Sean Rudd

Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Artiklar

Article: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2024;:1-6
The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342
Dirks C; Bwanika HC; Jemth A-S; Zhang SM; Rudd SG
Article: ISCIENCE. 2024;27(2):108907
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang SM; Paulin CBJ; Shu H; Yagu-Capilla M; Michel M; Marttila P; Ortis F; Bwanika HC; Dirks C; Venkatram RP; Wiita E; Jemth A-S; Almlof I; Loseva O; Hormann FM; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Axelsson H; Stromberg K; Homan EJ; Scobie M; Lundback T; Helleday T; Rudd SG
Article: CELL CHEMICAL BIOLOGY. 2021;28(12):1693-1702.e6
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang SM; Rehling D; Jemth A-S; Throup A; Landazuri N; Almlof I; Gottmann M; Valerie NCK; Borhade SR; Wakchaure P; Page BDG; Desroses M; Homan EJ; Scobie M; Rudd SG; Berglund UW; Soderberg-Naucler C; Stenmark P; Helleday T
Article: CELL DEATH AND DISEASE. 2021;12(7):709
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells
Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
Article: JOURNAL OF VISUALIZED EXPERIMENTS. 2021;(170)
A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD1
Yague-Capilla M; Rudd SG
Article: BMC RESEARCH NOTES. 2021;14(1):27
Drug synergy scoring using minimal dose response matrices
Makela P; Zhang SM; Rudd SG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100568
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
Rehling D; Zhang SM; Jemth A-S; Koolmeister T; Throup A; Wallner O; Scaletti E; Moriyama T; Nishii R; Davies J; Desroses M; Rudd SG; Scobie M; Homan E; Berglund UW; Yang JJ; Helleday T; Stenmark P
Article: NATURE CHEMICAL BIOLOGY. 2020;16(10):1120-1128
Development of a chemical probe against NUDT15
Zhang SM; Desroses M; Hagenkort A; Valerie NCK; Rehling D; Carter M; Wallner O; Koolmeister T; Throup A; Jemth A-S; Almlof I; Loseva O; Lundback T; Axelsson H; Regmi S; Sarno A; Kraemer A; Pudelko L; Brautigam L; Rasti A; Gottmann M; Wiita E; Kutzner J; Schaller T; Kalderen C; Cazares-Korner A; Page BDG; Krimpenfort R; Eshtad S; Altun M; Rudd SG; Knapp S; Scobie M; Homan EJ; Berglund UW; Stenmark P; Helleday T
Article: CANCER RESEARCH. 2020;80(17):3530-3541
MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Rudd SG; Gad H; Sanjiv K; Amaral N; Hagenkort A; Groth P; Strom CE; Mortusewicz O; Berglund UW; Helleday T
Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(4):608-623
Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics
Herr P; Bostrom J; Rullman E; Rudd SG; Vesterlund M; Lehtio J; Helleday T; Maddalo G; Altun M
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: BLOOD CANCER JOURNAL. 2018;8(11):98
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens
Rassidakis GZ; Herold N; Myrberg IH; Tsesmetzis N; Rudd SG; Henter J-I; Schaller T; Ng S-B; Chng WJ; Yan B; Ng CH; Ravandi F; Andreeff M; Kantarjian HM; Medeiros LJ; Xagoraris I; Khoury JD
Article: NATURE COMMUNICATIONS. 2018;9(1):250
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
Article: EXPERIMENTAL HEMATOLOGY. 2017;52:32-39
With me or against me: Tumor suppressor and drug resistance activities of SAMHD 1
Herold N; Rudd SG; Sanjiv K; Kutzner J; Myrberg IH; Paulin CBJ; Olsen TK; Helleday T; Henter J-I; Schaller T
Article: CELL CYCLE. 2017;16(11):1029-1038
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites
Herold N; Rudd SG; Sanjiv K; Kutzner J; Bladh J; Paulin CBJ; Helleday T; Henter J-I; Schaller T
Article: MOLECULAR & CELLULAR ONCOLOGY. 2017;4(2):e1287554
SAMHD1 is a barrier to antimetabolite-based cancer therapies.
Rudd SG; Schaller T; Herold N
Article: NATURE MEDICINE. 2017;23(2):256-263
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold N; Rudd SG; Ljungblad L; Sanjiv K; Myrberg IH; Paulin CBJ; Heshmati Y; Hagenkort A; Kutzner J; Paget BDG; Calderon-Montano JM; Loseva O; Jemth A-S; Bulli L; Axelsson H; Tesi B; Valerie NCK; Hoglund A; Bladh J; Wiita E; Sundin M; Uhlin M; Rassidakis G; Heyman M; Tamm KP; Warpman-Berglund U; Walfridsson J; Lehmann S; Grander D; Lundback T; Kogner P; Henter J-I; Helleday T; Schaller T
Article: ONCOGENESIS. 2016;5(12):e275
hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia
Eshtad S; Mavajian Z; Rudd SG; Visnes T; Bostrom J; Altun M; Helleday T
Article: ANNALS OF ONCOLOGY. 2016;27(12):2275-2283
Validation and development of MTH1 inhibitors for treatment of cancer
Berglund UW; Sanjiv K; Gad H; Kalderen C; Koolmeister T; Pham T; Gokturk C; Jafari R; Maddalo G; Seashore-Ludlow B; Chernobrovkin A; Manoilov A; Pateras IS; Rasti A; Jemth A-S; Almlof I; Loseva O; Visnes T; Einarsdottir BO; Gaugaz FZ; Saleh A; Platzack B; Wallner OA; Vallin KSA; Henriksson M; Wakchaure P; Borhade S; Herr P; Kallberg Y; Baranczewski P; Homan EJ; Wiita E; Nagpal V; Meijer T; Schipper N; Rudd SG; Brautigam L; Lindqvist A; Filppula A; Lee T-C; Artursson P; Nilsson JA; Gorgoulis VG; Lehtio J; Zubarev RA; Scobie M; Helleday T
Article: NUCLEIC ACIDS RESEARCH (NAR). 2015;43(2):1056-1068
Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins
Guilliam TA; Jozwiakowski SK; Ehlinger A; Barnes RP; Rudd SG; Bailey LJ; Skehel JM; Eckert KA; Chazin WJ; Doherty AJ
Article: MOLECULAR CELL. 2013;52(4):566-573
PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication
Bianchi J; Rudd SG; Jozwiakowski SK; Bailey LJ; Soura V; Taylor E; Stevanovic I; Green AJ; Stracker TH; Lindsay HD; Doherty AJ
Article: MOLECULAR CELL. 2013;52(4):554-565
PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome
Rudd SG; Glover L; Jozwiakowski SK; Horn D; Doherty AJ
Article: BIOCHEMICAL JOURNAL. 2011;435(1):113-125
WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line
Goodfellow SJ; Rebello MR; Toska E; Zeef LAH; Rudd SG; Medler KF; Roberts SGE
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Alla övriga publikationer

