probes
Arrowsmith CH; Audia JE; Austin C; Baell J; Bennett J; Blagg J; Bountra C; Brennan PE; Brown PJ; Bunnage ME; Buser-Doepner C; Campbell RM; Carter AJ; Cohen P; Copeland RA; Cravatt B; Dahlin JL; Dhanak D; Edwards AM; Frye SV; Gray N; Grimshaw CE; Hepworth D; Howe T; Huber KVM; Jin J; Knapp S; Kotz JD; Kruger RG; Lowe D; Mader MM; Marsden B; Mueller-Fahrnow A; Mueller S; O'Hagan RC; Overington JP; Owen DR; Rosenberg SH; Roth B; Ross R; Schapira M; Schreiber SL; Shoichet B; Sundstrom M; Superti-Furga G; Taunton J; Toledo-Sherman L; Walpole C; Walters MA; Willson TM; Workman P; Young RN; Zuercher WJ
Article: CURRENT OPINION IN PHARMACOLOGY. 2014;17:58-63
Recently targeted kinases and their inhibitors - the path to clinical trials
Knapp S; Sundstrom M
Journal article: FEBS JOURNAL. 2013;280(23):6010-6021
Heterologous expression and purification of an active human TRPV3 ion channel.
Kol S; Braun C; Thiel G; Doyle DA; Sundström M; Gourdon P; Nissen P
Journal article: MOLECULAR CELL. 2013;51(6):707-722
Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.
Francavilla C; Rigbolt KTG; Emdal KB; Carraro G; Vernet E; Bekker-Jensen DB; Streicher W; Wikström M; Sundström M; Bellusci S; Cavallaro U; Blagoev B; Olsen JV
Journal article: PROTEIN EXPRESSION AND PURIFICATION. 2011;77(1):104-111
Screening of genetic parameters for soluble protein expression in Escherichia coli.
Vernet E; Kotzsch A; Voldborg B; Sundström M
Article: PROTEIN SCIENCE. 2011;20(3):597-609
A secretory system for bacterial production of high-profile protein targets
Kotzsch A; Vernet E; Hammarstrom M; Berthelsen J; Weigelt J; Graslund S; Sundstrom M
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(17):6457-6462
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M; Willard FS; Kimple AJ; Turnbull AP; Ball LJ; Schoch GA; Gileadi C; Fedorov OY; Dowler EF; Higman VA; Hutsell SQ; Sundström M; Doyle DA; Siderovski DP
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(51):20523-20528
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Fedorov O; Marsden B; Pogacic V; Rellos P; Müller S; Bullock AN; Schwaller J; Sundström M; Knapp S
Journal article: JOURNAL OF STRUCTURAL AND FUNCTIONAL GENOMICS. 2007;8(2-3):107-119
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.
Gileadi O; Knapp S; Lee WH; Marsden BD; Müller S; Niesen FH; Kavanagh KL; Ball LJ; von Delft F; Doyle DA; Oppermann UCT; Sundström M
Journal article: NATURE. 2007;448(7149):87-91
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Ng SS; Kavanagh KL; McDonough MA; Butler D; Pilka ES; Lienard BMR; Bray JE; Savitsky P; Gileadi O; von Delft F; Rose NR; Offer J; Scheinost JC; Borowski T; Sundstrom M; Schofield CJ; Oppermann U
Journal article: DRUG DISCOVERY TODAY. 2007;12(9-10):365-372
Insights for the development of specific kinase inhibitors by targeted structural genomics.
Fedorov O; Sundström M; Marsden B; Knapp S
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(46):17237-17242
Structural basis for protein-protein interactions in the 14-3-3 protein family.
Yang X; Lee WH; Sobott F; Papagrigoriou E; Robinson CV; Grossmann JG; Sundström M; Doyle DA; Elkins JM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(43):15835-15840
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
Vedadi M; Niesen FH; Allali-Hassani A; Fedorov OY; Finerty PJJ; Wasney GA; Yeung R; Arrowsmith C; Ball LJ; Berglund H; Hui R; Marsden BD; Nordlund P; Sundstrom M; Weigelt J; Edwards AM
Journal article: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS OF CRYSTALLOGRAPHY. 2006;62(a1):s16
Structural genomics on human kinases at SGC Oxford
Debreczeni JÉ; Knapp S; von Delft F; Sundstrom M
Journal article: EXPERT OPINION ON DRUG DISCOVERY. 2006;1(2):123-136
High-throughput structural characterisation of therapeutic protein targets.
Marsden BD; Sundstrom M; Knapp S
Journal article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2006;64(1):60-67
Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.
Trosset J-Y; Dalvit C; Knapp S; Fasolini M; Veronesi M; Mantegani S; Gianellini LM; Catana C; Sundström M; Stouten PFW; Moll JK
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(20):7637-7642
Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.
Bullock AN; Debreczeni JE; Edwards AM; Sundström M; Knapp S
Journal article: TRENDS IN BIOCHEMICAL SCIENCES. 2006;31(2):76-78
Disseminating structural genomics data to the public: from a data dump to an animated story.
Abagyan R; Lee WH; Raush E; Budagyan L; Totrov M; Sundstrom M; Marsden BD
Journal article: JOURNAL OF BIOMOLECULAR NMR. 2000;18(1):65-68
Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water.
