Jakob Theorell

Jakob Theorell

Biträdande Lektor
E-postadress: jakob.theorell@ki.se
Besöksadress: Alfred Nobels allé 8, plan 7, 14152 HUDDINGE
Postadress: H7 Medicin, Huddinge, H7 CIM Mjösberg Theorell, 171 77 Stockholm

Om mig

  • Jakob conducted his PhD studies on human immunodeficiency syndromes affecting lymphocyte cytotoxicity in the Professor Yenan Bryceson research group from 2010 to 2017, in parallel with his clinical training. After obtaining his medical license and PhD in 2017, he became as a registrar in general adult psychiatry at Psychiatry Southwest, Stockholm. In 2018, he took up a postdoctoral researcher position in the Oxford Autoimmune Neurology Group led by Professor Sarosh Irani at the University of Oxford. There, he primarily studied lymphocyte function and clonality in the context of autoimmune neurological syndromes, specifically NMDA-R, LGI1 and CASPR2 autoantibody encephalitis as well as Neuromyelitis optica.

    Jakob came back to Sweden in 2020 and took up his clinical duties at Psychiatry Southwest and a postdoctoral position in Professor Fredrik Piehl's group, where he focused on immune cell phenotyping in Myasthenia gravis.

    In 2022, Jakob joined the Jenny Mjösberg research group at the Center for Infectious Medicine as a team leader, focusing on autoantibody-associated autoimmune encephalitis. He became a registrar in neurology at the Karolinska University Hospital in 2023. He is currently involved in building both national and Scandinavian networks for collaboration for the betterment of patient care and resarch around autoantibody-associated autoimmune encephalitis. 

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 December 2023 - 30 November 2027
    Autoimmune encephalitides (AEs) are a group of recently identified disorders that can present with symptoms such as psychosis, epilepsy ataxia and/or dementia. AEs are often reversible upon correct treatment, distinguishing them from the syndromes that they mimick. With this application, I intend to address a set of outstanding epidemiological and immunopathological questions about AE. The specific aims are to determine 1) the prevalence of AE among patients with catatonia cared for within the legal framework of “Lagen om Psykiatrisk Tvångsvård” 2) the role of the n-methyl-d-aspartate receptor (NMDA-R) in modulating immune responses and its role in encephalitis development. 3) clonal relationships of infiltrating immune cells in the human brain, cerebrospinal fluid (CSF), lymph nodes and blood, to elucidate the steady-state brain immunology underpinning all AE immunopathology 4) antigen-specific CD8 T cell function in the context of glutamate decarboxylase 65 (GAD65)-autoantibody associated neurological syndromes.As a clinician-scientist with extensive clinical networks in Sweden and abroad and a profound biological, experimental and bioinformatical track-record in the field, I am uniquely positioned to address these translational questions. My long-term goal is to identify and treat all patients suffering from AE in Sweden.

Anställningar

  • Biträdande Lektor, Medicin, Huddinge, Karolinska Institutet, 2022-2028

Examina och utbildning

  • Medicine Doktorsexamen, Institutionen för medicin, Huddinge, Karolinska Institutet, 2017
  • Läkarexamen, Karolinska Institutet, 2014

Nyheter från KI

Kalenderhändelser från KI