Jakob Theorell
Om mig
Jakob conducted his PhD studies on human immunodeficiency syndromes affecting lymphocyte cytotoxicity in the Professor Yenan Bryceson research group from 2010 to 2017, in parallel with his clinical training. After obtaining his medical license and PhD in 2017, he became as a registrar in general adult psychiatry at Psychiatry Southwest, Stockholm. In 2018, he took up a postdoctoral researcher position in the Oxford Autoimmune Neurology Group led by Professor Sarosh Irani at the University of Oxford. There, he primarily studied lymphocyte function and clonality in the context of autoimmune neurological syndromes, specifically NMDA-R, LGI1 and CASPR2 autoantibody encephalitis as well as Neuromyelitis optica.
Jakob came back to Sweden in 2020 and took up his clinical duties at Psychiatry Southwest and a postdoctoral position in Professor Fredrik Piehl's group, where he focused on immune cell phenotyping in Myasthenia gravis.In 2022, Jakob joined the Jenny Mjösberg research group at the Center for Infectious Medicine as a team leader, focusing on autoantibody-associated autoimmune encephalitis. He became a registrar in neurology at the Karolinska University Hospital in 2023. He is currently involved in building both national and Scandinavian networks for collaboration for the betterment of patient care and resarch around autoantibody-associated autoimmune encephalitis.
Artiklar
- Article: BLOOD. 2024;144(8):873-887Chiang SCC; Covill LE; Tesi B; Campbell TM; Schlums H; Nejati-Zendegani J; Mordrup K; Wood S; Theorell J; Sekine T; Al-Herz W; Akar HH; Belen FB; Chan MY; Devecioglu O; Aksu T; Ifversen M; Malinowska I; Sabel M; Unal E; Unal S; Introne WJ; Krzewski K; Gilmour KC; Ehl S; Ljunggren H-G; Nordenskjold M; Horne A; Henter J-I; Meeths M; Bryceson YT
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2024;54(4):e2350660Stamper CT; Marchalot A; Tibbitt CA; Weigel W; Jangard M; Theorell J; Mjosberg J
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(7):e2311049121Theorell J; Harrison R; Williams R; Raybould MIJ; Zhao M; Fox H; Fower A; Miller G; Wu Z; Browne E; Mgbachi V; Sun B; Mopuri R; Li Y; Waters P; Deane CM; Handel A; Makuch M; Irani SR
- Article: CELL REPORTS MEDICINE. 2023;4(5):101038Kokkinou E; Soini T; Pandey RV; van Acker A; Theorell J; Czarnewski P; Kvedaraite E; Vandamme N; Lourda M; Sorini C; Weigel W; Carrasco A; Tibbitt CA; Schlums H; Lindforss U; Nordenvall C; Ljunggren M; Idestrom M; Svensson M; Henter J-I; Villablanca EJ; Bryceson YT; Rolandsdotter H; Mjosberg J
- Article: BRAIN. 2022;145(8):2742-2754Al-Diwani A; Theorell J; Damato V; Bull J; McGlashan N; Green E; Kienzler A-K; Harrison R; Hassanali T; Campo L; Browne M; Easton A; Majd HS; Tenaka K; Iorio R; Dale RC; Harrison P; Geddes J; Quested D; Sharp D; Lee S-T; Nauen DW; Makuch M; Lennox B; Fowler D; Sheerin F; Waters P; Leite MI; Handel AE; Irani SR
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(24):e2121804119Damato V; Theorell J; Al-Diwani A; Kienzler A-K; Makuch M; Sun B; Handel A; Akdeniz D; Berretta A; Ramanathan S; Fower A; Whittam D; Gibbons E; McGlashan N; Green E; Huda S; Woodhall M; Palace J; Sheerin F; Waters P; Leite MI; Jacob A; Irani SR
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):566Theorell J; Ramberger M; Harrison R; Mgbachi V; Jacobson L; Waters P; Erhardt S; Sellgren CM; Cervenka S; Piehl F; Irani SR
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(10):e1346Leijonhufvud C; Reger R; Segerberg F; Theorell J; Schlums H; Bryceson YT; Childs RW; Carlsten M
- Article: BMC BIOINFORMATICS. 2020;21(1):336Riihimaki H; Chacholski W; Theorell J; Hillert J; Ramanujam R
- Article: BRAIN. 2020;143(6):1731-1745Ramberger M; Berretta A; Tan JMM; Sun B; Michael S; Yeo T; Theorell J; Bashford-Rogers R; Paneva S; O'Dowd V; Dedi N; Topia S; Griffin R; Ramirez-Franco J; El Far O; Baulac S; Leite MI; Sen A; Jeans A; McMillan D; Marshall D; Anthony D; Lightwood D; Waters P; Irani SR