Dalvit C; Pevarello P; Tatò M; Veronesi M; Vulpetti A; Sundström M
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2000;143(1):71-76
Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation
Enberg B; Luthman H; Segnestam K; Ritzén EM; Sundström M; Norstedt G
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1994;269(42):26531-26538
MUTUALLY EXCLUSIVE BINDING OF PEPTIDE AND INVARIANT CHAIN TO MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II ANTIGENS
ERICSON ML; SUNDSTROM M; SANSOM DM; CHARRON DJ
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Editorial comment: RSC MEDICINAL CHEMISTRY. 2023;14(6):1002-1011
Target 2035-an update on private sector contributions
Ackloo S; Antolin AA; Bartolome JM; Beck H; Bullock A; Betz UAK; Boettcher J; Brown PJ; Chaturvedi M; Crisp A; Daniels D; Dreher J; Edfeldt K; Edwards AM; Egner U; Elkins J; Fischer C; Glendorf T; Goldberg S; Hartung IV; Hillisch A; Homan E; Knapp S; Koester M; Kraemer O; Llaveria J; Lessel U; Lindemann S; Linderoth L; Matsui H; Michel M; Montel F; Mueller-Fahrnow A; Mueller S; Owen DR; Saikatendu KS; Santhakumar V; Sanderson W; Scholten C; Schapira M; Sharma S; Shireman B; Sundstrom M; Todd MH; Tredup C; Venable J; Willson TM; Arrowsmith CH
Preprint: BIORXIV. 2020
Identifying novel B-cell targets for chronic inflammatory autoimmune disease by screening of chemical probes in a patient-derived cell assay
Sundström Y; Shang M-M; Panda SK; Grönwall C; Wermeling F; Gunnarsson I; Lundberg I; Sundström M; Jakobsson P-J; Berg L
Preprint: BIORXIV. 2019
Anti-inflammatory properties of chemical probes in human whole blood: focus on prostaglandin E2 production
Bergqvist F; Sundström Y; Shang M; Gunnarsson I; Lundberg I; Sundström M; Jakobsson P-J; Berg L
Book chapter: TARGET DISCOVERY AND VALIDATION: METHODS AND PRINCIPLES IN MEDICINAL CHEMISTRY. 2019;p. 1-24
Chemical Strategies for Evaluating New Drug Targets
Carter AJ; Seupel R; Brennan PE; Sundström M; Introini A; Mueller‐Fahrnow A
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;90(6)
Identifying novel B cell targets by screening of chemical probes in a patient-derived cell assay
Panda SK; Sundstrom Y; Shang M-M; Gronwall C; Wermeling F; Gunnarsson I; Lundberg I; Sundstrom M; Jakobsson P-J; Berg L
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49:1985-1986
Combined data driven computational tool and B cell maturation assay for new target identification in systemic lupus erythematosus
Shang M-M; Knezevic B; Fang H; Moller C; Panda SK; Sundstrom Y; Jakobsson P-J; Sundstrom M; Knight JC; Berg L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(Suppl 1):a28
02.48 Inhibition of in vitro b cell maturation and igg secretion by new chemical probes in assays using blood cells from patients with sle and iim
Sundström Y; Bergqvist F; Sundström M; Ossipova E; Lengqvist J; Gunnarsson I; Lundberg I; Jakobsson P-J; Berg L
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2016;45:44-45
Characterizing the effects of epigenetic regulation in assays using peripheral blood mononuclear cells from patients with inflammatory diseases
Berg L; Sundstrom Y; Aftab O; Bergqvist F; Kultima K; Gustafsson M; Larsson R; Sundstrom M; Ossipova E; Lengqvist J; Jakobsson P-J; Rubin J
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2016;34(4):S64
INHIBITION OF IN VITRO B CELL MATURATION BY NEW CHEMICAL PROBES IN ASSAYS USING BLOOD CELLS FROM PATIENTS WITH SLE AND IIM
Sundstrom Y; Chen T; Bergqvist F; Sundstrom M; Taunton J; Ossipova E; Lengqvist J; Gunnarsson I; Lundberg I; Jakobsson PJ; Berg L
Editorial comment: NATURE REVIEWS DRUG DISCOVERY. 2015;14(3):149-150
Preclinical target validation using patient-derived cells
Edwards AM; Arrowsmith CH; Bountra C; Bunnage ME; Feldmann M; Knight JC; Patel DD; Prinos P; Taylor MD; Sundstrom M
Letter: NATURE METHODS. 2008;5(10):854-855
A pilot project to generate affinity reagents to human proteins
Uhlen M; Graeslund S; Sundstroem M
Book chapter: ANNUAL REPORTS IN MEDICINAL CHEMISTRY VOLUME 40: DESIGN OF COVALENT-BASED INHIBITORS. 2005;p. 349-369
Structural Genomics and Drug Discovery
Edwards A; Berman J; Sundstrom M
Review: PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY. 1997;57:73-94
Stimulation of kinase cascades by growth hormone: A paradigm for cytokine signaling
Wood TJJ; Haldosen LA; Sliva D; Sundstrom M; Norstedt G

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