Review: DISEASE MODELS & MECHANISMS. 2024;17(8):dmm050775
Understanding the interplay between dNTP metabolism and genome stability in cancer
Yague-Capilla M; Rudd SG
Preprint: BIORXIV. 2024
Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapy
Wang J; Strauss R; Bartek J; Rudd SG
Review: CANCER CHEMOTHERAPY AND PHARMACOLOGY. 2023;92(4):241-251
Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities
Rudd SG
Preprint: BIORXIV. 2023
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1viaa comprehensive screening funnel
Zhang SM; Paulin CBJ; Michel M; Marttila P; Yagüe-Capilla M; Bwanika HC; Shu H; Vekatram RP; Wiita E; Jemth A-S; Almlöf I; Loseva O; Ortis F; Dirks C; Koolmeister T; Linde E; Lee S; Llona-Minguez S; Haraldsson M; Strömberg K; Homan E; Scobie M; Lundbäck T; Helleday T; Rudd S
Review: MOLECULAR ONCOLOGY. 2022;16(21):3792-3810
Targeting the DNA damage response and repair in cancer through nucleotide metabolism
Helleday T; Rudd SG
Corrigendum: CELL DEATH AND DISEASE. 2022;13(8):672
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells (vol 12, 709, 2021)
Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
Review: PEERJ. 2022;10:e13141
The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis
Wang J; Hao S; Gu J; Rudd SG; Wang Y
Preprint: BIORXIV. 2020
Drug synergy scoring using minimal dose response matrices
Mäkelä P; Zhang SM; Rudd S
Preprint: BIORXIV. 2020
SAMHD1 promotes oncogene-induced replication stress
Zhang SM; Calderón-Montaño J; Rudd S
Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):5050
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells (vol 9, 250, 2018)
Page BDG; Valerie NCK; Wright RHG; Wallner O; Isaksson R; Carter M; Rudd SG; Loseva O; Jemth A-S; Almlof I; Font-Mateu J; Llona-Minguez S; Baranczewski P; Jeppsson F; Homan E; Almqvist H; Axelsson H; Regmi S; Gustavsson A-L; Lundback T; Scobie M; Stromberg K; Stenmark P; Beato M; Helleday T
Review: CANCERS. 2018;10(7):E240-240
Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
Tsesmetzis N; Paulin CBJ; Rudd SG; Herold N
Review: DNA REPAIR. 2016;44:193-204
Pathways controlling dNTP pools to maintain genome stability
Rudd SG; Valerie NCK; Helleday T
Review: MOLECULAR & CELLULAR ONCOLOGY. 2014;1(2):e960754
PrimPol-A new polymerase on the block.
Rudd SG; Bianchi J; Doherty AJ

Forskningsbidrag

Rudd, Sean Gareth – Data-driven refinement of antimetabolite chemotherapy in acute leukaemias
Swedish Cancer Society
1 January 2024
Overcoming drug resistance in acute leukemias with SAMHD1 inhibitors
Barncancerfonden
1 January 2022 - 31 December 2022
Rudd, Sean Gareth – Exploiting chemoresistance factor SAMHD1 to improve cancer treatment
Swedish Cancer Society
1 January 2021
Targeting SAMHD1 to enhance existing cancer therapies
Swedish Research Council
1 January 2019 - 31 December 2022

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