- Article: NATURE COMMUNICATIONS. 2020;11(1):381Huhn O; Ivarsson MA; Gardner L; Hollinshead M; Stinchcombe JC; Chen P; Shreeve N; Chazara O; Farrell LE; Theorell J; Ghadially H; Parham P; Griffiths G; Horowitz A; Moffett A; Sharkey AM; Colucci F
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2019;216(6):1280-1290Hart GT; Tran TM; Theorell J; Schlums H; Arora G; Rajagopalan S; Sangala ADJ; Welsh KJ; Traore B; Pierce SK; Crompton PD; Bryceson YT; Long EO
- Journal article: FRONTIERS IN IMMUNOLOGY. 2019;10:350Theorell J; Bileviciute-Ljungar I; Tesi B; Schlums H; Johnsgaard MS; Asadi-Azarbaijani B; Strand EB; Bryceson YT
- Article: PLOS ONE. 2019;14(3):e0203247Theorell A; Bryceson YT; Theorell J
- Journal article: JOURNAL OF IMMUNOLOGY. 2018;200(Supplement_1):168.17Hart GT; Tran T; Theorell J; Arora G; Crompton P; Bryceson Y; Long EO
- Article: FRONTIERS IN IMMUNOLOGY. 2017;8:723Theorell J; Bileviciute-Ljungar I; Tesi B; Schlums H; Johnsgaard MS; Asadi-Azarbaijani B; Strand EB; Bryceson YT
- Journal article: JOURNAL OF IMMUNOLOGY. 2017;198(Supplement_1):68.19Hart GT; Theorell J; Tran T; Arora G; Crompton PD; Bryceson Y; Long EO
- Article: BLOOD. 2017;129(14):1927-1939Schlums H; Jung M; Han H; Theorell J; Bigley V; Chiang SCC; Allan DSJ; Davidson-Moncada JK; Dickinson RE; Holmes TD; Hsu AP; Townsley D; Winkler T; Wang W; Aukrust P; Nordoy I; Calvo KR; Holland SM; Collin M; Dunbar CE; Bryceson YT
- Article: BLOOD. 2017;129(14):1940-1946Corat MAF; Schlums H; Wu C; Theorell J; Espinoza DA; Sellers SE; Townsley DM; Young NS; Bryceson YT; Dunbar CE; Winkler T
- Article: DIABETES CARE. 2017;40(1):77-84Hoffstedt J; Andersson DP; Hogling DE; Theorell J; Naslund E; Thorell A; Ehrlund A; Ryden M; Arner P
- Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2016;65(9):1135-1147Sand K; Theorell J; Bruserud O; Bryceson YT; Kittang AO
- Article: NATURE IMMUNOLOGY. 2016;17(4):451-460Bjorklund AK; Forkel M; Picelli S; Konya V; Theorell J; Friberg D; Sandberg R; Mjosberg J
- Article: METHODS IN MOLECULAR BIOLOGY. 2016;1441:117-130Theorell J; Bryceson YT
- Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2015;45(7):2154-2157Hengst J; Theorell J; Deterding K; Potthoff A; Dettmer A; Ljunggren H-G; Wedemeyer H; Bjorkstrom NK
- Article: ARTHRITIS & RHEUMATOLOGY. 2015;67(4):1000-1011Hagberg N; Theorell J; Hjorton K; Spee P; Eloranta M-L; Bryceson YT; Roennblom L
- Article: IMMUNITY. 2015;42(3):443-456Schlums H; Cichocki F; Tesi B; Theorell J; Beziat V; Holmes TD; Han H; Chiang SCC; Foley B; Mattsson K; Larsson S; Schaffer M; Malmberg K-J; Ljunggren H-G; Miller JS; Bryceson YT
- Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2014;63(6):627-641Theorell J; Gustavsson A-L; Tesi B; Sigmundsson K; Ljunggren H-G; Lundbaeck T; Bryceson YT
- Journal article: BIO-PROTOCOL. 2014;4(14)Saghafian-Hedengren S; Sohlberg E; Theorell J; Carvalho-Queiroz C; Nagy N; Persson J-O; Nilsson C; Bryceson Y; Sverremark-Ekström E
- Article: JOURNAL OF VIROLOGY. 2013;87(24):13446-13455Saghafian-Hedengren S; Sohlberg E; Theorell J; Carvalho-Queiroz C; Nagy N; Persson J-O; Nilsson C; Bryceson YT; Sverremark-Ekstrom E
- Article: RHEUMATOLOGY. 2013;52(10):1818-1823Hagberg N; Theorell J; Eloranta M-L; Pascal V; Bryceson YT; Ronnblom L
- Article: JOURNAL OF IMMUNOLOGY. 2013;191(6):2989-2998Hagberg N; Theorell J; Schlums H; Eloranta M-L; Bryceson YT; Ronnblom L
- Article: BLOOD. 2013;121(8):1345-1356Chiang SCC; Theorell J; Entesarian M; Meeths M; Mastafa M; Al-Herz W; Frisk P; Gilmour KC; Ifversen M; Langenskiold C; Machaczka M; Naqvi A; Payne J; Perez-Martinez A; Sabel M; Unal E; Unal S; Winiarski J; Nordenskjold M; Ljunggren H-G; Henter J-I; Bryceson YT
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2011;366(1-2):106-118Theorell J; Schlums H; Chiang SCC; Huang TY; Tattermusch A; Wood SM; Bryceson YT
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Alla övriga publikationer
