Svåra akuta bakteriella infektioner: sjukdomsmekanismer och individanpassad medicin – Anna Norrby-Teglund grupp

Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2021;65(11):e0065821-e00621

Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models.

Bergsten H; Palma Medina LM; Morgan M; Moll K; Skutlaberg DH; Skrede S; Wajima T; Svensson M; Norrby-Teglund A

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.

Lourda M; Dzidic M; Hertwig L; Bergsten H; Palma Medina LM; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki KT; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ; Karolinska KI/K COVID-19 Study Group

Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(14):149523

Discriminatory plasma biomarkers predict specific clinical phenotypes of necrotizing soft-tissue infections.

Palma Medina LM; Rath E; Jahagirdar S; Bruun T; Madsen MB; Strålin K; Unge C; Hansen MB; Arnell P; Nekludov M; Hyldegaard O; Lourda M; Santos VAMD; Saccenti E; Skrede S; Svensson M; Norrby-Teglund A

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.

Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Hed Myrberg I; Lourda M; Dzidic M; Akber M; Klingström J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Ginhoux F; Björkström NK; Henter J-I; Svensson M; Karolinska KI/K COVID-19 Study Group

Article: CLINICAL INFECTIOUS DISEASES. 2021;72(2):293-300

Risk Factors and Predictors of Mortality in Streptococcal Necrotizing Soft-tissue Infections: A Multicenter Prospective Study.

Bruun T; Rath E; Madsen MB; Oppegaard O; Nekludov M; Arnell P; Karlsson Y; Babbar A; Bergey F; Itzek A; Hyldegaard O; Norrby-Teglund A; Skrede S; INFECT Study Group

Editorial comment: CLINICAL INFECTIOUS DISEASES. 2020;71(7):1772-1775

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections.

Bergsten H; Madsen MB; Bergey F; Hyldegaard O; Skrede S; Arnell P; Oppegaard O; Itzek A; Perner A; Svensson M; Norrby-Teglund A; INFECT Study Group

Editorial comment: CLINICAL INFECTIOUS DISEASES. 2020;70(7):1461-1462

Is It Time to Reconsider the Group A Streptococcal Rheumatogenic Concept?

Norrby-Teglund A; Siemens N

Article: JOURNAL OF PROTEOME RESEARCH. 2020;19(2):688-698

Integrated Univariate, Multivariate, and Correlation-Based Network Analyses Reveal Metabolite-Specific Effects on Bacterial Growth and Biofilm Formation in Necrotizing Soft Tissue Infections.

Afzal M; Saccenti E; Madsen MB; Hansen MB; Hyldegaard O; Skrede S; Martins Dos Santos VAP; Norrby-Teglund A; Svensson M

Article: JOURNAL OF INNATE IMMUNITY. 2020;12(4):291-303

Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment.

Siemens N; Oehmcke-Hecht S; Hoßmann J; Skorka SB; Nijhuis RHT; Ruppen C; Skrede S; Rohde M; Schultz D; Lalk M; Itzek A; Pieper DH; van den Bout CJ; Claas ECJ; Kuijper EJ; Mauritz R; Sendi P; Wunderink HF; Norrby-Teglund A

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25923-25931

MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome.

Emgård J; Bergsten H; McCormick JK; Barrantes I; Skrede S; Sandberg JK; Norrby-Teglund A

Article: INTENSIVE CARE MEDICINE. 2019;45(9):1241-1251

Patient's characteristics and outcomes in necrotising soft-tissue infections: results from a Scandinavian, multicentre, prospective cohort study.

Madsen MB; Skrede S; Perner A; Arnell P; Nekludov M; Bruun T; Karlsson Y; Hansen MB; Polzik P; Hedetoft M; Rosén A; Saccenti E; Bergey F; Martins Dos Santos VAP; INFECT study group; Norrby-Teglund A; Hyldegaard O

Article: NATURE COMMUNICATIONS. 2019;10(1):3846

Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections.

Thänert R; Itzek A; Hoßmann J; Hamisch D; Madsen MB; Hyldegaard O; Skrede S; Bruun T; Norrby-Teglund A; INFECT study group; Medina E; Pieper DH

Article: JOURNAL OF INFECTIOUS DISEASES. 2019;220(4):710-719

Necrotizing Soft Tissue Infection Staphylococcus aureus but not S. pyogenes Isolates Display High Rates of Internalization and Cytotoxicity Toward Human Myoblasts.

Baude J; Bastien S; Gillet Y; Leblanc P; Itzek A; Tristan A; Bes M; Duguez S; Moreau K; Diep BA; Norrby-Teglund A; Henry T; Vandenesch F; INFECT Study Group

Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1284-1293

Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells' Type 1 Interferon Response.

Keller N; Woytschak J; Heeb LEM; Marques Maggio E; Mairpady Shambat S; Snäll J; Hyldegaard O; Boyman O; Norrby-Teglund A; Zinkernagel AS

Article: CLINICAL MICROBIOLOGY AND INFECTION. 2019;25(4):512.e7-512.e13

Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model.

Tarnutzer A; Andreoni F; Keller N; Zürcher C; Norrby-Teglund A; Schüpbach RA; Zinkernagel AS

Review: CLINICAL INFECTIOUS DISEASES. 2018;67(9):1434-1436

Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis.

