Medfödda lymfoida celler (ILCs) – Jenny Mjösberg grupp

Syftet med forskningen i Jenny Mjösbergs grupp är att karaktärisera rollen för medfödda lymfoida celler, så kallade ILCs, vid inflammatorisk tarmsjukdom (IBD), kolorektalcancer, samt allergi och astma.

En del av Institutionen för medicin, Huddinge

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Publikationer
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Publikationer

Utvalda publikationer

Article: SCIENCE IMMUNOLOGY. 2022;7(70):eabj8301

CD45RA+CD62L- ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs.

Kokkinou E; Pandey RV; Mazzurana L; Gutierrez-Perez I; Tibbitt CA; Weigel W; Soini T; Carrasco A; Rao A; Nagasawa M; Bal SM; Jangard M; Friberg D; Lindforss U; Nordenvall C; Ljunggren M; Haapaniemi S; Keita ÅV; Söderholm J; Hedin C; Spits H; Bryceson YT; Mjösberg J
Article: CELL RESEARCH. 2021;31(5):554-568

Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing.

Mazzurana L; Czarnewski P; Jonsson V; Wigge L; Ringnér M; Williams TC; Ravindran A; Björklund ÅK; Säfholm J; Nilsson G; Dahlén S-E; Orre A-C; Al-Ameri M; Höög C; Hedin C; Szczegielniak S; Almer S; Mjösberg J
Article: NATURE COMMUNICATIONS. 2020;11(1):2049

Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs.

Rao A; Strauss O; Kokkinou E; Bruchard M; Tripathi KP; Schlums H; Carrasco A; Mazzurana L; Konya V; Villablanca EJ; Björkström NK; Lindforss U; Spits H; Mjösberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(6):2202-2214.e5

Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation.

Maric J; Ravindran A; Mazzurana L; Van Acker A; Rao A; Kokkinou E; Ekoff M; Thomas D; Fauland A; Nilsson G; Wheelock CE; Dahlén S-E; Ferreirós N; Geisslinger G; Friberg D; Heinemann A; Konya V; Mjösberg J
Article: JOURNAL OF CROHNS & COLITIS. 2019;13(1):67-78

Distinct Alterations in the Composition of Mucosal Innate Lymphoid Cells in Newly Diagnosed and Established Crohn's Disease and Ulcerative Colitis.

Forkel M; van Tol S; Höög C; Michaëlsson J; Almer S; Mjösberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(5):1761-1773.e6

Prostaglandin E2 suppresses human group 2 innate lymphoid cell function.

Maric J; Ravindran A; Mazzurana L; Björklund ÅK; Van Acker A; Rao A; Friberg D; Dahlén S-E; Heinemann A; Konya V; Mjösberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(1):279-292

Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells.

Konya V; Czarnewski P; Forkel M; Rao A; Kokkinou E; Villablanca EJ; Almer S; Lindforss U; Friberg D; Höög C; Bergman P; Mjösberg J
Corrigendum: NATURE IMMUNOLOGY. 2016;17(6):740

The heterogeneity of human CD127⁺ innate lymphoid cells revealed by single-cell RNA sequencing (vol 17, pg 451, 2016)

Bjorklund AK; Forkel M; Picelli S; Konya V; Theorell J; Friberg D; Sandberg R; Mjosberg J
Article: IMMUNITY. 2012;37(4):649-659

The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

Mjösberg J; Bernink J; Golebski K; Karrich JJ; Peters CP; Blom B; te Velde AA; Fokkens WJ; van Drunen CM; Spits H
Article: NATURE IMMUNOLOGY. 2011;12(11):1055-1062

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.

Mjösberg JM; Trifari S; Crellin NK; Peters CP; van Drunen CM; Piet B; Fokkens WJ; Cupedo T; Spits H

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Gruppledare

Jenny Mjösberg
Professor | Docent

Telefon +46852482917

E-postadress jenny.mjosberg@ki.se

Alla medlemmar i gruppen

John Bassett
Doktorand

E-postadress john.bassett@ki.se
Markus Bauer
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E-postadress markus.bauer.2@ki.se
Sabrina Ferreira
Postdoktor

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Jyotsana Kaushal
Postdoktor

E-postadress jyotsana.kaushal@ki.se
Madeleine Liljegren
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E-postadress madeleine.liljegren@ki.se
Anne Marchalot
Postdoktor

E-postadress anne.marchalot@ki.se
Jenny Mjösberg
Professor | Docent

Telefon +46852482917

E-postadress jenny.mjosberg@ki.se
Amanda Pereira de Freitas
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E-postadress amanda.pereira.de.freitas@ki.se
Elias Schoenwandt
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E-postadress elias.schoenwandt@ki.se
Christopher Stamper
Postdoktor

E-postadress christopher.stamper@ki.se
Jakob Theorell
Biträdande Lektor

E-postadress jakob.theorell@ki.se
Chris Tibbitt
Forskare

E-postadress chris.tibbitt@ki.se
Whitney Weigel
Laboratorieansvarig

Telefon +46852483707

E-postadress whitney.weigel@ki.se
Lorenz Wirth
Doktorand

E-postadress lorenz.wirth@ki.se
Aleksandra Zielinska
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E-postadress aleksandra.zielinska@ki.se