- Preprint: BIORXIV. 2024;BIORXIVFarkas AM; Youssef D; Tran MA; Balan S; Newman JH; Audenet F; Anastos H; Velazquez LG; Peros A; Ananthanarayanan A; Daza J; Gonzalez-Gugel E; Sadanala K; Theorell J; Galsky MD; Horowitz A; Sfakianos JP; Bhardwaj N
- Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2020;27:385Theorell J; Ramberger M; Harrison R; Mgbachi V; Jacobson L; Waters P; Cervenka S; Irani SR; Piehl F
- Preprint: ARXIV. 2019Riihimäki H; Chachólski W; Theorell J; Hillert J; Ramanujam R
- Preprint: BIORXIV. 2019Riihimäki H; Chachólski W; Theorell J; Hillert J; Ramanujam R
- Preprint: BIORXIV. 2018Theorell A; Bryceson YT; Theorell J
- Conference publication: JOURNAL OF IMMUNOLOGY. 2018;200(1)Hart GT; Tuan T; Theorell J; Arora G; Crompton P; Bryceson Y; Long EO
- Doctoral thesis: 2017Understanding chronic immunodeficiency disorders through assessment of cytotoxic lymphocyte functionTheorell J
- Conference publication: JOURNAL OF IMMUNOLOGY. 2017;198(1)Hart GT; Theorell J; Tuan T; Arora G; Crompton PD; Bryceson Y; Long EO
- Corrigendum: NATURE IMMUNOLOGY. 2016;17(6):740Bjorklund AK; Forkel M; Picelli S; Konya V; Theorell J; Friberg D; Sandberg R; Mjosberg J
- Corrigendum: NATURE IMMUNOLOGY. 2016;17(4)Bjorklund AK; Forkel M; Picelli S; Konya V; Theorell J; Friberg D; Sandberg R; Mjosberg J
- Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2016;395:63-94Cichocki F; Schlums H; Theorell J; Tesi B; Miller JS; Ljunggren H-G; Bryceson YT
- Conference publication: JOURNAL OF VIRAL HEPATITIS. 2015;22:68Hengst J; Theorell J; Deterding K; Potthoff A; Dettmer A; Ljunggren H-G; Wedemeyer H; Bjorkstrom NK
- Conference publication: PEDIATRIC BLOOD & CANCER. 2013;60(9):E73-E74Chiang SCC; Theorell J; Entesarian M; Meeths M; Henter J-I; Bryceson YT
- Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:183.15Saghafian-Hedengren S; Sohlberg E; Theorell J; Queiroz-Carvalho C; Nagy N; Nilsson C; Bryceson Y; Sverremark-Ekstrom E
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2012;64(10):S368-S369Hagberg N; Theorell J; Alm GV; Eloranta M-L; Bryceson Y; Ronnblom L
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A3Hagberg N; Theorell J; Alm GV; Eloranta M-L; Bryceson Y; Ronnblom L
- Review: JOURNAL OF INNATE IMMUNITY. 2011;3(3):216-226Bryceson YT; Chiang SCC; Darmanin S; Fauriat C; Schlums H; Theorell J; Wood SM
Forskningsbidrag
- Swedish Research Council1 December 2023 - 30 November 2027Autoimmune encephalitides (AEs) are a group of recently identified disorders that can present with symptoms such as psychosis, epilepsy ataxia and/or dementia. AEs are often reversible upon correct treatment, distinguishing them from the syndromes that they mimick. With this application, I intend to address a set of outstanding epidemiological and immunopathological questions about AE. The specific aims are to determine 1) the prevalence of AE among patients with catatonia cared for within the legal framework of “Lagen om Psykiatrisk Tvångsvård” 2) the role of the n-methyl-d-aspartate receptor (NMDA-R) in modulating immune responses and its role in encephalitis development. 3) clonal relationships of infiltrating immune cells in the human brain, cerebrospinal fluid (CSF), lymph nodes and blood, to elucidate the steady-state brain immunology underpinning all AE immunopathology 4) antigen-specific CD8 T cell function in the context of glutamate decarboxylase 65 (GAD65)-autoantibody associated neurological syndromes.As a clinician-scientist with extensive clinical networks in Sweden and abroad and a profound biological, experimental and bioinformatical track-record in the field, I am uniquely positioned to address these translational questions. My long-term goal is to identify and treat all patients suffering from AE in Sweden.
Anställningar
- Biträdande Lektor, Medicin, Huddinge, Karolinska Institutet, 2022-2028
Examina och utbildning
- Medicine Doktorsexamen, Institutionen för medicin, Huddinge, Karolinska Institutet, 2017
- Läkarexamen, Karolinska Institutet, 2014