Radosveta Gencheva

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;208:S102-S103
The anticancer compounds auranofin, TRi-1 and TRi-2 have distinct cytotoxicity profiles with regards to thioredoxin reductase inhibition
Gencheva R; Cheng Q; Arner E
Article: REDOX BIOLOGY. 2023;62:102703
The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
Cheff DM; Huang C; Scholzen KC; Gencheva R; Ronzetti MH; Cheng Q; Hall MD; Arner ESJ
Article: TRANSLATIONAL LUNG CANCER RESEARCH. 2022;11(10):2064-2078
Plasma RNA profiling unveils transcriptional signatures associated with resistance to osimertinib in EGFR T790M positive non-small cell lung cancer patients
Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
Journal article: JOURNAL OF THORACIC ONCOLOGY. 2022;17(9):s156
P2.13-03 Plasma Profiling Unveils Transcriptional Signatures Associated with Resistance to Osimertinib in Non-Small Cell Lung Cancer
Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
Article: TRANSLATIONAL LUNG CANCER RESEARCH. 2022;11(5):722-734
Elevated expression of miR-494-3p is associated with resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer
Kazmierczak D; Eide IJZ; Gencheva R; Lai Y; Lewensohn R; Tsakonas G; Grundberg O; de Petris L; McGowan M; Brustugun OT; Ekman S; Hydbring P
Article: REDOX BIOLOGY. 2022;51:102278
Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus
Fata F; Gencheva R; Cheng Q; Lullo R; Ardini M; Silvestri I; Gabriele F; Ippoliti R; Bulman CA; Sakanari JA; Williams DL; Arner ESJ; Angelucci F
Article: REDOX BIOLOGY. 2021;48:102184
Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin
Sabatier P; Beusch CM; Gencheva R; Cheng Q; Zubarev R; Arner ESJ

Alla övriga publikationer

Thesis / dissertation: 2024
Mechanisms of action of thioredoxin reductase inhibitors in the context of cancer
Gencheva R
Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2023;201:39
THE ANTICANCER COMPOUNDS AURANOFIN, TRI-1 AND TRI-2 HAVE DISTINCT CYTOTOXICITY PROFILES WITH REGARDS TO THIOREDOXIN REDUCTASE INHIBITION
Gencheva R; Cheng Q; Arner E
Review: FREE RADICAL BIOLOGY AND MEDICINE. 2022;190:320-338
Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases
Gencheva R; Cheng Q; Arner ESJ
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2022;62:177-196
Thioredoxin Reductase Inhibition for Cancer Therapy
Gencheva R; Arner ESJ
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2022;17(9):S156
Plasma Profiling Unveils Transcriptional Signatures Associated with Resistance to Osimertinib in Non-Small Cell Lung Cancer
Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
Published conference paper: BIOCHIMICA ET BIOPHYSICA ACTA - GENERAL SUBJECTS. 2018;1862(11):2511-2517
Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase
Gencheva R; Cheng Q; Arner ESJ

Anställningar

Doktorand, Redox biokemi, Medicinsk biokemi och biofysik, Karolinska Institutet, 2020-2024

Examina och utbildning

Medicine Masterexamen, The Chemotherapeutic Potential of TRi-1: Biochemical Mechanisms of Cytotoxicity, Karolinska Institutet, 2020
Medicine Kandidatexamen, O.volvolus and B.malayi Thioredoxin Reductases As Therapeutic Targets for Lymphatic Filariasis, Karolinska Institutet, 2018

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI