Medfödda lymfoida celler (ILCs) – Jenny Mjösberg grupp

Publikationer

Utvalda publikationer

• Article: PLOS PATHOGENS. 2024;20(7):e1012390

  Innate lymphoid cells are activated in HFRS, and their function can be modulated by hantavirus-induced type I interferons

  Garcia M; Garcia AC; Weigel W; Christ W; Lira-Junior R; Wirth L; Tauriainen J; Maleki K; Vanoni G; Vaheri A; Makela S; Mustonen J; Nordgren J; Smed-Sorensen A; Strandin T; Mjosberg J; Klingstrom J
• Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(4):e2350660

  Single-cell RNA sequencing of cells from fresh or frozen tissue reveals a signature of freezing marked by heightened stress and activation

  Stamper CT; Marchalot A; Tibbitt CA; Weigel W; Jangard M; Theorell J; Mjosberg J
• Article: ALLERGY. 2023;78(9):2533-2536

  Innate lymphoid cells type 2 and CD8+ T cells are perturbed in overweight and obese individuals with asthma.

  Björkander S; Maier P; Kere M; Merid SK; Wirth L; Wiegel W; Ekström S; Kull I; Bergström A; Melén E; Mjösberg J; Tibbitt CA
• Article: CELL REPORTS MEDICINE. 2023;4(5):101038

  The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis

  Kokkinou E; Soini T; Pandey RV; van Acker A; Theorell J; Czarnewski P; Kvedaraite E; Vandamme N; Lourda M; Sorini C; Weigel W; Carrasco A; Tibbitt CA; Schlums H; Lindforss U; Nordenvall C; Ljunggren M; Idestrom M; Svensson M; Henter J-I; Villablanca EJ; Bryceson YT; Rolandsdotter H; Mjosberg J
• Article: SCIENCE IMMUNOLOGY. 2022;7(70):eabj8301

  CD45RA⁺CD62L^- ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs

  Kokkinou E; Pandey RV; Mazzurana L; Gutierrez-Perez I; Tibbitt CA; Weigel W; Soini T; Carrasco A; Rao A; Nagasawa M; Bal SM; Jangard M; Friberg D; Lindforss U; Nordenvall C; Ljunggren M; Haapaniemi S; Keita AV; Soderholm J; Hedin C; Spits H; Bryceson YT; Mjosberg J
• Article: CELL RESEARCH. 2021;31(5):554-568

  Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing

  Mazzurana L; Czarnewski P; Jonsson V; Wigge L; Ringner M; Williams TC; Ravindran A; Bjorklund AK; Safholm J; Nilsson G; Dahlen S-E; Orre A-C; Al-Ameri M; Hoog C; Hedin C; Szczegielniak S; Almer S; Mjosberg J
• Article: NATURE COMMUNICATIONS. 2020;11(1):2049

  Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs

  Rao A; Strauss O; Kokkinou E; Bruchard M; Tripathi KP; Schlums H; Carrasco A; Mazzurana L; Konya V; Villablanca EJ; Bjorkstrom NK; Lindforss U; Spits H; Mjosberg J
• Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(6):2202-2214.e5

  Cytokine-induced endogenous production of prostaglandin D₂ is essential for human group 2 innate lymphoid cell activation

  Maric J; Ravindran A; Mazzurana L; Van Acker A; Rao A; Kokkinou E; Ekoff M; Thomas D; Fauland A; Nilsson G; Wheelock CE; Dahlen S-E; Ferreiros N; Geisslinger G; Friberg D; Heinemann A; Konya V; Mjosberg J
• Article: JOURNAL OF CROHNS & COLITIS. 2019;13(1):67-78

  Distinct Alterations in the Composition of Mucosal Innate Lymphoid Cells in Newly Diagnosed and Established Crohn's Disease and Ulcerative Colitis

  Forkel M; van Tol S; Hoog C; Michaelsson J; Almer S; Mjosberg J
• Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(5):1761-1773.e6

  Prostaglandin E₂ suppresses human group 2 innate lymphoid cell function

  Maric J; Ravindran A; Mazzurana L; Bjorklund AK; Van Acker A; Rao A; Friberg D; Dahlen S-E; Heinemann A; Konya V; Mjosberg J
• Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(1):279-292

  Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells

  Konya V; Czarnewski P; Forkel M; Rao A; Kokkinou E; Villablanca EJ; Almer S; Lindforss U; Friberg D; Hoeoeg C; Bergman P; Mjoesberg J
• Corrigendum: NATURE IMMUNOLOGY. 2016;17(6):740

  The heterogeneity of human CD127⁺ innate lymphoid cells revealed by single-cell RNA sequencing (vol 17, pg 451, 2016)

  Bjorklund AK; Forkel M; Picelli S; Konya V; Theorell J; Friberg D; Sandberg R; Mjosberg J
• Article: IMMUNITY. 2012;37(4):649-659

  The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.

  Mjösberg J; Bernink J; Golebski K; Karrich JJ; Peters CP; Blom B; te Velde AA; Fokkens WJ; van Drunen CM; Spits H
• Article: NATURE IMMUNOLOGY. 2011;12(11):1055-1062

  Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161.

  Mjösberg JM; Trifari S; Crellin NK; Peters CP; van Drunen CM; Piet B; Fokkens WJ; Cupedo T; Spits H

Finansiering

Forskningsbidrag

• Tissue resident lymphocytes in severe asthma and biologics treatment

  Swedish Research Council
• Mjösberg, Jenny Mari – Determining the colonic lymphocyte landscape for optimized treatment of patients with inflammatory bowel disease and metastatic colorectal cancer

  Swedish Cancer Society
• Single-cell analysis of intestinal lymphocytes reveals targets for treatment of inflammatory bowel disease

  European Research Council
• Tissue-specific regulation of human intratumoral innate and adaptive lymphocytes in colorectal cancer

  Swedish Cancer Society
• Single-cell analysis of intestinal lymphocytes to reveal targets for treatment of inflammatory bowel disease

  Swedish Research Council
• Single-cell analysis of intestinal lymphocytes to reveal targets for treatment of inflammatory bowel disease

  Swedish Research Council

Medarbetare och kontakt

Gruppledare

• 

  Jenny Mjösberg

  Professor

  Telefon +46852482917

  E-postadress jenny.mjosberg@ki.se

Alla medarbetare i gruppen

• 

  John Bassett

  E-postadress john.bassett@ki.se
• 

  Markus Bauer

  Anknuten till Forskning

  E-postadress markus.bauer.2@ki.se
• 

  Johanna Emgård

  Postdoktor

  E-postadress johanna.emgard@ki.se
• 

  Sabrina Ferreira

  Postdoktor

  E-postadress sabrina.ferreira@ki.se
• Miriam Franklin

  Postdoktor

  E-postadress miriam.franklin@ki.se
• 

  Amanda Freitas-Huhtamäki

  Anknuten till Forskning

  E-postadress amanda.pereira.de.freitas@ki.se
• 

  Jyotsana Kaushal

  Postdoktor

  E-postadress jyotsana.kaushal@ki.se
• Nicole Kleebauer

  Doktorand

  E-postadress nicole.kleebauer.2@ki.se
• 

  Madeleine Liljegren

  Anknuten till Forskning

  E-postadress madeleine.liljegren@ki.se
• 

  Anne Marchalot

  Postdoktor

  E-postadress anne.marchalot@ki.se
• 

  Jenny Mjösberg

  Professor

  Telefon +46852482917

  E-postadress jenny.mjosberg@ki.se
• Elias Schoenwandt

  Anknuten till Forskning

  E-postadress elias.schoenwandt@ki.se
• 

  Patrick Shearer

  Postdoktor

  E-postadress patrick.shearer@ki.se
• 

  Christopher Stamper

  Postdoktor

  E-postadress christopher.stamper@ki.se
• 

  Jakob Theorell

  Biträdande Lektor

  E-postadress jakob.theorell@ki.se
• 

  Chris Tibbitt

  Forskare

  E-postadress chris.tibbitt@ki.se
• 

  Lorenz Wirth

  Doktorand

  E-postadress lorenz.wirth@ki.se
• Christina Ydraiou

  Anknuten till Forskning

  E-postadress christina.ydraiou@ki.se