Parks T; Wilson C; Curtis N; Norrby-Teglund A; Sriskandan S

Article: SCIENTIFIC REPORTS. 2018;8(1):13428

High HMGB1 levels in sputum are related to pneumococcal bacteraemia but not to disease severity in community-acquired pneumonia.

Alpkvist H; Athlin S; Mölling P; Norrby-Teglund A; Strålin K

Article: JOURNAL OF INNATE IMMUNITY. 2018;10(1):30-43

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).

Neumann A; Papareddy P; Westman J; Hyldegaard O; Snäll J; Norrby-Teglund A; Herwald H

Article: FRONTIERS IN IMMUNOLOGY. 2018;9:236

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production.

Westman J; Chakrakodi B; Snäll J; Mörgelin M; Bruun Madsen M; Hyldegaard O; Neumann A; Frick I-M; Norrby-Teglund A; Björck L; Herwald H

Article: INTENSIVE CARE MEDICINE. 2017;43(11):1585-1593

Immunoglobulin G for patients with necrotising soft tissue infection (INSTINCT): a randomised, blinded, placebo-controlled trial.

Madsen MB; Hjortrup PB; Hansen MB; Lange T; Norrby-Teglund A; Hyldegaard O; Perner A

Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(38):10000-10002

Shocking superantigens promote establishment of bacterial infection.

Siemens N; Norrby-Teglund A

Article: BMC MEDICINE. 2017;15(1):172

Macrophage activation-like syndrome: an immunological entity associated with rapid progression to death in sepsis.

Kyriazopoulou E; Leventogiannis K; Norrby-Teglund A; Dimopoulos G; Pantazi A; Orfanos SE; Rovina N; Tsangaris I; Gkavogianni T; Botsa E; Chassiou E; Kotanidou A; Kontouli C; Chaloulis P; Velissaris D; Savva A; Cullberg J-S; Akinosoglou K; Gogos C; Armaganidis A; Giamarellos-Bourboulis EJ; Hellenic Sepsis Study Group

Article: PLOS BIOLOGY. 2017;15(7):e2003167

Bacterial deception of MAIT cells in a cloud of superantigen and cytokines.

Sandberg JK; Norrby-Teglund A; Leeansyah E

Article: BLOOD. 2017;129(14):1991-2001

Neutrophils acquire the capacity for antigen presentation to memory CD4+ T cells in vitro and ex vivo.

Vono M; Lin A; Norrby-Teglund A; Koup RA; Liang F; Loré K

Article: CRITICAL CARE MEDICINE. 2017;45(4):591-599

Fever in the Emergency Department Predicts Survival of Patients With Severe Sepsis and Septic Shock Admitted to the ICU.

Sundén-Cullberg J; Rylance R; Svefors J; Norrby-Teglund A; Björk J; Inghammar M

Article: SCIENTIFIC REPORTS. 2017;7:42179

Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study.

Hansen MB; Rasmussen LS; Svensson M; Chakrakodi B; Bruun T; Madsen MB; Perner A; Garred P; Hyldegaard O; Norrby-Teglund A; INFECT study group

Article: JOURNAL OF INFECTIOUS DISEASES. 2016;214(12):1876-1883

Phosphoglycerate Kinase-A Novel Streptococcal Factor Involved in Neutrophil Activation and Degranulation.

Uhlmann J; Siemens N; Kai-Larsen Y; Fiedler T; Bergman P; Johansson L; Norrby-Teglund A

Article: SCIENTIFIC REPORTS. 2016;6:31360

A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains.

Mairpady Shambat S; Siemens N; Monk IR; Mohan DB; Mukundan S; Krishnan KC; Prabhakara S; Snäll J; Kearns A; Vandenesch F; Svensson M; Kotb M; Gopal B; Arakere G; Norrby-Teglund A

Article: JCI INSIGHT. 2016;1(10):e87882

Biofilm in group A streptococcal necrotizing soft tissue infections.

Siemens N; Chakrakodi B; Shambat SM; Morgan M; Bergsten H; Hyldegaard O; Skrede S; Arnell P; Madsen MB; Johansson L; INFECT Study Group; Juarez J; Bosnjak L; Mörgelin M; Svensson M; Norrby-Teglund A

Article: PLOS PATHOGENS. 2016;12(7):e1005732

Genetic Architecture of Group A Streptococcal Necrotizing Soft Tissue Infections in the Mouse.

Chella Krishnan K; Mukundan S; Alagarsamy J; Hur J; Nookala S; Siemens N; Svensson M; Hyldegaard O; Norrby-Teglund A; Kotb M

Article: SCIENTIFIC REPORTS. 2016;6:21288

Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release.

Snäll J; Linnér A; Uhlmann J; Siemens N; Ibold H; Janos M; Linder A; Kreikemeyer B; Herwald H; Johansson L; Norrby-Teglund A

Article: JOURNAL OF INNATE IMMUNITY. 2016;8(3):243-257

LL-37 Triggers Formation of Streptococcus pyogenes Extracellular Vesicle-Like Structures with Immune Stimulatory Properties.

Uhlmann J; Rohde M; Siemens N; Kreikemeyer B; Bergman P; Johansson L; Norrby-Teglund A

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Svåra akuta bakteriella infektioner: sjukdomsmekanismer och individanpassad medicin – Anna Norrby-Teglund grupp

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Svåra akuta bakteriella infektioner: sjukdomsmekanismer och individanpassad medicin – Anna Norrby-Teglund grupp

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