Sean Rudds forskargrupp

Mer information finns på den engelska sidan.

Gruppmedlemmar

Sean Rudd, Forskarassistent & Gruppledare
Si Min Zhang, Postdoc
Miriam Yagüe-Capilla, Postdoc
Femke Hormann, Postdoc
Christopher Dirks, Doktorand

Utvalda publikationer

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
ZhangSM, PaulinCBJ, Michel M, Marttila P, Yagüe-CapillaM, Bwanika HC, ShuH, Papagudi VenkatramR, WiitaE, Jemth AS, Almlöf I, Loseva O, Ortis F, Dirk C, Koolmeister T, Linde E, Lee S, Llona-Minguez S, Haraldsson M, Strömberg K, Homan EJ, Scobie M, Lundbäck T, Helleday T, Rudd SG
bioRxiv 2023

Targeting the DNA damage response and repair in cancer through nucleotide metabolism.
Helleday T, Rudd SG
Mol Oncol 2022 Nov;16(21):3792-3810

A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1.
Yagüe-Capilla M, Rudd SG
J Vis Exp 2021 Apr;(170):

Drug synergy scoring using minimal dose response matrices.
Mäkelä P, Zhang SM, Rudd SG
BMC Res Notes 2021 Jan;14(1):27

Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
Rudd SG, Tsesmetzis N, Sanjiv K, Paulin CB, Sandhow L, Kutzner J, Hed Myrberg I, Bunten SS, Axelsson H, Zhang SM, Rasti A, Mäkelä P, Coggins SA, Tao S, Suman S, Branca RM, Mermelekas G, Wiita E, Lee S, Walfridsson J, Schinazi RF, Kim B, Lehtiö J, Rassidakis GZ, Pokrovskaja Tamm K, Warpman-Berglund U, Heyman M, Grandér D, Lehmann S, Lundbäck T, Qian H, Henter JI, Schaller T, Helleday T, Herold N
EMBO Mol Med 2020 Mar;12(3):e10419

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism.
Tsesmetzis N, Paulin CBJ, Rudd SG, Herold N
Cancers (Basel) 2018 Jul;10(7):

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, Calderón-Montaño JM, Loseva O, Jemth AS, Bulli L, Axelsson H, Tesi B, Valerie NC, Höglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Tamm KP, Warpman-Berglund U, Walfridsson J, Lehmann S, Grandér D, Lundbäck T, Kogner P, Henter JI, Helleday T, Schaller T
Nat Med 2017 Feb;23(2):256-263